                         SEQUENCE LISTING

<110>  Heczey, Andras Attila
       Gottschalk, Stephen M.G.
       Metelitsa, Leonid S.
       Dotti, Gianpietro
 
<120>  GLYPICAN-3 CHIMERIC ANTIGEN RECEPTORS

<130>  BAYM.P0150WO-11509126

<140>  UNKNOWN
<141>  2015-09-25

<150>  62/055,979
<151>  2014-09-26

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Lys Trp Ile Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
        195                 200                 205             


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 


Phe Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys 
            260     


<210>  2
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Thr Gly Gly Ala Thr Thr Gly Gly Ala Thr Thr Thr Gly Gly Cys 
1               5                   10                  15      


Gly Cys Ala Thr Thr Cys Thr Gly Thr Thr Thr Cys Thr Gly Gly Thr 
            20                  25                  30          


Gly Gly Gly Ala Gly Cys Cys Gly Cys Ala Ala Cys Cys Gly Gly Ala 
        35                  40                  45              


Gly Cys Ala Cys Ala Thr Ala Gly Thr Cys Ala Gly Gly Thr Cys Cys 
    50                  55                  60                  


Ala Gly Cys Thr Gly Cys Ala Gly Cys Ala Gly Thr Cys Ala Gly Gly 
65                  70                  75                  80  


Ala Gly Cys Cys Gly Ala Ala Cys Thr Gly Gly Thr Gly Cys Gly Gly 
                85                  90                  95      


Cys Cys Cys Gly Gly Cys Gly Cys Ala Ala Gly Thr Gly Thr Cys Ala 
            100                 105                 110         


Ala Ala Cys Thr Gly Thr Cys Ala Thr Gly Cys Ala Ala Gly Gly Cys 
        115                 120                 125             


Cys Ala Gly Cys Gly Gly Gly Thr Ala Thr Ala Cys Cys Thr Thr Cys 
    130                 135                 140                 


Ala Cys Ala Gly Ala Cys Thr Ala Cys Gly Ala Gly Ala Thr Gly Cys 
145                 150                 155                 160 


Ala Cys Thr Gly Gly Gly Thr Gly Ala Ala Ala Cys Ala Gly Ala Cys 
                165                 170                 175     


Cys Cys Cys Thr Gly Thr Gly Cys Ala Cys Gly Gly Cys Cys Thr Gly 
            180                 185                 190         


Ala Ala Gly Thr Gly Gly Ala Thr Cys Gly Gly Cys Gly Cys Thr Cys 
        195                 200                 205             


Thr Gly Gly Ala Cys Cys Cys Ala Ala Ala Ala Ala Cys Cys Gly Gly 
    210                 215                 220                 


Gly Gly Ala Thr Ala Cys Ala Gly Cys Ala Thr Ala Thr Thr Cys Cys 
225                 230                 235                 240 


Cys Ala Gly Ala Ala Gly Thr Thr Thr Ala Ala Ala Gly Gly Ala Ala 
                245                 250                 255     


Ala Gly Gly Cys Cys Ala Cys Thr Cys Thr Gly Ala Cys Cys Gly Cys 
            260                 265                 270         


Thr Gly Ala Cys Ala Ala Gly Ala Gly Cys Thr Cys Cys Thr Cys Thr 
        275                 280                 285             


Ala Cys Thr Gly Cys Cys Thr Ala Cys Ala Thr Gly Gly Ala Gly Cys 
    290                 295                 300                 


Thr Gly Ala Gly Gly Ala Gly Cys Cys Thr Gly Ala Cys Ala Thr Cys 
305                 310                 315                 320 


Cys Gly Ala Ala Gly Ala Thr Ala Gly Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Thr Ala Cys Thr Ala Thr Thr Gly Cys Ala Cys Cys Cys Gly Cys Thr 
            340                 345                 350         


Thr Cys Thr Ala Cys Thr Cys Cys Thr Ala Thr Ala Cys Ala Thr Ala 
        355                 360                 365             


Cys Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Gly Ala Cys Thr 
    370                 375                 380                 


Cys Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr Cys Thr Cys Thr Gly 
385                 390                 395                 400 


Cys Ala Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Cys Thr Cys 
                405                 410                 415     


Thr Gly Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Gly Ala Gly Thr 
            420                 425                 430         


