                         SEQUENCE LISTING

<110>  Isis Innovation Limited
 
<120>  Detection of Actue Myeloid Leukaemia (AML) Leukaemic Stem Cells 
       (LSC)

<130>  P43888WO

<150>  US 62/084756
<151>  2014-11-26

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  328
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Val Arg Arg Gly Ala Arg Ala Gly Pro Arg Met Pro Arg Gly 
1               5                   10                  15      


Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser Gly Phe Met Ser 
            20                  25                  30          


Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro Thr Gln Gly Thr 
        35                  40                  45              


Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu Thr Thr Thr Pro 
    50                  55                  60                  


Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser Gln His Gly Asn 
65                  70                  75                  80  


Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys Phe Thr Ser Thr 
                85                  90                  95      


Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser Ser Val Gln Ser 
            100                 105                 110         


Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro Ala Asn Val Ser 
        115                 120                 125             


Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro Gly Asn Val Ser 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser Pro Thr Lys Pro 
145                 150                 155                 160 


Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys Ala Glu Ile Lys 
                165                 170                 175     


Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly Ile Cys Leu Glu 
            180                 185                 190         


Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys Asp Arg Gly Glu 
        195                 200                 205             


Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala Asp Ala Asp Ala 
    210                 215                 220                 


Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser Glu Val Arg Pro 
225                 230                 235                 240 


Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu Ile Ser Ser Lys 
                245                 250                 255     


Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys Lys Leu Gly Ile 
            260                 265                 270         


Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln Ser Tyr Ser Gln 
        275                 280                 285             


Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu Leu Ala Val Leu 
    290                 295                 300                 


Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser Trp Ser Pro Thr 
305                 310                 315                 320 


Gly Glu Arg Leu Glu Leu Glu Pro 
                325             


<210>  2
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Cys Ser Arg Gly Trp Asp Ser Cys Leu Ala Leu Glu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Leu Ser Leu Leu Val Thr Ser Ile Gln Gly His Leu Val His 
            20                  25                  30          


Met Thr Val Val Ser Gly Ser Asn Val Thr Leu Asn Ile Ser Glu Ser 
        35                  40                  45              


Leu Pro Glu Asn Tyr Lys Gln Leu Thr Trp Phe Tyr Thr Phe Asp Gln 
    50                  55                  60                  


Lys Ile Val Glu Trp Asp Ser Arg Lys Ser Lys Tyr Phe Glu Ser Lys 
65                  70                  75                  80  


Phe Lys Gly Arg Val Arg Leu Asp Pro Gln Ser Gly Ala Leu Tyr Ile 
                85                  90                  95      


Ser Lys Val Gln Lys Glu Asp Asn Ser Thr Tyr Ile Met Arg Val Leu 
            100                 105                 110         


Lys Lys Thr Gly Asn Glu Gln Glu Trp Lys Ile Lys Leu Gln Val Leu 
        115                 120                 125             


Asp Pro Val Pro Lys Pro Val Ile Lys Ile Glu Lys Ile Glu Asp Met 
    130                 135                 140                 


Asp Asp Asn Cys Tyr Leu Lys Leu Ser Cys Val Ile Pro Gly Glu Ser 
145                 150                 155                 160 


Val Asn Tyr Thr Trp Tyr Gly Asp Lys Arg Pro Leu Pro Lys Glu Leu 
                165                 170                 175     


Gln Asn Ser Val Leu Glu Thr Thr Leu Met Pro His Asn Tyr Ser Arg 
            180                 185                 190         


Cys Tyr Thr Cys Gln Val Ser Asn Ser Val Ser Ser Lys Asn Gly Thr 
        195                 200                 205             


Val Cys Leu Ser Pro Pro Cys Thr Leu Ala Arg Ser Phe Gly Val Glu 
    210                 215                 220                 


Trp Ile Ala Ser Trp Leu Val Val Thr Val Pro Thr Ile Leu Gly Leu 
225                 230                 235                 240 


Leu Leu Thr 
            


<210>  3
<211>  972
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Glu Gln Ile 
            500                 505                 510         


His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly Phe Val Ile Val 
        515                 520                 525             


Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr Tyr Lys Tyr Leu 
    530                 535                 540                 


Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val Glu Glu Ile Asn 
545                 550                 555                 560 


Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu Pro Tyr Asp His 
                565                 570                 575     


Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly Lys Thr Leu Gly 
            580                 585                 590         


Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala Tyr Gly Leu Ile 
        595                 600                 605             


Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met Leu Lys Pro Ser 
    610                 615                 620                 


Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu Leu Lys Val Leu 
625                 630                 635                 640 


Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu Leu Gly Ala Cys 
                645                 650                 655     


Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr Cys Cys Tyr Gly 
            660                 665                 670         


Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser Phe Ile Cys Ser 
        675                 680                 685             


Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys Asn Leu Leu His 
    690                 695                 700                 


Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu Tyr Met Asp Met 
705                 710                 715                 720 


Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala Asp Lys Arg Arg 
                725                 730                 735     


Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val Thr Pro Ala Ile 
            740                 745                 750         


Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp Leu Leu Ser Phe 
        755                 760                 765             


Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala Ser Lys Asn Cys 
    770                 775                 780                 


Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu Thr His Gly Arg 
785                 790                 795                 800 


Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp Ile Lys Asn Asp 
                805                 810                 815     


Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro Val Lys Trp Met 
            820                 825                 830         


Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe Glu Ser Asp Val 
        835                 840                 845             


Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser Leu Gly Ser Ser 
    850                 855                 860                 


Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr Lys Met Ile Lys 
865                 870                 875                 880 


Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro Ala Glu Met Tyr 
                885                 890                 895     


Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu Lys Arg Pro Thr 
            900                 905                 910         


Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile Ser Glu Ser Thr 
        915                 920                 925             


Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro Asn Arg Gln Lys 
    930                 935                 940                 


Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val Gly Ser Thr Ala 
945                 950                 955                 960 


Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970         


<210>  4
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Pro Lys Gly Leu Leu Ser Leu Thr Phe Val Leu Phe Leu Ser 
1               5                   10                  15      


Leu Ala Phe Gly Ala Ser Tyr Gly Thr Gly Gly Arg Met Met Asn Cys 
            20                  25                  30          


Pro Lys Ile Leu Arg Gln Leu Gly Ser Lys Val Leu Leu Pro Leu Thr 
        35                  40                  45              


Tyr Glu Arg Ile Asn Lys Ser Met Asn Lys Ser Ile His Ile Val Val 
    50                  55                  60                  


Thr Met Ala Lys Ser Leu Glu Asn Ser Val Glu Asn Lys Ile Val Ser 
65                  70                  75                  80  


Leu Asp Pro Ser Glu Ala Gly Pro Pro Arg Tyr Leu Gly Asp Arg Tyr 
                85                  90                  95      


Lys Phe Tyr Leu Glu Asn Leu Thr Leu Gly Ile Arg Glu Ser Arg Lys 
            100                 105                 110         


Glu Asp Glu Gly Trp Tyr Leu Met Thr Leu Glu Lys Asn Val Ser Val 
        115                 120                 125             


