                         SEQUENCE LISTING

<110>  AZURRX SAS
 
<120>  MOLECULE PROTEIQUE HYBRIDE APTE A INHIBER AU MOINS UN 
       ANTIBIOTIQUE ET COMPOSITION PHARMACEUTIQUE LA COMPORTANT

<130>  AZR1 PCT

<150>  FR1459935
<151>  2014-10-16

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  263
<212>  PRT
<213>  Escherichia coli

<400>  1

His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu 
            20                  25                  30          


Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys 
        35                  40                  45              


Val Leu Leu Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu 
    50                  55                  60                  


Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr 
65                  70                  75                  80  


Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu 
                85                  90                  95      


Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu 
            100                 105                 110         


Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His 
        115                 120                 125             


Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu 
    130                 135                 140                 


Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala 
145                 150                 155                 160 


Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu 
                165                 170                 175     


Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala 
            180                 185                 190         


Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp 
        195                 200                 205             


Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu 
    210                 215                 220                 


Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly 
225                 230                 235                 240 


Ser Gln Ala Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly 
                245                 250                 255     


Ala Ser Leu Ile Lys His Trp 
260


<210>  2
<211>  263
<212>  PRT
<213>  Escherichia coli

<400>  2

Gln Thr Ser Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser 
1               5                   10                  15      


Gly Gly Arg Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln 
            20                  25                  30          


Val Leu Tyr Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys 
        35                  40                  45              


Val Met Ala Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln 
    50                  55                  60                  


Leu Leu Asn Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr 
65                  70                  75                  80  


Asn Pro Ile Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu 
                85                  90                  95      


Leu Ser Ala Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys 
            100                 105                 110         


Leu Ile Ala Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg 
        115                 120                 125             


Ala Ile Gly Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu 
    130                 135                 140                 


Asn Thr Ala Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala 
145                 150                 155                 160 


Met Ala Gln Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu 
                165                 170                 175     


Thr Gln Arg Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly 
            180                 185                 190         


Ala Ala Ser Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp 
        195                 200                 205             


Lys Thr Gly Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile 
    210                 215                 220                 


Trp Pro Gln Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln 
225                 230                 235                 240 


Pro Gln Gln Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala 
                245                 250                 255     


Arg Ile Ile Ala Glu Gly Leu 
260


<210>  3
<211>  257
<212>  PRT
<213>  Staphylococcus aureus

<400>  3

Lys Glu Leu Asn Asp Leu Glu Lys Lys Tyr Asn Ala His Ile Gly Val 
1               5                   10                  15      


Tyr Ala Leu Asp Thr Lys Ser Gly Lys Glu Val Lys Phe Asn Ser Asp 
            20                  25                  30          


Lys Arg Phe Ala Tyr Ala Ser Thr Ser Lys Ala Ile Asn Ser Ala Ile 
        35                  40                  45              


Leu Leu Glu Gln Val Pro Tyr Asn Lys Leu Asn Lys Lys Val His Ile 
    50                  55                  60                  


Asn Lys Asp Asp Ile Val Ala Tyr Ser Pro Ile Leu Glu Lys Tyr Val 
65                  70                  75                  80  


Gly Lys Asp Ile Thr Leu Lys Ala Leu Ile Glu Ala Ser Met Thr Tyr 
                85                  90                  95      


Ser Asp Asn Thr Ala Asn Asn Lys Ile Ile Lys Glu Ile Gly Gly Ile 
            100                 105                 110         


Lys Lys Val Lys Gln Arg Leu Lys Glu Leu Gly Asp Lys Val Thr Asn 
        115                 120                 125             


Pro Val Arg Tyr Glu Ile Glu Leu Asn Tyr Tyr Ser Pro Lys Ser Lys 
    130                 135                 140                 


Lys Asp Thr Ser Thr Pro Ala Ala Phe Gly Lys Thr Leu Asn Lys Leu 
145                 150                 155                 160 


Ile Ala Asn Gly Lys Leu Ser Lys Glu Asn Lys Lys Phe Leu Leu Asp 
                165                 170                 175     


Leu Met Leu Asn Asn Lys Ser Gly Asp Thr Leu Ile Lys Asp Gly Val 
            180                 185                 190         


Pro Lys Asp Tyr Lys Val Ala Asp Lys Ser Gly Gln Ala Ile Thr Tyr 
        195                 200                 205             


Ala Ser Arg Asn Asp Val Ala Phe Val Tyr Pro Lys Gly Gln Ser Glu 
    210                 215                 220                 


Pro Ile Val Leu Val Ile Phe Thr Asn Lys Asp Asn Lys Ser Asp Lys 
225                 230                 235                 240 


Pro Asn Asp Lys Leu Ile Ser Glu Thr Ala Lys Ser Val Met Lys Glu 
                245                 250                 255     


Phe 
    


<210>  4
<211>  199
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Ser Asn Ala Lys Thr Lys Leu Gly Ile Thr Lys Tyr Ser Ile Val 
1               5                   10                  15      


Thr Asn Ser Asn Asp Ser Val Thr Leu Arg Leu Met Thr Glu His Asp 
            20                  25                  30          


Leu Ala Met Leu Tyr Glu Trp Leu Asn Arg Ser His Ile Val Glu Trp 
        35                  40                  45              


Trp Gly Gly Glu Glu Ala Arg Pro Thr Leu Ala Asp Val Gln Glu Gln 
    50                  55                  60                  


Tyr Leu Pro Ser Val Leu Ala Gln Glu Ser Val Thr Pro Tyr Ile Ala 
65                  70                  75                  80  


Met Leu Asn Gly Glu Pro Ile Gly Tyr Ala Gln Ser Tyr Val Ala Leu 
                85                  90                  95      


Gly Ser Gly Asp Gly Arg Trp Glu Glu Glu Thr Asp Pro Gly Val Arg 
            100                 105                 110         


Gly Ile Asp Gln Leu Leu Ala Asn Ala Ser Gln Leu Gly Lys Gly Leu 
        115                 120                 125             


Gly Thr Lys Leu Val Arg Ala Leu Val Glu Leu Leu Phe Asn Asp Pro 
    130                 135                 140                 


Glu Val Thr Lys Ile Gln Thr Asp Pro Ser Pro Ser Asn Leu Arg Ala 
145                 150                 155                 160 


Ile Arg Cys Tyr Glu Lys Ala Gly Phe Glu Arg Gln Gly Thr Val Thr 
                165                 170                 175     


Thr Pro Tyr Gly Pro Ala Val Tyr Met Val Gln Thr Arg Gln Ala Phe 
            180                 185                 190         


Glu Arg Thr Arg Ser Asp Ala 
195


<210>  5
<211>  419
<212>  PRT
<213>  Escherichia coli

<400>  5

Met Arg Phe Glu Glu Trp Val Lys Asp Lys His Ile Pro Phe Lys Leu 
1               5                   10                  15      


Asn His Pro Asp Asp Asn Tyr Asp Asp Phe Lys Pro Leu Arg Lys Ile 
            20                  25                  30          


Ile Gly Asp Thr Arg Val Val Ala Leu Gly Glu Asn Ser His Phe Ile 
        35                  40                  45              


Lys Glu Phe Phe Leu Leu Arg His Thr Leu Leu Arg Phe Phe Ile Glu 
    50                  55                  60                  


Asp Leu Gly Phe Thr Thr Phe Ala Phe Glu Phe Gly Phe Ala Glu Gly 
65                  70                  75                  80  


Gln Ile Ile Asn Asn Trp Ile His Gly Gln Gly Thr Asp Asp Glu Ile 
                85                  90                  95      


Gly Arg Phe Leu Lys His Phe Tyr Tyr Pro Glu Glu Leu Lys Thr Thr 
            100                 105                 110         


Phe Leu Trp Leu Arg Glu Tyr Asn Lys Ala Ala Lys Glu Lys Ile Thr 
        115                 120                 125             


Phe Leu Gly Ile Asp Ile Pro Arg Asn Gly Gly Ser Tyr Leu Pro Asn 
    130                 135                 140                 


Met Glu Ile Val His Asp Phe Phe Arg Thr Ala Asp Lys Glu Ala Leu 
145                 150                 155                 160 


His Ile Ile Asp Asp Ala Phe Asn Ile Ala Lys Lys Ile Asp Tyr Phe 
                165                 170                 175     


Ser Thr Ser Gln Ala Ala Leu Asn Leu His Glu Leu Thr Asp Ser Glu 
            180                 185                 190         


