                         SEQUENCE LISTING

<110>  STALLERGENES SA
 
<120>  Markers of immune response

<130>  BET15P3011

<150>  EP14306733.8
<151>  2014-10-29

<160>  261   

<170>  PatentIn version 3.5

<210>  1
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
        195                 200                 205             


Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Thr Pro Pro Asp 
    210                 215                 220                 


Leu Asn Ser Pro Thr Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn 
225                 230                 235                 240 


Ser Glu Ile Asp Thr Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu 
                245                 250                 255     


Thr Asn Gly Ile Thr Ser Cys Ser Leu Pro Arg Pro Thr Pro Gln Ala 
            260                 265                 270         


Ser Phe Leu Pro Glu Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro 
        275                 280                 285             


Thr Pro Asn Pro Asp Pro Phe Arg Asp Asp Pro Phe Thr Gln Pro Asp 
    290                 295                 300                 


Gln Ser Thr Pro Ser Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys 
305                 310                 315                 320 


Lys Glu Asn Ser Ser Ser Ser Ser Thr Pro Leu Ser Asn Gly Pro Leu 
                325                 330                 335     


Asn Gly Asp Val Asp Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn 
            340                 345                 350         


Arg Thr Gly Lys Gln Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser 
        355                 360                 365             


Ser Gln Thr Gln Pro Ala Val Arg Thr Gln Asn Gly Val Ser Glu Arg 
    370                 375                 380                 


Glu Gln Asn Gly Phe Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly 
385                 390                 395                 400 


Ser Pro Pro Lys Gly Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu 
                405                 410                 415     


Glu Ser Ser Val Gln Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro 
            420                 425                 430         


Pro Pro Gln Ser Thr Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser 
        435                 440                 445             


Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser 
    450                 455                 460                 


Glu Pro Ser Gly Gln Ala Ser Pro Thr Gly Gln Pro Thr Ala Leu Gln 
465                 470                 475                 480 


Pro Asn Pro Leu Asp Leu Phe Lys Thr Ser Ala Pro Ala Pro Val Gly 
                485                 490                 495     


Pro Leu Val Gly Leu Gly Gly Val Thr Val Thr Leu Pro Gln Ala Gly 
            500                 505                 510         


Pro Trp Asn Thr Ala Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala 
        515                 520                 525             


Pro Gly Ala Met Met Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val 
    530                 535                 540                 


Ile Phe Gly Thr Ser Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro 
545                 550                 555                 560 


Phe Ala Ala Ser Thr Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser 
                565                 570                 575     


Ala Ser Val Ala Pro Asn Ala Trp Ser Thr Thr Ser Pro Leu Gly Asn 
            580                 585                 590         


Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro Ala Val Ser Thr Gln Pro 
        595                 600                 605             


Pro Ser Met His Ser Ser Leu Leu Val Thr Pro Pro Gln Pro Pro Pro 
    610                 615                 620                 


Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser Asp Ala Phe Thr Ala Leu 
625                 630                 635                 640 


Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys 
                645                 650                 655     


Asp Phe Gln Leu Arg Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu 
            660                 665                 670         


Gln Thr Ser Ser Gly Thr Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser 
        675                 680                 685             


Lys Val Gly Ile Pro Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala 
    690                 695                 700                 


Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg 
705                 710                 715                 720 


Gln Val Ser Leu Pro Val Thr Lys Ser Thr Asp Asn Ala Phe Glu Asn 
                725                 730                 735     


Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser 
            740                 745                 750         


Ser Gln Pro Val Ser Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro 
        755                 760                 765             


Phe Ala 
    770 


<210>  2
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
        195                 200                 205             


Gly Val Asp Gln Met Asp Leu Phe Gly Asp Met Ser Thr Pro Pro Asp 
    210                 215                 220                 


Leu Asn Ser Pro Thr Ser Ser Ala Asn Asp Leu Leu Ala Ser Asp Ile 
225                 230                 235                 240 


Phe Ala Pro Pro Val Ser Glu Pro Ser Gly Gln Ala Ser Pro Thr Gly 
                245                 250                 255     


Gln Pro Thr Ala Leu Gln Pro Asn Pro Leu Asp Leu Phe Lys Thr Ser 
            260                 265                 270         


Ala Pro Ala Pro Val Gly Pro Leu Val Gly Leu Gly Gly Val Thr Val 
        275                 280                 285             


Thr Leu Pro Gln Ala Gly Pro Trp Asn Thr Ala Ser Leu Val Phe Asn 
    290                 295                 300                 


Gln Ser Pro Ser Met Ala Pro Gly Ala Met Met Gly Gly Gln Pro Ser 
305                 310                 315                 320 


Gly Phe Ser Gln Pro Val Ile Phe Gly Thr Ser Pro Ala Val Ser Gly 
                325                 330                 335     


Trp Asn Gln Pro Ser Pro Phe Ala Ala Ser Thr Pro Pro Pro Val Pro 
            340                 345                 350         


Val Val Trp Gly Pro Ser Ala Ser Val Ala Pro Asn Ala Trp Ser Thr 
        355                 360                 365             


Thr Ser Pro Leu Gly Asn Pro Phe Gln Ser Asn Ile Phe Pro Ala Pro 
    370                 375                 380                 


Ala Val Ser Thr Gln Pro Pro Ser Met His Ser Ser Leu Leu Val Thr 
385                 390                 395                 400 


Pro Pro Gln Pro Pro Pro Arg Ala Gly Pro Pro Lys Asp Ile Ser Ser 
                405                 410                 415     


Asp Ala Phe Thr Ala Leu Asp Pro Leu Gly Asp Lys Glu Ile Lys Asp 
            420                 425                 430         


Val Lys Glu Met Phe Lys Asp Phe Gln Leu Arg Gln Pro Pro Ala Val 
        435                 440                 445             


Pro Ala Arg Lys Gly Glu Gln Thr Ser Ser Gly Thr Leu Ser Ala Phe 
    450                 455                 460                 


Ala Ser Tyr Phe Asn Ser Lys Val Gly Ile Pro Gln Glu Asn Ala Asp 
465                 470                 475                 480 


His Asp Asp Phe Asp Ala Asn Gln Leu Leu Asn Lys Ile Asn Glu Pro 
                485                 490                 495     


Pro Lys Pro Ala Pro Arg Gln Val Ser Leu Pro Val Thr Lys Ser Thr 
            500                 505                 510         


Asp Asn Ala Phe Glu Asn Pro Phe Phe Lys Asp Ser Phe Gly Ser Ser 
        515                 520                 525             


Gln Ala Ser Val Ala Ser Ser Gln Pro Val Ser Ser Glu Met Tyr Arg 
    530                 535                 540                 


Asp Pro Phe Gly Asn Pro Phe Ala 
545                 550         


<210>  3
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Asn Glu Val Glu Thr Ser Ala Thr Asn Gly Gln Pro Asp Gln 
1               5                   10                  15      


Gln Ala Ala Pro Lys Ala Pro Ser Lys Lys Glu Lys Lys Lys Gly Pro 
            20                  25                  30          


Glu Lys Thr Asp Glu Tyr Leu Leu Ala Arg Phe Lys Gly Asp Gly Val 
        35                  40                  45              


Lys Tyr Lys Ala Lys Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
    50                  55                  60                  


Gly Asp Lys Met Ser Gln Asp Ser Met Met Lys Leu Lys Gly Met Ala 
65                  70                  75                  80  


Ala Ala Gly Arg Ser Gln Gly Gln His Lys Gln Arg Ile Trp Val Asn 
                85                  90                  95      


Ile Ser Leu Ser Gly Ile Lys Ile Ile Asp Glu Lys Thr Gly Val Ile 
            100                 105                 110         


Glu His Glu His Pro Val Asn Lys Ile Ser Phe Ile Ala Arg Asp Val 
        115                 120                 125             


Thr Asp Asn Arg Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His 
    130                 135                 140                 


Gln Phe Phe Ala Ile Lys Thr Gly Gln Gln Ala Glu Pro Leu Val Val 
145                 150                 155                 160 


Asp Leu Lys Asp Leu Phe Gln Val Ile Tyr Asn Val Lys Lys Lys Glu 
                165                 170                 175     


Glu Glu Lys Lys Lys Ile Glu Glu Ala Ser Lys Ala Val Glu Asn Gly 
            180                 185                 190         


Ser Glu Ala Leu Met Ile Leu Asp Asp Gln Thr Asn Lys Leu Lys Ser 
        195                 200                 205             


Glu Ser Lys Asp Ile Leu Leu Val Asp Leu Asn Ser Glu Ile Asp Thr 
    210                 215                 220                 


Asn Gln Asn Ser Leu Arg Glu Asn Pro Phe Leu Thr Asn Gly Ile Thr 
225                 230                 235                 240 


Ser Cys Ser Leu Pro Arg Pro Thr Pro Gln Ala Ser Phe Leu Pro Glu 
                245                 250                 255     


Asn Ala Phe Ser Ala Asn Leu Asn Phe Phe Pro Thr Pro Asn Pro Asp 
            260                 265                 270         


Pro Phe Arg Asp Asp Pro Phe Thr Gln Pro Asp Gln Ser Thr Pro Ser 
        275                 280                 285             


Ser Phe Asp Ser Leu Lys Ser Pro Asp Gln Lys Lys Glu Asn Ser Ser 
    290                 295                 300                 


Ser Ser Ser Thr Pro Leu Ser Asn Gly Pro Leu Asn Gly Asp Val Asp 
305                 310                 315                 320 


Tyr Phe Gly Gln Gln Phe Asp Gln Ile Ser Asn Arg Thr Gly Lys Gln 
                325                 330                 335     


Glu Ala Gln Ala Gly Pro Trp Pro Phe Ser Ser Ser Gln Thr Gln Pro 
            340                 345                 350         


Ala Val Arg Thr Gln Asn Gly Val Ser Glu Arg Glu Gln Asn Gly Phe 
        355                 360                 365             


Ser Val Lys Ser Ser Pro Asn Pro Phe Val Gly Ser Pro Pro Lys Gly 
    370                 375                 380                 


Leu Ser Ile Gln Asn Gly Val Lys Gln Asp Leu Glu Ser Ser Val Gln 
385                 390                 395                 400 


Ser Ser Pro His Asp Ser Ile Ala Ile Ile Pro Pro Pro Gln Ser Thr 
                405                 410                 415     


Lys Pro Gly Arg Gly Arg Arg Thr Ala Lys Ser Ser Ala Asn Asp Leu 
            420                 425                 430         


Leu Ala Ser Asp Ile Phe Ala Pro Pro Val Ser Glu Pro Ser Gly Gln 
        435                 440                 445             


Ala Ser Pro Thr Gly Gln Pro Thr Ala Leu Gln Pro Asn Pro Leu Asp 
    450                 455                 460                 


Leu Phe Lys Thr Ser Ala Pro Ala Pro Val Gly Pro Leu Val Gly Leu 
465                 470                 475                 480 


Gly Gly Val Thr Val Thr Leu Pro Gln Ala Gly Pro Trp Asn Thr Ala 
                485                 490                 495     


Ser Leu Val Phe Asn Gln Ser Pro Ser Met Ala Pro Gly Ala Met Met 
            500                 505                 510         


Gly Gly Gln Pro Ser Gly Phe Ser Gln Pro Val Ile Phe Gly Thr Ser 
        515                 520                 525             


Pro Ala Val Ser Gly Trp Asn Gln Pro Ser Pro Phe Ala Ala Ser Thr 
    530                 535                 540                 


Pro Pro Pro Val Pro Val Val Trp Gly Pro Ser Ala Ser Val Ala Pro 
545                 550                 555                 560 


Asn Ala Trp Ser Thr Thr Ser Pro Leu Gly Asn Pro Phe Gln Ser Asn 
                565                 570                 575     


Ile Phe Pro Ala Pro Ala Val Ser Thr Gln Pro Pro Ser Met His Ser 
            580                 585                 590         


Ser Leu Leu Val Thr Pro Pro Gln Pro Pro Pro Arg Ala Gly Pro Pro 
        595                 600                 605             


Lys Asp Ile Ser Ser Asp Ala Phe Thr Ala Leu Asp Pro Leu Gly Asp 
    610                 615                 620                 


Lys Glu Ile Lys Asp Val Lys Glu Met Phe Lys Asp Phe Gln Leu Arg 
625                 630                 635                 640 


Gln Pro Pro Ala Val Pro Ala Arg Lys Gly Glu Gln Thr Ser Ser Gly 
                645                 650                 655     


Thr Leu Ser Ala Phe Ala Ser Tyr Phe Asn Ser Lys Val Gly Ile Pro 
            660                 665                 670         


Gln Glu Asn Ala Asp His Asp Asp Phe Asp Ala Asn Gln Leu Leu Asn 
        675                 680                 685             


Lys Ile Asn Glu Pro Pro Lys Pro Ala Pro Arg Gln Val Ser Leu Pro 
    690                 695                 700                 


Val Thr Lys Ser Thr Asp Asn Ala Phe Glu Asn Pro Phe Phe Lys Asp 
705                 710                 715                 720 


Ser Phe Gly Ser Ser Gln Ala Ser Val Ala Ser Ser Gln Pro Val Ser 
                725                 730                 735     


Ser Glu Met Tyr Arg Asp Pro Phe Gly Asn Pro Phe Ala 
            740                 745                 


<210>  4
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro 
        35                  40                  45              


Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly 
    50                  55                  60                  


Ala Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn 
65                  70                  75                  80  


Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser 
            100                 105                 110         


Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr 
        115                 120                 125             


Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His 
    130                 135                 140                 


Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly 
145                 150                 155                 160 


Lys Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly 
            180                 185                 190         


Tyr Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro 
        195                 200                 205             


Ser Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile 
    210                 215                 220                 


Ala Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr 
225                 230                 235                 240 


Cys Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala 
                245                 250                 255     


Ala Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg 
            260                 265                 270         


Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr 
        275                 280                 285             


Met Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr 
    290                 295                 300                 


Leu Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315         


<210>  5
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Met Glu Thr Gln Met Ser Gln Asn Val Cys Pro Arg Asn Leu 
1               5                   10                  15      


Trp Leu Leu Gln Pro Leu Thr Val Leu Leu Leu Leu Ala Ser Ala Asp 
            20                  25                  30          


Ser Gln Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp 
        35                  40                  45              


Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala 
    50                  55                  60                  


Arg Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu 
65                  70                  75                  80  


Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn 
                85                  90                  95      


Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp 
            100                 105                 110         


Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro 
        115                 120                 125             


His Leu Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His Ser 
    130                 135                 140                 


Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys 
145                 150                 155                 160 


Ser Gln Lys Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala 
                165                 170                 175     


Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr 
            180                 185                 190         


Thr Leu Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val Pro Ser 
        195                 200                 205             


Met Gly Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Ile Ala 
    210                 215                 220                 


Thr Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys 
225                 230                 235                 240 


Arg Lys Lys Arg Ile Ser Ala Asn Ser Thr Asp Pro Val Lys Ala Ala 
                245                 250                 255     


Gln Phe Glu Pro Pro Gly Arg Gln Met Ile Ala Ile Arg Lys Arg Gln 
            260                 265                 270         


Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly Tyr Met 
        275                 280                 285             


Thr Leu Asn Pro Arg Ala Pro Thr Asp Asp Asp Lys Asn Ile Tyr Leu 
    290                 295                 300                 


Thr Leu Pro Pro Asn Asp His Val Asn Ser Asn Asn 
305                 310                 315     


<210>  6
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala 
1               5                   10                  15      


Val Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu 
            20                  25                  30          


Ser Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val 
        35                  40                  45              


Ser His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu 
    50                  55                  60                  


Arg Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln 
65                  70                  75                  80  


Asp Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala 
                85                  90                  95      


Met Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu 
            100                 105                 110         


Asp Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp 
        115                 120                 125             


Phe Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys 
    130                 135                 140                 


Met Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala 
145                 150                 155                 160 


Gly Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 175 


<210>  7
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Asp Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp 
                725                 730                 735     


Gly Thr 
        


<210>  8
<211>  720
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Glu Pro Leu Asn Ser Asp Val Gln Tyr 
            660                 665                 670         


Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu Gly Lys 
        675                 680                 685             


Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val Pro Asp 
    690                 695                 700                 


Ala Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr 
705                 710                 715                 720 


<210>  9
<211>  717
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Asp Leu Gly Lys Lys Asp Thr 
        675                 680                 685             


Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val Pro Asp Ala Val Glu 
    690                 695                 700                 


Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr 
705                 710                 715         


<210>  10
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Ala 
    690                 695                 700                 


Val Glu Ser Arg Tyr Ser Arg Thr Glu Gly Ser Leu Asp Gly Thr 
705                 710                 715                 


<210>  11
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Glu Asn 
    690                 695                 700                 


Gly Arg Leu Pro 
705             


<210>  12
<211>  727
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gln Pro Arg Trp Ala Gln Gly Ala Thr Met Trp Leu Gly Val Leu 
1               5                   10                  15      


Leu Thr Leu Leu Leu Cys Ser Ser Leu Glu Gly Gln Glu Asn Ser Phe 
            20                  25                  30          


Thr Ile Asn Ser Val Asp Met Lys Ser Leu Pro Asp Trp Thr Val Gln 
        35                  40                  45              


Asn Gly Lys Asn Leu Thr Leu Gln Cys Phe Ala Asp Val Ser Thr Thr 
    50                  55                  60                  


Ser His Val Lys Pro Gln His Gln Met Leu Phe Tyr Lys Asp Asp Val 
65                  70                  75                  80  


Leu Phe Tyr Asn Ile Ser Ser Met Lys Ser Thr Glu Ser Tyr Phe Ile 
                85                  90                  95      


Pro Glu Val Arg Ile Tyr Asp Ser Gly Thr Tyr Lys Cys Thr Val Ile 
            100                 105                 110         


Val Asn Asn Lys Glu Lys Thr Thr Ala Glu Tyr Gln Leu Leu Val Glu 
        115                 120                 125             


Gly Val Pro Ser Pro Arg Val Thr Leu Asp Lys Lys Glu Ala Ile Gln 
    130                 135                 140                 


Gly Gly Ile Val Arg Val Asn Cys Ser Val Pro Glu Glu Lys Ala Pro 
145                 150                 155                 160 


Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys Met Val Lys 
                165                 170                 175     


Leu Lys Arg Glu Lys Asn Ser Arg Asp Gln Asn Phe Val Ile Leu Glu 
            180                 185                 190         


Phe Pro Val Glu Glu Gln Asp Arg Val Leu Ser Phe Arg Cys Gln Ala 
        195                 200                 205             


Arg Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys Ser 
    210                 215                 220                 


Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys Phe His Ile 
225                 230                 235                 240 


Ser Pro Thr Gly Met Ile Met Glu Gly Ala Gln Leu His Ile Lys Cys 
                245                 250                 255     


Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile Ile 
            260                 265                 270         


Gln Lys Asp Lys Ala Ile Val Ala His Asn Arg His Gly Asn Lys Ala 
        275                 280                 285             


Val Tyr Ser Val Met Ala Met Val Glu His Ser Gly Asn Tyr Thr Cys 
    290                 295                 300                 


Lys Val Glu Ser Ser Arg Ile Ser Lys Val Ser Ser Ile Val Val Asn 
305                 310                 315                 320 


Ile Thr Glu Leu Phe Ser Lys Pro Glu Leu Glu Ser Ser Phe Thr His 
                325                 330                 335     


Leu Asp Gln Gly Glu Arg Leu Asn Leu Ser Cys Ser Ile Pro Gly Ala 
            340                 345                 350         


Pro Pro Ala Asn Phe Thr Ile Gln Lys Glu Asp Thr Ile Val Ser Gln 
        355                 360                 365             


Thr Gln Asp Phe Thr Lys Ile Ala Ser Lys Ser Asp Ser Gly Thr Tyr 
    370                 375                 380                 


Ile Cys Thr Ala Gly Ile Asp Lys Val Val Lys Lys Ser Asn Thr Val 
385                 390                 395                 400 


Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg Ile Ser Tyr Asp 
                405                 410                 415     


Ala Gln Phe Glu Val Ile Lys Gly Gln Thr Ile Glu Val Arg Cys Glu 
            420                 425                 430         


Ser Ile Ser Gly Thr Leu Pro Ile Ser Tyr Gln Leu Leu Lys Thr Ser 
        435                 440                 445             


Lys Val Leu Glu Asn Ser Thr Lys Asn Ser Asn Asp Pro Ala Val Phe 
    450                 455                 460                 


Lys Asp Asn Pro Thr Glu Asp Val Glu Tyr Gln Cys Val Ala Asp Asn 
465                 470                 475                 480 


Cys His Ser His Ala Lys Met Leu Ser Glu Val Leu Arg Val Lys Val 
                485                 490                 495     


Ile Ala Pro Val Asp Glu Val Gln Ile Ser Ile Leu Ser Ser Lys Val 
            500                 505                 510         


Val Glu Ser Gly Glu Asp Ile Val Leu Gln Cys Ala Val Asn Glu Gly 
        515                 520                 525             


Ser Gly Pro Ile Thr Tyr Lys Phe Tyr Arg Glu Lys Glu Gly Lys Pro 
    530                 535                 540                 


Phe Tyr Gln Met Thr Ser Asn Ala Thr Gln Ala Phe Trp Thr Lys Gln 
545                 550                 555                 560 


Lys Ala Ser Lys Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn 
                565                 570                 575     


Arg Ala Asn His Ala Ser Ser Val Pro Arg Ser Lys Ile Leu Thr Val 
            580                 585                 590         


Arg Val Ile Leu Ala Pro Trp Lys Lys Gly Leu Ile Ala Val Val Ile 
        595                 600                 605             


Ile Gly Val Ile Ile Ala Leu Leu Ile Ile Ala Ala Lys Cys Tyr Phe 
    610                 615                 620                 


Leu Arg Lys Ala Lys Ala Lys Gln Met Pro Val Glu Met Ser Arg Pro 
625                 630                 635                 640 


Ala Val Pro Leu Leu Asn Ser Asn Asn Glu Lys Met Ser Asp Pro Asn 
                645                 650                 655     


Met Glu Ala Asn Ser His Tyr Gly His Asn Asp Asp Val Arg Asn His 
            660                 665                 670         


Ala Met Lys Pro Ile Asn Asp Asn Lys Glu Pro Leu Asn Ser Asp Val 
        675                 680                 685             


Gln Tyr Thr Glu Val Gln Val Ser Ser Ala Glu Ser His Lys Asp Leu 
    690                 695                 700                 


Gly Lys Lys Asp Thr Glu Thr Val Tyr Ser Glu Val Arg Lys Ala Val 
705                 710                 715                 720 


Pro Glu Asn Gly Arg Leu Pro 
                725         


<210>  13
<211>  709
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Pro Arg Ile Gly Pro Ala Gly Glu Val Pro Gln Val Pro Asp 
1               5                   10                  15      


Lys Glu Thr Lys Ala Thr Met Gly Thr Glu Asn Thr Pro Gly Gly Lys 
            20                  25                  30          


Ala Ser Pro Asp Pro Gln Asp Val Arg Pro Ser Val Phe His Asn Ile 
        35                  40                  45              


Lys Leu Phe Val Leu Cys His Ser Leu Leu Gln Leu Ala Gln Leu Met 
    50                  55                  60                  


Ile Ser Gly Tyr Leu Lys Ser Ser Ile Ser Thr Val Glu Lys Arg Phe 
65                  70                  75                  80  


Gly Leu Ser Ser Gln Thr Ser Gly Leu Leu Ala Ser Phe Asn Glu Val 
                85                  90                  95      


Gly Asn Thr Ala Leu Ile Val Phe Val Ser Tyr Phe Gly Ser Arg Val 
            100                 105                 110         


His Arg Pro Arg Met Ile Gly Tyr Gly Ala Ile Leu Val Ala Leu Ala 
        115                 120                 125             


Gly Leu Leu Met Thr Leu Pro His Phe Ile Ser Glu Pro Tyr Arg Tyr 
    130                 135                 140                 


Asp Asn Thr Ser Pro Glu Asp Met Pro Gln Asp Phe Lys Ala Ser Leu 
145                 150                 155                 160 


Cys Leu Pro Thr Thr Ser Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn 
                165                 170                 175     


Cys Ser Ser Tyr Thr Glu Thr Gln His Leu Ser Val Val Gly Ile Met 
            180                 185                 190         


Phe Val Ala Gln Thr Leu Leu Gly Val Gly Gly Val Pro Ile Gln Pro 
        195                 200                 205             


Phe Gly Ile Ser Tyr Ile Asp Asp Phe Ala His Asn Ser Asn Ser Pro 
    210                 215                 220                 


Leu Tyr Leu Gly Ile Leu Phe Ala Val Thr Met Met Gly Pro Gly Leu 
225                 230                 235                 240 


Ala Phe Gly Leu Gly Ser Leu Met Leu Arg Leu Tyr Val Asp Ile Asn 
                245                 250                 255     


Gln Met Pro Glu Gly Gly Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp 
            260                 265                 270         


Val Gly Ala Trp Trp Leu Gly Phe Leu Ile Ala Ala Gly Ala Val Ala 
        275                 280                 285             


Leu Ala Ala Ile Pro Tyr Phe Phe Phe Pro Lys Glu Met Pro Lys Glu 
    290                 295                 300                 


Lys Arg Glu Leu Gln Phe Arg Arg Lys Val Leu Ala Val Thr Asp Ser 
305                 310                 315                 320 


Pro Ala Arg Lys Gly Lys Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu 
                325                 330                 335     


Ser Thr Lys Lys Gln Asp Gly Leu Val Gln Ile Ala Pro Asn Leu Thr 
            340                 345                 350         


Val Ile Gln Phe Ile Lys Val Phe Pro Arg Val Leu Leu Gln Thr Leu 
        355                 360                 365             


Arg His Pro Ile Phe Leu Leu Val Val Leu Ser Gln Val Cys Leu Ser 
    370                 375                 380                 


Ser Met Ala Ala Gly Met Ala Ile Phe Leu Pro Lys Phe Leu Glu Arg 
385                 390                 395                 400 


Gln Phe Ser Ile Thr Ala Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu 
                405                 410                 415     


Ser Phe Pro Ser Val Ile Val Gly Ile Val Val Gly Gly Val Leu Val 
            420                 425                 430         


Lys Arg Leu His Leu Gly Pro Val Gly Cys Gly Ala Leu Cys Leu Leu 
        435                 440                 445             


Gly Met Leu Leu Cys Leu Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly 
    450                 455                 460                 


Cys Ser Ser His Gln Ile Ala Gly Ile Thr His Gln Thr Ser Ala His 
465                 470                 475                 480 


Pro Gly Leu Glu Leu Ser Pro Ser Cys Met Glu Ala Cys Ser Cys Pro 
                485                 490                 495     


Leu Asp Gly Phe Asn Pro Val Cys Asp Pro Ser Thr Arg Val Glu Tyr 
            500                 505                 510         


Ile Thr Pro Cys His Ala Gly Cys Ser Ser Trp Val Val Gln Asp Ala 
        515                 520                 525             


Leu Asp Asn Ser Gln Val Phe Tyr Thr Asn Cys Ser Cys Val Val Glu 
    530                 535                 540                 


Gly Asn Pro Val Leu Ala Gly Ser Cys Asp Ser Thr Cys Ser His Leu 
545                 550                 555                 560 


Val Val Pro Phe Leu Leu Leu Val Ser Leu Gly Ser Ala Leu Ala Cys 
                565                 570                 575     


Leu Thr His Thr Pro Ser Phe Met Leu Ile Leu Arg Gly Val Lys Lys 
            580                 585                 590         


Glu Asp Lys Thr Leu Ala Val Gly Ile Gln Phe Met Phe Leu Arg Ile 
        595                 600                 605             


Leu Ala Trp Met Pro Ser Pro Val Ile His Gly Ser Ala Ile Asp Thr 
    610                 615                 620                 


Thr Cys Val His Trp Ala Leu Ser Cys Gly Arg Arg Ala Val Cys Arg 
625                 630                 635                 640 


Tyr Tyr Asn Asn Asp Leu Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe 
                645                 650                 655     


Phe Phe Lys Thr Gly Ser Val Ile Cys Phe Ala Leu Val Leu Ala Val 
            660                 665                 670         


Leu Arg Gln Gln Asp Lys Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser 
        675                 680                 685             


Pro Ala Val Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys Lys Pro 
    690                 695                 700                 


Glu Asp Ser Arg Val 
705                 


<210>  14
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ile Gly Tyr Gly Ala Ile Leu Val Ala Leu Ala Gly Leu Leu Met 
1               5                   10                  15      


Thr Leu Pro His Phe Ile Ser Glu Pro Tyr Arg Tyr Asp Asn Thr Ser 
            20                  25                  30          


Pro Gly Gly Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp Val Gly Ala 
        35                  40                  45              


Trp Trp Leu Gly Phe Leu Ile Ala Ala Gly Ala Val Ala Leu Ala Ala 
    50                  55                  60                  


Ile Pro Tyr Phe Phe Phe Pro Lys Glu Met Pro Lys Glu Lys Arg Glu 
65                  70                  75                  80  


Leu Gln Phe Arg Arg Lys Val Leu Ala Val Thr Asp Ser Pro Ala Arg 
                85                  90                  95      


Lys Gly Lys Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu Ser Thr Lys 
            100                 105                 110         


Lys Gln Asp Gly Leu Val Gln Ile Ala Pro Asn Leu Thr Val Ile Gln 
        115                 120                 125             


Phe Ile Lys Val Phe Pro Arg Val Leu Leu Gln Thr Leu Arg His Pro 
    130                 135                 140                 


Ile Phe Leu Leu Val Val Leu Ser Gln Val Cys Leu Ser Ser Met Ala 
145                 150                 155                 160 


Ala Gly Met Ala Ile Phe Leu Pro Lys Phe Leu Glu Arg Gln Phe Ser 
                165                 170                 175     


Ile Thr Ala Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu Ser Phe Pro 
            180                 185                 190         


Ser Val Ile Val Gly Ile Val Val Gly Gly Val Leu Val Lys Arg Leu 
        195                 200                 205             


His Leu Gly Pro Val Gly Cys Gly Ala Leu Cys Leu Leu Gly Met Leu 
    210                 215                 220                 


Leu Cys Leu Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly Cys Ser Ser 
225                 230                 235                 240 


His Gln Ile Ala Gly Ile Thr His Gln Thr Ser Ala His Pro Gly Leu 
                245                 250                 255     


Glu Leu Ser Pro Ser Cys Met Glu Ala Cys Ser Cys Pro Leu Asp Gly 
            260                 265                 270         


Phe Asn Pro Val Cys Asp Pro Ser Thr Arg Val Glu Tyr Ile Thr Pro 
        275                 280                 285             


Cys His Ala Gly Cys Ser Ser Trp Val Val Gln Asp Ala Leu Asp Asn 
    290                 295                 300                 


Ser Gln Val Phe Tyr Thr Asn Cys Ser Cys Val Val Glu Gly Asn Pro 
305                 310                 315                 320 


Val Leu Ala Gly Ser Cys Asp Ser Thr Cys Ser His Leu Val Val Pro 
                325                 330                 335     


Phe Leu Leu Leu Val Ser Leu Gly Ser Ala Leu Ala Cys Leu Thr His 
            340                 345                 350         


Thr Pro Ser Phe Met Leu Ile Leu Arg Gly Val Lys Lys Glu Asp Lys 
        355                 360                 365             


Thr Leu Ala Val Gly Ile Gln Phe Met Phe Leu Arg Ile Leu Ala Trp 
    370                 375                 380                 


Met Pro Ser Pro Val Ile His Gly Ser Ala Ile Asp Thr Thr Cys Val 
385                 390                 395                 400 


His Trp Ala Leu Ser Cys Gly Arg Arg Ala Val Cys Arg Tyr Tyr Asn 
                405                 410                 415     


Asn Asp Leu Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe Phe Phe Lys 
            420                 425                 430         


Thr Gly Ser Val Ile Cys Phe Ala Leu Val Leu Ala Val Leu Arg Gln 
        435                 440                 445             


Gln Asp Lys Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser Pro Ala Val 
    450                 455                 460                 


Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys Lys Pro Glu Asp Ser 
465                 470                 475                 480 


Arg Val 
        


<210>  15
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Thr Glu Asn Thr Pro Gly Gly Lys Ala Ser Pro Asp Pro Gln 
1               5                   10                  15      


Asp Val Arg Pro Ser Val Phe His Asn Ile Lys Leu Phe Val Leu Cys 
            20                  25                  30          


His Ser Leu Leu Gln Leu Ala Gln Leu Met Ile Ser Gly Tyr Leu Lys 
        35                  40                  45              


Ser Ser Ile Ser Thr Val Glu Lys Arg Phe Gly Leu Ser Ser Gln Thr 
    50                  55                  60                  


Ser Gly Leu Leu Ala Ser Phe Asn Glu Val Gly Asn Thr Ala Leu Ile 
65                  70                  75                  80  


Val Phe Val Ser Tyr Phe Gly Ser Arg Val His Arg Pro Arg Met Ile 
                85                  90                  95      


Gly Tyr Gly Ala Ile Leu Val Ala Leu Ala Gly Leu Leu Met Thr Leu 
            100                 105                 110         


Pro His Phe Ile Ser Glu Pro Tyr Arg Tyr Asp Asn Thr Ser Pro Glu 
        115                 120                 125             


Asp Met Pro Gln Asp Phe Lys Ala Ser Leu Cys Leu Pro Thr Thr Ser 
    130                 135                 140                 


Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn Cys Ser Ser Tyr Thr Glu 
145                 150                 155                 160 


Thr Gln His Leu Ser Val Val Gly Ile Met Phe Val Ala Gln Thr Leu 
                165                 170                 175     


Leu Gly Val Gly Gly Val Pro Ile Gln Pro Phe Gly Ile Ser Tyr Ile 
            180                 185                 190         


Asp Asp Phe Ala His Asn Ser Asn Ser Pro Leu Tyr Leu Gly Ile Leu 
        195                 200                 205             


Phe Ala Val Thr Met Met Gly Pro Gly Leu Ala Phe Gly Leu Gly Ser 
    210                 215                 220                 


Leu Met Leu Arg Leu Tyr Val Asp Ile Asn Gln Met Pro Glu Gly Gly 
225                 230                 235                 240 


Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp Val Gly Ala Trp Trp Leu 
                245                 250                 255     


Gly Phe Leu Ile Ala Ala Gly Ala Val Ala Leu Ala Ala Ile Pro Tyr 
            260                 265                 270         


Phe Phe Phe Pro Lys Glu Met Pro Lys Glu Lys Arg Glu Leu Gln Phe 
        275                 280                 285             


Arg Arg Lys Val Leu Ala Val Thr Asp Ser Pro Ala Arg Lys Gly Lys 
    290                 295                 300                 


Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu Ser Thr Lys Lys Gln Asp 
305                 310                 315                 320 


Gly Leu Val Gln Ile Ala Pro Asn Leu Thr Val Ile Gln Phe Ile Lys 
                325                 330                 335     


Val Phe Pro Arg Val Leu Leu Gln Thr Leu Arg His Pro Ile Phe Leu 
            340                 345                 350         


Leu Val Val Leu Ser Gln Val Cys Leu Ser Ser Met Ala Ala Gly Met 
        355                 360                 365             


Ala Ile Phe Leu Pro Lys Phe Leu Glu Arg Gln Phe Ser Ile Thr Ala 
    370                 375                 380                 


Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu Ser Phe Pro Ser Val Ile 
385                 390                 395                 400 


Val Gly Ile Val Val Gly Gly Val Leu Val Lys Arg Leu His Leu Gly 
                405                 410                 415     


Pro Val Gly Cys Gly Ala Leu Cys Leu Leu Gly Met Leu Leu Cys Leu 
            420                 425                 430         


Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly Cys Ser Ser His Gln Ile 
        435                 440                 445             


Ala Gly Ile Thr His Gln Thr Ser Ala His Pro Gly Leu Glu Leu Ser 
    450                 455                 460                 


Pro Ser Cys Met Glu Ala Cys Ser Cys Pro Leu Asp Gly Phe Asn Pro 
465                 470                 475                 480 


Val Cys Asp Pro Ser Thr Arg Val Glu Tyr Ile Thr Pro Cys His Ala 
                485                 490                 495     


Gly Cys Ser Ser Trp Val Val Gln Asp Ala Leu Asp Asn Ser Gln Val 
            500                 505                 510         


Phe Tyr Thr Asn Cys Ser Cys Val Val Glu Gly Asn Pro Val Leu Ala 
        515                 520                 525             


Gly Ser Cys Asp Ser Thr Cys Ser His Leu Val Val Pro Phe Leu Leu 
    530                 535                 540                 


Leu Val Ser Leu Gly Ser Ala Leu Ala Cys Leu Thr His Thr Pro Ser 
545                 550                 555                 560 


Phe Met Leu Ile Leu Arg Gly Val Lys Lys Glu Asp Lys Thr Leu Ala 
                565                 570                 575     


Val Gly Ile Gln Phe Met Phe Leu Arg Ile Leu Ala Trp Met Pro Ser 
            580                 585                 590         


Pro Val Ile His Gly Ser Ala Ile Asp Thr Thr Cys Val His Trp Ala 
        595                 600                 605             


Leu Ser Cys Gly Arg Arg Ala Val Cys Arg Tyr Tyr Asn Asn Asp Leu 
    610                 615                 620                 


Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe Phe Phe Lys Thr Gly Ser 
625                 630                 635                 640 


Val Ile Cys Phe Ala Leu Val Leu Ala Val Leu Arg Gln Gln Asp Lys 
                645                 650                 655     


Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser Pro Ala Val Glu Gln Gln 
            660                 665                 670         


Leu Leu Val Ser Gly Pro Gly Lys Lys Pro Glu Asp Ser Arg Val 
        675                 680                 685         


<210>  16
<211>  565
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Pro Arg Ile Glu Asp Met Pro Gln Asp Phe Lys Ala Ser Leu 
1               5                   10                  15      


Cys Leu Pro Thr Thr Ser Ala Pro Ala Ser Ala Pro Ser Asn Gly Asn 
            20                  25                  30          


Cys Ser Ser Tyr Thr Glu Thr Gln His Leu Ser Val Val Gly Ile Met 
        35                  40                  45              


Phe Val Ala Gln Thr Leu Leu Gly Val Gly Gly Val Pro Ile Gln Pro 
    50                  55                  60                  


Phe Gly Ile Ser Tyr Ile Asp Asp Phe Ala His Asn Ser Asn Ser Pro 
65                  70                  75                  80  


Leu Tyr Leu Gly Ile Leu Phe Ala Val Thr Met Met Gly Pro Gly Leu 
                85                  90                  95      


Ala Phe Gly Leu Gly Ser Leu Met Leu Arg Leu Tyr Val Asp Ile Asn 
            100                 105                 110         


Gln Met Pro Glu Gly Gly Ile Ser Leu Thr Ile Lys Asp Pro Arg Trp 
        115                 120                 125             


Val Gly Ala Trp Trp Leu Gly Phe Leu Ile Ala Ala Gly Ala Val Ala 
    130                 135                 140                 


Leu Ala Ala Ile Pro Tyr Phe Phe Phe Pro Lys Glu Met Pro Lys Glu 
145                 150                 155                 160 


Lys Arg Glu Leu Gln Phe Arg Arg Lys Val Leu Ala Val Thr Asp Ser 
                165                 170                 175     


Pro Ala Arg Lys Gly Lys Asp Ser Pro Ser Lys Gln Ser Pro Gly Glu 
            180                 185                 190         


Ser Thr Lys Lys Gln Asp Gly Leu Val Gln Ile Ala Pro Asn Leu Thr 
        195                 200                 205             


Val Ile Gln Phe Ile Lys Val Phe Pro Arg Val Leu Leu Gln Thr Leu 
    210                 215                 220                 


Arg His Pro Ile Phe Leu Leu Val Val Leu Ser Gln Val Cys Leu Ser 
225                 230                 235                 240 


Ser Met Ala Ala Gly Met Ala Ile Phe Leu Pro Lys Phe Leu Glu Arg 
                245                 250                 255     


Gln Phe Ser Ile Thr Ala Ser Tyr Ala Asn Leu Leu Ile Gly Cys Leu 
            260                 265                 270         


Ser Phe Pro Ser Val Ile Val Gly Ile Val Val Gly Gly Val Leu Val 
        275                 280                 285             


Lys Arg Leu His Leu Gly Pro Val Gly Cys Gly Ala Leu Cys Leu Leu 
    290                 295                 300                 


Gly Met Leu Leu Cys Leu Phe Phe Ser Leu Pro Leu Phe Phe Ile Gly 
305                 310                 315                 320 


Cys Ser Ser His Gln Ile Ala Gly Ile Thr His Gln Thr Ser Ala His 
                325                 330                 335     


Pro Gly Leu Glu Leu Ser Pro Ser Cys Met Glu Ala Cys Ser Cys Pro 
            340                 345                 350         


Leu Asp Gly Phe Asn Pro Val Cys Asp Pro Ser Thr Arg Val Glu Tyr 
        355                 360                 365             


Ile Thr Pro Cys His Ala Gly Cys Ser Ser Trp Val Val Gln Asp Ala 
    370                 375                 380                 


Leu Asp Asn Ser Gln Val Phe Tyr Thr Asn Cys Ser Cys Val Val Glu 
385                 390                 395                 400 


Gly Asn Pro Val Leu Ala Gly Ser Cys Asp Ser Thr Cys Ser His Leu 
                405                 410                 415     


Val Val Pro Phe Leu Leu Leu Val Ser Leu Gly Ser Ala Leu Ala Cys 
            420                 425                 430         


Leu Thr His Thr Pro Ser Phe Met Leu Ile Leu Arg Gly Val Lys Lys 
        435                 440                 445             


Glu Asp Lys Thr Leu Ala Val Gly Ile Gln Phe Met Phe Leu Arg Ile 
    450                 455                 460                 


Leu Ala Trp Met Pro Ser Pro Val Ile His Gly Ser Ala Ile Asp Thr 
465                 470                 475                 480 


Thr Cys Val His Trp Ala Leu Ser Cys Gly Arg Arg Ala Val Cys Arg 
                485                 490                 495     


Tyr Tyr Asn Asn Asp Leu Leu Arg Asn Arg Phe Ile Gly Leu Gln Phe 
            500                 505                 510         


Phe Phe Lys Thr Gly Ser Val Ile Cys Phe Ala Leu Val Leu Ala Val 
        515                 520                 525             


Leu Arg Gln Gln Asp Lys Glu Ala Arg Thr Lys Glu Ser Arg Ser Ser 
    530                 535                 540                 


Pro Ala Val Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys Lys Pro 
545                 550                 555                 560 


Glu Asp Ser Arg Val 
                565 


<210>  17
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Ser Phe Ser Ala Glu Thr Asn Ser Thr Asp Leu Leu Ser Gln 
1               5                   10                  15      


Pro Trp Asn Glu Pro Pro Val Ile Leu Ser Met Val Ile Leu Ser Leu 
            20                  25                  30          


Thr Phe Leu Leu Gly Leu Pro Gly Asn Gly Leu Val Leu Trp Val Ala 
        35                  40                  45              


Gly Leu Lys Met Gln Arg Thr Val Asn Thr Ile Trp Phe Leu His Leu 
    50                  55                  60                  


Thr Leu Ala Asp Leu Leu Cys Cys Leu Ser Leu Pro Phe Ser Leu Ala 
65                  70                  75                  80  


His Leu Ala Leu Gln Gly Gln Trp Pro Tyr Gly Arg Phe Leu Cys Lys 
                85                  90                  95      


Leu Ile Pro Ser Ile Ile Val Leu Asn Met Phe Ala Ser Val Phe Leu 
            100                 105                 110         


Leu Thr Ala Ile Ser Leu Asp Arg Cys Leu Val Val Phe Lys Pro Ile 
        115                 120                 125             


Trp Cys Gln Asn His Arg Asn Val Gly Met Ala Cys Ser Ile Cys Gly 
    130                 135                 140                 


Cys Ile Trp Val Val Ala Phe Val Met Cys Ile Pro Val Phe Val Tyr 
145                 150                 155                 160 


Arg Glu Ile Phe Thr Thr Asp Asn His Asn Arg Cys Gly Tyr Lys Phe 
                165                 170                 175     


Gly Leu Ser Ser Ser Leu Asp Tyr Pro Asp Phe Tyr Gly Asp Pro Leu 
            180                 185                 190         


Glu Asn Arg Ser Leu Glu Asn Ile Val Gln Pro Pro Gly Glu Met Asn 
        195                 200                 205             


Asp Arg Leu Asp Pro Ser Ser Phe Gln Thr Asn Asp His Pro Trp Thr 
    210                 215                 220                 


Val Pro Thr Val Phe Gln Pro Gln Thr Phe Gln Arg Pro Ser Ala Asp 
225                 230                 235                 240 


Ser Leu Pro Arg Gly Ser Ala Arg Leu Thr Ser Gln Asn Leu Tyr Ser 
                245                 250                 255     


Asn Val Phe Lys Pro Ala Asp Val Val Ser Pro Lys Ile Pro Ser Gly 
            260                 265                 270         


Phe Pro Ile Glu Asp His Glu Thr Ser Pro Leu Asp Asn Ser Asp Ala 
        275                 280                 285             


Phe Leu Ser Thr His Leu Lys Leu Phe Pro Ser Ala Ser Ser Asn Ser 
    290                 295                 300                 


Phe Tyr Glu Ser Glu Leu Pro Gln Gly Phe Gln Asp Tyr Tyr Asn Leu 
305                 310                 315                 320 


Gly Gln Phe Thr Asp Asp Asp Gln Val Pro Thr Pro Leu Val Ala Ile 
                325                 330                 335     


Thr Ile Thr Arg Leu Val Val Gly Phe Leu Leu Pro Ser Val Ile Met 
            340                 345                 350         


Ile Ala Cys Tyr Ser Phe Ile Val Phe Arg Met Gln Arg Gly Arg Phe 
        355                 360                 365             


Ala Lys Ser Gln Ser Lys Thr Phe Arg Val Ala Val Val Val Val Ala 
    370                 375                 380                 


Val Phe Leu Val Cys Trp Thr Pro Tyr His Ile Phe Gly Val Leu Ser 
385                 390                 395                 400 


Leu Leu Thr Asp Pro Glu Thr Pro Leu Gly Lys Thr Leu Met Ser Trp 
                405                 410                 415     


Asp His Val Cys Ile Ala Leu Ala Ser Ala Asn Ser Cys Phe Asn Pro 
            420                 425                 430         


Phe Leu Tyr Ala Leu Leu Gly Lys Asp Phe Arg Lys Lys Ala Arg Gln 
        435                 440                 445             


Ser Ile Gln Gly Ile Leu Glu Ala Ala Phe Ser Glu Glu Leu Thr Arg 
    450                 455                 460                 


Ser Thr His Cys Pro Ser Asn Asn Val Ile Ser Glu Arg Asn Ser Thr 
465                 470                 475                 480 


Thr Val 
        


<210>  18
<211>  1156
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Glu  Asn Ser His Glu Ser  Ala Asp Phe Ser Ala  Ala Glu Leu 
    1115                 1120                 1125             


Ile Ser  Val Ser Lys Phe Leu  Pro Ile Ser Gly Met  Glu Lys Glu 
    1130                 1135                 1140             


Ala Ile  Leu Ser His Thr Glu  Lys Glu Asn Gly Asn  Leu 
    1145                 1150                 1155     


<210>  19
<211>  1161
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Gly  Leu Trp Val Leu Gly  Gly Ser Ile Ala Gln  Gly Phe Arg 
    1115                 1120                 1125             


Ser Val  Ala Ala Val Glu Ala  Gln Thr Phe Tyr Phe  Asp Lys Gln 
    1130                 1135                 1140             


Leu Lys  Lys Ser Lys Asn Val  Ile Gly Ser Leu Asp  Ala Tyr Asn 
    1145                 1150                 1155             


Gly Gln  Glu 
    1160     


<210>  20
<211>  1121
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Arg Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro Cys 
            580                 585                 590         


Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu Cys 
        595                 600                 605             


Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln Leu 
    610                 615                 620                 


Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly Lys 
625                 630                 635                 640 


Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr Glu 
                645                 650                 655     


Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu Cys 
            660                 665                 670         


Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser Gln 
        675                 680                 685             


Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro Thr 
    690                 695                 700                 


Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu Arg 
705                 710                 715                 720 


Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr His 
                725                 730                 735     


Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser Asp 
            740                 745                 750         


Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn Ala 
        755                 760                 765             


Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu Asp 
    770                 775                 780                 


Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His Ser 
785                 790                 795                 800 


His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly Val 
                805                 810                 815     


Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser Arg 
            820                 825                 830         


Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp Gly 
        835                 840                 845             


Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val Cys 
    850                 855                 860                 


Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser Leu 
865                 870                 875                 880 


Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys Pro 
                885                 890                 895     


Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu Lys 
            900                 905                 910         


Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn Lys 
        915                 920                 925             


Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu Ile 
    930                 935                 940                 


Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp Leu 
945                 950                 955                 960 


Asp Asp Ala Gln Val Val Cys Gln Gln Leu Gly Cys Gly Pro Ala Leu 
                965                 970                 975     


Lys Ala Phe Lys Glu Ala Glu Phe Gly Gln Gly Thr Gly Pro Ile Trp 
            980                 985                 990         


Leu Asn Glu Val Lys Cys Lys Gly  Asn Glu Ser Ser Leu  Trp Asp Cys 
        995                 1000                 1005             


Pro Ala  Arg Arg Trp Gly His  Ser Glu Cys Gly His  Lys Glu Asp 
    1010                 1015                 1020             


Ala Ala  Val Asn Cys Thr Asp  Ile Ser Val Gln Lys  Thr Pro Gln 
    1025                 1030                 1035             


Lys Ala  Thr Thr Gly Arg Ser  Ser Arg Gln Ser Ser  Phe Ile Ala 
    1040                 1045                 1050             


Val Gly  Ile Leu Gly Val Val  Leu Leu Ala Ile Phe  Val Ala Leu 
    1055                 1060                 1065             


Phe Phe  Leu Thr Lys Lys Arg  Arg Gln Arg Gln Arg  Leu Ala Val 
    1070                 1075                 1080             


Ser Ser  Arg Gly Glu Asn Leu  Val His Gln Ile Gln  Tyr Arg Glu 
    1085                 1090                 1095             


Met Asn  Ser Cys Leu Asn Ala  Asp Asp Leu Asp Leu  Met Asn Ser 
    1100                 1105                 1110             


Ser Gly  Gly His Ser Glu Pro  His 
    1115                 1120     


<210>  21
<211>  1154
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Lys Leu Arg Met Val Leu Leu Glu Asp Ser Gly Ser Ala Asp 
1               5                   10                  15      


Phe Arg Arg His Phe Val Asn Leu Ser Pro Phe Thr Ile Thr Val Val 
            20                  25                  30          


Leu Leu Leu Ser Ala Cys Phe Val Thr Ser Ser Leu Gly Gly Thr Asp 
        35                  40                  45              


Lys Glu Leu Arg Leu Val Asp Gly Glu Asn Lys Cys Ser Gly Arg Val 
    50                  55                  60                  


Glu Val Lys Val Gln Glu Glu Trp Gly Thr Val Cys Asn Asn Gly Trp 
65                  70                  75                  80  


Ser Met Glu Ala Val Ser Val Ile Cys Asn Gln Leu Gly Cys Pro Thr 
                85                  90                  95      


Ala Ile Lys Ala Pro Gly Trp Ala Asn Ser Ser Ala Gly Ser Gly Arg 
            100                 105                 110         


Ile Trp Met Asp His Val Ser Cys Arg Gly Asn Glu Ser Ala Leu Trp 
        115                 120                 125             


Asp Cys Lys His Asp Gly Trp Gly Lys His Ser Asn Cys Thr His Gln 
    130                 135                 140                 


Gln Asp Ala Gly Val Thr Cys Ser Asp Gly Ser Asn Leu Glu Met Arg 
145                 150                 155                 160 


Leu Thr Arg Gly Gly Asn Met Cys Ser Gly Arg Ile Glu Ile Lys Phe 
                165                 170                 175     


Gln Gly Arg Trp Gly Thr Val Cys Asp Asp Asn Phe Asn Ile Asp His 
            180                 185                 190         


Ala Ser Val Ile Cys Arg Gln Leu Glu Cys Gly Ser Ala Val Ser Phe 
        195                 200                 205             


Ser Gly Ser Ser Asn Phe Gly Glu Gly Ser Gly Pro Ile Trp Phe Asp 
    210                 215                 220                 


Asp Leu Ile Cys Asn Gly Asn Glu Ser Ala Leu Trp Asn Cys Lys His 
225                 230                 235                 240 


Gln Gly Trp Gly Lys His Asn Cys Asp His Ala Glu Asp Ala Gly Val 
                245                 250                 255     


Ile Cys Ser Lys Gly Ala Asp Leu Ser Leu Arg Leu Val Asp Gly Val 
            260                 265                 270         


Thr Glu Cys Ser Gly Arg Leu Glu Val Arg Phe Gln Gly Glu Trp Gly 
        275                 280                 285             


Thr Ile Cys Asp Asp Gly Trp Asp Ser Tyr Asp Ala Ala Val Ala Cys 
    290                 295                 300                 


Lys Gln Leu Gly Cys Pro Thr Ala Val Thr Ala Ile Gly Arg Val Asn 
305                 310                 315                 320 


Ala Ser Lys Gly Phe Gly His Ile Trp Leu Asp Ser Val Ser Cys Gln 
                325                 330                 335     


Gly His Glu Pro Ala Ile Trp Gln Cys Lys His His Glu Trp Gly Lys 
            340                 345                 350         


His Tyr Cys Asn His Asn Glu Asp Ala Gly Val Thr Cys Ser Asp Gly 
        355                 360                 365             


Ser Asp Leu Glu Leu Arg Leu Arg Gly Gly Gly Ser Arg Cys Ala Gly 
    370                 375                 380                 


Thr Val Glu Val Glu Ile Gln Arg Leu Leu Gly Lys Val Cys Asp Arg 
385                 390                 395                 400 


Gly Trp Gly Leu Lys Glu Ala Asp Val Val Cys Arg Gln Leu Gly Cys 
                405                 410                 415     


Gly Ser Ala Leu Lys Thr Ser Tyr Gln Val Tyr Ser Lys Ile Gln Ala 
            420                 425                 430         


Thr Asn Thr Trp Leu Phe Leu Ser Ser Cys Asn Gly Asn Glu Thr Ser 
        435                 440                 445             


Leu Trp Asp Cys Lys Asn Trp Gln Trp Gly Gly Leu Thr Cys Asp His 
    450                 455                 460                 


Tyr Glu Glu Ala Lys Ile Thr Cys Ser Ala His Arg Glu Pro Arg Leu 
465                 470                 475                 480 


Val Gly Gly Asp Ile Pro Cys Ser Gly Arg Val Glu Val Lys His Gly 
                485                 490                 495     


Asp Thr Trp Gly Ser Ile Cys Asp Ser Asp Phe Ser Leu Glu Ala Ala 
            500                 505                 510         


Ser Val Leu Cys Arg Glu Leu Gln Cys Gly Thr Val Val Ser Ile Leu 
        515                 520                 525             


Gly Gly Ala His Phe Gly Glu Gly Asn Gly Gln Ile Trp Ala Glu Glu 
    530                 535                 540                 


Phe Gln Cys Glu Gly His Glu Ser His Leu Ser Leu Cys Pro Val Ala 
545                 550                 555                 560 


Pro Arg Pro Glu Gly Thr Cys Ser His Ser Arg Asp Val Gly Val Val 
                565                 570                 575     


Cys Ser Ser Lys Thr Gln Lys Thr Ser Leu Ile Gly Ser Tyr Thr Val 
            580                 585                 590         


Lys Gly Thr Gly Leu Gly Ser His Ser Cys Leu Phe Leu Lys Pro Cys 
        595                 600                 605             


Leu Leu Pro Gly Tyr Thr Glu Ile Arg Leu Val Asn Gly Lys Thr Pro 
    610                 615                 620                 


Cys Glu Gly Arg Val Glu Leu Lys Thr Leu Gly Ala Trp Gly Ser Leu 
625                 630                 635                 640 


Cys Asn Ser His Trp Asp Ile Glu Asp Ala His Val Leu Cys Gln Gln 
                645                 650                 655     


Leu Lys Cys Gly Val Ala Leu Ser Thr Pro Gly Gly Ala Arg Phe Gly 
            660                 665                 670         


Lys Gly Asn Gly Gln Ile Trp Arg His Met Phe His Cys Thr Gly Thr 
        675                 680                 685             


Glu Gln His Met Gly Asp Cys Pro Val Thr Ala Leu Gly Ala Ser Leu 
    690                 695                 700                 


Cys Pro Ser Glu Gln Val Ala Ser Val Ile Cys Ser Gly Asn Gln Ser 
705                 710                 715                 720 


Gln Thr Leu Ser Ser Cys Asn Ser Ser Ser Leu Gly Pro Thr Arg Pro 
                725                 730                 735     


Thr Ile Pro Glu Glu Ser Ala Val Ala Cys Ile Glu Ser Gly Gln Leu 
            740                 745                 750         


Arg Leu Val Asn Gly Gly Gly Arg Cys Ala Gly Arg Val Glu Ile Tyr 
        755                 760                 765             


His Glu Gly Ser Trp Gly Thr Ile Cys Asp Asp Ser Trp Asp Leu Ser 
    770                 775                 780                 


Asp Ala His Val Val Cys Arg Gln Leu Gly Cys Gly Glu Ala Ile Asn 
785                 790                 795                 800 


Ala Thr Gly Ser Ala His Phe Gly Glu Gly Thr Gly Pro Ile Trp Leu 
                805                 810                 815     


Asp Glu Met Lys Cys Asn Gly Lys Glu Ser Arg Ile Trp Gln Cys His 
            820                 825                 830         


Ser His Gly Trp Gly Gln Gln Asn Cys Arg His Lys Glu Asp Ala Gly 
        835                 840                 845             


Val Ile Cys Ser Glu Phe Met Ser Leu Arg Leu Thr Ser Glu Ala Ser 
    850                 855                 860                 


Arg Glu Ala Cys Ala Gly Arg Leu Glu Val Phe Tyr Asn Gly Ala Trp 
865                 870                 875                 880 


Gly Thr Val Gly Lys Ser Ser Met Ser Glu Thr Thr Val Gly Val Val 
                885                 890                 895     


Cys Arg Gln Leu Gly Cys Ala Asp Lys Gly Lys Ile Asn Pro Ala Ser 
            900                 905                 910         


Leu Asp Lys Ala Met Ser Ile Pro Met Trp Val Asp Asn Val Gln Cys 
        915                 920                 925             


Pro Lys Gly Pro Asp Thr Leu Trp Gln Cys Pro Ser Ser Pro Trp Glu 
    930                 935                 940                 


Lys Arg Leu Ala Ser Pro Ser Glu Glu Thr Trp Ile Thr Cys Asp Asn 
945                 950                 955                 960 


Lys Ile Arg Leu Gln Glu Gly Pro Thr Ser Cys Ser Gly Arg Val Glu 
                965                 970                 975     


Ile Trp His Gly Gly Ser Trp Gly Thr Val Cys Asp Asp Ser Trp Asp 
            980                 985                 990         


Leu Asp Asp Ala Gln Val Val Cys  Gln Gln Leu Gly Cys  Gly Pro Ala 
        995                 1000                 1005             


Leu Lys  Ala Phe Lys Glu Ala  Glu Phe Gly Gln Gly  Thr Gly Pro 
    1010                 1015                 1020             


Ile Trp  Leu Asn Glu Val Lys  Cys Lys Gly Asn Glu  Ser Ser Leu 
    1025                 1030                 1035             


Trp Asp  Cys Pro Ala Arg Arg  Trp Gly His Ser Glu  Cys Gly His 
    1040                 1045                 1050             


Lys Glu  Asp Ala Ala Val Asn  Cys Thr Asp Ile Ser  Val Gln Lys 
    1055                 1060                 1065             


Thr Pro  Gln Lys Ala Thr Thr  Gly Arg Ser Ser Arg  Gln Ser Ser 
    1070                 1075                 1080             


Phe Ile  Ala Val Gly Ile Leu  Gly Val Val Leu Leu  Ala Ile Phe 
    1085                 1090                 1095             


Val Ala  Leu Phe Phe Leu Thr  Lys Lys Arg Arg Gln  Arg Gln Arg 
    1100                 1105                 1110             


Leu Ala  Val Ser Ser Arg Gly  Glu Asn Leu Val His  Gln Ile Gln 
    1115                 1120                 1125             


Tyr Arg  Glu Met Asn Ser Cys  Leu Asn Ala Asp Asp  Leu Asp Leu 
    1130                 1135                 1140             


Met Asn  Ser Ser Gly Gly His  Ser Glu Pro His 
    1145                 1150                 


<210>  22
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu Leu Pro 
145                 150                 155                 160 


Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser Leu Leu 
                165                 170                 175     


Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly Met Ser Pro 
            180                 185                 190         


Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr Ala Asp Leu 
        195                 200                 205             


Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr Thr Lys Leu 
    210                 215                 220                 


Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val Thr Met Ala 
225                 230                 235                 240 


Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr Leu Gly Ala 
                245                 250                 255     


Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu Ser Ser His 
            260                 265                 270         


Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser Thr Ile Ser 
        275                 280                 285             


Arg Pro 
    290 


<210>  23
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Ser Thr Pro Ala Pro Thr Thr Pro Thr Ser Thr Thr Phe 
    130                 135                 140                 


Thr Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr 
145                 150                 155                 160 


Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val Leu 
                165                 170                 175     


Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala Ser 
            180                 185                 190         


Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Gly Thr Ala Ala 
        195                 200                 205             


Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala Ala Gly Arg 
    210                 215                 220                 


Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys Pro Gly 
225                 230                 235                 


<210>  24
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Arg Tyr Cys Ser Pro Trp Arg Ala Thr 
145                 150                 155                 160 


Ser Ala Met Gln Thr 
                165 


<210>  25
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Ser Ser Arg Asp Val Pro Arg Ala Gly 
145                 150                 155                 160 


Thr Ala Ala Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp Pro Ala 
                165                 170                 175     


Ala Gly Arg Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe Leu Cys 
            180                 185                 190         


Pro Gly 
        


<210>  26
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Pro Leu Leu Thr Leu Tyr Leu Leu Leu Phe Trp Leu Ser Gly Tyr 
1               5                   10                  15      


Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn Gly Leu Glu 
            20                  25                  30          


Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly Trp Glu Thr 
        35                  40                  45              


Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp Cys Lys Ile 
    50                  55                  60                  


Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg Asp Arg Val 
65                  70                  75                  80  


Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val Thr Met Glu 
                85                  90                  95      


Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly Ile Glu Lys 
            100                 105                 110         


Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile Asp Pro Ala 
        115                 120                 125             


Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu Thr Gly His 
    130                 135                 140                 


His Leu Asp Asn Arg Ser Glu Gly Ser Gln Ala Ala Asn Tyr Arg Pro 
145                 150                 155                 160 


Ala Ala His Gln Ala Gln Ala Pro Glu Ala Gln Cys Pro Pro Ala Pro 
                165                 170                 175     


His Leu His His Ile Ala Ala Ala Phe Gly Gly Arg Leu Thr Leu Gly 
            180                 185                 190         


Leu Glu Asp Asp Glu Val Pro Ala Glu Ser Ser Arg Asp Val Pro Arg 
        195                 200                 205             


Ala Gly Thr Ala Ala Pro Gly Gly Arg Pro Leu Leu Cys Arg Pro Asp 
    210                 215                 220                 


Pro Ala Ala Gly Arg Asn Leu Pro Ala Lys Gly Tyr His Glu Ala Phe 
225                 230                 235                 240 


Leu Cys Pro Gly 
                


<210>  27
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Trp Leu Pro Gln Leu Asp Leu Met Arg Val Ile Ser Ala Lys Ser 
1               5                   10                  15      


Gln Gly Tyr Ser Ile Val Thr Gln Ile Thr Gly Pro Thr Thr Val Asn 
            20                  25                  30          


Gly Leu Glu Arg Gly Ser Leu Thr Val Gln Cys Val Tyr Arg Ser Gly 
        35                  40                  45              


Trp Glu Thr Tyr Leu Lys Trp Trp Cys Arg Gly Ala Ile Trp Arg Asp 
    50                  55                  60                  


Cys Lys Ile Leu Val Lys Thr Ser Gly Ser Glu Gln Glu Val Lys Arg 
65                  70                  75                  80  


Asp Arg Val Ser Ile Lys Asp Asn Gln Lys Asn Arg Thr Phe Thr Val 
                85                  90                  95      


Thr Met Glu Asp Leu Met Lys Thr Asp Ala Asp Thr Tyr Trp Cys Gly 
            100                 105                 110         


Ile Glu Lys Thr Gly Asn Asp Leu Gly Val Thr Val Gln Val Thr Ile 
        115                 120                 125             


Asp Pro Ala Pro Val Thr Gln Glu Glu Thr Ser Ser Ser Pro Thr Leu 
    130                 135                 140                 


Thr Gly His His Leu Asp Asn Arg His Lys Leu Leu Lys Leu Ser Val 
145                 150                 155                 160 


Leu Leu Pro Leu Ile Phe Thr Ile Leu Leu Leu Leu Leu Val Ala Ala 
                165                 170                 175     


Ser Leu Leu Ala Trp Arg Met Met Lys Tyr Gln Gln Lys Ala Ala Gly 
            180                 185                 190         


Met Ser Pro Glu Gln Val Leu Gln Pro Leu Glu Gly Asp Leu Cys Tyr 
        195                 200                 205             


Ala Asp Leu Thr Leu Gln Leu Ala Gly Thr Ser Pro Gln Lys Ala Thr 
    210                 215                 220                 


Thr Lys Leu Ser Ser Ala Gln Val Asp Gln Val Glu Val Glu Tyr Val 
225                 230                 235                 240 


Thr Met Ala Ser Leu Pro Lys Glu Asp Ile Ser Tyr Ala Ser Leu Thr 
                245                 250                 255     


Leu Gly Ala Glu Asp Gln Glu Pro Thr Tyr Cys Asn Met Gly His Leu 
            260                 265                 270         


Ser Ser His Leu Pro Gly Arg Gly Pro Glu Glu Pro Thr Glu Tyr Ser 
        275                 280                 285             


Thr Ile Ser Arg Pro 
    290             


<210>  28
<211>  1231
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro  Met Gly Glu Lys Lys  Asp Val Tyr 
        995                 1000                 1005             


Lys Ala  Gly Glu Gln Val Thr  Tyr Thr Cys Ala Thr  Tyr Tyr Lys 
    1010                 1015                 1020             


Met Asp  Gly Ala Ser Asn Val  Thr Cys Ile Asn Ser  Arg Trp Thr 
    1025                 1030                 1035             


Gly Arg  Pro Thr Cys Arg Asp  Thr Ser Cys Val Asn  Pro Pro Thr 
    1040                 1045                 1050             


Val Gln  Asn Ala Tyr Ile Val  Ser Arg Gln Met Ser  Lys Tyr Pro 
    1055                 1060                 1065             


Ser Gly  Glu Arg Val Arg Tyr  Gln Cys Arg Ser Pro  Tyr Glu Met 
    1070                 1075                 1080             


Phe Gly  Asp Glu Glu Val Met  Cys Leu Asn Gly Asn  Trp Thr Glu 
    1085                 1090                 1095             


Pro Pro  Gln Cys Lys Asp Ser  Thr Gly Lys Cys Gly  Pro Pro Pro 
    1100                 1105                 1110             


Pro Ile  Asp Asn Gly Asp Ile  Thr Ser Phe Pro Leu  Ser Val Tyr 
    1115                 1120                 1125             


Ala Pro  Ala Ser Ser Val Glu  Tyr Gln Cys Gln Asn  Leu Tyr Gln 
    1130                 1135                 1140             


Leu Glu  Gly Asn Lys Arg Ile  Thr Cys Arg Asn Gly  Gln Trp Ser 
    1145                 1150                 1155             


Glu Pro  Pro Lys Cys Leu His  Pro Cys Val Ile Ser  Arg Glu Ile 
    1160                 1165                 1170             


Met Glu  Asn Tyr Asn Ile Ala  Leu Arg Trp Thr Ala  Lys Gln Lys 
    1175                 1180                 1185             


Leu Tyr  Ser Arg Thr Gly Glu  Ser Val Glu Phe Val  Cys Lys Arg 
    1190                 1195                 1200             


Gly Tyr  Arg Leu Ser Ser Arg  Ser His Thr Leu Arg  Thr Thr Cys 
    1205                 1210                 1215             


Trp Asp  Gly Lys Leu Glu Tyr  Pro Thr Cys Ala Lys  Arg 
    1220                 1225                 1230     


<210>  29
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Ser Phe Thr 
        435                 440                 445             


Leu 
    


<210>  30
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Glu Met Cys Ile 
        275                 280                 285             


Glu Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu 
    290                 295                 300                 


Glu Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala 
305                 310                 315                 320 


Asn Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg 
                325                 330                 335     


Gly Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val 
            340                 345                 350         


Leu Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu 
        355                 360                 365             


Asn Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro 
    370                 375                 380                 


Val Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp 
385                 390                 395                 400 


Ala Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly 
                405                 410                 415     


Phe Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp 
            420                 425                 430         


Phe Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly 
        435                 440                 445             


Glu Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val 
    450                 455                 460                 


Val Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg 
465                 470                 475                 480 


Cys Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser 
                485                 490                 495     


Lys Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe 
            500                 505                 510         


Arg His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser 
        515                 520                 525             


Ser Lys Lys Thr 
    530         


<210>  31
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Glu Ser Tyr Ser Val Thr Gln Ala Gly Val Gln Trp His Glu Leu 
1               5                   10                  15      


Cys Ser Leu Gln Pro Ser Pro Pro Arg Phe Arg Glu Met Cys Ile Glu 
            20                  25                  30          


Gln Asp Gly Arg Val His Leu Thr Val Val Tyr Phe Gly Lys Glu Glu 
        35                  40                  45              


Ile Asn Glu Val Lys Gly Ile Leu Glu Asn Thr Ser Lys Ala Ala Asn 
    50                  55                  60                  


Phe Arg Asn Phe Thr Phe Ile Gln Leu Asn Gly Glu Phe Ser Arg Gly 
65                  70                  75                  80  


Lys Gly Leu Asp Val Gly Ala Arg Phe Trp Lys Gly Ser Asn Val Leu 
                85                  90                  95      


Leu Phe Phe Cys Asp Val Asp Ile Tyr Phe Thr Ser Glu Phe Leu Asn 
            100                 105                 110         


Thr Cys Arg Leu Asn Thr Gln Pro Gly Lys Lys Val Phe Tyr Pro Val 
        115                 120                 125             


Leu Phe Ser Gln Tyr Asn Pro Gly Ile Ile Tyr Gly His His Asp Ala 
    130                 135                 140                 


Val Pro Pro Leu Glu Gln Gln Leu Val Ile Lys Lys Glu Thr Gly Phe 
145                 150                 155                 160 


Trp Arg Asp Phe Gly Phe Gly Met Thr Cys Gln Tyr Arg Ser Asp Phe 
                165                 170                 175     


Ile Asn Ile Gly Gly Phe Asp Leu Asp Ile Lys Gly Trp Gly Gly Glu 
            180                 185                 190         


Asp Val His Leu Tyr Arg Lys Tyr Leu His Ser Asn Leu Ile Val Val 
        195                 200                 205             


Arg Thr Pro Val Arg Gly Leu Phe His Leu Trp His Glu Lys Arg Cys 
    210                 215                 220                 


Met Asp Glu Leu Thr Pro Glu Gln Tyr Lys Met Cys Met Gln Ser Lys 
225                 230                 235                 240 


Ala Met Asn Glu Ala Ser His Gly Gln Leu Gly Met Leu Val Phe Arg 
                245                 250                 255     


His Glu Ile Glu Ala His Leu Arg Lys Gln Lys Gln Lys Thr Ser Ser 
            260                 265                 270         


Lys Lys Thr 
        275 


<210>  32
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Met Met Val Arg Arg Gly Leu Leu Ala Trp Ile Ser Arg Val Val 
1               5                   10                  15      


Val Leu Leu Val Leu Leu Cys Cys Ala Ile Ser Val Leu Tyr Met Leu 
            20                  25                  30          


Ala Cys Thr Pro Lys Gly Asp Glu Glu Gln Leu Ala Leu Pro Arg Ala 
        35                  40                  45              


Asn Ser Pro Thr Gly Lys Glu Gly Tyr Gln Ala Val Leu Gln Glu Trp 
    50                  55                  60                  


Glu Glu Gln His Arg Asn Tyr Val Ser Ser Leu Lys Arg Gln Ile Ala 
65                  70                  75                  80  


Gln Leu Lys Glu Glu Leu Gln Glu Arg Ser Glu Gln Leu Arg Asn Gly 
                85                  90                  95      


Gln Tyr Gln Ala Ser Asp Ala Ala Gly Leu Gly Leu Asp Arg Ser Pro 
            100                 105                 110         


Pro Glu Lys Thr Gln Ala Asp Leu Leu Ala Phe Leu His Ser Gln Val 
        115                 120                 125             


Asp Lys Ala Glu Val Asn Ala Gly Val Lys Leu Ala Thr Glu Tyr Ala 
    130                 135                 140                 


Ala Val Pro Phe Asp Ser Phe Thr Leu Gln Lys Val Tyr Gln Leu Glu 
145                 150                 155                 160 


Thr Gly Leu Thr Arg His Pro Glu Glu Lys Pro Val Arg Lys Asp Lys 
                165                 170                 175     


Arg Asp Glu Leu Val Glu Ala Ile Glu Ser Ala Leu Glu Thr Leu Asn 
            180                 185                 190         


Ser Pro Ala Glu Asn Ser Pro Asn His Arg Pro Tyr Thr Ala Ser Asp 
        195                 200                 205             


Phe Ile Glu Gly Ile Tyr Arg Thr Glu Arg Asp Lys Gly Thr Leu Tyr 
    210                 215                 220                 


Glu Leu Thr Phe Lys Gly Asp His Lys His Glu Phe Lys Arg Leu Ile 
225                 230                 235                 240 


Leu Phe Arg Pro Phe Gly Pro Ile Met Lys Val Lys Asn Glu Lys Leu 
                245                 250                 255     


Asn Met Ala Asn Thr Leu Ile Asn Val Ile Val Pro Leu Ala Lys Arg 
            260                 265                 270         


Val Asp Lys Phe Arg Gln Phe Met Gln Asn Phe Arg Pro Ala Asp Glu 
        275                 280                 285             


Val Phe Arg Cys Val Pro Leu Ser Pro 
    290                 295         


<210>  33
<211>  338
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Ile Asn Ser Thr Ser Thr Gln Pro Pro Asp Glu Ser Cys Ser Gln 
1               5                   10                  15      


Asn Leu Leu Ile Thr Gln Gln Ile Ile Pro Val Leu Tyr Cys Met Val 
            20                  25                  30          


Phe Ile Ala Gly Ile Leu Leu Asn Gly Val Ser Gly Trp Ile Phe Phe 
        35                  40                  45              


Tyr Val Pro Ser Ser Lys Ser Phe Ile Ile Tyr Leu Lys Asn Ile Val 
    50                  55                  60                  


Ile Ala Asp Phe Val Met Ser Leu Thr Phe Pro Phe Lys Ile Leu Gly 
65                  70                  75                  80  


Asp Ser Gly Leu Gly Pro Trp Gln Leu Asn Val Phe Val Cys Arg Val 
                85                  90                  95      


Ser Ala Val Leu Phe Tyr Val Asn Met Tyr Val Ser Ile Val Phe Phe 
            100                 105                 110         


Gly Leu Ile Ser Phe Asp Arg Tyr Tyr Lys Ile Val Lys Pro Leu Trp 
        115                 120                 125             


Thr Ser Phe Ile Gln Ser Val Ser Tyr Ser Lys Leu Leu Ser Val Ile 
    130                 135                 140                 


Val Trp Met Leu Met Leu Leu Leu Ala Val Pro Asn Ile Ile Leu Thr 
145                 150                 155                 160 


Asn Gln Ser Val Arg Glu Val Thr Gln Ile Lys Cys Ile Glu Leu Lys 
                165                 170                 175     


Ser Glu Leu Gly Arg Lys Trp His Lys Ala Ser Asn Tyr Ile Phe Val 
            180                 185                 190         


Ala Ile Phe Trp Ile Val Phe Leu Leu Leu Ile Val Phe Tyr Thr Ala 
        195                 200                 205             


Ile Thr Lys Lys Ile Phe Lys Ser His Leu Lys Ser Ser Arg Asn Ser 
    210                 215                 220                 


Thr Ser Val Lys Lys Lys Ser Ser Arg Asn Ile Phe Ser Ile Val Phe 
225                 230                 235                 240 


Val Phe Phe Val Cys Phe Val Pro Tyr His Ile Ala Arg Ile Pro Tyr 
                245                 250                 255     


Thr Lys Ser Gln Thr Glu Ala His Tyr Ser Cys Gln Ser Lys Glu Ile 
            260                 265                 270         


Leu Arg Tyr Met Lys Glu Phe Thr Leu Leu Leu Ser Ala Ala Asn Val 
        275                 280                 285             


Cys Leu Asp Pro Ile Ile Tyr Phe Phe Leu Cys Gln Pro Phe Arg Glu 
    290                 295                 300                 


Ile Leu Cys Lys Lys Leu His Ile Pro Leu Lys Ala Gln Asn Asp Leu 
305                 310                 315                 320 


Asp Ile Ser Arg Ile Lys Arg Gly Asn Thr Thr Leu Glu Ser Thr Asp 
                325                 330                 335     


Thr Leu 
        


<210>  34
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
1               5                   10                  15      


Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
            20                  25                  30          


Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
        35                  40                  45              


Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
    50                  55                  60                  


Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
65                  70                  75                  80  


Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                85                  90                  95      


Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
            100                 105                 110         


Tyr Leu Glu Glu Gln Cys Leu Lys Met Leu Glu Thr Ile Gln Ala Ser 
        115                 120                 125             


Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Asp Gly Gly Ala Glu Glu 
    130                 135                 140                 


Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
145                 150                 155                 160 


His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Gly Gln Ser Leu 
                165                 170                 175     


Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
            180                 185                 190         


Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
        195                 200                 205             


Ile Gly Gln Ser Leu Leu Gln Gly Thr Leu Gln Pro Pro Ala Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Gly Val Ala Glu 
225                 230                 235                 240 


Val Lys Thr Glu Met Met Gln Val Asp Glu Val Pro Ser Gln Asp Ser 
                245                 250                 255     


Pro Gly Ala Ala Glu Ser Ser Ile Ser Gly Gly Met Gly Asp Lys Val 
            260                 265                 270         


Glu Glu Arg Gly Lys Glu Gly Pro Gly Thr Pro Thr Arg Ser Ser Val 
        275                 280                 285             


Ile Thr Ser Ala Arg Glu Leu His Tyr Gly Arg Glu Glu Ser Ala Glu 
    290                 295                 300                 


Gln Val Pro Pro Pro Ala Glu Ala Gly Gln Ala Pro Thr Gly Arg Pro 
305                 310                 315                 320 


Glu His Pro Ala Pro Pro Pro Glu Lys His Leu Gly Ile Tyr Ser Val 
                325                 330                 335     


Leu Pro Asn His Lys Ala Asp Ala Val Leu Ser Met Pro Ser Ser Val 
            340                 345                 350         


Thr Ser Gly Leu His Val Gln Pro Ala Leu Ala Val Ser Met Asp Phe 
        355                 360                 365             


Ser Thr Tyr Gly Gly Leu Leu Pro Gln Gly Phe Ile Gln Arg Glu Leu 
    370                 375                 380                 


Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met Lys Ser Glu Ser Arg 
385                 390                 395                 400 


Thr Ile Gly Glu Gln Cys Ser Val Cys Gly Val Glu Leu Pro Asp Asn 
                405                 410                 415     


Glu Ala Val Glu Gln His Arg Lys Leu His Ser Gly Met Lys Thr Tyr 
            420                 425                 430         


Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp Ser Leu Arg Leu Arg 
        435                 440                 445             


Met His Leu Leu Ala His Ser Ala Gly Ala Lys Ala Phe Val Cys Asp 
    450                 455                 460                 


Gln Cys Gly Ala Gln Phe Ser Lys Glu Asp Ala Leu Glu Thr His Arg 
465                 470                 475                 480 


Gln Thr His Thr Gly Thr Asp Met Ala Val Phe Cys Leu Leu Cys Gly 
                485                 490                 495     


Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln His Met Glu Val His 
            500                 505                 510         


Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys Asn Arg Thr Phe Pro 
        515                 520                 525             


Ser His Thr Ala Leu Lys Arg His Leu Arg Ser His Thr Gly Asp His 
    530                 535                 540                 


Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Leu Lys Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                565                 570                 575     


Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His Gln Leu Glu Thr His 
            580                 585                 590         


Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Lys Leu Cys His 
        595                 600                 605             


Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys His Leu Arg Thr His 
    610                 615                 620                 


Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys Thr Glu Tyr Cys Pro 
625                 630                 635                 640 


Ser Leu Ser Ser Met Gln Lys His Met Lys Gly His Lys Pro Glu Glu 
                645                 650                 655     


Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr Leu Tyr Leu Cys Tyr 
            660                 665                 670         


Val 
    


<210>  35
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
1               5                   10                  15      


Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
            20                  25                  30          


Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
        35                  40                  45              


Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
    50                  55                  60                  


Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
65                  70                  75                  80  


Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                85                  90                  95      


Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
            100                 105                 110         


Tyr Leu Glu Glu Gln Cys Leu Lys Met Leu Glu Thr Ile Gln Ala Ser 
        115                 120                 125             


Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Asp Gly Gly Ala Glu Glu 
    130                 135                 140                 


Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
145                 150                 155                 160 


His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Gly Gln Ser Leu 
                165                 170                 175     


Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
            180                 185                 190         


Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
        195                 200                 205             


Ile Gly Gln Ser Leu Leu Gln Gly Thr Leu Gln Pro Pro Ala Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Gly Val Ala Glu 
225                 230                 235                 240 


Val Lys Thr Glu Met Met Gln Val Asp Glu Val Pro Ser Gln Gly Phe 
                245                 250                 255     


Ile Gln Arg Glu Leu Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met 
            260                 265                 270         


Lys Ser Glu Ser Arg Thr Ile Gly Glu Gln Cys Ser Val Cys Gly Val 
        275                 280                 285             


Glu Leu Pro Asp Asn Glu Ala Val Glu Gln His Arg Lys Leu His Ser 
    290                 295                 300                 


Gly Met Lys Thr Tyr Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp 
305                 310                 315                 320 


Ser Leu Arg Leu Arg Met His Leu Leu Ala His Ser Ala Gly Ala Lys 
                325                 330                 335     


Ala Phe Val Cys Asp Gln Cys Gly Ala Gln Phe Ser Lys Glu Asp Ala 
            340                 345                 350         


Leu Glu Thr His Arg Gln Thr His Thr Gly Thr Asp Met Ala Val Phe 
        355                 360                 365             


Cys Leu Leu Cys Gly Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln 
    370                 375                 380                 


His Met Glu Val His Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys 
385                 390                 395                 400 


Asn Arg Thr Phe Pro Ser His Thr Ala Leu Lys Arg His Leu Arg Ser 
                405                 410                 415     


His Thr Gly Asp His Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe 
            420                 425                 430         


Arg Asp Glu Ser Thr Leu Lys Ser His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Glu Cys Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His 
    450                 455                 460                 


Gln Leu Glu Thr His Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu 
465                 470                 475                 480 


Cys Lys Leu Cys His Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys 
                485                 490                 495     


His Leu Arg Thr His Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys 
            500                 505                 510         


Thr Glu Tyr Cys Pro Ser Leu Ser Ser Met Gln Lys His Met Lys Gly 
        515                 520                 525             


His Lys Pro Glu Glu Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr 
    530                 535                 540                 


Leu Tyr Leu Cys Tyr Val 
545                 550 


<210>  36
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Leu Pro 
                245                 250                 255     


Gly Tyr Pro Glu Cys Arg Glu Met Gly Glu Thr Leu Pro Glu Lys Pro 
            260                 265                 270         


Ala Asn Pro Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn 
        275                 280                 285             


Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro 
    290                 295                 300                 


Asp Asp Gln Asn Arg Ile 
305                 310 


<210>  37
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Pro Val Ala Gly Thr Pro Ala Ala Pro Pro 
        35                  40                  45              


Lys Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu 
    50                  55                  60                  


Asp Ser Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro Glu Ser Asp 
65                  70                  75                  80  


Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr His Thr Gln 
                85                  90                  95      


Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly Glu Tyr Thr 
            100                 105                 110         


Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His Leu Thr Val 
        115                 120                 125             


Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu Phe Gln Glu 
    130                 135                 140                 


Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp Lys Pro Leu 
145                 150                 155                 160 


Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys Phe Ser Arg 
                165                 170                 175     


Ser Asp Pro Asn Phe Ser Ile Pro Gln Ala Asn His Ser His Ser Gly 
            180                 185                 190         


Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr Ser Ser Lys 
        195                 200                 205             


Pro Val Thr Ile Thr Val Gln Ala Pro Ser Ser Ser Pro Met Gly Ile 
    210                 215                 220                 


Ile Val Ala Val Val Thr Gly Ile Ala Val Ala Ala Ile Val Ala Ala 
225                 230                 235                 240 


Val Val Ala Leu Ile Tyr Cys Arg Lys Lys Arg Ile Ser Ala Asn Pro 
                245                 250                 255     


Thr Asn Pro Asp Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr 
            260                 265                 270         


Tyr Ser Leu Leu Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln 
        275                 280                 285             


Asn Arg Ile 
    290     


<210>  38
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Ile Leu Ser Phe Leu Pro Val Leu Ala Thr Glu Ser Asp Trp 
1               5                   10                  15      


Ala Asp Cys Lys Ser Pro Gln Pro Trp Gly His Met Leu Leu Trp Thr 
            20                  25                  30          


Ala Val Leu Phe Leu Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu 
        35                  40                  45              


Pro Gln Trp Ile Asn Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys 
    50                  55                  60                  


Arg Gly Thr His Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn 
65                  70                  75                  80  


Gly Asn Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala 
                85                  90                  95      


Asn Asn Asn Asp Ser Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser 
            100                 105                 110         


Leu Ser Asp Pro Val His Leu Thr Val Leu Ser Glu Trp Leu Val Leu 
        115                 120                 125             


Gln Thr Pro His Leu Glu Phe Gln Glu Gly Glu Thr Ile Val Leu Arg 
    130                 135                 140                 


Cys His Ser Trp Lys Asp Lys Pro Leu Val Lys Val Thr Phe Phe Gln 
145                 150                 155                 160 


Asn Gly Lys Ser Lys Lys Phe Ser Arg Ser Asp Pro Asn Phe Ser Ile 
                165                 170                 175     


Pro Gln Ala Asn His Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn 
            180                 185                 190         


Ile Gly Tyr Thr Leu Tyr Ser Ser Lys Pro Val Thr Ile Thr Val Gln 
        195                 200                 205             


Ala Pro Ser Ser Ser Pro Met Gly Ile Ile Val Ala Val Val Thr Gly 
    210                 215                 220                 


Ile Ala Val Ala Ala Ile Val Ala Ala Val Val Ala Leu Ile Tyr Cys 
225                 230                 235                 240 


Arg Lys Lys Arg Ile Ser Ala Leu Pro Gly Tyr Pro Glu Cys Arg Glu 
                245                 250                 255     


Met Gly Glu Thr Leu Pro Glu Lys Pro Ala Asn Pro Thr Asn Pro Asp 
            260                 265                 270         


Glu Ala Asp Lys Val Gly Ala Glu Asn Thr Ile Thr Tyr Ser Leu Leu 
        275                 280                 285             


Met His Pro Asp Ala Leu Glu Glu Pro Asp Asp Gln Asn Arg Ile 
    290                 295                 300             


<210>  39
<211>  543
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Gly Thr Ser Leu Ser Pro Asn Asp Pro Trp Pro Leu Asn Pro Leu 
1               5                   10                  15      


Ser Ile Gln Gln Thr Thr Leu Leu Leu Leu Leu Ser Val Leu Ala Thr 
            20                  25                  30          


Val His Val Gly Gln Arg Leu Leu Arg Gln Arg Arg Arg Gln Leu Arg 
        35                  40                  45              


Ser Ala Pro Pro Gly Pro Phe Ala Trp Pro Leu Ile Gly Asn Ala Ala 
    50                  55                  60                  


Ala Val Gly Gln Ala Ala His Leu Ser Phe Ala Arg Leu Ala Arg Arg 
65                  70                  75                  80  


Tyr Gly Asp Val Phe Gln Ile Arg Leu Gly Ser Cys Pro Ile Val Val 
                85                  90                  95      


Leu Asn Gly Glu Arg Ala Ile His Gln Ala Leu Val Gln Gln Gly Ser 
            100                 105                 110         


Ala Phe Ala Asp Arg Pro Ala Phe Ala Ser Phe Arg Val Val Ser Gly 
        115                 120                 125             


Gly Arg Ser Met Ala Phe Gly His Tyr Ser Glu His Trp Lys Val Gln 
    130                 135                 140                 


Arg Arg Ala Ala His Ser Met Met Arg Asn Phe Phe Thr Arg Gln Pro 
145                 150                 155                 160 


Arg Ser Arg Gln Val Leu Glu Gly His Val Leu Ser Glu Ala Arg Glu 
                165                 170                 175     


Leu Val Ala Leu Leu Val Arg Gly Ser Ala Asp Gly Ala Phe Leu Asp 
            180                 185                 190         


Pro Arg Pro Leu Thr Val Val Ala Val Ala Asn Val Met Ser Ala Val 
        195                 200                 205             


Cys Phe Gly Cys Arg Tyr Ser His Asp Asp Pro Glu Phe Arg Glu Leu 
    210                 215                 220                 


Leu Ser His Asn Glu Glu Phe Gly Arg Thr Val Gly Ala Gly Ser Leu 
225                 230                 235                 240 


Val Asp Val Met Pro Trp Leu Gln Tyr Phe Pro Asn Pro Val Arg Thr 
                245                 250                 255     


Val Phe Arg Glu Phe Glu Gln Leu Asn Arg Asn Phe Ser Asn Phe Ile 
            260                 265                 270         


Leu Asp Lys Phe Leu Arg His Cys Glu Ser Leu Arg Pro Gly Ala Ala 
        275                 280                 285             


Pro Arg Asp Met Met Asp Ala Phe Ile Leu Ser Ala Glu Lys Lys Ala 
    290                 295                 300                 


Ala Gly Asp Ser His Gly Gly Gly Ala Arg Leu Asp Leu Glu Asn Val 
305                 310                 315                 320 


Pro Ala Thr Ile Thr Asp Ile Phe Gly Ala Ser Gln Asp Thr Leu Ser 
                325                 330                 335     


Thr Ala Leu Gln Trp Leu Leu Leu Leu Phe Thr Arg Tyr Pro Asp Val 
            340                 345                 350         


Gln Thr Arg Val Gln Ala Glu Leu Asp Gln Val Val Gly Arg Asp Arg 
        355                 360                 365             


Leu Pro Cys Met Gly Asp Gln Pro Asn Leu Pro Tyr Val Leu Ala Phe 
    370                 375                 380                 


Leu Tyr Glu Ala Met Arg Phe Ser Ser Phe Val Pro Val Thr Ile Pro 
385                 390                 395                 400 


His Ala Thr Thr Ala Asn Thr Ser Val Leu Gly Tyr His Ile Pro Lys 
                405                 410                 415     


Asp Thr Val Val Phe Val Asn Gln Trp Ser Val Asn His Asp Pro Leu 
            420                 425                 430         


Lys Trp Pro Asn Pro Glu Asn Phe Asp Pro Ala Arg Phe Leu Asp Lys 
        435                 440                 445             


Asp Gly Leu Ile Asn Lys Asp Leu Thr Ser Arg Val Met Ile Phe Ser 
    450                 455                 460                 


Val Gly Lys Arg Arg Cys Ile Gly Glu Glu Leu Ser Lys Met Gln Leu 
465                 470                 475                 480 


Phe Leu Phe Ile Ser Ile Leu Ala His Gln Cys Asp Phe Arg Ala Asn 
                485                 490                 495     


Pro Asn Glu Pro Ala Lys Met Asn Phe Ser Tyr Gly Leu Thr Ile Lys 
            500                 505                 510         


Pro Lys Ser Phe Lys Val Asn Val Thr Leu Arg Glu Ser Met Glu Leu 
        515                 520                 525             


Leu Asp Ser Ala Val Gln Asn Leu Gln Ala Lys Glu Thr Cys Gln 
    530                 535                 540             


<210>  40
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Pro Val Leu Ser Lys Asp Ser Ala Asp Ile Glu Ser Ile Leu 
1               5                   10                  15      


Ala Leu Asn Pro Arg Thr Gln Thr His Ala Thr Leu Cys Ser Thr Ser 
            20                  25                  30          


Ala Lys Lys Leu Asp Lys Lys His Trp Lys Arg Asn Pro Asp Lys Asn 
        35                  40                  45              


Cys Phe Asn Cys Glu Lys Leu Glu Asn Asn Phe Asp Asp Ile Lys His 
    50                  55                  60                  


Thr Thr Leu Gly Glu Arg Gly Ala Leu Arg Glu Ala Met Arg Cys Leu 
65                  70                  75                  80  


Lys Cys Ala Asp Ala Pro Cys Gln Lys Ser Cys Pro Thr Asn Leu Asp 
                85                  90                  95      


Ile Lys Ser Phe Ile Thr Ser Ile Ala Asn Lys Asn Tyr Tyr Gly Ala 
            100                 105                 110         


Ala Lys Met Ile Phe Ser Asp Asn Pro Leu Gly Leu Thr Cys Gly Met 
        115                 120                 125             


Val Cys Pro Thr Ser Asp Leu Cys Val Gly Gly Cys Asn Leu Tyr Ala 
    130                 135                 140                 


Thr Glu Glu Gly Pro Ile Asn Ile Gly Gly Leu Gln Gln Phe Ala Thr 
145                 150                 155                 160 


Glu Val Phe Lys Ala Met Ser Ile Pro Gln Ile Arg Asn Pro Ser Leu 
                165                 170                 175     


Pro Pro Pro Glu Lys Met Ser Glu Ala Tyr Ser Ala Lys Ile Ala Leu 
            180                 185                 190         


Phe Gly Ala Gly Pro Ala Ser Ile Ser Cys Ala Ser Phe Leu Ala Arg 
        195                 200                 205             


Leu Gly Tyr Ser Asp Ile Thr Ile Phe Glu Lys Gln Glu Tyr Val Gly 
    210                 215                 220                 


Gly Leu Ser Thr Ser Glu Ile Pro Gln Phe Arg Leu Pro Tyr Asp Val 
225                 230                 235                 240 


Val Asn Phe Glu Ile Glu Leu Met Lys Asp Leu Gly Val Lys Ile Ile 
                245                 250                 255     


Cys Gly Lys Ser Leu Ser Val Asn Glu Met Thr Leu Ser Thr Leu Lys 
            260                 265                 270         


Glu Lys Gly Tyr Lys Ala Ala Phe Ile Gly Ile Gly Leu Pro Glu Pro 
        275                 280                 285             


Asn Lys Asp Ala Ile Phe Gln Gly Leu Thr Gln Asp Gln Gly Phe Tyr 
    290                 295                 300                 


Thr Ser Lys Asp Phe Leu Pro Leu Val Ala Lys Gly Ser Lys Ala Gly 
305                 310                 315                 320 


Met Cys Ala Cys His Ser Pro Leu Pro Ser Ile Arg Gly Val Val Ile 
                325                 330                 335     


Val Leu Gly Ala Gly Asp Thr Ala Phe Asp Cys Ala Thr Ser Ala Leu 
            340                 345                 350         


Arg Cys Gly Ala Arg Arg Val Phe Ile Val Phe Arg Lys Gly Phe Val 
        355                 360                 365             


Asn Ile Arg Ala Val Pro Glu Glu Met Glu Leu Ala Lys Glu Glu Lys 
    370                 375                 380                 


Cys Glu Phe Leu Pro Phe Leu Ser Pro Arg Lys Val Ile Val Lys Gly 
385                 390                 395                 400 


Gly Arg Ile Val Ala Met Gln Phe Val Arg Thr Glu Gln Asp Glu Thr 
                405                 410                 415     


Gly Lys Trp Asn Glu Asp Glu Asp Gln Met Val His Leu Lys Ala Asp 
            420                 425                 430         


Val Val Ile Ser Ala Phe Gly Ser Val Leu Ser Asp Pro Lys Val Lys 
        435                 440                 445             


Glu Ala Leu Ser Pro Ile Lys Phe Asn Arg Trp Gly Leu Pro Glu Val 
    450                 455                 460                 


Asp Pro Glu Thr Met Gln Thr Ser Glu Ala Trp Val Phe Ala Gly Gly 
465                 470                 475                 480 


Asp Val Val Gly Leu Ala Asn Thr Thr Val Glu Ser Val Asn Asp Gly 
                485                 490                 495     


Lys Gln Ala Ser Trp Tyr Ile His Lys Tyr Val Gln Ser Gln Tyr Gly 
            500                 505                 510         


Ala Ser Val Ser Ala Lys Pro Glu Leu Pro Leu Phe Tyr Thr Pro Ile 
        515                 520                 525             


Asp Leu Val Asp Ile Ser Val Glu Met Ala Gly Leu Lys Phe Ile Asn 
    530                 535                 540                 


