                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Anti-TIM-3 Antibodies

<130>  RIC/FP7158009

<150>  GB 1419092.0
<151>  2014-10-27

<150>  GB 1419089.6
<151>  2014-10-27

<160>  61    

<170>  PatentIn version 3.3

<210>  1
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Pro Gly Thr Thr Leu Glu Ile Lys 
            100                 105         


<210>  2
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Phe Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Asp Ala Thr Asn Arg Ala Thr Gly Ile Pro Thr Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Arg Arg Thr Phe Gly Arg 
                85                  90                  95      


Gly Thr Lys Leu Glu Ile Lys 
            100             


<210>  3
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr His Trp Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


<210>  4
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  5
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Ile Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ala Ser Gln Asp Ile Gly Ser Tyr Leu Ala 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Gln Ser Tyr Ser Ser Pro Pro Thr 
1               5                   


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Ala Ser Gln Ser Val Gly Ser Tyr Leu Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ala Thr Asn Arg Ala Thr 
1               5           


<210>  11
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln His Arg Arg Thr 
1               5   


<210>  12
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Gly Thr His Trp Pro Pro Thr 
1               5                   


<210>  15
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  15

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  16
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Gln Gln Tyr Gly Ser Ser Pro Ile Thr 
1               5                   


<210>  18

<400>  18
000

<210>  19
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Gly Val Val Thr Ala Leu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  20
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Ala Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Gly Ser Ser 
            20                  25                  30          


Asp Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Val Asp Thr Pro Asn Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Glu His Arg Gly Glu Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gly 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Val Val Ala Val Ala Gly Thr Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Tyr Ser Ser Gly Trp Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  23
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Tyr Ser Tyr Gly Phe Tyr Tyr Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  24
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   10  


<210>  25
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  25

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Pro Gly Val Val Thr Ala Leu Phe Asp Tyr 
1               5                   10      


<210>  27
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Gly Ser Ile Gly Ser Ser Asp Tyr Tyr Trp Gly 
1               5                   10          


<210>  28
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  28

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Glu His Arg Gly Glu Phe Asp Tyr 
1               5                   


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Gly Ser Ile Ser Ser Ser Asn Trp Trp Ser 
1               5                   10      


<210>  31
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  31

Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  32
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  32

Val Val Ala Val Ala Gly Thr Val Asp Tyr 
1               5                   10  


<210>  33
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  33

Asp Gln Tyr Ser Ser Gly Trp Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  34
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  34

Asp Leu Tyr Ser Tyr Gly Phe Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  


<210>  35
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  35
gacatccaga tgacccagtc tccctccttc atgtctgcat ctgtaggaga cagagtcacc     60

atcacttgcc gggccagtca ggacattggc agttatttag cctggtatca gcaaaaacca    120

gggaaagccc ctaaactcct gatctatgct gcatccactt tgcaaagtgg ggtcccatca    180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcaacag tctgcaacct    240

gaagattttg caacttacta ctgtcaacag agttacagtt cccctccgac tttcggccct    300

gggaccacat tggagatcaa a                                              321


<210>  36
<211>  309
<212>  DNA
<213>  Homo sapiens

<400>  36
gaaattgtgc tgactcagtc tccagccacc ctgtcttttt ctccgggtga aagagccacc     60

ctctcctgca gggccagtca gagtgttggc agctacttag cctggtacca gcagagacct    120

ggccaggctc ccaggcccct catctatgat gcaaccaaca gggccactgg catcccaacc    180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct    240

gaagattttg caacttatta ctgtcaacac cgaaggactt ttggccgggg gaccaagttg    300

gagatcaaa                                                            309


<210>  37
<211>  336
<212>  DNA
<213>  Homo sapiens

<400>  37
gatgttgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc     60

atctcctgca ggtctagtca gagcctccta catagtaatg gatacaacta tttggattgg    120

tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc    180

tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc    240

agcagggtgg aggctgagga tgttggggtt tattactgca tgcaaggtac acactggcct    300

ccgacgttcg gccaagggac caaggtggaa ctcaaa                              336


<210>  38
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  38
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaca    120

cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccat caccttcggc    300

caagggacac gactggagat taaa                                           324


<210>  39
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  39
gaaacgacac tcacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc     60

ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcaaaaa    120

attggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca    180

gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag    240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccaat caccttcggc    300

caagggacac gactggagat taaa                                           324


<210>  40
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  40
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac    180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaagccct    300

ggggtggtga ctgccctctt tgactactgg ggccagggaa ccctggtcac cgtctcaagc    360


<210>  41
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  41
caggtgcagc tgcaggagtc gggcccagga ctggtgaagg cttcggagac cctgtccctc     60

acctgcactg tctctggtgg ctccatcggc agtagtgatt actactgggg ctggatccgc    120

cagcccccag ggaagggact ggagtggatt gggagtatct attatagtgg gagcacctac    180

tacaacccct ccctcaagag tcgagtcacc atgtcagtag acacgcccaa caatcagttc    240

tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagga    300

gaacatagag gggaatttga ctactggggc cagggcaccc tggtcaccgt ctcaagc       357


<210>  42
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  42
caggtgcagc tgcaggagtc cggcccagga ctggtgaagc cttcggggac cctgtccctc     60

acctgcgctg tctctggtgg ctccattagc agtagtaact ggtggagttg ggtccgccag    120

cccccaggga aggggctgga gtggattggg gaaatctatc atagtgggag caccaactac    180

aacccgtccc tcaagagtcg agtcaccata tcagtagaca agtccaagaa ccagttctcc    240

ctgaagctga gctctgtgac cgccgcggac acggccgtgt attactgtgc gagagtagta    300

gcagtggctg gtacggttga ctactggggc cagggaaccc tggtcaccgt ctcaagc       357


<210>  43
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  43
gaggtccagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac    180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagatcag    300

tatagcagtg gctggtacta ctacggtatg gacgtctggg gccaagggac cacggtcacc    360

gtctcaagc                                                            369


<210>  44
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  44
caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctggggcctc agtgaaggtt     60

tcctgcaagg catctggata caccttcacc agctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaata atcaacccta gtggtggtag cacaagctac    180

gcacagaagt tccagggcag agtcaccatg accagggaca cgtccacgag cacagtctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagagattta    300

tacagctatg gtttttacta ctacggtatg gacgtctggg gccaagggac cacggtcacc    360

gtctcaagc                                                            369


<210>  45
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  45

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  46
<211>  110
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Light chain variable domain sequence for 
       anti-TIM-3 antibody A11_gI

<400>  46

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Trp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Glu Thr Trp Asp Ser Ser Leu 
                85                  90                  95      


Ser Ala Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser 
1               5                   10              


<210>  48
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Asn Asn Trp Arg Pro Ser 
1               5           


<210>  49
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  49

Glu Thr Trp Asp Ser Ser Leu Ser Ala Gly Val 
1               5                   10      


<210>  50
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  51
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Heavy chain variable domain sequence for 
       anti-TIM-3 antibody clone A11_gI

<400>  51

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Tyr Val Ala Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  52
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 
1               5                   10  


<210>  53
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  53

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Gly Tyr Val Ala Gly Phe Asp Tyr 
1               5               


<210>  55
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  55
cagtctgtcg tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tggccatcag cggacttcag    240

actggggacg aggccgatta ttactgcgaa acatgggata gcagcctgag tgctggggta    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  56
<211>  330
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence: Nucleotide sequence of heavy chain variable 
       domain sequence for anti-TIM-3 antibody clone A11_gI

<400>  56
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa agtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact cctcatttat ggcaataatt ggcgaccctc agggattcct    180

gaccgcttct ctggctccaa gtctggcacc tcagccaccc tgggcatcac cggacttcag    240

actggggacg aggccgatta ttactgcgaa acatgggata gcagcctgag tgctggggta    300

ttcggcggag ggaccaagct gaccgtccta                                     330


<210>  57
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  57
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc     60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc    120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac    180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccttg    240

aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggctacgtg    300

gctggctttg actactgggg ccagggaacc ctggtcaccg tctcaagc                 348


<210>  58
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  58

Ser Tyr Tyr Met His 
1               5   


<210>  59
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Ser Asp Tyr Tyr Trp Gly 
1               5           


<210>  60
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  60

Ser Ser Asn Trp Trp Ser 
1               5       


<210>  61
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Tyr Tyr Trp Ser 
1               5   