Lys Cys Arg Leu Thr Ser Gln Leu Ala Arg Val Lys Val Arg Leu Glu 
        195                 200                 205             


Ala Met Ala Pro Ile His Ile Glu Lys Tyr Gly Ile Asp Lys Tyr Glu 
    210                 215                 220                 


Thr Ile Leu His Tyr Ala Asn Gly Met Ile Tyr Leu Asp Tyr Asn Ile 
225                 230                 235                 240 


Gln Ala Met Ser Gly Phe Ile Ser Gly Gly Gly Met Gln Gly Asp Met 
                245                 250                 255     


Gly Ala Lys Asp Lys Tyr Met Ala Asp Ser Val Leu Trp His Leu Lys 
            260                 265                 270         


Asn Pro Gln Ser Glu Gln Lys Val Ile Val Val Ala His Asn Ala His 
        275                 280                 285             


Ile Gln Lys Thr Pro Ile Leu Tyr Asp Gly Phe Leu Ser Cys Leu Pro 
    290                 295                 300                 


Met Gly Gln Arg Leu Lys Asn Ala Ile Gly Asp Asp Tyr Met Ser Leu 
305                 310                 315                 320 


Gly Ile Thr Ser Tyr Ser Gly His Thr Ala Ala Leu Tyr Pro Glu Val 
                325                 330                 335     


Asp Thr Lys Tyr Gly Phe Arg Val Asp Asn Phe Gln Leu Gln Glu Pro 
            340                 345                 350         


Asn Glu Gly Ser Val Glu Lys Ala Ile Ser Gly Cys Gly Val Thr Asn 
        355                 360                 365             


Ser Phe Val Phe Phe Arg Asn Ile Pro Glu Asp Leu Gln Ser Ile Pro 
    370                 375                 380                 


Asn Met Ile Arg Phe Asp Ser Ile Tyr Met Lys Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala Phe Asp Gly Ile Phe Gln Ile Glu Lys Ser Ser Val Ser Glu Val 
                405                 410                 415     


Val Tyr Glu 
            


<210>  6
<211>  388
<212>  PRT
<213>  Bacteroides fragilis

<400>  6

Met Thr Met Arg Ile Asp Thr Asp Lys Gln Met Asn Leu Leu Ser Asp 
1               5                   10                  15      


Lys Asn Val Ala Ile Ile Gly Gly Gly Pro Val Gly Leu Thr Met Ala 
            20                  25                  30          


Lys Leu Leu Gln Gln Asn Gly Ile Asp Val Ser Val Tyr Glu Arg Asp 
        35                  40                  45              


Asn Asp Arg Glu Ala Arg Ile Phe Gly Gly Thr Leu Asp Leu His Lys 
    50                  55                  60                  


Gly Ser Gly Gln Glu Ala Met Lys Lys Ala Gly Leu Leu Gln Thr Tyr 
65                  70                  75                  80  


Tyr Asp Leu Ala Leu Pro Met Gly Val Asn Ile Ala Asp Lys Lys Gly 
                85                  90                  95      


Asn Ile Leu Ser Thr Lys Asn Val Lys Pro Glu Asn Arg Phe Asp Asn 
            100                 105                 110         


Pro Glu Ile Asn Arg Asn Asp Leu Arg Ala Ile Leu Leu Asn Ser Leu 
        115                 120                 125             


Glu Asn Asp Thr Val Ile Trp Asp Arg Lys Leu Val Met Leu Glu Pro 
    130                 135                 140                 


Gly Lys Lys Lys Trp Thr Leu Thr Phe Glu Asn Lys Pro Ser Glu Thr 
145                 150                 155                 160 


Ala Asp Leu Val Ile Leu Ala Asn Gly Gly Met Ser Lys Val Arg Lys 
                165                 170                 175     


Phe Val Thr Asp Thr Glu Val Glu Glu Thr Gly Thr Phe Asn Ile Gln 
            180                 185                 190         


Ala Asp Ile His Gln Pro Glu Ile Asn Cys Pro Gly Phe Phe Gln Leu 
        195                 200                 205             


Cys Asn Gly Asn Arg Leu Met Ala Ser His Gln Gly Asn Leu Leu Phe 
    210                 215                 220                 


Ala Asn Pro Asn Asn Asn Gly Ala Leu His Phe Gly Ile Ser Phe Lys 
225                 230                 235                 240 


Thr Pro Asp Glu Trp Lys Asn Gln Thr Gln Val Asp Phe Gln Asn Arg 
                245                 250                 255     


Asn Ser Val Val Asp Phe Leu Leu Lys Glu Phe Ser Asp Trp Asp Glu 
            260                 265                 270         


Arg Tyr Lys Glu Leu Ile His Thr Thr Leu Ser Phe Val Gly Leu Ala 
        275                 280                 285             


Thr Arg Ile Phe Pro Leu Glu Lys Pro Trp Lys Ser Lys Arg Pro Leu 
    290                 295                 300                 


Pro Ile Thr Met Ile Gly Asp Ala Ala His Leu Met Pro Pro Phe Ala 
305                 310                 315                 320 


Gly Gln Gly Val Asn Ser Gly Leu Val Asp Ala Leu Ile Leu Ser Asp 
                325                 330                 335     


Asn Leu Ala Asp Gly Lys Phe Asn Ser Ile Glu Glu Ala Val Lys Asn 
            340                 345                 350         


Tyr Glu Gln Gln Met Phe Met Tyr Gly Lys Glu Ala Gln Glu Glu Ser 
        355                 360                 365             


Thr Gln Asn Glu Ile Glu Met Phe Lys Pro Asp Phe Thr Phe Gln Gln 
    370                 375                 380                 


Leu Leu Asn Val 
385


<210>  7
<211>  267
<212>  PRT
<213>  Enterococcus faecium

<400>  7

Met Leu Lys Gln Lys Glu Leu Ile Ala Asn Val Lys Asn Leu Thr Glu 
1               5                   10                  15      


Ser Asp Glu Arg Ile Thr Ala Cys Met Met Tyr Gly Ser Phe Thr Lys 
            20                  25                  30          


Gly Glu Gly Asp Gln Tyr Ser Asp Ile Glu Phe Tyr Ile Phe Leu Lys 
        35                  40                  45              


His Ser Ile Thr Ser Asn Phe Asp Ser Ser Asn Trp Leu Phe Asp Val 
    50                  55                  60                  


Ala Pro Tyr Leu Met Leu Tyr Lys Asn Glu Tyr Gly Thr Glu Val Val 
65                  70                  75                  80  


Ile Phe Asp Asn Leu Ile Arg Gly Glu Phe His Phe Leu Ser Glu Lys 
                85                  90                  95      


Asp Met Asn Ile Ile Pro Ser Phe Lys Asp Ser Gly Tyr Ile Pro Asp 
            100                 105                 110         


Thr Lys Ala Met Leu Ile Tyr Asp Glu Thr Gly Gln Leu Glu Asn Tyr 
        115                 120                 125             


Leu Ser Glu Ile Ser Gly Ala Arg Pro Asn Arg Leu Thr Glu Glu Asn 
    130                 135                 140                 


Ala Asn Phe Leu Leu Cys Asn Phe Ser Asn Leu Trp Leu Met Gly Ile 
145                 150                 155                 160 


Asn Val Leu Lys Arg Gly Glu Tyr Ala Arg Ser Leu Glu Leu Leu Ser 
                165                 170                 175     


Gln Leu Gln Lys Asn Thr Leu Gln Leu Ile Arg Met Ala Glu Lys Asn 
            180                 185                 190         


Ala Asp Asn Trp Leu Asn Met Ser Lys Asn Leu Glu Lys Glu Ile Ser 
        195                 200                 205             


Leu Glu Asn Tyr Lys Lys Phe Ala Lys Thr Thr Ala Arg Leu Asp Lys 
    210                 215                 220                 


Val Glu Leu Phe Glu Ala Tyr Lys Asn Ser Leu Leu Leu Val Met Asp 
225                 230                 235                 240 


Leu Gln Ser His Leu Ile Glu Gln Tyr Asn Leu Lys Val Thr His Asp 
                245                 250                 255     


Ile Leu Glu Arg Leu Leu Asn Tyr Ile Ser Glu 
            260                 265         


<210>  8
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion 1 TEM36-6G-CTXM16

<400>  8

His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu 
            20                  25                  30          


Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys 
        35                  40                  45              


Val Leu Leu Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu 
    50                  55                  60                  


Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr 
65                  70                  75                  80  


Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu 
                85                  90                  95      


Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu 
            100                 105                 110         


Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His 
        115                 120                 125             


Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu 
    130                 135                 140                 


Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala 
145                 150                 155                 160 


Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu 
                165                 170                 175     


Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala 
            180                 185                 190         


Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp 
        195                 200                 205             


Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu 
    210                 215                 220                 


Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly 
225                 230                 235                 240 


Ser Gln Ala Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly 
                245                 250                 255     


Ala Ser Leu Ile Lys His Trp Gly Gly Gly Gly Gly Gly Gln Thr Ser 
            260                 265                 270         


Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser Gly Gly Arg 
        275                 280                 285             


Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln Val Leu Tyr 
    290                 295                 300                 


Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys Val Met Ala 
305                 310                 315                 320 


Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln Leu Leu Asn 
                325                 330                 335     


Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr Asn Pro Ile 
            340                 345                 350         


Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu Leu Ser Ala 
        355                 360                 365             


Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys Leu Ile Ala 
    370                 375                 380                 


Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg Ala Ile Gly 
385                 390                 395                 400 


Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu Asn Thr Ala 
                405                 410                 415     


Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala Met Ala Gln 
            420                 425                 430         


Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu Thr Gln Arg 
        435                 440                 445             


Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly Ala Ala Ser 
    450                 455                 460                 


Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp Lys Thr Gly 
465                 470                 475                 480 


Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile Trp Pro Gln 
                485                 490                 495     


Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln Pro Gln Gln 
            500                 505                 510         


Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala Arg Ile Ile 
        515                 520                 525             


Ala Glu Gly Leu 
530


<210>  9
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion 2 CTXM16-6G-TEM36

<400>  9

Gln Thr Ser Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser 
1               5                   10                  15      


Gly Gly Arg Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln 
            20                  25                  30          


Val Leu Tyr Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys 
        35                  40                  45              


Val Met Ala Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln 
    50                  55                  60                  


Leu Leu Asn Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr 
65                  70                  75                  80  


Asn Pro Ile Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu 
                85                  90                  95      


Leu Ser Ala Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys 
            100                 105                 110         


Leu Ile Ala Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg 
        115                 120                 125             


Ala Ile Gly Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu 
    130                 135                 140                 


Asn Thr Ala Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala 
145                 150                 155                 160 


Met Ala Gln Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu 
                165                 170                 175     


Thr Gln Arg Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly 
            180                 185                 190         


Ala Ala Ser Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp 
        195                 200                 205             


Lys Thr Gly Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile 
    210                 215                 220                 


Trp Pro Gln Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln 
225                 230                 235                 240 


Pro Gln Gln Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala 
                245                 250                 255     


Arg Ile Ile Ala Glu Gly Leu Gly Gly Gly Gly Gly Gly His Pro Glu 
            260                 265                 270         


Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly Ala Arg Val 
        275                 280                 285             


Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe 
    290                 295                 300                 


Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys Val Leu Leu 
305                 310                 315                 320 


Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu Gln Leu Gly 
                325                 330                 335     


Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr Ser Pro Val 
            340                 345                 350         


Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu Leu Cys Ser 
        355                 360                 365             


Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr 
    370                 375                 380                 


Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His Asn Met Gly 
385                 390                 395                 400 


Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala 
                405                 410                 415     


Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala Met Ala Thr 
            420                 425                 430         


Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg 
        435                 440                 445             


Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala Gly Pro Leu 
    450                 455                 460                 


Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp 
                485                 490                 495     


Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly Ser Gln Ala 
            500                 505                 510         


Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu 
        515                 520                 525             


Ile Lys His Trp 
530


<210>  10
<211>  537
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion 3 TEM36-G(EAAAK)2-CTXM16

<400>  10

His Pro Glu Thr Leu Val Lys Val Lys Asp Ala Glu Asp Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Gly Tyr Ile Glu Leu Asp Leu Asn Ser Gly Lys Ile Leu 
            20                  25                  30          


Glu Ser Phe Arg Pro Glu Glu Arg Phe Pro Met Val Ser Thr Phe Lys 
        35                  40                  45              


Val Leu Leu Cys Gly Ala Val Leu Ser Arg Val Asp Ala Gly Gln Glu 
    50                  55                  60                  


Gln Leu Gly Arg Arg Ile His Tyr Ser Gln Asn Asp Leu Val Glu Tyr 
65                  70                  75                  80  


Ser Pro Val Thr Glu Lys His Leu Thr Asp Gly Met Thr Val Arg Glu 
                85                  90                  95      


Leu Cys Ser Ala Ala Ile Thr Met Ser Asp Asn Thr Ala Ala Asn Leu 
            100                 105                 110         


Leu Leu Thr Thr Ile Gly Gly Pro Lys Glu Leu Thr Ala Phe Leu His 
        115                 120                 125             


Asn Met Gly Asp His Val Thr Arg Leu Asp Arg Trp Glu Pro Glu Leu 
    130                 135                 140                 


Asn Glu Ala Ile Pro Asn Asp Glu Arg Asp Thr Thr Met Pro Ala Ala 
145                 150                 155                 160 


Met Ala Thr Thr Leu Arg Lys Leu Leu Thr Gly Glu Leu Leu Thr Leu 
                165                 170                 175     


Ala Ser Arg Gln Gln Leu Ile Asp Trp Met Glu Ala Asp Lys Val Ala 
            180                 185                 190         


Gly Pro Leu Leu Arg Ser Ala Leu Pro Ala Gly Trp Phe Ile Ala Asp 
        195                 200                 205             


Lys Ser Gly Ala Gly Glu Arg Gly Ser Arg Gly Ile Ile Ala Ala Leu 
    210                 215                 220                 


Gly Pro Asp Gly Lys Pro Ser Arg Ile Val Val Ile Tyr Thr Thr Gly 
225                 230                 235                 240 


Ser Gln Ala Thr Met Asp Glu Arg Asp Arg Gln Ile Ala Glu Ile Gly 
                245                 250                 255     


Ala Ser Leu Ile Lys His Trp Gly Glu Ala Ala Ala Lys Glu Ala Ala 
            260                 265                 270         


Ala Lys Gln Thr Ser Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys 
        275                 280                 285             


Ser Ser Gly Gly Arg Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn 
    290                 295                 300                 


Thr Gln Val Leu Tyr Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr 
305                 310                 315                 320 


Ser Lys Val Met Ala Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln 
                325                 330                 335     


Lys Gln Leu Leu Asn Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val 
            340                 345                 350         


Asn Tyr Asn Pro Ile Ala Glu Lys His Val Asn Gly Thr Met Thr Leu 
        355                 360                 365             


Ala Glu Leu Ser Ala Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met 
    370                 375                 380                 


Asn Lys Leu Ile Ala Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe 
385                 390                 395                 400 


Ala Arg Ala Ile Gly Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro 
                405                 410                 415     


Thr Leu Asn Thr Ala Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro 
            420                 425                 430         


Arg Ala Met Ala Gln Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu 
        435                 440                 445             


Gly Glu Thr Gln Arg Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr 
    450                 455                 460                 


Thr Gly Ala Ala Ser Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala 
465                 470                 475                 480 


Gly Asp Lys Thr Gly Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala 
                485                 490                 495     


Val Ile Trp Pro Gln Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe 
            500                 505                 510         


Thr Gln Pro Gln Gln Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser 
        515                 520                 525             


Ala Ala Arg Ile Ile Ala Glu Gly Leu 
    530                 535         


<210>  11
<211>  4158
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vecteur et sequence clonnee TEM36