Gln Arg Phe Cys Leu Gln Leu Arg Leu Tyr Glu Gln Val Ser Thr Pro 
    130                 135                 140                 


Glu Ile Lys Val Leu Asn Lys Thr Gln Glu Asn Gly Thr Cys Thr Leu 
145                 150                 155                 160 


Ile Leu Gly Cys Thr Val Glu Lys Gly Asp His Val Ala Tyr Ser Trp 
                165                 170                 175     


Ser Glu Lys Ala Gly Thr His Pro Leu Asn Pro Ala Asn Ser Ser His 
            180                 185                 190         


Leu Leu Ser Leu Thr Leu Gly Pro Gln His Ala Asp Asn Ile Tyr Ile 
        195                 200                 205             


Cys Thr Val Ser Asn Pro Ile Ser Asn Asn Ser Gln Thr Phe Ser Pro 
    210                 215                 220                 


Trp Pro Gly Cys Arg Thr Asp Pro Ser Glu Thr Lys Pro Trp Ala Val 
225                 230                 235                 240 


Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile Leu Ile Met Val Val 
                245                 250                 255     


Ile Leu Gln Leu Arg Arg Arg Gly Lys Thr Asn His Tyr Gln Thr Thr 
            260                 265                 270         


Val Glu Lys Lys Ser Leu Thr Ile Tyr Ala Gln Val Gln Lys Pro Gly 
        275                 280                 285             


Pro Leu Gln Lys Lys Leu Asp Ser Phe Pro Ala Gln Asp Pro Cys Thr 
    290                 295                 300                 


Thr Ile Tyr Val Ala Ala Thr Glu Pro Val Pro Glu Ser Val Gln Glu 
305                 310                 315                 320 


Thr Asn Ser Ile Thr Val Tyr Ala Ser Val Thr Leu Pro Glu Ser 
                325                 330                 335 


<210>  5
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gly Gln Val Val Thr Leu Ile Leu Leu Leu Leu Leu Lys Val 
1               5                   10                  15      


Tyr Gln Gly Lys Gly Cys Gln Gly Ser Ala Asp His Val Val Ser Ile 
            20                  25                  30          


Ser Gly Val Pro Leu Gln Leu Gln Pro Asn Ser Ile Gln Thr Lys Val 
        35                  40                  45              


Asp Ser Ile Ala Trp Lys Lys Leu Leu Pro Ser Gln Asn Gly Phe His 
    50                  55                  60                  


His Ile Leu Lys Trp Glu Asn Gly Ser Leu Pro Ser Asn Thr Ser Asn 
65                  70                  75                  80  


Asp Arg Phe Ser Phe Ile Val Lys Asn Leu Ser Leu Leu Ile Lys Ala 
                85                  90                  95      


Ala Gln Gln Gln Asp Ser Gly Leu Tyr Cys Leu Glu Val Thr Ser Ile 
            100                 105                 110         


Ser Gly Lys Val Gln Thr Ala Thr Phe Gln Val Phe Val Phe Asp Lys 
        115                 120                 125             


Val Glu Lys Pro Arg Leu Gln Gly Gln Gly Lys Ile Leu Asp Arg Gly 
    130                 135                 140                 


Arg Cys Gln Val Ala Leu Ser Cys Leu Val Ser Arg Asp Gly Asn Val 
145                 150                 155                 160 


Ser Tyr Ala Trp Tyr Arg Gly Ser Lys Leu Ile Gln Thr Ala Gly Asn 
                165                 170                 175     


Leu Thr Tyr Leu Asp Glu Glu Val Asp Ile Asn Gly Thr His Thr Tyr 
            180                 185                 190         


Thr Cys Asn Val Ser Asn Pro Val Ser Trp Glu Ser His Thr Leu Asn 
        195                 200                 205             


Leu Thr Gln Asp Cys Gln Asn Ala His Gln Glu Phe Arg Phe Trp Pro 
    210                 215                 220                 


Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr Leu 
225                 230                 235                 240 


Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu 
                245                 250                 255     


Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu 
            260                 265                 270         


Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly 
        275                 280                 285             


Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser 
    290                 295                 300                 


Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys 
305                 310                 315                 320 


Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr Ile 
                325                 330                 335     


Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg 
            340                 345                 350         


Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
        355                 360                 365 


<210>  6
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Phe Pro Cys Lys Phe Val Ala Ser Phe Leu Leu Ile Phe Asn 
1               5                   10                  15      


Val Ser Ser Lys Gly Ala Val Ser Lys Glu Ile Thr Asn Ala Leu Glu 
            20                  25                  30          


Thr Trp Gly Ala Leu Gly Gln Asp Ile Asn Leu Asp Ile Pro Ser Phe 
        35                  40                  45              


Gln Met Ser Asp Asp Ile Asp Asp Ile Lys Trp Glu Lys Thr Ser Asp 
    50                  55                  60                  


Lys Lys Lys Ile Ala Gln Phe Arg Lys Glu Lys Glu Thr Phe Lys Glu 
65                  70                  75                  80  


Lys Asp Thr Tyr Lys Leu Phe Lys Asn Gly Thr Leu Lys Ile Lys His 
                85                  90                  95      


Leu Lys Thr Asp Asp Gln Asp Ile Tyr Lys Val Ser Ile Tyr Asp Thr 
            100                 105                 110         


Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Leu Lys Ile Gln Glu 
        115                 120                 125             


Arg Val Ser Lys Pro Lys Ile Ser Trp Thr Cys Ile Asn Thr Thr Leu 
    130                 135                 140                 


Thr Cys Glu Val Met Asn Gly Thr Asp Pro Glu Leu Asn Leu Tyr Gln 
145                 150                 155                 160 


Asp Gly Lys His Leu Lys Leu Ser Gln Arg Val Ile Thr His Lys Trp 
                165                 170                 175     


Thr Thr Ser Leu Ser Ala Lys Phe Lys Cys Thr Ala Gly Asn Lys Val 
            180                 185                 190         


Ser Lys Glu Ser Ser Val Glu Pro Val Ser Cys Pro Glu Lys Gly Leu 
        195                 200                 205             


Asp Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
    210                 215                 220                 


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
225                 230                 235                 240 


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
                245                 250                 255     


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
            260                 265                 270         


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
        275                 280                 285             


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
    290                 295                 300                 


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
305                 310                 315                 320 


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
                325                 330                 335     


Pro Pro Met Gly Gln Gln Lys Thr His Cys Pro Leu Pro Leu Ile Lys 
            340                 345                 350         


Lys Asp Arg Asn Cys Leu Phe Gln 
        355                 360 


<210>  7
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  8
<211>  458
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asn Arg Gly Val Pro Phe Arg His Leu Leu Leu Val Leu Gln Leu 
1               5                   10                  15      


Ala Leu Leu Pro Ala Ala Thr Gln Gly Lys Lys Val Val Leu Gly Lys 
            20                  25                  30          


Lys Gly Asp Thr Val Glu Leu Thr Cys Thr Ala Ser Gln Lys Lys Ser 
        35                  40                  45              


Ile Gln Phe His Trp Lys Asn Ser Asn Gln Ile Lys Ile Leu Gly Asn 
    50                  55                  60                  