Gly Gly Ala Gly Gly Cys Gly Gly Gly Gly Gly Ala Ala Gly Cys Gly 
        435                 440                 445             


Ala Cys Gly Thr Gly Gly Thr Cys Ala Thr Gly Ala Cys Ala Cys Ala 
    450                 455                 460                 


Gly Ala Cys Thr Cys Cys Ala Cys Thr Gly Thr Cys Cys Cys Thr Gly 
465                 470                 475                 480 


Cys Cys Cys Gly Thr Gly Ala Gly Cys Cys Thr Gly Gly Gly Cys Gly 
                485                 490                 495     


Ala Thr Cys Ala Gly Gly Cys Thr Ala Gly Cys Ala Thr Thr Thr Cys 
            500                 505                 510         


Cys Thr Gly Thr Cys Gly Ala Ala Gly Thr Thr Cys Ala Cys Ala Gly 
        515                 520                 525             


Ala Gly Thr Cys Thr Gly Gly Thr Gly Cys Ala Cys Thr Cys Ala Ala 
    530                 535                 540                 


Ala Cys Gly Gly Ala Ala Ala Thr Ala Cys Cys Thr Ala Thr Cys Thr 
545                 550                 555                 560 


Gly Cys Ala Thr Thr Gly Gly Thr Ala Cys Cys Thr Gly Cys Ala Gly 
                565                 570                 575     


Ala Ala Gly Cys Cys Ala Gly Gly Cys Cys Ala Gly Thr Cys Thr Cys 
            580                 585                 590         


Cys Cys Ala Ala Ala Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala 
        595                 600                 605             


Thr Ala Ala Gly Gly Thr Gly Ala Gly Cys Ala Ala Cys Cys Gly Gly 
    610                 615                 620                 


Thr Thr Cys Thr Cys Cys Gly Gly Gly Gly Thr Cys Cys Cys Thr Gly 
625                 630                 635                 640 


Ala Cys Ala Gly Ala Thr Thr Thr Thr Cys Thr Gly Gly Ala Ala Gly 
                645                 650                 655     


Thr Gly Gly Cys Thr Cys Ala Gly Gly Gly Ala Cys Ala Gly Ala Thr 
            660                 665                 670         


Thr Thr Cys Ala Cys Thr Cys Thr Gly Ala Ala Ala Ala Thr Thr Ala 
        675                 680                 685             


Gly Cys Ala Gly Ala Gly Thr Gly Gly Ala Gly Gly Cys Cys Gly Ala 
    690                 695                 700                 


Ala Gly Ala Thr Cys Thr Gly Gly Gly Cys Gly Thr Cys Thr Ala Cys 
705                 710                 715                 720 


Thr Thr Thr Thr Gly Thr Ala Gly Cys Cys Ala Gly Ala Ala Thr Ala 
                725                 730                 735     


Cys Cys Cys Ala Cys Gly Thr Cys Cys Cys Ala Cys Cys Ala Ala Cys 
            740                 745                 750         


Ala Thr Thr Cys Gly Gly Ala Ala Gly Cys Gly Gly Cys Ala Cys Thr 
        755                 760                 765             


Ala Ala Ala Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Gly 
    770                 775                 780             


<210>  3
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Lys Trp Ile Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
        195                 200                 205             


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 


Phe Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Arg 
    290                 295                 300                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
305                 310                 315                 320 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                325                 330                 335     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            340                 345                 350         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        355                 360                 365             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    370                 375                 380                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
385                 390                 395                 400 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410                 415 


<210>  4
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  5
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile 
            20                  


<210>  6
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  6
atggattgga tttggcgcat tctgtttctg gtgggagccg caaccggagc acatagtcag       60