Pro Phe Gly Leu Ala Ser Ala Thr Pro Ala Thr Ser Thr Ser Met Ile 
545                 550                 555                 560 


Arg Arg Ala Phe Glu Ala Gly Trp Gly Phe Ala Leu Thr Lys Thr Phe 
                565                 570                 575     


Ser Leu Asp Lys Asp Ile Val Thr Asn Val Ser Pro Arg Ile Ile Arg 
            580                 585                 590         


Gly Thr Thr Ser Gly Pro Met Tyr Gly Pro Gly Gln Ser Ser Phe Leu 
        595                 600                 605             


Asn Ile Glu Leu Ile Ser Glu Lys Thr Ala Ala Tyr Trp Cys Gln Ser 
    610                 615                 620                 


Val Thr Glu Leu Lys Ala Asp Phe Pro Asp Asn Ile Val Ile Ala Ser 
625                 630                 635                 640 


Ile Met Cys Ser Tyr Asn Lys Asn Asp Trp Thr Glu Leu Ala Lys Lys 
                645                 650                 655     


Ser Glu Asp Ser Gly Ala Asp Ala Leu Glu Leu Asn Leu Ser Cys Pro 
            660                 665                 670         


His Gly Met Gly Glu Arg Gly Met Gly Leu Ala Cys Gly Gln Asp Pro 
        675                 680                 685             


Glu Leu Val Arg Asn Ile Cys Arg Trp Val Arg Gln Ala Val Gln Ile 
    690                 695                 700                 


Pro Phe Phe Ala Lys Leu Thr Pro Asn Val Thr Asp Ile Val Ser Ile 
705                 710                 715                 720 


Ala Arg Ala Ala Lys Glu Gly Gly Ala Asn Gly Val Thr Ala Thr Asn 
                725                 730                 735     


Thr Val Ser Gly Leu Met Gly Leu Lys Ser Asp Gly Thr Pro Trp Pro 
            740                 745                 750         


Ala Val Gly Ile Ala Lys Arg Thr Thr Tyr Gly Gly Val Ser Gly Thr 
        755                 760                 765             


Ala Ile Arg Pro Ile Ala Leu Arg Ala Val Thr Ser Ile Ala Arg Ala 
    770                 775                 780                 


Leu Pro Gly Phe Pro Ile Leu Ala Thr Gly Gly Ile Asp Ser Ala Glu 
785                 790                 795                 800 


Ser Gly Leu Gln Phe Leu His Ser Gly Ala Ser Val Leu Gln Val Cys 
                805                 810                 815     


Ser Ala Ile Gln Asn Gln Asp Phe Thr Val Ile Glu Asp Tyr Cys Thr 
            820                 825                 830         


Gly Leu Lys Ala Leu Leu Tyr Leu Lys Ser Ile Glu Glu Leu Gln Asp 
        835                 840                 845             


Trp Asp Gly Gln Ser Pro Ala Thr Val Ser His Gln Lys Gly Lys Pro 
    850                 855                 860                 


Val Pro Arg Ile Ala Glu Leu Met Asp Lys Lys Leu Pro Ser Phe Gly 
865                 870                 875                 880 


Pro Tyr Leu Glu Gln Arg Lys Lys Ile Ile Ala Glu Asn Lys Ile Arg 
                885                 890                 895     


Leu Lys Glu Gln Asn Val Ala Phe Ser Pro Leu Lys Arg Asn Cys Phe 
            900                 905                 910         


Ile Pro Lys Arg Pro Ile Pro Thr Ile Lys Asp Val Ile Gly Lys Ala 
        915                 920                 925             


Leu Gln Tyr Leu Gly Thr Phe Gly Glu Leu Ser Asn Val Glu Gln Val 
    930                 935                 940                 


Val Ala Met Ile Asp Glu Glu Met Cys Ile Asn Cys Gly Lys Cys Tyr 
945                 950                 955                 960 


Met Thr Cys Asn Asp Ser Gly Tyr Gln Ala Ile Gln Phe Asp Pro Glu 
                965                 970                 975     


Thr His Leu Pro Thr Ile Thr Asp Thr Cys Thr Gly Cys Thr Leu Cys 
            980                 985                 990         


Leu Ser Val Cys Pro Ile Val Asp  Cys Ile Lys Met Val  Ser Arg Thr 
        995                 1000                 1005             


Thr Pro  Tyr Glu Pro Lys Arg  Gly Val Pro Leu Ser  Val Asn Pro 
    1010                 1015                 1020             


Val Cys  
    1025 


<210>  41
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Pro Val Leu Ser Lys Asp Ser Ala Asp Ile Glu Ser Ile Leu 
1               5                   10                  15      


Ala Leu Asn Pro Arg Thr Gln Thr His Ala Thr Leu Cys Ser Thr Ser 
            20                  25                  30          


Ala Lys Lys Leu Asp Lys Lys His Trp Lys Arg Asn Pro Asp Lys Asn 
        35                  40                  45              


Cys Phe Asn Cys Glu Lys Leu Glu Asn Asn Phe Asp Asp Ile Lys His 
    50                  55                  60                  


Thr Thr Leu Gly Glu Arg Gly Ala Leu Arg Glu Ala Met Arg Cys Leu 
65                  70                  75                  80  


Lys Cys Ala Asp Ala Pro Cys Gln Lys Ser Cys Pro Thr Asn Leu Asp 
                85                  90                  95      


Ile Lys Ser Phe Ile Thr Ser Ile Ala Asn Lys Asn Tyr Tyr Gly Ala 
            100                 105                 110         


Ala Lys Met Ile Phe Ser Asp Asn Pro Leu Gly Leu Thr Cys Gly Met 
        115                 120                 125             


Val Cys Pro Thr Ser Asp Leu Cys Val Gly Gly Cys Asn Leu Tyr Ala 
    130                 135                 140                 


Thr Glu Glu Gly Pro Ile Asn Ile Gly Gly Leu Gln Gln Phe Ala Thr 
145                 150                 155                 160 


Glu Thr Leu Ile Leu Ala Phe Ser Leu Met Asn His Leu 
                165                 170             


<210>  42
<211>  637
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Gly Leu Leu Ser Gln Gly Ser Pro Leu Ser Trp Glu Glu Thr Lys 
1               5                   10                  15      


Arg His Ala Asp His Val Arg Arg His Gly Ile Leu Gln Phe Leu His 
            20                  25                  30          


Ile Tyr His Ala Val Lys Asp Arg His Lys Asp Val Leu Lys Trp Gly 
        35                  40                  45              


Asp Glu Val Glu Tyr Met Leu Val Ser Phe Asp His Glu Asn Lys Lys 
    50                  55                  60                  


Val Arg Leu Val Leu Ser Gly Glu Lys Val Leu Glu Thr Leu Gln Glu 
65                  70                  75                  80  


Lys Gly Glu Arg Thr Asn Pro Asn His Pro Thr Leu Trp Arg Pro Glu 
                85                  90                  95      


Tyr Gly Ser Tyr Met Ile Glu Gly Thr Pro Gly Gln Pro Tyr Gly Gly 
            100                 105                 110         


Thr Met Ser Glu Phe Asn Thr Val Glu Ala Asn Met Arg Lys Arg Arg 
        115                 120                 125             


Lys Glu Ala Thr Ser Ile Leu Glu Glu Asn Gln Ala Leu Cys Thr Ile 
    130                 135                 140                 


Thr Ser Phe Pro Arg Leu Gly Cys Pro Gly Phe Thr Leu Pro Glu Val 
145                 150                 155                 160 


Lys Pro Asn Pro Val Glu Gly Gly Ala Ser Lys Ser Leu Phe Phe Pro 
                165                 170                 175     


Asp Glu Ala Ile Asn Lys His Pro Arg Phe Ser Thr Leu Thr Arg Asn 
            180                 185                 190         


Ile Arg His Arg Arg Gly Glu Lys Val Val Ile Asn Val Pro Ile Phe 
        195                 200                 205             


Lys Asp Lys Asn Thr Pro Ser Pro Phe Ile Glu Thr Phe Thr Glu Asp 
    210                 215                 220                 


Asp Glu Ala Ser Arg Ala Ser Lys Pro Asp His Ile Tyr Met Asp Ala 
225                 230                 235                 240 


Met Gly Phe Gly Met Gly Asn Cys Cys Leu Gln Val Thr Phe Gln Ala 
                245                 250                 255     


Cys Ser Ile Ser Glu Ala Arg Tyr Leu Tyr Asp Gln Leu Ala Thr Ile 
            260                 265                 270         


Cys Pro Ile Val Met Ala Leu Ser Ala Ala Ser Pro Phe Tyr Arg Gly 
        275                 280                 285             


Tyr Val Ser Asp Ile Asp Cys Arg Trp Gly Val Ile Ser Ala Ser Val 
    290                 295                 300                 


Asp Asp Arg Thr Arg Glu Glu Arg Gly Leu Glu Pro Leu Lys Asn Asn 
305                 310                 315                 320 


Asn Tyr Arg Ile Ser Lys Ser Arg Tyr Asp Ser Ile Asp Ser Tyr Leu 
                325                 330                 335     


Ser Lys Cys Gly Glu Lys Tyr Asn Asp Ile Asp Leu Thr Ile Asp Lys 
            340                 345                 350         


Glu Ile Tyr Glu Gln Leu Leu Gln Glu Gly Ile Asp His Leu Leu Ala 
        355                 360                 365             


Gln His Val Ala His Leu Phe Ile Arg Asp Pro Leu Thr Leu Phe Glu 
    370                 375                 380                 


Glu Lys Ile His Leu Asp Asp Ala Asn Glu Ser Asp His Phe Glu Asn 
385                 390                 395                 400 


Ile Gln Ser Thr Asn Trp Gln Thr Met Arg Phe Lys Pro Pro Pro Pro 
                405                 410                 415     


Asn Ser Asp Ile Gly Trp Arg Val Glu Phe Arg Pro Met Glu Val Gln 
            420                 425                 430         


Leu Thr Asp Phe Glu Asn Ser Ala Tyr Val Val Phe Val Val Leu Leu 
        435                 440                 445             


Thr Arg Val Ile Leu Ser Tyr Lys Leu Asp Phe Leu Ile Pro Leu Ser 
    450                 455                 460                 


Lys Val Asp Glu Asn Met Lys Val Ala Gln Lys Arg Asp Ala Val Leu 
465                 470                 475                 480 


Gln Gly Met Phe Tyr Phe Arg Lys Asp Ile Cys Lys Gly Gly Asn Ala 
                485                 490                 495     


Val Val Asp Gly Cys Gly Lys Ala Gln Asn Ser Thr Glu Leu Ala Ala 
            500                 505                 510         


Glu Glu Tyr Thr Leu Met Ser Ile Asp Thr Ile Ile Asn Gly Lys Glu 
        515                 520                 525             


Gly Val Phe Pro Gly Leu Ile Pro Ile Leu Asn Ser Tyr Leu Glu Asn 
    530                 535                 540                 


Met Glu Val Asp Val Asp Thr Arg Cys Ser Ile Leu Asn Tyr Leu Lys 
545                 550                 555                 560 


Leu Ile Lys Lys Arg Ala Ser Gly Glu Leu Met Thr Val Ala Arg Trp 
                565                 570                 575     


Met Arg Glu Phe Ile Ala Asn His Pro Asp Tyr Lys Gln Asp Ser Val 
            580                 585                 590         


Ile Thr Asp Glu Met Asn Tyr Ser Leu Ile Leu Lys Cys Asn Gln Ile 
        595                 600                 605             


Ala Asn Glu Leu Cys Glu Cys Pro Glu Leu Leu Gly Ser Ala Phe Arg 
    610                 615                 620                 


Lys Val Lys Tyr Ser Gly Ser Lys Thr Asp Ser Ser Asn 
625                 630                 635         


<210>  43
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ile Pro Asn Gly Tyr Leu Met Phe Glu Asp Glu Asn Phe Ile Glu 
1               5                   10                  15      


Ser Ser Val Ala Lys Leu Asn Ala Leu Arg Lys Ser Gly Gln Phe Cys 
            20                  25                  30          


Asp Val Arg Leu Gln Val Cys Gly His Glu Met Leu Ala His Arg Ala 
        35                  40                  45              


Val Leu Ala Cys Cys Ser Pro Tyr Leu Phe Glu Ile Phe Asn Ser Asp 
    50                  55                  60                  


Ser Asp Pro His Gly Ile Ser His Val Lys Phe Asp Asp Leu Asn Pro 
65                  70                  75                  80  


Glu Ala Val Glu Val Leu Leu Asn Tyr Ala Tyr Thr Ala Gln Leu Lys 
                85                  90                  95      


Ala Asp Lys Glu Leu Val Lys Asp Val Tyr Ser Ala Ala Lys Lys Leu 
            100                 105                 110         


Lys Met Asp Arg Val Lys Gln Val Cys Gly Asp Tyr Leu Leu Ser Arg 
        115                 120                 125             


Met Asp Val Thr Ser Cys Ile Ser Tyr Arg Asn Phe Ala Ser Cys Met 
    130                 135                 140                 


Gly Asp Ser Arg Leu Leu Asn Lys Val Asp Ala Tyr Ile Gln Glu His 
145                 150                 155                 160 


Leu Leu Gln Ile Ser Glu Glu Glu Glu Phe Leu Lys Leu Pro Arg Leu 
                165                 170                 175     


Lys Leu Glu Val Met Leu Glu Asp Asn Val Cys Leu Pro Ser Asn Gly 
            180                 185                 190         


Lys Leu Tyr Thr Lys Val Ile Asn Trp Val Gln Arg Ser Ile Trp Glu 
        195                 200                 205             


Asn Gly Asp Ser Leu Glu Glu Leu Met Glu Glu Val Gln Thr Leu Tyr 
    210                 215                 220                 


Tyr Ser Ala Asp His Lys Leu Leu Asp Gly Asn Leu Leu Asp Gly Gln 
225                 230                 235                 240 


Ala Glu Val Phe Gly Ser Asp Asp Asp His Ile Gln Phe Val Gln Lys 
                245                 250                 255     


Lys Pro Pro Arg Glu Asn Gly His Lys Gln Ile Ser Ser Ser Ser Thr 
            260                 265                 270         


Gly Cys Leu Ser Ser Pro Asn Ala Thr Val Gln Ser Pro Lys His Glu 
        275                 280                 285             


Trp Lys Ile Val Ala Ser Glu Lys Thr Ser Asn Asn Thr Tyr Leu Cys 
    290                 295                 300                 


Leu Ala Val Leu Asp Gly Ile Phe Cys Val Ile Phe Leu His Gly Arg 
305                 310                 315                 320 


Asn Ser Pro Gln Ser Ser Pro Thr Ser Thr Pro Lys Leu Ser Lys Ser 
                325                 330                 335     


Leu Ser Phe Glu Met Gln Gln Asp Glu Leu Ile Glu Lys Pro Met Ser 
            340                 345                 350         


Pro Met Gln Tyr Ala Arg Ser Gly Leu Gly Thr Ala Glu Met Asn Gly 
        355                 360                 365             


Lys Leu Ile Ala Ala Gly Gly Tyr Asn Arg Glu Glu Cys Leu Arg Thr 
    370                 375                 380                 


Val Glu Cys Tyr Asn Pro His Thr Asp His Trp Ser Phe Leu Ala Pro 
385                 390                 395                 400 


Met Arg Thr Pro Arg Ala Arg Phe Gln Met Ala Val Leu Met Gly Gln 
                405                 410                 415     


Leu Tyr Val Val Gly Gly Ser Asn Gly His Ser Asp Asp Leu Ser Cys 
            420                 425                 430         


Gly Glu Met Tyr Asp Ser Asn Ile Asp Asp Trp Ile Pro Val Pro Glu 
        435                 440                 445             


Leu Arg Thr Asn Arg Cys Asn Ala Gly Val Cys Ala Leu Asn Gly Lys 
    450                 455                 460                 


Leu Tyr Ile Val Gly Gly Ser Asp Pro Tyr Gly Gln Lys Gly Leu Lys 
465                 470                 475                 480 


Asn Cys Asp Val Phe Asp Pro Val Thr Lys Leu Trp Thr Ser Cys Ala 
                485                 490                 495     


Pro Leu Asn Ile Arg Arg His Gln Ser Ala Val Cys Glu Leu Gly Gly 
            500                 505                 510         


Tyr Leu Tyr Ile Ile Gly Gly Ala Glu Ser Trp Asn Cys Leu Asn Thr 
        515                 520                 525             


Val Glu Arg Tyr Asn Pro Glu Asn Asn Thr Trp Thr Leu Ile Ala Pro 
    530                 535                 540                 


Met Asn Val Ala Arg Arg Gly Ala Gly Val Ala Val Leu Asn Gly Lys 
545                 550                 555                 560 


Leu Phe Val Cys Gly Gly Phe Asp Gly Ser His Ala Ile Ser Cys Val 
                565                 570                 575     


Glu Met Tyr Asp Pro Thr Arg Asn Glu Trp Lys Met Met Gly Asn Met 
            580                 585                 590         


Thr Ser Pro Arg Ser Asn Ala Gly Ile Ala Thr Val Gly Asn Thr Ile 
        595                 600                 605             


Tyr Ala Val Gly Gly Phe Asp Gly Asn Glu Phe Leu Asn Thr Val Glu 
    610                 615                 620                 


Val Tyr Asn Leu Glu Ser Asn Glu Trp Ser Pro Tyr Thr Lys Ile Phe 
625                 630                 635                 640 


Gln Phe 
        


<210>  44
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Gly Gly Thr Leu Ala Trp Thr Leu Leu Leu Pro Leu Leu Leu Arg 
1               5                   10                  15      


Glu Ser Asp Ser Leu Glu Pro Ser Cys Thr Val Ser Ser Ala Asp Val 
            20                  25                  30          


Asp Trp Asn Ala Glu Phe Ser Ala Thr Cys Leu Asn Phe Ser Gly Leu 
        35                  40                  45              


Ser Leu Ser Leu Pro His Asn Gln Ser Leu Arg Ala Ser Asn Val Ile 
    50                  55                  60                  


Leu Leu Asp Leu Ser Gly Asn Gly Leu Arg Glu Leu Pro Val Thr Phe 
65                  70                  75                  80  


Phe Ala His Leu Gln Lys Leu Glu Val Leu Asn Val Leu Arg Asn Pro 
                85                  90                  95      


Leu Ser Arg Val Asp Gly Ala Leu Ala Ala Arg Cys Asp Leu Asp Leu 
            100                 105                 110         


Gln Ala Asp Cys Asn Cys Ala Leu Glu Ser Trp His Asp Ile Arg Arg 
        115                 120                 125             


Asp Asn Cys Ser Gly Gln Lys Pro Leu Leu Cys Trp Asp Thr Thr Ser 
    130                 135                 140                 


Ser Gln His Asn Leu Ser Ala Phe Leu Glu Val Ser Cys Ala Pro Gly 
145                 150                 155                 160 


Leu Ala Ser Ala Thr Ile Gly Ala Val Val Val Ser Gly Cys Leu Leu 
                165                 170                 175     


Leu Gly Leu Ala Ile Ala Gly Pro Val Leu Ala Trp Arg Leu Trp Arg 
            180                 185                 190         


Cys Arg Val Ala Arg Ser Arg Glu Leu Asn Lys Pro Trp Ala Ala Gln 
        195                 200                 205             


Asp Gly Pro Lys Pro Gly Leu Gly Leu Gln Pro Arg Tyr Gly Ser Arg 
    210                 215                 220                 


Ser Ala Pro Lys Pro Gln Val Ala Val Pro Ser Cys Pro Ser Thr Pro 
225                 230                 235                 240 


Asp Tyr Glu Asn Met Phe Val Gly Gln Pro Ala Ala Glu His Gln Trp 
                245                 250                 255     


Asp Glu Gln Gly Ala His Pro Ser Glu Asp Asn Asp Phe Tyr Ile Asn 
            260                 265                 270         


Tyr Lys Asp Ile Asp Leu Ala Ser Gln Pro Val Tyr Cys Asn Leu Gln 
        275                 280                 285             


Ser Leu Gly Gln Ala Pro Met Asp Glu Glu Glu Tyr Val Ile Pro Gly 
    290                 295                 300                 


His 
305 


<210>  45
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Ala Gly Ala Arg Arg Leu Glu Leu Gly Glu Ala Leu Ala Leu Gly 
1               5                   10                  15      


Ser Gly Trp Arg His Ala Cys His Ala Leu Leu Tyr Ala Pro Asp Pro 
            20                  25                  30          


Gly Met Leu Phe Gly Arg Ile Pro Leu Arg Tyr Ala Ile Leu Met Gln 
        35                  40                  45              


Met Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val Asp Thr 
    50                  55                  60                  


Gln Asp Arg Ser Leu Glu Asp Gly Leu Asn Arg Glu Leu Arg Glu Glu 
65                  70                  75                  80  


Leu Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Thr Asp Tyr Arg 
                85                  90                  95      


Ser Ser His Val Gly Ser Gly Pro Arg Val Val Ala His Phe Tyr Ala 
            100                 105                 110         


Lys Arg Leu Thr Leu Glu Glu Leu Leu Ala Val Glu Ala Gly Ala Thr 
        115                 120                 125             


Arg Ala Lys Asp His Gly Leu Glu Val Leu Gly Leu Val Arg Val Pro 
    130                 135                 140                 


Leu Tyr Thr Leu Arg Asp Gly Val Gly Gly Leu Pro Thr Phe Leu Glu 
145                 150                 155                 160 


Asn Ser Phe Ile Gly Ser Ala Arg Glu Gln Leu Leu Glu Ala Leu Gln 
                165                 170                 175     


Asp Leu Gly Leu Leu Gln Ser Gly Ser Ile Ser Gly Leu Lys Ile Pro 
            180                 185                 190         


Ala His His 
        195 


<210>  46
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Leu Phe Gly Arg Ile Pro Leu Arg Tyr Ala Ile Leu Met Gln Met 
1               5                   10                  15      


Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val Asp Thr Gln 
            20                  25                  30          


Asp Arg Ser Leu Glu Asp Gly Leu Asn Arg Glu Leu Arg Glu Glu Leu 
        35                  40                  45              


Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Thr Asp Tyr Arg Ser 
    50                  55                  60                  


Ser His Val Gly Ser Gly Pro Arg Val Val Ala His Phe Tyr Ala Lys 
65                  70                  75                  80  


Arg Leu Thr Leu Glu Glu Leu Leu Ala Val Glu Ala Gly Ala Thr Arg 
                85                  90                  95      


Ala Lys Asp His Gly Leu Glu Val Gly Pro Ala Trp Asp Ser Val Pro 
            100                 105                 110         


Phe Pro Ile Ser Ser Ser Pro Lys Ala Phe Ser Pro Pro Arg Lys His 
        115                 120                 125             


Pro Trp Arg Lys Val Phe Ala Pro Leu Thr Leu Pro Ser Pro Gln Leu 
    130                 135                 140                 


Ser Trp Trp Ser Trp Asp Arg Asp His Leu Tyr Ser Glu Leu Val Leu 
145                 150                 155                 160 


Pro Thr Trp Ala Phe Cys Lys Gly Leu Ser His Pro Leu Pro Gly Glu 
                165                 170                 175     


Ile Leu Ser Arg Thr His Ser Ser Met Ser Leu Cys Cys Ser Leu Leu 
            180                 185                 190         


Thr Val 
        


<210>  47
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Gln Met Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val 
1               5                   10                  15      


Asp Thr Gln Asp Arg Ser Leu Glu Asp Gly Leu Asn Arg Glu Leu Arg 
            20                  25                  30          


Glu Glu Leu Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Thr Asp 
        35                  40                  45              


Tyr Arg Ser Ser His Val Gly Ser Gly Pro Arg Val Val Ala His Phe 
    50                  55                  60                  


Tyr Ala Lys Arg Leu Thr Leu Glu Glu Leu Leu Ala Val Glu Ala Gly 
65                  70                  75                  80  


Ala Thr Arg Ala Lys Asp His Gly Leu Glu Val Leu Gly Leu Val Arg 
                85                  90                  95      


Val Pro Leu Tyr Thr Leu Arg Asp Gly Val Gly Gly Leu Pro Thr Phe 
            100                 105                 110         


Leu Glu Asn Ser Phe Ile Gly Ser Ala Arg Glu Gln Leu Leu Glu Ala 
        115                 120                 125             


Ala Leu His Gly Pro Met Lys Thr Glu Met Arg Thr Leu Val Leu Gly 
    130                 135                 140                 


Arg Glu Gly Arg Thr Trp Glu Cys Phe Leu Ile Gly Ser Glu Arg 
145                 150                 155                 


<210>  48
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Gly Ala Arg Arg Leu Glu Leu Gly Glu Ala Leu Ala Leu Gly 
1               5                   10                  15      


Ser Gly Trp Arg His Ala Cys His Ala Leu Leu Tyr Ala Pro Asp Pro 
            20                  25                  30          


Gly Met Leu Phe Gly Arg Ile Pro Leu Arg Tyr Ala Ile Leu Met Gln 
        35                  40                  45              


Met Arg Phe Asp Gly Arg Leu Gly Phe Pro Gly Gly Phe Val Asp Thr 
    50                  55                  60                  


Gln Asp Arg Ser Leu Glu Asp Gly Leu Asn Arg Glu Leu Arg Glu Glu 
65                  70                  75                  80  


Leu Gly Glu Ala Ala Ala Ala Phe Arg Val Glu Arg Thr Asp Tyr Arg 
                85                  90                  95      


Ser Ser His Val Gly Ser Gly Pro Arg Val Val Ala His Phe Tyr Ala 
            100                 105                 110         


Lys Arg Leu Thr Leu Glu Glu Leu Leu Ala Val Glu Ala Gly Ala Thr 
        115                 120                 125             


Arg Ala Lys Asp His Gly Leu Glu Val Gly Pro Ala Trp Asp Ser Val 
    130                 135                 140                 


Pro Phe Pro Ile Ser Ser Ser Pro Lys Ala Phe Ser Pro Pro Arg Lys 
145                 150                 155                 160 


His Pro Trp Arg Lys Val Phe Ala Pro Leu Thr Leu Pro Ser Pro Gln 
                165                 170                 175     


Leu Ser Trp Trp Ser Trp Asp Arg Asp His Leu Tyr Ser Glu Leu Val 
            180                 185                 190         


Leu Pro Thr Trp Ala Phe Cys Lys Gly Leu Ser His Pro Leu Pro Gly 
        195                 200                 205             


Glu Ile Leu Ser Arg Thr His Ser Ser Met Ser Leu Cys Cys Ser Leu 
    210                 215                 220                 


Leu Thr Val 
225         


<210>  49
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Asp Val Glu Asn Glu Gln Ile Leu Asn Val Asn Pro Ala Asp Pro 
1               5                   10                  15      


Asp Asn Leu Ser Asp Ser Leu Phe Ser Gly Asp Glu Glu Asn Ala Gly 
            20                  25                  30          


Thr Glu Glu Ile Lys Asn Glu Ile Asn Gly Asn Trp Ile Ser Ala Ser 
        35                  40                  45              


Ser Ile Asn Glu Ala Arg Ile Asn Ala Lys Ala Lys Arg Arg Leu Arg 
    50                  55                  60                  


Lys Asn Ser Ser Arg Asp Ser Gly Arg Gly Asp Ser Val Ser Asp Ser 
65                  70                  75                  80  


Gly Ser Asp Ala Leu Arg Ser Gly Leu Thr Val Pro Thr Ser Pro Lys 
                85                  90                  95      


Gly Arg Leu Leu Asp Arg Arg Ser Arg Ser Gly Lys Gly Arg Gly Leu 
            100                 105                 110         


Pro Lys Lys Gly Gly Ala Gly Gly Lys Gly Val Trp Gly Thr Pro Gly 
        115                 120                 125             


Gln Val Tyr Asp Val Glu Glu Val Asp Val Lys Asp Pro Asn Tyr Asp 
    130                 135                 140                 


Asp Asp Gln Glu Asn Cys Val Tyr Glu Thr Val Val Leu Pro Leu Asp 
145                 150                 155                 160 


Glu Arg Ala Phe Glu Lys Thr Leu Thr Pro Ile Ile Gln Glu Tyr Phe 
                165                 170                 175     


Glu His Gly Asp Thr Asn Glu Val Ala Glu Met Leu Arg Asp Leu Asn 
            180                 185                 190         


Leu Gly Glu Met Lys Ser Gly Val Pro Val Leu Ala Val Ser Leu Ala 
        195                 200                 205             


Leu Glu Gly Lys Ala Ser His Arg Glu Met Thr Ser Lys Leu Leu Ser 
    210                 215                 220                 


Asp Leu Cys Gly Thr Val Met Ser Thr Thr Asp Val Glu Lys Ser Phe 
225                 230                 235                 240 


Asp Lys Leu Leu Lys Asp Leu Pro Glu Leu Ala Leu Asp Thr Pro Arg 
                245                 250                 255     


Ala Pro Gln Leu Val Gly Gln Phe Ile Ala Arg Ala Val Gly Asp Gly 
            260                 265                 270         


Ile Leu Cys Asn Thr Tyr Ile Asp Ser Tyr Lys Gly Thr Val Asp Cys 
        275                 280                 285             


Val Gln Ala Arg Ala Ala Leu Asp Lys Ala Thr Val Leu Leu Ser Met 
    290                 295                 300                 


Ser Lys Gly Gly Lys Arg Lys Asp Ser Val Trp Gly Ser Gly Gly Gly 
305                 310                 315                 320 


Gln Gln Ser Val Asn His Leu Val Lys Glu Ile Asp Met Leu Leu Lys 
                325                 330                 335     


Glu Tyr Leu Leu Ser Gly Asp Ile Ser Glu Ala Glu His Cys Leu Lys 
            340                 345                 350         


Glu Leu Glu Val Pro His Phe His His Glu Leu Val Tyr Glu Ala Ile 
        355                 360                 365             


Ile Met Val Leu Glu Ser Thr Gly Glu Ser Thr Phe Lys Met Ile Leu 
    370                 375                 380                 


Asp Leu Leu Lys Ser Leu Trp Lys Ser Ser Thr Ile Thr Val Asp Gln 
385                 390                 395                 400 


Met Lys Arg Gly Tyr Glu Arg Ile Tyr Asn Glu Ile Pro Asp Ile Asn 
                405                 410                 415     


Leu Asp Val Pro His Ser Tyr Ser Val Leu Glu Arg Phe Val Glu Glu 
            420                 425                 430         


Cys Phe Gln Ala Gly Ile Ile Ser Lys Gln Leu Arg Asp Leu Cys Pro 
        435                 440                 445             


Ser Arg Gly Arg Lys Arg Phe Val Ser Glu Gly Asp Gly Gly Arg Leu 
    450                 455                 460                 


Lys Pro Glu Ser Tyr 
465                 


<210>  50
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Lys Tyr Pro Asp Asn Leu Ser Asp Ser Leu Phe Ser Gly Asp 
1               5                   10                  15      


Glu Glu Asn Ala Gly Thr Glu Glu Ile Lys Asn Glu Ile Asn Gly Asn 
            20                  25                  30          


Trp Ile Ser Ala Ser Ser Ile Asn Glu Ala Arg Ile Asn Ala Lys Ala 
        35                  40                  45              


Lys Arg Arg Leu Arg Lys Asn Ser Ser Arg Asp Ser Gly Arg Gly Asp 
    50                  55                  60                  


Ser Val Ser Asp Ser Gly Ser Asp Ala Leu Arg Ser Gly Leu Thr Val 
65                  70                  75                  80  


Pro Thr Ser Pro Lys Gly Arg Leu Leu Asp Arg Arg Ser Arg Ser Gly 
                85                  90                  95      


Lys Gly Arg Gly Leu Pro Lys Lys Gly Gly Ala Gly Gly Lys Gly Val 
            100                 105                 110         


Trp Gly Thr Pro Gly Gln Val Tyr Asp Val Glu Glu Val Asp Val Lys 
        115                 120                 125             


Asp Pro Asn Tyr Asp Asp Asp Gln Glu Asn Cys Val Tyr Glu Thr Val 
    130                 135                 140                 


Val Leu Pro Leu Asp Glu Arg Ala Phe Glu Lys Thr Leu Thr Pro Ile 
145                 150                 155                 160 


Ile Gln Glu Tyr Phe Glu His Gly Asp Thr Asn Glu Val Ala Glu Met 
                165                 170                 175     


Leu Arg Asp Leu Asn Leu Gly Glu Met Lys Ser Gly Val Pro Val Leu 
            180                 185                 190         


Ala Val Ser Leu Ala Leu Glu Gly Lys Ala Ser His Arg Glu Met Thr 
        195                 200                 205             


Ser Lys Leu Leu Ser Asp Leu Cys Gly Thr Val Met Ser Thr Thr Asp 
    210                 215                 220                 


Val Glu Lys Ser Phe Asp Lys Leu Leu Lys Asp Leu Pro Glu Leu Ala 
225                 230                 235                 240 


Leu Asp Thr Pro Arg Ala Pro Gln Leu Val Gly Gln Phe Ile Ala Arg 
                245                 250                 255     


Ala Val Gly Asp Gly Ile Leu Cys Asn Thr Tyr Ile Asp Ser Tyr Lys 
            260                 265                 270         


Gly Thr Val Asp Cys Val Gln Ala Arg Ala Ala Leu Asp Lys Ala Thr 
        275                 280                 285             


Val Leu Leu Ser Met Ser Lys Gly Gly Lys Arg Lys Asp Ser Val Trp 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gln Gln Ser Val Asn His Leu Val Lys Glu Ile 
305                 310                 315                 320 


Asp Met Leu Leu Lys Glu Tyr Leu Leu Ser Gly Asp Ile Ser Glu Ala 
                325                 330                 335     


Glu His Cys Leu Lys Glu Leu Glu Val Pro His Phe His His Glu Leu 
            340                 345                 350         


Val Tyr Glu Ala Ile Ile Met Val Leu Glu Ser Thr Gly Glu Ser Thr 
        355                 360                 365             


Phe Lys Met Ile Leu Asp Leu Leu Lys Ser Leu Trp Lys Ser Ser Thr 
    370                 375                 380                 


Ile Thr Val Asp Gln Met Lys Arg Gly Tyr Glu Arg Ile Tyr Asn Glu 
385                 390                 395                 400 


Ile Pro Asp Ile Asn Leu Asp Val Pro His Ser Tyr Ser Val Leu Glu 
                405                 410                 415     


Arg Phe Val Glu Glu Cys Phe Gln Ala Gly Ile Ile Ser Lys Gln Leu 
            420                 425                 430         


Arg Asp Leu Cys Pro Ser Arg Gly Arg Lys Arg Phe Val Ser Glu Gly 
        435                 440                 445             


Asp Gly Gly Arg Leu Lys Pro Glu Ser Tyr 
    450                 455             


<210>  51
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Val Leu Cys Phe Pro Leu Leu Leu Leu Leu Leu Val Leu Trp Gly 
1               5                   10                  15      


Pro Val Cys Pro Leu His Ala Trp Pro Lys Arg Leu Thr Lys Ala His 
            20                  25                  30          


Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro Leu Gln Cys Asn Arg 
        35                  40                  45              


Ala Met Ser Gly Ile Asn Asn Tyr Thr Gln His Cys Lys His Gln Asn 
    50                  55                  60                  


Thr Phe Leu His Asp Ser Phe Gln Asn Val Ala Ala Val Cys Asp Leu 
65                  70                  75                  80  


Leu Ser Ile Val Cys Lys Asn Arg Arg His Asn Cys His Gln Ser Ser 
                85                  90                  95      


Lys Pro Val Asn Met Thr Asp Cys Arg Leu Thr Ser Gly Lys Tyr Pro 
            100                 105                 110         


Gln Cys Arg Tyr Ser Ala Ala Ala Gln Tyr Lys Phe Phe Ile Val Ala 
        115                 120                 125             


Cys Asp Pro Pro Gln Lys Ser Asp Pro Pro Tyr Lys Leu Val Pro Val 
    130                 135                 140                 


His Leu Asp Ser Ile Leu 
145                 150 


<210>  52
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Arg Pro Ala Ala Leu Arg Gly Ala Leu Leu Gly Cys Leu Cys Leu 
1               5                   10                  15      


Ala Leu Leu Cys Leu Gly Gly Ala Asp Lys Arg Leu Arg Asp Asn His 
            20                  25                  30          


Glu Trp Lys Lys Leu Ile Met Val Gln His Trp Pro Glu Thr Val Cys 
        35                  40                  45              


Glu Lys Ile Gln Asn Asp Cys Arg Asp Pro Pro Asp Tyr Trp Thr Ile 
    50                  55                  60                  


His Gly Leu Trp Pro Asp Lys Ser Glu Gly Cys Asn Arg Ser Trp Pro 
65                  70                  75                  80  


Phe Asn Leu Glu Glu Ile Lys Asp Leu Leu Pro Glu Met Arg Ala Tyr 
                85                  90                  95      


Trp Pro Asp Val Ile His Ser Phe Pro Asn Arg Ser Arg Phe Trp Lys 
            100                 105                 110         


His Glu Trp Glu Lys His Gly Thr Cys Ala Ala Gln Val Asp Ala Leu 
        115                 120                 125             


Asn Ser Gln Lys Lys Tyr Phe Gly Arg Ser Leu Glu Leu Tyr Arg Glu 
    130                 135                 140                 


Leu Asp Leu Asn Ser Val Leu Leu Lys Leu Gly Ile Lys Pro Ser Ile 
145                 150                 155                 160 


Asn Tyr Tyr Gln Val Ala Asp Phe Lys Asp Ala Leu Ala Arg Val Tyr 
                165                 170                 175     


Gly Val Ile Pro Lys Ile Gln Cys Leu Pro Pro Ser Gln Asp Glu Glu 
            180                 185                 190         


Val Gln Thr Ile Gly Gln Ile Glu Leu Cys Leu Thr Lys Gln Asp Gln 
        195                 200                 205             


Gln Leu Gln Asn Cys Thr Glu Pro Gly Glu Gln Pro Ser Pro Lys Gln 
    210                 215                 220                 


Glu Val Trp Leu Ala Asn Gly Ala Ala Glu Ser Arg Gly Leu Arg Val 
225                 230                 235                 240 


Cys Glu Asp Gly Pro Val Phe Tyr Pro Pro Pro Lys Lys Thr Lys His 
                245                 250                 255     


<210>  53
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Arg Pro Ala Ala Leu Arg Gly Ala Leu Leu Gly Cys Leu Cys Leu 
1               5                   10                  15      


Ala Leu Leu Cys Leu Gly Gly Ala Asp Lys Arg Leu Arg Asp Asn His 
            20                  25                  30          


Glu Trp Lys Lys Leu Ile Met Val Gln His Trp Pro Glu Thr Val Cys 
        35                  40                  45              


Glu Lys Ile Gln Asn Asp Cys Arg Asp Pro Pro Asp Tyr Trp Thr Ile 
    50                  55                  60                  


His Gly Leu Trp Pro Asp Lys Ser Glu Gly Cys Asn Arg Ser Trp Pro 
65                  70                  75                  80  


Phe Asn Leu Glu Glu Ile Lys Lys Asn Trp Met Glu Ile Thr Asp Ser 
                85                  90                  95      


Ser Leu Pro Ser Pro Ser Thr Leu Pro Ile Ile Asn Ile Phe Tyr Ser 
            100                 105                 110         


Val Leu His Leu Leu Gln Leu Met Asn 
        115                 120     


<210>  54
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  55
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Glu Gly Pro Arg Gly Trp Leu Val Leu Cys Val Leu Ala Ile Ser 
1               5                   10                  15      


Leu Ala Ser Met Val Thr Glu Asp Leu Cys Arg Ala Pro Asp Gly Lys 
            20                  25                  30          


Lys Gly Glu Ala Gly Arg Pro Gly Arg Arg Gly Arg Pro Gly Leu Lys 
        35                  40                  45              


Gly Glu Gln Gly Glu Pro Gly Ala Pro Gly Ile Arg Thr Gly Ile Gln 
    50                  55                  60                  


Gly Leu Lys Gly Asp Gln Gly Glu Pro Gly Pro Ser Gly Asn Pro Gly 
65                  70                  75                  80  


Lys Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg Gly Ile 
                85                  90                  95      


Pro Gly Ile Lys Gly Thr Lys Gly Ser Pro Gly Asn Ile Lys Asp Gln 
            100                 105                 110         


Pro Arg Pro Ala Phe Ser Ala Ile Arg Arg Asn Pro Pro Met Gly Gly 
        115                 120                 125             


Asn Val Val Ile Phe Asp Thr Val Ile Thr Asn Gln Glu Glu Pro Tyr 
    130                 135                 140                 


Gln Asn His Ser Gly Arg Phe Val Cys Thr Val Pro Gly Tyr Tyr Tyr 
145                 150                 155                 160 


Phe Thr Phe Gln Val Leu Ser Gln Trp Glu Ile Cys Leu Ser Ile Val 
                165                 170                 175     


Ser Ser Ser Arg Gly Gln Val Arg Arg Ser Leu Gly Phe Cys Asp Thr 
            180                 185                 190         


Thr Asn Lys Gly Leu Phe Gln Val Val Ser Gly Gly Met Val Leu Gln 
        195                 200                 205             


Leu Gln Gln Gly Asp Gln Val Trp Val Glu Lys Asp Pro Lys Lys Gly 
    210                 215                 220                 


His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly Phe Leu 
225                 230                 235                 240 


Ile Phe Pro Ser Ala 
                245 


<210>  56
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ile Pro Ala Val Val Leu Leu Leu Leu Leu Leu Val Glu Gln Ala 
1               5                   10                  15      


Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Ile Leu 
            20                  25                  30          


Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile 
        35                  40                  45              


Gln Val Arg Lys Ala Ala Ile Thr Ser Tyr Glu Lys Ser Asp Gly Val 
    50                  55                  60                  


Tyr Thr Gly Leu Ser Thr Arg Asn Gln Glu Thr Tyr Glu Thr Leu Lys 
65                  70                  75                  80  


His Glu Lys Pro Pro Gln 
                85      


<210>  57
<211>  999
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Glu Pro Arg Ala Ala Ala Ala Gly Glu Pro Glu Pro Pro Ala Ala 
1               5                   10                  15      


Ser Ser Ser Phe Gln Ala Arg Leu Trp Lys Asn Leu Gln Leu Gly Val 
            20                  25                  30          


Gly Arg Ser Lys Gly Gly Gly Gly Gly Arg Ala Gly Gly Pro Glu Arg 
        35                  40                  45              


Arg Thr Ala Asp Thr Pro Ser Pro Ser Pro Pro Pro Pro Val Gly Thr 
    50                  55                  60                  


Gly Asn Ala Pro Ala Arg Gly Ser Gly Ala Gly Ser Arg Trp Ser Gly 
65                  70                  75                  80  


Phe Lys Lys Arg Lys Gln Val Leu Asp Arg Val Phe Ser Ser Ser Gln 
                85                  90                  95      


Pro Asn Leu Cys Cys Ser Ser Pro Glu Pro Leu Glu Pro Gly Gly Ala 
            100                 105                 110         


Gly Arg Ala Glu Gln Gly Ser Thr Leu Arg Arg Arg Ile Arg Glu His 
        115                 120                 125             


Leu Leu Pro Ala Val Lys Gly Pro Ala Ala Ala Ser Gly Ala Ala Gly 
    130                 135                 140                 


Gly Thr Pro Pro Gly Gly Arg Ser Pro Asp Ser Ala Pro Ser Ser Ser 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Leu Ser Ser Ser Pro Gln Pro Pro Pro Arg Gly 
                165                 170                 175     


Asp Arg Ala Arg Asp Glu Gly Ala Arg Arg Gln Gly Pro Gly Ala His 
            180                 185                 190         


Leu Cys His Gln Lys Ser Ser Ser Leu Pro Gly Thr Ala Cys Leu Glu 
        195                 200                 205             


Gln Leu Leu Glu Pro Pro Pro Pro Pro Ala Glu Pro Ala Arg Ser Pro 
    210                 215                 220                 


Ala Glu Ser Arg Ala Pro Glu Thr Gly Glu Glu His Gly Ser Ser Gln 
225                 230                 235                 240 


Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val Pro Leu Ala 
                245                 250                 255     


Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg Gly Gln Ser 
            260                 265                 270         


Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr Val Lys Phe 
        275                 280                 285             


Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile His Lys Asn 
    290                 295                 300                 


Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val Asp His Leu 
305                 310                 315                 320 


Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe Gly Leu Gln 
                325                 330                 335     


Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln Leu Glu Leu 
            340                 345                 350         


Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro His Tyr Pro 
        355                 360                 365             


Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu Thr Pro Lys 
    370                 375                 380                 


Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys Ser Trp Lys 
385                 390                 395                 400 


Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly Ser Tyr Phe 
                405                 410                 415     


Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro Ala Leu Pro 
            420                 425                 430         


Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr Cys Lys Asn 
        435                 440                 445             


Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu His Arg Lys 
    450                 455                 460                 


Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile Glu Gly Arg 
465                 470                 475                 480 


Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro Tyr Val Lys 
                485                 490                 495     


Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met Pro Lys Thr 
            500                 505                 510         


Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu Tyr Glu Glu 
        515                 520                 525             


Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp Ala Gly Lys 
    530                 535                 540                 


Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser Ala Leu Ser 
545                 550                 555                 560 


Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu Gly Glu Gly 
                565                 570                 575     


His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr Val Ser Ile 
            580                 585                 590         


Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu Arg Glu Glu 
        595                 600                 605             


Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn Leu Lys Asp 
    610                 615                 620                 


Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly Leu Met Ala 
625                 630                 635                 640 


Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val Glu Leu Asn 
                645                 650                 655     


Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu 
            660                 665                 670         


Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His Ser Val Leu 
        675                 680                 685             


Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp Phe Leu 
    690                 695                 700                 


Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu Gln Lys 
705                 710                 715                 720 


Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr Lys Gly Val 
                725                 730                 735     


Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys Ala Ser Leu 
            740                 745                 750         


Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu Asn Arg 
        755                 760                 765             


Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met Lys Arg Cys 
    770                 775                 780                 


Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys Phe Asp 
785                 790                 795                 800 


Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu Phe Leu Phe 
                805                 810                 815     


Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val Leu Leu Leu 
            820                 825                 830         


Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys Asp Asn Arg 
        835                 840                 845             


Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu 
    850                 855                 860                 


Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys 
865                 870                 875                 880 


Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp 
                885                 890                 895     


Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr 
            900                 905                 910         


Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr 
        915                 920                 925             


Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly 
    930                 935                 940                 


Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn 
945                 950                 955                 960 


Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val 
                965                 970                 975     


Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys 
            980                 985                 990         


Arg Lys Lys Asn Asn Leu Gly 
        995                 


<210>  58
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Leu Asp Ser Cys Lys Leu Lys Ser Ala Cys Asn Leu Pro Phe Ile 
1               5                   10                  15      


Cys Asn Lys Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val 
            20                  25                  30          


Pro Leu Ala Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg 
        35                  40                  45              


Gly Gln Ser Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr 
    50                  55                  60                  


Val Lys Phe Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile 
65                  70                  75                  80  


His Lys Asn Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val 
                85                  90                  95      


Asp His Leu Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe 
            100                 105                 110         


Gly Leu Gln Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln 
        115                 120                 125             


Leu Glu Leu Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro 
    130                 135                 140                 


His Tyr Pro Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu 
145                 150                 155                 160 


Thr Pro Lys Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys 
                165                 170                 175     


Ser Trp Lys Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly 
            180                 185                 190         


Ser Tyr Phe Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro 
        195                 200                 205             


Ala Leu Pro Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr 
    210                 215                 220                 


Cys Lys Asn Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu 
225                 230                 235                 240 


His Arg Lys Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile 
                245                 250                 255     


Glu Gly Arg Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro 
            260                 265                 270         


Tyr Val Lys Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met 
        275                 280                 285             


Pro Lys Thr Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu 
    290                 295                 300                 


Tyr Glu Glu Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp 
305                 310                 315                 320 


Ala Gly Lys Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser 
                325                 330                 335     


Ala Leu Ser Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu 
            340                 345                 350         


Gly Glu Gly His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr 
        355                 360                 365             


Val Ser Ile Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu 
    370                 375                 380                 


Arg Glu Glu Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn 
385                 390                 395                 400 


Leu Lys Asp Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly 
                405                 410                 415     


Leu Met Ala Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val 
            420                 425                 430         


Glu Leu Asn Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu 
        435                 440                 445             


Asn Pro Glu Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His 
    450                 455                 460                 


Ser Val Leu Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala 
465                 470                 475                 480 


Asp Phe Leu Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly 
                485                 490                 495     


Glu Gln Lys Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr 
            500                 505                 510         


Lys Gly Val Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys 
        515                 520                 525             


Ala Ser Leu Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu 
    530                 535                 540                 


Glu Asn Arg Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met 
545                 550                 555                 560 


Lys Arg Cys Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser 
                565                 570                 575     


