                         SEQUENCE LISTING

<110>  ALPER, HAL
       BLAZECK, JOHN
       HILL, ANDREW
 
<120>  ENGINEERED FUNGI FOR ITACONIC ACID PRODUCTION

<130>  UTFB.P1040WO

<140>  Unknown
<141>  2015-10-29

<150>  62072734
<151>  2014-10-30

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  1
ggaacggtag atctcgagcg tcccaaaacc ttctc                                  35


<210>  2
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  2
gtggacgggc cggcgtttgg cgcccgtttt ttcg                                   34


<210>  3
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  3
gtattgattg taattctgta aatctatttc                                        30


<210>  4
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  4
cttgctgcaa agaccgcagg aaggacaatg cttgcagagt gtaggggggc ttcgctgtgg       60


<210>  5
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  5
tttcatacag gctacggagc ttgacgacta ccacagcgaa gcccccctac actctgcaag       60


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  6
gaggctctct gccgttgccc                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  7
ttcttggggg actgttggcc                                                   20


<210>  8
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  8
agatgaagta accttcctgg ccagatc                                           27


<210>  9
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  9
ccgtccagct ggtcgaccag                                                   20


<210>  10
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  10
ctccttcctt ttcggttaga gcggatgtgg ggggagggcg tgaatgtaa                   49


<210>  11
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  11
gagtggcgcg ccatgatttc tgctattcgt ccc                                    33


<210>  12
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  12
gcacttaatt aattagagct tgaggccaac ga                                     32


<210>  13
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  13
gagtggcgcg ccatgcttaa ggagcgattc gcc                                    33


<210>  14
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  14
gagtggcgcg ccatgctggc ttctcgagtt tc                                     32


<210>  15
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  15
gcacttaatt aattatttct tggaggcagc c                                      31


<210>  16
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  16
gagtggcgcg ccatggccaa caacttcctc aacttc                                 36


<210>  17
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  17
gagtggcgcg ccatgaccaa acaatctgcg g                                      31


<210>  18
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  18
gcacttaatt aattatacca gtggcgattt ca                                     32


<210>  19
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  19
gagtggcgcg ccatgtctaa tccttttgca tacttag                                37


<210>  20
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  20
gcacttaatt aactactttg ccatttttct aatca                                  35


<210>  21
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  21
aactctagat atgtctgata aaag                                              24


<210>  22
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  22
ttagcggccg catactactg tatattc                                           27


<210>  23
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  23
aacgcggccg cctgcagact aaattta                                           27


<210>  24
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  24
ttcagatctc taacagttaa tcttc                                             25


<210>  25
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  25
actgggcgcg ccatgattga aggaatctcc tttgcg                                 36


<210>  26
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  26
actgttaatt aactaacaag gatcaataat accctgctc                              39


<210>  27
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  27
acgtgctcgc gacgtctgct tctgcca                                           27


<210>  28
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  28
tggcagaagc agacgtcgcg agcacgt                                           27


<210>  29
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  29
gacgtgctcc ggacgtctgc ttctgcca                                          28


<210>  30
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  30
tggcagaagc agacgtccgg agcacgtc                                          28


<210>  31
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  31
gactggcgcg ccatgagagc ccttctgaac aag                                    33


<210>  32
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  32
gtccttaatt aatcatctca tcattcgtcg gac                                    33


<210>  33
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  33
gccgaacctt ggaagtccct                                                   20


<210>  34
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  34
gtccttaatt aactaaagaa tctccatgat cttctcatag atggt                       45


<210>  35
<211>  56
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic primer

<400>  35
gactggcgcg ccatggtttc atcagatacc aagaaggccg aaccttggaa gtccct           56


<210>  36
<211>  490
<212>  PRT
<213>  A. terreus

<400>  36

Met Thr Lys Gln Ser Ala Asp Ser Asn Ala Lys Ser Gly Val Thr Ser 
1               5                   10                  15      


Glu Ile Cys His Trp Ala Ser Asn Leu Ala Thr Asp Asp Ile Pro Ser 
            20                  25                  30          


Asp Val Leu Glu Arg Ala Lys Tyr Leu Ile Leu Asp Gly Ile Ala Cys 
        35                  40                  45              


Ala Trp Val Gly Ala Arg Val Pro Trp Ser Glu Lys Tyr Val Gln Ala 
    50                  55                  60                  


Thr Met Ser Phe Glu Pro Pro Gly Ala Cys Arg Val Ile Gly Tyr Gly 
65                  70                  75                  80  


Gln Lys Leu Gly Pro Val Ala Ala Ala Met Thr Asn Ser Ala Phe Ile 
                85                  90                  95      


Gln Ala Thr Glu Leu Asp Asp Tyr His Ser Glu Ala Pro Leu His Ser 
            100                 105                 110         


Ala Ser Ile Val Leu Pro Ala Val Phe Ala Ala Ser Glu Val Leu Ala 
        115                 120                 125             


Glu Gln Gly Lys Thr Ile Ser Gly Ile Asp Val Ile Leu Ala Ala Ile 
    130                 135                 140                 


Val Gly Phe Glu Ser Gly Pro Arg Ile Gly Lys Ala Ile Tyr Gly Ser 
145                 150                 155                 160 


Asp Leu Leu Asn Asn Gly Trp His Cys Gly Ala Val Tyr Gly Ala Pro 
                165                 170                 175     


Ala Gly Ala Leu Ala Thr Gly Lys Leu Leu Gly Leu Thr Pro Asp Ser 
            180                 185                 190         


Met Glu Asp Ala Leu Gly Ile Ala Cys Thr Gln Ala Cys Gly Leu Met 
        195                 200                 205             


Ser Ala Gln Tyr Gly Gly Met Val Lys Arg Val Gln His Gly Phe Ala 
    210                 215                 220                 


Ala Arg Asn Gly Leu Leu Gly Gly Leu Leu Ala His Gly Gly Tyr Glu 
225                 230                 235                 240 


Ala Met Lys Gly Val Leu Glu Arg Ser Tyr Gly Gly Phe Leu Lys Met 
                245                 250                 255     


Phe Thr Lys Gly Asn Gly Arg Glu Pro Pro Tyr Lys Glu Glu Glu Val 
            260                 265                 270         


Val Ala Gly Leu Gly Ser Phe Trp His Thr Phe Thr Ile Arg Ile Lys 
        275                 280                 285             


Leu Tyr Ala Cys Cys Gly Leu Val His Gly Pro Val Glu Ala Ile Glu 
    290                 295                 300                 


Asn Leu Gln Gly Arg Tyr Pro Glu Leu Leu Asn Arg Ala Asn Leu Ser 
305                 310                 315                 320 


Asn Ile Arg His Val His Val Gln Leu Ser Thr Ala Ser Asn Ser His 
                325                 330                 335     


Cys Gly Trp Ile Pro Glu Glu Arg Pro Ile Ser Ser Ile Ala Gly Gln 
            340                 345                 350         


Met Ser Val Ala Tyr Ile Leu Ala Val Gln Leu Val Asp Gln Gln Cys 
        355                 360                 365             


Leu Leu Ser Gln Phe Ser Glu Phe Asp Asp Asn Leu Glu Arg Pro Glu 
    370                 375                 380                 


Val Trp Asp Leu Ala Arg Lys Val Thr Ser Ser Gln Ser Glu Glu Phe 
385                 390                 395                 400 


Asp Gln Asp Gly Asn Cys Leu Ser Ala Gly Arg Val Arg Ile Glu Phe 
                405                 410                 415     


Asn Asp Gly Ser Ser Ile Thr Glu Ser Val Glu Lys Pro Leu Gly Val 
            420                 425                 430         


Lys Glu Pro Met Pro Asn Glu Arg Ile Leu His Lys Tyr Arg Thr Leu 
        435                 440                 445             


Ala Gly Ser Val Thr Asp Glu Ser Arg Val Lys Glu Ile Glu Asp Leu 
    450                 455                 460                 


Val Leu Gly Leu Asp Arg Leu Thr Asp Ile Ser Pro Leu Leu Glu Leu 
465                 470                 475                 480 


Leu Asn Cys Pro Val Lys Ser Pro Leu Val 
                485                 490 


<210>  37
<211>  869
<212>  PRT
<213>  Y. lipolytica

<400>  37

Met Pro Gln Gln Ala Met Asp Ile Lys Gly Lys Ala Lys Ser Val Pro 
1               5                   10                  15      


Met Pro Glu Glu Asp Asp Leu Asp Ser His Phe Val Gly Pro Ile Ser 
            20                  25                  30          


Pro Arg Pro His Gly Ala Asp Glu Ile Ala Gly Tyr Val Gly Cys Glu 
        35                  40                  45              


Asp Asp Glu Asp Glu Leu Glu Glu Leu Gly Met Leu Gly Arg Ser Ala 
    50                  55                  60                  


Ser Thr His Phe Ser Tyr Ala Glu Glu Arg His Leu Ile Glu Val Asp 
65                  70                  75                  80  


Ala Lys Tyr Arg Ala Leu His Gly His Leu Pro His Gln His Ser Gln 
                85                  90                  95      


Ser Pro Val Ser Arg Ser Ser Ser Phe Val Arg Ala Glu Met Asn His 
            100                 105                 110         


Pro Pro Pro Pro Pro Ser Ser His Thr His Gln Gln Pro Glu Asp Asp 
        115                 120                 125             


Asp Ala Ser Ser Thr Arg Ser Arg Ser Ser Ser Arg Ala Ser Gly Arg 
    130                 135                 140                 


Lys Phe Asn Arg Asn Arg Thr Lys Ser Gly Ser Ser Leu Ser Lys Gly 
145                 150                 155                 160 


Leu Gln Gln Leu Asn Met Thr Gly Ser Leu Glu Glu Glu Pro Tyr Glu 
                165                 170                 175     


Ser Asp Asp Asp Ala Arg Leu Ser Ala Glu Asp Asp Ile Val Tyr Asp 
            180                 185                 190         


Ala Thr Gln Lys Asp Thr Cys Lys Pro Ile Ser Pro Thr Leu Lys Arg 
        195                 200                 205             