Gln Gly Ser Phe Leu Thr Lys Gly Pro Ser Lys Leu Asn Asp Arg Ala 
65                  70                  75                  80  


Asp Ser Arg Arg Ser Leu Trp Asp Gln Gly Asn Phe Pro Leu Ile Ile 
                85                  90                  95      


Lys Asn Leu Lys Ile Glu Asp Ser Asp Thr Tyr Ile Cys Glu Val Glu 
            100                 105                 110         


Asp Gln Lys Glu Glu Val Gln Leu Leu Val Phe Gly Leu Thr Ala Asn 
        115                 120                 125             


Ser Asp Thr His Leu Leu Gln Gly Gln Ser Leu Thr Leu Thr Leu Glu 
    130                 135                 140                 


Ser Pro Pro Gly Ser Ser Pro Ser Val Gln Cys Arg Ser Pro Arg Gly 
145                 150                 155                 160 


Lys Asn Ile Gln Gly Gly Lys Thr Leu Ser Val Ser Gln Leu Glu Leu 
                165                 170                 175     


Gln Asp Ser Gly Thr Trp Thr Cys Thr Val Leu Gln Asn Gln Lys Lys 
            180                 185                 190         


Val Glu Phe Lys Ile Asp Ile Val Val Leu Ala Phe Gln Lys Ala Ser 
        195                 200                 205             


Ser Ile Val Tyr Lys Lys Glu Gly Glu Gln Val Glu Phe Ser Phe Pro 
    210                 215                 220                 


Leu Ala Phe Thr Val Glu Lys Leu Thr Gly Ser Gly Glu Leu Trp Trp 
225                 230                 235                 240 


Gln Ala Glu Arg Ala Ser Ser Ser Lys Ser Trp Ile Thr Phe Asp Leu 
                245                 250                 255     


Lys Asn Lys Glu Val Ser Val Lys Arg Val Thr Gln Asp Pro Lys Leu 
            260                 265                 270         


Gln Met Gly Lys Lys Leu Pro Leu His Leu Thr Leu Pro Gln Ala Leu 
        275                 280                 285             


Pro Gln Tyr Ala Gly Ser Gly Asn Leu Thr Leu Ala Leu Glu Ala Lys 
    290                 295                 300                 


Thr Gly Lys Leu His Gln Glu Val Asn Leu Val Val Met Arg Ala Thr 
305                 310                 315                 320 


Gln Leu Gln Lys Asn Leu Thr Cys Glu Val Trp Gly Pro Thr Ser Pro 
                325                 330                 335     


Lys Leu Met Leu Ser Leu Lys Leu Glu Asn Lys Glu Ala Lys Val Ser 
            340                 345                 350         


Lys Arg Glu Lys Ala Val Trp Val Leu Asn Pro Glu Ala Gly Met Trp 
        355                 360                 365             


Gln Cys Leu Leu Ser Asp Ser Gly Gln Val Leu Leu Glu Ser Asn Ile 
    370                 375                 380                 


Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu Ile 
385                 390                 395                 400 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                405                 410                 415     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met 
            420                 425                 430         


Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro 
        435                 440                 445             


His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    450                 455             


<210>  9
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ser Gln Phe Arg Val Ser Pro Leu Asp Arg Thr 
            20                  25                  30          


Trp Asn Leu Gly Glu Thr Val Glu Leu Lys Cys Gln Val Leu Leu Ser 
        35                  40                  45              


Asn Pro Thr Ser Gly Cys Ser Trp Leu Phe Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Ala Ser Pro Thr Phe Leu Leu Tyr Leu Ser Gln Asn Lys Pro Lys Ala 
65                  70                  75                  80  


Ala Glu Gly Leu Asp Thr Gln Arg Phe Ser Gly Lys Arg Leu Gly Asp 
                85                  90                  95      


Thr Phe Val Leu Thr Leu Ser Asp Phe Arg Arg Glu Asn Glu Gly Cys 
            100                 105                 110         


Tyr Phe Cys Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
        115                 120                 125             


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
    130                 135                 140                 


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
145                 150                 155                 160 


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
                165                 170                 175     


Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
            180                 185                 190         


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
        195                 200                 205             


Arg Asn Arg Arg Arg Val Cys Lys Cys Pro Arg Pro Val Val Lys Ser 
    210                 215                 220                 


Gly Asp Lys Pro Ser Leu Ser Ala Arg Tyr Val 
225                 230                 235 


<210>  10
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Gly Lys Ser Glu Ser Gln Met Asp Ile Thr Asp Ile Asn Thr Pro 
1               5                   10                  15      


Lys Pro Lys Lys Lys Gln Arg Trp Thr Pro Leu Glu Ile Ser Leu Ser 
            20                  25                  30          


Val Leu Val Leu Leu Leu Thr Ile Ile Ala Val Thr Met Ile Ala Leu 
        35                  40                  45              


Tyr Ala Thr Tyr Asp Asp Gly Ile Cys Lys Ser Ser Asp Cys Ile Lys 
    50                  55                  60                  


Ser Ala Ala Arg Leu Ile Gln Asn Met Asp Ala Thr Thr Glu Pro Cys 
65                  70                  75                  80  


Thr Asp Phe Phe Lys Tyr Ala Cys Gly Gly Trp Leu Lys Arg Asn Val 
                85                  90                  95      


Ile Pro Glu Thr Ser Ser Arg Tyr Gly Asn Phe Asp Ile Leu Arg Asp 
            100                 105                 110         


Glu Leu Glu Val Val Leu Lys Asp Val Leu Gln Glu Pro Lys Thr Glu 
        115                 120                 125             


Asp Ile Val Ala Val Gln Lys Ala Lys Ala Leu Tyr Arg Ser Cys Ile 
    130                 135                 140                 


Asn Glu Ser Ala Ile Asp Ser Arg Gly Gly Glu Pro Leu Leu Lys Leu 
145                 150                 155                 160 


Leu Pro Asp Ile Tyr Gly Trp Pro Val Ala Thr Glu Asn Trp Glu Gln 
                165                 170                 175     


Lys Tyr Gly Ala Ser Trp Thr Ala Glu Lys Ala Ile Ala Gln Leu Asn 
            180                 185                 190         


Ser Lys Tyr Gly Lys Lys Val Leu Ile Asn Leu Phe Val Gly Thr Asp 
        195                 200                 205             


Asp Lys Asn Ser Val Asn His Val Ile His Ile Asp Gln Pro Arg Leu 
    210                 215                 220                 


Gly Leu Pro Ser Arg Asp Tyr Tyr Glu Cys Thr Gly Ile Tyr Lys Glu 
225                 230                 235                 240 


Ala Cys Thr Ala Tyr Val Asp Phe Met Ile Ser Val Ala Arg Leu Ile 
                245                 250                 255     


Arg Gln Glu Glu Arg Leu Pro Ile Asp Glu Asn Gln Leu Ala Leu Glu 
            260                 265                 270         


Met Asn Lys Val Met Glu Leu Glu Lys Glu Ile Ala Asn Ala Thr Ala 
        275                 280                 285             


Lys Pro Glu Asp Arg Asn Asp Pro Met Leu Leu Tyr Asn Lys Met Thr 
    290                 295                 300                 