<400>  11
acattgcctg aattggtttg ccccggaaga ttggggaaac ttggatctga ttaccttagc       60

tgcaggtacc actgagcgtc agaccccgta gaaaagatca aaggatcttc ttgagatcct      120

ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt      180

tgtttgtcgg atcaagagct accaactctt tttccgaagg taactggctt cagcagagcg      240

cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt caagaactct      300

gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc tgccagtggc      360

gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa ggcgcagcgg      420

tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac ctacaccgaa      480

ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg gagaaaggcg      540

gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga gcttccaggg      600

ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact tgagcgtcga      660

tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa acgccagcaa cgcggccttt      720

ttacggttcc tggccttttg ctggcctttt gctcacatgt tctttcctgc ggtacccaga      780

tccaattccc gctttgactg cctgaaatct ccatcgccta caatgatgac atttggattt      840

ggttgactca tgttggtatt gtgaaataga cgcagatcgg gaacactgaa aaatacacag      900

ttattattca tttaaatttt ttgtagaaat gtcttggtgt cctcgtccaa tcaggtagcc      960

atctctgaaa tatctggctc cgttgcaact ccgaacgacc tgctggcaac gtaaaattct     1020

ccggggtaaa acttaaatgt ggagtaatgg aaccagaaac gtctcttccc ttctctctcc     1080

ttccaccgcc cgttaccgtc cctaggaaat tttactctgc tggagagctt cttctacggc     1140

ccccttgcag caatgctctt cccagcatta cgttgcgggt aaaacggagg tcgtgtaccc     1200

gacctagcag cccagggatg gaaaagtccc ggccgtcgct ggcaataata gcgggcggac     1260

gcatgtcatg agattattgg aaaccaccag aatcgaatat aaaaggcgaa cacctttccc     1320

aattttggtt tctcctgacc caaagacttt aaatttaatt tatttgtccc tatttcaatc     1380

aattgaacaa ctatcaaaac acagaattcc gaaacgatga gattcccatc tattttcacc     1440

gctgtcttgt tcgctgcctc ctctgcattg gctgcccctg ttaacactac cactgaagac     1500

gagactgctc aaattccagc tgaagcagtt atcggttact ctgaccttga gggtgatttc     1560

gacgtcgctg ttttgccttt ctctaactcc actaacaacg gtttgttgtt cattaacacc     1620

actatcgctt ccattgctgc taaggaagag ggtgtctctc tcgagaaaag agaggccgaa     1680

gctcaccctg agacacttgt caaggttaag gatgccgaag atcaactagg agcaagggtt     1740

ggttacattg aactggactt gaatagtggt aagattttag agagcttcag acctgaggag     1800

cgattcccaa tggttagcac ctttaaggta ctcctatgcg gagcagtgtt gtcaagagtc     1860

gatgctggtc aagagcagtt aggaaggaga atccattatt cacagaacga cttggttgaa     1920

tattccccag tgactgagaa acacttgaca gatggaatga cagttcgtga gttgtgttct     1980

gctgctatca ctatgtctga taatacagct gcaaatctgc tgctgacgac aatcggtggt     2040

cccaaagagt tgaccgcttt tctgcataac atgggcgatc acgtaacaag acttgaccgt     2100

tgggagcctg aacttaacga agccatcccc aatgacgaaa gagatactac tatgccagct     2160

gcaatggcta ccactctgcg taagttgctt actggtgaat tgttgacgtt agcttctagg     2220

caacaattaa tcgactggat ggaagctgat aaagttgctg gcccattgtt gagaagtgct     2280

ttgccggcag gatggttcat tgcagacaaa tcgggagccg gtgaaagagg ttcaagaggt     2340

attatagctg cattgggtcc tgacggtaaa ccatccagaa ttgtggtcat ctacactact     2400

ggttcccagg ctacaatgga cgagcgtgat agacaaattg ccgaaatagg agcatcccta     2460

atcaaacatt ggtgaggggc ggccgctcaa gaggatgtca gaatgccatt tgcctgagag     2520

atgcaggctt catttttgat acttttttat ttgtaaccta tatagtatag gatttttttt     2580

gtcattttgt ttcttctcgt acgagcttgc tcctgatcag cctatctcgc agcagatgaa     2640

tatcttgtgg taggggtttg ggaaaatcat tcgagtttga tgtttttctt ggtatttccc     2700

actcctcttc agagtacaga agattaagtg aaaccttcgt ttgtgcggat ccttcagtaa     2760

tgtcttgttt cttttgttgc agtggtgagc cattttgact tcgtgaaagt ttctttagaa     2820

tagttgtttc cagaggccaa acattccacc cgtagtaaag tgcaagcgta ggaagaccaa     2880

gactggcata aatcaggtat aagtgtcgag cactggcagg tgatcttctg aaagtttcta     2940

ctagcagata agatccagta gtcatgcata tggcaacaat gtaccgtgtg gatctaagaa     3000

cgcgtcctac taaccttcgc attcgttggt ccagtttgtt gttatcgatc aacgtgacaa     3060

ggttgtcgat tccgcgtaag catgcatacc caaggacgcc tgttgcaatt ccaagtgagc     3120

cagttccaac aatctttgta atattagagc acttcattgt gttgcgcttg aaagtaaaat     3180

gcgaacaaat taagagataa tctcgaaacc gcgacttcaa acgccaatat gatgtgcggc     3240

acacaataag cgttcatatc cgctgggtga ctttctcgct ttaaaaaatt atccgaaaaa     3300

attttctaga gtgttgttac tttatacttc cggctcgtat aatacgacaa ggtgtaagga     3360

ggactaaacc atggctaaac tcacctctgc tgttccagtc ctgactgctc gtgatgttgc     3420

tggtgctgtt gagttctgga ctgatagact cggtttctcc cgtgacttcg tagaggacga     3480

ctttgccggt gttgtacgtg acgacgttac cctgttcatc tccgcagttc aggaccaggt     3540

tgtgccagac aacactctgg catgggtatg ggttcgtggt ctggacgaac tgtacgctga     3600

gtggtctgag gtcgtgtcta ccaacttccg tgatgcatct ggtccagcta tgaccgagat     3660

cggtgaacag ccctggggtc gtgagtttgc actgcgtgat ccagctggta actgcgtgca     3720

tttcgtcgca gaagagcagg actaacaatt gacaccttac gattatttag agagtattta     3780

ttagttttat tgtatgtata cggatgtttt attatctatt tatgccctta tattctgtaa     3840

ctatccaaaa gtcctatctt atcaagccag caatctatgt ccgcgaacgt caactaaaaa     3900

taagcttttt atgctcttct ctcttttttt cccttcggta taattatacc ttgcatccac     3960

agattctcct gccaaatttt gcataatcct ttacaacatg gctatatggg agcacttagc     4020

gccctccaaa acccatattg cctacgcatg tataggtgtt ttttccacaa tattttctct     4080

gtgctctctt tttattaaag agaagctcta tatcggagaa gcttctgtgg ccgttatatt     4140

cggccttatc gtgggacc                                                   4158


<210>  12
<211>  900
<212>  DNA
<213>  Escherichia coli

<400>  12
actatcgctt ccattgctgc taaggaagag ggtgtctctc tcgagaaaag agaggccgaa       60

gctcagacgt cagccgtgca gcaaaagcta gctgcgctag aaaagtcgag cggcggtcgg      120

cttggtgttg cattgattga caccgccgac aacacccagg tattgtatcg tggggatgaa      180

cgcttcccga tgtgctctac atctaaagtt atggcggccg ctgcagtgct gaaacaatct      240

gaaacgcaga agcaattgct gaatcagccc gttgagatta agccggctga tctggtgaat      300

tacaatccga ttgccgaaaa acacgtgaac ggtaccatga cgctggctga actgagtgct      360

gcagcgcttc aatatagcga taacacggcc atgaataagc tgatcgccca gttaggcggt      420

ccgggaggag tgaccgcctt cgcgcgtgcc ataggtgatg aaactttccg tctggatcgc      480

acggaaccga cactgaacac agcgatcccg ggtgatccac gtgataccac cacgccgcgc      540

gcaatggcac agaccctgcg ccaactgacg ctcggccatg cgctggggga gacacaacgt      600

gcgcagctgg ttacttggct gaaagggaat acaactgggg ctgcgtcgat tcgtgctgga      660

ctgccgacaa gttggactgc cggcgataaa actgggtcag gtggatatgg cactaccaat      720

gatatcgcag tgatatggcc gcagggtaga gcgcctcttg ttttggttac ctacttcacg      780

caaccccagc agaacgcgga gtcacgtcgt gacgtgcttg catcagccgc tcggatcata      840

gctgaaggtt tgtaaaagcg gccgccgctc aagaggatgt cagaatgcca tttgcctgag      900


<210>  13
<211>  1680
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion 1 TEM36-G6-CTXM16