gtccagctgc agcagtcagg agccgaactg gtgcggcccg gcgcaagtgt caaactgtca      120

tgcaaggcca gcgggtatac cttcacagac tacgagatgc actgggtgaa acagacccct      180

gtgcacggcc tgaagtggat cggcgctctg gacccaaaaa ccggggatac agcatattcc      240

cagaagttta aaggaaaggc cactctgacc gctgacaaga gctcctctac tgcctacatg      300

gagctgagga gcctgacatc cgaagatagc gccgtgtact attgcacccg cttctactcc      360

tatacatact ggggccaggg gactctggtg accgtctctg caggaggagg aggctctgga      420

ggaggaggga gtggaggcgg gggaagcgac gtggtcatga cacagactcc actgtccctg      480

cccgtgagcc tgggcgatca ggctagcatt tcctgtcgaa gttcacagag tctggtgcac      540

tcaaacggaa atacctatct gcattggtac ctgcagaagc caggccagtc tcccaaactg      600

ctgatctata aggtgagcaa ccggttctcc ggggtccctg acagattttc tggaagtggc      660

tcagggacag atttcactct gaaaattagc agagtggagg ccgaagatct gggcgtctac      720

ttttgtagcc agaataccca cgtcccacca acattcggaa gcggcactaa actggaaatc      780

aaggagccca aatcttgtga caaaactcac acatgcccac cgtgcccgga tccgaaagat      840

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattattag agtgaagttc agcaggagcg cagacgcccc cgcgtaccag      960

cagggccaga accagctcta taacgagctc aatctaggac gaagagagga gtacgatgtt     1020

ttggacaaga gacgtggccg ggaccctgag atggggggaa agccgagaag gaagaaccct     1080

caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt     1140

gggatgaaag gcgagcgccg gaggggcaag gggcacgatg gcctttacca gggtctcagt     1200

acagccacca aggacaccta cgacgccctt cacatgcagg ccctgccccc tcgc           1254


<210>  7
<211>  54
<212>  DNA
<213>  Homo sapiens

<400>  7
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccggatcc gaaa             54


<210>  8
<211>  9
<212>  DNA
<213>  Homo sapiens

<400>  8
gatcccaaa                                                                9


<210>  9
<211>  72
<212>  DNA
<213>  Homo sapiens

<400>  9
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta tt                                                           72


<210>  10
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Lys Trp Ile Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
        195                 200                 205             


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 


Phe Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210>  11
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  11

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser 
            20                  25                  30          


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        35                  40                  45              


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    50                  55                  60                  


Ala Tyr Arg Ser 
65              


<210>  12
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  12
atggattgga tttggcgcat tctgtttctg gtgggagccg caaccggagc acatagtcag       60

gtccagctgc agcagtcagg agccgaactg gtgcggcccg gcgcaagtgt caaactgtca      120

tgcaaggcca gcgggtatac cttcacagac tacgagatgc actgggtgaa acagacccct      180

gtgcacggcc tgaagtggat cggcgctctg gacccaaaaa ccggggatac agcatattcc      240

cagaagttta aaggaaaggc cactctgacc gctgacaaga gctcctctac tgcctacatg      300

gagctgagga gcctgacatc cgaagatagc gccgtgtact attgcacccg cttctactcc      360

tatacatact ggggccaggg gactctggtg accgtctctg caggaggagg aggctctgga      420

ggaggaggga gtggaggcgg gggaagcgac gtggtcatga cacagactcc actgtccctg      480

cccgtgagcc tgggcgatca ggctagcatt tcctgtcgaa gttcacagag tctggtgcac      540

tcaaacggaa atacctatct gcattggtac ctgcagaagc caggccagtc tcccaaactg      600

ctgatctata aggtgagcaa ccggttctcc ggggtccctg acagattttc tggaagtggc      660

tcagggacag atttcactct gaaaattagc agagtggagg ccgaagatct gggcgtctac      720

ttttgtagcc agaataccca cgtcccacca acattcggaa gcggcactaa actggaaatc      780

aaggagccca aatcttgtga caaaactcac acatgcccac cgtgcccgga tccgaaagat      840

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgtacaat gaactgcaga aagataagat ggcggaggcc     1260

tacagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggcctttac     1320

cagggtctca gtacagccac caaggacacc tacgacgccc ttcacatgca ggccctgccc     1380

cctcgc                                                                1386


<210>  13
<211>  204
<212>  DNA
<213>  Homo sapiens

<400>  13
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg      120

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca      180

cgcgacttcg cagcctatcg ctcc                                             204


<210>  14
<211>  457
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Lys Trp Ile Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
        195                 200                 205             


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 


Phe Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Lys 
    290                 295                 300                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
305                 310                 315                 320 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                325                 330                 335     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            340                 345                 350         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        355                 360                 365             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    370                 375                 380                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
385                 390                 395                 400 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                405                 410                 415     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            420                 425                 430         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        435                 440                 445             


Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455         


<210>  15
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  15

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  16
<211>  1380
<212>  DNA
<213>  Homo sapiens