Cys Phe Asp Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Leu 
            580                 585                 590         


Phe Leu Phe Val Val Trp Asn Phe Glu Leu Tyr Met Ile Pro Leu Val 
        595                 600                 605             


Leu Leu Leu Leu Leu Thr Trp Asn Tyr Phe Leu Ile Ile Ser Gly Lys 
    610                 615                 620                 


Asp Asn Arg Gln Arg Asp Thr Val Val Glu Asp Met Leu Glu Asp Glu 
625                 630                 635                 640 


Glu Glu Glu Asp Asp Lys Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe 
                645                 650                 655     


Ile Asn Lys Ile Tyr Ala Ile Gln Glu Val Cys Val Ser Val Gln Asn 
            660                 665                 670         


Ile Leu Asp Glu Val Ala Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe 
        675                 680                 685             


Asn Trp Thr Val Pro Phe Leu Ser Trp Leu Ala Ile Val Ala Leu Cys 
    690                 695                 700                 


Val Phe Thr Ala Ile Leu Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu 
705                 710                 715                 720 


Val Trp Gly Ile Asn Lys Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala 
                725                 730                 735     


Ile Asp Asn Asn Glu Leu Leu Asp Phe Leu Ser Arg Val Pro Ser Asp 
            740                 745                 750         


Val Gln Val Val Gln Tyr Gln Glu Leu Lys Pro Asp Pro Ser His Ser 
        755                 760                 765             


Pro Tyr Lys Arg Lys Lys Asn Asn Leu Gly 
    770                 775             


<210>  59
<211>  692
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Leu Asp Ser Cys Lys Leu Lys Ser Ala Cys Asn Leu Pro Phe Ile 
1               5                   10                  15      


Cys Asn Lys Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val 
            20                  25                  30          


Pro Leu Ala Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg 
        35                  40                  45              


Gly Gln Ser Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr 
    50                  55                  60                  


Val Lys Phe Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile 
65                  70                  75                  80  


His Lys Asn Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val 
                85                  90                  95      


Asp His Leu Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe 
            100                 105                 110         


Gly Leu Gln Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln 
        115                 120                 125             


Leu Glu Leu Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro 
    130                 135                 140                 


His Tyr Pro Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu 
145                 150                 155                 160 


Thr Pro Lys Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys 
                165                 170                 175     


Ser Trp Lys Arg Ser Ser Lys Phe Gln Thr Gln Ser Leu Arg Leu Ser 
            180                 185                 190         


Asp Leu His Arg Lys Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr 
        195                 200                 205             


Leu Ile Glu Gly Arg Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser 
    210                 215                 220                 


Asp Pro Tyr Val Lys Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys 
225                 230                 235                 240 


Ile Met Pro Lys Thr Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe 
                245                 250                 255     


His Leu Tyr Glu Glu Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp 
            260                 265                 270         


Lys Asp Ala Gly Lys Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp 
        275                 280                 285             


Leu Ser Ala Leu Ser Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu 
    290                 295                 300                 


Glu Glu Gly Glu Gly His Leu Val Leu Leu Val Thr Leu Thr Ala Ser 
305                 310                 315                 320 


Ala Thr Val Ser Ile Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln 
                325                 330                 335     


Lys Glu Arg Glu Glu Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe 
            340                 345                 350         


His Asn Leu Lys Asp Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala 
        355                 360                 365             


Glu Gly Leu Met Ala Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys 
    370                 375                 380                 


Val Val Glu Leu Asn Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys 
385                 390                 395                 400 


Asn Leu Asn Pro Glu Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp 
                405                 410                 415     


Ile His Ser Val Leu Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg 
            420                 425                 430         


Ser Ala Asp Phe Leu Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln 
        435                 440                 445             


Asn Gly Glu Gln Lys Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly 
    450                 455                 460                 


Pro Thr Lys Gly Val Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala 
465                 470                 475                 480 


Val Lys Ala Ser Leu Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile 
                485                 490                 495     


Glu Glu Glu Asn Arg Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile 
            500                 505                 510         


Arg Met Lys Arg Cys Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val 
        515                 520                 525             


Asn Ser Cys Phe Asp Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe 
    530                 535                 540                 


Val Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu Asp Asp Lys 
545                 550                 555                 560 


Asp Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys Ile Tyr Ala 
                565                 570                 575     


Ile Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp Glu Val Ala 
            580                 585                 590         


Ser Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr Val Pro Phe 
        595                 600                 605             


Leu Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr Ala Ile Leu 
    610                 615                 620                 


Tyr Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly Ile Asn Lys 
625                 630                 635                 640 


Phe Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn Asn Glu Leu 
                645                 650                 655     


Leu Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val Val Gln Tyr 
            660                 665                 670         


Gln Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys Arg Lys Lys 
        675                 680                 685             


Asn Asn Leu Gly 
    690         


<210>  60
<211>  600
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Leu Asp Ser Cys Lys Leu Lys Ser Ala Cys Asn Leu Pro Phe Ile 
1               5                   10                  15      


Cys Asn Lys Lys Ile Ile Asn Thr Ala Gly Thr Ser Asn Ala Glu Val 
            20                  25                  30          


Pro Leu Ala Asp Pro Gly Met Tyr Gln Leu Asp Ile Thr Leu Arg Arg 
        35                  40                  45              


Gly Gln Ser Leu Ala Ala Arg Asp Arg Gly Gly Thr Ser Asp Pro Tyr 
    50                  55                  60                  


Val Lys Phe Lys Ile Gly Gly Lys Glu Val Phe Arg Ser Lys Ile Ile 
65                  70                  75                  80  


His Lys Asn Leu Asn Pro Val Trp Glu Glu Lys Ala Cys Ile Leu Val 
                85                  90                  95      


Asp His Leu Arg Glu Pro Leu Tyr Ile Lys Val Phe Asp Tyr Asp Phe 
            100                 105                 110         


Gly Leu Gln Asp Asp Phe Met Gly Ser Ala Phe Leu Asp Leu Thr Gln 
        115                 120                 125             


Leu Glu Leu Asn Arg Pro Thr Asp Val Thr Leu Thr Leu Lys Asp Pro 
    130                 135                 140                 


His Tyr Pro Asp His Asp Leu Gly Ile Ile Leu Leu Ser Val Ile Leu 
145                 150                 155                 160 


Thr Pro Lys Glu Gly Glu Ser Arg Asp Val Thr Met Leu Met Arg Lys 
                165                 170                 175     


Ser Trp Lys Arg Ser Ser Lys Glu Leu Ser Glu Asn Glu Val Val Gly 
            180                 185                 190         


Ser Tyr Phe Ser Val Lys Ser Leu Phe Trp Arg Thr Cys Gly Arg Pro 
        195                 200                 205             


Ala Leu Pro Val Leu Gly Phe Cys Arg Ala Glu Leu Gln Asn Pro Tyr 
    210                 215                 220                 


Cys Lys Asn Val Gln Phe Gln Thr Gln Ser Leu Arg Leu Ser Asp Leu 
225                 230                 235                 240 


His Arg Lys Ser His Leu Trp Arg Gly Ile Val Ser Ile Thr Leu Ile 
                245                 250                 255     


Glu Gly Arg Asp Leu Lys Ala Met Asp Ser Asn Gly Leu Ser Asp Pro 
            260                 265                 270         


Tyr Val Lys Phe Arg Leu Gly His Gln Lys Tyr Lys Ser Lys Ile Met 
        275                 280                 285             


Pro Lys Thr Leu Asn Pro Gln Trp Arg Glu Gln Phe Asp Phe His Leu 
    290                 295                 300                 


Tyr Glu Glu Arg Gly Gly Val Ile Asp Ile Thr Ala Trp Asp Lys Asp 
305                 310                 315                 320 


Ala Gly Lys Arg Asp Asp Phe Ile Gly Arg Cys Gln Val Asp Leu Ser 
                325                 330                 335     


Ala Leu Ser Arg Glu Gln Thr His Lys Leu Glu Leu Gln Leu Glu Glu 
            340                 345                 350         


Gly Glu Gly His Leu Val Leu Leu Val Thr Leu Thr Ala Ser Ala Thr 
        355                 360                 365             


Val Ser Ile Ser Asp Leu Ser Val Asn Ser Leu Glu Asp Gln Lys Glu 
    370                 375                 380                 


Arg Glu Glu Ile Leu Lys Arg Tyr Ser Pro Leu Arg Ile Phe His Asn 
385                 390                 395                 400 


Leu Lys Asp Val Gly Phe Leu Gln Val Lys Val Ile Arg Ala Glu Gly 
                405                 410                 415     


Leu Met Ala Ala Asp Val Thr Gly Lys Ser Asp Pro Phe Cys Val Val 
            420                 425                 430         


Glu Leu Asn Asn Asp Arg Leu Leu Thr His Thr Val Tyr Lys Asn Leu 
        435                 440                 445             


Asn Pro Glu Trp Asn Lys Val Phe Thr Phe Asn Ile Lys Asp Ile His 
    450                 455                 460                 


Ser Val Leu Glu Val Thr Val Tyr Asp Glu Asp Arg Asp Arg Ser Ala 
465                 470                 475                 480 


Asp Phe Leu Gly Lys Val Ala Ile Pro Leu Leu Ser Ile Gln Asn Gly 
                485                 490                 495     


Glu Gln Lys Ala Tyr Val Leu Lys Asn Lys Gln Leu Thr Gly Pro Thr 
            500                 505                 510         


Lys Gly Val Ile Tyr Leu Glu Ile Asp Val Ile Phe Asn Ala Val Lys 
        515                 520                 525             


Ala Ser Leu Arg Thr Leu Ile Pro Lys Glu Gln Lys Tyr Ile Glu Glu 
    530                 535                 540                 


Glu Asn Arg Leu Ser Lys Gln Leu Leu Leu Arg Asn Phe Ile Arg Met 
545                 550                 555                 560 


Lys Arg Cys Val Met Val Leu Val Asn Ala Ala Tyr Tyr Val Asn Ser 
                565                 570                 575     


Cys Phe Asp Trp Asp Ser Pro Pro Arg Ser Leu Ala Ala Phe Val Ala 
            580                 585                 590         


Leu Tyr Gly Thr Phe Ile Asn Val 
        595                 600 


<210>  61
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Asp Ser Asn Gly Leu Ser Asp Pro Tyr Val Lys Phe Arg Leu Gly 
1               5                   10                  15      


His Gln Lys Tyr Lys Ser Lys Ile Met Pro Lys Thr Leu Asn Pro Gln 
            20                  25                  30          


Trp Arg Glu Gln Phe Asp Phe His Leu Tyr Glu Glu Arg Gly Gly Val 
        35                  40                  45              


Ile Asp Ile Thr Ala Trp Asp Lys Asp Ala Gly Lys Arg Asp Asp Phe 
    50                  55                  60                  


Ile Gly Arg Cys Gln Val Asp Leu Ser Ala Leu Ser Arg Glu Gln Thr 
65                  70                  75                  80  


His Lys Leu Glu Leu Gln Leu Glu Glu Gly Glu Gly His Leu Val Leu 
                85                  90                  95      


Leu Val Thr Leu Thr Ala Ser Ala Thr Val Ser Ile Ser Asp Leu Ser 
            100                 105                 110         


Val Asn Ser Leu Glu Asp Gln Lys Glu Arg Glu Glu Ile Leu Lys Arg 
        115                 120                 125             


Tyr Ser Pro Leu Arg Ile Phe His Asn Leu Lys Asp Val Gly Phe Leu 
    130                 135                 140                 


Gln Val Lys Val Ile Arg Ala Glu Gly Leu Met Ala Ala Asp Val Thr 
145                 150                 155                 160 


Gly Lys Ser Asp Pro Phe Cys Val Val Glu Leu Asn Asn Asp Arg Leu 
                165                 170                 175     


Leu Thr His Thr Val Tyr Lys Asn Leu Asn Pro Glu Trp Asn Lys Val 
            180                 185                 190         


Phe Thr Phe Asn Ile Lys Asp Ile His Ser Val Leu Glu Val Thr Val 
        195                 200                 205             


Tyr Asp Glu Asp Arg Asp Arg Ser Ala Asp Phe Leu Gly Lys Val Ala 
    210                 215                 220                 


Ile Pro Leu Leu Ser Ile Gln Asn Gly Glu Gln Lys Ala Tyr Val Leu 
225                 230                 235                 240 


Lys Asn Lys Gln Leu Thr Gly Pro Thr Lys Gly Val Ile Tyr Leu Glu 
                245                 250                 255     


Ile Asp Val Ile Phe Asn Ala Val Lys Ala Ser Leu Arg Thr Leu Ile 
            260                 265                 270         


Pro Lys Glu Gln Lys Tyr Ile Glu Glu Glu Asn Arg Leu Ser Lys Gln 
        275                 280                 285             


Leu Leu Leu Arg Asn Phe Ile Arg Met Lys Arg Cys Val Met Val Leu 
    290                 295                 300                 


Val Asn Ala Ala Tyr Tyr Val Asn Ser Cys Phe Asp Trp Asp Ser Pro 
305                 310                 315                 320 


Pro Arg Ser Leu Ala Ala Phe Val Leu Phe Leu Phe Val Val Trp Asn 
                325                 330                 335     


Phe Glu Leu Tyr Met Ile Pro Leu Val Leu Leu Leu Leu Leu Thr Trp 
            340                 345                 350         


Asn Tyr Phe Leu Ile Ile Ser Gly Lys Asp Asn Arg Gln Arg Asp Thr 
        355                 360                 365             


Val Val Glu Asp Met Leu Glu Asp Glu Glu Glu Glu Asp Asp Lys Asp 
    370                 375                 380                 


Asp Lys Asp Ser Glu Lys Lys Gly Phe Ile Asn Lys Ile Tyr Ala Ile 
385                 390                 395                 400 


Gln Glu Val Cys Val Ser Val Gln Asn Ile Leu Asp Glu Val Ala Ser 
                405                 410                 415     


Phe Gly Glu Arg Ile Lys Asn Thr Phe Asn Trp Thr Val Pro Phe Leu 
            420                 425                 430         


Ser Trp Leu Ala Ile Val Ala Leu Cys Val Phe Thr Ala Ile Leu Tyr 
        435                 440                 445             


Cys Ile Pro Leu Arg Tyr Ile Val Leu Val Trp Gly Ile Asn Lys Phe 
    450                 455                 460                 


Thr Lys Lys Leu Arg Ser Pro Tyr Ala Ile Asp Asn Asn Glu Leu Leu 
465                 470                 475                 480 


Asp Phe Leu Ser Arg Val Pro Ser Asp Val Gln Val Val Gln Tyr Gln 
                485                 490                 495     


Glu Leu Lys Pro Asp Pro Ser His Ser Pro Tyr Lys Arg Lys Lys Asn 
            500                 505                 510         


Asn Leu Gly 
        515 


<210>  62
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Leu Pro Leu Leu Leu Leu Pro Leu Leu Trp Gly Gly Ser Leu Gln 
1               5                   10                  15      


Glu Lys Pro Val Tyr Glu Leu Gln Val Gln Lys Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Ser Phe Ser Tyr Pro Trp Arg 
        35                  40                  45              


Ser Trp Tyr Ser Ser Pro Pro Leu Tyr Val Tyr Trp Phe Arg Asp Gly 
    50                  55                  60                  


Glu Ile Pro Tyr Tyr Ala Glu Val Val Ala Thr Asn Asn Pro Asp Arg 
65                  70                  75                  80  


Arg Val Lys Pro Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Val 
                85                  90                  95      


Gln Lys Lys Asn Cys Ser Leu Ser Ile Gly Asp Ala Arg Met Glu Asp 
            100                 105                 110         


Thr Gly Ser Tyr Phe Phe Arg Val Glu Arg Gly Arg Asp Val Lys Tyr 
        115                 120                 125             


Ser Tyr Gln Gln Asn Lys Leu Asn Leu Glu Val Thr Ala Leu Ile Glu 
    130                 135                 140                 


Lys Pro Asp Ile His Phe Leu Glu Pro Leu Glu Ser Gly Arg Pro Thr 
145                 150                 155                 160 


Arg Leu Ser Cys Ser Leu Pro Gly Ser Cys Glu Ala Gly Pro Pro Leu 
                165                 170                 175     


Thr Phe Ser Trp Thr Gly Asn Ala Leu Ser Pro Leu Asp Pro Glu Thr 
            180                 185                 190         


Thr Arg Ser Ser Glu Leu Thr Leu Thr Pro Arg Pro Glu Asp His Gly 
        195                 200                 205             


Thr Asn Leu Thr Cys Gln Met Lys Arg Gln Gly Ala Gln Val Thr Thr 
    210                 215                 220                 


Glu Arg Thr Val Gln Leu Asn Val Ser Tyr Ala Pro Gln Thr Ile Thr 
225                 230                 235                 240 


Ile Phe Arg Asn Gly Ile Ala Leu Glu Ile Leu Gln Asn Thr Ser Tyr 
                245                 250                 255     


Leu Pro Val Leu Glu Gly Gln Ala Leu Arg Leu Leu Cys Asp Ala Pro 
            260                 265                 270         


Ser Asn Pro Pro Ala His Leu Ser Trp Phe Gln Gly Ser Pro Ala Leu 
        275                 280                 285             


Asn Ala Thr Pro Ile Ser Asn Thr Gly Ile Leu Glu Leu Arg Arg Val 
    290                 295                 300                 


Arg Ser Ala Glu Glu Gly Gly Phe Thr Cys Arg Ala Gln His Pro Leu 
305                 310                 315                 320 


Gly Phe Leu Gln Ile Phe Leu Asn Leu Ser Val Tyr Ser Leu Pro Gln 
                325                 330                 335     


Leu Leu Gly Pro Ser Cys Ser Trp Glu Ala Glu Gly Leu His Cys Arg 
            340                 345                 350         


Cys Ser Phe Arg Ala Arg Pro Ala Pro Ser Leu Cys Trp Arg Leu Glu 
        355                 360                 365             


Glu Lys Pro Leu Glu Gly Asn Ser Ser Gln Gly Ser Phe Lys Val Asn 
    370                 375                 380                 


Ser Ser Ser Ala Gly Pro Trp Ala Asn Ser Ser Leu Ile Leu His Gly 
385                 390                 395                 400 


Gly Leu Ser Ser Asp Leu Lys Val Ser Cys Lys Ala Trp Asn Ile Tyr 
                405                 410                 415     


Gly Ser Gln Ser Gly Ser Val Leu Leu Leu Gln Gly Arg Ser Asn Leu 
            420                 425                 430         


Gly Thr Gly Val Val Pro Ala Ala Leu Gly Gly Ala Gly Val Met Ala 
        435                 440                 445             


Leu Leu Cys Ile Cys Leu Cys Leu Ile Phe Phe Leu Ile Val Lys Ala 
    450                 455                 460                 


Arg Arg Lys Gln Ala Ala Gly Arg Pro Glu Lys Met Asp Asp Glu Asp 
465                 470                 475                 480 


Pro Ile Met Gly Thr Ile Thr Ser Gly Ser Arg Lys Lys Pro Trp Pro 
                485                 490                 495     


Asp Ser Pro Gly Asp Gln Ala Ser Pro Pro Gly Asp Ala Pro Pro Leu 
            500                 505                 510         


Glu Glu Gln Lys Glu Leu His Tyr Ala Ser Leu Ser Phe Ser Glu Met 
        515                 520                 525             


Lys Ser Arg Glu Pro Lys Asp Gln Glu Ala Pro Ser Thr Thr Glu Tyr 
    530                 535                 540                 


Ser Glu Ile Lys Thr Ser Lys 
545                 550     


<210>  63
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Glu Val Thr Ala Asp Gln Pro Arg Trp Val Ser His His His Pro 
1               5                   10                  15      


Ala Val Leu Asn Gly Gln His Pro Asp Thr His His Pro Gly Leu Ser 
            20                  25                  30          


His Ser Tyr Met Asp Ala Ala Gln Tyr Pro Leu Pro Glu Glu Val Asp 
        35                  40                  45              


Val Leu Phe Asn Ile Asp Gly Gln Gly Asn His Val Pro Pro Tyr Tyr 
    50                  55                  60                  


Gly Asn Ser Val Arg Ala Thr Val Gln Arg Tyr Pro Pro Thr His His 
65                  70                  75                  80  


Gly Ser Gln Val Cys Arg Pro Pro Leu Leu His Gly Ser Leu Pro Trp 
                85                  90                  95      


Leu Asp Gly Gly Lys Ala Leu Gly Ser His His Thr Ala Ser Pro Trp 
            100                 105                 110         


Asn Leu Ser Pro Phe Ser Lys Thr Ser Ile His His Gly Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Val Tyr Pro Pro Ala Ser Ser Ser Ser Leu Ser Gly Gly 
    130                 135                 140                 


His Ala Ser Pro His Leu Phe Thr Phe Pro Pro Thr Pro Pro Lys Asp 
145                 150                 155                 160 


Val Ser Pro Asp Pro Ser Leu Ser Thr Pro Gly Ser Ala Gly Ser Ala 
                165                 170                 175     


Arg Gln Asp Glu Lys Glu Cys Leu Lys Tyr Gln Val Pro Leu Pro Asp 
            180                 185                 190         


Ser Met Lys Leu Glu Ser Ser His Ser Arg Gly Ser Met Thr Ala Leu 
        195                 200                 205             


Gly Gly Ala Ser Ser Ser Thr His His Pro Ile Thr Thr Tyr Pro Pro 
    210                 215                 220                 


Tyr Val Pro Glu Tyr Ser Ser Gly Leu Phe Pro Pro Ser Ser Leu Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Thr Gly Phe Gly Cys Lys Ser Arg Pro Lys Ala Arg 
                245                 250                 255     


Ser Ser Thr Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ser Thr Pro 
            260                 265                 270         


Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys Gly 
        275                 280                 285             


Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro Lys 
    290                 295                 300                 


Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Ser Cys Ala Asn Cys 
305                 310                 315                 320 


Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp Pro 
                325                 330                 335     


Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Ile Asn Arg 
            340                 345                 350         


Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys Met 
        355                 360                 365             


Ser Ser Lys Ser Lys Lys Cys Lys Lys Val His Asp Ser Leu Glu Asp 
    370                 375                 380                 


Phe Pro Lys Asn Ser Ser Phe Asn Pro Ala Ala Leu Ser Arg His Met 
385                 390                 395                 400 


Ser Ser Leu Ser His Ile Ser Pro Phe Ser His Ser Ser His Met Leu 
                405                 410                 415     


Thr Thr Pro Thr Pro Met His Pro Pro Ser Ser Leu Ser Phe Gly Pro 
            420                 425                 430         


His His Pro Ser Ser Met Val Thr Ala Met Gly 
        435                 440             


<210>  64
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Glu Val Thr Ala Asp Gln Pro Arg Trp Val Ser His His His Pro 
1               5                   10                  15      


Ala Val Leu Asn Gly Gln His Pro Asp Thr His His Pro Gly Leu Ser 
            20                  25                  30          


His Ser Tyr Met Asp Ala Ala Gln Tyr Pro Leu Pro Glu Glu Val Asp 
        35                  40                  45              


Val Leu Phe Asn Ile Asp Gly Gln Gly Asn His Val Pro Pro Tyr Tyr 
    50                  55                  60                  


Gly Asn Ser Val Arg Ala Thr Val Gln Arg Tyr Pro Pro Thr His His 
65                  70                  75                  80  


Gly Ser Gln Val Cys Arg Pro Pro Leu Leu His Gly Ser Leu Pro Trp 
                85                  90                  95      


Leu Asp Gly Gly Lys Ala Leu Gly Ser His His Thr Ala Ser Pro Trp 
            100                 105                 110         


Asn Leu Ser Pro Phe Ser Lys Thr Ser Ile His His Gly Ser Pro Gly 
        115                 120                 125             


Pro Leu Ser Val Tyr Pro Pro Ala Ser Ser Ser Ser Leu Ser Gly Gly 
    130                 135                 140                 


His Ala Ser Pro His Leu Phe Thr Phe Pro Pro Thr Pro Pro Lys Asp 
145                 150                 155                 160 


Val Ser Pro Asp Pro Ser Leu Ser Thr Pro Gly Ser Ala Gly Ser Ala 
                165                 170                 175     


Arg Gln Asp Glu Lys Glu Cys Leu Lys Tyr Gln Val Pro Leu Pro Asp 
            180                 185                 190         


Ser Met Lys Leu Glu Ser Ser His Ser Arg Gly Ser Met Thr Ala Leu 
        195                 200                 205             


Gly Gly Ala Ser Ser Ser Thr His His Pro Ile Thr Thr Tyr Pro Pro 
    210                 215                 220                 


Tyr Val Pro Glu Tyr Ser Ser Gly Leu Phe Pro Pro Ser Ser Leu Leu 
225                 230                 235                 240 


Gly Gly Ser Pro Thr Gly Phe Gly Cys Lys Ser Arg Pro Lys Ala Arg 
                245                 250                 255     


Ser Ser Thr Glu Gly Arg Glu Cys Val Asn Cys Gly Ala Thr Ser Thr 
            260                 265                 270         


Pro Leu Trp Arg Arg Asp Gly Thr Gly His Tyr Leu Cys Asn Ala Cys 
        275                 280                 285             


Gly Leu Tyr His Lys Met Asn Gly Gln Asn Arg Pro Leu Ile Lys Pro 
    290                 295                 300                 


Lys Arg Arg Leu Ser Ala Ala Arg Arg Ala Gly Thr Ser Cys Ala Asn 
305                 310                 315                 320 


Cys Gln Thr Thr Thr Thr Thr Leu Trp Arg Arg Asn Ala Asn Gly Asp 
                325                 330                 335     


Pro Val Cys Asn Ala Cys Gly Leu Tyr Tyr Lys Leu His Asn Ile Asn 
            340                 345                 350         


Arg Pro Leu Thr Met Lys Lys Glu Gly Ile Gln Thr Arg Asn Arg Lys 
        355                 360                 365             


Met Ser Ser Lys Ser Lys Lys Cys Lys Lys Val His Asp Ser Leu Glu 
    370                 375                 380                 


Asp Phe Pro Lys Asn Ser Ser Phe Asn Pro Ala Ala Leu Ser Arg His 
385                 390                 395                 400 


Met Ser Ser Leu Ser His Ile Ser Pro Phe Ser His Ser Ser His Met 
                405                 410                 415     


Leu Thr Thr Pro Thr Pro Met His Pro Pro Ser Ser Leu Ser Phe Gly 
            420                 425                 430         


Pro His His Pro Ser Ser Met Val Thr Ala Met Gly 
        435                 440                 


<210>  65
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Glu Gly Asp Gly Gly Thr Pro Trp Ala Leu Ala Leu Leu Arg Thr 
1               5                   10                  15      


Phe Asp Ala Gly Glu Phe Thr Gly Trp Glu Lys Val Gly Ser Gly Gly 
            20                  25                  30          


Phe Gly Gln Val Tyr Lys Val Arg His Val His Trp Lys Thr Trp Leu 
        35                  40                  45              


Ala Ile Lys Cys Ser Pro Ser Leu His Val Asp Asp Arg Glu Arg Met 
    50                  55                  60                  


Glu Leu Leu Glu Glu Ala Lys Lys Met Glu Met Ala Lys Phe Arg Tyr 
65                  70                  75                  80  


Ile Leu Pro Val Tyr Gly Ile Cys Arg Glu Pro Val Gly Leu Val Met 
                85                  90                  95      


Glu Tyr Met Glu Thr Gly Ser Leu Glu Lys Leu Leu Ala Ser Glu Pro 
            100                 105                 110         


Leu Pro Trp Asp Leu Arg Phe Arg Ile Ile His Glu Thr Ala Val Gly 
        115                 120                 125             


Met Asn Phe Leu His Cys Met Ala Pro Pro Leu Leu His Leu Asp Leu 
    130                 135                 140                 


Lys Pro Ala Asn Ile Leu Leu Asp Ala His Tyr His Val Lys Ile Ser 
145                 150                 155                 160 


Asp Phe Gly Leu Ala Lys Cys Asn Gly Leu Ser His Ser His Asp Leu 
                165                 170                 175     


Ser Met Asp Gly Leu Phe Gly Thr Ile Ala Tyr Leu Pro Pro Glu Arg 
            180                 185                 190         


Ile Arg Glu Lys Ser Arg Leu Phe Asp Thr Lys His Asp Val Tyr Ser 
        195                 200                 205             


Phe Ala Ile Val Ile Trp Gly Val Leu Thr Gln Lys Lys Pro Phe Ala 
    210                 215                 220                 


Asp Glu Lys Asn Ile Leu His Ile Met Val Lys Val Val Lys Gly His 
225                 230                 235                 240 


Arg Pro Glu Leu Pro Pro Val Cys Arg Ala Arg Pro Arg Ala Cys Ser 
                245                 250                 255     


His Leu Ile Arg Leu Met Gln Arg Cys Trp Gln Gly Asp Pro Arg Val 
            260                 265                 270         


Arg Pro Thr Phe Gln Gly Asn Gly Leu Asn Gly Glu Leu Ile Arg Gln 
        275                 280                 285             


Val Leu Ala Ala Leu Leu Pro Val Thr Gly Arg Trp Arg Ser Pro Gly 
    290                 295                 300                 


Glu Gly Phe Arg Leu Glu Ser Glu Val Ile Ile Arg Val Thr Cys Pro 
305                 310                 315                 320 


Leu Ser Ser Pro Gln Glu Ile Thr Ser Glu Thr Glu Asp Leu Cys Glu 
                325                 330                 335     


Lys Pro Asp Asp Glu Val Lys Glu Thr Ala His Asp Leu Asp Val Lys 
            340                 345                 350         


Ser Pro Pro Glu Pro Arg Ser Glu Val Val Pro Ala Arg Leu Lys Arg 
        355                 360                 365             


Ala Ser Ala Pro Thr Phe Asp Asn Asp Tyr Ser Leu Ser Glu Leu Leu 
    370                 375                 380                 


Ser Gln Leu Asp Ser Gly Val Ser Gln Ala Val Glu Gly Pro Glu Glu 
385                 390                 395                 400 


Leu Ser Arg Ser Ser Ser Glu Ser Lys Leu Pro Ser Ser Gly Ser Gly 
                405                 410                 415     


Lys Arg Leu Ser Gly Val Ser Ser Val Asp Ser Ala Phe Ser Ser Arg 
            420                 425                 430         


Gly Ser Leu Ser Leu Ser Phe Glu Arg Glu Pro Ser Thr Ser Asp Leu 
        435                 440                 445             


Gly Thr Thr Asp Val Gln Lys Lys Lys Leu Val Asp Ala Ile Val Ser 
    450                 455                 460                 


Gly Asp Thr Ser Lys Leu Met Lys Ile Leu Gln Pro Gln Asp Val Asp 
465                 470                 475                 480 


Leu Ala Leu Asp Ser Gly Ala Ser Leu Leu His Leu Ala Val Glu Ala 
                485                 490                 495     


Gly Gln Glu Glu Cys Ala Lys Trp Leu Leu Leu Asn Asn Ala Asn Pro 
            500                 505                 510         


Asn Leu Ser Asn Arg Arg Gly Ser Thr Pro Leu His Met Ala Val Glu 
        515                 520                 525             


Arg Arg Val Arg Gly Val Val Glu Leu Leu Leu Ala Arg Lys Ile Ser 
    530                 535                 540                 


Val Asn Ala Lys Asp Glu Asp Gln Trp Thr Ala Leu His Phe Ala Ala 
545                 550                 555                 560 


Gln Asn Gly Asp Glu Ser Ser Thr Arg Leu Leu Leu Glu Lys Asn Ala 
                565                 570                 575     


Ser Val Asn Glu Val Asp Phe Glu Gly Arg Thr Pro Met His Val Ala 
            580                 585                 590         


Cys Gln His Gly Gln Glu Asn Ile Val Arg Ile Leu Leu Arg Arg Gly 
        595                 600                 605             


Val Asp Val Ser Leu Gln Gly Lys Asp Ala Trp Leu Pro Leu His Tyr 
    610                 615                 620                 


Ala Ala Trp Gln Gly His Leu Pro Ile Val Lys Leu Leu Ala Lys Gln 
625                 630                 635                 640 


Pro Gly Val Ser Val Asn Ala Gln Thr Leu Asp Gly Arg Thr Pro Leu 
                645                 650                 655     


His Leu Ala Ala Gln Arg Gly His Tyr Arg Val Ala Arg Ile Leu Ile 
            660                 665                 670         


Asp Leu Cys Ser Asp Val Asn Val Cys Ser Leu Leu Ala Gln Thr Pro 
        675                 680                 685             


Leu His Val Ala Ala Glu Thr Gly His Thr Ser Thr Ala Arg Leu Leu 
    690                 695                 700                 


Leu His Arg Gly Ala Gly Lys Glu Ala Met Thr Ser Asp Gly Tyr Thr 
705                 710                 715                 720 


Ala Leu His Leu Ala Ala Arg Asn Gly His Leu Ala Thr Val Lys Leu 
                725                 730                 735     


Leu Val Glu Glu Lys Ala Asp Val Leu Ala Arg Gly Pro Leu Asn Gln 
            740                 745                 750         


Thr Ala Leu His Leu Ala Ala Ala His Gly His Ser Glu Val Val Glu 
        755                 760                 765             


Glu Leu Val Ser Ala Asp Val Ile Asp Leu Phe Asp Glu Gln Gly Leu 
    770                 775                 780                 


Ser Ala Leu His Leu Ala Ala Gln Gly Arg His Ala Gln Thr Val Glu 
785                 790                 795                 800 


Thr Leu Leu Arg His Gly Ala His Ile Asn Leu Gln Ser Leu Lys Phe 
                805                 810                 815     


Gln Gly Gly His Gly Pro Ala Ala Thr Leu Leu Arg Arg Ser Lys Thr 
            820                 825                 830         


<210>  66
<211>  784
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Glu Gly Asp Gly Gly Thr Pro Trp Ala Leu Ala Leu Leu Arg Thr 
1               5                   10                  15      


Phe Asp Ala Gly Glu Phe Thr Gly Trp Glu Lys Val Gly Ser Gly Gly 
            20                  25                  30          


Phe Gly Gln Val Tyr Lys Val Arg His Val His Trp Lys Thr Trp Leu 
        35                  40                  45              


Ala Ile Lys Cys Ser Pro Ser Leu His Val Asp Asp Arg Glu Arg Met 
    50                  55                  60                  


Glu Leu Leu Glu Glu Ala Lys Lys Met Glu Met Ala Lys Phe Arg Tyr 
65                  70                  75                  80  


Ile Leu Pro Val Tyr Gly Ile Cys Arg Glu Pro Val Gly Leu Val Met 
                85                  90                  95      


Glu Tyr Met Glu Thr Gly Ser Leu Glu Lys Leu Leu Ala Ser Glu Pro 
            100                 105                 110         


Leu Pro Trp Asp Leu Arg Phe Arg Ile Ile His Glu Thr Ala Val Gly 
        115                 120                 125             


Met Asn Phe Leu His Cys Met Ala Pro Pro Leu Leu His Leu Asp Leu 
    130                 135                 140                 


Lys Pro Ala Asn Ile Leu Leu Asp Ala His Tyr His Val Lys Ile Ser 
145                 150                 155                 160 


Asp Phe Gly Leu Ala Lys Cys Asn Gly Leu Ser His Ser His Asp Leu 
                165                 170                 175     


Ser Met Asp Gly Leu Phe Gly Thr Ile Ala Tyr Leu Pro Pro Glu Arg 
            180                 185                 190         


Ile Arg Glu Lys Ser Arg Leu Phe Asp Thr Lys His Asp Val Tyr Ser 
        195                 200                 205             


Phe Ala Ile Val Ile Trp Gly Val Leu Thr Gln Lys Lys Pro Phe Ala 
    210                 215                 220                 


Asp Glu Lys Asn Ile Leu His Ile Met Val Lys Val Val Lys Gly His 
225                 230                 235                 240 


Arg Pro Glu Leu Pro Pro Val Cys Arg Ala Arg Pro Arg Ala Cys Ser 
                245                 250                 255     


His Leu Ile Arg Leu Met Gln Arg Cys Trp Gln Gly Asp Pro Arg Val 
            260                 265                 270         


Arg Pro Thr Phe Gln Glu Ile Thr Ser Glu Thr Glu Asp Leu Cys Glu 
        275                 280                 285             


Lys Pro Asp Asp Glu Val Lys Glu Thr Ala His Asp Leu Asp Val Lys 
    290                 295                 300                 


Ser Pro Pro Glu Pro Arg Ser Glu Val Val Pro Ala Arg Leu Lys Arg 
305                 310                 315                 320 


Ala Ser Ala Pro Thr Phe Asp Asn Asp Tyr Ser Leu Ser Glu Leu Leu 
                325                 330                 335     


Ser Gln Leu Asp Ser Gly Val Ser Gln Ala Val Glu Gly Pro Glu Glu 
            340                 345                 350         


Leu Ser Arg Ser Ser Ser Glu Ser Lys Leu Pro Ser Ser Gly Ser Gly 
        355                 360                 365             


Lys Arg Leu Ser Gly Val Ser Ser Val Asp Ser Ala Phe Ser Ser Arg 
    370                 375                 380                 


Gly Ser Leu Ser Leu Ser Phe Glu Arg Glu Pro Ser Thr Ser Asp Leu 
385                 390                 395                 400 


Gly Thr Thr Asp Val Gln Lys Lys Lys Leu Val Asp Ala Ile Val Ser 
                405                 410                 415     


Gly Asp Thr Ser Lys Leu Met Lys Ile Leu Gln Pro Gln Asp Val Asp 
            420                 425                 430         


Leu Ala Leu Asp Ser Gly Ala Ser Leu Leu His Leu Ala Val Glu Ala 
        435                 440                 445             


Gly Gln Glu Glu Cys Ala Lys Trp Leu Leu Leu Asn Asn Ala Asn Pro 
    450                 455                 460                 


Asn Leu Ser Asn Arg Arg Gly Ser Thr Pro Leu His Met Ala Val Glu 
465                 470                 475                 480 


Arg Arg Val Arg Gly Val Val Glu Leu Leu Leu Ala Arg Lys Ile Ser 
                485                 490                 495     


Val Asn Ala Lys Asp Glu Asp Gln Trp Thr Ala Leu His Phe Ala Ala 
            500                 505                 510         


Gln Asn Gly Asp Glu Ser Ser Thr Arg Leu Leu Leu Glu Lys Asn Ala 
        515                 520                 525             


Ser Val Asn Glu Val Asp Phe Glu Gly Arg Thr Pro Met His Val Ala 
    530                 535                 540                 


Cys Gln His Gly Gln Glu Asn Ile Val Arg Ile Leu Leu Arg Arg Gly 
545                 550                 555                 560 


Val Asp Val Ser Leu Gln Gly Lys Asp Ala Trp Leu Pro Leu His Tyr 
                565                 570                 575     


Ala Ala Trp Gln Gly His Leu Pro Ile Val Lys Leu Leu Ala Lys Gln 
            580                 585                 590         


Pro Gly Val Ser Val Asn Ala Gln Thr Leu Asp Gly Arg Thr Pro Leu 
        595                 600                 605             


His Leu Ala Ala Gln Arg Gly His Tyr Arg Val Ala Arg Ile Leu Ile 
    610                 615                 620                 


Asp Leu Cys Ser Asp Val Asn Val Cys Ser Leu Leu Ala Gln Thr Pro 
625                 630                 635                 640 


Leu His Val Ala Ala Glu Thr Gly His Thr Ser Thr Ala Arg Leu Leu 
                645                 650                 655     


Leu His Arg Gly Ala Gly Lys Glu Ala Met Thr Ser Asp Gly Tyr Thr 
            660                 665                 670         


Ala Leu His Leu Ala Ala Arg Asn Gly His Leu Ala Thr Val Lys Leu 
        675                 680                 685             


Leu Val Glu Glu Lys Ala Asp Val Leu Ala Arg Gly Pro Leu Asn Gln 
    690                 695                 700                 


Thr Ala Leu His Leu Ala Ala Ala His Gly His Ser Glu Val Val Glu 
705                 710                 715                 720 


Glu Leu Val Ser Ala Asp Val Ile Asp Leu Phe Asp Glu Gln Gly Leu 
                725                 730                 735     


Ser Ala Leu His Leu Ala Ala Gln Gly Arg His Ala Gln Thr Val Glu 
            740                 745                 750         


Thr Leu Leu Arg His Gly Ala His Ile Asn Leu Gln Ser Leu Lys Phe 
        755                 760                 765             


Gln Gly Gly His Gly Pro Ala Ala Thr Leu Leu Arg Arg Ser Lys Thr 
    770                 775                 780                 


<210>  67
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Gly Phe Gln Lys Phe Ser Pro Phe Leu Ala Leu Ser Ile Leu Val 
1               5                   10                  15      


Leu Leu Gln Ala Gly Ser Leu His Ala Ala Pro Phe Arg Ser Ala Leu 
            20                  25                  30          


Glu Ser Ser Pro Ala Asp Pro Ala Thr Leu Ser Glu Asp Glu Ala Arg 
        35                  40                  45              


Leu Leu Leu Ala Ala Leu Val Gln Asn Tyr Val Gln Met Lys Ala Ser 
    50                  55                  60                  


Glu Leu Glu Gln Glu Gln Glu Arg Glu Gly Ser Arg Ile Ile Ala Gln 
65                  70                  75                  80  


Lys Arg Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly 
                85                  90                  95      


Leu Leu Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr 
            100                 105                 110         


Asn Val Gly Ser Lys Ala Phe Gly Arg Arg Arg Arg Asp Leu Gln Ala 
        115                 120                 125             


<210>  68
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Thr 
    50                  55                  60                  


Arg Arg Gly Ser Pro Ala Val Thr Leu Val Gln Leu Pro Ser Gly Gln 
65                  70                  75                  80  


Thr Ile His Val Gln Gly Val Ile Gln Thr Pro Gln Pro Trp Val Ile 
                85                  90                  95      


Gln Ser Ser Glu Ile His Thr Val Gln Val Ala Ala Ile Ala Glu Thr 
            100                 105                 110         


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
        115                 120                 125             


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
    130                 135                 140                 


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
145                 150                 155                 160 


Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser 
                165                 170                 175     


Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly 
            180                 185                 190         


Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln 
        195                 200                 205             


Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile 
    210                 215                 220                 


Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val 
225                 230                 235                 240 


Pro Gly Ser Gln Val Val Val Gln Asp Glu Glu Thr Glu Leu Ala Pro 
                245                 250                 255     


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
            260                 265                 270         


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        275                 280                 285             


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
    290                 295                 300                 


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
305                 310                 315                 320 


Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                325                 330                 335     


Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
            340                 345                 350         


Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        355                 360     


<210>  69
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Thr 
    50                  55                  60                  


Arg Arg Gly Ser Pro Ala Val Thr Leu Val Gln Leu Pro Ser Gly Gln 
65                  70                  75                  80  


Thr Ile His Val Gln Gly Val Ile Gln Thr Pro Gln Pro Trp Val Ile 
                85                  90                  95      


Gln Ser Ser Glu Ile His Thr Val Gln Val Ala Ala Ile Ala Glu Thr 
            100                 105                 110         


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
        115                 120                 125             


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
    130                 135                 140                 


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
145                 150                 155                 160 


Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser 
                165                 170                 175     


Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly 
            180                 185                 190         


Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln 
        195                 200                 205             


Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile 
    210                 215                 220                 


Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val 
225                 230                 235                 240 


Pro Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr 
                245                 250                 255     


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
            260                 265                 270         


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        275                 280                 285             


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    290                 295                 300                 


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
305                 310                 315                 320 


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
                325                 330                 335     


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
            340                 345                 


<210>  70
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Thr 
    50                  55                  60                  


Arg Arg Gly Ser Pro Ala Val Thr Leu Val Gln Leu Pro Ser Gly Gln 
65                  70                  75                  80  


Thr Ile His Val Gln Gly Val Ile Gln Thr Pro Gln Pro Trp Val Ile 
                85                  90                  95      


Gln Ser Ser Glu Ile His Thr Val Gln Val Ala Ala Ile Ala Glu Thr 
            100                 105                 110         


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
        115                 120                 125             


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
    130                 135                 140                 


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
145                 150                 155                 160 


Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser 
                165                 170                 175     


Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly 
            180                 185                 190         


Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln 
        195                 200                 205             


Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile 
    210                 215                 220                 


Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val 
225                 230                 235                 240 


Pro Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr 
                245                 250                 255     


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
            260                 265                 270         


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        275                 280                 285             


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    290                 295                 300                 


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
305                 310                 315                 320 


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu 
                325                 330                 335     


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            340                 345             


<210>  71
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125             


Tyr Gln Thr Ser Thr Gly Gln Tyr Thr Ala Thr Gly Asp Met Pro Thr 
    130                 135                 140                 


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
145                 150                 155                 160 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
                165                 170                 175     


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
            180                 185                 190         


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
        195                 200                 205             


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
    210                 215                 220                 


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
225                 230                 235         


<210>  72
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Val Ala Ala Ile Ala Glu Thr Asp Glu Ser Ala Glu Ser Glu Gly 
1               5                   10                  15      


Val Ile Asp Ser His Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser 
            20                  25                  30          


Tyr Arg Lys Ile Leu Asn Glu Leu Ser Ser Asp Val Pro Gly Val Pro 
        35                  40                  45              


Lys Ile Glu Glu Glu Arg Ser Glu Glu Glu Gly Thr Pro Pro Ser Ile 
    50                  55                  60                  


Ala Thr Met Ala Val Pro Thr Ser Ile Tyr Gln Thr Ser Thr Gly Gln 
65                  70                  75                  80  


Tyr Ile Ala Ile Ala Gln Gly Gly Thr Ile Gln Ile Ser Asn Pro Gly 
                85                  90                  95      


Ser Asp Gly Val Gln Gly Leu Gln Ala Leu Thr Met Thr Asn Ser Gly 
            100                 105                 110         


Ala Pro Pro Pro Gly Ala Thr Ile Val Gln Tyr Ala Ala Gln Ser Ala 
        115                 120                 125             


Asp Gly Thr Gln Gln Phe Phe Val Pro Gly Ser Gln Val Val Val Gln 
    130                 135                 140                 


Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala 
145                 150                 155                 160 


Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His 
                165                 170                 175     


Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg 
            180                 185                 190         


Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys 
        195                 200                 205             


Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln 
    210                 215                 220                 


Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser 
225                 230                 235                 240 


Pro Lys Thr Asp Tyr 
                245 


<210>  73
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ala Val Thr Gly Asp Asp Thr Asp Glu Glu Thr Glu Leu Ala Pro 
1               5                   10                  15      


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
            20                  25                  30          


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        35                  40                  45              


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
    50                  55                  60                  


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg 
65                  70                  75                  80  


Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val 
                85                  90                  95      


Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys 
            100                 105                 110         


Asp Leu Tyr Cys His Lys Val Glu 
        115                 120 


<210>  74
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ala Val Thr Gly Asp Asp Thr Ala Ala Thr Gly Asp Met Pro Thr 
1               5                   10                  15      


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
            20                  25                  30          


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        35                  40                  45              


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    50                  55                  60                  


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
65                  70                  75                  80  


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu 
                85                  90                  95      


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            100                 105             


<210>  75
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Val Thr Gly Asp Asp Thr Asp Glu Glu Thr Glu Leu Ala Pro 
1               5                   10                  15      


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
            20                  25                  30          


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
        35                  40                  45              


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
    50                  55                  60                  


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg 
65                  70                  75                  80  


Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val 
                85                  90                  95      


Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys 
            100                 105                 110         


Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        115                 120     


<210>  76
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Val Thr Gly Asp Asp Thr Ala Ala Thr Gly Asp Met Pro Thr 
1               5                   10                  15      


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
            20                  25                  30          


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
        35                  40                  45              


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
    50                  55                  60                  


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
65                  70                  75                  80  


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
                85                  90                  95      


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
            100                 105                 


<210>  77
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30          


Thr Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45              


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60                  


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr 
                85                  90                  95      


Ser Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly 
            100                 105                 110         


Gly Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu 
        115                 120                 125             


Gln Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr 
    130                 135                 140                 


Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe 
145                 150                 155                 160 


Val Pro Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro 
                165                 170                 175     


Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val 
            180                 185                 190         


Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu 
        195                 200                 205             


Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala 
    210                 215                 220                 


Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu 
225                 230                 235                 240 


Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu 
                245                 250                 255     


Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
            260                 265                 270 


<210>  78
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30          


Thr Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45              


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60                  


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr 
                85                  90                  95      


Ser Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Asp Glu Glu Thr Glu Leu 
            100                 105                 110         


Ala Pro Ser His Met Ala Thr Ala Thr Gly Asp Met Pro Thr Tyr Gln 
        115                 120                 125             


Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala 
    130                 135                 140                 


Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr 
145                 150                 155                 160 


Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu 
                165                 170                 175     


Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val 
            180                 185                 190         


Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr 
        195                 200                 205             


Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    210                 215                 


<210>  79
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Val Ala Ala Ile Ala Glu Thr Asp Glu Ser Ala Glu Ser Glu Gly 
1               5                   10                  15      


Val Ile Asp Ser His Lys Arg Arg Glu Ile Leu Ser Arg Arg Pro Ser 
            20                  25                  30          


Tyr Arg Lys Ile Leu Asn Glu Leu Ser Ser Asp Val Pro Gly Val Pro 
        35                  40                  45              


Lys Ile Glu Glu Glu Arg Ser Glu Glu Glu Gly Thr Pro Pro Ser Ile 
    50                  55                  60                  


Ala Thr Met Ala Val Pro Thr Ser Ile Tyr Gln Thr Ser Thr Gly Gln 
65                  70                  75                  80  


Tyr Asp Glu Glu Thr Glu Leu Ala Pro Ser His Met Ala Thr Ala Thr 
                85                  90                  95      


Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro 
            100                 105                 110         


Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln 
        115                 120                 125             


Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys 
    130                 135                 140                 


Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val 
145                 150                 155                 160 


Lys Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys 
                165                 170                 175     


Leu Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr 
            180                 185                 190         


Asp Tyr 
        


<210>  80
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125             


Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Thr 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160 


Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile Val 
                165                 170                 175     


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val Pro 
            180                 185                 190         


Gly Ser Gln Val Val Val Gln Asp Glu Glu Thr Glu Leu Ala Pro Ser 
        195                 200                 205             


His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala 
    210                 215                 220                 


Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly 
225                 230                 235                 240 


Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg 
                245                 250                 255     


Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys Arg Arg 
            260                 265                 270         


Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala Val Leu 
        275                 280                 285             


Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu Lys Asp 
    290                 295                 300                 


Ile Cys Ser Pro Lys Thr Asp Tyr 
305                 310         


<210>  81
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125             


Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Thr 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160 


Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile Val 
                165                 170                 175     


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val Pro 
            180                 185                 190         


Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr Tyr 
        195                 200                 205             


Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala 
    210                 215                 220                 


Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala 
225                 230                 235                 240 


Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys 
                245                 250                 255     


Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg 
            260                 265                 270         


Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu 
        275                 280                 285             


Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    290                 295                 300 


<210>  82
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ile Ala Ile Ala Gln Gly Gly 
    50                  55                  60                  


Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln 
65                  70                  75                  80  


Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile 
                85                  90                  95      


Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val 
            100                 105                 110         


Pro Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr 
        115                 120                 125             


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
    130                 135                 140                 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
145                 150                 155                 160 


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
                165                 170                 175     


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
            180                 185                 190         


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
        195                 200                 205             


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    210                 215                 220     


<210>  83
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Asp Glu Glu Thr Glu Leu Ala 
    50                  55                  60                  


Pro Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile 
65                  70                  75                  80  


Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser 
                85                  90                  95      


Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg 
            100                 105                 110         


Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys 
        115                 120                 125             


Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala 
    130                 135                 140                 


Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu 
145                 150                 155                 160 


Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
                165                 170 


<210>  84
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Thr 
    50                  55                  60                  


Arg Arg Gly Ser Pro Ala Val Thr Leu Val Gln Leu Pro Ser Gly Gln 
65                  70                  75                  80  


Thr Ile His Val Gln Gly Val Ile Gln Thr Pro Gln Pro Trp Val Ile 
                85                  90                  95      


Gln Ser Ser Glu Ile His Thr Val Gln Val Ala Ala Ile Ala Glu Thr 
            100                 105                 110         


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
        115                 120                 125             


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
    130                 135                 140                 


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
145                 150                 155                 160 


Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser 
                165                 170                 175     


Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ala Ala Thr Gly Asp Met Pro 
            180                 185                 190         


Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val 
        195                 200                 205             


Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu 
    210                 215                 220                 


Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala 
225                 230                 235                 240 


Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu 
                245                 250                 255     


Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu 
            260                 265                 270         


Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        275                 280                 285     


<210>  85
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ser Val Ala Gly Ser Gly Thr 
    50                  55                  60                  


Arg Arg Gly Ser Pro Ala Val Thr Leu Val Gln Leu Pro Ser Gly Gln 
65                  70                  75                  80  


Thr Ile His Val Gln Gly Val Ile Gln Thr Pro Gln Pro Trp Val Ile 
                85                  90                  95      


Gln Ser Ser Glu Ile His Thr Val Gln Val Ala Ala Ile Ala Glu Thr 
            100                 105                 110         


Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg 
        115                 120                 125             


Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu 
    130                 135                 140                 


Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu 
145                 150                 155                 160 


Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser 
                165                 170                 175     


Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ala Ala Thr Gly Asp Met Pro 
            180                 185                 190         


Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val 
        195                 200                 205             


Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu 
    210                 215                 220                 


Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala 
225                 230                 235                 240 


Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu 
                245                 250                 255     


Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu 
            260                 265                 270         


Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
        275                 280                 285 


<210>  86
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Trp Trp His Gln His Asn Leu Cys Phe Arg Arg Pro Ile Glu Glu 
1               5                   10                  15      


Asp Tyr Ser Ser Gly Asp Val Glu Glu Lys Val Ala Ala Ile Ala Glu 
            20                  25                  30          


Thr Asp Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg 
        35                  40                  45              


Arg Glu Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu 
    50                  55                  60                  


Leu Ser Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser 
65                  70                  75                  80  


Glu Glu Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr 
                85                  90                  95      


Ser Ile Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly 
            100                 105                 110         


Gly Thr Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu 
        115                 120                 125             


Gln Ala Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr 
    130                 135                 140                 


Ile Val Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe 
145                 150                 155                 160 


Val Pro Gly Ser Gln Val Val Val Gln Asp Glu Glu Thr Glu Leu Ala 
                165                 170                 175     


Pro Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile 
            180                 185                 190         


Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser 
        195                 200                 205             


Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg 
    210                 215                 220                 


Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys 
225                 230                 235                 240 


Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala 
                245                 250                 255     


Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu 
            260                 265                 270         


Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        275                 280         


<210>  87
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro 
1               5                   10                  15      


Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro Gly Ser 
            20                  25                  30          


Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu 
        35                  40                  45              


Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys 
    50                  55                  60                  


Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu 
65                  70                  75                  80  


Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu 
                85                  90                  95      


Tyr Cys His Lys Val Glu 
            100         


<210>  88
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Asn Arg Thr Gln Glu Leu Ser Gly Gln Leu Ser Ala Ala Thr Gly 
1               5                   10                  15      


Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln 
            20                  25                  30          


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        35                  40                  45              


Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    50                  55                  60                  


Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys 
65                  70                  75                  80  


Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu 
                85                  90                  95      


Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
            100                 105                 110         


<210>  89
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
1               5                   10                  15      


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
        35                  40                  45              


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60                  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80  


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95      


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
            100                 105                 110         


Tyr Gln Thr Ser Thr Gly Gln Tyr Ser Met Tyr Ala Ala Ile Arg Tyr 
        115                 120                 125             


Asp Thr Val Leu Ala Leu Ser Leu Leu 
    130                 135         


<210>  90
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125             


Tyr Gln Thr Ser Thr Gly Gln Tyr Asn Glu Glu Thr Glu Leu Ala Pro 
    130                 135                 140                 


Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile Arg 
145                 150                 155                 160 


Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser Pro 
                165                 170                 175     


Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg Lys 
            180                 185                 190         


Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg 
        195                 200                 205             


Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val 
    210                 215                 220                 


Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys 
225                 230                 235                 240 


Asp Leu Tyr Cys His Lys Val Glu 
                245             


<210>  91
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Asn Arg Thr Gln Glu Leu Ser Gly Gln Leu Ser Ala Ala Thr Gly 
1               5                   10                  15      


Asp Met Pro Thr Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln 
            20                  25                  30          


Gly Val Val Met Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln 
        35                  40                  45              


Leu Ala Glu Glu Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn 
    50                  55                  60                  


Arg Glu Ala Ala Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys 
65                  70                  75                  80  


Cys Leu Glu Ser Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu 
                85                  90                  95      


Ile Glu Glu Leu Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp 
            100                 105                 110         


Tyr 
    


<210>  92
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile Val Gln Tyr 
1               5                   10                  15      


Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val Pro Gly Ser 
            20                  25                  30          


Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr Tyr Gln Ile 
        35                  40                  45              


Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala Ala Ser 
    50                  55                  60                  


Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala Thr Arg 
65                  70                  75                  80  


Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Lys Glu Cys 
                85                  90                  95      


Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser Arg Val Ala 
            100                 105                 110         


Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu Glu Thr Leu 
        115                 120                 125             


Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    130                 135             


<210>  93
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Asn Arg Thr Gln Glu Leu Ser Gly Gln Leu Ser Asp Glu Glu Thr 
1               5                   10                  15      


Glu Leu Ala Pro Ser His Met Ala Ala Ala Thr Gly Asp Met Pro Thr 
            20                  25                  30          


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
        35                  40                  45              


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
    50                  55                  60                  


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
65                  70                  75                  80  


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
                85                  90                  95      


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
            100                 105                 110         


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
        115                 120                 125 


<210>  94
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
1               5                   10                  15      


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
            20                  25                  30          


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
        35                  40                  45              


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
    50                  55                  60                  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
65                  70                  75                  80  


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
                85                  90                  95      


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
            100                 105                 110         


Tyr Gln Thr Ser Thr Gly Gln Tyr Thr Ala Thr Gly Asp Met Pro Thr 
        115                 120                 125             


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
    130                 135                 140                 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
145                 150                 155                 160 


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
                165                 170                 175     


Lys Glu Cys Arg Arg Arg Lys Lys Glu Tyr Val Lys Cys Leu Glu Ser 
            180                 185                 190         


Arg Val Ala Val Leu Glu Val Gln Asn Lys Lys Leu Ile Glu Glu Leu 
        195                 200                 205             


Glu Thr Leu Lys Asp Ile Cys Ser Pro Lys Thr Asp Tyr 
    210                 215                 220     


<210>  95
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125             


Tyr Gln Thr Ser Thr Gly Gln Tyr Ile Ala Ile Ala Gln Gly Gly Thr 
    130                 135                 140                 


Ile Gln Ile Ser Asn Pro Gly Ser Asp Gly Val Gln Gly Leu Gln Ala 
145                 150                 155                 160 


Leu Thr Met Thr Asn Ser Gly Ala Pro Pro Pro Gly Ala Thr Ile Val 
                165                 170                 175     


Gln Tyr Ala Ala Gln Ser Ala Asp Gly Thr Gln Gln Phe Phe Val Pro 
            180                 185                 190         


Gly Ser Gln Val Val Val Gln Ala Ala Thr Gly Asp Met Pro Thr Tyr 
        195                 200                 205             


Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met Ala 
    210                 215                 220                 


Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu Ala 
225                 230                 235                 240 


Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala Arg 
                245                 250                 255     


Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg 
            260                 265                 270         


Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys 
        275                 280                 285             


Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
    290                 295                 


<210>  96
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ser Lys Cys Ala Arg Lys Lys Tyr Ile Lys Thr Asn Pro Arg Gln 
1               5                   10                  15      


Met Thr Met Glu Thr Val Glu Ser Gln His Asp Gly Ser Ile Thr Ala 
            20                  25                  30          


Ser Leu Thr Glu Ser Lys Ser Ala His Val Gln Thr Gln Thr Gly Gln 
        35                  40                  45              


Asn Ser Ile Pro Ala Leu Ala Gln Val Ala Ala Ile Ala Glu Thr Asp 
    50                  55                  60                  


Glu Ser Ala Glu Ser Glu Gly Val Ile Asp Ser His Lys Arg Arg Glu 
65                  70                  75                  80  


Ile Leu Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Glu Leu Ser 
                85                  90                  95      


Ser Asp Val Pro Gly Val Pro Lys Ile Glu Glu Glu Arg Ser Glu Glu 
            100                 105                 110         


Glu Gly Thr Pro Pro Ser Ile Ala Thr Met Ala Val Pro Thr Ser Ile 
        115                 120                 125             


Tyr Gln Thr Ser Thr Gly Gln Tyr Thr Ala Thr Gly Asp Met Pro Thr 
    130                 135                 140                 


Tyr Gln Ile Arg Ala Pro Thr Ala Ala Leu Pro Gln Gly Val Val Met 
145                 150                 155                 160 


Ala Ala Ser Pro Gly Ser Leu His Ser Pro Gln Gln Leu Ala Glu Glu 
                165                 170                 175     


Ala Thr Arg Lys Arg Glu Leu Arg Leu Met Lys Asn Arg Glu Ala Ala 
            180                 185                 190         


Arg Glu Cys Arg Arg Lys Lys Lys Glu Tyr Val Lys Cys Leu Glu Asn 
        195                 200                 205             


Arg Val Ala Val Leu Glu Asn Gln Asn Lys Thr Leu Ile Glu Glu Leu 
    210                 215                 220                 


Lys Ala Leu Lys Asp Leu Tyr Cys His Lys Val Glu 
225                 230                 235     


<210>  97
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Gln Trp Thr Ser Leu Leu Leu Leu Ala Gly Leu Phe Ser Leu Ser 
1               5                   10                  15      


Gln Ala Gln Tyr Glu Asp Asp Pro His Trp Trp Phe His Tyr Leu Arg 
            20                  25                  30          


Ser Gln Gln Ser Thr Tyr Tyr Asp Pro Tyr Asp Pro Tyr Pro Tyr Glu 
        35                  40                  45              


Thr Tyr Glu Pro Tyr Pro Tyr Gly Val Asp Glu Gly Pro Ala Tyr Thr 
    50                  55                  60                  


Tyr Gly Ser Pro Ser Pro Pro Asp Pro Arg Asp Cys Pro Gln Glu Cys 
65                  70                  75                  80  


Asp Cys Pro Pro Asn Phe Pro Thr Ala Met Tyr Cys Asp Asn Arg Asn 
                85                  90                  95      


Leu Lys Tyr Leu Pro Phe Val Pro Ser Arg Met Lys Tyr Val Tyr Phe 
            100                 105                 110         


Gln Asn Asn Gln Ile Thr Ser Ile Gln Glu Gly Val Phe Asp Asn Ala 
        115                 120                 125             


Thr Gly Leu Leu Trp Ile Ala Leu His Gly Asn Gln Ile Thr Ser Asp 
    130                 135                 140                 


Lys Val Gly Arg Lys Val Phe Ser Lys Leu Arg His Leu Glu Arg Leu 
145                 150                 155                 160 


Tyr Leu Asp His Asn Asn Leu Thr Arg Met Pro Gly Pro Leu Pro Arg 
                165                 170                 175     


Ser Leu Arg Glu Leu His Leu Asp His Asn Gln Ile Ser Arg Val Pro 
            180                 185                 190         


Asn Asn Ala Leu Glu Gly Leu Glu Asn Leu Thr Ala Leu Tyr Leu Gln 
        195                 200                 205             


His Asn Glu Ile Gln Glu Val Gly Ser Ser Met Arg Gly Leu Arg Ser 
    210                 215                 220                 


Leu Ile Leu Leu Asp Leu Ser Tyr Asn His Leu Arg Lys Val Pro Asp 
225                 230                 235                 240 


Gly Leu Pro Ser Ala Leu Glu Gln Leu Tyr Met Glu His Asn Asn Val 
                245                 250                 255     


Tyr Thr Val Pro Asp Ser Tyr Phe Arg Gly Ala Pro Lys Leu Leu Tyr 
            260                 265                 270         


Val Arg Leu Ser His Asn Ser Leu Thr Asn Asn Gly Leu Ala Ser Asn 
        275                 280                 285             


Thr Phe Asn Ser Ser Ser Leu Leu Glu Leu Asp Leu Ser Tyr Asn Gln 
    290                 295                 300                 


Leu Gln Lys Ile Pro Pro Val Asn Thr Asn Leu Glu Asn Leu Tyr Leu 
305                 310                 315                 320 


Gln Gly Asn Arg Ile Asn Glu Phe Ser Ile Ser Ser Phe Cys Thr Val 
                325                 330                 335     


Val Asp Val Val Asn Phe Ser Lys Leu Gln Val Leu Arg Leu Asp Gly 
            340                 345                 350         


Asn Glu Ile Lys Arg Ser Ala Met Pro Ala Asp Ala Pro Leu Cys Leu 
        355                 360                 365             


Arg Leu Ala Ser Leu Ile Glu Ile 
    370                 375     


<210>  98
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Glu Pro Ser Ala Thr Pro Gly Ala Gln Met Gly Val Pro Pro Gly 
1               5                   10                  15      


Ser Arg Glu Pro Ser Pro Val Pro Pro Asp Tyr Glu Asp Glu Phe Leu 
            20                  25                  30          


Arg Tyr Leu Trp Arg Asp Tyr Leu Tyr Pro Lys Gln Tyr Glu Trp Val 
        35                  40                  45              


Leu Ile Ala Ala Tyr Val Ala Val Phe Val Val Ala Leu Val Gly Asn 
    50                  55                  60                  


Thr Leu Val Cys Leu Ala Val Trp Arg Asn His His Met Arg Thr Val 
65                  70                  75                  80  


Thr Asn Tyr Phe Ile Val Asn Leu Ser Leu Ala Asp Val Leu Val Thr 
                85                  90                  95      


Ala Ile Cys Leu Pro Ala Ser Leu Leu Val Asp Ile Thr Glu Ser Trp 
            100                 105                 110         


Leu Phe Gly His Ala Leu Cys Lys Val Ile Pro Tyr Leu Gln Ala Val 
        115                 120                 125             


Ser Val Ser Val Ala Val Leu Thr Leu Ser Phe Ile Ala Leu Asp Arg 
    130                 135                 140                 


Trp Tyr Ala Ile Cys His Pro Leu Leu Phe Lys Ser Thr Ala Arg Arg 
145                 150                 155                 160 


Ala Arg Gly Ser Ile Leu Gly Ile Trp Ala Val Ser Leu Ala Ile Met 
                165                 170                 175     


Val Pro Gln Ala Ala Val Met Glu Cys Ser Ser Val Leu Pro Glu Leu 
            180                 185                 190         


Ala Asn Arg Thr Arg Leu Phe Ser Val Cys Asp Glu Arg Trp Ala Asp 
        195                 200                 205             


Asp Leu Tyr Pro Lys Ile Tyr His Ser Cys Phe Phe Ile Val Thr Tyr 
    210                 215                 220                 


Leu Ala Pro Leu Gly Leu Met Ala Met Ala Tyr Phe Gln Ile Phe Arg 
225                 230                 235                 240 


Lys Leu Trp Gly Arg Gln Ile Pro Gly Thr Thr Ser Ala Leu Val Arg 
                245                 250                 255     


Asn Trp Lys Arg Pro Ser Asp Gln Leu Gly Asp Leu Glu Gln Gly Leu 
            260                 265                 270         


Ser Gly Glu Pro Gln Pro Arg Ala Arg Ala Phe Leu Ala Glu Val Lys 
        275                 280                 285             


Gln Met Arg Ala Arg Arg Lys Thr Ala Lys Met Leu Met Val Val Leu 
    290                 295                 300                 


Leu Val Phe Ala Leu Cys Tyr Leu Pro Ile Ser Val Leu Asn Val Leu 
305                 310                 315                 320 


Lys Arg Val Phe Gly Met Phe Arg Gln Ala Ser Asp Arg Glu Ala Val 
                325                 330                 335     


Tyr Ala Cys Phe Thr Phe Ser His Trp Leu Val Tyr Ala Asn Ser Ala 
            340                 345                 350         


Ala Asn Pro Ile Ile Tyr Asn Phe Leu Ser Gly Lys Phe Arg Glu Gln 
        355                 360                 365             


Phe Lys Ala Ala Phe Ser Cys Cys Leu Pro Gly Leu Gly Pro Cys Gly 
    370                 375                 380                 


Ser Leu Lys Ala Pro Ser Pro Arg Ser Ser Ala Ser His Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Gln Ser Arg Cys Ser Ile Ser Lys Ile Ser Glu His Val Val 
                405                 410                 415     


Leu Thr Ser Val Thr Thr Val Leu Pro 
            420                 425 


<210>  99
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Asp Arg Val Leu Leu Arg Trp Ile Ser Leu Phe Trp Leu Thr Ala 
1               5                   10                  15      


Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys Lys Lys Val Ala 
            20                  25                  30          


Met Leu Phe Gln Pro Thr Val Leu Arg Cys His Phe Ser Thr Ser Ser 
        35                  40                  45              


His Gln Pro Ala Val Val Gln Trp Lys Phe Lys Ser Tyr Cys Gln Asp 
    50                  55                  60                  


Arg Met Gly Glu Ser Leu Gly Met Ser Ser Thr Arg Ala Gln Ser Leu 
65                  70                  75                  80  


Ser Lys Arg Asn Leu Glu Trp Asp Pro Tyr Leu Asp Cys Leu Asp Ser 
                85                  90                  95      


Arg Arg Thr Val Arg Val Val Ala Ser Lys Gln Gly Ser Thr Val Thr 
            100                 105                 110         


Leu Gly Asp Phe Tyr Arg Gly Arg Glu Ile Thr Ile Val His Asp Ala 
        115                 120                 125             


Asp Leu Gln Ile Gly Lys Leu Met Trp Gly Asp Ser Gly Leu Tyr Tyr 
    130                 135                 140                 


Cys Ile Ile Thr Thr Pro Asp Asp Leu Glu Gly Lys Asn Glu Asp Ser 
145                 150                 155                 160 


Val Glu Leu Leu Val Leu Gly Arg Thr Gly Leu Leu Ala Asp Leu Leu 
                165                 170                 175     


Pro Ser Phe Ala Val Glu Ile Met Pro Glu Trp Val Phe Val Gly Leu 
            180                 185                 190         


Val Leu Leu Gly Val Phe Leu Phe Phe Val Leu Val Gly Ile Cys Trp 
        195                 200                 205             


Cys Gln Cys Cys Pro His Ser Cys Cys Cys Tyr Val Arg Cys Pro Cys 
    210                 215                 220                 


Cys Pro Asp Ser Cys Cys Cys Pro Gln Ala Leu Tyr Glu Ala Gly Lys 
225                 230                 235                 240 


Ala Ala Lys Ala Gly Tyr Pro Pro Ser Val Ser Gly Val Pro Gly Pro 
                245                 250                 255     


Tyr Ser Ile Pro Ser Val Pro Leu Gly Gly Ala Pro Ser Ser Gly Met 
            260                 265                 270         


Leu Met Asp Lys Pro His Pro Pro Pro Leu Ala Pro Ser Asp Ser Thr 
        275                 280                 285             


Gly Gly Ser His Ser Val Arg Lys Gly Tyr Arg Ile Gln Ala Asp Lys 
    290                 295                 300                 


Glu Arg Asp Ser Met Lys Val Leu Tyr Tyr Val Glu Lys Glu Leu Ala 
305                 310                 315                 320 


Gln Phe Asp Pro Ala Arg Arg Met Arg Gly Arg Tyr Asn Asn Thr Ile 
                325                 330                 335     


Ser Glu Leu Ser Ser Leu His Glu Glu Asp Ser Asn Phe Arg Gln Ser 
            340                 345                 350         


Phe His Gln Met Arg Ser Lys Gln Phe Pro Val Ser Gly Asp Leu Glu 
        355                 360                 365             


Ser Asn Pro Asp Tyr Trp Ser Gly Val Met Gly Gly Ser Ser Gly Ala 
    370                 375                 380                 


Ser Arg Gly Pro Ser Ala Met Glu Tyr Asn Lys Glu Asp Arg Glu Ser 
385                 390                 395                 400 


Phe Arg His Ser Gln Pro Arg Ser Lys Ser Glu Met Leu Ser Arg Lys 
                405                 410                 415     


Asn Phe Ala Thr Gly Val Pro Ala Val Ser Met Asp Glu Leu Ala Ala 
            420                 425                 430         


Phe Ala Asp Ser Tyr Gly Gln Arg Pro Arg Arg Ala Asp Gly Asn Ser 
        435                 440                 445             


His Glu Ala Arg Gly Gly Ser Arg Phe Glu Arg Ser Glu Ser Arg Ala 
    450                 455                 460                 


His Ser Gly Phe Tyr Gln Asp Asp Ser Leu Glu Glu Tyr Tyr Gly Gln 
465                 470                 475                 480 


Arg Ser Arg Ser Arg Glu Pro Leu Thr Asp Ala Asp Arg Gly Trp Ala 
                485                 490                 495     


Phe Ser Pro Ala Arg Arg Arg Pro Ala Glu Asp Ala His Leu Pro Arg 
            500                 505                 510         


Leu Val Ser Arg Thr Pro Gly Thr Ala Pro Lys Tyr Asp His Ser Tyr 
        515                 520                 525             


Leu Gly Ser Ala Arg Glu Arg Gln Ala Arg Pro Glu Gly Ala Ser Arg 
    530                 535                 540                 


Gly Gly Ser Leu Glu Thr Pro Ser Lys Arg Ser Ala Gln Leu Gly Pro 
545                 550                 555                 560 


Arg Ser Ala Ser Tyr Tyr Ala Trp Ser Pro Pro Gly Thr Tyr Lys Ala 
                565                 570                 575     


Gly Ser Ser Gln Asp Asp Gln Glu Asp Ala Ser Asp Asp Ala Leu Pro 
            580                 585                 590         


Pro Tyr Ser Glu Leu Glu Leu Thr Arg Gly Pro Ser Tyr Arg Gly Arg 
        595                 600                 605             


Asp Leu Pro Tyr His Ser Asn Ser Glu Lys Lys Arg Lys Lys Glu Pro 
    610                 615                 620                 


Ala Lys Lys Thr Asn Asp Phe Pro Thr Arg Met Ser Leu Val Val 
625                 630                 635                 


<210>  100
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asn Asn Phe Ile Leu Leu Glu Glu Gln Leu Ile Lys Lys Ser Gln 
1               5                   10                  15      


Gln Lys Arg Arg Thr Ser Pro Ser Asn Phe Lys Val Arg Phe Phe Val 
            20                  25                  30          


Leu Thr Lys Ala Ser Leu Ala Tyr Phe Glu Asp Arg His Gly Lys Lys 
        35                  40                  45              


Arg Thr Leu Lys Gly Ser Ile Glu Leu Ser Arg Ile Lys Cys Val Glu 
    50                  55                  60                  


Ile Val Lys Ser Asp Ile Ser Ile Pro Cys His Tyr Lys Tyr Pro Phe 
65                  70                  75                  80  


Gln Val Val His Asp Asn Tyr Leu Leu Tyr Val Phe Ala Pro Asp Arg 
                85                  90                  95      


Glu Ser Arg Gln Arg Trp Val Leu Ala Leu Lys Glu Glu Thr Arg Asn 
            100                 105                 110         


Asn Asn Ser Leu Val Pro Lys Tyr His Pro Asn Phe Trp Met Asp Gly 
        115                 120                 125             


Lys Trp Arg Cys Cys Ser Gln Leu Glu Lys Leu Ala Thr Gly Cys Ala 
    130                 135                 140                 


Gln Tyr Asp Pro Thr Lys Asn Ala Ser Lys Lys Pro Leu Pro Pro Thr 
145                 150                 155                 160 


Pro Glu Asp Asn Arg Arg Pro Leu Trp Glu Pro Glu Glu Thr Val Val 
                165                 170                 175     


Ile Ala Leu Tyr Asp Tyr Gln Thr Asn Asp Pro Gln Glu Leu Ala Leu 
            180                 185                 190         


Arg Arg Asn Glu Glu Tyr Cys Leu Leu Asp Ser Ser Glu Ile His Trp 
        195                 200                 205             


Trp Arg Val Gln Asp Arg Asn Gly His Glu Gly Tyr Val Pro Ser Ser 
    210                 215                 220                 


Tyr Leu Val Glu Lys Ser Pro Asn Asn Leu Glu Thr Tyr Glu Trp Tyr 
225                 230                 235                 240 


Asn Lys Ser Ile Ser Arg Asp Lys Ala Glu Lys Leu Leu Leu Asp Thr 
                245                 250                 255     


Gly Lys Glu Gly Ala Phe Met Val Arg Asp Ser Arg Thr Ala Gly Thr 
            260                 265                 270         


Tyr Thr Val Ser Val Phe Thr Lys Ala Val Val Ser Glu Asn Asn Pro 
        275                 280                 285             


Cys Ile Lys His Tyr His Ile Lys Glu Thr Asn Asp Asn Pro Lys Arg 
    290                 295                 300                 


Tyr Tyr Val Ala Glu Lys Tyr Val Phe Asp Ser Ile Pro Leu Leu Ile 
305                 310                 315                 320 


Asn Tyr His Gln His Asn Gly Gly Gly Leu Val Thr Arg Leu Arg Tyr 
                325                 330                 335     


Pro Val Cys Phe Gly Arg Gln Lys Ala Pro Val Thr Ala Gly Leu Arg 
            340                 345                 350         


Tyr Gly Lys Trp Val Ile Asp Pro Ser Glu Leu Thr Phe Val Gln Glu 
        355                 360                 365             


Ile Gly Ser Gly Gln Phe Gly Leu Val His Leu Gly Tyr Trp Leu Asn 
    370                 375                 380                 


Lys Asp Lys Val Ala Ile Lys Thr Ile Arg Glu Gly Ala Met Ser Glu 
385                 390                 395                 400 


Glu Asp Phe Ile Glu Glu Ala Glu Val Met Met Lys Leu Ser His Pro 
                405                 410                 415     


Lys Leu Val Gln Leu Tyr Gly Val Cys Leu Glu Gln Ala Pro Ile Cys 
            420                 425                 430         


Leu Val Phe Glu Phe Met Glu His Gly Cys Leu Ser Asp Tyr Leu Arg 
        435                 440                 445             


Thr Gln Arg Gly Leu Phe Ala Ala Glu Thr Leu Leu Gly Met Cys Leu 
    450                 455                 460                 


Asp Val Cys Glu Gly Met Ala Tyr Leu Glu Glu Ala Cys Val Ile His 
465                 470                 475                 480 


Arg Asp Leu Ala Ala Arg Asn Cys Leu Val Gly Glu Asn Gln Val Ile 
                485                 490                 495     


Lys Val Ser Asp Phe Gly Met Thr Arg Phe Val Leu Asp Asp Gln Tyr 
            500                 505                 510         


Thr Ser Ser Thr Gly Thr Lys Phe Pro Val Lys Trp Ala Ser Pro Glu 
        515                 520                 525             


Val Phe Ser Phe Ser Arg Tyr Ser Ser Lys Ser Asp Val Trp Ser Phe 
    530                 535                 540                 


Gly Val Leu Met Trp Glu Val Phe Ser Glu Gly Lys Ile Pro Tyr Glu 
545                 550                 555                 560 


Asn Arg Ser Asn Ser Glu Val Val Glu Asp Ile Ser Thr Gly Phe Arg 
                565                 570                 575     


Leu Tyr Lys Pro Arg Leu Ala Ser Thr His Val Tyr Gln Ile Met Asn 
            580                 585                 590         


His Cys Trp Lys Glu Arg Pro Glu Asp Arg Pro Ala Phe Ser Arg Leu 
        595                 600                 605             


Leu Arg Gln Leu Ala Glu Ile Ala Glu Ser Gly Leu 
    610                 615                 620 


<210>  101
<211>  665
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu Ser Gly Gly Arg Arg Met Thr Lys Val Val Arg 
        435                 440                 445             


Asp Phe Leu Lys Ala Gln Gln Val Gln Ala Pro Val Glu Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Thr Val Gly His Val Asp Glu Phe Met Ser Phe Val Pro 
465                 470                 475                 480 


Ile Pro Gly Thr Lys Lys Phe Leu Leu Leu Met Ala Ser Thr Ser Ala 
                485                 490                 495     


Cys Tyr Lys Leu Phe Arg Glu Lys Gln Lys Asp Gly His Gly Glu Ala 
            500                 505                 510         


Ile Met Phe Lys Gly Leu Gly Gly Met Ser Ser Lys Arg Ile Thr Ile 
        515                 520                 525             


Asn Lys Ile Leu Ser Asn Glu Ser Leu Val Gln Glu Asn Leu Tyr Phe 
    530                 535                 540                 


Gln Arg Cys Leu Asp Trp Asn Arg Asp Ile Leu Lys Lys Glu Leu Gly 
545                 550                 555                 560 


Leu Thr Glu Gln Asp Ile Ile Asp Leu Pro Ala Leu Phe Lys Met Asp 
                565                 570                 575     


Glu Asp His Arg Ala Arg Ala Phe Phe Pro Asn Met Val Asn Met Ile 
            580                 585                 590         


Val Leu Asp Lys Asp Leu Gly Ile Pro Lys Pro Phe Gly Pro Gln Val 
        595                 600                 605             


Glu Glu Glu Cys Cys Leu Glu Met His Val Arg Gly Leu Leu Glu Pro 
    610                 615                 620                 


Leu Gly Leu Glu Cys Thr Phe Ile Asp Asp Ile Ser Ala Tyr His Lys 
625                 630                 635                 640 


Phe Leu Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe 
                645                 650                 655     


Thr Phe Lys Trp Trp His Met Val Pro 
            660                 665 


<210>  102
<211>  437
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Leu Arg Glu Arg Thr Val Arg Leu Gln Tyr Gly Ser Arg Val Glu 
1               5                   10                  15      


Ala Val Tyr Val Leu Gly Thr Tyr Leu Trp Thr Asp Val Tyr Ser Ala 
            20                  25                  30          


Ala Pro Ala Gly Ala Gln Thr Phe Ser Leu Lys His Ser Glu His Val 
        35                  40                  45              


Trp Val Glu Val Val Arg Asp Gly Glu Ala Glu Glu Val Ala Thr Asn 
    50                  55                  60                  


Gly Lys Gln Arg Trp Leu Leu Ser Pro Ser Thr Thr Leu Arg Val Thr 
65                  70                  75                  80  


Met Ser Gln Ala Ser Thr Glu Ala Ser Ser Asp Lys Val Thr Val Asn 
                85                  90                  95      


Tyr Tyr Asp Glu Glu Gly Ser Ile Pro Ile Asp Gln Ala Gly Leu Phe 
            100                 105                 110         


Leu Thr Ala Ile Glu Ile Ser Leu Asp Val Asp Ala Asp Arg Asp Gly 
        115                 120                 125             


Val Val Glu Lys Asn Asn Pro Lys Lys Ala Ser Trp Thr Trp Gly Pro 
    130                 135                 140                 


Glu Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Glu Thr Pro 
145                 150                 155                 160 


Trp Leu Pro Lys Glu Asp Cys Arg Asp Glu Lys Val Tyr Ser Lys Glu 
                165                 170                 175     


Asp Leu Lys Asp Met Ser Gln Met Ile Leu Arg Thr Lys Gly Pro Asp 
            180                 185                 190         


Arg Leu Pro Ala Gly Tyr Glu Ile Val Leu Tyr Ile Ser Met Ser Asp 
        195                 200                 205             


Ser Asp Lys Val Gly Val Phe Tyr Val Glu Asn Pro Phe Phe Gly Gln 
    210                 215                 220                 


Arg Tyr Ile His Ile Leu Gly Arg Arg Lys Leu Tyr His Val Val Lys 
225                 230                 235                 240 


Tyr Thr Gly Gly Ser Ala Glu Leu Leu Phe Phe Val Glu Gly Leu Cys 
                245                 250                 255     


Phe Pro Asp Glu Gly Phe Ser Gly Leu Val Ser Ile His Val Ser Leu 
            260                 265                 270         


Leu Glu Tyr Met Ala Gln Asp Ile Pro Leu Thr Pro Ile Phe Thr Asp 
        275                 280                 285             


Thr Val Ile Phe Arg Ile Ala Pro Trp Ile Met Thr Pro Asn Ile Leu 
    290                 295                 300                 


Pro Pro Val Ser Val Phe Val Cys Cys Met Lys Asp Asn Tyr Leu Phe 
305                 310                 315                 320 


Leu Lys Glu Val Lys Asn Leu Val Glu Lys Thr Asn Cys Glu Leu Lys 
                325                 330                 335     


Val Cys Phe Gln Tyr Leu Asn Arg Gly Asp Arg Trp Ile Gln Asp Glu 
            340                 345                 350         


Ile Glu Phe Gly Tyr Ile Glu Ala Pro His Lys Gly Phe Pro Val Val 
        355                 360                 365             


Leu Asp Ser Pro Arg Asp Gly Asn Leu Lys Asp Phe Pro Val Lys Glu 
    370                 375                 380                 


Leu Leu Gly Pro Asp Phe Gly Tyr Val Thr Arg Glu Pro Leu Phe Glu 
385                 390                 395                 400 


Ser Val Thr Ser Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro 
                405                 410                 415     


Val Thr Val Asn Gly Lys Thr Tyr Pro Leu Gly Arg Ile Leu Ile Gly 
            420                 425                 430         


Ser Ser Phe Pro Leu 
        435         


<210>  103
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Glu Ala Glu Gly Ser Ser Ala Pro Ala Arg Ala Gly Ser Gly Glu 
1               5                   10                  15      


Gly Ser Asp Ser Ala Gly Gly Ala Thr Leu Lys Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg His Glu Gln His His Gln Tyr Pro Leu Arg Gln Pro Gln Phe 
        35                  40                  45              


Arg Leu Leu His Pro His His His Leu Pro Pro Pro Pro Pro Pro Ser 
    50                  55                  60                  


Pro Gln Pro Gln Pro Gln Cys Pro Leu Gln Pro Pro Pro Pro Pro Pro 
65                  70                  75                  80  


Leu Pro Pro Pro Pro Pro Pro Pro Gly Ala Ala Arg Gly Arg Tyr Ala 
                85                  90                  95      


Ser Ser Gly Ala Thr Gly Arg Val Arg His Arg Gly Tyr Ser Asp Thr 
            100                 105                 110         


Glu Arg Tyr Leu Tyr Cys Arg Ala Met Asp Arg Thr Ser Tyr Ala Val 
        115                 120                 125             


Glu Thr Gly His Arg Pro Gly Leu Lys Lys Ser Arg Met Ser Trp Pro 
    130                 135                 140                 


Ser Ser Phe Gln Gly Leu Arg Arg Phe Asp Val Asp Asn Gly Thr Ser 
145                 150                 155                 160 


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
                165                 170                 175     


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
            180                 185                 190         


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
        195                 200                 205             


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
    210                 215                 220                 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
225                 230                 235                 240 


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
                245                 250                 255     


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
            260                 265                 270         


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
        275                 280                 285             


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
    290                 295                 300                 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
305                 310                 315                 320 


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
                325                 330                 335     


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
            340                 345                 350         


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
        355                 360                 365             


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
    370                 375                 380                 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
385                 390                 395                 400 


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
                405                 410                 415     


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
            420                 425                 430         


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
        435                 440                 445             


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
    450                 455                 460                 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
465                 470                 475                 480 


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
                485                 490                 495     


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
            500                 505                 510         


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
        515                 520                 525             


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
    530                 535                 540                 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
545                 550                 555                 560 


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
                565                 570                 575     


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
            580                 585                 590         


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
        595                 600                 605             


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
    610                 615                 620                 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
625                 630                 635                 640 


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
                645                 650                 655     


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
            660                 665                 670         


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
        675                 680                 685             


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
    690                 695                 700                 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
705                 710                 715                 720 


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
                725                 730                 735     


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
            740                 745                 750         


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
        755                 760                 765             


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
    770                 775                 780                 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
785                 790                 795                 800 


Val Ile Asp Asp Arg Ser Pro Asp Thr 
                805                 


<210>  104
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Met His Val Asn Asn Phe Pro Phe Arg Arg His Ser Trp Ile Cys 
1               5                   10                  15      


Phe Asp Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro 
            20                  25                  30          


Met Thr Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His 
        35                  40                  45              


Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp 
    50                  55                  60                  


Leu Ser Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile 
65                  70                  75                  80  


His Gly Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser 
                85                  90                  95      


Leu Arg Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp 
            100                 105                 110         


Arg Ala Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn 
        115                 120                 125             


Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr 
    130                 135                 140                 


Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr 
145                 150                 155                 160 


Arg His Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu 
                165                 170                 175     


Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln 
            180                 185                 190         


Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val 
        195                 200                 205             


Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro 
    210                 215                 220                 


Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu 
225                 230                 235                 240 


Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp 
                245                 250                 255     


Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val 
            260                 265                 270         


Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met 
        275                 280                 285             


His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro 
    290                 295                 300                 


Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His 
305                 310                 315                 320 


Ala Asp Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln 
                325                 330                 335     


Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr 
            340                 345                 350         


Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val 
        355                 360                 365             


Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu 
    370                 375                 380                 


Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu 
385                 390                 395                 400 


Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln 
                405                 410                 415     


Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp 
            420                 425                 430         


Ile Val Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp 
        435                 440                 445             


Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu 
    450                 455                 460                 


Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val 
465                 470                 475                 480 


His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg 
                485                 490                 495     


Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg 
            500                 505                 510         


Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn 
        515                 520                 525             


Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His 
    530                 535                 540                 


Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp 
545                 550                 555                 560 


Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile 
                565                 570                 575     


Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln 
            580                 585                 590         


Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly 
        595                 600                 605             


Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr 
    610                 615                 620                 


Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr 
625                 630                 635                 640 


Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu 
                645                 650                 655     


Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp 
            660                 665                 670         


Thr 
    


<210>  105
<211>  604
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
1               5                   10                  15      


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
            20                  25                  30          


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
        35                  40                  45              


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
    50                  55                  60                  


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
65                  70                  75                  80  


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
                85                  90                  95      


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
            100                 105                 110         


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
        115                 120                 125             


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
    130                 135                 140                 


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
145                 150                 155                 160 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
                165                 170                 175     


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
            180                 185                 190         


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
        195                 200                 205             


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
    210                 215                 220                 


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
225                 230                 235                 240 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
                245                 250                 255     


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
            260                 265                 270         


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
        275                 280                 285             


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
    290                 295                 300                 


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
305                 310                 315                 320 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
                325                 330                 335     


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
            340                 345                 350         


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
        355                 360                 365             


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
    370                 375                 380                 


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
385                 390                 395                 400 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
                405                 410                 415     


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
            420                 425                 430         


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
        435                 440                 445             


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
    450                 455                 460                 


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
465                 470                 475                 480 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
                485                 490                 495     


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
            500                 505                 510         


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
        515                 520                 525             


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
    530                 535                 540                 


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
545                 550                 555                 560 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
                565                 570                 575     


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
            580                 585                 590         


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        595                 600                 


<210>  106
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Lys Glu Gln Pro Ser Cys Ala Gly Thr Gly His Pro Met Ala Gly 
1               5                   10                  15      


Tyr Gly Arg Met Ala Pro Phe Glu Leu Ala Ser Gly Pro Val Lys Arg 
            20                  25                  30          


Leu Arg Thr Glu Ser Pro Phe Pro Cys Leu Phe Ala Glu Glu Ala Tyr 
        35                  40                  45              


Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp 
    50                  55                  60                  


Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser 
65                  70                  75                  80  


Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu 
                85                  90                  95      


Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe 
            100                 105                 110         


Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu 
        115                 120                 125             


Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys 
    130                 135                 140                 


Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly 
145                 150                 155                 160 


Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val 
                165                 170                 175     


Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn 
            180                 185                 190         


Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu 
        195                 200                 205             


Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met 
    210                 215                 220                 


Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile 
225                 230                 235                 240 


His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro 
                245                 250                 255     


Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe 
            260                 265                 270         


Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe 
        275                 280                 285             


Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser 
    290                 295                 300                 


Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu 
305                 310                 315                 320 


Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser 
                325                 330                 335     


Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys 
            340                 345                 350         


His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys 
        355                 360                 365             


Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile 
    370                 375                 380                 


Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr 
385                 390                 395                 400 


Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu 
                405                 410                 415     


Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser 
            420                 425                 430         


Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly 
        435                 440                 445             


Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu 
    450                 455                 460                 


Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg 
465                 470                 475                 480 


Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp 
                485                 490                 495     


Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu 
            500                 505                 510         


Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly 
        515                 520                 525             


Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys 
    530                 535                 540                 


Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu 
545                 550                 555                 560 


Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val 
                565                 570                 575     


Ile Asp Asp Arg Ser Pro Asp Thr 
            580                 


<210>  107
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His 
1               5                   10                  15      


Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser 
            20                  25                  30          


Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr 
        35                  40                  45              


Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly 
    50                  55                  60                  


Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro 
65                  70                  75                  80  


Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu 
                85                  90                  95      


Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu 
            100                 105                 110         


Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu 
        115                 120                 125             


Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr 
    130                 135                 140                 


Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His 
145                 150                 155                 160 


Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu 
                165                 170                 175     


Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala 
            180                 185                 190         


Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser 
        195                 200                 205             


Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn 
    210                 215                 220                 


Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu 
225                 230                 235                 240 


Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln 
                245                 250                 255     


Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp 
            260                 265                 270         


Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu 
        275                 280                 285             


Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser 
    290                 295                 300                 


Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser 
305                 310                 315                 320 


Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile 
                325                 330                 335     


Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met 
            340                 345                 350         


Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser 
        355                 360                 365             


Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp 
    370                 375                 380                 


Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu 
385                 390                 395                 400 


Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro 
                405                 410                 415     


Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe 
            420                 425                 430         


Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys 
        435                 440                 445             


Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys 
    450                 455                 460                 


Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu 
465                 470                 475                 480 


Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu 
                485                 490                 495     


Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            500                 505         


<210>  108
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
        195                 200                 205             


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    210                 215                 220                 


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
225                 230                 235                 240 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                245                 250                 255     


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            260                 265                 270         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        275                 280                 285             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    290                 295                 300                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
305                 310                 315                 320 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                325                 330                 335     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            340                 345                 350         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        355                 360                 365             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    370                 375                 380                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
385                 390                 395                 400 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                405                 410                 415     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            420                 425                 430         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        435                 440                 445             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    450                 455                 460                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
465                 470                 475                 480 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                485                 490                 495     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            500                 505                 510         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        515                 520                 525             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    530                 535                 540                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
545                 550                 555                 560 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                565                 570                 575     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            580                 585                 590         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        595                 600                 605             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    610                 615                 620                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
625                 630                 635                 640 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                645                 650                 655     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            660                 665                 670         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        675                 680                 685             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    690                 695                 700                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
705                 710                 715                 720 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                725                 730                 735     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745 


<210>  109
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Gly Leu Tyr 
        195                 200                 205             


Asn Gly Ile Ile Ala Phe Leu 
    210                 215 


<210>  110
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Pro Glu Ala Asn Tyr Leu Leu Ser Val Ser Trp Gly Tyr Ile Lys 
1               5                   10                  15      


Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met Ser 
            20                  25                  30          


Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu Asp 
        35                  40                  45              


Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys Glu 
    50                  55                  60                  


Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu Met 
65                  70                  75                  80  


His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val Lys 
                85                  90                  95      


Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn Lys 
            100                 105                 110         


Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg Pro 
        115                 120                 125             


Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu Lys 
    130                 135                 140                 


Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr Leu 
145                 150                 155                 160 


Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His Ala 
                165                 170                 175     


Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala Leu 
            180                 185                 190         


Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala Ser 
        195                 200                 205             


Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu Ile 
    210                 215                 220                 


Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val Leu 
225                 230                 235                 240 


Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu Asn 
                245                 250                 255     


Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu Arg 
            260                 265                 270         


Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His Met 
        275                 280                 285             


Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val Thr 
    290                 295                 300                 


Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln Val 
305                 310                 315                 320 


Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys Pro 
                325                 330                 335     


Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe Phe 
            340                 345                 350         


Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro Met 
        355                 360                 365             


Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe Ile 
    370                 375                 380                 


Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val His 
385                 390                 395                 400 


Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu Trp 
                405                 410                 415     


Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp Pro 
            420                 425                 430         


Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu Thr 
        435                 440                 445             


Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser Gln 
    450                 455                 460                 


Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr Gln 
465                 470                 475                 480 


Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu Glu 
                485                 490                 495     


Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile Asp 
            500                 505                 510         


Asp Arg Ser Pro Asp Thr 
        515             


<210>  111
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Ala Phe Val Trp Asp Pro Leu Gly Ala Thr Val Pro Gly Pro Ser 
1               5                   10                  15      


Thr Arg Ala Lys Ser Arg Leu Arg Phe Ser Lys Ser Tyr Ser Phe Asp 
            20                  25                  30          


Val Asp Asn Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr 
        35                  40                  45              


Ser Pro Gly Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln 
    50                  55                  60                  


Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser 
65                  70                  75                  80  


Pro Lys Ser Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly 
                85                  90                  95      


Asp Asp Leu Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg 
            100                 105                 110         


Thr Val Arg Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala 
        115                 120                 125             


Pro Ser Lys Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala 
    130                 135                 140                 


Thr Ile Thr Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu 
145                 150                 155                 160 


Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His 
                165                 170                 175     


Ser Val Ser Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg 
            180                 185                 190         


Glu Leu Thr His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser 
        195                 200                 205             


Glu Phe Ile Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile 
    210                 215                 220                 


Pro Ser Pro Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser 
225                 230                 235                 240 


Gln Ile Ser Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn 
                245                 250                 255     


Ser Ser Ile Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu 
            260                 265                 270         


Ala Lys Glu Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg 
        275                 280                 285             