<400>  13
actatcgctt ccattgctgc taaggaagag ggtgtctctc tcgagaaaag agaggccgaa       60

gctcaccctg agacacttgt caaggttaag gatgccgaag atcaactagg agcaagggtt      120

ggttacattg aactggactt gaatagtggt aagattttag agagcttcag acctgaggag      180

cgattcccaa tggttagcac ctttaaggta ctcctatgcg gagcagtgtt gtcaagagtc      240

gatgctggtc aagagcagtt aggaaggaga atccattatt cacagaacga cttggttgaa      300

tattccccag tgactgagaa acacttgaca gatggaatga cagttcgtga gttgtgttct      360

gctgctatca ctatgtctga taatacagct gcaaatctgc tgctgacgac aatcggtggt      420

cccaaagagt tgaccgcttt tctgcataac atgggcgatc acgtaacaag acttgaccgt      480

tgggagcctg aacttaacga agccatcccc aatgacgaaa gagatactac tatgccagct      540

gcaatggcta ccactctgcg taagttgctt actggtgaat tgttgacgtt agcttctagg      600

caacaattaa tcgactggat ggaagctgat aaagttgctg gcccattgtt gagaagtgct      660

ttgccggcag gatggttcat tgcagacaaa tcgggagccg gtgaaagagg ttcaagaggt      720

attatagctg cattgggtcc tgacggtaaa ccatccagaa ttgtggtcat ctacactact      780

ggttcccagg ctacaatgga cgagcgtgat agacaaattg ccgaaatagg agcatcccta      840

atcaaacatt ggggaggagg tggaggtgga cagacgtcag ccgtgcagca aaagctagct      900

gcgctagaaa agtcgagcgg cggtcggctt ggtgttgcat tgattgacac cgccgacaac      960

acccaggtat tgtatcgtgg ggatgaacgc ttcccgatgt gctctacatc taaagttatg     1020

gcggccgctg cagtgctgaa acaatctgaa acgcagaagc aattgctgaa tcagcccgtt     1080

gagattaagc cggctgatct ggtgaattac aatccgattg ccgaaaaaca cgtgaacggt     1140

accatgacgc tggctgaact gagtgctgca gcgcttcaat atagcgataa cacggccatg     1200

aataagctga tcgcccagtt aggcggtccg ggaggagtga ccgccttcgc gcgtgccata     1260

ggtgatgaaa ctttccgtct ggatcgcacg gaaccgacac tgaacacagc gatcccgggt     1320

gatccacgtg ataccaccac gccgcgcgca atggcacaga ccctgcgcca actgacgctc     1380

ggccatgcgc tgggggagac acaacgtgcg cagctggtta cttggctgaa agggaataca     1440

actggggctg cgtcgattcg tgctggactg ccgacaagtt ggactgccgg cgataaaact     1500

gggtcaggtg gatatggcac taccaatgat atcgcagtga tatggccgca gggtagagcg     1560

cctcttgttt tggttaccta cttcacgcaa ccccagcaga acgcggagtc acgtcgtgac     1620

gtgcttgcat cagccgctcg gatcatagct gaaggtttgt aaaagcggcc gctcaagaga     1680


<210>  14
<211>  1634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion 2 CTXM16-G6-TEM36

<400>  14
ctcgagaaaa gagaggccga agctcagacg tcagccgtgc agcaaaagct agctgcgcta       60

gaaaagtcga gcggcggtcg gcttggtgtt gcattgattg acaccgccga caacacccag      120

gtattgtatc gtggggatga acgcttcccg atgtgctcta catctaaagt tatggcggcc      180

gctgcagtgc tgaaacaatc tgaaacgcag aagcaattgc tgaatcagcc cgttgagatt      240

aagccggctg atctggtgaa ttacaatccg attgccgaaa aacacgtgaa cggtaccatg      300

acgctggctg aactgagtgc tgcagcgctt caatatagcg ataacacggc catgaataag      360

ctgatcgccc agttaggcgg tccgggagga gtgaccgcct tcgcgcgtgc cataggtgat      420

gaaactttcc gtctggatcg cacggaaccg acactgaaca cagcgatccc gggtgatcca      480

cgtgatacca ccacgccgcg cgcaatggca cagaccctgc gccaactgac gctcggccat      540

gcgctggggg agacacaacg tgcgcagctg gttacttggc tgaaagggaa tacaactggg      600

gctgcgtcga ttcgtgctgg actgccgaca agttggactg ccggcgataa aactgggtca      660

ggtggatatg gcactaccaa tgatatcgca gtgatatggc cgcagggtag agcgcctctt      720

gttttggtta cctacttcac gcaaccccag cagaacgcgg agtcacgtcg tgacgtgctt      780

gcatcagccg ctcggatcat agctgaaggt ttgggaggag gaggaggagg acaccctgag      840

acacttgtca aggttaagga tgccgaagat caactaggag caagggttgg ttacattgaa      900

ctggacttga atagtggtaa gattttagag agcttcagac ctgaggagcg attcccaatg      960

gttagcacct ttaaggtact cctatgcgga gcagtgttgt caagagtcga tgctggtcaa     1020

gagcagttag gaaggagaat ccattattca cagaacgact tggttgaata ttccccagtg     1080

actgagaaac acttgacaga tggaatgaca gttcgtgagt tgtgttctgc tgctatcact     1140

atgtctgata atacagctgc aaatctgctg ctgacgacaa tcggtggtcc caaagagttg     1200

accgcttttc tgcataacat gggcgatcac gtaacaagac ttgaccgttg ggagcctgaa     1260

cttaacgaag ccatccccaa tgacgaaaga gatactacta tgccagctgc aatggctacc     1320

actctgcgta agttgcttac tggtgaattg ttgacgttag cttctaggca acaattaatc     1380

gactggatgg aagctgataa agttgctggc ccattgttga gaagtgcttt gccggcagga     1440

tggttcattg cagacaaatc gggagccggt gaaagaggtt caagaggtat tatagctgca     1500

ttgggtcctg acggtaaacc atccagaatt gtggtcatct acactactgg ttcccaggct     1560

acaatggacg agcgtgatag acaaattgcc gaaataggag catccctaat caaacattgg     1620

tgaggggcgg ccgc                                                       1634


<210>  15
<211>  1648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion 3 TEM36-G(EAAAK)2-CTXM16

<400>  15
ctcgagaaaa gagaggccga agctcaccct gagacacttg tcaaggttaa ggatgccgaa       60

gatcaactag gagcaagggt tggttacatt gaactggact tgaatagtgg taagatttta      120

gagagcttca gacctgagga gcgattccca atggttagca cctttaaggt actcctatgc      180

ggagcagtgt tgtcaagagt cgatgctggt caagagcagt taggaaggag aatccattat      240

tcacagaacg acttggttga atattcccca gtgactgaga aacacttgac agatggaatg      300

acagttcgtg agttgtgttc tgctgctatc actatgtctg ataatacagc tgcaaatctg      360

ctgctgacga caatcggtgg tcccaaagag ttgaccgctt ttctgcataa catgggcgat      420

cacgtaacaa gacttgaccg ttgggagcct gaacttaacg aagccatccc caatgacgaa      480

agagatacta ctatgccagc tgcaatggct accactctgc gtaagttgct tactggtgaa      540

ttgttgacgt tagcttctag gcaacaatta atcgactgga tggaagctga taaagttgct      600

ggcccattgt tgagaagtgc tttgccggca ggatggttca ttgcagacaa atcgggagcc      660

ggtgaaagag gttcaagagg tattatagct gcattgggtc ctgacggtaa accatccaga      720

attgtggtca tctacactac tggttcccag gctacaatgg acgagcgtga tagacaaatt      780

gccgaaatag gagcatccct aatcaaacat tggggagagg cggccgctaa agaggcagca      840

gcaaaacaga cgtcagccgt gcagcaaaag ctagctgcgc tagaaaagtc gagcggcggt      900

cggcttggtg ttgcattgat tgacaccgcc gacaacaccc aggtattgta tcgtggggat      960

gaacgcttcc cgatgtgctc tacatctaaa gttatggcgg ccgctgcagt gctgaaacaa     1020

tctgaaacgc agaagcaatt gctgaatcag cccgttgaga ttaagccggc tgatctggtg     1080

aattacaatc cgattgccga aaaacacgtg aacggtacca tgacgctggc tgaactgagt     1140

gctgcagcgc ttcaatatag cgataacacg gccatgaata agctgatcgc ccagttaggc     1200

ggtccgggag gagtgaccgc cttcgcgcgt gccataggtg atgaaacttt ccgtctggat     1260

cgcacggaac cgacactgaa cacagcgatc ccgggtgatc cacgtgatac caccacgccg     1320

cgcgcaatgg cacagaccct gcgccaactg acgctcggcc atgcgctggg ggagacacaa     1380

cgtgcgcagc tggttacttg gctgaaaggg aatacaactg gggctgcgtc gattcgtgct     1440

ggactgccga caagttggac tgccggcgat aaaactgggt caggtggata tggcactacc     1500

aatgatatcg cagtgatatg gccgcagggt agagcgcctc ttgttttggt tacctacttc     1560

acgcaacccc agcagaacgc ggagtcacgt cgtgacgtgc ttgcatcagc cgctcggatc     1620

atagctgaag gtttgtaaaa gcggccgc                                        1648


<210>  16
<211>  870
<212>  DNA
<213>  Escherichia coli

<400>  16
catatgagca ttcagcattt tcgcgtggcc ctgatcccgt ttttcgcggc cttttgcctg       60

