                         SEQUENCE LISTING

<110>  Isis Pharmaceuticals, Inc.
 
<120>  ANTISENSE COMPOUNDS AND USES THEREOF

<130>  CORE0128WO

<150>  62/052,831
<151>  2014-09-19

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2512
<212>  DNA
<213>  Mus musculus

<400>  1
ggggcgggct gcccgggcca tggcgcataa agcctctggc cacctgcagg gctactgctg       60

ctccggccac cgccaggcac acaccttgct gctgagggag tctcggcttc tgtcatctct      120

gtggcctccg tcacctctgt ctccgtctcc ttcaggtcct gagccccgag agccccttcc      180

gcgcacgcgg acatgggcgg cagctccagg gcgcgctggg tggccttggg gttgggcgcc      240

ctggggctgc tgtttgctgc gctcggcgtt gtcatgatcc tcatggtgcc ctccctcatc      300

aagcagcagg tgctcaagaa tgtccgcata gacccgagca gcctgtcctt cgggatgtgg      360

aaggagatcc ccgtcccttt ctacttgtct gtctacttct tcgaagtggt caacccaaac      420

gaggtcctca acggccagaa gccagtagtc cgggagcgtg gaccctatgt ctacagggag      480

ttcagacaaa aggtcaacat caccttcaat gacaacgaca ccgtgtcctt cgtggagaac      540

cgcagcctcc atttccagcc tgacaagtcg catggctcag agagtgacta cattgtactg      600

cctaacatct tggtcctggg gggctcgata ttgatggaga gcaagcctgt gagcctgaag      660

ctgatgatga ccttggcgct ggtcaccatg ggccagcgtg cttttatgaa ccgcacagtt      720

ggtgagatcc tgtggggcta tgacgatccc ttcgtgcatt ttctcaacac gtacctccca      780

gacatgcttc ccataaaggg caaatttggc ctgtttgttg ggatgaacaa ctcgaattct      840

ggggtcttca ctgtcttcac gggcgtccag aatttcagca ggatccatct ggtggacaaa      900

tggaacggac tcagcaagat cgattattgg cattcagagc agtgtaacat gatcaatggg      960

acttccgggc agatgtgggc acccttcatg acacccgaat cctcgctgga attcttcagc     1020

ccggaggcat gcaggtccat gaagctgacc tacaacgaat caagggtgtt tgaaggcatt     1080

cccacgtatc gcttcacggc ccccgatact ctgtttgcca acgggtccgt ctacccaccc     1140

aacgaaggct tctgcccatg ccgagagtct ggcattcaga atgtcagcac ctgcaggttt     1200

ggtgcgcctc tgtttctctc ccacccccac ttttacaacg ccgaccctgt gttgtcagaa     1260

gctgttcttg gtctgaaccc taacccaaag gagcattcct tgttcctaga catccatccg     1320

gtcactggga tccccatgaa ctgttctgtg aagatgcagc tgagcctcta catcaaatct     1380

gtcaagggca tcgggcaaac agggaagatc gagccagtag ttctgccgtt gctgtggttc     1440

gaacagagcg gagcaatggg tggcaagccc ctgagcacgt tctacacgca gctggtgctg     1500

atgccccagg ttcttcacta cgcgcagtat gtgctgctgg ggcttggagg cctcctgttg     1560

ctggtgccca tcatctgcca actgcgcagc caggagaaat gctttttgtt ttggagtggt     1620

agtaaaaagg gctcccagga taaggaggcc attcaggcct actctgagtc cctgatgtca     1680

ccagctgcca agggcacggt gctgcaagaa gccaagctat agggtcctga agacactata     1740

agccccccaa acctgatagc ttggtcagac cagccaccca gtccctacac cccgcttctt     1800

gaggactctc tcagcggaca gcccaccagt gccatggcct gagcccccag atgtcacacc     1860

tgtccgcacg cacggcacat ggatgcccac gcatgtgcaa aaacaactca gggaccaggg     1920

acagacctgc tgccaagtga gcctgatggg ccacaggtgt gctcttctaa atggcctgtg     1980

agccaggctg tgggaactct agctgctgtc agcccctcct gtaggagctg gccctgccca     2040

ggctcctgac ttccctcagg aagtctttct gtctttctcc atcagtctga aagccttagt     2100

tcccacagag gacggatctg tcactcctag gggctgggca tatgtcggcc tcttgtgcca     2160

aggccaggca agcagctcca ggtcctgacc agtttgcaca cacactctgg agctgtatct     2220

ggcgcttttt ctatcgtctc tgctatgtca ctgaattaac cactgtacgt ggcagaggtg     2280

gcaggcccct cagggtcctt atttttcagg catggggtca aagctagagg tatgggccgt     2340

ctacaccccc ccgccccccg gcatctagtg tacctcacca gagggtattc ggaggcccag     2400

catcctgcaa ccgacccctt ttttctactg gaagagaaat tttatcatct tttgaaagga     2460

agtcatgact gaagcaataa accttttcac tgattcaaaa aaaaaaaaaa aa             2512


<210>  2
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
gcttcagtca tgacttcctt                                                   20