Leu Ala Gln Ile Gln Asn Asn Phe Ser Leu Glu Ile Asn Gly Lys Pro 
305                 310                 315                 320 


Phe Ser Trp Leu Asn Phe Thr Asn Glu Ile Met Ser Thr Val Asn Ile 
                325                 330                 335     


Ser Ile Thr Asn Glu Glu Asp Val Val Val Tyr Ala Pro Glu Tyr Leu 
            340                 345                 350         


Thr Lys Leu Lys Pro Ile Leu Thr Lys Tyr Ser Ala Arg Asp Leu Gln 
        355                 360                 365             


Asn Leu Met Ser Trp Arg Phe Ile Met Asp Leu Val Ser Ser Leu Ser 
    370                 375                 380                 


Arg Thr Tyr Lys Glu Ser Arg Asn Ala Phe Arg Lys Ala Leu Tyr Gly 
385                 390                 395                 400 


Thr Thr Ser Glu Thr Ala Thr Trp Arg Arg Cys Ala Asn Tyr Val Asn 
                405                 410                 415     


Gly Asn Met Glu Asn Ala Val Gly Arg Leu Tyr Val Glu Ala Ala Phe 
            420                 425                 430         


Ala Gly Glu Ser Lys His Val Val Glu Asp Leu Ile Ala Gln Ile Arg 
        435                 440                 445             


Glu Val Phe Ile Gln Thr Leu Asp Asp Leu Thr Trp Met Asp Ala Glu 
    450                 455                 460                 


Thr Lys Lys Arg Ala Glu Glu Lys Ala Leu Ala Ile Lys Glu Arg Ile 
465                 470                 475                 480 


Gly Tyr Pro Asp Asp Ile Val Ser Asn Asp Asn Lys Leu Asn Asn Glu 
                485                 490                 495     


Tyr Leu Glu Leu Asn Tyr Lys Glu Asp Glu Tyr Phe Glu Asn Ile Ile 
            500                 505                 510         


Gln Asn Leu Lys Phe Ser Gln Ser Lys Gln Leu Lys Lys Leu Arg Glu 
        515                 520                 525             


Lys Val Asp Lys Asp Glu Trp Ile Ser Gly Ala Ala Val Val Asn Ala 
    530                 535                 540                 


Phe Tyr Ser Ser Gly Arg Asn Gln Ile Val Phe Pro Ala Gly Ile Leu 
545                 550                 555                 560 


Gln Pro Pro Phe Phe Ser Ala Gln Gln Ser Asn Ser Leu Asn Tyr Gly 
                565                 570                 575     


Gly Ile Gly Met Val Ile Gly His Glu Ile Thr His Gly Phe Asp Asp 
            580                 585                 590         


Asn Gly Arg Asn Phe Asn Lys Asp Gly Asp Leu Val Asp Trp Trp Thr 
        595                 600                 605             


Gln Gln Ser Ala Ser Asn Phe Lys Glu Gln Ser Gln Cys Met Val Tyr 
    610                 615                 620                 


Gln Tyr Gly Asn Phe Ser Trp Asp Leu Ala Gly Gly Gln His Leu Asn 
625                 630                 635                 640 


Gly Ile Asn Thr Leu Gly Glu Asn Ile Ala Asp Asn Gly Gly Leu Gly 
                645                 650                 655     


Gln Ala Tyr Arg Ala Tyr Gln Asn Tyr Ile Lys Lys Asn Gly Glu Glu 
            660                 665                 670         


Lys Leu Leu Pro Gly Leu Asp Leu Asn His Lys Gln Leu Phe Phe Leu 
        675                 680                 685             


Asn Phe Ala Gln Val Trp Cys Gly Thr Tyr Arg Pro Glu Tyr Ala Val 
    690                 695                 700                 


Asn Ser Ile Lys Thr Asp Val His Ser Pro Gly Asn Phe Arg Ile Ile 
705                 710                 715                 720 


Gly Thr Leu Gln Asn Ser Ala Glu Phe Ser Glu Ala Phe His Cys Arg 
                725                 730                 735     


Lys Asn Ser Tyr Met Asn Pro Glu Lys Lys Cys Arg Val Trp 
            740                 745                 750 


<210>  11
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ser 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Val Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  12
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  13
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Tyr Gly Lys Ile Ile Phe Val Leu Leu Leu Ser Ala Ile Val Ser 
1               5                   10                  15      


Ile Ser Ala Ser Ser Thr Thr Gly Val Ala Met His Thr Ser Thr Ser 
            20                  25                  30          


Ser Ser Val Thr Lys Ser Tyr Ile Ser Ser Gln Thr Asn Asp Thr His 
        35                  40                  45              


Lys Arg Asp Thr Tyr Ala Ala Thr Pro Arg Ala His Glu Val Ser Glu 
    50                  55                  60                  


Ile Ser Val Arg Thr Val Tyr Pro Pro Glu Glu Glu Thr Gly Glu Arg 
65                  70                  75                  80  


Val Gln Leu Ala His His Phe Ser Glu Pro Glu Ile Thr Leu Ile Ile 
                85                  90                  95      


Phe Gly Val Met Ala Gly Val Ile Gly Thr Ile Leu Leu Ile Ser Tyr 
            100                 105                 110         


Gly Ile Arg Arg Leu Ile Lys Lys Ser Pro Ser Asp Val Lys Pro Leu 
        115                 120                 125             


Pro Ser Pro Asp Thr Asp Val Pro Leu Ser Ser Val Glu Ile Glu Asn 
    130                 135                 140                 


Pro Glu Thr Ser Asp Gln 
145                 150 


<210>  14
<211>  7948
<212>  DNA
<213>  Homo sapiens

<400>  14
agatgcacag tggagctcgc tacccctcct ctcctccaaa aatctcatca gacgatatcc       60

