               SEQUENCE LISTING

<110> Academisch Medisch Centrum

<120> BMP4 specific antibodies

<130> INV-00396

<160> 18

<170> BiSSAP 1.2

<210> 1
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> BMP4

<400> 1
Lys His His Ser Gln Arg Ala Arg Lys Lys Asn Lys Asn Cys Arg Arg 
1               5                   10                  15      
His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          
Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr Cys His Gly Asp Cys Pro 
        35                  40                  45              
Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  
Thr Leu Val Asn Ser Val Asn Ser Ser Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  
Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Tyr Asp 
                85                  90                  95      
Lys Val Val Leu Lys Asn Tyr Gln Glu Met Val Val Glu Gly Cys Gly 
            100                 105                 110         
Cys Arg 
        

<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1

<400> 2
Gly Arg Thr Phe Ser Thr Tyr Ala 
1               5               

<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2

<400> 3
Ser Lys Gly Gly Gly Ile Thr Tyr 
1               5               

<210> 4
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3

<400> 4
Asp Pro Val Ser Ser Val Ala Lys Ser Pro Val Ala Tyr Pro 
1               5                   10                  

<210> 5
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of C8

<400> 5
Gly Arg Thr Phe Arg Ile Asn Asp 
1               5               

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of C8

<400> 6
Thr Ser Gly Gly Asn Thr Asn 
1               5           

<210> 7
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of C8

<400> 7
Asp Gly Leu Arg Phe Asp Ser Thr Arg Tyr Arg Pro Phe Asp 
1               5                   10                  

<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR1 of E7

<400> 8
Gly Ser Ile Arg Gly Phe Val Ala 
1               5               

<210> 9
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR2 of E7

<400> 9
Thr Asn Gly Gly Thr Leu 
1               5       

<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> CDR3 of E7

<400> 10
Arg Gln Ile Gly Ala Ser Gly Tyr Asp 
1               5                   

<210> 11
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> C4

<400> 11
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Thr Tyr 
            20                  25                  30          
Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              
Ala Ala Ile Ser Lys Gly Gly Gly Ile Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Lys Glu Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Ala Asp Pro Val Ser Ser Val Ala Lys Ser Pro Val Ala Tyr Pro 
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 

<210> 12
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> C8

<400> 12
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Ile Asn 
            20                  25                  30          
Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Ser Arg Asp Met Val 
        35                  40                  45              
Ala Arg Ile Thr Ser Gly Gly Asn Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  
Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      
Ala Asp Gly Leu Arg Phe Asp Ser Thr Arg Tyr Arg Pro Phe Asp Ser 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 13
<400> 13
000

<210> 14
<211> 117
<212> PRT
<213> Artificial Sequence

<220> 
<223> E7

<400> 14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Arg Gly Phe Val 
            20                  25                  30          
Ala Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              
Ala Thr Val Thr Asn Gly Gly Thr Leu Tyr Gly Asp Ser Val Lys Gly 
    50                  55                  60                  
Arg Phe Thr Gly Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Leu 
                85                  90                  95      
Arg Gln Ile Gly Ala Ser Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Gln 
            100                 105                 110         
Val Thr Val Ser Ser 
        115         

<210> 15
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> BMP2

<400> 15
Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      
His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          
Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              
Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  
Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  
Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      
Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         
Cys Arg 
        

<210> 16
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> BMP5

<400> 16
Ser Val Gly Asp Tyr Asn Thr Ser Glu Gln Lys Gln Ala Cys Lys Lys 
1               5                   10                  15      
His Glu Leu Tyr Val Ser Phe Arg Asp Leu Gly Trp Gln Asp Trp Ile 
            20                  25                  30          
Ile Ala Pro Glu Gly Tyr Ala Ala Phe Tyr Cys Asp Gly Glu Cys Ser 
        35                  40                  45              
Phe Pro Leu Asn Ala His Met Asn Ala Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  
Thr Leu Val His Leu Met Phe Pro Asp His Val Pro Lys Pro Cys Cys 
65                  70                  75                  80  
Ala Pro Thr Lys Leu Asn Ala Ile Ser Val Leu Tyr Phe Asp Asp Ser 
                85                  90                  95      
Ser Asn Val Ile Leu Lys Lys Tyr Arg Asn Met Val Val Arg Ser Cys 
            100                 105                 110         
Gly Cys His 
        115 

<210> 17
<211> 139
<212> PRT
<213> Artificial Sequence

<220> 
<223> BMP6

<400> 17
Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser Arg Asn Arg Ser Thr Gln 
1               5                   10                  15      
Ser Gln Asp Val Ala Arg Val Ser Ser Ala Ser Asp Tyr Asn Ser Ser 
            20                  25                  30          
Glu Leu Lys Thr Ala Cys Arg Lys His Glu Leu Tyr Val Ser Phe Gln 
        35                  40                  45              
Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Lys Gly Tyr Ala Ala 
    50                  55                  60                  
Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn 
65                  70                  75                  80  
Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Leu Met Asn Pro 
                85                  90                  95      
Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile 
            100                 105                 110         
Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             
Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 

<210> 18
<211> 139
<212> PRT
<213> Artificial Sequence

<220> 
<223> BMP7

<400> 18
Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      
Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          
Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              
Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  
Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  
Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      
Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         
Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             
Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 