<400>  16
atggattgga tttggcgcat tctgtttctg gtgggagccg caaccggagc acatagtcag       60

gtccagctgc agcagtcagg agccgaactg gtgcggcccg gcgcaagtgt caaactgtca      120

tgcaaggcca gcgggtatac cttcacagac tacgagatgc actgggtgaa acagacccct      180

gtgcacggcc tgaagtggat cggcgctctg gacccaaaaa ccggggatac agcatattcc      240

cagaagttta aaggaaaggc cactctgacc gctgacaaga gctcctctac tgcctacatg      300

gagctgagga gcctgacatc cgaagatagc gccgtgtact attgcacccg cttctactcc      360

tatacatact ggggccaggg gactctggtg accgtctctg caggaggagg aggctctgga      420

ggaggaggga gtggaggcgg gggaagcgac gtggtcatga cacagactcc actgtccctg      480

cccgtgagcc tgggcgatca ggctagcatt tcctgtcgaa gttcacagag tctggtgcac      540

tcaaacggaa atacctatct gcattggtac ctgcagaagc caggccagtc tcccaaactg      600

ctgatctata aggtgagcaa ccggttctcc ggggtccctg acagattttc tggaagtggc      660

tcagggacag atttcactct gaaaattagc agagtggagg ccgaagatct gggcgtctac      720

ttttgtagcc agaataccca cgtcccacca acattcggaa gcggcactaa actggaaatc      780

aaggagccca aatcttgtga caaaactcac acatgcccac cgtgcccgga tccgaaagat      840

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattattaa acggggcaga aagaaactcc tgtatatatt caaacaacca      960

tttatgagac cagtacaaac tactcaagag gaagatggct gtagctgccg atttccagaa     1020

gaagaagaag gaggatgtga actgagagtg aagttcagca ggagcgcaga cgcccccgcg     1080

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1140

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1200

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1260

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1320

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     1380


<210>  17
<211>  126
<212>  DNA
<213>  Homo sapiens

<400>  17
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag accagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  18
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Lys Trp Ile Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
145                 150                 155                 160 


Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
                165                 170                 175     


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
        195                 200                 205             


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
225                 230                 235                 240 


Phe Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
            260                 265                 270         


Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210>  19
<211>  1512
<212>  DNA
<213>  Homo sapiens

<400>  19
atggattgga tttggcgcat tctgtttctg gtgggagccg caaccggagc acatagtcag       60

gtccagctgc agcagtcagg agccgaactg gtgcggcccg gcgcaagtgt caaactgtca      120

tgcaaggcca gcgggtatac cttcacagac tacgagatgc actgggtgaa acagacccct      180

gtgcacggcc tgaagtggat cggcgctctg gacccaaaaa ccggggatac agcatattcc      240

cagaagttta aaggaaaggc cactctgacc gctgacaaga gctcctctac tgcctacatg      300

gagctgagga gcctgacatc cgaagatagc gccgtgtact attgcacccg cttctactcc      360

tatacatact ggggccaggg gactctggtg accgtctctg caggaggagg aggctctgga      420

ggaggaggga gtggaggcgg gggaagcgac gtggtcatga cacagactcc actgtccctg      480

cccgtgagcc tgggcgatca ggctagcatt tcctgtcgaa gttcacagag tctggtgcac      540

tcaaacggaa atacctatct gcattggtac ctgcagaagc caggccagtc tcccaaactg      600

ctgatctata aggtgagcaa ccggttctcc ggggtccctg acagattttc tggaagtggc      660

tcagggacag atttcactct gaaaattagc agagtggagg ccgaagatct gggcgtctac      720

ttttgtagcc agaataccca cgtcccacca acattcggaa gcggcactaa actggaaatc      780

aaggagccca aatcttgtga caaaactcac acatgcccac cgtgcccgga tccgaaagat      840

cccaaatttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc aaacggggca gaaagaaact cctgtatata     1080

