               SEQUENCE LISTING

<110> Silence Therapeutics GmbH

<120> Means for inhibiting the expression of EDN1

<130> P6866WO1

<150> EP14004030.4
<151> 2014-11-28

<160> 45

<170> BiSSAP 1.2

<210> 1
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 1
uuucaauuug ugcauuccu                                                 19


<210> 2
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 2
aggaaugcac aaauugaaa                                                 19


<210> 3
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 3
auacauagac caauauggc                                                 19


<210> 4
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 4
gccauauugg ucuauguau                                                 19


<210> 5
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 5
uguuucugga gcuccuugg                                                 19


<210> 6
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 6
ccaaggagcu ccagaaaca                                                 19


<210> 7
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 7
uggacuuugg aguuucucc                                                 19


<210> 8
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 8
ggagaaacuc caaagucca                                                 19


<210> 9
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<220> 
<221> misc_feature
<222> 1,3,5,7,9,11,13,15,17,19
<223> /note="2'OMe modification"

<400> 9
auauuuaaca ugguaaaua                                                 19


<210> 10
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 10
uauuuaccau guuaaauau                                                 19


<210> 11
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 11
aaaauauuua uuuucuaaa                                                 19


<210> 12
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 12
uuuagaaaau aaauauuuu                                                 19


<210> 13
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 13
aaauuccagc acuucuugu                                                 19


<210> 14
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 14
acaagaagug cuggaauuu                                                 19


<210> 15
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 15
auguccaggu ggcagaagu                                                 19


<210> 16
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 16
acuucugcca ccuggacau                                                 19


<210> 17
<211> 2112
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..2112
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> misc_feature
<222> 1..2112
<223> /note="mRNA coding for EDN1"

<400> 17
ggagcuguuu acccccacuc uaauaggggu ucaauauaaa aagccggcag agagcugucc      60