Ile Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr 
    290                 295                 300                 


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp 
305                 310                 315                 320 


Thr Leu Ile Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp 
                325                 330                 335     


Val Ala Tyr His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr 
            340                 345                 350         


His Val Leu Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
        355                 360                 365             


Glu Ile Leu Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His 
    370                 375                 380                 


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
385                 390                 395                 400 


Leu Met Tyr Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val 
                405                 410                 415     


Gly Phe Lys Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu 
            420                 425                 430         


Thr Lys Lys Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val 
        435                 440                 445             


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
    450                 455                 460                 


Thr Met Val Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu 
465                 470                 475                 480 


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys 
                485                 490                 495     


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp 
            500                 505                 510         


Thr Asp Arg Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg 
        515                 520                 525             


Glu Arg Gly Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser 
    530                 535                 540                 


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu 
545                 550                 555                 560 


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu 
                565                 570                 575     


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln 
            580                 585                 590         


Ser Pro Ser Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln 
        595                 600                 605             


Thr Glu Lys Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser 
    610                 615                 620                 


Asp Thr Glu Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys 
625                 630                 635                 640 


Ser Asp Ser Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile 
                645                 650                 655     


Pro Leu Asp Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu 
            660                 665                 670         


Ser Gln Pro Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
        675                 680                 685         


<210>  112
<211>  679
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Ser Ile Ile Met Lys Pro Arg Ser Arg Ser Thr Ser Ser Leu Arg 
1               5                   10                  15      


Thr Ala Glu Ala Val Cys Phe Asp Val Asp Asn Gly Thr Ser Ala Gly 
            20                  25                  30          


Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu Ile Leu 
        35                  40                  45              


Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg 
    50                  55                  60                  


Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg Asn Ser 
65                  70                  75                  80  


Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr Pro Phe 
                85                  90                  95      


Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe Ala Ala 
            100                 105                 110         


Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro Met Cys 
        115                 120                 125             


Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala Tyr Gln 
    130                 135                 140                 


Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu Asp Gln 
145                 150                 155                 160 


Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala Ser Asn 
                165                 170                 175     


Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser Glu Met 
            180                 185                 190         


Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr Phe Leu 
        195                 200                 205             


Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys Glu Lys 
    210                 215                 220                 


Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys Lys Leu 
225                 230                 235                 240 


Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe Gly Val 
                245                 250                 255     


Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp Val Asn 
            260                 265                 270         


Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly Asn Arg 
        275                 280                 285             


Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp Leu Leu 
    290                 295                 300                 


Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu Met Thr 
305                 310                 315                 320 


Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn Ile His 
                325                 330                 335     


Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr Pro Ala 
            340                 345                 350         


Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile Phe Ala 
        355                 360                 365             


Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln Phe Leu 
    370                 375                 380                 


Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser Ser Val 
385                 390                 395                 400 


Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln Glu Glu 
                405                 410                 415     


Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln Ser Leu 
            420                 425                 430         


Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser Lys His 
        435                 440                 445             


Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys Lys Val 
    450                 455                 460                 


Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg Ile Gln 
465                 470                 475                 480 


Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro Thr Lys 
                485                 490                 495     


Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu Glu Phe 
            500                 505                 510         


Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile Ser Pro 
        515                 520                 525             


Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val Gly Phe 
    530                 535                 540                 


Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp Leu Val 
545                 550                 555                 560 


His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn Arg Glu 
                565                 570                 575     


Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro Asp Asp 
            580                 585                 590         


Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe Glu Leu 
        595                 600                 605             


Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser Gly Ser 
    610                 615                 620                 


Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu Cys Thr 
625                 630                 635                 640 


Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val Glu Glu 
                645                 650                 655     


Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys Val Ile 
            660                 665                 670         


Asp Asp Arg Ser Pro Asp Thr 
        675                 


<210>  113
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Lys Arg Asn Thr Cys Asp Leu Leu Ser Arg Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Glu Thr Leu His Ser Ser Asn Glu Glu Glu Asp Pro Phe Arg Gly 
            20                  25                  30          


Met Glu Pro Tyr Leu Val Arg Arg Leu Ser Cys Arg Asn Ile Gln Leu 
        35                  40                  45              


Pro Pro Leu Ala Phe Arg Gln Leu Glu Gln Ala Asp Leu Lys Ser Glu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Arg Pro Thr Ser Leu Pro Leu Lys Ile Leu Pro 
65                  70                  75                  80  


Leu Ile Ala Ile Thr Ser Ala Glu Ser Ser Gly Phe Asp Val Asp Asn 
                85                  90                  95      


Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly 
            100                 105                 110         


Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu 
        115                 120                 125             


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser 
    130                 135                 140                 


Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
145                 150                 155                 160 


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
                165                 170                 175     


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
            180                 185                 190         


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
        195                 200                 205             


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
    210                 215                 220                 


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
225                 230                 235                 240 


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
                245                 250                 255     


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
            260                 265                 270         


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
        275                 280                 285             


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
    290                 295                 300                 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
305                 310                 315                 320 


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
                325                 330                 335     


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
            340                 345                 350         


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
        355                 360                 365             


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
385                 390                 395                 400 


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
                405                 410                 415     


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
            420                 425                 430         


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
        435                 440                 445             


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
    450                 455                 460                 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
465                 470                 475                 480 


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
                485                 490                 495     


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
            500                 505                 510         


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
        515                 520                 525             


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
    530                 535                 540                 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
545                 550                 555                 560 


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
                565                 570                 575     


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
            580                 585                 590         


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
        595                 600                 605             


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
    610                 615                 620                 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
625                 630                 635                 640 


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
                645                 650                 655     


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
            660                 665                 670         


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
        675                 680                 685             


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
    690                 695                 700                 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
                725                 730                 735     


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745             


<210>  114
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Gly Ser Trp 
        195                 200                 205             


Met Glu Leu Asn Pro Tyr Thr Leu Leu Asp Met 
    210                 215                 


<210>  115
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Lys Val Leu Leu Cys Asp Leu Leu Leu Leu Ser Leu Phe Ser Ser 
1               5                   10                  15      


Val Phe Ser Ser Cys Gln Arg Asp Cys Leu Thr Cys Gln Glu Lys Leu 
            20                  25                  30          


His Pro Ala Leu Asp Ser Phe Asp Leu Glu Val Cys Ile Leu Glu Cys 
        35                  40                  45              


Glu Glu Lys Val Phe Pro Ser Pro Leu Trp Thr Pro Cys Thr Lys Val 
    50                  55                  60                  


Met Ala Arg Ser Ser Trp Gln Leu Ser Pro Ala Ala Pro Glu His Val 
65                  70                  75                  80  


Ala Ala Ala Leu Tyr Gln Pro Arg Ala Ser Glu Met Gln His Leu Arg 
                85                  90                  95      


Arg Met Pro Arg Val Arg Ser Leu Phe Gln Glu Gln Glu Glu Pro Glu 
            100                 105                 110         


Pro Gly Met Glu Glu Ala Gly Glu Met Glu Gln Lys Gln Leu Gln Lys 
        115                 120                 125             


Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala 
    130                 135                 140                 


Asn Gln Lys Arg Phe Ser Glu Phe Met Arg Gln Tyr Leu Val Leu Ser 
145                 150                 155                 160 


Met Gln Ser Ser Gln Arg Arg Arg Thr Leu His Gln Asn Gly Asn Val 
                165                 170                 175     


<210>  116
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Arg Ser Ser Trp Gln Leu Ser Pro Ala Ala Pro Glu His Val 
1               5                   10                  15      


Ala Ala Ala Leu Tyr Gln Pro Arg Ala Ser Glu Met Gln His Leu Arg 
            20                  25                  30          


Arg Met Pro Arg Val Arg Ser Leu Phe Gln Glu Gln Glu Glu Pro Glu 
        35                  40                  45              


Pro Gly Met Glu Glu Ala Gly Glu Met Glu Gln Lys Gln Leu Gln Lys 
    50                  55                  60                  


Arg Phe Gly Gly Phe Thr Gly Ala Arg Lys Ser Ala Arg Lys Leu Ala 
65                  70                  75                  80  


Asn Gln Lys Arg Phe Ser Glu Phe Met Arg Gln Tyr Leu Val Leu Ser 
                85                  90                  95      


Met Gln Ser Ser Gln Arg Arg Arg Thr Leu His Gln Asn Gly Asn Val 
            100                 105                 110         


<210>  117
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Thr Ile Arg His Gln Gly Gln Gln Tyr Arg Pro Arg Met Ala Phe 
1               5                   10                  15      


Leu Gln Lys Ile Glu Ala Leu Val Lys Asp Met Gln Asn Pro Glu Thr 
            20                  25                  30          


Gly Val Arg Met Gln Asn Gln Arg Val Leu Val Thr Ser Val Pro His 
        35                  40                  45              


Ala Met Thr Gly Ser Asp Val Leu Gln Trp Ile Val Gln Arg Leu Trp 
    50                  55                  60                  


Ile Ser Ser Leu Glu Ala Gln Asn Leu Gly Asn Phe Ile Val Arg Tyr 
65                  70                  75                  80  


Gly Tyr Ile Tyr Pro Leu Gln Asp Pro Lys Asn Leu Ile Leu Lys Pro 
                85                  90                  95      


Asp Gly Ser Leu Tyr Arg Phe Gln Thr Pro Tyr Phe Trp Pro Thr Gln 
            100                 105                 110         


Gln Trp Pro Ala Glu Asp Thr Asp Tyr Ala Ile Tyr Leu Ala Lys Arg 
        115                 120                 125             


Asn Ile Lys Lys Lys Gly Ile Leu Glu Glu Tyr Glu Lys Glu Asn Tyr 
    130                 135                 140                 


Asn Phe Leu Asn Gln Lys Met Asn Tyr Lys Trp Asp Phe Val Ile Met 
145                 150                 155                 160 


Gln Ala Lys Glu Gln Tyr Arg Ala Gly Lys Glu Arg Asn Lys Ala Asp 
                165                 170                 175     


Arg Tyr Ala Leu Asp Cys Gln Glu Lys Ala Tyr Trp Leu Val His Arg 
            180                 185                 190         


Cys Pro Pro Gly Met Asp Asn Val Leu Asp Tyr Gly Leu Asp Arg Val 
        195                 200                 205             


Thr Asn Pro Asn Glu Val Lys Val Asn Gln Lys Gln Thr Val Val Ala 
    210                 215                 220                 


Val Lys Lys Glu Ile Met Tyr Tyr Gln Gln Ala Leu Met Arg Ser Thr 
225                 230                 235                 240 


Val Lys Ser Ser Val Ser Leu Gly Gly Ile Val Lys Tyr Ser Glu Gln 
                245                 250                 255     


Phe Ser Ser Asn Asp Ala Ile Met Ser Gly Cys Leu Pro Ser Asn Pro 
            260                 265                 270         


Trp Ile Thr Asp Asp Thr Gln Phe Trp Asp Leu Asn Ala Lys Leu Val 
        275                 280                 285             


Glu Ile Pro Thr Lys Met Arg Val Glu Arg Trp Ala Phe Asn Phe Ser 
    290                 295                 300                 


Glu Leu Ile Arg Asp Pro Lys Gly Arg Gln Ser Phe Gln Tyr Phe Leu 
305                 310                 315                 320 


Lys Lys Glu Phe Ser Gly Glu Asn Leu Gly Phe Trp Glu Ala Cys Glu 
                325                 330                 335     


Asp Leu Lys Tyr Gly Asp Gln Ser Lys Val Lys Glu Lys Ala Glu Glu 
            340                 345                 350         


Ile Tyr Lys Leu Phe Leu Ala Pro Gly Ala Arg Arg Trp Ile Asn Ile 
        355                 360                 365             


Asp Gly Lys Thr Met Asp Ile Thr Val Lys Gly Leu Lys His Pro His 
    370                 375                 380                 


Arg Tyr Val Leu Asp Ala Ala Gln Thr His Ile Tyr Met Leu Met Lys 
385                 390                 395                 400 


Lys Asp Ser Tyr Ala Arg Tyr Leu Lys Ser Pro Ile Tyr Lys Asp Met 
                405                 410                 415     


Leu Ala Lys Ala Ile Glu Pro Gln Glu Thr Thr Lys Lys Ser Ser Thr 
            420                 425                 430         


Leu Pro Phe Met Arg Arg His Leu Arg Ser Ser Pro Ser Pro Val Ile 
        435                 440                 445             


Leu Arg Gln Leu Glu Glu Glu Ala Lys Ala Arg Glu Ala Ala Asn Thr 
    450                 455                 460                 


Val Asp Ile Thr Gln Pro Gly Gln His Met Ala Pro Ser Pro His Leu 
465                 470                 475                 480 


Thr Val Tyr Thr Gly Thr Cys Met Pro Pro Ser Pro Ser Ser Pro Phe 
                485                 490                 495     


Ser Ser Ser Cys Arg Ser Pro Arg Lys Pro Phe Ala Ser Pro Ser Arg 
            500                 505                 510         


Phe Ile Arg Arg Pro Ser Thr Thr Ile Cys Pro Ser Pro Ile Arg Val 
        515                 520                 525             


Ala Leu Glu Ser Ser Ser Gly Leu Glu Gln Lys Gly Glu Cys Ser Gly 
    530                 535                 540                 


Ser Met Ala Pro Arg Gly Pro Ser Val Thr Glu Ser Ser Glu Ala Ser 
545                 550                 555                 560 


Leu Asp Thr Ser Trp Pro Arg Ser Arg Pro Arg Ala Pro Pro Lys Ala 
                565                 570                 575     


Arg Met Ala Leu Ser Phe Ser Arg Phe Leu Arg Arg Gly Cys Leu Ala 
            580                 585                 590         


Ser Pro Val Phe Ala Arg Leu Ser Pro Lys Cys Pro Ala Val Ser His 
        595                 600                 605             


Gly Arg Val Gln Pro Leu Gly Asp Val Gly Gln Gln Leu Pro Arg Leu 
    610                 615                 620                 


Lys Ser Lys Arg Val Ala Asn Phe Phe Gln Ile Lys Met Asp Val Pro 
625                 630                 635                 640 


Thr Gly Ser Gly Thr Cys Leu Met Asp Ser Glu Asp Ala Gly Thr Gly 
                645                 650                 655     


Glu Ser Gly Asp Arg Ala Thr Glu Lys Glu Val Ile Cys Pro Trp Glu 
            660                 665                 670         


Ser Leu 
        


<210>  118
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Thr Ile Arg His Gln Gly Gln Gln Tyr Arg Pro Arg Met Ala Phe 
1               5                   10                  15      


Leu Gln Lys Ile Glu Ala Leu Val Lys Asp Met Gln Asn Pro Glu Thr 
            20                  25                  30          


Gly Val Arg Met Gln Asn Gln Arg Val Leu Val Thr Ser Val Pro His 
        35                  40                  45              


Ala Met Thr Gly Ser Asp Val Leu Gln Trp Ile Val Gln Arg Leu Trp 
    50                  55                  60                  


Ile Ser Ser Leu Glu Ala Gln Asn Leu Gly Asn Phe Ile Val Arg Tyr 
65                  70                  75                  80  


Gly Tyr Ile Tyr Pro Leu Gln Asp Pro Lys Asn Leu Ile Leu Lys Pro 
                85                  90                  95      


Asp Gly Ser Leu Tyr Arg Phe Gln Thr Pro Tyr Phe Trp Pro Thr Gln 
            100                 105                 110         


Gln Trp Pro Ala Glu Asp Thr Asp Tyr Ala Ile Tyr Leu Ala Lys Arg 
        115                 120                 125             


Asn Ile Lys Lys Lys Gly Ile Leu Glu Glu Tyr Glu Lys Glu Asn Tyr 
    130                 135                 140                 


Asn Phe Leu Asn Gln Lys Met Asn Tyr Lys Trp Asp Phe Val Ile Met 
145                 150                 155                 160 


Gln Ala Lys Glu Gln Tyr Arg Ala Gly Lys Glu Arg Asn Lys Ala Asp 
                165                 170                 175     


Arg Tyr Ala Leu Asp Cys Gln Glu Lys Ala Tyr Trp Leu Val His Arg 
            180                 185                 190         


Cys Pro Pro Gly Met Asp Asn Val Leu Asp Tyr Gly Leu Asp Arg Val 
        195                 200                 205             


Thr Asn Pro Asn Glu Val Lys Val Asn Gln Lys Gln Thr Val Val Ala 
    210                 215                 220                 


Val Lys Lys Glu Ile Met Tyr Tyr Gln Gln Ala Leu Met Arg Ser Thr 
225                 230                 235                 240 


Val Lys Ser Ser Val Ser Leu Gly Gly Ile Val Lys Tyr Ser Glu Gln 
                245                 250                 255     


Phe Ser Ser Asn Asp Ala Ile Met Ser Gly Cys Leu Pro Ser Asn Pro 
            260                 265                 270         


Trp Ile Thr Asp Asp Thr Gln Phe Trp Asp Leu Asn Ala Lys Leu Val 
        275                 280                 285             


Glu Ile Pro Thr Lys Met Arg Val Glu Arg Trp Ala Phe Asn Phe Ser 
    290                 295                 300                 


Glu Leu Ile Arg Asp Pro Lys Gly Arg Gln Ser Phe Gln Tyr Phe Leu 
305                 310                 315                 320 


Lys Lys Glu Phe Ser Gly Glu Asn Leu Gly Phe Trp Glu Ala Cys Glu 
                325                 330                 335     


Asp Leu Lys Tyr Gly Asp Gln Ser Lys Val Lys Glu Lys Ala Glu Glu 
            340                 345                 350         


Ile Tyr Lys Leu Phe Leu Ala Pro Gly Ala Arg Arg Trp Ile Asn Ile 
        355                 360                 365             


Asp Gly Lys Thr Met Asp Ile Thr Val Lys Gly Leu Lys His Pro His 
    370                 375                 380                 


Arg Tyr Val Leu Asp Ala Ala Gln Thr His Ile Tyr Met Leu Met Lys 
385                 390                 395                 400 


Lys Asp Ser Tyr Ala Arg Tyr Leu Lys Ser Pro Ile Tyr Lys Asp Met 
                405                 410                 415     


Leu Ala Lys Ala Ile Glu Pro Gln Glu Thr Thr Lys Lys Ser Ser Thr 
            420                 425                 430         


Leu Pro Phe Met Arg Arg His Leu Arg Ser Ser Pro Ser Pro Val Ile 
        435                 440                 445             


Leu Arg Gln Leu Glu Glu Glu Ala Lys Ala Arg Glu Ala Ala Asn Thr 
    450                 455                 460                 


Val Asp Ile Thr Gln 
465                 


<210>  119
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Thr Ile Arg His Gln Gly Gln Gln Tyr Arg Pro Arg Met Ala Phe 
1               5                   10                  15      


Leu Gln Lys Ile Glu Ala Leu Val Lys Asp Met Gln Asn Pro Glu Thr 
            20                  25                  30          


Gly Val Arg Met Gln Asn Gln Arg Val Leu Val Thr Ser Val Pro His 
        35                  40                  45              


Ala Met Thr Gly Ser Asp Val Leu Gln Trp Ile Val Gln Arg Leu Trp 
    50                  55                  60                  


Ile Ser Ser Leu Glu Ala Gln Asn Leu Gly Asn Phe Ile Val Arg Tyr 
65                  70                  75                  80  


Gly Tyr Ile Tyr Pro Leu Gln Asp Pro Lys Asn Leu Ile Leu Lys Pro 
                85                  90                  95      


Asp Gly Ser Leu Tyr Arg Phe Gln Thr Pro Tyr Phe Trp Pro Thr Gln 
            100                 105                 110         


Gln Trp Pro Ala Glu Asp Thr Asp Tyr Ala Ile Tyr Leu Ala Lys Arg 
        115                 120                 125             


Asn Ile Lys Lys Lys Gly Ile Leu Glu Glu Tyr Glu Lys Glu Asn Tyr 
    130                 135                 140                 


Asn Phe Leu Asn Gln Lys Met Asn Tyr Lys Trp Asp Phe Val Ile Met 
145                 150                 155                 160 


Gln Ala Lys Glu Gln Tyr Arg Ala Gly Lys Glu Arg Asn Lys Ala Asp 
                165                 170                 175     


Arg Tyr Ala Leu Asp Cys Gln Glu Lys Ala Tyr Trp Leu Val His Arg 
            180                 185                 190         


Cys Pro Pro Gly Met Asp Asn Val Leu Asp Tyr Gly Leu Asp Arg Val 
        195                 200                 205             


Thr Asn Pro Asn Glu Val Lys Lys Gln Thr Val Val Ala Val Lys Lys 
    210                 215                 220                 


Glu Ile Met Tyr Tyr Gln Gln Ala Leu Met Arg Ser Thr Val Lys Ser 
225                 230                 235                 240 


Ser Val Ser Leu Gly Gly Ile Val Lys Tyr Ser Glu Gln Phe Ser Ser 
                245                 250                 255     


Asn Asp Ala Ile Met Ser Gly Cys Leu Pro Ser Asn Pro Trp Ile Thr 
            260                 265                 270         


Asp Asp Thr Gln Phe Trp Asp Leu Asn Ala Lys Leu Val Glu Ile Pro 
        275                 280                 285             


Thr Lys Met Arg Val Glu Arg Trp Ala Phe Asn Phe Ser Glu Leu Ile 
    290                 295                 300                 


Arg Asp Pro Lys Gly Arg Gln Ser Phe Gln Tyr Phe Leu Lys Lys Glu 
305                 310                 315                 320 


Phe Ser Gly Glu Asn Leu Gly Phe Trp Glu Ala Cys Glu Asp Leu Lys 
                325                 330                 335     


Tyr Gly Asp Gln Ser Lys Val Lys Glu Lys Ala Glu Glu Ile Tyr Lys 
            340                 345                 350         


Leu Phe Leu Ala Pro Gly Ala Arg Arg Trp Ile Asn Ile Asp Gly Lys 
        355                 360                 365             


Thr Met Asp Ile Thr Val Lys Gly Leu Lys His Pro His Arg Tyr Val 
    370                 375                 380                 


Leu Asp Ala Ala Gln Thr His Ile Tyr Met Leu Met Lys Lys Asp Ser 
385                 390                 395                 400 


Tyr Ala Arg Tyr Leu Lys Ser Pro Ile Tyr Lys Asp Met Leu Ala Lys 
                405                 410                 415     


Ala Ile Glu Pro Gln Glu Thr Thr Lys Lys Ser Ser Thr Leu Pro Phe 
            420                 425                 430         


Met Arg Arg His Leu Arg Ser Ser Pro Ser Pro Val Ile Leu Arg Gln 
        435                 440                 445             


Leu Glu Glu Glu Ala Lys Ala Arg Glu Ala Ala Asn Thr Val Asp Ile 
    450                 455                 460                 


Thr Gln Val Met Ser Lys Leu Asp Arg Arg Ser Gln Leu Lys Lys Glu 
465                 470                 475                 480 


Leu Pro Pro Lys 
                


<210>  120
<211>  445
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Tyr Tyr Gln Gln Ala Leu Met Arg Ser Thr Val Lys Ser Ser Val 
1               5                   10                  15      


Ser Leu Gly Gly Ile Val Lys Tyr Ser Glu Gln Phe Ser Ser Asn Asp 
            20                  25                  30          


Ala Ile Met Ser Gly Cys Leu Pro Ser Asn Pro Trp Ile Thr Asp Asp 
        35                  40                  45              


Thr Gln Phe Trp Asp Leu Asn Ala Lys Leu Val Glu Ile Pro Thr Lys 
    50                  55                  60                  


Met Arg Val Glu Arg Trp Ala Phe Asn Phe Ser Glu Leu Ile Arg Asp 
65                  70                  75                  80  


Pro Lys Gly Arg Gln Ser Phe Gln Tyr Phe Leu Lys Lys Glu Phe Ser 
                85                  90                  95      


Gly Glu Asn Leu Gly Phe Trp Glu Ala Cys Glu Asp Leu Lys Tyr Gly 
            100                 105                 110         


Asp Gln Ser Lys Val Lys Glu Lys Ala Glu Glu Ile Tyr Lys Leu Phe 
        115                 120                 125             


Leu Ala Pro Gly Ala Arg Arg Trp Ile Asn Ile Asp Gly Lys Thr Met 
    130                 135                 140                 


Asp Ile Thr Val Lys Gly Leu Lys His Pro His Arg Tyr Val Leu Asp 
145                 150                 155                 160 


Ala Ala Gln Thr His Ile Tyr Met Leu Met Lys Lys Asp Ser Tyr Ala 
                165                 170                 175     


Arg Tyr Leu Lys Ser Pro Ile Tyr Lys Asp Met Leu Ala Lys Ala Ile 
            180                 185                 190         


Glu Pro Gln Glu Thr Thr Lys Lys Ser Ser Thr Leu Pro Phe Met Arg 
        195                 200                 205             


Arg His Leu Arg Ser Ser Pro Ser Pro Val Ile Leu Arg Gln Leu Glu 
    210                 215                 220                 


Glu Glu Ala Lys Ala Arg Glu Ala Ala Asn Thr Val Asp Ile Thr Gln 
225                 230                 235                 240 


Pro Gly Gln His Met Ala Pro Ser Pro His Leu Thr Val Tyr Thr Gly 
                245                 250                 255     


Thr Cys Met Pro Pro Ser Pro Ser Ser Pro Phe Ser Ser Ser Cys Arg 
            260                 265                 270         


Ser Pro Arg Lys Pro Phe Ala Ser Pro Ser Arg Phe Ile Arg Arg Pro 
        275                 280                 285             


Ser Thr Thr Ile Cys Pro Ser Pro Ile Arg Val Ala Leu Glu Ser Ser 
    290                 295                 300                 


Ser Gly Leu Glu Gln Lys Gly Glu Cys Ser Gly Ser Met Ala Pro Arg 
305                 310                 315                 320 


Gly Pro Ser Val Thr Glu Ser Ser Glu Ala Ser Leu Asp Thr Ser Trp 
                325                 330                 335     


Pro Arg Ser Arg Pro Arg Ala Pro Pro Lys Ala Arg Met Ala Leu Ser 
            340                 345                 350         


Phe Ser Arg Phe Leu Arg Arg Gly Cys Leu Ala Ser Pro Val Phe Ala 
        355                 360                 365             


Arg Leu Ser Pro Lys Cys Pro Ala Val Ser His Gly Arg Val Gln Pro 
    370                 375                 380                 


Leu Gly Asp Val Gly Gln Gln Leu Pro Arg Leu Lys Ser Lys Arg Val 
385                 390                 395                 400 


Ala Asn Phe Phe Gln Ile Lys Met Asp Val Pro Thr Gly Ser Gly Thr 
                405                 410                 415     


Cys Leu Met Asp Ser Glu Asp Ala Gly Thr Gly Glu Ser Gly Asp Arg 
            420                 425                 430         


Ala Thr Glu Lys Glu Val Ile Cys Pro Trp Glu Ser Leu 
        435                 440                 445 


<210>  121
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Thr Ile Arg His Gln Gly Gln Gln Tyr Arg Pro Arg Met Ala Phe 
1               5                   10                  15      


Leu Gln Lys Ile Glu Ala Leu Val Lys Asp Met Gln Asn Pro Glu Thr 
            20                  25                  30          


Gly Val Arg Met Gln Asn Gln Arg Val Leu Val Thr Ser Val Pro His 
        35                  40                  45              


Ala Met Thr Gly Ser Asp Val Leu Gln Trp Ile Val Gln Arg Leu Trp 
    50                  55                  60                  


Ile Ser Ser Leu Glu Ala Gln Asn Leu Gly Asn Phe Ile Val Arg Tyr 
65                  70                  75                  80  


Gly Tyr Ile Tyr Pro Leu Gln Asp Pro Lys Asn Leu Ile Leu Lys Pro 
                85                  90                  95      


Asp Gly Ser Leu Tyr Arg Phe Gln Thr Pro Tyr Phe Trp Pro Thr Gln 
            100                 105                 110         


Gln Trp Pro Ala Glu Asp Thr Asp Tyr Ala Ile Tyr Leu Ala Lys Arg 
        115                 120                 125             


Asn Ile Lys Lys Lys Gly Ile Leu Glu Glu Tyr Glu Lys Glu Asn Tyr 
    130                 135                 140                 


Asn Phe Leu Asn Gln Lys Met Asn Tyr Lys Trp Asp Phe Val Ile Met 
145                 150                 155                 160 


Gln Ala Lys Glu Gln Tyr Arg Ala Gly Lys Glu Arg Asn Lys Ala Asp 
                165                 170                 175     


Arg Tyr Ala Leu Asp Cys Gln Glu Lys Ala Tyr Trp Leu Val His Arg 
            180                 185                 190         


Cys Pro Pro Gly Met Asp Asn Val Leu Asp Tyr Gly Leu Asp Arg Val 
        195                 200                 205             


Thr Asn Pro Asn Glu Val Lys Lys Gln Thr Val Val Ala Val Lys Lys 
    210                 215                 220                 


Glu Ile Met Tyr Tyr Gln Gln Ala Leu Met Arg Ser Thr Val Lys Ser 
225                 230                 235                 240 


Ser Val Ser Leu Gly Gly Ile Val Lys Tyr Ser Glu Gln Phe Ser Ser 
                245                 250                 255     


Asn Asp Ala Ile Met Ser Gly Cys Leu Pro Ser Asn Pro Trp Ile Thr 
            260                 265                 270         


Asp Asp Thr Gln Phe Trp Asp Leu Asn Ala Lys Leu Val Glu Ile Pro 
        275                 280                 285             


Thr Lys Met Arg Val Glu Arg Trp Ala Phe Asn Phe Ser Glu Leu Ile 
    290                 295                 300                 


Arg Asp Pro Lys Gly Arg Gln Ser Phe Gln Tyr Phe Leu Lys Lys Glu 
305                 310                 315                 320 


Phe Ser Gly Glu Asn Leu Gly Phe Trp Glu Ala Cys Glu Asp Leu Lys 
                325                 330                 335     


Tyr Gly Asp Gln Ser Lys Val Lys Glu Lys Ala Glu Glu Ile Tyr Lys 
            340                 345                 350         


Leu Phe Leu Ala Pro Gly Ala Arg Arg Trp Ile Asn Ile Asp Gly Lys 
        355                 360                 365             


Thr Met Asp Ile Thr Val Lys Gly Leu Lys His Pro His Arg Tyr Val 
    370                 375                 380                 


Leu Asp Ala Ala Gln Thr His Ile Tyr Met Leu Met Lys Lys Asp Ser 
385                 390                 395                 400 


Tyr Ala Arg Tyr Leu Lys Ser Pro Ile Tyr Lys Asp Met Leu Ala Lys 
                405                 410                 415     


Ala Ile Glu Pro Gln Glu Thr Thr Lys Lys Ser Ser Thr Leu Pro Phe 
            420                 425                 430         


Met Arg Arg His Leu Arg Ser Ser Pro Ser Pro Val Ile Leu Arg Gln 
        435                 440                 445             


Leu Glu Glu Glu Ala Lys Ala Arg Glu Ala Ala Asn Thr Val Asp Ile 
    450                 455                 460                 


Thr Gln Pro Gly Gln His Met Ala Pro Ser Pro His Leu Thr Val Tyr 
465                 470                 475                 480 


Thr Gly Thr Cys Met Pro Pro Ser Pro Ser Ser Pro Phe Ser Ser Ser 
                485                 490                 495     


Cys Arg Ser Pro Arg Lys Pro Phe Ala Ser Pro Ser Arg Phe Ile Arg 
            500                 505                 510         


Arg Pro Ser Thr Thr Ile Cys Pro Ser Pro Ile Arg Val Ala Leu Glu 
        515                 520                 525             


Ser Ser Ser Gly Leu Glu Gln Lys Gly Glu Cys Ser Gly Ser Met Ala 
    530                 535                 540                 


Pro Arg Gly Pro Ser Val Thr Glu Ser Ser Glu Ala Ser Leu Asp Thr 
545                 550                 555                 560 


Ser Trp Pro Arg Ser Arg Pro Arg Ala Pro Pro Lys Ala Arg Met Ala 
                565                 570                 575     


Leu Ser Phe Ser Arg Phe Leu Arg Arg Gly Cys Leu Ala Ser Pro Val 
            580                 585                 590         


Phe Ala Arg Leu Ser Pro Lys Cys Pro Ala Val Ser His Gly Arg Val 
        595                 600                 605             


Gln Pro Leu Gly Asp Val Gly Gln Gln Leu Pro Arg Leu Lys Ser Lys 
    610                 615                 620                 


Arg Val Ala Asn Phe Phe Gln Ile Lys Met Asp Val Pro Thr Gly Ser 
625                 630                 635                 640 


Gly Thr Cys Leu Met Asp Ser Glu Asp Ala Gly Thr Gly Glu Ser Gly 
                645                 650                 655     


Asp Arg Ala Thr Glu Lys Glu Val Ile Cys Pro Trp Glu Ser Leu 
            660                 665                 670     


<210>  122
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  122

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         


<210>  123
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu His Glu Phe Leu Ile 
1               5                   10                  15      


Met Arg Ser Pro His Ser Asp Val Gly Cys Ser Ser Asp Glu Asp Gly 
            20                  25                  30          


Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe Leu His Ile Ala Ile 
        35                  40                  45              


Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser His Phe Phe Val His 
    50                  55                  60                  


Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly Glu Gln Leu His Val 
65                  70                  75                  80  


Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile Tyr Ser Ala Asp Tyr 
                85                  90                  95      


Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile Arg Trp Met Pro Pro 
            100                 105                 110         


Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp Ser Asp Ile Trp Ser 
        115                 120                 125             


Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe Gly Leu Gln Pro Tyr 
    130                 135                 140                 


Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met Val Arg Lys Arg Gln 
145                 150                 155                 160 


Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg Met Tyr Ser Leu Met 
                165                 170                 175     


Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg Pro Arg Phe Lys Asp 
            180                 185                 190         


Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu Ser Ser His Thr Ser 
        195                 200                 205             


Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr Gln Thr Thr Ser Leu 
    210                 215                 220                 


Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro Arg Tyr Pro Asn Tyr 
225                 230                 235                 240 


Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly Gln Ile Ala Gly Phe 
                245                 250                 255     


Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe Ile Pro Ile Asn Gly 
            260                 265                 270         


Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro Ala Ala His Tyr Gln 
        275                 280                 285             


Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys Pro Pro Pro Lys Ser 
    290                 295                 300                 


Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser Thr Gly His Val Thr 
305                 310                 315                 320 


Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala Asn Ile Pro Leu Leu 
                325                 330                 335     


Pro His Met Ser Ile Pro Asn His Pro Gly Gly Met Gly Ile Thr Val 
            340                 345                 350         


Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile Asp Ser Lys Gln Ala 
        355                 360                 365             


Ser Leu Leu Gly Asp Ala Asn Ile His Gly His Thr Glu Ser Met Ile 
    370                 375                 380                 


Ser Ala Glu Leu 
385             


<210>  124
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  124

Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Gly Lys 
385                 390             


<210>  125
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Ser Met Leu Pro Thr Phe Gly Phe Thr Gln Glu Gln Val Ala Cys 
1               5                   10                  15      


Val Cys Glu Val Leu Gln Gln Gly Gly Asn Ile Glu Arg Leu Gly Arg 
            20                  25                  30          


Phe Leu Trp Ser Leu Pro Ala Cys Glu His Leu His Lys Asn Glu Ser 
        35                  40                  45              


Val Leu Lys Ala Lys Ala Val Val Ala Phe His Arg Gly Asn Phe Arg 
    50                  55                  60                  


Glu Leu Tyr Lys Ile Leu Glu Ser His Gln Phe Ser Pro His Asn His 
65                  70                  75                  80  


Ala Lys Leu Gln Gln Leu Trp Leu Lys Ala His Tyr Ile Glu Ala Glu 
                85                  90                  95      


Lys Leu Arg Gly Arg Pro Leu Gly Ala Val Gly Lys Tyr Arg Val Arg 
            100                 105                 110         


Arg Lys Phe Pro Leu Pro Arg Ser Ile Trp Asp Gly Glu Glu Thr Ser 
        115                 120                 125             


Tyr Cys Phe Lys Glu Lys Ser Arg Ser Val Leu Arg Glu Trp Tyr Ala 
    130                 135                 140                 


His Asn Pro Tyr Pro Ser Pro Arg Glu Lys Arg Glu Leu Ala Glu Ala 
145                 150                 155                 160 


Thr Gly Leu Thr Thr Thr Gln Val Ser Asn Trp Phe Lys Asn Arg Arg 
                165                 170                 175     


Gln Arg Asp Arg Ala Ala Glu Ala Lys Glu Arg Glu Asn Asn Glu Asn 
            180                 185                 190         


Ser Asn Ser Asn Ser His Asn Pro Leu Asn Gly Ser Gly Lys Ser Val 
        195                 200                 205             


Leu Gly Ser Ser Glu Asp Glu Lys Thr Pro Ser Gly Thr Pro Asp His 
    210                 215                 220                 


Ser Ser Ser Ser Pro Ala Leu Leu Leu Ser Pro Pro Pro Pro Gly Leu 
225                 230                 235                 240 


Pro Ser Leu His Ser Leu Gly His Pro Pro Gly Pro Ser Ala Val Pro 
                245                 250                 255     


Val Pro Val Pro Gly Gly Gly Gly Ala Asp Pro Leu Gln His His His 
            260                 265                 270         


Gly Leu Gln Asp Ser Ile Leu Asn Pro Met Ser Ala Asn Leu Val Asp 
        275                 280                 285             


Leu Gly Ser 
    290     


<210>  126
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ala Pro Ile Thr Thr Ser Arg Glu Glu Phe Asp Glu Ile Pro Thr 
1               5                   10                  15      


Val Val Gly Ile Phe Ser Ala Phe Gly Leu Val Phe Thr Val Ser Leu 
            20                  25                  30          


Phe Ala Trp Ile Cys Cys Gln Arg Lys Ser Ser Lys Ser Asn Lys Thr 
        35                  40                  45              


Pro Pro Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro 
    50                  55                  60                  


Glu Asn Leu Asn Ser Lys Lys Lys Phe Gly Ala Asp Asp Lys Asn Glu 
65                  70                  75                  80  


Val Lys Asn Lys Pro Ala Val Pro Lys Asn Ser Leu His Leu Asp Leu 
                85                  90                  95      


Glu Lys Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Leu Lys Pro 
            100                 105                 110         


Gly Ser Pro Ser Asp Leu Glu Asn Ala Thr Pro Lys Leu Phe Leu Glu 
        115                 120                 125             


Gly Glu Lys Glu Ser Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser 
    130                 135                 140                 


Leu Thr Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Phe Ser 
145                 150                 155                 160 


Leu Glu Tyr Asn Phe Glu Arg Lys Ala Phe Val Val Asn Ile Lys Glu 
                165                 170                 175     


Ala Arg Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro 
            180                 185                 190         


Tyr Ile Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr 
        195                 200                 205             


Arg Val Leu Arg Lys Thr Leu Asp Pro Ala Phe Asp Glu Thr Phe Thr 
    210                 215                 220                 


Phe Tyr Gly Ile Pro Tyr Thr Gln Ile Gln Glu Leu Ala Leu His Phe 
225                 230                 235                 240 


Thr Ile Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Ile Ile Gly Glu 
                245                 250                 255     


Val Leu Ile Pro Leu Ser Gly Ile Glu Leu Ser Glu Gly Lys Met Leu 
            260                 265                 270         


Met Asn Arg Glu Ile Ile Lys Arg Asn Val Arg Lys Ser Ser Gly Arg 
        275                 280                 285             


Gly Glu Leu Leu Ile Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu 
    290                 295                 300                 


Thr Val Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser 
305                 310                 315                 320 


Gly Leu Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys 
                325                 330                 335     


Arg Ile Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala 
            340                 345                 350         


Val Phe Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Gly Leu Glu 
        355                 360                 365             


Asp Ile Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg 
    370                 375                 380                 


Asn Glu Val Ile Gly Gln Leu Val Leu Gly Ala Ala Ala Glu Gly Thr 
385                 390                 395                 400 


Gly Gly Glu His Trp Lys Glu Ile Cys Asp Tyr Pro Arg Arg Gln Ile 
                405                 410                 415     


Ala Lys Trp His Val Leu Cys Asp Gly 
            420                 425 


<210>  127
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Ala Pro Ile Thr Thr Ser Arg Glu Glu Phe Val Ser Leu Phe Ala 
1               5                   10                  15      


Trp Ile Cys Cys Gln Arg Lys Ser Ser Lys Ser Asn Lys Thr Pro Pro 
            20                  25                  30          


Tyr Lys Phe Val His Val Leu Lys Gly Val Asp Ile Tyr Pro Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys Lys Lys Phe Gly Ala Asp Asp Lys Asn Glu Val Lys 
    50                  55                  60                  


Asn Lys Pro Ala Val Pro Lys Asn Ser Leu His Leu Asp Leu Glu Lys 
65                  70                  75                  80  


Arg Asp Leu Asn Gly Asn Phe Pro Lys Thr Asn Leu Lys Pro Gly Ser 
                85                  90                  95      


Pro Ser Asp Leu Glu Asn Ala Thr Pro Lys Leu Phe Leu Glu Gly Glu 
            100                 105                 110         


Lys Glu Ser Val Ser Pro Glu Ser Leu Lys Ser Ser Thr Ser Leu Thr 
        115                 120                 125             


Ser Glu Glu Lys Gln Glu Lys Leu Gly Thr Leu Phe Phe Ser Leu Glu 
    130                 135                 140                 


Tyr Asn Phe Glu Arg Lys Ala Phe Val Val Asn Ile Lys Glu Ala Arg 
145                 150                 155                 160 


Gly Leu Pro Ala Met Asp Glu Gln Ser Met Thr Ser Asp Pro Tyr Ile 
                165                 170                 175     


Lys Met Thr Ile Leu Pro Glu Lys Lys His Lys Val Lys Thr Arg Val 
            180                 185                 190         


Leu Arg Lys Thr Leu Asp Pro Ala Phe Asp Glu Thr Phe Thr Phe Tyr 
        195                 200                 205             


Gly Ile Pro Tyr Thr Gln Ile Gln Glu Leu Ala Leu His Phe Thr Ile 
    210                 215                 220                 


Leu Ser Phe Asp Arg Phe Ser Arg Asp Asp Ile Ile Gly Glu Val Leu 
225                 230                 235                 240 


Ile Pro Leu Ser Gly Ile Glu Leu Ser Glu Gly Lys Met Leu Met Asn 
                245                 250                 255     


Arg Glu Ile Ile Lys Arg Asn Val Arg Lys Ser Ser Gly Arg Gly Glu 
            260                 265                 270         


Leu Leu Ile Ser Leu Cys Tyr Gln Ser Thr Thr Asn Thr Leu Thr Val 
        275                 280                 285             


Val Val Leu Lys Ala Arg His Leu Pro Lys Ser Asp Val Ser Gly Leu 
    290                 295                 300                 


Ser Asp Pro Tyr Val Lys Val Asn Leu Tyr His Ala Lys Lys Arg Ile 
305                 310                 315                 320 


Ser Lys Lys Lys Thr His Val Lys Lys Cys Thr Pro Asn Ala Val Phe 
                325                 330                 335     


Asn Glu Leu Phe Val Phe Asp Ile Pro Cys Glu Gly Leu Glu Asp Ile 
            340                 345                 350         


Ser Val Glu Phe Leu Val Leu Asp Ser Glu Arg Gly Ser Arg Asn Glu 
        355                 360                 365             


Val Ile Gly Gln Leu Val Leu Gly Ala Ala Ala Glu Gly Thr Gly Gly 
    370                 375                 380                 


Glu His Trp Lys Glu Ile Cys Asp Tyr Pro Arg Arg Gln Ile Ala Lys 
385                 390                 395                 400 


Trp His Val Leu Cys Asp Gly 
                405         


<210>  128
<211>  1170
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Asn Arg Ile Pro Glu Ser Gly Gly Asp Asn Ser Val Phe Asp 
            20                  25                  30          


Ile Phe Glu Leu Thr Gly Ala Ala Arg Lys Gly Ser Gly Arg Arg Leu 
        35                  40                  45              


Val Lys Gly Pro Asp Pro Ser Ser Pro Ala Phe Arg Ile Glu Asp Ala 
    50                  55                  60                  


Asn Leu Ile Pro Pro Val Pro Asp Asp Lys Phe Gln Asp Leu Val Asp 
65                  70                  75                  80  


Ala Val Arg Ala Glu Lys Gly Phe Leu Leu Leu Ala Ser Leu Arg Gln 
                85                  90                  95      


Met Lys Lys Thr Arg Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His 
            100                 105                 110         


Ser Gly Gln Val Phe Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu 
        115                 120                 125             


Asp Leu Ser Leu Thr Val Gln Gly Lys Gln His Val Val Ser Val Glu 
    130                 135                 140                 


Glu Ala Leu Leu Ala Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val 
145                 150                 155                 160 


Gln Glu Asp Arg Ala Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn 
                165                 170                 175     


Ala Glu Leu Asp Val Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala 
            180                 185                 190         


Ser Ile Ala Arg Leu Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe 
        195                 200                 205             


Gln Gly Val Leu Gln Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu 
    210                 215                 220                 


Asp Ile Leu Arg Asn Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu 
225                 230                 235                 240 


Thr Leu Asp Asn Asn Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr 
                245                 250                 255     


Asn Tyr Ile Gly His Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile 
            260                 265                 270         


Ser Cys Asp Glu Leu Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg 
        275                 280                 285             


Thr Ile Val Thr Thr Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu 
    290                 295                 300                 


Asn Lys Glu Leu Ala Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His 
305                 310                 315                 320 


Asn Gly Val Gln Tyr Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys 
                325                 330                 335     


Thr Glu Cys His Cys Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser 
            340                 345                 350         


Cys Pro Ile Met Pro Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys 
        355                 360                 365             


Cys Pro Arg Cys Trp Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro 
    370                 375                 380                 


Trp Ser Glu Trp Thr Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln 
385                 390                 395                 400 


Gln Arg Gly Arg Ser Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser 
                405                 410                 415     


Ser Val Gln Thr Arg Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe 
            420                 425                 430         


Lys Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser 
        435                 440                 445             


Val Thr Cys Gly Asp Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser 
    450                 455                 460                 


Pro Ser Pro Gln Met Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu 
465                 470                 475                 480 


Thr Lys Ala Cys Lys Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly 
                485                 490                 495     


Pro Trp Ser Pro Trp Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val 
            500                 505                 510         


Gln Lys Arg Ser Arg Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly 
        515                 520                 525             


Lys Asp Cys Val Gly Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln 
    530                 535                 540                 


Asp Cys Pro Ile Asp Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val 
545                 550                 555                 560 


Lys Cys Thr Ser Tyr Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro 
                565                 570                 575     


Pro Gly Tyr Ser Gly Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys 
            580                 585                 590         


Lys Glu Val Pro Asp Ala Cys Phe Asn His Asn Gly Glu His Arg Cys 
        595                 600                 605             


Glu Asn Thr Asp Pro Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe 
    610                 615                 620                 


Thr Gly Ser Gln Pro Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn 
625                 630                 635                 640 


Lys Gln Val Cys Lys Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp 
                645                 650                 655     


Cys Asn Lys Asn Ala Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro 
            660                 665                 670         


Met Tyr Arg Cys Glu Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile 
        675                 680                 685             


Cys Gly Glu Asp Thr Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val 
    690                 695                 700                 


Cys Val Ala Asn Ala Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn 
705                 710                 715                 720 


Leu Pro Asn Ser Gly Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp 
                725                 730                 735     


Ala Cys Asp Asp Asp Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp 
            740                 745                 750         


Asn Cys Pro Phe His Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp 
        755                 760                 765             


Asp Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp 
    770                 775                 780                 


Gln Ala Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp 
785                 790                 795                 800 


Ile Asp Gly Asp Gly Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val 
                805                 810                 815     


Tyr Asn Val Asp Gln Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln 
            820                 825                 830         


Cys Asp Asn Cys Pro Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp 
        835                 840                 845             


Ser Asp Arg Ile Gly Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu 
    850                 855                 860                 


Asp Gly His Gln Asn Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala 
865                 870                 875                 880 


Asn Gln Ala Asp His Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His 
                885                 890                 895     


Asp Asp Asp Asn Asp Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu 
            900                 905                 910         


Val Pro Asn Pro Asp Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp 
        915                 920                 925             


Ala Cys Lys Asp Asp Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp 
    930                 935                 940                 


Ile Cys Pro Glu Asn Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe 
945                 950                 955                 960 


Gln Met Ile Pro Leu Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn 
                965                 970                 975     


Trp Val Val Arg His Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys 
            980                 985                 990         


Asp Pro Gly Leu Ala Val Gly Tyr  Asp Glu Phe Asn Ala  Val Asp Phe 
        995                 1000                 1005             


Ser Gly  Thr Phe Phe Ile Asn  Thr Glu Arg Asp Asp  Asp Tyr Ala 
    1010                 1015                 1020             