cagacaggag cggttagaga gagaggaatc acatctccac acagttttag ggtgcttttt      120

atttttacaa atcttcttgt gtgttttttg ccttgatcca tcctcttccc gccgagatcg      180

tatggcgcct ttctctcgat tatgaatttg atcaatccat ctttggaaga aaacccacat      240

agttttttca ggagctgaaa attgagtcgt tatagaaata ttaggacata ttttcaatca      300

tttcggtgcc cgaagggagg caagagctca gttttatatt gagacattac gccggctgaa      360

ggcagagaat gcgtttccct gccaggacct gatgcaatcc attcaagcca acaagtttgg      420

agagaatgtt gagttcaatc aattcagaac gtcgagatgg agcccaactc actccagtgg      480

gtcggctcac cgtgtggctt gcacggacct tacattttct acaaggcttt tcaattccac      540

cttgaaggca aaccaagaat tttgtccctt ggcgactttt tctttgtaag atgtacgcca      600

aaggatccga tttgcatagc ggagctccag ctgttgtggg aagagaggac cagccggcaa      660

cttttatcca gctctaaact ttatttcctc ccagaagaca ctccccaggg cagaaatagc      720

gaccatggcg aggatgaagt cattgctgtt tccgaaaagg tgattgtgaa gcttgaagac      780

ctggtcaagt gggtacattc tgatttctcc aagtggagat gtggcttcca cgctggacca      840

gtgaaaactg aggccttggg aaggaatgga cagaaggaag ctctgctgaa gtacaggcag      900

tcaaccctaa acagtggact caacttcaaa gacgttctca aggagaaggc agacctgggg      960

gaggacgagg aagaaacgaa cgtgatagtt ctcagctacc cccagtactg ccggtaccgc     1020

tcgatgctga aacgcatcca ggataagcca tcttccattc taacggacca gtttgcattg     1080

gccctggggg gcattgcagt ggtcagcagg aaccctcaga tcctgtactg tcgggacacc     1140

tttgaccacc cgactctcat agaaaacgag agtatatgcg atgagtttgc gccaaatctt     1200

aaaggcagac cacgcaaaaa gaaaccatgc ccacaaagaa gagattcatt cagtggtgtt     1260

aaggattcca acaacaattc cgatggcaaa gccgttgcca aggtgaaatg tgaggccagg     1320

tcagccttga ccaagccgaa gaataaccat aactgtaaaa aagtctcaaa tgaagaaaaa     1380

ccaaaggttg ccattggtga agagtgcagg gcagatgaac aagccttctt ggtggcactt     1440

tataaataca tgaaagaaag gaaaacgccg atagaacgaa taccctattt aggttttaaa     1500

cagattaacc tttggactat gtttcaagct gctcaaaaac tgggaggata tgaaacaata     1560

acagcccgcc gtcagtggaa acatatttat gatgaattag gcggtaatcc tgggagcacc     1620

agcgctgcca cttgtacccg cagacattat gaaagattaa tcctaccata tgaaagattt     1680

attaaaggag aagaagataa gcccctgcct ccaatcaaac ctcggaaaca ggagaacagt     1740

tcacaggaaa atgagaacaa aacaaaagta tctggaacca aacgcatcaa acatgaaata     1800

cctaaaagca agaaagaaaa agaaaatgcc ccaaagcccc aggatgcagc agaggtttca     1860

tcagagcaag aaaaagaaca agagacttta ataagccaga aaagcatccc tgagcctctc     1920

ccagcagcag acatgaagaa aaaaatagaa gggtatcagg aattttcagc gaagcccctg     1980

gcatccagag tagacccaga gaaggacaac gaaacagacc aaggttccaa cagtgagaag     2040

gtggcagagg aggcgggaga gaaggggccc acacctccac tcccaagtgc tcctctggcc     2100

ccagaaaaag attcagcctt ggtccctggg gccagcaaac agccactcac ctctcctagt     2160

gccctggtgg actcaaaaca agaatccaaa ctgtgctgtt ttacagagag ccctgaaagt     2220

gaaccccaag aagcatcctt ccccagcttc cccaccacac agccaccgct ggcaaaccag     2280

aatgagacgg aggatgacaa actgcccgcc atggcagatt acattgccaa ctgcaccgtg     2340

aaggtggacc agctgggcag tgacgacatc cacaatgcgc tcaagcagac cccaaaggtc     2400

cttgtggtcc agtcgtttga catgttcaaa gacaaagacc tgactgggcc catgaacgag     2460

aaccatggac ttaattacac gcccctgctc tactctaggg gcaacccagg catcatgtcc     2520

ccactggcca agaaaaagct tttgtcccaa gtgagtgggg ccagcctctc cagcagctac     2580

ccttatggct ccccaccccc tttgatcagc aaaaagaaac tgattgctag ggatgacttg     2640

tgttccagtt tgtcccagac ccaccatggc caaagcactg accatatggc ggtcagccgg     2700

ccatcagtga ttcagcacgt ccagagtttc agaagcaagc cctcggaaga gagaaagacc     2760

atcaatgaca tctttaagca tgagaaactg agtcgatcag atccccaccg ctgcagcttc     2820

tccaagcatc accttaaccc ccttgctgac tcctacgtcc tgaagcaaga aattcaggag     2880

ggcaaggata aactcttaga gaaaagggcc ctcccccatt cccacatgcc tagcttcctg     2940

gctgacttct actcgtcccc tcatctccat agcctctaca gacacaccga gcaccatctt     3000

cataatgaac agacatccaa atacccttcc agggacatgt acagggaatc ggaaaacagt     3060

tcttttcctt cccacagaca ccaagaaaag ctccatgtaa attatctcac gtccctgcac     3120

ctgcaagaca aaaagtcggc ggcagcagaa gcccctacgg atgatcagcc tacagatctg     3180

agccttccca agaacccgca caaacctacc ggcaaggtcc tgggcctggc tcattccacc     3240

acagggcccc aggagagcaa aggcatctcc cagttccagg tcttaggcag ccagagtcga     3300

gactgtcacc ccaaagcctg tcgggtatca cccatgacca tgtcaggccc taaaaaatac     3360

cctgaatcgc tttcaagatc aggaaaacct caccatgtga gactggagaa tttcaggaag     3420

atggaaggca tggtccaccc aatcctgcac cggaaaatga gcccgcagaa cattggggcg     3480

gcgcggccga tcaagcgcag cctggaggat ttggaccttg tgattgcagg gaaaaaggcc     3540

cgggcagtgt ctcccttaga cccatccaag gaggtctctg ggaaggagaa ggcctctgag     3600

caggagagtg aaggcagcaa agcagcgcac ggtgggcatt ccgggggcgg atcagaaggc     3660

cacaagcttc ccctctcctc ccctatcttc ccaggtctgt attccgggag cctgtgtaac     3720

tcgggcctca actccaggct cccggctggg tattctcatt ctctgcagta cttgaaaaac     3780

cagactgtgc tttctccact catgcagccc ctggctttcc actcgcttgt gatgcaaaga     3840

ggaattttta catcaccgac aaattctcag cagctgtaca gacacttggc tgcggctaca     3900

cctgtaggaa gttcatatgg ggaccttttg cataacagca tttacccttt agctgctata     3960

aatcctcaag ctgcctttcc atcttcccag ctgtcatccg tgcaccccag tacaaaactg     4020

taggctcagc tctgcccagc agtccaaagc ggcatggcca acagagcttc actccttacc     4080

