                         SEQUENCE LISTING

<110>  Vaxart, Inc.
       Scallan, Ciaran
       Peters, Wendy
 
<120>  HSV Vaccines

<130>  90402-960670-001500WO

<140>  PCT/US2015-054929
<141>  2015-10-09

<150>  US 62/062,692
<151>  2014-10-24

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  824
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic protein ofr HSV2 ICP0 with RING domain

<400>  1

Met Glu Pro Arg Pro Gly Thr Ser Ser Arg Ala Asp Pro Gly Pro Glu 
1               5                   10                  15      


Arg Pro Pro Arg Gln Thr Pro Gly Thr Pro Ala Ala Pro His Ala Trp 
            20                  25                  30          


Gly Met Leu Asn Asp Met Gln Trp Leu Ala Ser Ser Asp Ser Glu Glu 
        35                  40                  45              


Glu Thr Glu Val Gly Ile Ser Asp Asp Asp Leu His Arg Asp Ser Thr 
    50                  55                  60                  


Ser Glu Ala Gly Ser Thr Asp Thr Glu Met Phe Glu Ala Gly Leu Met 
65                  70                  75                  80  


Asp Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala Glu Arg Gln Gly Ser 
                85                  90                  95      


Pro Thr Pro Ala Asp Ala Gln Gly Ser Cys Gly Gly Gly Pro Val Gly 
            100                 105                 110         


Glu Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp Val Cys Ala Val Cys 
        115                 120                 125             


Thr Asp Glu Ile Ala Pro Pro Leu Arg Cys Gln Ser Phe Pro Cys Leu 
    130                 135                 140                 


His Pro Phe Cys Ile Pro Cys Met Lys Thr Trp Ile Pro Leu Arg Asn 
145                 150                 155                 160 


Thr Cys Pro Leu Cys Asn Thr Pro Val Ala Tyr Leu Ile Val Gly Val 
                165                 170                 175     


Thr Ala Ser Gly Ser Phe Ser Thr Ile Pro Ile Val Asn Asp Pro Arg 
            180                 185                 190         


Thr Arg Val Glu Ala Glu Ala Ala Val Arg Ala Gly Thr Ala Val Asp 
        195                 200                 205             


Phe Ile Trp Thr Gly Asn Pro Arg Thr Ala Pro Arg Ser Leu Ser Leu 
    210                 215                 220                 


Gly Gly His Thr Val Arg Ala Leu Ser Pro Thr Pro Pro Trp Pro Gly 
225                 230                 235                 240 


Thr Asp Asp Glu Asp Asp Asp Leu Ala Asp Val Asp Tyr Val Pro Pro 
                245                 250                 255     


Ala Pro Arg Arg Ala Pro Arg Arg Gly Gly Gly Gly Ala Gly Ala Thr 
            260                 265                 270         


Arg Gly Thr Ser Gln Pro Ala Ala Thr Arg Pro Ala Pro Pro Gly Ala 
        275                 280                 285             


Pro Arg Ser Ser Ser Ser Gly Gly Ala Pro Leu Arg Ala Gly Val Gly 
    290                 295                 300                 


Ser Gly Ser Gly Gly Gly Pro Ala Val Ala Ala Val Val Pro Arg Val 
305                 310                 315                 320 


Ala Ser Leu Pro Pro Ala Ala Gly Gly Gly Arg Ala Gln Ala Arg Arg 
                325                 330                 335     


Val Gly Glu Asp Ala Ala Ala Ala Glu Gly Arg Thr Pro Pro Ala Arg 
            340                 345                 350         


Gln Pro Arg Ala Ala Gln Glu Pro Pro Ile Val Ile Ser Asp Ser Pro 
        355                 360                 365             


Pro Pro Ser Pro Arg Arg Pro Ala Gly Pro Gly Pro Leu Ser Phe Val 
    370                 375                 380                 


Ser Ser Ser Ser Ala Gln Val Ser Ser Gly Pro Gly Gly Gly Gly Leu 
385                 390                 395                 400 


Pro Gln Ser Ser Gly Arg Ala Ala Arg Pro Arg Ala Ala Val Ala Pro 
                405                 410                 415     