<210>  3
<211>  6982
<212>  DNA
<213>  Mus musculus

<400>  3
aggcattcag gcagcgagag cagagcagcg tagagcagca cagctgagct cgtgaggcag       60

gagactcagc ccgaggaaat cgcagataag tttttaatta aaaagattga gcagtaaaaa      120

gaattagaac tctaaactta agctaataga gtagcttatc gaaatattac ttagtcttaa      180

taatctaaga agatcttaag agataacatg aaggcttatt taaacagttt gaaaaaggaa      240

atgaggagaa aagtatttgt actgtataat ggaggctgac cagagcagtt taggagattg      300

taaagggagg ttttgtgaag ttctaaaagg ttctagtttg aaggtcggcc ttgtagatta      360

aaacgaaggt tacctaaata gaatctaagt ggcatttaaa acagtaaagt tgtagagaat      420

agtttgaaaa tgaggtgtag ttttaaaaga ttgagaaaag taggttaagt tgacggccgt      480

tataaaaatc cttcgactgg cgcatgtacg tttgaaggca tgagttggaa acagggaaga      540

tggaagtgtt aggctagccg ggcgatggtg gcgcacgcct ttaatcctag cacttgggag      600

gcagaggcag gcggatttct gagttcgagg ccagcctggt ctacagagtg agttccagga      660

cagccagggc tacacagaga aaccctgtct tgaaaaaaca aaaaggttag gctagtattt      720

ggagaaagaa gattagaaaa tggaagtgaa agacgaagaa gacatacagg aaggtgaaga      780

aaaagctgtt agagaagata ggaaaataga agacaaagca tctttagaag acagaaaagg      840

tacttaaagg cacaggtagt aggaagccga agaatagaag atagaaagaa gcaagataga      900

aaaacaaaat ggaagttaag acaactttgg atgccagcat tcaagatagg caaagaagat      960

aagattgagg ccaaaaggtt ggataagata taaagtcaga aggaaattat ctttaaagcc     1020

ataagttcaa atttctgatg gagcgagcag tttagaagag tctttagaca gccacataca     1080

agattgaagc tagcaatcaa agctactagg actgaagtaa aaagttaagg cagaatgcct     1140

ttgaagagtt agaagaatat taaaagcctt aacttgtagc ttaattttgc ttgatgacaa     1200

aaggactttt gataacagtt tcaagattgt cagcattttg cattggactt gagctgaggt     1260

gcttttaaaa tcctaacgac tagcattggc agctgaccca ggtctacaca gaagtgcatt     1320

cagtgaacta ggaagacagg agcggcagac aggagtcccg aagccagttt ggtgaagcta     1380

ggaaggactg aggagccagc agcagcagtg catggtgaag atagcccagg aaagagtgcg     1440

gttcggtgga ggaagctagg aagaaggagc catacggatg tggtggtgaa gctgggaaag     1500

ggttccagga tggtggagcg agagcgagtt ggtgatgaag ctagctggcg gcttggcttg     1560

tcaactgcgc ggaggaggcg agcaggcatt gtggagagga tagatagcgg ctcctagacc     1620

agcatgccag tgtgcaagaa aggctgcagg gagagcatgc ggtgcggtaa cattccttga     1680

ggtcggcaac atggtggtgg ttttctgtaa cttggatggt aacttgttta ctttgtctta     1740

atagttatgg gggagttgta ggcttctgtg taaagagata tatctggggc tgtatgtagg     1800

cctttgcggg tgttgtaggt ttttcttttt cagggttatg tcctcttgca tcttgtcaga     1860

agcttttgag ggctgactgc caaggcccag aaagaagaat ggtagatggc aagttgtctt     1920

taaccgctca gaggggaatg aatggtagag ccagcacaac ctcccagttt tgtaagacgt     1980

tgtagtttga acagatgacc taccacaagc ctcactcctg tgtaggggag gtaattgggc     2040

aaagtgcttt tgggggaatg ggggcaaaat atattttgag ttcttttccc cttaggtctg     2100

tctagaatcc taaaggcaga tgactcaagg gaaccagaaa aaaggaaatc cactctcagg     2160

ataagcagag ctcgccaggt ttacagtttg taggaagtag aggatggatg ctagctttca     2220

cactgagtgt ggaggagctg gccatggcgg aattgctggt agtttactct ttccccctcc     2280

cttaatgaga tttgtaaaat cctaaacact tttacttgaa atatttggga gtggtcttaa     2340