Thr Arg Thr Lys Asp Asp Met Lys Asn Met Ser Ile Asn Asp Val Lys 
    210                 215                 220                 


Ile Thr Thr Thr Thr Glu Asp Pro Leu Val Ala Gln Glu Leu Ser Met 
225                 230                 235                 240 


Met Phe Glu Lys Val Gln Tyr Cys Arg Asp Leu Arg Asp Lys Tyr Gln 
                245                 250                 255     


Thr Val Ser Leu Gln Lys Asp Gly Asp Asn Pro Lys Asp Asp Lys Thr 
            260                 265                 270         


His Trp Lys Ile Tyr Pro Glu Pro Pro Pro Pro Ser Trp His Glu Thr 
        275                 280                 285             


Glu Lys Arg Phe Arg Gly Ser Ser Lys Lys Glu His Gln Lys Lys Asp 
    290                 295                 300                 


Pro Thr Met Asp Glu Phe Lys Phe Glu Asp Cys Glu Ile Pro Gly Pro 
305                 310                 315                 320 


Asn Asp Met Val Phe Lys Arg Asp Pro Thr Cys Val Tyr Gln Val Tyr 
                325                 330                 335     


Glu Asp Glu Ser Ser Leu Asn Glu Asn Lys Pro Phe Val Ala Ile Pro 
            340                 345                 350         


Ser Ile Arg Asp Tyr Tyr Met Asp Leu Glu Asp Leu Ile Val Ala Ser 
        355                 360                 365             


Ser Asp Gly Pro Ala Lys Ser Phe Ala Phe Arg Arg Leu Gln Tyr Leu 
    370                 375                 380                 


Glu Ala Lys Trp Asn Leu Tyr Tyr Leu Leu Asn Glu Tyr Thr Glu Thr 
385                 390                 395                 400 


Thr Glu Ser Lys Thr Asn Pro His Arg Asp Phe Tyr Asn Val Arg Lys 
                405                 410                 415     


Val Asp Thr His Val His His Ser Ala Cys Met Asn Gln Lys His Leu 
            420                 425                 430         


Leu Arg Phe Ile Lys Tyr Lys Met Lys Asn Cys Pro Asp Glu Val Val 
        435                 440                 445             


Ile His Arg Asp Gly Arg Glu Leu Thr Leu Ser Gln Val Phe Glu Ser 
    450                 455                 460                 


Leu Asn Leu Thr Ala Tyr Asp Leu Ser Ile Asp Thr Leu Asp Met His 
465                 470                 475                 480 


Ala His Lys Asp Ser Phe His Arg Phe Asp Lys Phe Asn Leu Lys Tyr 
                485                 490                 495     


Asn Pro Val Gly Glu Ser Arg Leu Arg Glu Ile Phe Leu Lys Thr Asp 
            500                 505                 510         


Asn Tyr Ile Gln Gly Arg Tyr Leu Ala Glu Ile Thr Lys Glu Val Phe 
        515                 520                 525             


Gln Asp Leu Glu Asn Ser Lys Tyr Gln Met Ala Glu Tyr Arg Ile Ser 
    530                 535                 540                 


Ile Tyr Gly Arg Ser Lys Asp Glu Trp Asp Lys Leu Ala Ala Trp Val 
545                 550                 555                 560 


Leu Asp Asn Lys Leu Phe Ser Pro Asn Val Arg Trp Leu Ile Gln Val 
                565                 570                 575     


Pro Arg Leu Tyr Asp Ile Tyr Lys Lys Ala Gly Leu Val Asn Thr Phe 
            580                 585                 590         


Ala Asp Ile Val Gln Asn Val Phe Glu Pro Leu Phe Glu Val Thr Lys 
        595                 600                 605             


Asp Pro Ser Thr His Pro Lys Leu His Val Phe Leu Gln Arg Val Val 
    610                 615                 620                 


Gly Phe Asp Ser Val Asp Asp Glu Ser Lys Leu Asp Arg Arg Phe His 
625                 630                 635                 640 


Arg Lys Phe Pro Thr Ala Ala Tyr Trp Asp Ser Ala Gln Asn Pro Pro 
                645                 650                 655     


Tyr Ser Tyr Trp Gln Tyr Tyr Leu Tyr Ala Asn Met Ala Ser Ile Asn 
            660                 665                 670         


Thr Trp Arg Gln Arg Leu Gly Tyr Asn Thr Phe Glu Leu Arg Pro His 
        675                 680                 685             


Ala Gly Glu Ala Gly Asp Pro Glu His Leu Leu Cys Thr Tyr Leu Val 
    690                 695                 700                 


Ala Gln Gly Ile Asn His Gly Ile Leu Leu Arg Lys Val Pro Phe Ile 
705                 710                 715                 720 


Gln Tyr Leu Tyr Tyr Leu Asp Gln Ile Pro Ile Ala Met Ser Pro Val 
                725                 730                 735     


Ser Asn Asn Ala Leu Phe Leu Thr Phe Asp Lys Asn Pro Phe Tyr Ser 
            740                 745                 750         


Tyr Phe Lys Arg Gly Leu Asn Val Ser Leu Ser Ser Asp Asp Pro Leu 
        755                 760                 765             


Gln Phe Ala Tyr Thr Lys Glu Ala Leu Ile Glu Glu Tyr Ser Val Ala 
    770                 775                 780                 


Ala Leu Ile Tyr Lys Leu Ser Asn Val Asp Met Cys Glu Leu Ala Arg 
785                 790                 795                 800 


Asn Ser Val Leu Gln Ser Gly Phe Glu Arg Ile Ile Lys Glu His Trp 
                805                 810                 815     


Ile Gly Glu Asn Tyr Glu Ile His Gly Pro Glu Gly Asn Thr Ile Gln 
            820                 825                 830         


Lys Thr Asn Val Pro Asn Val Arg Leu Ala Phe Arg Asp Glu Thr Leu 
        835                 840                 845             


Thr His Glu Leu Ala Leu Val Asp Lys Tyr Thr Asn Leu Glu Glu Phe 
    850                 855                 860                 


Glu Arg Leu His Gly 
865                 


<210>  38
<211>  889
<212>  PRT
<213>  O. cuniculus

<400>  38

Met Ser Asn Pro Phe Ala Tyr Leu Ala Glu Pro Leu Asp Pro Ala Gln 
1               5                   10                  15      


Pro Gly Lys Lys Phe Phe Asn Leu Asn Lys Leu Asp Tyr Ser Arg Tyr 
            20                  25                  30          


Gly Arg Leu Pro Phe Ser Ile Arg Val Leu Leu Glu Ala Ala Val Arg 
        35                  40                  45              


Asn Cys Asp Lys Phe Leu Val Lys Lys Glu Asp Ile Glu Asn Ile Leu 
    50                  55                  60                  


Asn Trp Asn Val Thr Gln His Met Asn Ile Glu Val Pro Phe Lys Pro 
65                  70                  75                  80  


Ala Arg Val Ile Leu Gln Asp Phe Thr Gly Val Pro Ser Val Val Asp 
                85                  90                  95      


Phe Ala Ala Met Arg Asp Ala Val Lys Lys Leu Gly Gly Asp Pro Glu 
            100                 105                 110         


Lys Ile Asn Pro Ile Cys Pro Val Asp Leu Val Ile Asp His Ser Ile 
        115                 120                 125             


Gln Val Asp Phe Asn Arg Arg Ala Asp Ser Leu Gln Lys Asn Gln Asp 
    130                 135                 140                 


Leu Glu Phe Glu Arg Asn Arg Glu Arg Phe Glu Phe Leu Lys Trp Gly 
145                 150                 155                 160 


Ser Lys Ala Phe Arg Asn Met Arg Ile Ile Pro Pro Gly Ser Gly Ile 
                165                 170                 175     


Ile His Gln Val Asn Leu Glu Tyr Leu Ala Arg Val Val Phe Asp Gln 
            180                 185                 190         


Asp Gly Tyr Tyr Tyr Pro Asp Ser Leu Val Gly Thr Asp Ser His Thr 
        195                 200                 205             


Thr Met Ile Asp Gly Leu Gly Val Leu Gly Trp Gly Val Gly Gly Ile 
    210                 215                 220                 


Glu Ala Glu Ala Val Met Leu Gly Gln Pro Ile Ser Met Val Leu Pro 
225                 230                 235                 240 


Gln Val Ile Gly Tyr Arg Leu Met Gly Lys Pro His Pro Leu Val Thr 
                245                 250                 255     


Ser Thr Asp Ile Val Leu Thr Ile Thr Lys His Leu Arg Gln Val Gly 
            260                 265                 270         


Val Val Gly Lys Phe Val Glu Phe Phe Gly Leu Gly Val Ala Gln Leu 
        275                 280                 285             


Ser Ile Ala Asp Arg Ala Thr Ile Ala Asn Met Cys Pro Glu Tyr Gly 
    290                 295                 300                 


Ala Thr Ala Thr Phe Phe Pro Val Asp Glu Val Ser Ile Lys Tyr Leu 
305                 310                 315                 320 


Val Gln Thr Gly Arg Asp Glu Ser Lys Val Lys Gln Ile Arg Lys Tyr 
                325                 330                 335     


Leu Gln Ala Val Gly Met Phe Arg Asp Tyr Ser Asp Pro Ser Gln Asp 
            340                 345                 350         


Pro Asp Phe Thr Gln Val Val Glu Leu Asp Leu Lys Thr Val Val Pro 
        355                 360                 365             


Cys Cys Ser Gly Pro Lys Arg Pro Gln Asp Lys Val Ala Val Ser Asp 
    370                 375                 380                 


Met Lys Lys Asp Phe Glu Ser Cys Leu Gly Ala Lys Gln Gly Phe Lys 
385                 390                 395                 400 


Gly Phe Gln Val Ala Pro Asp His His Asn Asp His Lys Thr Phe Ile 
                405                 410                 415     


Tyr Asn Asp Ser Glu Phe Thr Leu Ser His Gly Ser Val Val Ile Ala 
            420                 425                 430         