Arg Val Arg Ser Pro Pro Arg Ala Ala Ala Ala Pro Val Val Ser Ala 
            420                 425                 430         


Ser Ala Asp Ala Ala Gly Pro Ala Pro Pro Ala Val Pro Val Asp Ala 
        435                 440                 445             


His Arg Ala Pro Arg Ser Arg Met Thr Gln Ala Gln Thr Asp Thr Gln 
    450                 455                 460                 


Ala Gln Ser Leu Gly Arg Ala Gly Ala Thr Asp Ala Arg Gly Ser Gly 
465                 470                 475                 480 


Gly Pro Gly Ala Glu Gly Gly Pro Gly Val Pro Arg Gly Thr Asn Thr 
                485                 490                 495     


Pro Gly Ala Ala Pro His Ala Ala Glu Gly Ala Ala Ala Arg Pro Arg 
            500                 505                 510         


Lys Arg Arg Gly Ser Asp Ser Gly Pro Ala Ala Ser Ser Ser Ala Ser 
        515                 520                 525             


Ser Ser Ala Ala Pro Arg Ser Pro Leu Ala Pro Gln Gly Val Gly Ala 
    530                 535                 540                 


Lys Arg Ala Ala Pro Arg Arg Ala Pro Asp Ser Asp Ser Gly Asp Arg 
545                 550                 555                 560 


Gly His Gly Pro Leu Ala Pro Ala Ser Ala Gly Ala Ala Pro Pro Ser 
                565                 570                 575     


Ala Ser Pro Ser Ser Gln Ala Ala Val Ala Ala Ala Ser Ser Ser Ser 
            580                 585                 590         


Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala 
        595                 600                 605             


Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser 
    610                 615                 620                 


Ser Ser Ala Gly Gly Ala Gly Gly Ser Val Ala Ser Ala Ser Gly Ala 
625                 630                 635                 640 


Gly Glu Arg Arg Glu Thr Ser Leu Gly Pro Arg Ala Ala Ala Pro Arg 
                645                 650                 655     


Gly Pro Arg Lys Cys Ala Arg Lys Thr Arg His Ala Glu Gly Gly Pro 
            660                 665                 670         


Glu Pro Gly Ala Arg Asp Pro Ala Pro Gly Leu Thr Arg Tyr Leu Pro 
        675                 680                 685             


Ile Ala Gly Val Ser Ser Val Val Ala Leu Ala Pro Tyr Val Asn Lys 
    690                 695                 700                 


Thr Val Thr Gly Asp Cys Leu Pro Val Leu Asp Met Glu Thr Gly His 
705                 710                 715                 720 


Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly Asn Val Ala Asp 
                725                 730                 735     


Leu Leu Arg Ala Ala Ala Pro Ala Trp Ser Arg Arg Thr Leu Leu Pro 
            740                 745                 750         


Glu His Ala Arg Asn Cys Val Arg Pro Pro Asp Tyr Pro Thr Pro Pro 
        755                 760                 765             


Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val Gly Asn Met Leu 
    770                 775                 780                 


Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe His Gly Leu Arg 
785                 790                 795                 800 


Ser Arg His Pro Trp Ser Arg Glu Gln Gly Ala Pro Ala Pro Ala Gly 
                805                 810                 815     


Asp Ala Pro Ala Gly His Gly Glu 
            820                 


<210>  2
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic protein of HSV2 ICP0 Mutant #1 (mICP0)

<400>  2

Met Glu Pro Arg Pro Gly Thr Ser Ser Arg Ala Asp Pro Gly Pro Glu 
1               5                   10                  15      


Arg Pro Pro Arg Gln Thr Pro Gly Thr Pro Ala Ala Pro His Ala Trp 
            20                  25                  30          


Gly Met Leu Asn Asp Met Gln Trp Leu Ala Ser Ser Asp Ser Glu Glu 
        35                  40                  45              


Glu Thr Glu Val Gly Ile Ser Asp Asp Asp Leu His Arg Asp Ser Thr 
    50                  55                  60                  


Ser Glu Ala Gly Ser Thr Asp Thr Glu Met Phe Glu Ala Gly Leu Met 
65                  70                  75                  80  