Gly Phe  Val Phe Gly Tyr Gln  Ser Ser Ser Arg Phe  Tyr Val Val 
    1025                 1030                 1035             


Met Trp  Lys Gln Val Thr Gln  Ser Tyr Trp Asp Thr  Asn Pro Thr 
    1040                 1045                 1050             


Arg Ala  Gln Gly Tyr Ser Gly  Leu Ser Val Lys Val  Val Asn Ser 
    1055                 1060                 1065             


Thr Thr  Gly Pro Gly Glu His  Leu Arg Asn Ala Leu  Trp His Thr 
    1070                 1075                 1080             


Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu Trp His  Asp Pro Arg 
    1085                 1090                 1095             


His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr Arg Trp  Arg Leu Ser 
    1100                 1105                 1110             


His Arg  Pro Lys Thr Gly Phe  Ile Arg Val Val Met  Tyr Glu Gly 
    1115                 1120                 1125             


Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile Tyr Asp  Lys Thr Tyr 
    1130                 1135                 1140             


Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe Ser Gln  Glu Met Val 
    1145                 1150                 1155             


Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg Asp Pro  
    1160                 1165                 1170 


<210>  129
<211>  1085
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Gly Leu Ala Trp Gly Leu Gly Val Leu Phe Leu Met His Val Cys 
1               5                   10                  15      


Gly Thr Leu Leu Ala Leu Glu Arg Lys Asp His Ser Gly Gln Val Phe 
            20                  25                  30          


Ser Val Val Ser Asn Gly Lys Ala Gly Thr Leu Asp Leu Ser Leu Thr 
        35                  40                  45              


Val Gln Gly Lys Gln His Val Val Ser Val Glu Glu Ala Leu Leu Ala 
    50                  55                  60                  


Thr Gly Gln Trp Lys Ser Ile Thr Leu Phe Val Gln Glu Asp Arg Ala 
65                  70                  75                  80  


Gln Leu Tyr Ile Asp Cys Glu Lys Met Glu Asn Ala Glu Leu Asp Val 
                85                  90                  95      


Pro Ile Gln Ser Val Phe Thr Arg Asp Leu Ala Ser Ile Ala Arg Leu 
            100                 105                 110         


Arg Ile Ala Lys Gly Gly Val Asn Asp Asn Phe Gln Gly Val Leu Gln 
        115                 120                 125             


Asn Val Arg Phe Val Phe Gly Thr Thr Pro Glu Asp Ile Leu Arg Asn 
    130                 135                 140                 


Lys Gly Cys Ser Ser Ser Thr Ser Val Leu Leu Thr Leu Asp Asn Asn 
145                 150                 155                 160 


Val Val Asn Gly Ser Ser Pro Ala Ile Arg Thr Asn Tyr Ile Gly His 
                165                 170                 175     


Lys Thr Lys Asp Leu Gln Ala Ile Cys Gly Ile Ser Cys Asp Glu Leu 
            180                 185                 190         


Ser Ser Met Val Leu Glu Leu Arg Gly Leu Arg Thr Ile Val Thr Thr 
        195                 200                 205             


Leu Gln Asp Ser Ile Arg Lys Val Thr Glu Glu Asn Lys Glu Leu Ala 
    210                 215                 220                 


Asn Glu Leu Arg Arg Pro Pro Leu Cys Tyr His Asn Gly Val Gln Tyr 
225                 230                 235                 240 


Arg Asn Asn Glu Glu Trp Thr Val Asp Ser Cys Thr Glu Cys His Cys 
                245                 250                 255     


Gln Asn Ser Val Thr Ile Cys Lys Lys Val Ser Cys Pro Ile Met Pro 
            260                 265                 270         


Cys Ser Asn Ala Thr Val Pro Asp Gly Glu Cys Cys Pro Arg Cys Trp 
        275                 280                 285             


Pro Ser Asp Ser Ala Asp Asp Gly Trp Ser Pro Trp Ser Glu Trp Thr 
    290                 295                 300                 


Ser Cys Ser Thr Ser Cys Gly Asn Gly Ile Gln Gln Arg Gly Arg Ser 
305                 310                 315                 320 


Cys Asp Ser Leu Asn Asn Arg Cys Glu Gly Ser Ser Val Gln Thr Arg 
                325                 330                 335     


Thr Cys His Ile Gln Glu Cys Asp Lys Arg Phe Lys Gln Asp Gly Gly 
            340                 345                 350         


Trp Ser His Trp Ser Pro Trp Ser Ser Cys Ser Val Thr Cys Gly Asp 
        355                 360                 365             


Gly Val Ile Thr Arg Ile Arg Leu Cys Asn Ser Pro Ser Pro Gln Met 
    370                 375                 380                 


Asn Gly Lys Pro Cys Glu Gly Glu Ala Arg Glu Thr Lys Ala Cys Lys 
385                 390                 395                 400 


Lys Asp Ala Cys Pro Ile Asn Gly Gly Trp Gly Pro Trp Ser Pro Trp 
                405                 410                 415     


Asp Ile Cys Ser Val Thr Cys Gly Gly Gly Val Gln Lys Arg Ser Arg 
            420                 425                 430         


Leu Cys Asn Asn Pro Thr Pro Gln Phe Gly Gly Lys Asp Cys Val Gly 
        435                 440                 445             


Asp Val Thr Glu Asn Gln Ile Cys Asn Lys Gln Asp Cys Pro Ile Asp 
    450                 455                 460                 


Gly Cys Leu Ser Asn Pro Cys Phe Ala Gly Val Lys Cys Thr Ser Tyr 
465                 470                 475                 480 


Pro Asp Gly Ser Trp Lys Cys Gly Ala Cys Pro Pro Gly Tyr Ser Gly 
                485                 490                 495     


Asn Gly Ile Gln Cys Thr Asp Val Asp Glu Cys Lys Glu Val Pro Asp 
            500                 505                 510         


Ala Cys Phe Asn His Asn Gly Glu His Arg Cys Glu Asn Thr Asp Pro 
        515                 520                 525             


Gly Tyr Asn Cys Leu Pro Cys Pro Pro Arg Phe Thr Gly Ser Gln Pro 
    530                 535                 540                 


Phe Gly Gln Gly Val Glu His Ala Thr Ala Asn Lys Gln Val Cys Lys 
545                 550                 555                 560 


Pro Arg Asn Pro Cys Thr Asp Gly Thr His Asp Cys Asn Lys Asn Ala 
                565                 570                 575     


Lys Cys Asn Tyr Leu Gly His Tyr Ser Asp Pro Met Tyr Arg Cys Glu 
            580                 585                 590         


Cys Lys Pro Gly Tyr Ala Gly Asn Gly Ile Ile Cys Gly Glu Asp Thr 
        595                 600                 605             


Asp Leu Asp Gly Trp Pro Asn Glu Asn Leu Val Cys Val Ala Asn Ala 
    610                 615                 620                 


Thr Tyr His Cys Lys Lys Asp Asn Cys Pro Asn Leu Pro Asn Ser Gly 
625                 630                 635                 640 


Gln Glu Asp Tyr Asp Lys Asp Gly Ile Gly Asp Ala Cys Asp Asp Asp 
                645                 650                 655     


Asp Asp Asn Asp Lys Ile Pro Asp Asp Arg Asp Asn Cys Pro Phe His 
            660                 665                 670         


Tyr Asn Pro Ala Gln Tyr Asp Tyr Asp Arg Asp Asp Val Gly Asp Arg 
        675                 680                 685             


Cys Asp Asn Cys Pro Tyr Asn His Asn Pro Asp Gln Ala Asp Thr Asp 
    690                 695                 700                 


Asn Asn Gly Glu Gly Asp Ala Cys Ala Ala Asp Ile Asp Gly Asp Gly 
705                 710                 715                 720 


Ile Leu Asn Glu Arg Asp Asn Cys Gln Tyr Val Tyr Asn Val Asp Gln 
                725                 730                 735     


Arg Asp Thr Asp Met Asp Gly Val Gly Asp Gln Cys Asp Asn Cys Pro 
            740                 745                 750         


Leu Glu His Asn Pro Asp Gln Leu Asp Ser Asp Ser Asp Arg Ile Gly 
        755                 760                 765             


Asp Thr Cys Asp Asn Asn Gln Asp Ile Asp Glu Asp Gly His Gln Asn 
    770                 775                 780                 


Asn Leu Asp Asn Cys Pro Tyr Val Pro Asn Ala Asn Gln Ala Asp His 
785                 790                 795                 800 


Asp Lys Asp Gly Lys Gly Asp Ala Cys Asp His Asp Asp Asp Asn Asp 
                805                 810                 815     


Gly Ile Pro Asp Asp Lys Asp Asn Cys Arg Leu Val Pro Asn Pro Asp 
            820                 825                 830         


Gln Lys Asp Ser Asp Gly Asp Gly Arg Gly Asp Ala Cys Lys Asp Asp 
        835                 840                 845             


Phe Asp His Asp Ser Val Pro Asp Ile Asp Asp Ile Cys Pro Glu Asn 
    850                 855                 860                 


Val Asp Ile Ser Glu Thr Asp Phe Arg Arg Phe Gln Met Ile Pro Leu 
865                 870                 875                 880 


Asp Pro Lys Gly Thr Ser Gln Asn Asp Pro Asn Trp Val Val Arg His 
                885                 890                 895     


Gln Gly Lys Glu Leu Val Gln Thr Val Asn Cys Asp Pro Gly Leu Ala 
            900                 905                 910         


Val Gly Tyr Asp Glu Phe Asn Ala Val Asp Phe Ser Gly Thr Phe Phe 
        915                 920                 925             


Ile Asn Thr Glu Arg Asp Asp Asp Tyr Ala Gly Phe Val Phe Gly Tyr 
    930                 935                 940                 


Gln Ser Ser Ser Arg Phe Tyr Val Val Met Trp Lys Gln Val Thr Gln 
945                 950                 955                 960 


Ser Tyr Trp Asp Thr Asn Pro Thr Arg Ala Gln Gly Tyr Ser Gly Leu 
                965                 970                 975     


Ser Val Lys Val Val Asn Ser Thr Thr Gly Pro Gly Glu His Leu Arg 
            980                 985                 990         


Asn Ala Leu Trp His Thr Gly Asn  Thr Pro Gly Gln Val  Arg Thr Leu 
        995                 1000                 1005             


Trp His  Asp Pro Arg His Ile  Gly Trp Lys Asp Phe  Thr Ala Tyr 
    1010                 1015                 1020             


Arg Trp  Arg Leu Ser His Arg  Pro Lys Thr Gly Phe  Ile Arg Val 
    1025                 1030                 1035             


Val Met  Tyr Glu Gly Lys Lys  Ile Met Ala Asp Ser  Gly Pro Ile 
    1040                 1045                 1050             


Tyr Asp  Lys Thr Tyr Ala Gly  Gly Arg Leu Gly Leu  Phe Val Phe 
    1055                 1060                 1065             


Ser Gln  Glu Met Val Phe Phe  Ser Asp Leu Lys Tyr  Glu Cys Arg 
    1070                 1075                 1080             


Asp Pro  
    1085 


<210>  130
<211>  710
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe 
1               5                   10                  15      


Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala 
            20                  25                  30          


Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln 
        35                  40                  45              


Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp 
    50                  55                  60                  


Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser 
65                  70                  75                  80  


Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro 
                85                  90                  95      


Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His 
            100                 105                 110         


Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys 
        115                 120                 125             


Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly 
    130                 135                 140                 


Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln 
145                 150                 155                 160 


Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys 
                165                 170                 175     


Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro 
            180                 185                 190         


Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg 
        195                 200                 205             


Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg 
    210                 215                 220                 


Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr 
225                 230                 235                 240 


Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly 
                245                 250                 255     


Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu 
            260                 265                 270         


His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala 
        275                 280                 285             


Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln 
    290                 295                 300                 


Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys 
305                 310                 315                 320 


Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala 
                325                 330                 335     


Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln 
            340                 345                 350         


Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu 
        355                 360                 365             


Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln 
    370                 375                 380                 


Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp 
385                 390                 395                 400 


Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser 
                405                 410                 415     


Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val 
            420                 425                 430         


Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu 
        435                 440                 445             


Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln 
    450                 455                 460                 


Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp 
465                 470                 475                 480 


Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr 
                485                 490                 495     


Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg 
            500                 505                 510         


Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu 
        515                 520                 525             


Val Leu Gln Thr Ser Glu Val Ala Trp Phe Ala Phe Asp Pro Gly Ser 
    530                 535                 540                 


Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr Cys 
545                 550                 555                 560 


Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser Lys 
                565                 570                 575     


Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His Pro 
            580                 585                 590         


Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val Met 
        595                 600                 605             


Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn Arg 
    610                 615                 620                 


Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly Gly 
625                 630                 635                 640 


Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Leu Asn Arg Lys 
                645                 650                 655     


Asn Leu Thr Phe Phe Ile Asn Asp Glu Gln Gln Gly Pro Ile Ala Phe 
            660                 665                 670         


Asp Asn Val Glu Gly Leu Phe Phe Pro Ala Val Ser Leu Asn Arg Asn 
        675                 680                 685             


Val Gln Val Thr Leu His Thr Gly Leu Pro Val Pro Asp Phe Tyr Ser 
    690                 695                 700                 


Ser Arg Ala Ser Ile Ala 
705                 710 


<210>  131
<211>  802
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe 
1               5                   10                  15      


Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala 
            20                  25                  30          


Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln 
        35                  40                  45              


Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp 
    50                  55                  60                  


Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser 
65                  70                  75                  80  


Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro 
                85                  90                  95      


Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His 
            100                 105                 110         


Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys 
        115                 120                 125             


Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly 
    130                 135                 140                 


Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln 
145                 150                 155                 160 


Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys 
                165                 170                 175     


Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro 
            180                 185                 190         


Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg 
        195                 200                 205             


Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg 
    210                 215                 220                 


Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr 
225                 230                 235                 240 


Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly 
                245                 250                 255     


Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu 
            260                 265                 270         


His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala 
        275                 280                 285             


Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln 
    290                 295                 300                 


Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys 
305                 310                 315                 320 


Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala 
                325                 330                 335     


Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln 
            340                 345                 350         


Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu 
        355                 360                 365             


Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln 
    370                 375                 380                 


Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp 
385                 390                 395                 400 


Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser 
                405                 410                 415     


Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val 
            420                 425                 430         


Gln Val Lys Val Pro Ala Thr Pro Ile Leu Gln Leu Glu Glu Cys Cys 
        435                 440                 445             


Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln Pro Pro Leu Ser 
    450                 455                 460                 


Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp Asp Gly Asn Gly 
465                 470                 475                 480 


Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr Met Cys Thr Val 
                485                 490                 495     


Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg Val Lys Ala Phe 
            500                 505                 510         


Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu Val Leu Gln Thr 
        515                 520                 525             


Ser Glu Asp Thr Asp Ser Glu Glu Gln Thr Leu Pro Phe Pro Val Pro 
    530                 535                 540                 


Ser Glu Arg Leu Pro Leu Arg Arg Met Ser Pro Phe Ser Ser Thr Leu 
545                 550                 555                 560 


Asn Leu Gln Pro Ser Phe Pro Gly Arg Ser Tyr Phe Asp Phe Arg Ser 
                565                 570                 575     


Ser Pro His Gln Leu Ser Leu His Ser Ser Leu Gln Ser Leu Asn Ala 
            580                 585                 590         


Pro Gly Cys Asn Phe Glu Thr Gln Ser Ala Pro Tyr Ser Gln Leu Val 
        595                 600                 605             


Asp Ile Lys Lys Leu Leu Ala Val Ala Trp Phe Ala Phe Asp Pro Gly 
    610                 615                 620                 


Ser Ala His Ser Asp Ile Ile Leu Ser Asn Asp Asn Leu Thr Val Thr 
625                 630                 635                 640 


Cys Ser Ser Tyr Asp Asp Arg Val Val Leu Gly Lys Thr Gly Phe Ser 
                645                 650                 655     


Lys Gly Ile His Tyr Trp Glu Leu Thr Val Asp Arg Tyr Asp Asn His 
            660                 665                 670         


Pro Asp Pro Ala Phe Gly Val Ala Arg Met Asp Val Met Lys Asp Val 
        675                 680                 685             


Met Leu Gly Lys Asp Asp Lys Ala Trp Ala Met Tyr Val Asp Asn Asn 
    690                 695                 700                 


Arg Ser Trp Phe Met His Asn Asn Ser His Thr Asn Arg Thr Glu Gly 
705                 710                 715                 720 


Gly Ile Thr Lys Gly Ala Thr Ile Gly Val Leu Leu Asp Leu Asn Arg 
                725                 730                 735     


Lys Asn Leu Thr Phe Phe Ile Asn Asp Glu Gln Gln Gly Pro Ile Ala 
            740                 745                 750         


Phe Asp Asn Val Glu Gly Leu Phe Phe Pro Ala Val Ser Leu Asn Arg 
        755                 760                 765             


Asn Val Gln Val Ser Thr Leu Pro Leu Arg Leu Asn Ser Cys Cys Trp 
    770                 775                 780                 


Leu Pro Val Gln Arg Leu Pro Arg Ala Val Gln Ser Asn Arg Arg Glu 
785                 790                 795                 800 


Gly Ser 
        


<210>  132
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Glu Glu Met Glu Glu Glu Leu Lys Cys Pro Val Cys Gly Ser Phe 
1               5                   10                  15      


Tyr Arg Glu Pro Ile Ile Leu Pro Cys Ser His Asn Leu Cys Gln Ala 
            20                  25                  30          


Cys Ala Arg Asn Ile Leu Val Gln Thr Pro Glu Ser Glu Ser Pro Gln 
        35                  40                  45              


Ser His Arg Ala Ala Gly Ser Gly Val Ser Asp Tyr Asp Tyr Leu Asp 
    50                  55                  60                  


Leu Asp Lys Met Ser Leu Tyr Ser Glu Ala Asp Ser Gly Tyr Gly Ser 
65                  70                  75                  80  


Tyr Gly Gly Phe Ala Ser Ala Pro Thr Thr Pro Cys Gln Lys Ser Pro 
                85                  90                  95      


Asn Gly Val Arg Val Phe Pro Pro Ala Met Pro Pro Pro Ala Thr His 
            100                 105                 110         


Leu Ser Pro Ala Leu Ala Pro Val Pro Arg Asn Ser Cys Ile Thr Cys 
        115                 120                 125             


Pro Gln Cys His Arg Ser Leu Ile Leu Asp Asp Arg Gly Leu Arg Gly 
    130                 135                 140                 


Phe Pro Lys Asn Arg Val Leu Glu Gly Val Ile Asp Arg Tyr Gln Gln 
145                 150                 155                 160 


Ser Lys Ala Ala Ala Leu Lys Cys Gln Leu Cys Glu Lys Ala Pro Lys 
                165                 170                 175     


Glu Ala Thr Val Met Cys Glu Gln Cys Asp Val Phe Tyr Cys Asp Pro 
            180                 185                 190         


Cys Arg Leu Arg Cys His Pro Pro Arg Gly Pro Leu Ala Lys His Arg 
        195                 200                 205             


Leu Val Pro Pro Ala Gln Gly Arg Val Ser Arg Arg Leu Ser Pro Arg 
    210                 215                 220                 


Lys Val Ser Thr Cys Thr Asp His Glu Leu Glu Asn His Ser Met Tyr 
225                 230                 235                 240 


Cys Val Gln Cys Lys Met Pro Val Cys Tyr Gln Cys Leu Glu Glu Gly 
                245                 250                 255     


Lys His Ser Ser His Glu Val Lys Ala Leu Gly Ala Met Trp Lys Leu 
            260                 265                 270         


His Lys Ser Gln Leu Ser Gln Ala Leu Asn Gly Leu Ser Asp Arg Ala 
        275                 280                 285             


Lys Glu Ala Lys Glu Phe Leu Val Gln Leu Arg Asn Met Val Gln Gln 
    290                 295                 300                 


Ile Gln Glu Asn Ser Val Glu Phe Glu Ala Cys Leu Val Ala Gln Cys 
305                 310                 315                 320 


Asp Ala Leu Ile Asp Ala Leu Asn Arg Arg Lys Ala Gln Leu Leu Ala 
                325                 330                 335     


Arg Val Asn Lys Glu His Glu His Lys Leu Lys Val Val Arg Asp Gln 
            340                 345                 350         


Ile Ser His Cys Thr Val Lys Leu Arg Gln Thr Thr Gly Leu Met Glu 
        355                 360                 365             


Tyr Cys Leu Glu Val Ile Lys Glu Asn Asp Pro Ser Gly Phe Leu Gln 
    370                 375                 380                 


Ile Ser Asp Ala Leu Ile Arg Arg Val His Leu Thr Glu Asp Gln Trp 
385                 390                 395                 400 


Gly Lys Gly Thr Leu Thr Pro Arg Met Thr Thr Asp Phe Asp Leu Ser 
                405                 410                 415     


Leu Asp Asn Ser Pro Leu Leu Gln Ser Ile His Gln Leu Asp Phe Val 
            420                 425                 430         


Gln Val Lys Ala Ser Ser Pro Val Pro Ala Thr Pro Ile Leu Gln Leu 
        435                 440                 445             


Glu Glu Cys Cys Thr His Asn Asn Ser Ala Thr Leu Ser Trp Lys Gln 
    450                 455                 460                 


Pro Pro Leu Ser Thr Val Pro Ala Asp Gly Tyr Ile Leu Glu Leu Asp 
465                 470                 475                 480 


Asp Gly Asn Gly Gly Gln Phe Arg Glu Val Tyr Val Gly Lys Glu Thr 
                485                 490                 495     


Met Cys Thr Val Asp Gly Leu His Phe Asn Ser Thr Tyr Asn Ala Arg 
            500                 505                 510         


Val Lys Ala Phe Asn Lys Thr Gly Val Ser Pro Tyr Ser Lys Thr Leu 
        515                 520                 525             


Val Leu Gln Thr Ser Glu Gly Lys Ala Leu Gln Gln Tyr Pro Ser Glu 
    530                 535                 540                 


Arg Glu Leu Arg Gly Ile 
545                 550 


<210>  133
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val 
                645                 650                 655     


Phe Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu 
            660                 665                 670         


Ala Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg 
        675                 680                 685             


Asn Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His 
    690                 695                 700                 


Gln Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser 
705                 710                 715                 720 


Arg Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala 
                725                 730                 735     


Arg His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro 
            740                 745                 750         


Pro Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg 
        755                 760                 765             


Gln Ala Pro Lys Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro 
    770                 775                 780                 


Pro Val Lys Pro Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly 
785                 790                 795                 800 


Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro Ile Gln Arg Lys Gln 
                805                 810                 815     


Gly Ala Gly Ala Pro Thr Ala Pro 
            820                 


<210>  134
<211>  733
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Gly 
1               5                   10                  15      


Pro Ala Pro Arg Glu Gly Glu Leu Arg Pro Trp Gly His Arg Ala Gln 
            20                  25                  30          


Leu His Pro Pro Pro Ala Glu Glu Gln Gly Pro Ala Gly Leu Arg Leu 
        35                  40                  45              


His Arg Asp Leu Tyr Gly Cys Gln Trp Leu Arg Gly Asp Gly Ala Ala 
    50                  55                  60                  


Ser Arg Ala Gly Pro Leu Leu Leu Pro Gly Pro Arg Arg Gly Val Pro 
65                  70                  75                  80  


Gly Leu Ser Arg Gln Pro Gln His Leu Cys Arg Pro Gln Val Gly Ser 
                85                  90                  95      


Asp Leu His Leu Ile Glu Pro Leu Asp Glu Gly Gly Glu Gly Gly Arg 
            100                 105                 110         


His Ala Val Tyr Gln Ala Glu His Leu Leu Gln Thr Ala Gly Thr Cys 
        115                 120                 125             


Gly Val Ser Asp Asp Ser Leu Gly Ser Leu Leu Gly Pro Arg Thr Ala 
    130                 135                 140                 


Ala Val Phe Arg Pro Arg Pro Gly Asp Ser Leu Pro Ser Arg Glu Thr 
145                 150                 155                 160 


Arg Tyr Val Glu Leu Tyr Val Val Val Asp Asn Ala Glu Phe Gln Met 
                165                 170                 175     


Leu Gly Ser Glu Ala Ala Val Arg His Arg Val Leu Glu Val Val Asn 
            180                 185                 190         


His Val Asp Lys Leu Tyr Gln Lys Leu Asn Phe Arg Val Val Leu Val 
        195                 200                 205             


Gly Leu Glu Ile Trp Asn Ser Gln Asp Arg Phe His Val Ser Pro Asp 
    210                 215                 220                 


Pro Ser Val Thr Leu Glu Asn Leu Leu Thr Trp Gln Ala Arg Gln Arg 
225                 230                 235                 240 


Thr Arg Arg His Leu His Asp Asn Val Gln Leu Ile Thr Gly Val Asp 
                245                 250                 255     


Phe Thr Gly Thr Thr Val Gly Phe Ala Arg Val Ser Ala Met Cys Ser 
            260                 265                 270         


His Ser Ser Gly Ala Val Asn Gln Asp His Ser Lys Asn Pro Val Gly 
        275                 280                 285             


Val Ala Cys Thr Met Ala His Glu Met Gly His Asn Leu Gly Met Asp 
    290                 295                 300                 


His Asp Glu Asn Val Gln Gly Cys Arg Cys Gln Glu Arg Phe Glu Ala 
305                 310                 315                 320 


Gly Arg Cys Ile Met Ala Gly Ser Ile Gly Ser Ser Phe Pro Arg Met 
                325                 330                 335     


Phe Ser Asp Cys Ser Gln Ala Tyr Leu Glu Ser Phe Leu Glu Arg Pro 
            340                 345                 350         


Gln Ser Val Cys Leu Ala Asn Ala Pro Asp Leu Ser His Leu Val Gly 
        355                 360                 365             


Gly Pro Val Cys Gly Asn Leu Phe Val Glu Arg Gly Glu Gln Cys Asp 
    370                 375                 380                 


Cys Gly Pro Pro Glu Asp Cys Arg Asn Arg Cys Cys Asn Ser Thr Thr 
385                 390                 395                 400 


Cys Gln Leu Ala Glu Gly Ala Gln Cys Ala His Gly Thr Cys Cys Gln 
                405                 410                 415     


Glu Cys Lys Val Lys Pro Ala Gly Glu Leu Cys Arg Pro Lys Lys Asp 
            420                 425                 430         


Met Cys Asp Leu Glu Glu Phe Cys Asp Gly Arg His Pro Glu Cys Pro 
        435                 440                 445             


Glu Asp Ala Phe Gln Glu Asn Gly Thr Pro Cys Ser Gly Gly Tyr Cys 
    450                 455                 460                 


Tyr Asn Gly Ala Cys Pro Thr Leu Ala Gln Gln Cys Gln Ala Phe Trp 
465                 470                 475                 480 


Gly Pro Gly Gly Gln Ala Ala Glu Glu Ser Cys Phe Ser Tyr Asp Ile 
                485                 490                 495     


Leu Pro Gly Cys Lys Ala Ser Arg Tyr Arg Ala Asp Met Cys Gly Val 
            500                 505                 510         


Leu Gln Cys Lys Gly Gly Gln Gln Pro Leu Gly Arg Ala Ile Cys Ile 
        515                 520                 525             


Val Asp Val Cys His Ala Leu Thr Thr Glu Asp Gly Thr Ala Tyr Glu 
    530                 535                 540                 


Pro Val Pro Glu Gly Thr Arg Cys Gly Pro Glu Lys Val Cys Asn His 
545                 550                 555                 560 


Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys Ala 
                565                 570                 575     


Lys Leu Leu Thr Glu Val His Ala Ala Ser Gly Ser Leu Pro Val Phe 
            580                 585                 590         


Val Val Val Val Leu Val Leu Leu Ala Val Val Leu Val Thr Leu Ala 
        595                 600                 605             


Gly Ile Ile Val Tyr Arg Lys Ala Arg Ser Arg Ile Leu Ser Arg Asn 
    610                 615                 620                 


Val Ala Pro Lys Thr Thr Met Gly Arg Ser Asn Pro Leu Phe His Gln 
625                 630                 635                 640 


Ala Ala Ser Arg Val Pro Ala Lys Gly Gly Ala Pro Ala Pro Ser Arg 
                645                 650                 655     


Gly Pro Gln Glu Leu Val Pro Thr Thr His Pro Gly Gln Pro Ala Arg 
            660                 665                 670         


His Pro Ala Ser Ser Val Ala Leu Lys Arg Pro Pro Pro Ala Pro Pro 
        675                 680                 685             


Val Thr Val Ser Ser Pro Pro Phe Pro Val Pro Val Tyr Thr Arg Gln 
    690                 695                 700                 


Ala Pro Lys Gln Gly Ala Val Gly Pro Lys Val Ala Leu Lys Pro Pro 
705                 710                 715                 720 


Ile Gln Arg Lys Gln Gly Ala Gly Ala Pro Thr Ala Pro 
                725                 730             


<210>  135
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Arg Gly Leu Gly Leu Trp Leu Leu Gly Ala Met Met Leu Pro Ala 
1               5                   10                  15      


Ile Ala Pro Ser Arg Pro Trp Ala Leu Met Glu Gln Tyr Glu Val Val 
            20                  25                  30          


Leu Pro Trp Arg Leu Pro Gly Pro Arg Val Arg Arg Ala Leu Pro Ser 
        35                  40                  45              


His Leu Gly Leu His Pro Glu Arg Val Ser Tyr Val Leu Gly Ala Thr 
    50                  55                  60                  


Gly His Asn Phe Thr Leu His Leu Arg Lys Asn Arg Asp Leu Leu Gly 
65                  70                  75                  80  


Ser Gly Tyr Thr Glu Thr Tyr Thr Ala Ala Asn Gly Ser Glu Val Thr 
                85                  90                  95      


Glu Gln Pro Arg Gly Gln Asp His Cys Phe Tyr Gln Gly His Val Glu 
            100                 105                 110         


Gly Tyr Pro Asp Ser Ala Ala Ser Leu Ser Thr Cys Ala Gly Leu Arg 
        115                 120                 125             


Gly Phe Phe Gln Val Gly Ser Asp Leu His Leu Ile Glu Pro Leu Asp 
    130                 135                 140                 


Glu Gly Gly Glu Gly Gly Arg His Ala Val Tyr Gln Ala Glu His Leu 
145                 150                 155                 160 


Leu Gln Thr Ala Gly Thr Cys Gly Val Ser Asp Asp Ser Leu Gly Ser 
                165                 170                 175     


Leu Leu Gly Pro Arg Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp 
            180                 185                 190         


Ser Leu Pro Ser Arg Glu Thr Arg Tyr Val Glu Leu Tyr Val Val Val 
        195                 200                 205             


Asp Asn Ala Glu Phe Gln Met Leu Gly Ser Glu Ala Ala Val Arg His 
    210                 215                 220                 


Arg Val Leu Glu Val Val Asn His Val Asp Lys Leu Tyr Gln Lys Leu 
225                 230                 235                 240 


Asn Phe Arg Val Val Leu Val Gly Leu Glu Ile Trp Asn Ser Gln Asp 
                245                 250                 255     


Arg Phe His Val Ser Pro Asp Pro Ser Val Thr Leu Glu Asn Leu Leu 
            260                 265                 270         


Thr Trp Gln Ala Arg Gln Arg Thr Arg Arg His Leu His Asp Asn Val 
        275                 280                 285             


Gln Leu Ile Thr Gly Val Asp Phe Thr Gly Thr Thr Val Gly Phe Ala 
    290                 295                 300                 


Arg Val Ser Ala Met Cys Ser His Ser Ser Gly Ala Val Asn Gln Asp 
305                 310                 315                 320 


His Ser Lys Asn Pro Val Gly Val Ala Cys Thr Met Ala His Glu Met 
                325                 330                 335     


Gly His Asn Leu Gly Met Asp His Asp Glu Asn Val Gln Gly Cys Arg 
            340                 345                 350         


Cys Gln Glu Arg Phe Glu Ala Gly Arg Cys Ile Met Ala Gly Ser Ile 
        355                 360                 365             


Gly Ser Ser Phe Pro Arg Met Phe Ser Asp Cys Ser Gln Ala Tyr Leu 
    370                 375                 380                 


Glu Ser Phe Leu Glu Arg Pro Gln Ser Val Cys Leu Ala Asn Ala Pro 
385                 390                 395                 400 


Asp Leu Ser His Leu Val Gly Gly Pro Val Cys Gly Asn Leu Phe Val 
                405                 410                 415     


Glu Arg Gly Glu Gln Cys Asp Cys Gly Pro Pro Glu Asp Cys Arg Asn 
            420                 425                 430         


Arg Cys Cys Asn Ser Thr Thr Cys Gln Leu Ala Glu Gly Ala Gln Cys 
        435                 440                 445             


Ala His Gly Thr Cys Cys Gln Glu Cys Lys Val Lys Pro Ala Gly Glu 
    450                 455                 460                 


Leu Cys Arg Pro Lys Lys Asp Met Cys Asp Leu Glu Glu Phe Cys Asp 
465                 470                 475                 480 


Gly Arg His Pro Glu Cys Pro Glu Asp Ala Phe Gln Glu Asn Gly Thr 
                485                 490                 495     


Pro Cys Ser Gly Gly Tyr Cys Tyr Asn Gly Ala Cys Pro Thr Leu Ala 
            500                 505                 510         


Gln Gln Cys Gln Ala Phe Trp Gly Pro Gly Gly Gln Ala Ala Glu Glu 
        515                 520                 525             


Ser Cys Phe Ser Tyr Asp Ile Leu Pro Gly Cys Lys Ala Ser Arg Tyr 
    530                 535                 540                 


Arg Ala Asp Met Cys Gly Val Leu Gln Cys Lys Gly Gly Gln Gln Pro 
545                 550                 555                 560 


Leu Gly Arg Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr 
                565                 570                 575     


Glu Asp Gly Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg Cys Gly 
            580                 585                 590         


Pro Glu Lys Val Cys Trp Lys Gly Arg Cys Gln Asp Leu His Val Tyr 
        595                 600                 605             


Arg Ser Ser Asn Cys Ser Ala Gln Cys His Asn His Gly Val Cys Asn 
    610                 615                 620                 


His Lys Gln Glu Cys His Cys His Ala Gly Trp Ala Pro Pro His Cys 
625                 630                 635                 640 


Ala Lys Leu Leu Thr Glu Val His Ala Gly Cys Gln Pro Arg Ala Gly 
                645                 650                 655     


Gln Gly Arg Gly Ser Ser Pro Ile Gln Gly Pro Pro Arg Ala Gly Pro 
            660                 665                 670         


His His Pro Pro Gly Pro Ala Arg Pro Thr Pro Gly Leu Leu Gly Gly 
        675                 680                 685             


Ser Glu Glu Ala Ala Pro Cys Ser Ser Gly His Cys Val Gln Pro Thr 
    690                 695                 700                 


Leu Pro Ser Ser Cys Leu His Pro Ala Gly Thr Lys Ala Gly His Gln 
705                 710                 715                 720 


Ala Asn Val Arg Thr Pro Ser Ala Pro Ser Gln Thr Arg Gly Trp Cys 
                725                 730                 735     


Gly Gln Pro Trp Ser Ser 
            740         


<210>  136
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ser Leu Gln Arg Leu Leu Gln His Ser Ser Asn Gly Asn Leu Ala 
1               5                   10                  15      


Asp Phe Cys Ala Gly Pro Ala Tyr Ser Ser Tyr Ser Thr Leu Thr Gly 
            20                  25                  30          


Ser Leu Thr Met Asp Asp Asn Arg Arg Ile Gln Met Leu Ala Asp Thr 
        35                  40                  45              


Val Ala Thr Leu Pro Arg Gly Arg Lys Gln Leu Ala Leu Thr Arg Ser 
    50                  55                  60                  


Ser Ser Leu Ser Asp Phe Ser Trp Ser Gln Arg Lys Leu Val Thr Val 
65                  70                  75                  80  


Glu Lys Gln Asp Asn Glu Thr Phe Gly Phe Glu Ile Gln Ser Tyr Arg 
                85                  90                  95      


Pro Gln Asn Gln Asn Ala Cys Ser Ser Glu Met Phe Thr Leu Ile Cys 
            100                 105                 110         


Lys Ile Gln Glu Asp Ser Pro Ala His Cys Ala Gly Leu Gln Ala Gly 
        115                 120                 125             


Asp Val Leu Ala Asn Ile Asn Gly Val Ser Thr Glu Gly Phe Thr Tyr 
    130                 135                 140                 


Lys Gln Val Val Asp Leu Ile Arg Ser Ser Gly Asn Leu Leu Thr Ile 
145                 150                 155                 160 


Glu Thr Leu Asn Gly Thr Met Ile Leu Lys Arg Thr Glu Leu Glu Ala 
                165                 170                 175     


Lys Leu Gln Val Leu Lys Gln Thr Leu Lys Gln Lys Trp Val Glu Tyr 
            180                 185                 190         


Arg Ser Leu Gln Leu Gln Glu His Arg Leu Leu His Gly Asp Ala Ala 
        195                 200                 205             


Asn Cys Pro Ser Leu Glu Asn Met Asp Leu Asp Glu Leu Ser Leu Phe 
    210                 215                 220                 


Gly Pro Leu Pro Gly Pro Gly Pro Ala Leu Val Asp Arg Asn Arg Leu 
225                 230                 235                 240 


Ser Ser Glu Ser Ser Cys Lys Ser Trp Leu Ser Ser Met Thr Met Asp 
                245                 250                 255     


Ser Glu Asp Gly Tyr Gln Thr Cys Val Ser Glu Asp Ser Ser Arg Gly 
            260                 265                 270         


Ala Phe Ser Arg Gln Thr Ser Thr Asp Asp Glu Cys Phe Ile Pro Lys 
        275                 280                 285             


Glu Gly Asp Asp Phe Leu Arg Arg Ser Ser Ser Arg Arg Asn Arg Ser 
    290                 295                 300                 


Ile Ser Asn Thr Ser Ser Gly Ser Met Ser Pro Leu Trp Glu Gly Asn 
305                 310                 315                 320 


Leu Ser Ser Met Phe Gly Thr Leu Pro Arg Lys Ser Arg Lys Gly Ser 
                325                 330                 335     


Val Arg Lys Gln Leu Leu Lys Phe Ile Pro Gly Leu His Arg Ala Val 
            340                 345                 350         


Glu Glu Glu Glu Ser Arg Phe 
        355                 


<210>  137
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Phe Thr Leu Ile Cys Lys Ile Gln Glu Asp Ser Pro Ala His Cys 
1               5                   10                  15      


Ala Gly Leu Gln Ala Gly Asp Val Leu Ala Asn Ile Asn Gly Val Ser 
            20                  25                  30          


Thr Glu Gly Phe Thr Tyr Lys Gln Val Val Asp Leu Ile Arg Ser Ser 
        35                  40                  45              


Gly Asn Leu Leu Thr Ile Glu Thr Leu Asn Gly Thr Met Ile Leu Lys 
    50                  55                  60                  


Arg Thr Glu Leu Glu Ala Lys Leu Gln Val Leu Lys Gln Thr Leu Lys 
65                  70                  75                  80  


Gln Lys Trp Val Glu Tyr Arg Ser Leu Gln Leu Gln Glu His Arg Leu 
                85                  90                  95      


Leu His Gly Asp Ala Ala Asn Cys Pro Ser Leu Glu Asn Met Asp Leu 
            100                 105                 110         


Asp Glu Leu Ser Leu Phe Gly Pro Leu Pro Gly Pro Gly Pro Ala Leu 
        115                 120                 125             


Val Asp Arg Asn Arg Leu Ser Ser Glu Ser Ser Cys Lys Ser Trp Leu 
    130                 135                 140                 


Ser Ser Met Thr Met Asp Ser Glu Asp Gly Tyr Gln Thr Cys Val Ser 
145                 150                 155                 160 


Glu Asp Ser Ser Arg Gly Ala Phe Ser Arg Gln Thr Ser Thr Asp Asp 
                165                 170                 175     


Glu Cys Phe Ile Pro Lys Glu Gly Asp Asp Phe Leu Arg Arg Ser Ser 
            180                 185                 190         


Ser Arg Arg Asn Arg Ser Ile Ser Asn Thr Ser Ser Gly Ser Met Ser 
        195                 200                 205             


Pro Leu Trp Glu Gly Asn Leu Ser Ser Met Phe Gly Thr Leu Pro Arg 
    210                 215                 220                 


Lys Ser Arg Lys Gly Ser Val Arg Lys Gln Leu Leu Lys Phe Ile Pro 
225                 230                 235                 240 


Gly Leu His Arg Ala Val Glu Glu Glu Glu Ser Arg Phe 
                245                 250             


<210>  138
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Val Asp Ile 
                805                 810                 815     


Pro Glu Ile His Glu Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu 
            820                 825                 830         


Tyr Glu Val Asp Trp Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly 
        835                 840                 845             


Ala Pro Ser Thr Asp Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro 
    850                 855                 860                 


Ile Leu Ile Thr Ile Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly 
865                 870                 875                 880 


Ala Thr Cys Ala Gly Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly 
                885                 890                 895     


Leu Ser Ser Arg Ser Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu 
            900                 905                 910         


Tyr Asp Gly Leu Lys His Lys Val Lys Met Asn His Gln Lys Cys Cys 
        915                 920                 925             


Ser Glu Ala 
    930     


<210>  139
<211>  909
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Asp Glu Tyr Glu Val Asp Trp Ser 
                805                 810                 815     


Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp Lys 
            820                 825                 830         


Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile Ile 
        835                 840                 845             


Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly Leu 
    850                 855                 860                 


Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser Cys 
865                 870                 875                 880 


Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys His 
                885                 890                 895     


Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
            900                 905                 


<210>  140
<211>  926
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Val Asp Ile Pro Glu Ile His Glu 
                805                 810                 815     


Arg Glu Gly Tyr Glu Asp Glu Ile Asp Asp Glu Tyr Glu Val Asp Trp 
            820                 825                 830         


Ser Asn Ser Ser Ser Ala Thr Ser Gly Ser Gly Ala Pro Ser Thr Asp 
        835                 840                 845             


Lys Glu Lys Ser Trp Leu Tyr Thr Leu Asp Pro Ile Leu Ile Thr Ile 
    850                 855                 860                 


Ile Ala Met Ser Ser Leu Gly Val Leu Leu Gly Ala Thr Cys Ala Gly 
865                 870                 875                 880 


Leu Leu Leu Tyr Cys Thr Cys Ser Tyr Ser Gly Leu Ser Ser Arg Ser 
                885                 890                 895     


Cys Thr Thr Leu Glu Asn Tyr Asn Phe Glu Leu Tyr Asp Gly Leu Lys 
            900                 905                 910         


His Lys Val Lys Met Asn His Gln Lys Cys Cys Ser Glu Ala 
        915                 920                 925     


<210>  141
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Gly Thr Leu Leu Pro Gly Thr 
                805                 810                 815     


Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro Ile Pro Ala Tyr Trp 
            820                 825                 830         


Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu Val Leu Val Ser Val 
        835                 840                 845             


Ala Leu Ala Leu Val Leu His Tyr His Arg Phe Arg Tyr Ala Ala Lys 
    850                 855                 860                 


Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser His Tyr Thr Asn Gly 
865                 870                 875                 880 


Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile Lys Leu Glu Gln Asp 
                885                 890                 895     


Arg Gly Ser His Cys 
            900     


<210>  142
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Leu Phe Glu Gly Asn Met His Tyr Asp Thr Pro Asp Ile 
545                 550                 555                 560 


Arg Arg Phe Asp Pro Ile Pro Ala Gln Tyr Val Arg Val Tyr Pro Glu 
                565                 570                 575     


Arg Trp Ser Pro Ala Gly Ile Gly Met Arg Leu Glu Val Leu Gly Cys 
            580                 585                 590         


Asp Trp Thr Asp Ser Lys Pro Thr Val Glu Thr Leu Gly Pro Thr Val 
        595                 600                 605             


Lys Ser Glu Glu Thr Thr Thr Pro Tyr Pro Thr Glu Glu Glu Ala Thr 
    610                 615                 620                 


Glu Cys Gly Glu Asn Cys Ser Phe Glu Asp Asp Lys Asp Leu Gln Leu 
625                 630                 635                 640 


Pro Ser Gly Phe Asn Cys Asn Phe Asp Phe Leu Glu Glu Pro Cys Gly 
                645                 650                 655     


Trp Met Tyr Asp His Ala Lys Trp Leu Arg Thr Thr Trp Ala Ser Ser 
            660                 665                 670         


Ser Ser Pro Asn Asp Arg Thr Phe Pro Asp Asp Arg Asn Phe Leu Arg 
        675                 680                 685             


Leu Gln Ser Asp Ser Gln Arg Glu Gly Gln Tyr Ala Arg Leu Ile Ser 
    690                 695                 700                 


Pro Pro Val His Leu Pro Arg Ser Pro Val Cys Met Glu Phe Gln Tyr 
705                 710                 715                 720 


Gln Ala Thr Gly Gly Arg Gly Val Ala Leu Gln Val Val Arg Glu Ala 
                725                 730                 735     


Ser Gln Glu Ser Lys Leu Leu Trp Val Ile Arg Glu Asp Gln Gly Gly 
            740                 745                 750         


Glu Trp Lys His Gly Arg Ile Ile Leu Pro Ser Tyr Asp Met Glu Tyr 
        755                 760                 765             


Gln Ile Val Phe Glu Gly Val Ile Gly Lys Gly Arg Ser Gly Glu Ile 
    770                 775                 780                 


Ala Ile Asp Asp Ile Arg Ile Ser Thr Asp Val Pro Leu Glu Asn Cys 
785                 790                 795                 800 


Met Glu Pro Ile Ser Ala Phe Ala Gly Glu Asn Phe Lys Gly Gly Thr 
                805                 810                 815     


Leu Leu Pro Gly Thr Glu Pro Thr Val Asp Thr Val Pro Met Gln Pro 
            820                 825                 830         


Ile Pro Ala Tyr Trp Tyr Tyr Val Met Ala Ala Gly Gly Ala Val Leu 
        835                 840                 845             


Val Leu Val Ser Val Ala Leu Ala Leu Val Leu His Tyr His Arg Phe 
    850                 855                 860                 


Arg Tyr Ala Ala Lys Lys Thr Asp His Ser Ile Thr Tyr Lys Thr Ser 
865                 870                 875                 880 


His Tyr Thr Asn Gly Ala Pro Leu Ala Val Glu Pro Thr Leu Thr Ile 
                885                 890                 895     


Lys Leu Glu Gln Asp Arg Gly Ser His Cys 
            900                 905     


<210>  143
<211>  555
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Asp Met Phe Pro Leu Thr Trp Val Phe Leu Ala Leu Tyr Phe Ser 
1               5                   10                  15      


Arg His Gln Val Arg Gly Gln Pro Asp Pro Pro Cys Gly Gly Arg Leu 
            20                  25                  30          


Asn Ser Lys Asp Ala Gly Tyr Ile Thr Ser Pro Gly Tyr Pro Gln Asp 
        35                  40                  45              


Tyr Pro Ser His Gln Asn Cys Glu Trp Ile Val Tyr Ala Pro Glu Pro 
    50                  55                  60                  


Asn Gln Lys Ile Val Leu Asn Phe Asn Pro His Phe Glu Ile Glu Lys 
65                  70                  75                  80  


His Asp Cys Lys Tyr Asp Phe Ile Glu Ile Arg Asp Gly Asp Ser Glu 
                85                  90                  95      


Ser Ala Asp Leu Leu Gly Lys His Cys Gly Asn Ile Ala Pro Pro Thr 
            100                 105                 110         


Ile Ile Ser Ser Gly Ser Met Leu Tyr Ile Arg Phe Thr Ser Asp Tyr 
        115                 120                 125             


Ala Arg Gln Gly Ala Gly Phe Ser Leu Arg Tyr Glu Ile Phe Lys Thr 
    130                 135                 140                 


Gly Ser Glu Asp Cys Ser Lys Asn Phe Thr Ser Pro Asn Gly Thr Ile 
145                 150                 155                 160 


Glu Ser Pro Gly Phe Pro Glu Lys Tyr Pro His Asn Leu Asp Cys Thr 
                165                 170                 175     


Phe Thr Ile Leu Ala Lys Pro Lys Met Glu Ile Ile Leu Gln Phe Leu 
            180                 185                 190         


Ile Phe Asp Leu Glu His Asp Pro Leu Gln Val Gly Glu Gly Asp Cys 
        195                 200                 205             


Lys Tyr Asp Trp Leu Asp Ile Trp Asp Gly Ile Pro His Val Gly Pro 
    210                 215                 220                 


Leu Ile Gly Lys Tyr Cys Gly Thr Lys Thr Pro Ser Glu Leu Arg Ser 
225                 230                 235                 240 