Ala Ile Thr Ser Cys Thr Asn Thr Ser Asn Pro Ser Val Met Leu Gly 
        435                 440                 445             


Ala Gly Leu Leu Ala Lys Lys Ala Val Asp Ala Gly Leu Asn Val Lys 
    450                 455                 460                 


Pro Tyr Val Lys Thr Ser Leu Ser Pro Gly Ser Gly Val Val Thr Tyr 
465                 470                 475                 480 


Tyr Leu Arg Glu Ser Gly Val Met Pro Tyr Leu Ser Gln Leu Gly Phe 
                485                 490                 495     


Asp Val Val Gly Tyr Gly Cys Met Thr Cys Ile Gly Asn Ser Gly Pro 
            500                 505                 510         


Leu Pro Glu Pro Val Val Glu Ala Ile Thr Gln Gly Asp Leu Val Ala 
        515                 520                 525             


Val Gly Val Leu Ser Gly Asn Arg Asn Phe Glu Gly Arg Val His Pro 
    530                 535                 540                 


Asn Thr Arg Ala Asn Tyr Leu Ala Ser Pro Pro Leu Val Ile Ala Tyr 
545                 550                 555                 560 


Ala Ile Ala Gly Thr Ile Arg Ile Asp Phe Glu Lys Glu Pro Leu Gly 
                565                 570                 575     


Thr Asn Ala Lys Gly Gln Gln Val Phe Leu Arg Asp Ile Trp Pro Thr 
            580                 585                 590         


Arg Glu Glu Ile Gln Ala Val Glu Arg Gln Tyr Val Ile Pro Gly Met 
        595                 600                 605             


Phe Thr Glu Val Tyr Gln Lys Ile Glu Thr Val Asn Ala Ser Trp Asn 
    610                 615                 620                 


Ala Leu Ala Ala Pro Ser Asp Lys Leu Tyr Leu Trp Asn Pro Lys Ser 
625                 630                 635                 640 


Thr Tyr Ile Lys Ser Pro Pro Phe Phe Glu Asn Leu Thr Leu Asp Leu 
                645                 650                 655     


Gln Pro Pro Lys Ser Ile Val Asp Ala Tyr Val Leu Leu Asn Leu Gly 
            660                 665                 670         


Asp Ser Val Thr Thr Asp His Ile Ser Pro Ala Gly Asn Ile Ala Arg 
        675                 680                 685             


Asn Ser Pro Ala Ala Arg Tyr Leu Thr Asn Arg Gly Leu Thr Pro Arg 
    690                 695                 700                 


Glu Phe Asn Ser Tyr Gly Ser Arg Arg Gly Asn Asp Ala Ile Met Ala 
705                 710                 715                 720 


Arg Gly Thr Phe Ala Asn Ile Arg Leu Leu Asn Arg Phe Leu Asn Lys 
                725                 730                 735     


Gln Ala Pro Gln Thr Ile His Leu Pro Ser Gly Glu Thr Leu Asp Val 
            740                 745                 750         


Phe Asp Ala Ala Glu Arg Tyr Gln Gln Glu Gly His Pro Leu Ile Val 
        755                 760                 765             


Leu Ala Gly Lys Glu Tyr Gly Ser Gly Ser Ser Arg Asp Trp Ala Ala 
    770                 775                 780                 


Lys Gly Pro Phe Leu Leu Gly Ile Lys Ala Val Leu Ala Glu Ser Tyr 
785                 790                 795                 800 


Glu Arg Ile His Arg Ser Asn Leu Val Gly Met Gly Val Ile Pro Leu 
                805                 810                 815     


Glu Tyr Leu Pro Gly Glu Asn Ala Asp Ser Leu Gly Leu Thr Gly Arg 
            820                 825                 830         


Glu Arg Tyr Thr Ile Ile Ile Pro Glu Asn Leu Thr Pro Arg Met His 
        835                 840                 845             


Val Gln Val Lys Leu Asp Thr Gly Lys Thr Phe Gln Ala Val Ile Arg 
    850                 855                 860                 


Phe Asp Thr Asp Val Glu Leu Thr Tyr Leu His Asn Gly Gly Ile Leu 
865                 870                 875                 880 


Asn Tyr Met Ile Arg Lys Met Ala Lys 
                885                 


<210>  39
<211>  779
<212>  PRT
<213>  Y. lipolytica

<400>  39

Met Leu Ala Ser Arg Val Ser Ile Lys Ala Pro Arg Leu Ala Arg Ser 
1               5                   10                  15      


Leu Ala Thr Thr Thr Asn Ala Ser Leu Asn Leu Asp Ser Lys Val Arg 
            20                  25                  30          


Met Asn Asn Trp Glu Ala Asn Asn Phe Leu Asn Phe Lys Lys His Thr 
        35                  40                  45              


Glu Asn Val Gln Ile Val Lys Glu Arg Leu Asn Arg Pro Leu Thr Tyr 
    50                  55                  60                  


Ala Glu Lys Ile Leu Tyr Gly His Leu Asp Lys Pro His Glu Gln Glu 
65                  70                  75                  80  


Ile Val Arg Gly Gln Ser Tyr Leu Lys Leu Arg Pro Asp Arg Ala Ala 
                85                  90                  95      


Cys Gln Asp Ala Thr Ala Gln Met Ala Ile Leu Gln Phe Met Ser Ala 
            100                 105                 110         


Gly Ile Pro Thr Val Gln Thr Pro Thr Thr Val His Cys Asp His Leu 
        115                 120                 125             


Ile Gln Ala Gln Val Gly Gly Glu Gln Asp Leu Ala Arg Ala Ile Asp 
    130                 135                 140                 


Ile Asn Lys Glu Val Tyr Asn Phe Leu Gly Thr Ala Ser Ala Lys Tyr 
145                 150                 155                 160 


Asp Ile Gly Phe Trp Lys Ala Gly Ser Gly Ile Ile His Gln Ile Ile 
                165                 170                 175     


Leu Glu Asn Tyr Ala Phe Pro Gly Ala Leu Leu Ile Gly Ser Asp Ser 
            180                 185                 190         


His Thr Pro Asn Ala Gly Gly Leu Gly Met Leu Ala Ile Gly Val Gly 
        195                 200                 205             


Gly Ala Asp Val Val Asp Val Met Ala Gly Leu Pro Trp Glu Leu Lys 
    210                 215                 220                 


Ala Pro Lys Ile Ile Gly Val Lys Leu Thr Gly Lys Leu Ser Gly Trp 
225                 230                 235                 240 


Thr Ser Pro Lys Asp Ile Ile Leu Lys Val Ala Gly Ile Leu Thr Val 
                245                 250                 255     


Lys Gly Gly Thr Gly Ala Ile Val Glu Tyr Phe Gly Asp Gly Val Asp 
            260                 265                 270         


Asn Leu Ser Cys Thr Gly Met Gly Thr Ile Cys Asn Met Gly Ala Glu 
        275                 280                 285             


Ile Gly Ala Thr Thr Ser Thr Phe Pro Phe Asn Glu Arg Met Ala Asp 
    290                 295                 300                 


Tyr Leu Asn Ala Thr Gly Arg Lys Glu Ile Ala Asp Phe Ala Arg Leu 
305                 310                 315                 320 


Tyr Asn His Phe Leu Ser Ala Asp Glu Gly Cys Glu Tyr Asp Gln Leu 
                325                 330                 335     


Ile Glu Ile Asp Leu Asn Thr Leu Glu Pro Tyr Val Asn Gly Pro Phe 
            340                 345                 350         


Thr Pro Asp Leu Ala Thr Pro Ile Ser Lys Leu Lys Asp Val Ala Val 
        355                 360                 365             


Glu Asn Gly Trp Pro Leu Glu Val Lys Val Gly Leu Ile Gly Ser Cys 
    370                 375                 380                 


Thr Asn Ser Ser Tyr Glu Asp Met Glu Arg Ser Ala Ser Ile Ala Lys 
385                 390                 395                 400 


Asp Ala Met Ala His Gly Leu Lys Ser Lys Ser Ile Tyr Thr Val Thr 
                405                 410                 415     


Pro Gly Ser Glu Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Gln Leu 
            420                 425                 430         


Gln Thr Phe Leu Asp Phe Gly Gly Ile Val Leu Ala Asn Ala Cys Gly 
        435                 440                 445             


Pro Cys Ile Gly Gln Trp Asp Arg Arg Asp Ile Lys Lys Gly Glu Lys 
    450                 455                 460                 


Asn Thr Ile Val Ser Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn Asp 
465                 470                 475                 480 


Ser Asn Pro Ala Thr His Ala Phe Val Thr Ser Pro Asp Leu Val Thr 
                485                 490                 495     


Ala Phe Ala Ile Ala Gly Asp Leu Arg Phe Asn Pro Leu Thr Asp Ser 
            500                 505                 510         


Leu Lys Asp Ser Glu Gly Lys Glu Phe Lys Leu Lys Glu Pro Thr Gly 
        515                 520                 525             


Lys Gly Leu Pro Asp Arg Gly Tyr Asp Pro Gly Met Asp Thr Tyr Gln 
    530                 535                 540                 


Ala Pro Pro Ala Asp Arg Ser Ala Val Glu Val Asp Val Ser Pro Thr 
545                 550                 555                 560 


Ser Asp Arg Leu Gln Ile Leu Lys Pro Phe Lys Pro Trp Asp Gly Lys 
                565                 570                 575     


Asp Gly Ile Asp Met Pro Ile Leu Ile Lys Ser Leu Gly Lys Thr Thr 
            580                 585                 590         


Thr Asp His Ile Ser Gln Ala Gly Pro Trp Leu Lys Tyr Arg Gly His 
        595                 600                 605             


Leu Gln Asn Ile Ser Asn Asn Tyr Met Ile Gly Ala Ile Asn Ala Glu 
    610                 615                 620                 


Asn Glu Glu Ala Asn Asn Val Arg Asn Gln Ile Thr Gly Glu Trp Gly 
625                 630                 635                 640 