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     1140

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     1200

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     1260

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     1320

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     1380

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     1440

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     1500

ctgccccctc gc                                                         1512


<210>  20
<211>  344
<212>  DNA
<213>  Homo sapiens

<400>  20
caggtccagc tgcagcagtc aggagccgaa ctggtgcggc ccggcgcaag tgtcaaactg       60

tcatgcaagg ccagcgggta taccttcaca gactacgaga tgcactgggt gaaacagacc      120

cctgtgcacg gcctgaagtg gatcggcgct ctggacccaa aaaccgggga tacagcatat      180

tcccagaagt ttaaaggaaa ggccactctg accgctgaca agagctcctc tactgcctac      240

atggagctga ggagcctgac atccgaagat agcgccgtgt actattgcac ccgcttctac      300

tcctatacat actggggcca ggggactctg gtgaccgtct ctgc                       344


<210>  21
<211>  335
<212>  DNA
<213>  Homo sapiens

<400>  21
gacgtggtca tgacacagac tccactgtcc ctgcccgtga gcctgggcga tcaggctagc       60

atttcctgtc gaagttcaca gagtctggtg cactcaaacg gaaataccta tctgcattgg      120

tacctgcaga agccaggcca gtctcccaaa ctgctgatct ataaggtgag caaccggttc      180

tccggggtcc ctgacagatt ttctggaagt ggctcaggga cagatttcac tctgaaaatt      240

agcagagtgg aggccgaaga tctgggcgtc tacttttgta gccagaatac ccacgtccca      300

ccaacattcg gaagcggcac taaactggaa atcaa                                 335


<210>  22
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  23
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  24
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  24

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
    210                 215                 220                 


Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  25
<211>  726
<212>  DNA
<213>  Homo sapiens

<400>  25
caggtccagc tgcagcagtc aggagccgaa ctggtgcggc ccggcgcaag tgtcaaactg       60

tcatgcaagg ccagcgggta taccttcaca gactacgaga tgcactgggt gaaacagacc      120

cctgtgcacg gcctgaagtg gatcggcgct ctggacccaa aaaccgggga tacagcatat      180

tcccagaagt ttaaaggaaa ggccactctg accgctgaca agagctcctc tactgcctac      240

atggagctga ggagcctgac atccgaagat agcgccgtgt actattgcac ccgcttctac      300

tcctatacat actggggcca ggggactctg gtgaccgtct ctgcaggagg aggaggctct      360

ggaggaggag ggagtggagg cgggggaagc gacgtggtca tgacacagac tccactgtcc      420

ctgcccgtga gcctgggcga tcaggctagc atttcctgtc gaagttcaca gagtctggtg      480

cactcaaacg gaaataccta tctgcattgg tacctgcaga agccaggcca gtctcccaaa      540

ctgctgatct ataaggtgag caaccggttc tccggggtcc ctgacagatt ttctggaagt      600

ggctcaggga cagatttcac tctgaaaatt agcagagtgg aggccgaaga tctgggcgtc      660

tacttttgta gccagaatac ccacgtccca ccaacattcg gaagcggcac taaactggaa      720

atcaag                                                                 726


<210>  26
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  26

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
    210                 215                 220                 


Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            260                 265                 270         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Arg Val Lys Phe 
        275                 280                 285             


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
    290                 295                 300                 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
305                 310                 315                 320 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
                325                 330                 335     


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
            340                 345                 350         


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
        355                 360                 365             


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
    370                 375                 380                 


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395     


<210>  27
<211>  1197
<212>  DNA
<213>  Homo sapiens

<400>  27
caggtccagc tgcagcagtc aggagccgaa ctggtgcggc ccggcgcaag tgtcaaactg       60

tcatgcaagg ccagcgggta taccttcaca gactacgaga tgcactgggt gaaacagacc      120

cctgtgcacg gcctgaagtg gatcggcgct ctggacccaa aaaccgggga tacagcatat      180

tcccagaagt ttaaaggaaa ggccactctg accgctgaca agagctcctc tactgcctac      240

atggagctga ggagcctgac atccgaagat agcgccgtgt actattgcac ccgcttctac      300

tcctatacat actggggcca ggggactctg gtgaccgtct ctgcaggagg aggaggctct      360

ggaggaggag ggagtggagg cgggggaagc gacgtggtca tgacacagac tccactgtcc      420

ctgcccgtga gcctgggcga tcaggctagc atttcctgtc gaagttcaca gagtctggtg      480

cactcaaacg gaaataccta tctgcattgg tacctgcaga agccaggcca gtctcccaaa      540

ctgctgatct ataaggtgag caaccggttc tccggggtcc ctgacagatt ttctggaagt      600

ggctcaggga cagatttcac tctgaaaatt agcagagtgg aggccgaaga tctgggcgtc      660

tacttttgta gccagaatac ccacgtccca ccaacattcg gaagcggcac taaactggaa      720

atcaaggagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc ggatccgaaa      780