Ser Thr Gly Ile Leu Ser Leu Thr Phe His Thr Asp Met Ala Val Ala 
                245                 250                 255     


Lys Asp Gly Phe Ser Ala Arg Tyr Tyr Leu Val His Gln Glu Pro Leu 
            260                 265                 270         


Glu Asn Phe Gln Cys Asn Val Pro Leu Gly Met Glu Ser Gly Arg Ile 
        275                 280                 285             


Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg Trp 
    290                 295                 300                 


Thr Pro Gln Gln Ser Arg Leu His Gly Asp Asp Asn Gly Trp Thr Pro 
305                 310                 315                 320 


Asn Leu Asp Ser Asn Lys Glu Tyr Leu Gln Val Asp Leu Arg Phe Leu 
                325                 330                 335     


Thr Met Leu Thr Ala Ile Ala Thr Gln Gly Ala Ile Ser Arg Glu Thr 
            340                 345                 350         


Gln Asn Gly Tyr Tyr Val Lys Ser Tyr Lys Leu Glu Val Ser Thr Asn 
        355                 360                 365             


Gly Glu Asp Trp Met Val Tyr Arg His Gly Lys Asn His Lys Val Phe 
    370                 375                 380                 


Gln Ala Asn Asn Asp Ala Thr Glu Val Val Leu Asn Lys Leu His Ala 
385                 390                 395                 400 


Pro Leu Leu Thr Arg Phe Val Arg Ile Arg Pro Gln Thr Trp His Ser 
                405                 410                 415     


Gly Ile Ala Leu Arg Leu Glu Leu Phe Gly Cys Arg Val Thr Asp Ala 
            420                 425                 430         


Pro Cys Ser Asn Met Leu Gly Met Leu Ser Gly Leu Ile Ala Asp Ser 
        435                 440                 445             


Gln Ile Ser Ala Ser Ser Thr Gln Glu Tyr Leu Trp Ser Pro Ser Ala 
    450                 455                 460                 


Ala Arg Leu Val Ser Ser Arg Ser Gly Trp Phe Pro Arg Ile Pro Gln 
465                 470                 475                 480 


Ala Gln Pro Gly Glu Glu Trp Leu Gln Val Asp Leu Gly Thr Pro Lys 
                485                 490                 495     


Thr Val Lys Gly Val Ile Ile Gln Gly Ala Arg Gly Gly Asp Ser Ile 
            500                 505                 510         


Thr Ala Val Glu Ala Arg Ala Phe Val Arg Lys Phe Lys Val Ser Tyr 
        515                 520                 525             


Ser Leu Asn Gly Lys Asp Trp Glu Tyr Ile Gln Asp Pro Arg Thr Gln 
    530                 535                 540                 


Gln Pro Lys Val Gly Cys Ser Trp Arg Pro Leu 
545                 550                 555 


<210>  144
<211>  666
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Thr Pro Pro Pro Pro Gly Arg Ala Ala Pro Ser Ala Pro Arg Ala 
1               5                   10                  15      


Arg Val Pro Gly Pro Pro Ala Arg Leu Gly Leu Pro Leu Arg Leu Arg 
            20                  25                  30          


Leu Leu Leu Leu Leu Trp Ala Ala Ala Ala Ser Ala Gln Gly His Leu 
        35                  40                  45              


Arg Ser Gly Pro Arg Ile Phe Ala Val Trp Lys Gly His Val Gly Gln 
    50                  55                  60                  


Asp Arg Val Asp Phe Gly Gln Thr Glu Pro His Thr Val Leu Phe His 
65                  70                  75                  80  


Glu Pro Gly Ser Ser Ser Val Trp Val Gly Gly Arg Gly Lys Val Tyr 
                85                  90                  95      


Leu Phe Asp Phe Pro Glu Gly Lys Asn Ala Ser Val Arg Thr Val Asn 
            100                 105                 110         


Ile Gly Ser Thr Lys Gly Ser Cys Leu Asp Lys Arg Asp Cys Glu Asn 
        115                 120                 125             


Tyr Ile Thr Leu Leu Glu Arg Arg Ser Glu Gly Leu Leu Ala Cys Gly 
    130                 135                 140                 


Thr Asn Ala Arg His Pro Ser Cys Trp Asn Leu Val Asn Gly Thr Val 
145                 150                 155                 160 


Val Pro Leu Gly Glu Met Arg Gly Tyr Ala Pro Phe Ser Pro Asp Glu 
                165                 170                 175     


Asn Ser Leu Val Leu Phe Glu Gly Asp Glu Val Tyr Ser Thr Ile Arg 
            180                 185                 190         


Lys Gln Glu Tyr Asn Gly Lys Ile Pro Arg Phe Arg Arg Ile Arg Gly 
        195                 200                 205             


Glu Ser Glu Leu Tyr Thr Ser Asp Thr Val Met Gln Asn Pro Gln Phe 
    210                 215                 220                 


Ile Lys Ala Thr Ile Val His Gln Asp Gln Ala Tyr Asp Asp Lys Ile 
225                 230                 235                 240 


Tyr Tyr Phe Phe Arg Glu Asp Asn Pro Asp Lys Asn Pro Glu Ala Pro 
                245                 250                 255     


Leu Asn Val Ser Arg Val Ala Gln Leu Cys Arg Gly Asp Gln Gly Gly 
            260                 265                 270         


Glu Ser Ser Leu Ser Val Ser Lys Trp Asn Thr Phe Leu Lys Ala Met 
        275                 280                 285             


Leu Val Cys Ser Asp Ala Ala Thr Asn Lys Asn Phe Asn Arg Leu Gln 
    290                 295                 300                 


Asp Val Phe Leu Leu Pro Asp Pro Ser Gly Gln Trp Arg Asp Thr Arg 
305                 310                 315                 320 


Val Tyr Gly Val Phe Ser Asn Pro Trp Asn Tyr Ser Ala Val Cys Val 
                325                 330                 335     


Tyr Ser Leu Gly Asp Ile Asp Lys Val Phe Arg Thr Ser Ser Leu Lys 
            340                 345                 350         


Gly Tyr His Ser Ser Leu Pro Asn Pro Arg Pro Gly Lys Cys Leu Pro 
        355                 360                 365             


Asp Gln Gln Pro Ile Pro Thr Glu Thr Phe Gln Val Ala Asp Arg His 
    370                 375                 380                 


Pro Glu Val Ala Gln Arg Val Glu Pro Met Gly Pro Leu Lys Thr Pro 
385                 390                 395                 400 


Leu Phe His Ser Lys Tyr His Tyr Gln Lys Val Ala Val His Arg Met 
                405                 410                 415     


Gln Ala Ser His Gly Glu Thr Phe His Val Leu Tyr Leu Thr Thr Asp 
            420                 425                 430         


Arg Gly Thr Ile His Lys Val Val Glu Pro Gly Glu Gln Glu His Ser 
        435                 440                 445             


Phe Ala Phe Asn Ile Met Glu Ile Gln Pro Phe Arg Arg Ala Ala Ala 
    450                 455                 460                 


Ile Gln Thr Met Ser Leu Asp Ala Glu Arg Arg Lys Leu Tyr Val Ser 
465                 470                 475                 480 


Ser Gln Trp Glu Val Ser Gln Val Pro Leu Asp Leu Cys Glu Val Tyr 
                485                 490                 495     


Gly Gly Gly Cys His Gly Cys Leu Met Ser Arg Asp Pro Tyr Cys Gly 
            500                 505                 510         


Trp Asp Gln Gly Arg Cys Ile Ser Ile Tyr Ser Ser Glu Arg Ser Val 
        515                 520                 525             


Leu Gln Ser Ile Asn Pro Ala Glu Pro His Lys Glu Cys Pro Asn Pro 
    530                 535                 540                 


Lys Pro Asp Lys Ala Pro Leu Gln Lys Val Ser Leu Ala Pro Asn Ser 
545                 550                 555                 560 


Arg Tyr Tyr Leu Ser Cys Pro Met Glu Ser Arg His Ala Thr Tyr Ser 
                565                 570                 575     


Trp Arg His Lys Glu Asn Val Glu Gln Ser Cys Glu Pro Gly His Gln 
            580                 585                 590         


Ser Pro Asn Cys Ile Leu Phe Ile Glu Asn Leu Thr Ala Gln Gln Tyr 
        595                 600                 605             


Gly His Tyr Phe Cys Glu Ala Gln Glu Gly Ser Tyr Phe Arg Glu Ala 
    610                 615                 620                 


Gln His Trp Gln Leu Leu Pro Glu Asp Gly Ile Met Ala Glu His Leu 
625                 630                 635                 640 


Leu Gly His Ala Cys Ala Leu Ala Ala Ser Leu Trp Leu Gly Val Leu 
                645                 650                 655     


Pro Thr Leu Thr Leu Gly Leu Leu Val His 
            660                 665     


<210>  145
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Thr Pro Pro Pro Pro Gly Arg Ala Ala Pro Ser Ala Pro Arg Ala 
1               5                   10                  15      


Arg Val Pro Gly Pro Pro Ala Arg Leu Gly Leu Pro Leu Arg Leu Arg 
            20                  25                  30          


Leu Leu Leu Leu Leu Trp Ala Ala Ala Ala Ser Ala Gln Gly His Leu 
        35                  40                  45              


Arg Ser Gly Pro Arg Ile Phe Ala Val Trp Lys Gly His Val Gly Gln 
    50                  55                  60                  


Asp Arg Val Asp Phe Gly Gln Thr Glu Pro His Thr Val Leu Phe His 
65                  70                  75                  80  


Glu Pro Gly Ser Ser Ser Val Trp Val Gly Gly Arg Gly Lys Val Tyr 
                85                  90                  95      


Leu Phe Asp Phe Pro Glu Gly Lys Asn Ala Ser Val Arg Thr Asp Cys 
            100                 105                 110         


Glu Asn Tyr Ile Thr Leu Leu Glu Arg Arg Ser Glu Gly Leu Leu Ala 
        115                 120                 125             


Cys Gly Thr Asn Ala Arg His Pro Ser Cys Trp Asn Leu Val Asn Gly 
    130                 135                 140                 


Thr Val Val Pro Leu Gly Glu Met Arg Gly Tyr Ala Pro Phe Ser Pro 
145                 150                 155                 160 


Asp Glu Asn Ser Leu Val Leu Phe Glu Gly Asp Glu Val Tyr Ser Thr 
                165                 170                 175     


Ile Arg Lys Gln Glu Tyr Asn Gly Lys Ile Pro Arg Phe Arg Arg Ile 
            180                 185                 190         


Arg Gly Glu Ser Glu Leu Tyr Thr Ser Asp Thr Val Met Gln Asn Pro 
        195                 200                 205             


Gln Phe Ile Lys Ala Thr Ile Val His Gln Asp Gln Ala Tyr Asp Asp 
    210                 215                 220                 


Lys Ile Tyr Tyr Phe Phe Arg Glu Asp Asn Pro Asp Lys Asn Pro Glu 
225                 230                 235                 240 


Ala Pro Leu Asn Val Ser Arg Val Ala Gln Leu Cys Arg Gly Asp Gln 
                245                 250                 255     


Gly Gly Glu Ser Ser Leu Ser Val Ser Lys Trp Asn Thr Phe Leu Lys 
            260                 265                 270         


Ala Met Leu Val Cys Ser Asp Ala Ala Thr Asn Lys Asn Phe Asn Arg 
        275                 280                 285             


Leu Gln Asp Val Phe Leu Leu Pro Asp Pro Ser Gly Gln Trp Arg Asp 
    290                 295                 300                 


Thr Arg Val Tyr Gly Val Phe Ser Asn Pro Trp Asn Tyr Ser Ala Val 
305                 310                 315                 320 


Cys Val Tyr Ser Leu Gly Asp Ile Asp Lys Val Phe Arg Thr Ser Ser 
                325                 330                 335     


Leu Lys Gly Tyr His Ser Ser Leu Pro Asn Pro Arg Pro Gly Lys Cys 
            340                 345                 350         


Leu Pro Asp Gln Gln Pro Ile Pro Thr Glu Thr Phe Gln Val Ala Asp 
        355                 360                 365             


Arg His Pro Glu Val Ala Gln Arg Val Glu Pro Met Gly Pro Leu Lys 
    370                 375                 380                 


Thr Pro Leu Phe His Ser Lys Tyr His Tyr Gln Lys Val Ala Val His 
385                 390                 395                 400 


Arg Met Gln Ala Ser His Gly Glu Thr Phe His Val Leu Tyr Leu Thr 
                405                 410                 415     


Thr Asp Arg Gly Thr Ile His Lys Val Val Glu Pro Gly Glu Gln Glu 
            420                 425                 430         


His Ser Phe Ala Phe Asn Ile Met Glu Ile Gln Pro Phe Arg Arg Ala 
        435                 440                 445             


Ala Ala Ile Gln Thr Met Ser Leu Asp Ala Glu Arg Arg Lys Leu Tyr 
    450                 455                 460                 


Val Ser Ser Gln Trp Glu Val Ser Gln Val Pro Leu Asp Leu Cys Glu 
465                 470                 475                 480 


Val Tyr Gly Gly Gly Cys His Gly Cys Leu Met Ser Arg Asp Pro Tyr 
                485                 490                 495     


Cys Gly Trp Asp Gln Gly Arg Cys Ile Ser Ile Tyr Ser Ser Glu Arg 
            500                 505                 510         


Ser Val Leu Gln Ser Ile Asn Pro Ala Glu Pro His Lys Glu Cys Pro 
        515                 520                 525             


Asn Pro Lys Pro Asp Lys Ala Pro Leu Gln Lys Val Ser Leu Ala Pro 
    530                 535                 540                 


Asn Ser Arg Tyr Tyr Leu Ser Cys Pro Met Glu Ser Arg His Ala Thr 
545                 550                 555                 560 


Tyr Ser Trp Arg His Lys Glu Asn Val Glu Gln Ser Cys Glu Pro Gly 
                565                 570                 575     


His Gln Ser Pro Asn Cys Ile Leu Phe Ile Glu Asn Leu Thr Ala Gln 
            580                 585                 590         


Gln Tyr Gly His Tyr Phe Cys Glu Ala Gln Glu Gly Ser Tyr Phe Arg 
        595                 600                 605             


Glu Ala Gln His Trp Gln Leu Leu Pro Glu Asp Gly Ile Met Ala Glu 
    610                 615                 620                 


His Leu Leu Gly His Ala Cys Ala Leu Ala Ala Ser Leu Trp Leu Gly 
625                 630                 635                 640 


Val Leu Pro Thr Leu Thr Leu Gly Leu Leu Val His 
                645                 650         


<210>  146
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Ser Ser Leu His Lys Ser Arg Ile Ala Asp Phe Gln Asp Val Leu 
1               5                   10                  15      


Lys Glu Pro Ser Ile Ala Leu Glu Lys Leu Arg Glu Leu Ser Phe Ser 
            20                  25                  30          


Gly Ile Pro Cys Glu Gly Gly Leu Arg Cys Leu Cys Trp Lys Ile Leu 
        35                  40                  45              


Leu Asn Tyr Leu Pro Leu Glu Arg Ala Ser Trp Thr Ser Ile Leu Ala 
    50                  55                  60                  


Lys Gln Arg Glu Leu Tyr Ala Gln Phe Leu Arg Glu Met Ile Ile Gln 
65                  70                  75                  80  


Pro Gly Ile Ala Lys Ala Asn Met Gly Val Ser Arg Glu Asp Val Thr 
                85                  90                  95      


Phe Glu Asp His Pro Leu Asn Pro Asn Pro Asp Ser Arg Trp Asn Thr 
            100                 105                 110         


Tyr Phe Lys Asp Asn Glu Val Leu Leu Gln Ile Asp Lys Asp Val Arg 
        115                 120                 125             


Arg Leu Cys Pro Asp Ile Ser Phe Phe Gln Arg Ala Thr Asp Tyr Pro 
    130                 135                 140                 


Cys Leu Leu Ile Leu Asp Pro Gln Asn Glu Phe Glu Thr Leu Arg Lys 
145                 150                 155                 160 


Arg Val Glu Gln Thr Thr Leu Lys Ser Gln Thr Val Ala Arg Asn Arg 
                165                 170                 175     


Ser Gly Val Thr Asn Met Ser Ser Pro His Lys Asn Ser Val Pro Ser 
            180                 185                 190         


Ser Leu Asn Glu Tyr Glu Val Leu Pro Asn Gly Cys Glu Ala His Trp 
        195                 200                 205             


Glu Val Val Glu Arg Ile Leu Phe Ile Tyr Ala Lys Leu Asn Pro Gly 
    210                 215                 220                 


Ile Ala Tyr Val Gln Gly Met Asn Glu Ile Val Gly Pro Leu Tyr Tyr 
225                 230                 235                 240 


Thr Phe Ala Thr Asp Pro Asn Ser Glu Trp Lys Glu His Ala Glu Ala 
                245                 250                 255     


Asp Thr Phe Phe Cys Phe Thr Asn Leu Met Ala Glu Ile Arg Asp Asn 
            260                 265                 270         


Phe Ile Lys Ser Leu Asp Asp Ser Gln Cys Gly Ile Thr Tyr Lys Met 
        275                 280                 285             


Glu Lys Val Tyr Ser Thr Leu Lys Asp Lys Asp Val Glu Leu Tyr Leu 
    290                 295                 300                 


Lys Leu Gln Glu Gln Asn Ile Lys Pro Gln Phe Phe Ala Phe Arg Trp 
305                 310                 315                 320 


Leu Thr Leu Leu Leu Ser Gln Glu Phe Leu Leu Pro Asp Val Ile Arg 
                325                 330                 335     


Ile Trp Asp Ser Leu Phe Ala Asp Asp Asn Arg Phe Asp Phe Leu Leu 
            340                 345                 350         


Leu Val Cys Cys Ala Met Leu Met Leu Ile Arg Glu Gln Leu Leu Glu 
        355                 360                 365             


Gly Asp Phe Thr Val Asn Met Arg Leu Leu Gln Asp Tyr Pro Ile Thr 
    370                 375                 380                 


Asp Val Cys Gln Ile Leu Gln Lys Ala Lys Glu Leu Gln Asp Ser Lys 
385                 390                 395                 400 


<210>  147
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ser Ser Leu His Lys Ser Arg Ile Ala Asp Phe Gln Asp Val Leu 
1               5                   10                  15      


Lys Glu Pro Ser Ile Ala Leu Glu Lys Leu Arg Glu Leu Ser Phe Ser 
            20                  25                  30          


Gly Ile Pro Cys Glu Gly Gly Leu Arg Cys Leu Cys Trp Lys Ile Leu 
        35                  40                  45              


Leu Asn Tyr Leu Pro Leu Glu Arg Ala Ser Trp Thr Ser Ile Leu Ala 
    50                  55                  60                  


Lys Gln Arg Glu Leu Tyr Ala Gln Phe Leu Arg Glu Met Ile Ile Gln 
65                  70                  75                  80  


Pro Gly Ile Ala Lys Ala Asn Met Gly Val Ser Arg Glu Asp Val Thr 
                85                  90                  95      


Phe Glu Asp His Pro Leu Asn Pro Asn Pro Asp Ser Arg Trp Asn Thr 
            100                 105                 110         


Tyr Phe Lys Asp Asn Glu Val Leu Leu Gln Ile Asp Lys Asp Val Arg 
        115                 120                 125             


Arg Leu Cys Pro Asp Ile Ser Phe Phe Gln Arg Ala Thr Asp Tyr Pro 
    130                 135                 140                 


Cys Leu Leu Ile Leu Asp Pro Gln Asn Glu Phe Glu Thr Leu Arg Lys 
145                 150                 155                 160 


Arg Val Glu Gln Thr Thr Leu Lys Ser Gln Thr Val Ala Arg Asn Arg 
                165                 170                 175     


Ser Gly Val Thr Asn Gln Glu Gln Asn Ile Lys Pro Gln Phe Phe Ala 
            180                 185                 190         


Phe Arg Trp Leu Thr Leu Leu Leu Ser Gln Glu Phe Leu Leu Pro Asp 
        195                 200                 205             


Val Ile Arg Ile Trp Asp Ser Leu Phe Ala Asp Asp Asn Arg Phe Asp 
    210                 215                 220                 


Phe Leu Leu Leu Val Cys Cys Ala Met Leu Met Leu Ile Arg Glu Gln 
225                 230                 235                 240 


Leu Leu Glu Gly Asp Phe Thr Val Asn Met Arg Leu Leu Gln Asp Tyr 
                245                 250                 255     


Pro Ile Thr Asp Val Cys Gln Ile Leu Gln Lys Ala Lys Glu Leu Gln 
            260                 265                 270         


Asp Ser Lys 
        275 


<210>  148
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ser Ser Pro His Lys Asn Ser Val Pro Ser Ser Leu Asn Glu Tyr 
1               5                   10                  15      


Glu Val Leu Pro Asn Gly Cys Glu Ala His Trp Glu Val Val Glu Arg 
            20                  25                  30          


Ile Leu Phe Ile Tyr Ala Lys Leu Asn Pro Gly Ile Ala Tyr Val Gln 
        35                  40                  45              


Gly Met Asn Glu Ile Val Gly Pro Leu Tyr Tyr Thr Phe Ala Thr Asp 
    50                  55                  60                  


Pro Asn Ser Glu Trp Lys Glu His Ala Glu Ala Asp Thr Phe Phe Cys 
65                  70                  75                  80  


Phe Thr Asn Leu Met Ala Glu Ile Arg Asp Asn Phe Ile Lys Ser Leu 
                85                  90                  95      


Asp Asp Ser Gln Cys Gly Ile Thr Tyr Lys Met Glu Lys Val Tyr Ser 
            100                 105                 110         


Thr Leu Lys Asp Lys Asp Val Glu Leu Tyr Leu Lys Leu Gln Glu Gln 
        115                 120                 125             


Asn Ile Lys Pro Gln Phe Phe Ala Phe Arg Trp Leu Thr Leu Leu Leu 
    130                 135                 140                 


Ser Gln Glu Phe Leu Leu Pro Asp Val Ile Arg Ile Trp Asp Ser Leu 
145                 150                 155                 160 


Phe Ala Asp Asp Asn Arg Phe Asp Phe Leu Leu Leu Val Cys Cys Ala 
                165                 170                 175     


Met Leu Met Leu Ile Arg Glu Gln Leu Leu Glu Gly Asp Phe Thr Val 
            180                 185                 190         


Asn Met Arg Leu Leu Gln Asp Tyr Pro Ile Thr Asp Val Cys Gln Ile 
        195                 200                 205             


Leu Gln Lys Ala Lys Glu Leu Gln Asp Ser Lys 
    210                 215                 


<210>  149
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  150
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  151
<211>  575
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Leu Gly Val Leu Val Leu Gly Ala Leu Ala Leu Ala Gly Leu Gly 
1               5                   10                  15      


Phe Pro Ala Pro Ala Glu Pro Gln Pro Gly Gly Ser Gln Cys Val Glu 
            20                  25                  30          


His Asp Cys Phe Ala Leu Tyr Pro Gly Pro Ala Thr Phe Leu Asn Ala 
        35                  40                  45              


Ser Gln Ile Cys Asp Gly Leu Arg Gly His Leu Met Thr Val Arg Ser 
    50                  55                  60                  


Ser Val Ala Ala Asp Val Ile Ser Leu Leu Leu Asn Gly Asp Gly Gly 
65                  70                  75                  80  


Val Gly Arg Arg Arg Leu Trp Ile Gly Leu Gln Leu Pro Pro Gly Cys 
                85                  90                  95      


Gly Asp Pro Lys Arg Leu Gly Pro Leu Arg Gly Phe Gln Trp Val Thr 
            100                 105                 110         


Gly Asp Asn Asn Thr Ser Tyr Ser Arg Trp Ala Arg Leu Asp Leu Asn 
        115                 120                 125             


Gly Ala Pro Leu Cys Gly Pro Leu Cys Val Ala Val Ser Ala Ala Glu 
    130                 135                 140                 


Ala Thr Val Pro Ser Glu Pro Ile Trp Glu Glu Gln Gln Cys Glu Val 
145                 150                 155                 160 


Lys Ala Asp Gly Phe Leu Cys Glu Phe His Phe Pro Ala Thr Cys Arg 
                165                 170                 175     


Pro Leu Ala Val Glu Pro Gly Ala Ala Ala Ala Ala Val Ser Ile Thr 
            180                 185                 190         


Tyr Gly Thr Pro Phe Ala Ala Arg Gly Ala Asp Phe Gln Ala Leu Pro 
        195                 200                 205             


Val Gly Ser Ser Ala Ala Val Ala Pro Leu Gly Leu Gln Leu Met Cys 
    210                 215                 220                 


Thr Ala Pro Pro Gly Ala Val Gln Gly His Trp Ala Arg Glu Ala Pro 
225                 230                 235                 240 


Gly Ala Trp Asp Cys Ser Val Glu Asn Gly Gly Cys Glu His Ala Cys 
                245                 250                 255     


Asn Ala Ile Pro Gly Ala Pro Arg Cys Gln Cys Pro Ala Gly Ala Ala 
            260                 265                 270         


Leu Gln Ala Asp Gly Arg Ser Cys Thr Ala Ser Ala Thr Gln Ser Cys 
        275                 280                 285             


Asn Asp Leu Cys Glu His Phe Cys Val Pro Asn Pro Asp Gln Pro Gly 
    290                 295                 300                 


Ser Tyr Ser Cys Met Cys Glu Thr Gly Tyr Arg Leu Ala Ala Asp Gln 
305                 310                 315                 320 


His Arg Cys Glu Asp Val Asp Asp Cys Ile Leu Glu Pro Ser Pro Cys 
                325                 330                 335     


Pro Gln Arg Cys Val Asn Thr Gln Gly Gly Phe Glu Cys His Cys Tyr 
            340                 345                 350         


Pro Asn Tyr Asp Leu Val Asp Gly Glu Cys Val Glu Pro Val Asp Pro 
        355                 360                 365             


Cys Phe Arg Ala Asn Cys Glu Tyr Gln Cys Gln Pro Leu Asn Gln Thr 
    370                 375                 380                 


Ser Tyr Leu Cys Val Cys Ala Glu Gly Phe Ala Pro Ile Pro His Glu 
385                 390                 395                 400 


Pro His Arg Cys Gln Met Phe Cys Asn Gln Thr Ala Cys Pro Ala Asp 
                405                 410                 415     


Cys Asp Pro Asn Thr Gln Ala Ser Cys Glu Cys Pro Glu Gly Tyr Ile 
            420                 425                 430         


Leu Asp Asp Gly Phe Ile Cys Thr Asp Ile Asp Glu Cys Glu Asn Gly 
        435                 440                 445             


Gly Phe Cys Ser Gly Val Cys His Asn Leu Pro Gly Thr Phe Glu Cys 
    450                 455                 460                 


Ile Cys Gly Pro Asp Ser Ala Leu Ala Arg His Ile Gly Thr Asp Cys 
465                 470                 475                 480 


Asp Ser Gly Lys Val Asp Gly Gly Asp Ser Gly Ser Gly Glu Pro Pro 
                485                 490                 495     


Pro Ser Pro Thr Pro Gly Ser Thr Leu Thr Pro Pro Ala Val Gly Leu 
            500                 505                 510         


Val His Ser Gly Leu Leu Ile Gly Ile Ser Ile Ala Ser Leu Cys Leu 
        515                 520                 525             


Val Val Ala Leu Leu Ala Leu Leu Cys His Leu Arg Lys Lys Gln Gly 
    530                 535                 540                 


Ala Ala Arg Ala Lys Met Glu Tyr Lys Cys Ala Ala Pro Ser Lys Glu 
545                 550                 555                 560 


Val Val Leu Gln His Val Arg Thr Glu Arg Thr Pro Gln Arg Leu 
                565                 570                 575 


<210>  152
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Met Met Lys Ile Pro Trp Gly Ser Ile Pro Val Leu Met Leu Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Ile Asp Ile Ser Gln Ala Gln Leu Ser Cys Thr 
            20                  25                  30          


Gly Pro Pro Ala Ile Pro Gly Ile Pro Gly Ile Pro Gly Thr Pro Gly 
        35                  40                  45              


Pro Asp Gly Gln Pro Gly Thr Pro Gly Ile Lys Gly Glu Lys Gly Leu 
    50                  55                  60                  


Pro Gly Leu Ala Gly Asp His Gly Glu Phe Gly Glu Lys Gly Asp Pro 
65                  70                  75                  80  


Gly Ile Pro Gly Asn Pro Gly Lys Val Gly Pro Lys Gly Pro Met Gly 
                85                  90                  95      


Pro Lys Gly Gly Pro Gly Ala Pro Gly Ala Pro Gly Pro Lys Gly Glu 
            100                 105                 110         


Ser Gly Asp Tyr Lys Ala Thr Gln Lys Ile Ala Phe Ser Ala Thr Arg 
        115                 120                 125             


Thr Ile Asn Val Pro Leu Arg Arg Asp Gln Thr Ile Arg Phe Asp His 
    130                 135                 140                 


Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg Ser Gly Lys Phe 
145                 150                 155                 160 


Thr Cys Lys Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser 
                165                 170                 175     


Arg Gly Asn Leu Cys Val Asn Leu Met Arg Gly Arg Glu Arg Ala Gln 
            180                 185                 190         


Lys Val Val Thr Phe Cys Asp Tyr Ala Tyr Asn Thr Phe Gln Val Thr 
        195                 200                 205             


Thr Gly Gly Met Val Leu Lys Leu Glu Gln Gly Glu Asn Val Phe Leu 
    210                 215                 220                 


Gln Ala Thr Asp Lys Asn Ser Leu Leu Gly Met Glu Gly Ala Asn Ser 
225                 230                 235                 240 


Ile Phe Ser Gly Phe Leu Leu Phe Pro Asp Met Glu Ala 
                245                 250             


<210>  153
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Asp Val Gly Pro Ser Ser Leu Pro His Leu Gly Leu Lys Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Pro Leu Arg Gly Gln Ala Asn Thr Gly Cys 
            20                  25                  30          


Tyr Gly Ile Pro Gly Met Pro Gly Leu Pro Gly Ala Pro Gly Lys Asp 
        35                  40                  45              


Gly Tyr Asp Gly Leu Pro Gly Pro Lys Gly Glu Pro Gly Ile Pro Ala 
    50                  55                  60                  


Ile Pro Gly Ile Arg Gly Pro Lys Gly Gln Lys Gly Glu Pro Gly Leu 
65                  70                  75                  80  


Pro Gly His Pro Gly Lys Asn Gly Pro Met Gly Pro Pro Gly Met Pro 
                85                  90                  95      


Gly Val Pro Gly Pro Met Gly Ile Pro Gly Glu Pro Gly Glu Glu Gly 
            100                 105                 110         


Arg Tyr Lys Gln Lys Phe Gln Ser Val Phe Thr Val Thr Arg Gln Thr 
        115                 120                 125             


His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg Phe Asn Ala Val Leu 
    130                 135                 140                 


Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr Gly Lys Phe Thr Cys 
145                 150                 155                 160 


Lys Val Pro Gly Leu Tyr Tyr Phe Val Tyr His Ala Ser His Thr Ala 
                165                 170                 175     


Asn Leu Cys Val Leu Leu Tyr Arg Ser Gly Val Lys Val Val Thr Phe 
            180                 185                 190         


Cys Gly His Thr Ser Lys Thr Asn Gln Val Asn Ser Gly Gly Val Leu 
        195                 200                 205             


Leu Arg Leu Gln Val Gly Glu Glu Val Trp Leu Ala Val Asn Asp Tyr 
    210                 215                 220                 


Tyr Asp Met Val Gly Ile Gln Gly Ser Asp Ser Val Phe Ser Gly Phe 
225                 230                 235                 240 


Leu Leu Phe Pro Asp 
                245 


<210>  154
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  154

Gln Val Ile Lys Pro Thr Phe Ala Pro Pro Val Pro Pro Val Lys Pro 
1               5                   10                  15      


Gly Ala Gly Ala Ala Asn Pro Gly Pro Ala Glu Gly Ala Val Gly Pro 
            20                  25                  30          


Lys 
    


<210>  155
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  155

Ala Ile Cys Ile Val Asp Val Cys His Ala Leu Thr Thr Glu Asp Gly 
1               5                   10                  15      


Thr Ala Tyr Glu Pro Val Pro Glu Gly Thr Arg 
            20                  25          


<210>  156
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  156

Arg Pro Pro Pro Ala Pro Pro Val Thr Val Ser Ser Pro Pro Phe Pro 
1               5                   10                  15      


Val Pro Val Tyr Thr Arg 
            20          


<210>  157
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  157

Thr Ala Ala Val Phe Arg Pro Arg Pro Gly Asp Ser Leu Pro Ser Arg 
1               5                   10                  15      


<210>  158
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  158

Gln Val Val Asp Leu Ile Arg 
1               5           


<210>  159
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  159

Ile Gln Met Leu Ala Asp Thr Val Ala Thr Leu Pro Arg 
1               5                   10              


<210>  160
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  160

Ile Gln Glu Asp Ser Pro Ala His Cys Ala Gly Leu Gln Ala Gly Asp 
1               5                   10                  15      


Val Leu Ala Asn Ile Asn Gly Val Ser Thr Glu Gly Phe Thr Tyr Lys 
            20                  25                  30          


<210>  161
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  161

Tyr Tyr Leu Val His Gln Glu Pro Leu Glu Asn Phe Gln Cys Asn Val 
1               5                   10                  15      


Pro Leu Gly Met Glu Ser Gly Arg 
            20                  


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  162

Ser Gly Glu Ile Ala Ile Asp Asp Ile Arg 
1               5                   10  


<210>  163
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  163

Ile Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg 
1               5                   10                  15      


Trp Thr Pro Gln Gln Ser Arg 
            20              


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  164

Leu Ile Ser Pro Pro Val His Leu Pro Arg 
1               5                   10  


<210>  165
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  165

Ile Ala Asn Glu Gln Ile Ser Ala Ser Ser Thr Tyr Ser Asp Gly Arg 
1               5                   10                  15      


<210>  166
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  166

Ile Arg Pro Gln Thr Trp His Ser Gly Ile Ala Leu Arg 
1               5                   10              


<210>  167
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  167

Ile Arg Gly Glu Ser Glu Leu Tyr Thr Ser Asp Thr Val Met Gln Asn 
1               5                   10                  15      


Pro Gln Phe Ile Lys 
            20      


<210>  168
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  168

Val Val Glu Pro Gly Glu Gln Glu His Ser Phe Ala Phe Asn Ile Met 
1               5                   10                  15      


Glu Ile Gln Pro Phe Arg Arg 
            20              


<210>  169
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  169

Trp Asn Thr Phe Leu Lys 
1               5       


<210>  170
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  170

Ser Val Leu Gln Ser Ile Asn Pro Ala Glu Pro His Lys Glu Cys Pro 
1               5                   10                  15      


Asn Pro Lys Pro Asp Lys 
            20          


<210>  171
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  171

Ile Phe Ala Val Trp Lys 
1               5       


<210>  172
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  172

Ala Ala Ala Ile Gln Thr Met Ser Leu Asp Ala Glu Arg 
1               5                   10              


<210>  173
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  173

Gly His Val Gly Gln Asp Arg Val Asp Phe Gly Gln Thr Glu Pro His 
1               5                   10                  15      


Thr Val Leu Phe His Glu Pro Gly Ser Ser Ser Val Trp Val Gly Gly 
            20                  25                  30          


Arg 
    


<210>  174
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  174

Asp Cys Glu Asn Tyr Ile Thr Leu Leu Glu Arg 
1               5                   10      


<210>  175
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  175

Met Gln Ala Ser His Gly Glu Thr Phe His Val Leu Tyr Leu Thr Thr 
1               5                   10                  15      


Asp Arg 
        


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  176

Ile Leu Leu Asn Tyr Leu Pro Leu Glu Arg 
1               5                   10  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  177

Glu Met Ile Ile Gln Pro Gly Ile Ala Lys 
1               5                   10  


<210>  178
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  178

Ala Ser Trp Thr Ser Ile Leu Ala Lys 
1               5                   


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  179

Gln Arg Glu Leu Tyr Ala Gln Phe Leu Arg 
1               5                   10  


<210>  180
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  180

Ile Leu Phe Ile Tyr Ala Lys 
1               5           


<210>  181
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  181

Ser Leu Asp Asp Ser Gln Cys Gly Ile Thr Tyr Lys 
1               5                   10          


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  182

Phe Gln Ser Val Phe Thr Val Thr Arg 
1               5                   


<210>  183
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  183

Gln Thr His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg 
1               5                   10              


<210>  184
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  184

Thr Asn Gln Val Asn Ser Gly Gly Val Leu Leu Arg 
1               5                   10          


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  185

Phe Asn Ala Val Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr 
1               5                   10                  15      


Gly Lys 
        


<210>  186
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  186

Phe Asn Ala Val Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr 
1               5                   10                  15      


Gly Lys Phe Thr Cys Lys 
            20          


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  187

Asp Gln Pro Arg Pro Ala Phe Ser Ala Ile Arg 
1               5                   10      


<210>  188
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  188

Val Gly Tyr Pro Gly Pro Ser Gly Pro Leu Gly Ala Arg 
1               5                   10              


<210>  189
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  189

Lys Gly His Ile Tyr Gln Gly Ser Glu Ala Asp Ser Val Phe Ser Gly 
1               5                   10                  15      


Phe Leu Ile Phe Pro Ser Ala 
            20              


<210>  190
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  190

Gly Ser Pro Gly Asn Ile Lys Asp Gln Pro Arg Pro Ala Phe Ser Ala 
1               5                   10                  15      


Ile Arg 
        


<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  191

Gly Asn Leu Cys Val Asn Leu Met Arg 
1               5                   


<210>  192
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  192

Val Pro Gly Leu Tyr Tyr Phe Thr Tyr His Ala Ser Ser Arg 
1               5                   10                  


<210>  193
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  193

Asp Gln Thr Ile Arg Phe Asp His Val Ile Thr Asn Met Asn Asn Asn 
1               5                   10                  15      


Tyr Glu Pro Arg 
            20  


<210>  194
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  194

Phe Asp His Val Ile Thr Asn Met Asn Asn Asn Tyr Glu Pro Arg 
1               5                   10                  15  


<210>  195
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  195

Phe Gln Ser Val Phe Thr Val Thr Arg 
1               5                   


<210>  196
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  196

Gln Thr His Gln Pro Pro Ala Pro Asn Ser Leu Ile Arg 
1               5                   10              


<210>  197
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  197

Thr Asn Gln Val Asn Ser Gly Gly Val Leu Leu Arg 
1               5                   10          


<210>  198
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  198

Phe Asn Ala Val Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr 
1               5                   10                  15      


Gly Lys 
        


<210>  199
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  199

Phe Asn Ala Val Leu Thr Asn Pro Gln Gly Asp Tyr Asp Thr Ser Thr 
1               5                   10                  15      


Gly Lys Phe Thr Cys Lys 
            20          


<210>  200
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  200

Asn Phe Ser Asn Phe Ile Leu Asp Lys 
1               5                   


<210>  201
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  201

Thr Val Gly Ala Gly Ser Leu Val Asp Val Met Pro Trp Leu Gln Tyr 
1               5                   10                  15      


Phe Pro Asn Pro Val Arg 
            20          


<210>  202
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  202

Asp Leu Phe Gln Val Ile Tyr Asn Val Lys 
1               5                   10  


<210>  203
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  203

Ala Phe Gly Tyr Val Cys Gly Gly Glu Gly Gln His Gln Phe Phe Ala 
1               5                   10                  15      


Ile Lys 
        


<210>  204
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  204

Thr Gly Gln Gln Ala Glu Pro Leu Val Val Asp Leu Lys 
1               5                   10              


<210>  205
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  205

Leu Ile Gly Ile Asp Asp Val Pro Asp Ala Arg 
1               5                   10      


<210>  206
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  206

Ser Thr Asp Asn Ala Phe Glu Asn Pro Phe Phe Lys 
1               5                   10          


<210>  207
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  207

Ser Phe Ile Thr Ser Ile Ala Asn Lys 
1               5                   


<210>  208
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  208

Ser Leu Ser Val Asn Glu Met Thr Leu Ser Thr Leu Lys 
1               5                   10              


<210>  209
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  209

Arg Thr Thr Tyr Gly Gly Val Ser Gly Thr Ala Ile Arg Pro Ile Ala 
1               5                   10                  15      


Leu Arg 
        


<210>  210
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  210

Asp Ala Ile Phe Gln Gly Leu Thr Gln Asp Gln Gly Phe Tyr Thr Ser 
1               5                   10                  15      


Lys Asp Phe Leu Pro Leu Val Ala Lys 
            20                  25  


<210>  211
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  211

Ser Ile Glu Glu Leu Gln Asp Trp Asp Gly Gln Ser Pro Ala Thr Val 
1               5                   10                  15      


Ser His Gln Lys 
            20  


<210>  212
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  212

Ala Gly Met Cys Ala Cys His Ser Pro Leu Pro Ser Ile Arg 
1               5                   10                  


<210>  213
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  213

Asp Phe Leu Pro Leu Val Ala Lys 
1               5               


<210>  214
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  214

Arg Gln Leu Glu Glu Thr Asn Asn Asp Tyr Glu Thr Ala Asp Gly Gly 
1               5                   10                  15      


Tyr Met Thr Leu Asn Pro Arg 
            20              


<210>  215
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  215

Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile 
1               5                   10                  15      


Pro Thr His Thr Gln Pro Ser Tyr Arg 
            20                  25  


<210>  216
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  216

Val Gly Ala Glu Asn Thr Ile Thr Tyr Ser Leu Leu Met His Pro Asp 
1               5                   10                  15      


Ala Leu Glu Glu Pro Asp Asp Gln Asn Arg Ile 
            20                  25          


<210>  217
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  217

Ala Val Leu Lys Leu Glu Pro Gln Trp Ile Asn Val Leu Gln Glu Asp 
1               5                   10                  15      


Ser Val Thr Leu Thr Cys Arg 
            20              


<210>  218
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  218

Glu Met Gly Glu Thr Leu Pro Glu Lys Pro Ala Asn Pro Thr Asn Pro 
1               5                   10                  15      


Asp Glu Ala Asp Lys 
            20      


<210>  219
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  219

Gly Thr His Ser Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly 
1               5                   10                  15      


Asn Leu Ile Pro Thr His Thr Gln Pro Ser Tyr Arg 
            20                  25              


<210>  220
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  220

Lys Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
1               5                   10                  15      


<210>  221
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  221

Thr Asp Pro His Leu Cys Asp Phe Leu Glu Thr His Phe Leu Asp Glu 
1               5                   10                  15      


Glu Val Lys 
            


<210>  222
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  222

Ala Leu Phe Gln Asp Ile Lys 
1               5           


<210>  223
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  223

Leu Gly Gly Pro Glu Ala Gly Leu Gly Glu Tyr Leu Phe Glu Arg 
1               5                   10                  15  


<210>  224
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  224

Leu Asn Gln Ala Leu Leu Asp Leu His Ala Leu Gly Ser Ala Arg 
1               5                   10                  15  


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  225

Val Val Ile Asn Val Pro Ile Phe Lys 
1               5                   


<210>  226
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  226

Ile His Leu Asp Asp Ala Asn Glu Ser Asp His Phe Glu Asn Ile Gln 
1               5                   10                  15      


Ser Thr Asn Trp Gln Thr Met Arg 
            20                  


<210>  227
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  227

Val Val Ile Asn Val Pro Ile Phe Lys Asp Lys 
1               5                   10      


<210>  228
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  228

Asn Thr Pro Ser Pro Phe Ile Glu Thr Phe Thr Glu Asp Asp Glu Ala 
1               5                   10                  15      


Ser Arg 
        


<210>  229
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  229

His Gly Ile Leu Gln Phe Leu His Ile Tyr His Ala Val Lys 
1               5                   10                  


<210>  230
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  230

Leu Glu Val Leu Asn Val Leu Arg 
1               5               


<210>  231
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  231

Glu Leu Pro Val Thr Phe Phe Ala His Leu Gln Lys 
1               5                   10          


<210>  232
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  232

Leu Ile Ala Ala Gly Gly Tyr Asn Arg Glu Glu Cys Leu Arg 
1               5                   10                  


<210>  233
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  233

Leu Gln Val Cys Gly His Glu Met Leu Ala His Arg 
1               5                   10          


<210>  234
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  234

Asp Gly Val Gly Gly Leu Pro Thr Phe Leu Glu Asn Ser Phe Ile Gly 
1               5                   10                  15      


Ser Ala Arg 
            


<210>  235
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  235

Asp His Gly Leu Glu Val Leu Gly Leu Val Arg 
1               5                   10      


<210>  236
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  236

Glu Gln Leu Leu Glu Ala Leu Gln Asp Leu Gly Leu Leu Gln Ser Gly 
1               5                   10                  15      


Ser Ile Ser Gly Leu Lys 
            20          


<210>  237
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  237

Val Pro Leu Tyr Thr Leu Arg 
1               5           


<210>  238
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  238

Arg Leu Glu Leu Gly Glu Ala Leu Ala Leu Gly Ser Gly Trp Arg 
1               5                   10                  15  


<210>  239
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  239

Arg Leu Thr Leu Glu Glu Leu Leu Ala Val Glu Ala Gly Ala Thr Arg 
1               5                   10                  15      


<210>  240
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  240

Ile Tyr Asn Glu Ile Pro Asp Ile Asn Leu Asp Val Pro His Ser Tyr 
1               5                   10                  15      


Ser Val Leu Glu Arg 
            20      


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  241

Met Ile Leu Asp Leu Leu Lys 
1               5           


<210>  242
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  242

Ala Val Gly Asp Gly Ile Leu Cys Asn Thr Tyr Ile Asp Ser Tyr Lys 
1               5                   10                  15      


<210>  243
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  243

Ser Thr Glu Ser Tyr Phe Ile Pro Glu Val Arg 
1               5                   10      


<210>  244
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  244

Asn Ser Asn Asp Pro Ala Val Phe Lys Asp Asn Pro Thr Glu Asp Val 
1               5                   10                  15      


Glu Tyr Gln Cys Val Ala Asp Asn Cys His Ser His Ala Lys 
            20                  25                  30  


<210>  245
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  245

Ala Pro Ile His Phe Thr Ile Glu Lys Leu Glu Leu Asn Glu Lys 
1               5                   10                  15  


<210>  246
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  246

Ser Asp Ser Gly Thr Tyr Ile Cys Thr Ala Gly Ile Asp Lys 
1               5                   10                  


<210>  247
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  247

Gln Met Pro Val Glu Met Ser Arg Pro Ala Val Pro Leu Leu Asn Ser 
1               5                   10                  15      


Asn Asn Glu Lys 
            20  


<210>  248
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  248

Ile Ile Ser Gly Ile His Met Gln Thr Ser Glu Ser Thr Lys 
1               5                   10                  


<210>  249
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  249

Glu Gln Glu Gly Glu Tyr Tyr Cys Thr Ala Phe Asn Arg 
1               5                   10              


<210>  250
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  250

Ser Glu Leu Val Thr Val Thr Glu Ser Phe Ser Thr Pro Lys 
1               5                   10                  


<210>  251
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  251

Cys Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile 
1               5                   10                  15      


Ile Gln Lys Asp Lys 
            20      


<210>  252
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  252

Ser Asn Thr Val Gln Ile Val Val Cys Glu Met Leu Ser Gln Pro Arg 
1               5                   10                  15      


<210>  253
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  253

Cys Thr Ile Gln Val Thr His Leu Ala Gln Glu Phe Pro Glu Ile Ile 
1               5                   10                  15      


Ile Gln Lys 
            


<210>  254
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  254

Ala Pro Ile His Phe Thr Ile Glu Lys 
1               5                   


<210>  255
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  255

Met Ser Asp Pro Asn Met Glu Ala Asn Ser His Tyr Gly His Asn Asp 
1               5                   10                  15      


Asp Val Arg 
            


<210>  256
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  256

Ala His Trp Phe Glu Ile Gln His Ile Gln Pro Ser Pro Leu Gln Cys 
1               5                   10                  15      


Asn Arg 
        


<210>  257
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  257

Phe Phe Ile Val Ala Cys Asp Pro Pro Gln Lys 
1               5                   10      


<210>  258
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  258

Leu Gly Ile Lys Pro Ser Ile Asn Tyr Tyr Gln Val Ala Asp Phe Lys 
1               5                   10                  15      


<210>  259
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  259

Asp Cys Arg Asp Pro Pro Asp Tyr Trp Thr Ile His Gly Leu Trp Pro 
1               5                   10                  15      


Asp Lys 
        


<210>  260
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  260

Ser Ser Pro Ala Val Glu Gln Gln Leu Leu Val Ser Gly Pro Gly Lys 
1               5                   10                  15      


<210>  261
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  261

Arg Ile Gly Pro Ala Gly Glu Val Pro Gln Val Pro Asp Lys 
1               5                   10                  