Gly Val Pro Glu Thr Ala Ile Ala Tyr Arg Asp Asn Gly Ile Arg Trp 
                645                 650                 655     


Val Val Val Gly Gly Asp Asn Phe Gly Glu Gly Ser Ser Arg Glu His 
            660                 665                 670         


Ala Ala Leu Glu Pro Arg Phe Leu Gly Gly Phe Ala Ile Ile Thr Lys 
        675                 680                 685             


Ser Phe Ala Arg Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu Leu 
    690                 695                 700                 


Pro Leu Asn Phe Val Asn Gly Ala Asp Tyr Asp Lys Ile Gln Pro Ser 
705                 710                 715                 720 


Asp Lys Ile Ser Ile Leu Gly Leu Lys Asp Leu Ala Pro Gly Lys Asn 
                725                 730                 735     


Val Thr Ile Glu Val Thr Pro Lys Asp Gly Ala Lys Trp Thr Thr Glu 
            740                 745                 750         


Val Ser His Thr Tyr Asn Ser Glu Gln Leu Glu Trp Phe Lys Tyr Gly 
        755                 760                 765             


Ser Ala Leu Asn Lys Met Ala Ala Ser Lys Lys 
    770                 775                 


<210>  40
<211>  743
<212>  PRT
<213>  Y. lipolytica

<400>  40

Met Ala Asn Asn Phe Leu Asn Phe Lys Lys His Thr Glu Asn Val Gln 
1               5                   10                  15      


Ile Val Lys Glu Arg Leu Asn Arg Pro Leu Thr Tyr Ala Glu Lys Ile 
            20                  25                  30          


Leu Tyr Gly His Leu Asp Lys Pro His Glu Gln Glu Ile Val Arg Gly 
        35                  40                  45              


Gln Ser Tyr Leu Lys Leu Arg Pro Asp Arg Ala Ala Cys Gln Asp Ala 
    50                  55                  60                  


Thr Ala Gln Met Ala Ile Leu Gln Phe Met Ser Ala Gly Ile Pro Thr 
65                  70                  75                  80  


Val Gln Thr Pro Thr Thr Val His Cys Asp His Leu Ile Gln Ala Gln 
                85                  90                  95      


Val Gly Gly Glu Gln Asp Leu Ala Arg Ala Ile Asp Ile Asn Lys Glu 
            100                 105                 110         


Val Tyr Asn Phe Leu Gly Thr Ala Ser Ala Lys Tyr Asp Ile Gly Phe 
        115                 120                 125             


Trp Lys Ala Gly Ser Gly Ile Ile His Gln Ile Ile Leu Glu Asn Tyr 
    130                 135                 140                 


Ala Phe Pro Gly Ala Leu Leu Ile Gly Ser Asp Ser His Thr Pro Asn 
145                 150                 155                 160 


Ala Gly Gly Leu Gly Met Leu Ala Ile Gly Val Gly Gly Ala Asp Val 
                165                 170                 175     


Val Asp Val Met Ala Gly Leu Pro Trp Glu Leu Lys Ala Pro Lys Ile 
            180                 185                 190         


Ile Gly Val Lys Leu Thr Gly Lys Leu Ser Gly Trp Thr Ser Pro Lys 
        195                 200                 205             


Asp Ile Ile Leu Lys Val Ala Gly Ile Leu Thr Val Lys Gly Gly Thr 
    210                 215                 220                 


Gly Ala Ile Val Glu Tyr Phe Gly Asp Gly Val Asp Asn Leu Ser Cys 
225                 230                 235                 240 


Thr Gly Met Gly Thr Ile Cys Asn Met Gly Ala Glu Ile Gly Ala Thr 
                245                 250                 255     


Thr Ser Thr Phe Pro Phe Asn Glu Arg Met Ala Asp Tyr Leu Asn Ala 
            260                 265                 270         


Thr Gly Arg Lys Glu Ile Ala Asp Phe Ala Arg Leu Tyr Asn His Phe 
        275                 280                 285             


Leu Ser Ala Asp Glu Gly Cys Glu Tyr Asp Gln Leu Ile Glu Ile Asp 
    290                 295                 300                 


Leu Asn Thr Leu Glu Pro Tyr Val Asn Gly Pro Phe Thr Pro Asp Leu 
305                 310                 315                 320 


Ala Thr Pro Ile Ser Lys Leu Lys Asp Val Ala Val Glu Asn Gly Trp 
                325                 330                 335     


Pro Leu Glu Val Lys Val Gly Leu Ile Gly Ser Cys Thr Asn Ser Ser 
            340                 345                 350         


Tyr Glu Asp Met Glu Arg Ser Ala Ser Ile Ala Lys Asp Ala Met Ala 
        355                 360                 365             


His Gly Leu Lys Ser Lys Ser Ile Tyr Thr Val Thr Pro Gly Ser Glu 
    370                 375                 380                 


Gln Ile Arg Ala Thr Ile Glu Arg Asp Gly Gln Leu Gln Thr Phe Leu 
385                 390                 395                 400 


Asp Phe Gly Gly Ile Val Leu Ala Asn Ala Cys Gly Pro Cys Ile Gly 
                405                 410                 415     


Gln Trp Asp Arg Arg Asp Ile Lys Lys Gly Glu Lys Asn Thr Ile Val 
            420                 425                 430         


Ser Ser Tyr Asn Arg Asn Phe Thr Gly Arg Asn Asp Ser Asn Pro Ala 
        435                 440                 445             


Thr His Ala Phe Val Thr Ser Pro Asp Leu Val Thr Ala Phe Ala Ile 
    450                 455                 460                 


Ala Gly Asp Leu Arg Phe Asn Pro Leu Thr Asp Ser Leu Lys Asp Ser 
465                 470                 475                 480 


Glu Gly Lys Glu Phe Lys Leu Lys Glu Pro Thr Gly Lys Gly Leu Pro 
                485                 490                 495     


Asp Arg Gly Tyr Asp Pro Gly Met Asp Thr Tyr Gln Ala Pro Pro Ala 
            500                 505                 510         


Asp Arg Ser Ala Val Glu Val Asp Val Ser Pro Thr Ser Asp Arg Leu 
        515                 520                 525             


Gln Ile Leu Lys Pro Phe Lys Pro Trp Asp Gly Lys Asp Gly Ile Asp 
    530                 535                 540                 


Met Pro Ile Leu Ile Lys Ser Leu Gly Lys Thr Thr Thr Asp His Ile 
545                 550                 555                 560 


Ser Gln Ala Gly Pro Trp Leu Lys Tyr Arg Gly His Leu Gln Asn Ile 
                565                 570                 575     


Ser Asn Asn Tyr Met Ile Gly Ala Ile Asn Ala Glu Asn Glu Glu Ala 
            580                 585                 590         


Asn Asn Val Arg Asn Gln Ile Thr Gly Glu Trp Gly Gly Val Pro Glu 
        595                 600                 605             


Thr Ala Ile Ala Tyr Arg Asp Asn Gly Ile Arg Trp Val Val Val Gly 
    610                 615                 620                 


Gly Asp Asn Phe Gly Glu Gly Ser Ser Arg Glu His Ala Ala Leu Glu 
625                 630                 635                 640 


Pro Arg Phe Leu Gly Gly Phe Ala Ile Ile Thr Lys Ser Phe Ala Arg 
                645                 650                 655     


Ile His Glu Thr Asn Leu Lys Lys Gln Gly Leu Leu Pro Leu Asn Phe 
            660                 665                 670         


Val Asn Gly Ala Asp Tyr Asp Lys Ile Gln Pro Ser Asp Lys Ile Ser 
        675                 680                 685             


Ile Leu Gly Leu Lys Asp Leu Ala Pro Gly Lys Asn Val Thr Ile Glu 
    690                 695                 700                 


Val Thr Pro Lys Asp Gly Ala Lys Trp Thr Thr Glu Val Ser His Thr 
705                 710                 715                 720 


Tyr Asn Ser Glu Gln Leu Glu Trp Phe Lys Tyr Gly Ser Ala Leu Asn 
                725                 730                 735     


Lys Met Ala Ala Ser Lys Lys 
            740             


<210>  41
<211>  465
<212>  PRT
<213>  Y. lipolytica

<400>  41

Met Ile Ser Ala Ile Arg Pro Ala Val Arg Ser Ser Val Arg Val Ala 
1               5                   10                  15      


Pro Met Ala Asn Thr Ala Phe Arg Ala Tyr Ser Thr Gln Asp Gly Leu 
            20                  25                  30          


Lys Glu Arg Phe Ala Glu Leu Ile Pro Glu Asn Val Glu Lys Ile Lys 
        35                  40                  45              


Lys Leu Arg Lys Glu Lys Gly Asn Thr Val Ile Gly Glu Val Ile Leu 
    50                  55                  60                  


Asp Gln Ala Tyr Gly Gly Met Arg Gly Ile Lys Gly Leu Val Trp Glu 
65                  70                  75                  80  


Gly Ser Val Leu Asp Pro Glu Glu Gly Ile Arg Phe Arg Gly Leu Thr 
                85                  90                  95      


Ile Pro Asp Leu Gln Lys Gln Leu Pro His Ala Pro Gly Gly Lys Glu 
            100                 105                 110         


Pro Leu Pro Glu Gly Leu Phe Trp Leu Leu Leu Thr Gly Glu Ile Pro 
        115                 120                 125             


Thr Asp Ala Gln Val Lys Gly Leu Ser Ala Asp Trp Ala Ser Arg Ala 
    130                 135                 140                 


Glu Ile Pro Lys His Val Glu Glu Leu Ile Asp Arg Cys Pro Pro Thr 
145                 150                 155                 160 


Leu His Pro Met Ala Gln Leu Gly Ile Ala Val Asn Ala Leu Glu Ser 
                165                 170                 175     


Glu Ser Gln Phe Thr Lys Ala Tyr Glu Lys Gly Val Asn Lys Lys Glu 
            180                 185                 190         