caggagtgct ggcttataga gttagaagtc agtatttctt ctaatctgag gctatgatca     4140

gtcccagctg taggggccca gaggggaggt gaacatgcct gatttttgtg ggacaactct     4200

agcccacaaa ctgactggct ggtgagtctt gactcccttc caacacagat gcccaggcac     4260

ctccagatca ttcacttcgc acgtgggcct tgtgaaggga tttgtgaata tccaggaaga     4320

acttagagga ccccatctga gttcggatgg tcaggaaaca atctgggcaa aaaagaggca     4380

ggcatttcaa aggaaggggc aaggaagact ggcaaacaga tggcaaggga tgcccctctt     4440

tttcataaaa ctctccaagg ttcaatcaat gcaatgtata gtgaaacttc aatagatctt     4500

tcattttgac actattaaac aatccagaga agtaaacact gttaaattga ctgtatatat     4560

ttgcttctta aaactacctg tatcactgtt tgctcaccta atttatatac aggtagttcc     4620

attttctccc agttccttct cgtctttttt tttttttttt tttttttttt tattaaatgg     4680

tattgctttt gtttgcaggt ctttttgttt ttgttttgtt tttgaggctg actgactgtc     4740

ctagttgttg tgtgtttgta atttttccac atcttatttt gagcagcttt gggtggtaaa     4800

gttattgttt acaaattgaa gcaactgatt ctagtggaac aaatgaaaaa gaaacagtca     4860

agcacacaat agtgcaaaga acgttccttt gtagatccgc aacttaagga ttttgttcct     4920

cataaatggc atagttgaaa gagcttatac actgcttacc cagccaaatg ctttgctttg     4980

aagtattggg ttctgtgaaa atattgagca ttgtacttac cttatctagg ctgtgaaact     5040

gtcctacata ccagagaatc ataaaaacaa aaacctcact ggcagcaagc tgccgaataa     5100

caacagagtc tagaggacat atttgtgggc tgcacagata ttttaggaat ttcagaaatt     5160

agaacaggag ccaaaatgat ttacattggc gttggcactg attcctttaa atggtctggg     5220

aaagggggtt gggaagagga tggagctcaa ctggccagaa gaggagcagc tgcagtcctg     5280

atagcttctc tagcctcggt cttttgagtg ataagtagtc atgttgtttt catccagttg     5340

gtttcttgtc attcccaaga agaatctccc aggccacatc tttggggata actgacatac     5400

tggattagcc ttttcaaaag aaaagtcatc ctatttggtt ttatggggtg tgagttttgt     5460

gtgtacacac acagaaacat gtaaggtggt ttgggtcatg tttttaacca cctggcaata     5520

cagtccactt tctggtttct tttattgtgg gaagtaaatg gtcaagctgc tcaggcagtg     5580

aaaagatgtg gagaatgtcc gttgtcattc ttgccactgt attccatttg ctaccgagat     5640

ataacattaa ggtggacaca ttttctaact gtattaatta aaagtcaatg gatacagaga     5700

gtggattttc tccccaagtc ccatccctgc tgaagaccgc ttggatgaac tccccaaccc     5760

actgtgcccc tcccgcaaca ctaccagtag actttagaac catagttaac taagtctttt     5820

acctctgaga tacttaattc tgggaaaatt ggtgacaatt ttcaacttct aaataggtaa     5880

ctcgactgca aaataatcaa aactgataac aatgaaactg cggctcttaa acaaagccat     5940

gcatgccgtg catttgtatt gaaatgtctc catgatatga agccaaatat tcaatgtaac     6000

atacttaata tccaaaggtg gaaacaaaag aatgtagaga tccagtgtta agagttccat     6060

ttgcttcaat taattattta ccttcctgtg gaataatata tatatatata tttaatagaa     6120

ccatagatag actagtagaa tttagattat aaatgtgtga gtgcagatta tcctgctatt     6180

gcacaagcta gaggggggaa aaatctcaat tccagctggc aagatgctag ccaggacaca     6240

tataagaaag ttgcactaga ttgaatggtc acagaatcgg aggacatgga agaaaaagga     6300

aacttcggtg gttctgcagc agacatgggc taggtcatat gtggtttcta tgagttcgtg     6360

tctcaaaaaa aaaaggaggg ggggcatctg tccccggtgg agctcaccta tttggaatat     6420

ggggcatttg ttttttccac tgcaatgatt tcagtctggt ttcatcatgt tggaattcga     6480

tcacaccatt ttcaaacaat gttaacatag tccagctttt gtttttctca tctcttctga     6540

gaggagactc actgtttctg tctgaggaag ctcataccct cggcaaaaca tcaggacaaa     6600

taaagagaaa tgggggtacg cattcccaac agaagcagtg tgttatttgt tttaaaactc     6660

tgaacagaga tcttggaaat ctttcaaaaa gaccattgaa ttcttcattg gctgagaacg     6720

acgttttaaa atgtcttaaa taaggctttg tttgcattgt ttgagttcaa ggggccttat     6780

tattgaatgg aattgcacaa gcctttcttt gtgcaatcaa accattgtta ttggtagttc     6840

tgtaaaggaa actgtggaat cgaattggca gtggagtcat aaatctattt actgagtgtg     6900

gcttccaaga aatgttgcaa ttcaaaatgc actaagtctg tgatttattg gagatttgga     6960

gattctaaat aatattttta aaaaacttcc atgcaacttc tggtttaatg tttggcaact     7020

ccacatgata aaaaaataaa aacagcccaa ccgagtttcg gaattaagta ttcttctagt     7080

aagtgattca aacttgtaat atttgccaca ggactgactt atttatttac tagctagaag     7140

ctcttaagtt cacttgttta tcagggcata tacagaaggg tttgttaaaa ctcgatgtta     7200

actttacaac tttctgacct ggtgcatgaa ttctcaagta ctgtatttca ctgtgttggt     7260

gtgtctgatg gaaatttcga ggtggtccca caaaaatatt ttatgtagtg tgccttcaaa     7320

gagaaccatt tatttctctt cacttatcgt cccacaaagt cacatttggt ggtggtcagc     7380

caagtcgcat ctggtctagt tttactcttg tcccaatttt aaagagaaat gggaatgagt     7440

ttgccctggt gagacccata ccattgcaat gattatcttg agcacttaaa gtccagtgtt     7500

ggctgttagt gtatttgata ttctgcctgt ctcctcatgg ttgaaatatg tctgaagaat     7560

agcagcataa tctcttggct gtttatactt ttttaaactt tcctgtgttg taaatattgt     7620

atacttttgg tgattccagc tatgtaacct ctatgctctg taaggtgatt atttgtatat     7680

agcaacatgg cccagtgata ttatatagtt tcccaatgga gaggttattg agtaaccttt     7740

gcattagttt aaacactacc agaagaatgc tgagccaact ataaacactc aattttgtat     7800

gttttccaaa ttgtacttat tactgctttt gatactgtat tacgtgccaa tagtttccca     7860

atcacatagc aggcaagaga tattttgtac tttttgatcc actgtaatat ttaataaaaa     7920

atgttactat ctgtttcctt taaaaaaa                                        7948


<210>  15
<211>  2088
<212>  DNA
<213>  Homo sapiens

<400>  15
tccgctccgt tcggccggtt ctcccgggaa gctattaata gcattacgtc agcctgggac       60