cagggaggag tgggtggggg aaacgttttt tttctaagat tttccacaga tgctatagtt     2400

gtgttgacac actgggttag agaaggcgtg tactgctatg ctgttggcac gacaccttca     2460

gggactggag ctgccttttg tccttggaag agttttccca gttgccgctg aagtcagcac     2520

agtgcggctt tggttcacag tcacctcagg agaacctcag gagcttggct aggccagagg     2580

ttgaagttaa gttttacagc accgtgattt aaaatatttc attaaagggg aggggtaaaa     2640

cttagttggc tgtggccttg tgtttgggtg ggtgggggtg ttaggtaatt gtttagttta     2700

tgatttcaga taatcatacc agagaactta aatatttgga aaaacaggaa atctcagctt     2760

tcaagttggc aagtaactcc caatccagtt tttgcttctt ttttcctttt tctttttttg     2820

aggcgggcag ctaaggaagg ttggttcctc tgccggtccc tcgaaagcgt agggcttggg     2880

ggttggtctg gtccactggg atgatgtgat gctacagtgg ggactcttct gaagctgttg     2940

gatgaatata gattgtagtg tgtggttctc ttttgaaatt tttttcaggt gacttaatgt     3000

atcttaataa ctactatagg aacaaaggaa gtggctttaa tgaccctgaa ggaatttctt     3060

ctggtgatag cttttatatt atcaagtaag agatactatc tcagttttgt ataagcaagt     3120

ctttttccta gtgtaggaga aatgattttc cttgtgacta aacaagatgt aaaggtatgc     3180

tttttttctt cttgtgcatt gtatacttgt gtttatttgt aacttataat ttaagaatta     3240

tgataattca gcctgaatgt cttttagagg gtgggctttt gttgatgagg gaggggaaac     3300

cttttttttt ctgtagacct ttttcagata acaccatctg agtcataacc agcctggcag     3360

tgtgatgacg tagatgcaga gggagcagct ccttggtgaa tgagtgataa gtaaaggcag     3420

aaaaaataat gtcatgtctc catggggaat gagcatgagc cagagattgt tcctactgat     3480

gaaaagctgc atatgcaaaa atttaagcaa atgaaagcaa ccagtataaa gttatggcaa     3540

tacctttaaa agttatggct tatctaccaa gctttatcca caaaagtaaa gaattgatga     3600

aaaacagtga agatcaaatg ttcatctcaa aactgctttt acaaaagcag aatagaaatg     3660

aagtgaaaat gctgcattaa gcctggagta aaaagaagct gagcttgttg agatgagtgg     3720

gatcgagcgg ctgcgaggcg gtgcagtgtg ccaatgtttc gtttgcctca gacaggtttc     3780

tcttcataag cagaagagtt gcttcattcc atctcggagc aggaaacagc agactgctgt     3840

tgacagataa gtgtaacttg gatctgcagt attgcatgtt agggatagat aagtgccttt     3900

tttctctttt tccaaaaaga cctgtagagc tgttgaatgt ttgcagctgg cccctcttag     3960

gcagttcaga attttgagta gttttcccat ccagcctctt aaaaattcct aagccttgca     4020

ccgatgggct ttcatgatgg gatagctaat aggcttttgc atcgtaaact tcaacacaaa     4080

agcctacatg attaatgcct actttaatta cattgcttac aagattaagg aatctttatc     4140

ttgaagaccc catgaaaggg atcattatgt gctgaaaatt agatgttcat attgctaaaa     4200

tttaaatgtg ctccaatgta cttgtgctta aaatcattaa attatacaaa ttaataaaat     4260

acttcactag agaatgtatg tatttagaag gctgtctcct tatttaaata aagtcttgtt     4320

tgttgtctgt agttagtgtg ggcaattttg gggggatgtt cttctctaat cttttcagaa     4380

acttgacttc gaacacttaa gtggaccaga tcaggatttg agccagaaga ccgaaattaa     4440

ctttaaggca ggaaagacaa attttattct ccatgcagtg atgagcattt aataattgca     4500

ggcctggcat agaggccgtc taactaagga ctaagtacct taggcaggtg ggagatgatg     4560

gtcagagtaa aaggtaacta catattttgt ttccagaaag tcaggggtct aatttgacca     4620

tggctaaaca tctagggtaa gacacttttc ccccacattt ccaaatatgc atgttgagtt     4680

taaatgctta cgatcatctc atccacttta gccttttgtc acctcacttg agccacgagt     4740