Tyr Trp Gln Tyr Thr Tyr Glu Asp Ser Met Asn Leu Ile Ala Lys Leu 
        195                 200                 205             


Pro Val Ile Ala Ser Arg Ile Tyr Arg Asn Leu Phe Lys Asp Gly Lys 
    210                 215                 220                 


Ile Val Gly Ser Ile Asp Asn Ser Leu Asp Tyr Ser Ala Asn Phe Ala 
225                 230                 235                 240 


Ser Leu Leu Gly Phe Gly Asp Asn Lys Glu Phe Ile Glu Leu Leu Arg 
                245                 250                 255     


Leu Tyr Leu Thr Ile His Ala Asp His Glu Gly Gly Asn Val Ser Ala 
            260                 265                 270         


His Thr Thr Lys Leu Val Gly Ser Ala Leu Ser Ser Pro Phe Leu Ser 
        275                 280                 285             


Leu Ser Ala Gly Leu Asn Gly Leu Ala Gly Pro Leu His Gly Arg Ala 
    290                 295                 300                 


Asn Gln Glu Val Leu Glu Trp Ile Leu Glu Met Lys Ser Lys Ile Gly 
305                 310                 315                 320 


Ser Asp Val Thr Lys Glu Asp Ile Glu Lys Tyr Leu Trp Asp Thr Leu 
                325                 330                 335     


Lys Ala Gly Arg Val Val Pro Gly Tyr Gly His Ala Val Leu Arg Lys 
            340                 345                 350         


Thr Asp Pro Arg Tyr Thr Ala Gln Arg Glu Phe Ala Leu Glu His Met 
        355                 360                 365             


Pro Asp Tyr Asp Leu Phe His Leu Val Ser Thr Ile Tyr Glu Val Ala 
    370                 375                 380                 


Pro Lys Val Leu Thr Glu His Gly Lys Thr Lys Asn Pro Trp Pro Asn 
385                 390                 395                 400 


Val Asp Ser His Ser Gly Val Leu Leu Gln Tyr Tyr Gly Leu Thr Glu 
                405                 410                 415     


Gln Ser Tyr Tyr Thr Val Leu Phe Gly Val Ser Arg Ala Ile Gly Val 
            420                 425                 430         


Leu Pro Gln Leu Ile Met Asp Arg Ala Tyr Gly Ala Pro Ile Glu Arg 
        435                 440                 445             


Pro Lys Ser Phe Ser Thr Glu Lys Tyr Ala Glu Leu Val Gly Leu Lys 
    450                 455                 460                 


Leu 
465 


<210>  42
<211>  436
<212>  PRT
<213>  Y. lipolytica

<400>  42

Met Gly Leu Lys Glu Arg Phe Ala Glu Leu Ile Pro Glu Asn Val Glu 
1               5                   10                  15      


Lys Ile Lys Lys Leu Arg Lys Glu Lys Gly Asn Thr Val Ile Gly Glu 
            20                  25                  30          


Val Ile Leu Asp Gln Ala Tyr Gly Gly Met Arg Gly Ile Lys Gly Leu 
        35                  40                  45              


Val Trp Glu Gly Ser Val Leu Asp Pro Glu Glu Gly Ile Arg Phe Arg 
    50                  55                  60                  


Gly Leu Thr Ile Pro Asp Leu Gln Lys Gln Leu Pro His Ala Pro Gly 
65                  70                  75                  80  


Gly Lys Glu Pro Leu Pro Glu Gly Leu Phe Trp Leu Leu Leu Thr Gly 
                85                  90                  95      


Glu Ile Pro Thr Asp Ala Gln Val Lys Gly Leu Ser Ala Asp Trp Ala 
            100                 105                 110         


Ser Arg Ala Glu Ile Pro Lys His Val Glu Glu Leu Ile Asp Arg Cys 
        115                 120                 125             


Pro Pro Thr Leu His Pro Met Ala Gln Leu Gly Ile Ala Val Asn Ala 
    130                 135                 140                 


Leu Glu Ser Glu Ser Gln Phe Thr Lys Ala Tyr Glu Lys Gly Val Asn 
145                 150                 155                 160 


Lys Lys Glu Tyr Trp Gln Tyr Thr Tyr Glu Asp Ser Met Asn Leu Ile 
                165                 170                 175     


Ala Lys Leu Pro Val Ile Ala Ser Arg Ile Tyr Arg Asn Leu Phe Lys 
            180                 185                 190         


Asp Gly Lys Ile Val Gly Ser Ile Asp Asn Ser Leu Asp Tyr Ser Ala 
        195                 200                 205             


Asn Phe Ala Ser Leu Leu Gly Phe Gly Asp Asn Lys Glu Phe Ile Glu 
    210                 215                 220                 


Leu Leu Arg Leu Tyr Leu Thr Ile His Ala Asp His Glu Gly Gly Asn 
225                 230                 235                 240 


Val Ser Ala His Thr Thr Lys Leu Val Gly Ser Ala Leu Ser Ser Pro 
                245                 250                 255     


Phe Leu Ser Leu Ser Ala Gly Leu Asn Gly Leu Ala Gly Pro Leu His 
            260                 265                 270         


Gly Arg Ala Asn Gln Glu Val Leu Glu Trp Ile Leu Glu Met Lys Ser 
        275                 280                 285             


Lys Ile Gly Ser Asp Val Thr Lys Glu Asp Ile Glu Lys Tyr Leu Trp 
    290                 295                 300                 


Asp Thr Leu Lys Ala Gly Arg Val Val Pro Gly Tyr Gly His Ala Val 
305                 310                 315                 320 


Leu Arg Lys Thr Asp Pro Arg Tyr Thr Ala Gln Arg Glu Phe Ala Leu 
                325                 330                 335     


Glu His Met Pro Asp Tyr Asp Leu Phe His Leu Val Ser Thr Ile Tyr 
            340                 345                 350         


Glu Val Ala Pro Lys Val Leu Thr Glu His Gly Lys Thr Lys Asn Pro 
        355                 360                 365             


Trp Pro Asn Val Asp Ser His Ser Gly Val Leu Leu Gln Tyr Tyr Gly 
    370                 375                 380                 


Leu Thr Glu Gln Ser Tyr Tyr Thr Val Leu Phe Gly Val Ser Arg Ala 
385                 390                 395                 400 


Ile Gly Val Leu Pro Gln Leu Ile Met Asp Arg Ala Tyr Gly Ala Pro 
                405                 410                 415     


Ile Glu Arg Pro Lys Ser Phe Ser Thr Glu Lys Tyr Ala Glu Leu Val 
            420                 425                 430         


Gly Leu Lys Leu 
        435     


<210>  43
<211>  516
<212>  PRT
<213>  Y. lipolytica

<400>  43

Met Arg Ala Leu Leu Asn Lys Ala Asp Glu Thr Phe Ala Ser Thr Gly 
1               5                   10                  15      


Gly Ser Ile Asp Ile Glu Leu Asp Ser Ile Asp Gln Lys Leu Pro Arg 
            20                  25                  30          


Val Ser Val Ser Ser Asp Leu Gly Ser Gly Ser Asp Thr Ala Gly Glu 
        35                  40                  45              


Gly Asp Gly Pro Val Ser Ala Asn Thr Asp Asp Ser Asn Thr Asn Thr 
    50                  55                  60                  


Leu Asp Val Glu Ala Leu Pro Ala Thr Ala Pro Asp Asp Asp Val Lys 
65                  70                  75                  80  


Phe Asn Arg Phe Thr Leu Ser Gln Lys Arg Ile Met Thr Ala Val Leu 
                85                  90                  95      


Ala Phe Cys Phe Phe Gln Pro Phe Leu Val Thr Tyr Ala Met Leu Pro 
            100                 105                 110         


Ala Val Pro Leu Ile Ala Glu Gln Phe Asp Val Ser Gly Thr Ile Val 
        115                 120                 125             


Thr Val Gly Asn Ala Ile Phe Phe Leu Ile Thr Gly Phe Ser Ser Cys 
    130                 135                 140                 


Phe Phe Gly Pro Phe Ser Asp Ala Tyr Gly Arg Lys Ala Ala Leu Ile 
145                 150                 155                 160 


Thr Cys Cys Ile Ile Phe Ile Val Ser Asn Ile Gly Ile Ala Ala Ser 
                165                 170                 175     


Pro Asn Leu Val Ser Tyr Tyr Ile Phe Arg Ala Thr Thr Ala Met Gly 
            180                 185                 190         


Gly Thr Ala Phe Phe Ser Val Ser Gly Ser Ala Ile Ala Asp Ile Trp 
        195                 200                 205             


Arg Pro Glu His Arg Gly Lys Ala Val Gly Ala Cys Leu Leu Gly Ser 
    210                 215                 220                 


Gln Ser Gly Met Thr Ile Gly Pro Ile Ile Gly Gly Trp Ile Val Thr 
225                 230                 235                 240 


Lys Thr Ser Trp Arg Val Ile Phe Trp Met Gln Ala Gly Val Ala Leu 
                245                 250                 255     


Ala Asn Leu Leu Leu Val Thr Phe Val Leu Arg Glu Pro Met Ala Thr 
            260                 265                 270         


Thr Lys His Gln Met Leu Cys Ala Glu Gln Asn Lys Arg Phe Val Trp 
        275                 280                 285             


Ile Trp Ile Asn Pro Phe Lys Val Leu Met Gly Leu Arg Asn Met His 
    290                 295                 300                 


Leu Leu Leu Ala Gly Leu Ser Ile Val Pro Ile Met Tyr Gly Met Asp 
305                 310                 315                 320 


Cys Leu Leu Thr Pro Leu Ser Leu Val Val Glu Pro Arg Phe Asp Ile 
                325                 330                 335     


Lys Ser Pro Val Val Ala Ala Leu Phe Tyr Leu Pro Gln Gly Val Gly 
            340                 345                 350         


Phe Leu Ile Gly Cys Tyr Phe Gly Gly Met Tyr Ala Asp Lys Thr Val 
        355                 360                 365             


Gln Arg Trp Thr Lys Ile Arg Gly Arg Arg Val Cys Glu Asp Arg Leu 
    370                 375                 380                 