Asp Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala Glu Arg Gln Gly Ser 
                85                  90                  95      


Pro Thr Pro Ala Asp Ala Gln Gly Ser Cys Gly Gly Gly Pro Val Gly 
            100                 105                 110         


Glu Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp Val Cys Ala Val Cys 
        115                 120                 125             


Thr Asp Glu Ile Ala Pro Leu Thr Ala Ser Gly Ser Phe Ser Thr Ile 
    130                 135                 140                 


Pro Ile Val Asn Asp Pro Arg Thr Arg Val Glu Ala Glu Ala Ala Val 
145                 150                 155                 160 


Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Pro Arg Thr 
                165                 170                 175     


Ala Pro Arg Ser Leu Ser Leu Gly Gly His Thr Val Arg Ala Leu Ser 
            180                 185                 190         


Pro Thr Pro Pro Trp Pro Gly Thr Asp Asp Glu Asp Asp Asp Leu Ala 
        195                 200                 205             


Asp Val Asp Tyr Val Pro Pro Ala Pro Arg Arg Ala Pro Arg Arg Gly 
    210                 215                 220                 


Gly Gly Gly Ala Gly Ala Thr Arg Gly Thr Ser Gln Pro Ala Ala Thr 
225                 230                 235                 240 


Arg Pro Ala Pro Pro Gly Ala Pro Arg Ser Ser Ser Ser Gly Gly Ala 
                245                 250                 255     


Pro Leu Arg Ala Gly Val Gly Ser Gly Ser Gly Gly Gly Pro Ala Val 
            260                 265                 270         


Ala Ala Val Val Pro Arg Val Ala Ser Leu Pro Pro Ala Ala Gly Gly 
        275                 280                 285             


Gly Arg Ala Gln Ala Arg Arg Val Gly Glu Asp Ala Ala Ala Ala Glu 
    290                 295                 300                 


Gly Arg Thr Pro Pro Ala Arg Gln Pro Arg Ala Ala Gln Glu Pro Pro 
305                 310                 315                 320 


Ile Val Ile Ser Asp Ser Pro Pro Pro Ser Pro Arg Arg Pro Ala Gly 
                325                 330                 335     


Pro Gly Pro Leu Ser Phe Val Ser Ser Ser Ser Ala Gln Val Ser Ser 
            340                 345                 350         


Gly Pro Gly Gly Gly Gly Leu Pro Gln Ser Ser Gly Arg Ala Ala Arg 
        355                 360                 365             


Pro Arg Ala Ala Val Ala Pro Arg Val Arg Ser Pro Pro Arg Ala Ala 
    370                 375                 380                 


Ala Ala Pro Val Val Ser Ala Ser Ala Asp Ala Ala Gly Pro Ala Pro 
385                 390                 395                 400 


Pro Ala Val Pro Val Asp Ala His Arg Ala Pro Arg Ser Arg Met Thr 
                405                 410                 415     


Gln Ala Gln Thr Asp Thr Gln Ala Gln Ser Leu Gly Arg Ala Gly Ala 
            420                 425                 430         


Thr Asp Ala Arg Gly Ser Gly Gly Pro Gly Ala Glu Gly Gly Pro Gly 
        435                 440                 445             


Val Pro Arg Gly Thr Asn Thr Pro Gly Ala Ala Pro His Ala Ala Glu 
    450                 455                 460                 


Gly Ala Ala Ala Arg Pro Arg Lys Arg Arg Gly Ser Asp Ser Gly Pro 
465                 470                 475                 480 


Ala Ala Ser Ser Ser Ala Ser Ser Ser Ala Ala Pro Arg Ser Pro Leu 
                485                 490                 495     


Ala Pro Gln Gly Val Gly Ala Lys Arg Ala Ala Pro Arg Arg Ala Pro 
            500                 505                 510         


Asp Ser Asp Ser Gly Asp Arg Gly His Gly Pro Leu Ala Pro Ala Ser 
        515                 520                 525             


Ala Gly Ala Ala Pro Pro Ser Ala Ser Pro Ser Ser Gln Ala Ala Val 
    530                 535                 540                 