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      840

gtaacagtgg cctttattat tagagtgaag ttcagcagga gcgcagacgc ccccgcgtac      900

cagcagggcc agaaccagct ctataacgag ctcaatctag gacgaagaga ggagtacgat      960

gttttggaca agagacgtgg ccgggaccct gagatggggg gaaagccgag aaggaagaac     1020

cctcaggaag gcctgtacaa tgaactgcag aaagataaga tggcggaggc ctacagtgag     1080

attgggatga aaggcgagcg ccggaggggc aaggggcacg atggccttta ccagggtctc     1140

agtacagcca ccaaggacac ctacgacgcc cttcacatgc aggccctgcc ccctcgc        1197


<210>  28
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  28

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
    210                 215                 220                 


Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            260                 265                 270         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        275                 280                 285             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    290                 295                 300                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
305                 310                 315                 320 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                325                 330                 335     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            340                 345                 350         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        355                 360                 365             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    370                 375                 380                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
385                 390                 395                 400 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                405                 410                 415     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            420                 425                 430         


His Met Gln Ala Leu Pro Pro Arg 
        435                 440 


<210>  29
<211>  1329
<212>  DNA
<213>  Homo sapiens

<400>  29
caggtccagc tgcagcagtc aggagccgaa ctggtgcggc ccggcgcaag tgtcaaactg       60

tcatgcaagg ccagcgggta taccttcaca gactacgaga tgcactgggt gaaacagacc      120

cctgtgcacg gcctgaagtg gatcggcgct ctggacccaa aaaccgggga tacagcatat      180

tcccagaagt ttaaaggaaa ggccactctg accgctgaca agagctcctc tactgcctac      240

atggagctga ggagcctgac atccgaagat agcgccgtgt actattgcac ccgcttctac      300

tcctatacat actggggcca ggggactctg gtgaccgtct ctgcaggagg aggaggctct      360

ggaggaggag ggagtggagg cgggggaagc gacgtggtca tgacacagac tccactgtcc      420

ctgcccgtga gcctgggcga tcaggctagc atttcctgtc gaagttcaca gagtctggtg      480

cactcaaacg gaaataccta tctgcattgg tacctgcaga agccaggcca gtctcccaaa      540

ctgctgatct ataaggtgag caaccggttc tccggggtcc ctgacagatt ttctggaagt      600

ggctcaggga cagatttcac tctgaaaatt agcagagtgg aggccgaaga tctgggcgtc      660

tacttttgta gccagaatac ccacgtccca ccaacattcg gaagcggcac taaactggaa      720

atcaaggagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc ggatccgaaa      780

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      840

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt      900

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      960

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1020

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1080

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1140

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1200

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1260

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1320

ccccctcgc                                                             1329


<210>  30
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
    210                 215                 220                 


Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            260                 265                 270         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Lys Arg Gly Arg 
        275                 280                 285             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    290                 295                 300                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  31
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  31
caggtccagc tgcagcagtc aggagccgaa ctggtgcggc ccggcgcaag tgtcaaactg       60

tcatgcaagg ccagcgggta taccttcaca gactacgaga tgcactgggt gaaacagacc      120

cctgtgcacg gcctgaagtg gatcggcgct ctggacccaa aaaccgggga tacagcatat      180

tcccagaagt ttaaaggaaa ggccactctg accgctgaca agagctcctc tactgcctac      240

atggagctga ggagcctgac atccgaagat agcgccgtgt actattgcac ccgcttctac      300

tcctatacat actggggcca ggggactctg gtgaccgtct ctgcaggagg aggaggctct      360

ggaggaggag ggagtggagg cgggggaagc gacgtggtca tgacacagac tccactgtcc      420

ctgcccgtga gcctgggcga tcaggctagc atttcctgtc gaagttcaca gagtctggtg      480

cactcaaacg gaaataccta tctgcattgg tacctgcaga agccaggcca gtctcccaaa      540

ctgctgatct ataaggtgag caaccggttc tccggggtcc ctgacagatt ttctggaagt      600

ggctcaggga cagatttcac tctgaaaatt agcagagtgg aggccgaaga tctgggcgtc      660

tacttttgta gccagaatac ccacgtccca ccaacattcg gaagcggcac taaactggaa      720

atcaaggagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc ggatccgaaa      780