Arg Ser Gln Leu Pro Phe Val Gly Ile Leu Leu Pro Val Cys Met Leu 
385                 390                 395                 400 


Ile Tyr Gly Trp Ser Leu Glu Lys Glu Phe Gly Gly Val Ala Val Pro 
                405                 410                 415     


Val Val Thr Met Phe Leu Val Gly Phe Gly Leu Ser Met Tyr Phe Pro 
            420                 425                 430         


Ser Leu Asn Ala Tyr Cys Ala Asp Ser Ser Pro Glu Leu Gly Thr Ala 
        435                 440                 445             


Ala Ala Ile Ser Gly Asn Tyr Ala Ile Arg Asn Cys Gly Ser Ala Ile 
    450                 455                 460                 


Ala Ala Ala Ser Thr Leu Lys Ala Val Glu Asn Ile Gly Ile Gly Trp 
465                 470                 475                 480 


Thr Ser Thr Val Ala Ala Phe Gly Phe Ile Ala Ser Thr Ile Pro Val 
                485                 490                 495     


Phe Ile Leu Leu Trp Lys Gly Glu Asp Met Arg Gln Lys Ala Val Arg 
            500                 505                 510         


Arg Met Met Arg 
        515     


<210>  44
<211>  292
<212>  PRT
<213>  Y. lipolytica

<400>  44

Met Val Ser Ser Asp Thr Lys Lys Ala Glu Pro Trp Lys Ser Leu Val 
1               5                   10                  15      


Ala Gly Ser Thr Ala Gly Ala Val Glu Gly Leu Val Thr Tyr Pro Phe 
            20                  25                  30          


Glu Trp Ser Lys Thr Arg Leu Gln Leu Val Asp Lys Ser Ser Thr Ala 
        35                  40                  45              


Ser Arg Asn Pro Leu Val Leu Ile Tyr Asn Thr Ala Lys Thr Gln Gly 
    50                  55                  60                  


Leu Gly Ala Val Tyr Thr Gly Cys Pro Ala Phe Ile Val Gly Asn Thr 
65                  70                  75                  80  


Val Lys Ala Gly Val Arg Phe Leu Gly Phe Asp Ala Ile Lys Gly Leu 
                85                  90                  95      


Leu Ala Asp Lys Asp Gly Lys Val Ser Gly Pro Arg Gly Val Leu Ala 
            100                 105                 110         


Gly Leu Gly Ala Gly Val Leu Glu Ser Val Val Ala Val Thr Pro Phe 
        115                 120                 125             


Glu Thr Ile Lys Thr Ala Met Ile Asp Asp Arg Gln Ser Lys Asn Pro 
    130                 135                 140                 


Lys Tyr Gln Gly Leu Phe Lys Gly Thr Ala Gln Leu Ile Lys Asp Lys 
145                 150                 155                 160 


Gly Leu Ser Gly Ile Tyr Arg Gly Leu Val Pro Val Thr Met Arg Gln 
                165                 170                 175     


Ala Ala Asn Gln Ala Val Arg Leu Gly Ser Tyr Asn Trp Met Lys Val 
            180                 185                 190         


Phe Ile Gln Ser Arg Gln Lys Asp Pro Lys Ala Pro Leu Ser Ser Leu 
        195                 200                 205             


Ser Thr Phe Ile Val Gly Ala Phe Ala Gly Ile Val Thr Val Tyr Thr 
    210                 215                 220                 


Thr Met Pro Leu Asp Thr Val Lys Thr Arg Met Gln Ser Leu Glu Ala 
225                 230                 235                 240 


Lys Lys Glu Tyr Arg Gly Thr Phe His Cys Phe Ala Arg Ile Phe Lys 
                245                 250                 255     


Glu Glu Gly Leu Leu Thr Phe Trp Lys Gly Ala Thr Pro Arg Leu Gly 
            260                 265                 270         


Arg Leu Ile Leu Ser Gly Gly Ile Val Phe Thr Ile Tyr Glu Lys Ile 
        275                 280                 285             


Met Glu Ile Leu 
    290         


<210>  45
<211>  953
<212>  PRT
<213>  Y. lipolytica

<400>  45

Met Ile Glu Gly Ile Ser Phe Ala Ser Phe Val Thr His Glu Lys Pro 
1               5                   10                  15      


Lys Phe Val Arg Ala Leu Asp Phe Tyr Lys Ala Leu Gly Phe Leu Pro 
            20                  25                  30          


Thr Lys Glu Tyr Lys His Gly Thr Asp His His Ala Thr Asp Glu Glu 
        35                  40                  45              


Gly Ala Gly Ser Ile Gln Glu Val Trp Leu Thr Ser Ser Arg Ala Gly 
    50                  55                  60                  


Val Pro Ser Val Thr Val Lys Leu Arg Leu Ser Arg His Gly Asn Glu 
65                  70                  75                  80  


His Val Ser Leu Pro Asn Leu Lys His Asp Trp Arg Ser Leu Val Pro 
                85                  90                  95      


Ser Leu Val Tyr Tyr Ala Pro Asp Leu Asp Ala Val Arg Ala Ala Ile 
            100                 105                 110         


Thr Pro Phe Leu His Glu Asp His Ser Thr Leu Leu Glu Arg Pro Ser 
        115                 120                 125             


His Thr Asn Phe Ile Glu Leu Tyr Ala Ile Asp Pro Met Gly Asn Leu 
    130                 135                 140                 


Val Gly Phe Ser Arg Arg Glu Asn Pro Tyr Ser Ser Ala Met Gln Lys 
145                 150                 155                 160 


Pro Phe Ser Ala Asp Asp Ile Gly Pro Gln Asn Phe Ser Lys Pro Asn 
                165                 170                 175     


Glu Thr Lys Ile Lys Gly Lys Lys Arg Ile Gly Val Met Thr Ser Gly 
            180                 185                 190         


Gly Asp Ala Pro Gly Met Cys Ala Ala Val Arg Ala Val Val Arg Ala 
        195                 200                 205             


Gly Ile Ala Arg Gly Cys Glu Val Tyr Ala Val Arg Glu Gly Tyr Glu 
    210                 215                 220                 


Gly Leu Val Lys Gly Gly Asp Leu Ile Glu Pro Leu Ser Trp Glu Asp 
225                 230                 235                 240 


Val Arg Gly Trp Leu Ser Leu Gly Gly Thr Leu Ile Gly Thr Ala Arg 
                245                 250                 255     


Cys Lys Glu Phe Arg Glu Arg Glu Gly Arg Leu Ala Gly Ala Leu Asn 
            260                 265                 270         


Met Val Lys Asn Gly Ile Asp Ala Leu Ile Val Ile Gly Gly Asp Gly 
        275                 280                 285             


Ser Leu Thr Gly Ala Asp Leu Phe Arg Glu Glu Trp Pro Ser Leu Ile 
    290                 295                 300                 


Glu Glu Leu Val Thr Asn Gly Ser Ile Thr Ala Glu Gln Ala Glu Arg 
305                 310                 315                 320 


His Arg His Leu Asp Ile Cys Gly Met Val Gly Ser Ile Asp Asn Asp 
                325                 330                 335     


Met Ala Thr Thr Asp Val Thr Ile Gly Ala Tyr Ser Ser Leu Asp Arg 
            340                 345                 350         


Ile Cys Glu Leu Val Asp Phe Ile Asp Ala Thr Ala Gln Ser His Ser 
        355                 360                 365             


Arg Ala Phe Val Val Glu Val Met Gly Arg His Cys Gly Trp Leu Ala 
    370                 375                 380                 


Leu Met Ala Gly Thr Ala Thr Gly Ala Asp Tyr Ile Phe Ile Pro Glu 
385                 390                 395                 400 


Ala Ala Pro Asp Ala Thr Gln Trp Ala Glu Lys Met Thr Arg Val Val 
                405                 410                 415     


Lys Arg His Arg Ser Gln Gly Lys Arg Lys Thr Val Val Ile Val Ala 
            420                 425                 430         


Glu Gly Ala Ile Asp Ser Asp Leu Asn Pro Ile Thr Ala Lys Met Val 
        435                 440                 445             


Lys Asp Val Leu Asp Gly Ile Gly Leu Asp Thr Arg Ile Ser Thr Leu 
    450                 455                 460                 


Gly His Val Gln Arg Gly Gly Pro Pro Val Ala Ala Asp Arg Val Leu 
465                 470                 475                 480 


Ala Ser Leu Gln Gly Val Glu Ala Ile Asp Ala Ile Leu Ser Leu Thr 
                485                 490                 495     


Pro Glu Thr Pro Ser Pro Met Ile Ala Leu Asn Glu Asn Lys Ile Thr 
            500                 505                 510         


Arg Lys Pro Leu Val Glu Ser Val Ala Leu Thr Lys Lys Val Ala Asp 
        515                 520                 525             


Ala Ile Gly Asn Lys Asp Phe Ala Glu Ala Met Arg Leu Arg Asn Pro 
    530                 535                 540                 


Glu Phe Val Glu Gln Leu Gln Gly Phe Leu Leu Thr Asn Ser Ala Asp 
545                 550                 555                 560 


Lys Asp Arg Pro Gln Glu Pro Ala Lys Asp Pro Leu Arg Val Ala Ile 
                565                 570                 575     


Val Cys Thr Gly Ala Pro Ala Gly Gly Met Asn Ala Ala Ile Arg Ser 
            580                 585                 590         


Ala Val Leu Tyr Gly Leu Ala Arg Gly His Gln Met Phe Ala Ile His 
        595                 600                 605             


Asn Gly Trp Ser Gly Leu Val Lys Asn Gly Asp Asp Ala Val Arg Glu 
    610                 615                 620                 


Leu Thr Trp Leu Glu Val Glu Pro Leu Cys Gln Lys Gly Gly Cys Glu 
625                 630                 635                 640 


Ile Gly Thr Asn Arg Ser Leu Pro Glu Cys Asp Leu Gly Met Ile Ala 
                645                 650                 655     