ccggttttcg cacagacgtc agccgtgcag caaaagctag ctgcgctaga aaagtcgagc      120

ggcggtcggc ttggtgttgc attgattgac accgccgaca acacccaggt attgtatcgt      180

ggggatgaac gcttcccgat gtgctctaca tctaaagtta tggcggccgc tgcagtgctg      240

aaacaatctg aaacgcagaa gcaattgctg aatcagcccg ttgagattaa gccggctgat      300

ctggtgaatt acaatccgat tgccgaaaaa cacgtgaacg gtaccatgac gctggctgaa      360

ctgagtgctg cagcgcttca atatagcgat aacacggcca tgaataagct gatcgcccag      420

ttaggcggtc cgggaggagt gaccgccttc gcgcgtgcca taggtgatga aactttccgt      480

ctggatcgca cggaaccgac actgaacaca gcgatcccgg gtgatccacg tgataccacc      540

acgccgcgcg caatggcaca gaccctgcgc caactgacgc tcggccatgc gctgggggag      600

acacaacgtg cgcagctggt tacttggctg aaagggaata caactggggc tgcgtcgatt      660

cgtgctggac tgccgacaag ttggactgcc ggcgataaaa ctgggtcagg tggatatggc      720

actaccaatg atatcgcagt gatatggccg cagggtagag cgcctcttgt tttggttacc      780

tacttcacgc aaccccagca gaacgcggag tcacgtcgtg acgtgcttgc atcagccgct      840

cggatcatag ctgaaggttt gtaaaagctt                                       870


<210>  17
<211>  627
<212>  DNA
<213>  Escherichia coli

<400>  17
catatgagca acgctaagac gaaactgggt attaccaagt acagcatcgt gacgaatagc       60

aacgattccg tgacgctgcg tctgatgacc gaacacgact tggcaatgct gtacgagtgg      120

ctgaatcgca gccatatcgt tgagtggtgg ggtggtgaag aagcccgtcc gaccctggcc      180

gacgttcaag agcagtatct gccttctgtg ttggcgcaag aaagcgtgac cccgtatatt      240

gcaatgctga atggcgagcc gatcggttac gcgcaatcgt acgtggcact gggcagcggt      300

gatggtcgtt gggaagaaga gactgatccg ggcgttcgtg gtatcgacca gctgctggcc      360

aacgcgtccc agctcggtaa aggcttaggt accaaactgg tccgtgcatt ggttgagctg      420

ctgttcaacg atccggaagt caccaagatt caaaccgacc cgagcccgag caatctgcgt      480

gcgattcgct gctatgagaa agcgggcttc gagcgccagg gcactgtcac cacgccgtat      540

ggtccagctg tttacatggt ccagacgcgc caggcgtttg agcgtacccg tagcgacgcg      600

caccaccatc atcaccacta aaagctt                                          627


<210>  18
<211>  1416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion 5 AAC-H6-CTXM16

<400>  18
catatgagca acgctaagac gaaactgggt attaccaagt acagcatcgt gacgaatagc       60

aacgattccg tgacgctgcg tctgatgacc gaacacgact tggcaatgct gtacgagtgg      120

ctgaatcgca gccatatcgt tgagtggtgg ggtggtgaag aagcccgtcc gaccctggcc      180

gacgttcaag agcagtatct gccttctgtg ttggcgcaag aaagcgtgac cccgtatatt      240

gcaatgctga atggcgagcc gatcggttac gcgcaatcgt acgtggcact gggcagcggt      300

gatggtcgtt gggaagaaga gactgatccg ggcgttcgtg gtatcgacca gctgctggcc      360

aacgcgtccc agctcggtaa aggcttaggt accaaactgg tccgtgcatt ggttgagctg      420

ctgttcaacg atccggaagt caccaagatt caaaccgacc cgagcccgag caatctgcgt      480

gcgattcgct gctatgagaa agcgggcttc gagcgccagg gcactgtcac cacgccgtat      540

ggtccagctg tttacatggt ccagacgcgc caggcgtttg agcgtacccg tagcgacgcg      600

caccaccatc atcaccacca gacgtcagcc gtgcagcaaa agctagctgc gctagaaaag      660

tcgagcggcg gtcggcttgg tgttgcattg attgacaccg ccgacaacac ccaggtattg      720

tatcgtgggg atgaacgctt cccgatgtgc tctacatcta aagttatggc ggccgctgca      780

gtgctgaaac aatctgaaac gcagaagcaa ttgctgaatc agcccgttga gattaagccg      840

gctgatctgg tgaattacaa tccgattgcc gaaaaacacg tgaacggtac catgacgctg      900

gctgaactga gtgctgcagc gcttcaatat agcgataaca cggccatgaa taagctgatc      960

gcccagttag gcggtccggg aggagtgacc gccttcgcgc gtgccatagg tgatgaaact     1020

ttccgtctgg atcgcacgga accgacactg aacacagcga tcccgggtga tccacgtgat     1080

accaccacgc cgcgcgcaat ggcacagacc ctgcgccaac tgacgctcgg ccatgcgctg     1140

ggggagacac aacgtgcgca gctggttact tggctgaaag ggaatacaac tggggctgcg     1200

tcgattcgtg ctggactgcc gacaagttgg actgccggcg ataaaactgg gtcaggtgga     1260

tatggcacta ccaatgatat cgcagtgata tggccgcagg gtagagcgcc tcttgttttg     1320

gttacctact tcacgcaacc ccagcagaac gcggagtcac gtcgtgacgt gcttgcatca     1380

gccgctcgga tcatagctga aggtttgtaa aagctt                               1416


<210>  19
<211>  1287
<212>  DNA
<213>  Escherichia coli

<400>  19
catatgcgtt ttgaagagtg ggtcaaggac aagcacattc cgtttaagtt aaaccacccg       60

gatgacaatt acgacgactt caaaccgctg cgtaagatta ttggtgacac gcgcgtcgtg      120

gcgctgggtg agaatagcca ctttatcaaa gaattcttct tgctgcgcca cacgctgctg      180

cgtttcttta ttgaggacct gggcttcacc acgttcgcct ttgagttcgg cttcgcagag      240

ggtcagatca tcaacaattg gatccatggc caaggtaccg atgatgagat tggtcgtttc      300

ctgaaacact tctattaccc ggaagaactg aaaaccacct ttttgtggct gcgtgagtac      360

aataaagccg cgaaggaaaa gatcacgttt ctgggtattg acatcccgcg taacggtggc      420

agctatctgc cgaacatgga aatcgttcat gactttttcc gtaccgctga caaagaagcg      480

ctgcacatta ttgacgacgc gtttaacatc gcgaaaaaga tcgattactt tagcaccagc      540

caagcagcgc tgaatttgca tgagctgacg gacagcgaga aatgccgcct cacttcccag      600

ctggcacgtg tcaaggttcg cctggaagca atggcgccga tccacatcga gaagtatggc      660

attgacaagt acgaaacgat cctgcactat gcaaacggca tgatttatct ggattacaat      720

attcaggcca tgagcggttt catttccggt ggcggcatgc agggtgacat gggtgcgaaa      780

gataagtaca tggccgattc tgtcctgtgg cacctgaaga accctcagag cgagcagaaa      840

gttattgtgg tggctcataa tgcacatatt cagaaaaccc cgattttgta cgacggtttc      900

ctgagctgcc tgccgatggg tcaacgtctg aagaacgcga tcggtgatga ctacatgtct      960

ttgggcatca cctcgtatag cggtcatact gcggcactgt atccggaagt tgataccaaa     1020

tacggtttcc gcgtggataa ctttcaactg caagagccga acgagggtag cgtggagaaa     1080

gctattagcg gttgtggcgt taccaattcc ttcgtgttct ttcgtaatat cccggaagat     1140

ctgcagagca ttccaaacat gatccgcttc gatagcattt acatgaaagc ggagcttgag     1200

aaagcgtttg atggcatctt ccaaatcgaa aagagcagcg tcagcgaagt ggtttatgag     1260

caccaccatc accatcacta aaagctt                                         1287


<210>  20
<211>  2076
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  fusion 6 EreB-H6-TEM36