Ala Ala Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser 
545                 550                 555                 560 


Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser 
                565                 570                 575     


Ala Ser Ser Ser Ser Ala Ser Ser Ser Ala Gly Gly Ala Gly Gly Ser 
            580                 585                 590         


Val Ala Ser Ala Ser Gly Ala Gly Glu Arg Arg Glu Thr Ser Leu Gly 
        595                 600                 605             


Pro Arg Ala Ala Ala Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys Thr 
    610                 615                 620                 


Arg His Ala Glu Gly Gly Pro Glu Pro Gly Ala Arg Asp Pro Ala Pro 
625                 630                 635                 640 


Gly Leu Thr Arg Tyr Leu Pro Ile Ala Gly Val Ser Ser Val Val Ala 
                645                 650                 655     


Leu Ala Pro Tyr Val Asn Lys Thr Val Thr Gly Asp Cys Leu Pro Val 
            660                 665                 670         


Leu Asp Met Glu Thr Gly His Ile Gly Ala Tyr Val Val Leu Val Asp 
        675                 680                 685             


Gln Thr Gly Asn Val Ala Asp Leu Leu Arg Ala Ala Ala Pro Ala Trp 
    690                 695                 700                 


Ser Arg Arg Thr Leu Leu Pro Glu His Ala Arg Asn Cys Val Arg Pro 
705                 710                 715                 720 


Pro Asp Tyr Pro Thr Pro Pro Ala Ser Glu Trp Asn Ser Leu Trp Met 
                725                 730                 735     


Thr Pro Val Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala 
            740                 745                 750         


Leu Asp Phe His Gly Leu Arg Ser Arg His Pro Trp Ser Arg Glu Gln 
        755                 760                 765             


Gly Ala Pro Ala Pro Ala Gly Asp Ala Pro Ala Gly His Gly Glu 
    770                 775                 780             


<210>  3
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic protein of HSV1 ICP0 Mutant #2 (m2ICP0)

<400>  3

His Arg Asp Ser Thr Ser Glu Ala Gly Ser Thr Asp Thr Glu Met Phe 
1               5                   10                  15      


Glu Ala Gly Leu Met Asp Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala 
            20                  25                  30          


Glu Arg Gln Gly Ser Pro Thr Pro Ala Asp Ala Gln Gly Ser Cys Gly 
        35                  40                  45              


Gly Gly Pro Val Gly Glu Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp 
    50                  55                  60                  


Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro Pro Leu Arg Cys Gln 
65                  70                  75                  80  


Ser Phe Pro Cys Leu His Pro Phe Cys Ile Pro Asn Thr Pro Val Ala 
                85                  90                  95      


Tyr Leu Ile Val Gly Val Thr Ala Ser Gly Ser Phe Ser Thr Ile Pro 
            100                 105                 110         


Ile Val Asn Asp Pro Arg Thr Arg Val Glu Ala Glu Ala Ala Val Arg 
        115                 120                 125             


Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Pro Arg Thr Ala 
    130                 135                 140                 


Pro Arg Ser Leu Ser Leu Gly Gly His Thr Val Arg Ala Leu Ser Pro 
145                 150                 155                 160 


Thr Pro Pro Trp Pro Gly Thr Asp Asp Glu Asp Asp Asp Leu Ala Asp 
                165                 170                 175     


Val Asp Tyr Val Pro Pro Ala Pro Arg Arg Ala Pro Arg Arg Gly Gly 
            180                 185                 190         


Gly Gly Ala Gly Ala Thr Arg Gly Thr Ser Gln Pro Ala Ala Thr Arg 
        195                 200                 205             


Pro Ala Pro Pro Gly Ala Pro Arg Ser Ser Ser Ser Gly Gly Ala Pro 
    210                 215                 220                 


Leu Arg Ala Gly Val Gly Ser Gly Ser Gly Gly Gly Pro Ala Val Ala 
225                 230                 235                 240 


Ala Val Val Pro Arg Val Ala Ser Leu Pro Pro Ala Ala Gly Gly Gly 
                245                 250                 255     


Arg Ala Gln Ala Arg Arg Val Gly Glu Asp Ala Ala Ala Ala Glu Gly 
            260                 265                 270         


