                               SEQUENCE LISTING

<110> IDERA PHARMACEUTICALS, INC.
 
<120> TREATMENT OF CANCER USING TLR9 AGONIST WITH CHECKPOINT 
      INHIBITORS

<130> 4204.3000 WO

<140> PCT/US2015/054899
<141> 2015-10-09

<150> 62/062,274
<151> 2014-10-24

<150> 62/218,934
<151> 2015-09-15

<160> 27    

<170> PatentIn version 3.5

<210> 1
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<400> 1
tctgacgttc t                                                            11


<210> 2
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<400> 2
tctgtcgttc t                                                            11


<210> 3
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-7-deazaguanosine

<400> 3
tcgtcgttct g                                                            11


<210> 4
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<400> 4
tcgaacgttc g                                                            11


<210> 5
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (5)..(6)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-arabinoguanosine

<400> 5
ctgtcgttct c                                                            11


<210> 6
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-arabinoguanosine

<220>
<221> misc_feature
<222> (11)..(11)
<223> Phosphodiester linkage to 3' linker

<400> 6
ctgtcgttct c                                                            11


<210> 7
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-arabinoguanosine

<400> 7
cagtcgttca g                                                            11


<210> 8
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-7-deazaguanosine

<400> 8
cagtcgttca g                                                            11


<210> 9
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methylguanosine

<400> 9
tcgaacgttc g                                                            11


<210> 10
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (8)..(9)
<223> Phosphodiester linkage

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methylguanosine

<400> 10
tcgaacgttc g                                                            11


<210> 11
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-arabinoguanosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-deoxy-arabinoguanosine

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-deoxy-uracil

<400> 11
tcgtcgttu                                                                9


<210> 12
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<400> 12
tcgtacgtac g                                                            11


<210> 13
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<400> 13
tcgaacgttc g                                                            11


<210> 14
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<400> 14
tcgaacgttc g                                                            11


<210> 15
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (7)..(8)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<400> 15
tcgaacgttc g                                                            11


<210> 16
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (2)..(4)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (11)..(11)
<223> Phosphodiester linkage to 3' linker

<400> 16
tcgaacgttc g                                                            11


<210> 17
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphodiester linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (11)..(11)
<223> Phosphodiester linkage to 3' linker

<400> 17
tcgaacgttc g                                                            11


<210> 18
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (2)..(4)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-arabinoguanosine

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-arabinoguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-arabinoguanosine

<220>
<221> misc_feature
<222> (11)..(11)
<223> Phosphodiester linkage to 3' linker

<400> 18
tcgaacgttc g                                                            11


<210> 19
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (2)..(4)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> misc_feature
<222> (11)..(11)
<223> Phosphodiester linkage to 3' linker

<400> 19
tcgaacgttc g                                                            11


<210> 20
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> misc_feature
<222> (1)..(2)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (3)..(4)
<223> Phosphodiester linkage

<220>
<221> misc_feature
<222> (6)..(7)
<223> Phosphodiester linkage

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> misc_feature
<222> (10)..(11)
<223> Phosphodiester linkage

<220>
<221> misc_feature
<222> (11)..(11)
<223> Phosphodiester linkage to 3' linker

<400> 20
tcgaacgttc g                                                            11


<210> 21
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-arabinoguanosine

<400> 21
tctgtcgttc t                                                            11


<210> 22
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<400> 22
tctgtcgaca g                                                            11


<210> 23
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methylcytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<400> 23
tcgttctgtc gttct                                                        15


<210> 24
<211> 11
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyluracil

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-deoxy-7-deazaguanosine

<400> 24
tcugtcgttc t                                                            11


<210> 25
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-O-Methylcytosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<400> 25
tcgttctgtc gttgt                                                        15


<210> 26
<211> 14
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-arabinoguanosine

<400> 26
tcgttcagtc gttc                                                         14


<210> 27
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-deoxy-7-deazaguanosine

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-deoxy-7-deazaguanosine

<400> 27
tcgttctgtc gttac                                                        15