tggcaacacg gagtaaacga ccgcgccgcc agcctgaggg ctataaaagg ggtgatgcaa      120

cgctctccaa gccacagtcg cacgcagcca ggcgcgcact gcacagctct cttctctcgc      180

cgccgcccga gcgcaccctt cagcccgcgc gccggccgtg agtcctcggt gctcgcccgc      240

cggccagaca aacagcccgc ccgaccccgt cccgaccctg gccgccccga gcggagcctg      300

gagcaaaatg atgcttcaac acccaggcca ggtctctgcc tcggaagtga gtgcttctgc      360

catcgtcccc tgcctgtccc ctcctgggtc actggtgttt gaggattttg ctaacctgac      420

gccctttgtc aaggaagagc tgaggtttgc catccagaac aagcacctct gccaccggat      480

gtcctctgcg ctggaatcag tcactgtcag cgacagaccc ctcggggtgt ccatcacaaa      540

agccgaggta gcccctgaag aagatgaaag gaaaaagagg cgacgagaaa gaaataagat      600

tgcagctgca aagtgccgaa acaagaagaa ggagaagacg gagtgcctgc agaaagagtc      660

ggagaagctg gaaagtgtga atgctgaact gaaggctcag attgaggagc tcaagaacga      720

gaagcagcat ttgatataca tgctcaacct tcatcggccc acgtgtattg tccgggctca      780

gaatgggagg actccagaag atgagagaaa cctctttatc caacagataa aagaaggaac      840

attgcagagc taagcagtcg tggtatgggg gcgactgggg agtcctcatt gaatcctcat      900

tttataccca aaaccctgaa gccattggag agctgtcttc ctgtgtacct ctagaatccc      960

agcagcagag aaccatcaag gcgggagggc ctgcagtgat tcagcaggcc cttcccattc     1020

tgccccagag tgggtcttgg accagggcaa gtgcatcttt gcctcaactc caggatttag     1080

gccttaacac actggccatt cttatgttcc agatggcccc cagctggtgt cctgcccgcc     1140

tttcatctgg attctacaaa aaaccaggat gcccaccgtt aggattcagg cagcagtgtc     1200

tgtacctcgg gtgggaggga tggggccatc tccttcaccg tggctaccat tgtcactcgt     1260

aggggatgtg gagtgagaac agcatttagt gaagttgtgc aacggccagg gttgtgcttt     1320

ctagcaaata tgctgttatg tccagaaatt gtgtgtgcaa gaaaactagg caatgtactc     1380

ttccgatgtt tgtgtcacac aacactgatg tgacttttat atgctttttc tcagatctgg     1440

tttctaagag ttttgggggg cggggctgtc accacgtgca gtatctcaag atattcaggt     1500

ggccagaaga gcttgtcagc aagaggagga cagaattctc ccagcgttaa cacaaaatcc     1560

atgggcagta tgatggcagg tcctctgttg caaactcagt tccaaagtca caggaagaaa     1620

gcagaaagtt caacttccaa agggttagga ctctccactc aatgtcttag gtcaggagtt     1680

gtgtctaggc tggaagagcc aaagaatatt ccattttcct ttccttgtgg ttgaaaacca     1740

cagtcagtgg agagatgttt ggaaaccaca gtcagtggag cctgggtggt acccaggctt     1800

tagcattatt ggatgtcaat agcattgttt ttgtcatgta gctgttttaa gaaatctggc     1860

ccagggtgtt tgcagctgtg agaagtcact cacactggcc acaaggacgc tggctactgt     1920

ctattaaaat tctgatgttt ctgtgaaatt ctcagagtgt ttaattgtac tcaatggtat     1980

cattacaatt ttctgtaaga gaaaatatta cttatttatc ctagtattcc taacctgtca     2040

gaataataaa tattggaacc aagacatggt aaacaaaaaa aaaaaaaa                  2088


<210>  16
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  16
acagacctgc cccgccatga cccggctgac agtcctggcc ctgctggctg gtctgctggc       60

gtcctcgagg gccggctcca gccccctttt ggacatcgtt ggcggccgga aggcgaggcc      120

ccgccagttc ccgttcctgg cctccattca gaatcaaggc aggcacttct gcgggggtgc      180

cctgatccat gcccgcttcg tgatgaccgc ggccagctgc ttccaaagcc agaaccccgg      240

ggttagcacc gtggtgctgg gtgcctatga cctgaggcgg cgggagaggc agtcccgcca      300

gacgttttcc atcagcagca tgagcgagaa tggctacgac ccccagcaga acctgaacga      360

cctgatgctg cttcagctgg accgtgaggc caacctcacc agcagcgtga cgatactgcc      420

actgcctctg cagaacgcca cggtggaagc cggcaccaga tgccaggtgg ccggctgggg      480

gagccagcgc agtggggggc gtctctcccg ttttcccagg tttgtcaacg tgactgtgac      540

ccccgaggac cagtgtcgcc ccaacaacgt gtgcaccggt gtgctcaccc gccgcggtgg      600

catctgcaat ggggacgggg gcacccccct cgtctgcgag ggcctggccc acggcgtggc      660

ctccttttcc ctggggccct gtggccgagg ccctgacttc ttcacccgag tggcgctctt      720

ccgagactgg atcgatggtg ttctcaacaa cccgggaccg gggccagcct aggggggcct      780

gtgacctccc atggagccca gccccgccct ccacacctcc ggcgctccgc acccacctcc      840

cacggccccg cccctgcccc cgctccggcc agaggggccc tggctgtaat aaagaagccg      900

atctctcctc tg                                                          912


<210>  17
<211>  3435
<212>  DNA
<213>  Homo sapiens

<400>  17
acagcaacta tgaaataatc gtagtatgag aggcagagat cggggcgaga caatggggat       60