<400>  20
catatgcgtt ttgaagagtg ggtcaaggac aagcacattc cgtttaagtt aaaccacccg       60

gatgacaatt acgacgactt caaaccgctg cgtaagatta ttggtgacac gcgcgtcgtg      120

gcgctgggtg agaatagcca ctttatcaaa gaattcttct tgctgcgcca cacgctgctg      180

cgtttcttta ttgaggacct gggcttcacc acgttcgcct ttgagttcgg cttcgcagag      240

ggtcagatca tcaacaattg gatccatggc caaggtaccg atgatgagat tggtcgtttc      300

ctgaaacact tctattaccc ggaagaactg aaaaccacct ttttgtggct gcgtgagtac      360

aataaagccg cgaaggaaaa gatcacgttt ctgggtattg acatcccgcg taacggtggc      420

agctatctgc cgaacatgga aatcgttcat gactttttcc gtaccgctga caaagaagcg      480

ctgcacatta ttgacgacgc gtttaacatc gcgaaaaaga tcgattactt tagcaccagc      540

caagcagcgc tgaatttgca tgagctgacg gacagcgaga aatgccgcct cacttcccag      600

ctggcacgtg tcaaggttcg cctggaagca atggcgccga tccacatcga gaagtatggc      660

attgacaagt acgaaacgat cctgcactat gcaaacggca tgatttatct ggattacaat      720

attcaggcca tgagcggttt catttccggt ggcggcatgc agggtgacat gggtgcgaaa      780

gataagtaca tggccgattc tgtcctgtgg cacctgaaga accctcagag cgagcagaaa      840

gttattgtgg tggctcataa tgcacatatt cagaaaaccc cgattttgta cgacggtttc      900

ctgagctgcc tgccgatggg tcaacgtctg aagaacgcga tcggtgatga ctacatgtct      960

ttgggcatca cctcgtatag cggtcatact gcggcactgt atccggaagt tgataccaaa     1020

tacggtttcc gcgtggataa ctttcaactg caagaaccaa acgagggtag cgtggagaaa     1080

gctattagcg gttgtggcgt taccaattcc ttcgtgttct ttcgtaatat cccggaagat     1140

ctgcagagca ttccaaacat gatccgcttc gatagcattt acatgaaagc ggagcttgag     1200

aaagcgtttg atggcatctt ccaaatcgaa aagagcagcg tcagcgaagt ggtttatgag     1260

caccaccatc accatcacca cccggaaacc ctggtgaaag ttaaagatgc ggaagatcag     1320

ctgggcgccc gtgtgggtta tattgaactg gatctgaaca gcggcaaaat cctggaatct     1380

tttcgtccgg aagaacgctt cccgatggtg tctaccttta aagttctgct gtgcggtgca     1440

gtgctgagtc gcgttgatgc gggccaggaa cagctgggtc gtcgcattca ttatagccag     1500

aatgatctgg tggaatactc tccggttacc gaaaaacacc tgaccgatgg catgacggtg     1560

cgtgaactgt gtagtgcagc gattaccatg agcgataaca cggccgcaaa tctgctgctg     1620

accacgatcg gcggtccgaa agaactgacc gccttcctgc ataacatggg tgatcacgtt     1680

acgcgtctgg atcgctggga accggaactg aacgaagcga tcccgaatga tgaacgtgat     1740

accaccatgc cggccgcaat ggcaaccacc ctgcgcaaac tgctgaccgg cgaactgctg     1800

acgctggcaa gccgtcagca gctgattgat tggatggaag cggataaagt tgcgggtccg     1860

ctgctgcgtt ctgcactgcc ggcaggttgg tttatcgccg ataaatctgg cgcaggtgaa     1920

cgtggcagtc gcggtattat cgcagcgctg ggcccggatg gtaaaccgag tcgtattgtg     1980

gttatctaca ccacgggcag ccaggcgacc atggatgaac gtgatcgcca gattgcagaa     2040

atcggtgcga gcctgattaa acattggtaa aagctt                               2076


<210>  21
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion 5 AAC-H6-CTXM16

<400>  21

Met Ser Asn Ala Lys Thr Lys Leu Gly Ile Thr Lys Tyr Ser Ile Val 
1               5                   10                  15      


Thr Asn Ser Asn Asp Ser Val Thr Leu Arg Leu Met Thr Glu His Asp 
            20                  25                  30          


Leu Ala Met Leu Tyr Glu Trp Leu Asn Arg Ser His Ile Val Glu Trp 
        35                  40                  45              


Trp Gly Gly Glu Glu Ala Arg Pro Thr Leu Ala Asp Val Gln Glu Gln 
    50                  55                  60                  


Tyr Leu Pro Ser Val Leu Ala Gln Glu Ser Val Thr Pro Tyr Ile Ala 
65                  70                  75                  80  


Met Leu Asn Gly Glu Pro Ile Gly Tyr Ala Gln Ser Tyr Val Ala Leu 
                85                  90                  95      


Gly Ser Gly Asp Gly Arg Trp Glu Glu Glu Thr Asp Pro Gly Val Arg 
            100                 105                 110         


Gly Ile Asp Gln Leu Leu Ala Asn Ala Ser Gln Leu Gly Lys Gly Leu 
        115                 120                 125             


Gly Thr Lys Leu Val Arg Ala Leu Val Glu Leu Leu Phe Asn Asp Pro 
    130                 135                 140                 


Glu Val Thr Lys Ile Gln Thr Asp Pro Ser Pro Ser Asn Leu Arg Ala 
145                 150                 155                 160 


Ile Arg Cys Tyr Glu Lys Ala Gly Phe Glu Arg Gln Gly Thr Val Thr 
                165                 170                 175     


Thr Pro Tyr Gly Pro Ala Val Tyr Met Val Gln Thr Arg Gln Ala Phe 
            180                 185                 190         


Glu Arg Thr Arg Ser Asp Ala His His His His His His Gln Thr Ser 
        195                 200                 205             


Ala Val Gln Gln Lys Leu Ala Ala Leu Glu Lys Ser Ser Gly Gly Arg 
    210                 215                 220                 


Leu Gly Val Ala Leu Ile Asp Thr Ala Asp Asn Thr Gln Val Leu Tyr 
225                 230                 235                 240 


Arg Gly Asp Glu Arg Phe Pro Met Cys Ser Thr Ser Lys Val Met Ala 
                245                 250                 255     


Ala Ala Ala Val Leu Lys Gln Ser Glu Thr Gln Lys Gln Leu Leu Asn 
            260                 265                 270         


Gln Pro Val Glu Ile Lys Pro Ala Asp Leu Val Asn Tyr Asn Pro Ile 
        275                 280                 285             


Ala Glu Lys His Val Asn Gly Thr Met Thr Leu Ala Glu Leu Ser Ala 
    290                 295                 300                 


Ala Ala Leu Gln Tyr Ser Asp Asn Thr Ala Met Asn Lys Leu Ile Ala 
305                 310                 315                 320 


Gln Leu Gly Gly Pro Gly Gly Val Thr Ala Phe Ala Arg Ala Ile Gly 
                325                 330                 335     


Asp Glu Thr Phe Arg Leu Asp Arg Thr Glu Pro Thr Leu Asn Thr Ala 
            340                 345                 350         


Ile Pro Gly Asp Pro Arg Asp Thr Thr Thr Pro Arg Ala Met Ala Gln 
        355                 360                 365             


Thr Leu Arg Gln Leu Thr Leu Gly His Ala Leu Gly Glu Thr Gln Arg 
    370                 375                 380                 


Ala Gln Leu Val Thr Trp Leu Lys Gly Asn Thr Thr Gly Ala Ala Ser 
385                 390                 395                 400 


Ile Arg Ala Gly Leu Pro Thr Ser Trp Thr Ala Gly Asp Lys Thr Gly 
                405                 410                 415     


Ser Gly Gly Tyr Gly Thr Thr Asn Asp Ile Ala Val Ile Trp Pro Gln 
            420                 425                 430         


Gly Arg Ala Pro Leu Val Leu Val Thr Tyr Phe Thr Gln Pro Gln Gln 
        435                 440                 445             