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      840

gtaacagtgg cctttattat taaacggggc agaaagaaac tcctgtatat attcaaacaa      900

ccatttatga gaccagtaca aactactcaa gaggaagatg gctgtagctg ccgatttcca      960

gaagaagaag aaggaggatg tgaactgaga gtgaagttca gcaggagcgc agacgccccc     1020

gcgtaccagc agggccagaa ccagctctat aacgagctca atctaggacg aagagaggag     1080

tacgatgttt tggacaagag acgtggccgg gaccctgaga tggggggaaa gccgagaagg     1140

aagaaccctc aggaaggcct gtacaatgaa ctgcagaaag ataagatggc ggaggcctac     1200

agtgagattg ggatgaaagg cgagcgccgg aggggcaagg ggcacgatgg cctttaccag     1260

ggtctcagta cagccaccaa ggacacctac gacgcccttc acatgcaggc cctgccccct     1320

cgc                                                                   1323


<210>  32
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  32

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Lys Trp Ile 
        35                  40                  45              


Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser 
    130                 135                 140                 


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
145                 150                 155                 160 


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
                165                 170                 175     


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
            180                 185                 190         


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser 
    210                 215                 220                 


Gln Asn Thr His Val Pro Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
            260                 265                 270         


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
        275                 280                 285             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    290                 295                 300                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
305                 310                 315                 320 


Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu 
                325                 330                 335     


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
            340                 345                 350         


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
        355                 360                 365             


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
    370                 375                 380                 


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
385                 390                 395                 400 


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
                405                 410                 415     


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
            420                 425                 430         


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
        435                 440                 445             


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
    450                 455                 460                 


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
465                 470                 475                 480 


Pro Arg 
        


<210>  33
<211>  1455
<212>  DNA
<213>  Homo sapiens

<400>  33
caggtccagc tgcagcagtc aggagccgaa ctggtgcggc ccggcgcaag tgtcaaactg       60

tcatgcaagg ccagcgggta taccttcaca gactacgaga tgcactgggt gaaacagacc      120

cctgtgcacg gcctgaagtg gatcggcgct ctggacccaa aaaccgggga tacagcatat      180

tcccagaagt ttaaaggaaa ggccactctg accgctgaca agagctcctc tactgcctac      240

atggagctga ggagcctgac atccgaagat agcgccgtgt actattgcac ccgcttctac      300

tcctatacat actggggcca ggggactctg gtgaccgtct ctgcaggagg aggaggctct      360

ggaggaggag ggagtggagg cgggggaagc gacgtggtca tgacacagac tccactgtcc      420

ctgcccgtga gcctgggcga tcaggctagc atttcctgtc gaagttcaca gagtctggtg      480

cactcaaacg gaaataccta tctgcattgg tacctgcaga agccaggcca gtctcccaaa      540

ctgctgatct ataaggtgag caaccggttc tccggggtcc ctgacagatt ttctggaagt      600

ggctcaggga cagatttcac tctgaaaatt agcagagtgg aggccgaaga tctgggcgtc      660

tacttttgta gccagaatac ccacgtccca ccaacattcg gaagcggcac taaactggaa      720

atcaaggagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc ggatccgaaa      780

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      840

gtaacagtgg cctttattat tttctgggtg aggagtaaga ggagcaggct cctgcacagt      900

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat      960

gccccaccac gcgacttcgc agcctatcgc tccaaacggg gcagaaagaa actcctgtat     1020

atattcaaac aaccatttat gagaccagta caaactactc aagaggaaga tggctgtagc     1080

tgccgatttc cagaagaaga agaaggagga tgtgaactga gagtgaagtt cagcaggagc     1140

gcagacgccc ccgcgtacca gcagggccag aaccagctct ataacgagct caatctagga     1200

cgaagagagg agtacgatgt tttggacaag agacgtggcc gggaccctga gatgggggga     1260

aagccgagaa ggaagaaccc tcaggaaggc ctgtacaatg aactgcagaa agataagatg     1320

gcggaggcct acagtgagat tgggatgaaa ggcgagcgcc ggaggggcaa ggggcacgat     1380

ggcctttacc agggtctcag tacagccacc aaggacacct acgacgccct tcacatgcag     1440

gccctgcccc ctcgc                                                      1455