aagucagacg cgccucugca ucugcgccag gcgaacgggu ccugcgccuc cugcaguccc     120

agcucuccac cgccgcgugc gccugcagac gcuccgcucg cugccuucuc uccuggcagg     180

cgcugccuuu ucuccccguu aaaagggcac uugggcugaa ggaucgcuuu gagaucugag     240

gaacccgcag cgcuuugagg gaccugaagc uguuuuucuu cguuuuccuu uggguucagu     300

uugaacggga gguuuuugau cccuuuuuuu cagaauggau uauuugcuca ugauuuucuc     360

ucugcuguuu guggcuugcc aaggagcucc agaaacagca gucuuaggcg cugagcucag     420

cgcggugggu gagaacggcg gggagaaacc cacucccagu ccacccuggc ggcuccgccg     480

guccaagcgc ugcuccugcu cgucccugau ggauaaagag ugugucuacu ucugccaccu     540

ggacaucauu ugggucaaca cucccgagca cguuguuccg uauggacuug gaagcccuag     600

guccaagaga gccuuggaga auuuacuucc cacaaaggca acagaccgug aaaauagaug     660

ccaaugugcu agccaaaaag acaagaagug cuggaauuuu ugccaagcag gaaaagaacu     720

cagggcugaa gacauuaugg agaaagacug gaauaaucau aagaaaggaa aagacuguuc     780

caagcuuggg aaaaagugua uuuaucagca guuagugaga ggaagaaaaa ucagaagaag     840

uucagaggaa caccuaagac aaaccagguc ggagaccaug agaaacagcg ucaaaucauc     900

uuuucaugau cccaagcuga aaggcaagcc cuccagagag cguuauguga cccacaaccg     960

agcacauugg ugacagaccu ucggggccug ucugaagcca uagccuccac ggagagcccu    1020

guggccgacu cugcacucuc cacccuggcu gggaucagag caggagcauc cucugcuggu    1080

uccugacugg caaaggacca gcguccucgu ucaaaacauu ccaagaaagg uuaaggaguu    1140

cccccaacca ucuucacugg cuuccaucag ugguaacugc uuuggucucu ucuuucaucu    1200

ggggaugaca auggaccucu cagcagaaac acacagucac auucgaauuc ggguggcauc    1260

cuccggagag agagagagga aggagauucc acacaggggu ggaguuucug acgaaggucc    1320

uaagggagug uuugugucug acucaggcgc cuggcacauu ucagggagaa acuccaaagu    1380

ccacacaaag auuuucuaag gaaugcacaa auugaaaaca cacucaaaag acaaacaugc    1440

aaguaaagaa aaaaaaaaga aagacuuuug uuuaaauuug uaaaaugcaa aacugaauga    1500

aacuguuacu accauaaauc aggauauguu ucaugaauau gagucuaccu caccuauauu    1560

gcacucuggc agaaguauuu cccacauuua auuauugccu ccccaaacuc uucccacccc    1620

ugcugccccu uccuccaucc cccauacuaa auccuagccu cguagaaguc uggucuaaug    1680

ugucagcagu agauauaaua uuuucauggu aaucuacuag cucugaucca uaagaaaaaa    1740

aagaucauua aaucaggaga uucccugucc uugauuuuug gagacacaau gguauagggu    1800

uguuuaugaa auauauugaa aaguaagugu uuguuacgcu uuaaagcagu aaaauuauuu    1860

uccuuuauau aaccggcuaa ugaaagaggu uggauugaau uuugauguac uuauuuuuuu    1920

auagauauuu auauucaaac aauuuauucc uuauauuuac cauguuaaau aucuguuugg    1980

gcaggccaua uuggucuaug uauuuuuaaa auauguauuu cuaaaugaaa uugagaacau    2040

gcuuuguuuu gccugucaag guaaugacuu uagaaaauaa auauuuuuuu ccuuacugua    2100

aaaaaaaaaa aa                                                        2112


<210> 18
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 18
ucgaaguauu ccgcguacgu gau                                            23


<210> 19
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 19
aucacguacg cggaauacuu cga                                            23


<210> 20
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 20
uaaguucuag cugugguggg uua                                            23


<210> 21
<211> 23
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial Sequence"
      /note="Synthetic"
      /mol_type="unassigned RNA"

<400> 21
uaacccacca cagcuagaac uca                                            23


<210> 22
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-9A-fluoro"
      /mol_type="unassigned RNA"

<400> 22
aaguaaauuc uccaaggcu                                                 19


<210> 23
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-9B-fluoro"
      /mol_type="unassigned RNA"

<400> 23
agccuuggag aauuuacuu                                                 19


<210> 24
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-10A-fluoro"
      /mol_type="unassigned RNA"

<400> 24
uauuauaucu acugcugac                                                 19


<210> 25
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-10B-fluoro"
      /mol_type="unassigned RNA"

<400> 25
gucagcagua gauauaaua                                                 19


<210> 26
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-11A-fluoro"
      /mol_type="unassigned RNA"

<400> 26
uuauccauca gggacgagc                                                 19


<210> 27
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-11B-fluoro"
      /mol_type="unassigned RNA"

<400> 27
gcucgucccu gauggauaa                                                 19


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-12A-fluoro"
      /mol_type="unassigned RNA"

<400> 28
cauuagacca gacuucuac                                                 19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-12B-fluoro"
      /mol_type="unassigned RNA"

<400> 29
guagaagucu ggucuaaug                                                 19


<210> 30
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-13A-fluoro"
      /mol_type="unassigned RNA"

<400> 30
acacucuuua uccaucagg                                                 19


<210> 31
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-13B-fluoro"
      /mol_type="unassigned RNA"

<400> 31
ccugauggau aaagagugu                                                 19


<210> 32
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-14A-fluoro"
      /mol_type="unassigned RNA"

<400> 32
ugcauguuug ucuuuugag                                                 19


<210> 33
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-14B-fluoro"
      /mol_type="unassigned RNA"

<400> 33
cucaaaagac aaacaugca                                                 19


<210> 34
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-15A-fluoro"
      /mol_type="unassigned RNA"

<400> 34
acuucuacga ggcuaggau                                                 19


<210> 35
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-15B-fluoro"
      /mol_type="unassigned RNA"

<400> 35
auccuagccu cguagaagu                                                 19


<210> 36
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-16A-fluoro"
      /mol_type="unassigned RNA"

<400> 36
acauagacca auauggccu                                                 19


<210> 37
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-16B-fluoro"
      /mol_type="unassigned RNA"

<400> 37
aggccauauu ggucuaugu                                                 19


<210> 38
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-17A-fluoro"
      /mol_type="unassigned RNA"

<400> 38
aaagucauua ccuugacag                                                 19


<210> 39
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-17B-fluoro"
      /mol_type="unassigned RNA"

<400> 39
cugucaaggu aaugacuuu                                                 19


<210> 40
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-18A-fluoro"
      /mol_type="unassigned RNA"

<400> 40
augugcucgg uuguggguc                                                 19


<210> 41
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-18B-fluoro"
      /mol_type="unassigned RNA"

<400> 41
gacccacaac cgagcacau                                                 19


<210> 42
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-19A-fluoro"
      /mol_type="unassigned RNA"

<400> 42
cuguuucuca uggucuccg                                                 19


<210> 43
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-19B-fluoro"
      /mol_type="unassigned RNA"

<400> 43
cggagaccau gagaaacag                                                 19


<210> 44
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-20A-fluoro"
      /mol_type="unassigned RNA"

<400> 44
ucugucacca augugcucg                                                 19


<210> 45
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..19
<223> /organism="Artificial Sequence"
      /note="EDN1-hc-20B-fluoro"
      /mol_type="unassigned RNA"

<400> 45
cgagcacauu ggugacaga                                                 19