Asn Ala Glu Ser Arg Arg Asp Val Leu Ala Ser Ala Ala Arg Ile Ile 
    450                 455                 460                 


Ala Glu Gly Leu 
465


<210>  22
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fusion 6 EreB-H6-TEM36

<400>  22

Met Arg Phe Glu Glu Trp Val Lys Asp Lys His Ile Pro Phe Lys Leu 
1               5                   10                  15      


Asn His Pro Asp Asp Asn Tyr Asp Asp Phe Lys Pro Leu Arg Lys Ile 
            20                  25                  30          


Ile Gly Asp Thr Arg Val Val Ala Leu Gly Glu Asn Ser His Phe Ile 
        35                  40                  45              


Lys Glu Phe Phe Leu Leu Arg His Thr Leu Leu Arg Phe Phe Ile Glu 
    50                  55                  60                  


Asp Leu Gly Phe Thr Thr Phe Ala Phe Glu Phe Gly Phe Ala Glu Gly 
65                  70                  75                  80  


Gln Ile Ile Asn Asn Trp Ile His Gly Gln Gly Thr Asp Asp Glu Ile 
                85                  90                  95      


Gly Arg Phe Leu Lys His Phe Tyr Tyr Pro Glu Glu Leu Lys Thr Thr 
            100                 105                 110         


Phe Leu Trp Leu Arg Glu Tyr Asn Lys Ala Ala Lys Glu Lys Ile Thr 
        115                 120                 125             


Phe Leu Gly Ile Asp Ile Pro Arg Asn Gly Gly Ser Tyr Leu Pro Asn 
    130                 135                 140                 


Met Glu Ile Val His Asp Phe Phe Arg Thr Ala Asp Lys Glu Ala Leu 
145                 150                 155                 160 


His Ile Ile Asp Asp Ala Phe Asn Ile Ala Lys Lys Ile Asp Tyr Phe 
                165                 170                 175     


Ser Thr Ser Gln Ala Ala Leu Asn Leu His Glu Leu Thr Asp Ser Glu 
            180                 185                 190         


Lys Cys Arg Leu Thr Ser Gln Leu Ala Arg Val Lys Val Arg Leu Glu 
        195                 200                 205             


Ala Met Ala Pro Ile His Ile Glu Lys Tyr Gly Ile Asp Lys Tyr Glu 
    210                 215                 220                 


Thr Ile Leu His Tyr Ala Asn Gly Met Ile Tyr Leu Asp Tyr Asn Ile 
225                 230                 235                 240 


Gln Ala Met Ser Gly Phe Ile Ser Gly Gly Gly Met Gln Gly Asp Met 
                245                 250                 255     


Gly Ala Lys Asp Lys Tyr Met Ala Asp Ser Val Leu Trp His Leu Lys 
            260                 265                 270         


Asn Pro Gln Ser Glu Gln Lys Val Ile Val Val Ala His Asn Ala His 
        275                 280                 285             


Ile Gln Lys Thr Pro Ile Leu Tyr Asp Gly Phe Leu Ser Cys Leu Pro 
    290                 295                 300                 


Met Gly Gln Arg Leu Lys Asn Ala Ile Gly Asp Asp Tyr Met Ser Leu 
305                 310                 315                 320 


Gly Ile Thr Ser Tyr Ser Gly His Thr Ala Ala Leu Tyr Pro Glu Val 
                325                 330                 335     


Asp Thr Lys Tyr Gly Phe Arg Val Asp Asn Phe Gln Leu Gln Glu Pro 
            340                 345                 350         


Asn Glu Gly Ser Val Glu Lys Ala Ile Ser Gly Cys Gly Val Thr Asn 
        355                 360                 365             


Ser Phe Val Phe Phe Arg Asn Ile Pro Glu Asp Leu Gln Ser Ile Pro 
    370                 375                 380                 


Asn Met Ile Arg Phe Asp Ser Ile Tyr Met Lys Ala Glu Leu Glu Lys 
385                 390                 395                 400 


Ala Phe Asp Gly Ile Phe Gln Ile Glu Lys Ser Ser Val Ser Glu Val 
                405                 410                 415     


Val Tyr Glu His His His His His His His Pro Glu Thr Leu Val Lys 
            420                 425                 430         


Val Lys Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu 
        435                 440                 445             


Leu Asp Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu 
    450                 455                 460                 


Arg Phe Pro Met Val Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val 
465                 470                 475                 480 


Leu Ser Arg Val Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His 
                485                 490                 495     


Tyr Ser Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His 
            500                 505                 510         


Leu Thr Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr 
        515                 520                 525             


Met Ser Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly 
    530                 535                 540                 


Pro Lys Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr 
545                 550                 555                 560 


Arg Leu Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp 
                565                 570                 575     


Glu Arg Asp Thr Thr Met Pro Ala Ala Met Ala Thr Thr Leu Arg Lys 
            580                 585                 590         


Leu Leu Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile 
        595                 600                 605             


Asp Trp Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala 
    610                 615                 620                 


Leu Pro Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg 
625                 630                 635                 640 


Gly Ser Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser 
                645                 650                 655     


Arg Ile Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu 
            660                 665                 670         


Arg Asp Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        675                 680                 685             


<210>  23
<211>  18
<212>  DNA
<213>  Pichia pastoris

<400>  23
gagggtgtct ctctcgag                                                     18


<210>  24
<211>  36
<212>  DNA
<213>  Pichia pastoris

<400>  24
tccacctcca cctcctcccc aatgtttgat taggga                                 36


<210>  25
<211>  39
<212>  DNA
<213>  Pichia pastoris

<400>  25
ggaggtggag gtggacagac gtcagccgtg cagcaaaag                              39


<210>  26
<211>  30
<212>  DNA
<213>  Pichia pastoris

<400>  26
gctaggcggc cgcttttaca aaccttcagc                                        30


<210>  27
<211>  18
<212>  DNA
<213>  Pichia pastoris

<400>  27
gagggtgtct ctctcgag                                                     18


<210>  28
<211>  39
<212>  DNA
<213>  Pichia pastoris

<400>  28
tcctcctcct cctcctccca aaccttcagc tatgatccg                              39


<210>  29
<211>  39
<212>  DNA
<213>  Pichia pastoris

<400>  29
ggaggaggag gaggaggaca ccctgagaca cttgtcaag                              39


<210>  30
<211>  18
<212>  DNA
<213>  Pichia pastoris

<400>  30
ttgagcggcc gcccctca                                                     18


<210>  31
<211>  45
<212>  DNA
<213>  Pichia pastoris

<400>  31
tgctgcctct ttagcggccg cctctcccca atgtttgatt aggga                       45


<210>  32
<211>  39
<212>  DNA
<213>  Pichia pastoris

<400>  32
gccgctaaag aggcagcagc aaaacagacg tcagccgtg                              39


<210>  33
<211>  24
<212>  DNA
<213>  Escherichia coli

<400>  33
taatacgact cactataggg gaat                                              24


<210>  34
<211>  36
<212>  DNA
<213>  Escherichia coli

<400>  34
tcctcctcct cctcctcccc aatgtttaat caggct                                 36


<210>  35
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  35
ggaggaggag gaggacagac gtcagccgtg cagcaaaag                              39


<210>  36
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  36
tcctcctcct cctcctccca aaccttcagc tatgatccg                              39


<210>  37
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  37
ggaggaggag gaggaggaca ccctgagaca cttgtcaag                              39


<210>  38
<211>  21
<212>  DNA
<213>  Escherichia coli

<400>  38
ctagttattg ctcagcggtg g                                                 21


<210>  39
<211>  27
<212>  DNA
<213>  Escherichia coli

<400>  39
gaaggagata tacatatgag caacgct                                           27


<210>  40
<211>  21
<212>  DNA
<213>  Escherichia coli

<400>  40
gtggtgatga tggtggtgcg c                                                 21


<210>  41
<211>  39
<212>  DNA
<213>  Escherichia coli

<400>  41
caccatcatc accaccagac gtcagccgtg cagcaaaag                              39


<210>  42
<211>  27
<212>  DNA
<213>  Escherichia coli

<400>  42
gatatacata tgcgttttga agagtgg                                           27


<210>  43
<211>  27
<212>  DNA
<213>  Escherichia coli

<400>  43
gtgatggtga tggtggtgct cataaac                                           27


<210>  44
<211>  42
<212>  DNA
<213>  Escherichia coli

<400>  44
caccaccatc accatcacca cccggaaacc ctggtgaaag tt                          42



37