Tyr His Phe Gln Arg Gln Arg Phe Asp Gly Leu Ile Val Ile Gly Gly 
            660                 665                 670         


Phe Glu Ala Phe Arg Ala Leu Asn Gln Leu Asp Asp Ala Arg His Ala 
        675                 680                 685             


Tyr Pro Ala Leu Arg Ile Pro Met Val Gly Ile Pro Ala Thr Ile Ser 
    690                 695                 700                 


Asn Asn Val Pro Gly Thr Asp Tyr Ser Leu Gly Ala Asp Thr Cys Leu 
705                 710                 715                 720 


Asn Ser Leu Val Gln Tyr Cys Asp Val Leu Lys Thr Ser Ala Ser Ala 
                725                 730                 735     


Thr Arg Leu Arg Leu Phe Val Val Glu Val Gln Gly Gly Asn Ser Gly 
            740                 745                 750         


Tyr Ile Ala Thr Val Ala Gly Leu Ile Thr Gly Ala Tyr Val Val Tyr 
        755                 760                 765             


Thr Pro Glu Ser Gly Ile Asn Leu Arg Leu Leu Gln His Asp Ile Ser 
    770                 775                 780                 


Tyr Leu Lys Asp Thr Phe Ala His Gln Ala Asp Val Asn Arg Thr Gly 
785                 790                 795                 800 


Lys Leu Leu Leu Arg Asn Glu Arg Ser Ser Asn Val Phe Thr Thr Asp 
                805                 810                 815     


Val Ile Thr Gly Ile Ile Asn Glu Glu Ala Lys Gly Ser Phe Asp Ala 
            820                 825                 830         


Arg Thr Ala Ile Pro Gly His Val Gln Gln Gly Gly His Pro Ser Pro 
        835                 840                 845             


Thr Asp Arg Val Arg Ala Gln Arg Phe Ala Ile Lys Ala Val Gln Phe 
    850                 855                 860                 


Ile Glu Glu His His Gly Ser Lys Asn Asn Ala Asp His Cys Val Ile 
865                 870                 875                 880 


Leu Gly Val Arg Gly Ser Lys Phe Lys Tyr Thr Ser Val Ser His Leu 
                885                 890                 895     


Tyr Ala His Lys Thr Glu His Gly Ala Arg Arg Pro Lys His Ser Tyr 
            900                 905                 910         


Trp His Ala Ile Gly Asp Ile Ala Asn Met Leu Val Gly Arg Lys Ala 
        915                 920                 925             


Pro Pro Leu Pro Glu Thr Leu Asn Asp Glu Ile Glu Lys Asn Ile Ala 
    930                 935                 940                 


Lys Glu Gln Gly Ile Ile Asp Pro Cys 
945                 950             


<210>  46
<211>  953
<212>  PRT
<213>  Y. lipolytica

<400>  46

Met Ile Glu Gly Ile Ser Phe Ala Ser Phe Val Thr His Glu Lys Pro 
1               5                   10                  15      


Lys Phe Val Arg Ala Leu Asp Phe Tyr Lys Ala Leu Gly Phe Leu Pro 
            20                  25                  30          


Thr Lys Glu Tyr Lys His Gly Thr Asp His His Ala Thr Asp Glu Glu 
        35                  40                  45              


Gly Ala Gly Ser Ile Gln Glu Val Trp Leu Thr Ser Ser Arg Ala Gly 
    50                  55                  60                  


Val Pro Ser Val Thr Val Lys Leu Arg Leu Ser Arg His Gly Asn Glu 
65                  70                  75                  80  


His Val Ser Leu Pro Asn Leu Lys His Asp Trp Arg Ser Leu Val Pro 
                85                  90                  95      


Ser Leu Val Tyr Tyr Ala Pro Asp Leu Asp Ala Val Arg Ala Ala Ile 
            100                 105                 110         


Thr Pro Phe Leu His Glu Asp His Ser Thr Leu Leu Glu Arg Pro Ser 
        115                 120                 125             


His Thr Asn Phe Ile Glu Leu Tyr Ala Ile Asp Pro Met Gly Asn Leu 
    130                 135                 140                 


Val Gly Phe Ser Arg Arg Glu Asn Pro Tyr Ser Ser Ala Met Gln Lys 
145                 150                 155                 160 


Pro Phe Ser Ala Asp Asp Ile Gly Pro Gln Asn Phe Ser Lys Pro Asn 
                165                 170                 175     


Glu Thr Lys Ile Lys Gly Lys Lys Arg Ile Gly Val Met Thr Ser Gly 
            180                 185                 190         


Gly Asp Ala Pro Gly Met Cys Ala Ala Val Arg Ala Val Val Arg Ala 
        195                 200                 205             


Gly Ile Ala Arg Gly Cys Glu Val Tyr Ala Val Arg Glu Gly Tyr Glu 
    210                 215                 220                 


Gly Leu Val Lys Gly Gly Asp Leu Ile Glu Pro Leu Ser Trp Glu Asp 
225                 230                 235                 240 


Val Arg Gly Trp Leu Ser Leu Gly Gly Thr Leu Ile Gly Thr Ala Arg 
                245                 250                 255     


Cys Lys Glu Phe Arg Glu Arg Glu Gly Arg Leu Ala Gly Ala Leu Asn 
            260                 265                 270         


Met Val Lys Asn Gly Ile Asp Ala Leu Ile Val Ile Gly Gly Asp Gly 
        275                 280                 285             


Ser Leu Thr Gly Ala Asp Leu Phe Arg Glu Glu Trp Pro Ser Leu Ile 
    290                 295                 300                 


Glu Glu Leu Val Thr Asn Gly Ser Ile Thr Ala Glu Gln Ala Glu Arg 
305                 310                 315                 320 


His Arg His Leu Asp Ile Cys Gly Met Val Gly Ser Ile Asp Asn Asp 
                325                 330                 335     


Met Ala Thr Thr Asp Val Thr Ile Gly Ala Tyr Ser Ser Leu Asp Arg 
            340                 345                 350         


Ile Cys Glu Leu Val Asp Phe Ile Asp Ala Thr Ala Gln Ser His Ser 
        355                 360                 365             


Arg Ala Phe Val Val Glu Val Met Gly Arg His Cys Gly Trp Leu Ala 
    370                 375                 380                 


Leu Met Ala Gly Thr Ala Thr Gly Ala Asp Tyr Ile Phe Ile Pro Glu 
385                 390                 395                 400 


Ala Ala Pro Asp Ala Thr Gln Trp Ala Glu Lys Met Thr Arg Val Val 
                405                 410                 415     


Lys Arg His Arg Ser Gln Gly Lys Arg Lys Thr Val Val Ile Val Ala 
            420                 425                 430         


Glu Gly Ala Ile Asp Ser Asp Leu Asn Pro Ile Thr Ala Lys Met Val 
        435                 440                 445             


Lys Asp Val Leu Asp Gly Ile Gly Leu Asp Thr Arg Ile Ser Thr Leu 
    450                 455                 460                 


Gly His Val Gln Arg Gly Gly Pro Pro Val Ala Ala Asp Arg Val Leu 
465                 470                 475                 480 


Ala Ser Leu Gln Gly Val Glu Ala Ile Asp Ala Ile Leu Ser Leu Thr 
                485                 490                 495     


Pro Glu Thr Pro Ser Pro Met Ile Ala Leu Asn Glu Asn Lys Ile Thr 
            500                 505                 510         


Arg Lys Pro Leu Val Glu Ser Val Ala Leu Thr Lys Lys Val Ala Asp 
        515                 520                 525             


Ala Ile Gly Asn Lys Asp Phe Ala Glu Ala Met Arg Leu Arg Asn Pro 
    530                 535                 540                 


Glu Phe Val Glu Gln Leu Gln Gly Phe Leu Leu Thr Asn Ser Ala Asp 
545                 550                 555                 560 


Lys Asp Arg Pro Gln Glu Pro Ala Lys Asp Pro Leu Arg Val Ala Ile 
                565                 570                 575     


Val Cys Thr Gly Ala Pro Ala Gly Gly Met Asn Ala Ala Ile Arg Ser 
            580                 585                 590         


Ala Val Leu Tyr Gly Leu Ala Arg Gly His Gln Met Phe Ala Ile His 
        595                 600                 605             


Asn Gly Trp Ser Gly Leu Val Lys Asn Gly Asp Asp Ala Val Arg Glu 
    610                 615                 620                 


Leu Thr Trp Leu Glu Val Glu Pro Leu Cys Gln Lys Gly Gly Cys Glu 
625                 630                 635                 640 


Ile Gly Thr Asn Arg Ser Leu Pro Glu Cys Asp Leu Gly Met Ile Ala 
                645                 650                 655     


Tyr His Phe Gln Arg Gln Arg Phe Asp Gly Leu Ile Val Ile Gly Gly 
            660                 665                 670         


Phe Glu Ala Phe Arg Ala Leu Asn Gln Leu Asp Asp Ala Arg His Ala 
        675                 680                 685             


Tyr Pro Ala Leu Arg Ile Pro Met Val Gly Ile Pro Ala Thr Ile Ser 
    690                 695                 700                 


Asn Asn Val Pro Gly Thr Asp Tyr Ser Leu Gly Ala Asp Thr Cys Leu 
705                 710                 715                 720 


Asn Ser Leu Val Gln Tyr Cys Asp Val Leu Ala Thr Ser Ala Ser Ala 
                725                 730                 735     


Thr Arg Leu Arg Leu Phe Val Val Glu Val Gln Gly Gly Asn Ser Gly 
            740                 745                 750         


Tyr Ile Ala Thr Val Ala Gly Leu Ile Thr Gly Ala Tyr Val Val Tyr 
        755                 760                 765             


Thr Pro Glu Ser Gly Ile Asn Leu Arg Leu Leu Gln His Asp Ile Ser 
    770                 775                 780                 


Tyr Leu Lys Asp Thr Phe Ala His Gln Ala Asp Val Asn Arg Thr Gly 
785                 790                 795                 800 