ggggtcaggc atgtgggttt aaagagtttt cctttgcaga gcctcatttc atccttcatg     4800

gagctgctca ggactttgca tataagcgct tgcctctgtc ttctgttctg ctagtgagtg     4860

tgtgatgtga gaccttgcag tgagtttgtt tttcctggaa tgtggaggga gggggggatg     4920

gggcttactt gttctagctt tttttttaca gaccacacag aatgcaggtg tcttgacttc     4980

aggtcatgtc tgttctttgg caagtaatat gtgcagtact gttccaatct gctgctatta     5040

gaatgcattg tgacgcgact ggagtatgat taaagaaagt tgtgtttccc caagtgtttg     5100

gagtagtggt tgttggagga aaagccatga gtaacaggct gagtgttgag gaaatggctc     5160

tctgcagctt taagtaaccc gtgtttgtga ttggagccga gtccctttgc tgtgctgcct     5220

taggtaaatg tttttgttca tttctggtga ggggggttgg gagcactgaa gcctttagtc     5280

tcttccagat tcaacttaaa atctgacaag aaataaatca gacaagcaac attcttgaag     5340

aaattttaac tggcaagtgg aaatgttttg aacagttccg tggtctttag tgcattatct     5400

ttgtgtaggt gttctctctc ccctcccttg gtcttaattc ttacatgcag gaacattgac     5460

aacagcagac atctatctat tcaaggggcc agagaatcca gacccagtaa ggaaaaatag     5520

cccatttact ttaaatcgat aagtgaagca gacatgccat tttcagtgtg gggattggga     5580

agccctagtt ctttcagatg tacttcagac tgtagaagga gcttccagtt gaattgaaat     5640

tcaccagtgg acaaaatgag gacaacaggt gaacgagcct tttcttgttt aagattagct     5700

actggtaatc tagtgttgaa tcctctccag cttcatgctg gagcagctag catgtgatgt     5760

aatgttggcc ttggggtgga ggggtgaggt gggcgctaag ccttttttta agatttttca     5820

ggtacccctc actaaaggca ctgaaggctt aatgtaggac agcggagcct tcctgtgtgg     5880

caagaatcaa gcaagcagta ttgtatcgag accaaagtgg tatcatggtc ggttttgatt     5940

agcagtgggg actaccctac cgtaacacct tgttggaatt gaagcatcca aagaaaatac     6000

ttgagaggcc ctgggcttgt tttaacatct ggaaaaaagg ctgtttttat agcagcggtt     6060

accagcccaa acctcaagtt gtgcttgcag gggagggaaa agggggaaag cgggcaacca     6120

gtttccccag cttttccaga atcctgttac aaggtctccc cacaagtgat ttctctgcca     6180

catcgccacc atgggccttt ggcctaatca cagacccttc acccctcacc ttgatgcagc     6240

cagtagctgg atccttgagg tcacgttgca tatcggtttc aaggtaacca tggtgccaag     6300

gtcctgtggg ttgcaccaga aaaggccatc aattttcccc ttgcctgtaa tttaacatta     6360

aaaccatagc taagatgttt tatacatagc acctatgcag agtaaacaaa ccagtatggg     6420

tatagtatgt ttgataccag tgctgggtgg gaatgtagga agtcggatga aaagcaagcc     6480

tttgtaggaa gttgttgggg tgggattgca aaaattctct gctaagactt tttcaggtgg     6540

acataacaga cttggccaag ctagcatctt agtggaagca gattcgtcag tagggttgta     6600

aaggtttttc ttttcctgag aaaacaacct tttgttttct caggttttgc tttttggcct     6660

ttccctagct ttaaaaaaaa aaaagcaaaa gacgctggtg gctggcactc ctggtttcca     6720

ggacggggtt caagtccctg cggtgtcttt gcttgactct tatatcatga ggccattaca     6780

tttttcttgg agggttctaa aggctctggg tatggtagct gatatcactg gaacactccc     6840

cagcctcagt gttgaactct tgataattaa ctgcattgtc tttcaggtta tgcccaattc     6900

gtcttattac ctctgagtcg acacacctcc tactatttat tgaatacttt gattttatga     6960

aataaaaact aaatatctct ca                                              6982


<210>  4
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  4
ggcttaatgc agcatt                                                       16