Arg Thr Pro Pro Ala Arg Gln Pro Arg Ala Ala Gln Glu Pro Pro Ile 
        275                 280                 285             


Val Ile Ser Asp Ser Pro Pro Pro Ser Pro Arg Arg Pro Ala Gly Pro 
    290                 295                 300                 


Gly Pro Leu Ser Phe Val Ser Ser Ser Ser Ala Gln Val Ser Ser Gly 
305                 310                 315                 320 


Pro Gly Gly Gly Gly Leu Pro Gln Ser Ser Gly Arg Ala Ala Arg Pro 
                325                 330                 335     


Arg Ala Ala Val Ala Pro Arg Val Arg Ser Pro Pro Arg Ala Ala Ala 
            340                 345                 350         


Ala Pro Val Val Ser Ala Ser Ala Asp Ala Ala Gly Pro Ala Pro Pro 
        355                 360                 365             


Ala Val Pro Val Asp Ala His Arg Ala Pro Arg Ser Arg Met Thr Gln 
    370                 375                 380                 


Ala Gln Thr Asp Thr Gln Ala Gln Ser Leu Gly Arg Ala Gly Ala Thr 
385                 390                 395                 400 


Asp Ala Arg Gly Ser Gly Gly Pro Gly Ala Glu Gly Gly Pro Gly Val 
                405                 410                 415     


Pro Arg Gly Thr Asn Thr Pro Gly Ala Ala Pro His Ala Ala Glu Gly 
            420                 425                 430         


Ala Ala Ala Arg Pro Arg Lys Arg Arg Gly Ser Asp Ser Gly Pro Ala 
        435                 440                 445             


Ala Ser Ser Ser Ala Ser Ser Ser Ala Ala Pro Arg Ser Pro Leu Ala 
    450                 455                 460                 


Pro Gln Gly Val Gly Ala Lys Arg Ala Ala Pro Arg Arg Ala Pro Asp 
465                 470                 475                 480 


Ser Asp Ser Gly Asp Arg Gly His Gly Pro Leu Ala Pro Ala Ser Ala 
                485                 490                 495     


Gly Ala Ala Pro Pro Ser Ala Ser Pro Ser Ser Gln Ala Ala Val Ala 
            500                 505                 510         


Ala Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser 
        515                 520                 525             


Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala 
    530                 535                 540                 


Ser Ser Ser Ser Ala Ser Ser Ser Ala Gly Gly Ala Gly Gly Ser Val 
545                 550                 555                 560 


Ala Ser Ala Ser Gly Ala Gly Glu Arg Arg Glu Thr Ser Leu Gly Pro 
                565                 570                 575     


Arg Ala Ala Ala Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys Thr Arg 
            580                 585                 590         


His Ala Glu Gly Gly Pro Glu Pro Gly Ala Arg Asp Pro Ala Pro Gly 
        595                 600                 605             


Leu Thr Arg Tyr Leu Pro Ile Ala Gly Val Ser Ser Val Val Ala Leu 
    610                 615                 620                 


Ala Pro Tyr Val Asn Lys Thr Val Thr Gly Asp Cys Leu Pro Val Leu 
625                 630                 635                 640 


Asp Met Glu Thr Gly His Ile Gly Ala Tyr Val Val Leu Val Asp Gln 
                645                 650                 655     


Thr Gly Asn Val Ala Asp Leu Leu Arg Ala Ala Ala Pro Ala Trp Ser 
            660                 665                 670         


Arg Arg Thr Leu Leu Pro Glu His Ala Arg Asn Cys Val Arg Pro Pro 
        675                 680                 685             


Asp Tyr Pro Thr Pro Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr 
    690                 695                 700                 


Pro Val Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu 
705                 710                 715                 720 


Asp Phe His Gly Leu Arg Ser Arg His Pro Trp Ser Arg Glu Gln Gly 
                725                 730                 735     


Ala Pro Ala Pro Ala Gly Asp Ala Pro Ala Gly His Gly Glu 
            740                 745                 750 


<210>  4
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic protein of HSV2 glycoprotein D for Ad-gD-Luc construct