Lys Leu Leu Leu Arg Asn Glu Arg Ser Ser Asn Val Phe Thr Thr Asp 
                805                 810                 815     


Val Ile Thr Gly Ile Ile Asn Glu Glu Ala Lys Gly Ser Phe Asp Ala 
            820                 825                 830         


Arg Thr Ala Ile Pro Gly His Val Gln Gln Gly Gly His Pro Ser Pro 
        835                 840                 845             


Thr Asp Arg Val Arg Ala Gln Arg Phe Ala Ile Lys Ala Val Gln Phe 
    850                 855                 860                 


Ile Glu Glu His His Gly Ser Lys Asn Asn Ala Asp His Cys Val Ile 
865                 870                 875                 880 


Leu Gly Val Arg Gly Ser Lys Phe Lys Tyr Thr Ser Val Ser His Leu 
                885                 890                 895     


Tyr Ala His Lys Thr Glu His Gly Ala Arg Arg Pro Lys His Ser Tyr 
            900                 905                 910         


Trp His Ala Ile Gly Asp Ile Ala Asn Met Leu Val Gly Arg Lys Ala 
        915                 920                 925             


Pro Pro Leu Pro Glu Thr Leu Asn Asp Glu Ile Glu Lys Asn Ile Ala 
    930                 935                 940                 


Lys Glu Gln Gly Ile Ile Asp Pro Cys 
945                 950             


<210>  47
<211>  953
<212>  PRT
<213>  Y. lipolytica

<400>  47

Met Ile Glu Gly Ile Ser Phe Ala Ser Phe Val Thr His Glu Lys Pro 
1               5                   10                  15      


Lys Phe Val Arg Ala Leu Asp Phe Tyr Lys Ala Leu Gly Phe Leu Pro 
            20                  25                  30          


Thr Lys Glu Tyr Lys His Gly Thr Asp His His Ala Thr Asp Glu Glu 
        35                  40                  45              


Gly Ala Gly Ser Ile Gln Glu Val Trp Leu Thr Ser Ser Arg Ala Gly 
    50                  55                  60                  


Val Pro Ser Val Thr Val Lys Leu Arg Leu Ser Arg His Gly Asn Glu 
65                  70                  75                  80  


His Val Ser Leu Pro Asn Leu Lys His Asp Trp Arg Ser Leu Val Pro 
                85                  90                  95      


Ser Leu Val Tyr Tyr Ala Pro Asp Leu Asp Ala Val Arg Ala Ala Ile 
            100                 105                 110         


Thr Pro Phe Leu His Glu Asp His Ser Thr Leu Leu Glu Arg Pro Ser 
        115                 120                 125             


His Thr Asn Phe Ile Glu Leu Tyr Ala Ile Asp Pro Met Gly Asn Leu 
    130                 135                 140                 


Val Gly Phe Ser Arg Arg Glu Asn Pro Tyr Ser Ser Ala Met Gln Lys 
145                 150                 155                 160 


Pro Phe Ser Ala Asp Asp Ile Gly Pro Gln Asn Phe Ser Lys Pro Asn 
                165                 170                 175     


Glu Thr Lys Ile Lys Gly Lys Lys Arg Ile Gly Val Met Thr Ser Gly 
            180                 185                 190         


Gly Asp Ala Pro Gly Met Cys Ala Ala Val Arg Ala Val Val Arg Ala 
        195                 200                 205             


Gly Ile Ala Arg Gly Cys Glu Val Tyr Ala Val Arg Glu Gly Tyr Glu 
    210                 215                 220                 


Gly Leu Val Lys Gly Gly Asp Leu Ile Glu Pro Leu Ser Trp Glu Asp 
225                 230                 235                 240 


Val Arg Gly Trp Leu Ser Leu Gly Gly Thr Leu Ile Gly Thr Ala Arg 
                245                 250                 255     


Cys Lys Glu Phe Arg Glu Arg Glu Gly Arg Leu Ala Gly Ala Leu Asn 
            260                 265                 270         


Met Val Lys Asn Gly Ile Asp Ala Leu Ile Val Ile Gly Gly Asp Gly 
        275                 280                 285             


Ser Leu Thr Gly Ala Asp Leu Phe Arg Glu Glu Trp Pro Ser Leu Ile 
    290                 295                 300                 


Glu Glu Leu Val Thr Asn Gly Ser Ile Thr Ala Glu Gln Ala Glu Arg 
305                 310                 315                 320 


His Arg His Leu Asp Ile Cys Gly Met Val Gly Ser Ile Asp Asn Asp 
                325                 330                 335     


Met Ala Thr Thr Asp Val Thr Ile Gly Ala Tyr Ser Ser Leu Asp Arg 
            340                 345                 350         


Ile Cys Glu Leu Val Asp Phe Ile Asp Ala Thr Ala Gln Ser His Ser 
        355                 360                 365             


Arg Ala Phe Val Val Glu Val Met Gly Arg His Cys Gly Trp Leu Ala 
    370                 375                 380                 


Leu Met Ala Gly Thr Ala Thr Gly Ala Asp Tyr Ile Phe Ile Pro Glu 
385                 390                 395                 400 


Ala Ala Pro Asp Ala Thr Gln Trp Ala Glu Lys Met Thr Arg Val Val 
                405                 410                 415     


Lys Arg His Arg Ser Gln Gly Lys Arg Lys Thr Val Val Ile Val Ala 
            420                 425                 430         


Glu Gly Ala Ile Asp Ser Asp Leu Asn Pro Ile Thr Ala Lys Met Val 
        435                 440                 445             


Lys Asp Val Leu Asp Gly Ile Gly Leu Asp Thr Arg Ile Ser Thr Leu 
    450                 455                 460                 


Gly His Val Gln Arg Gly Gly Pro Pro Val Ala Ala Asp Arg Val Leu 
465                 470                 475                 480 


Ala Ser Leu Gln Gly Val Glu Ala Ile Asp Ala Ile Leu Ser Leu Thr 
                485                 490                 495     


Pro Glu Thr Pro Ser Pro Met Ile Ala Leu Asn Glu Asn Lys Ile Thr 
            500                 505                 510         


Arg Lys Pro Leu Val Glu Ser Val Ala Leu Thr Lys Lys Val Ala Asp 
        515                 520                 525             


Ala Ile Gly Asn Lys Asp Phe Ala Glu Ala Met Arg Leu Arg Asn Pro 
    530                 535                 540                 


Glu Phe Val Glu Gln Leu Gln Gly Phe Leu Leu Thr Asn Ser Ala Asp 
545                 550                 555                 560 


Lys Asp Arg Pro Gln Glu Pro Ala Lys Asp Pro Leu Arg Val Ala Ile 
                565                 570                 575     


Val Cys Thr Gly Ala Pro Ala Gly Gly Met Asn Ala Ala Ile Arg Ser 
            580                 585                 590         


Ala Val Leu Tyr Gly Leu Ala Arg Gly His Gln Met Phe Ala Ile His 
        595                 600                 605             


Asn Gly Trp Ser Gly Leu Val Lys Asn Gly Asp Asp Ala Val Arg Glu 
    610                 615                 620                 


Leu Thr Trp Leu Glu Val Glu Pro Leu Cys Gln Lys Gly Gly Cys Glu 
625                 630                 635                 640 


Ile Gly Thr Asn Arg Ser Leu Pro Glu Cys Asp Leu Gly Met Ile Ala 
                645                 650                 655     


Tyr His Phe Gln Arg Gln Arg Phe Asp Gly Leu Ile Val Ile Gly Gly 
            660                 665                 670         


Phe Glu Ala Phe Arg Ala Leu Asn Gln Leu Asp Asp Ala Arg His Ala 
        675                 680                 685             


Tyr Pro Ala Leu Arg Ile Pro Met Val Gly Ile Pro Ala Thr Ile Ser 
    690                 695                 700                 


Asn Asn Val Pro Gly Thr Asp Tyr Ser Leu Gly Ala Asp Thr Cys Leu 
705                 710                 715                 720 


Asn Ser Leu Val Gln Tyr Cys Asp Val Leu Arg Thr Ser Ala Ser Ala 
                725                 730                 735     


Thr Arg Leu Arg Leu Phe Val Val Glu Val Gln Gly Gly Asn Ser Gly 
            740                 745                 750         


Tyr Ile Ala Thr Val Ala Gly Leu Ile Thr Gly Ala Tyr Val Val Tyr 
        755                 760                 765             


Thr Pro Glu Ser Gly Ile Asn Leu Arg Leu Leu Gln His Asp Ile Ser 
    770                 775                 780                 


Tyr Leu Lys Asp Thr Phe Ala His Gln Ala Asp Val Asn Arg Thr Gly 
785                 790                 795                 800 


Lys Leu Leu Leu Arg Asn Glu Arg Ser Ser Asn Val Phe Thr Thr Asp 
                805                 810                 815     


Val Ile Thr Gly Ile Ile Asn Glu Glu Ala Lys Gly Ser Phe Asp Ala 
            820                 825                 830         


Arg Thr Ala Ile Pro Gly His Val Gln Gln Gly Gly His Pro Ser Pro 
        835                 840                 845             


Thr Asp Arg Val Arg Ala Gln Arg Phe Ala Ile Lys Ala Val Gln Phe 
    850                 855                 860                 


Ile Glu Glu His His Gly Ser Lys Asn Asn Ala Asp His Cys Val Ile 
865                 870                 875                 880 


Leu Gly Val Arg Gly Ser Lys Phe Lys Tyr Thr Ser Val Ser His Leu 
                885                 890                 895     


Tyr Ala His Lys Thr Glu His Gly Ala Arg Arg Pro Lys His Ser Tyr 
            900                 905                 910         


Trp His Ala Ile Gly Asp Ile Ala Asn Met Leu Val Gly Arg Lys Ala 
        915                 920                 925             


Pro Pro Leu Pro Glu Thr Leu Asn Asp Glu Ile Glu Lys Asn Ile Ala 
    930                 935                 940                 


Lys Glu Gln Gly Ile Ile Asp Pro Cys 
945                 950             