<400>  4

Met Gly Arg Leu Thr Ser Gly Val Gly Thr Ala Ala Leu Leu Val Val 
1               5                   10                  15      


Ala Val Gly Leu Arg Val Val Cys Ala Lys Tyr Ala Leu Ala Asp Pro 
            20                  25                  30          


Ser Leu Lys Met Ala Asp Pro Asn Arg Phe Arg Gly Lys Asn Leu Pro 
        35                  40                  45              


Val Leu Asp Gln Leu Thr Asp Pro Pro Gly Val Lys Arg Val Tyr His 
    50                  55                  60                  


Ile Gln Pro Ser Leu Glu Asp Pro Phe Gln Pro Pro Ser Ile Pro Ile 
65                  70                  75                  80  


Thr Val Tyr Tyr Ala Val Leu Glu Arg Ala Cys Arg Ser Val Leu Leu 
                85                  90                  95      


His Ala Pro Ser Glu Ala Pro Gln Ile Val Arg Gly Ala Ser Asp Glu 
            100                 105                 110         


Ala Arg Lys His Thr Tyr Asn Leu Thr Ile Ala Trp Tyr Arg Met Gly 
        115                 120                 125             


Asp Asn Cys Ala Ile Pro Ile Thr Val Met Glu Tyr Thr Glu Cys Pro 
    130                 135                 140                 


Tyr Asn Lys Ser Leu Gly Val Cys Pro Ile Arg Thr Gln Pro Arg Trp 
145                 150                 155                 160 


Ser Tyr Tyr Asp Ser Phe Ser Ala Val Ser Glu Asp Asn Leu Gly Phe 
                165                 170                 175     


Leu Met His Ala Pro Ala Phe Glu Thr Ala Gly Thr Tyr Leu Arg Leu 
            180                 185                 190         


Val Lys Ile Asn Asp Trp Thr Glu Ile Thr Gln Phe Ile Leu Glu His 
        195                 200                 205             


Arg Ala Arg Ala Ser Cys Lys Tyr Ala Leu Pro Leu Arg Ile Pro Pro 
    210                 215                 220                 


Ala Ala Cys Leu Thr Ser Lys Ala Tyr Gln Gln Gly Val Thr Val Asp 
225                 230                 235                 240 


Ser Ile Gly Met Leu Pro Arg Phe Ile Pro Glu Asn Gln Arg Thr Val 
                245                 250                 255     


Ala Leu Tyr Ser Leu Lys Ile Ala Gly Trp His Gly Pro Lys Pro Pro 
            260                 265                 270         


Tyr Thr Ser Thr Leu Leu Pro Pro Glu Leu Ser Asp Thr Thr Asn Ala 
        275                 280                 285             


Thr Gln Pro Glu Leu Val Pro Glu Asp Pro Glu Asp Ser Ala Leu Leu 
    290                 295                 300                 


Glu Asp Pro Ala Gly Thr Val Ser Ser Gln Ile Pro Pro Asn Trp His 
305                 310                 315                 320 


Ile Pro Ser Ile Gln Asp Val Ala Pro His His Ala Pro Ala Ala Pro 
                325                 330                 335     


Ser Asn Pro Gly Leu Ile Ile Gly Ala Leu Ala Gly Ser Thr Leu Ala 
            340                 345                 350         


Val Leu Val Ile Gly Gly Ile Ala Phe Trp Val Arg Arg Arg Ala Gln 
        355                 360                 365             


Met Ala Pro Lys Arg Leu Arg Leu Pro His Ile Arg Asp Asp Asp Ala 
    370                 375                 380                 


Pro Pro Ser His Gln Pro Leu Phe Tyr 
385                 390             


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic protein of RING domain


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(43)
<223>  Xaa can be any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (46)..(47)
<223>  Xaa can be any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (49)..(50)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa can be any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa can be Asn, Cys or His

<220>
<221>  MISC_FEATURE
<222>  (53)..(54)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (56)..(59)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (60)..(103)
<223>  Xaa can be any amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (105)..(106)
<223>  Xaa can be any amino acid

<400>  5

Cys Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa His 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Cys 
            100                 105         