gtgggcgcgg gagccccgtt ccggcttagc agcacctccc agccccgcag aataaaaccg      120

atcgcgcccc ctccgcgcgc gccctccccc gagtgcggag cgggaggagg cggcggcggc      180

cgaggaggag gaggaggagg ccccggagga ggaggcgttg gaggtcgagg cggaggcgga      240

ggaggaggag gccgaggcgc cggaggaggc cgaggcgccg gagcaggagg aggccggccg      300

gaggcggcat gagacgagcg tggcggccgc ggctgctcgg ggccgcgctg gttgcccatt      360

gacagcggcg tctgcagctc gcttcaagat ggccgcttgg ctcgcattca ttttctgctg      420

aacgactttt aactttcatt gtcttttccg cccgcttcga tcgcctcgcg ccggctgctc      480

tttccgggat tttttatcaa gcagaaatgc atcgaacaac gagaatcaag atcactgagc      540

taaatcccca cctgatgtgt gtgctttgtg gagggtactt cattgatgcc acaaccataa      600

tagaatgtct acattccttc tgtaaaacgt gtattgttcg ttacctggag accagcaagt      660

attgtcctat ttgtgatgtc caagttcaca agaccagacc actactgaat ataaggtcag      720

ataaaactct ccaagatatt gtatacaaat tagttccagg gcttttcaaa aatgaaatga      780

agagaagaag ggatttttat gcagctcatc cttctgctga tgctgccaat ggctctaatg      840

aagatagagg agaggttgca gatgaagata agagaattat aactgatgat gagataataa      900

gcttatccat tgaattcttt gaccagaaca gattggatcg gaaagtaaac aaagacaaag      960

agaaatctaa ggaggaggtg aatgataaaa gatacttacg atgcccagca gcaatgactg     1020

tgatgcactt aagaaagttt ctcagaagta aaatggacat acctaatact ttccagattg     1080

atgtcatgta tgaggaggaa cctttaaagg attattatac actaatggat attgcctaca     1140

tttatacctg gagaaggaat ggtccacttc cattgaaata cagagttcga cctacttgta     1200

aaagaatgaa gatcagtcac cagagagatg gactgacaaa tgctggagaa ctggaaagtg     1260

actctgggag tgacaaggcc aacagcccag caggaggtat tccctccacc tcttcttgtt     1320

tgcctagccc cagtactcca gtgcagtctc ctcatccaca gtttcctcac atttccagta     1380

ctatgaatgg aaccagcaac agccccagcg gtaaccacca atcttctttt gccaatagac     1440

ctcgaaaatc atcagtaaat gggtcatcag caacttcttc tggttgatac ctgagactgt     1500

taaggaaaaa aattttaaac ccctgattta tatagatatc ttcatgccat tacagctttc     1560

tagatgctaa tacatgtgac tatcgtccaa tttgctttct tttgtagtga cattaaattt     1620

ggctataaaa gatggactac atgtgatact cctatggacg ttaattgaaa agaaagattg     1680

ttgttataaa gaattggttt cttggaaagc aggcaagact ttttctctgt gttaggaaag     1740

atgggaaatg gtttctgtaa ccattgtttg gatttggaag tactctgcag tggacataag     1800

cattgggcca tagtttgtta atctcaacta acgcctacat tacattctcc ttgatcgttc     1860

ttgttattac gctgttttgt gaacctgtag aaaacaagtg ctttttatct tgaaattcaa     1920

ccaacggaaa gaatatgcat agaataatgc attctatgta gccatgtcac tgtgaataac     1980

gatttcttgc atatttagcc attttgattc ctgtttgatt tatacttctc tgttgctacg     2040

caaaaccgat caaagaaaag tgaacttcag ttttacaatc tgtatgccta aaagcgggta     2100

ctaccgttta ttttactgac ttgtttaaat gattcgcttt tgtaagaatc agatggcatt     2160

atgcttgttg tacaatgcca tattggtata tgacataaca ggaaacagta ttgtatgata     2220

tatttataaa tgctataaag aaatattgtg tttcatgcat tcagaaatga ttgttaaaat     2280

tctcccaact ggttcgacct ttgcagatac ccataaccta tgttgagcct tgcttaccag     2340

caaagaatat ttttaatgtg gatatctaat tctaaagtct gttccattag aagcaattgg     2400

cacatctttc tatactttat atacttttct ccagtaatac atgtttactt taaagattgt     2460

tgcagtgaag aaaaaccttt aactgagaaa tatggaaacc gtcttaattt tccattggct     2520

atgatggaat taatattgta ttttaaaaat gcatattgat cactataatt ctaaaacaat     2580

tttttaaata aaccagcagg ttgctaaaag aaggcatttt atctaaagtt attttaatag     2640

gtggtatagc agtaatttta aatttaagag ttgcttttac agttaacaat ggaatatgcc     2700

ttctctgcta tgtctgaaaa tagaagctat ttattatgag cttctacagg tatttttaaa     2760

tagagcaagc atgttgaatt taaaatatga ataaccccac ccaacaattt tcagtttatt     2820

ttttgctttg gtcgaacttg gtgtgtgttc atcacccatc agttatttgt gagggtgttt     2880

attctatatg aatattgttt catgtttgta tgggaaaatt gtagctaaac atttcattgt     2940

ccccagtctg caaaagaagc acaattctat tgctttgtct tgcttatagt cattaaatca     3000

ttacttttac atatattgct gttacttctg ctttctttaa aaatatagta aaggatgttt     3060

tatgaagtca caagatacat atatttttat tttgacctaa atttgtacag tcccattgta     3120

agtgttgttt ctaattatag atgtaaaatg aaatttcatt tgtaattgga aaaaatccaa     3180

taaaaaggat attcatttag aaaatagcta agatctttaa taaaaatttg atatgaaaag     3240

cacaatgtgc agaagttatg gaaaacctat agaggattac aacaggtaaa cgttaaagag     3300

aatacattgc tgacttatag tgatgtggct aagaagtaca tgctttgttg taaaattgct     3360

tgaaagccca ttgaaagatg tatctgttta tttacagtct ttgaagtaaa agttaccaat     3420

gtttgccaat aaaaa                                                      3435


<210>  18
<211>  1423
<212>  DNA
<213>  Homo sapiens

<400>  18
gaccaacgga ccggacagag acgaggagag gaacaggaag agagaagctg ggagaatcgg       60

gaacctgggg gctagtgacc tgcacacagg gcaggggcac tcggcagttc ccagaggcca      120

cccctcccac cccagacatc cagacatctg gaactttggg tgccaagagt ccagcttaat      180

gcaggcagcc tggcttttgg gggctttggt ggtcccccag ctcttgggct ttggccatgg      240

ggctcgggga gcagagaggg agtgggaggg aggctgggga ggtgcccagg aggaggagcg      300

ggagagggag gccctgatgc tgaagcatct gcaggaagcc ctaggactgc ctgctgggag      360

gggggatgag aatcctgccg gaactgttga gggaaaagag gactgggaga tggaggagga      420

ccagggggag gaagaggagg aggaagcaac gccaacccca tcctccggcc ccagcccctc      480

tcccacccct gaggacatcg tcacttacat cctgggccgc ctggccggcc tggacgcagg      540

cctgcaccag ctgcacgtcc gtctgcacgc gttggacacc cgcgtggtcg agctgaccca      600

ggggctgcgg cagctgcgga acgcggcagg cgacacccgc gatgccgtgc aagccctgca      660

ggaggcgcag ggtcgcgccg agcgcgagca cggccgcttg gagggctgcc tgaaggggct      720

gcgcctgggc cacaagtgct tcctgctctc gcgcgacttc gaagctcagg cggcggcgca      780

ggcgcggtgc acggcgcggg gcgggagcct ggcgcagccg gcagaccgcc agcagatgga      840

ggcgctcact cggtacctgc gcgcggcgct cgctccctac aactggcccg tgtggctggg      900

cgtgcacgat cggcgcgccg agggcctcta cctcttcgaa aacggccagc gcgtgtcctt      960

cttcgcctgg catcgctcac cccgccccga gctcggcgcc cagcccagcg cctcgccgca     1020

tccgctcagc ccggaccagc ccaacggtgg cacgctcgag aactgcgtgg cgcaggcctc     1080

tgacgacggc tcctggtggg accacgactg ccagcggcgt ctctactacg tctgcgagtt     1140

ccccttctag cggggccggt accccgcctc cctgcccatc ccaccacccg gcctttccct     1200

gcgccgtgcc caccctcctc cggaatctcc cttcccttcc tggccacgaa tggcagcgtc     1260

ctccccgacc cccagtctgg gcgcttctgg gagggctctt gcggtgccgg cactcctcct     1320

tgttagtgtc tttccttgaa ggggcgggca ccaggctagg tccggtgcca ataaatcctt     1380

gtggaatctg acttgagggg cagtgaaaaa aaaaaaaaaa aaa                       1423


<210>  19
<211>  838
<212>  DNA
<213>  Homo sapiens

<400>  19
tgctgtttgt ggaaaataaa gcattctata ggcggagcta gtgaacgcct cttttaaaac       60

acgagtctcc acacttccct gttcactttg gttccagcat cctgtccagc aaagaagcaa      120

tcagccaaaa tgatacctgg aggcttatct gaggccaaac ccgccactcc agaaatccag      180

gagattgttg ataaggttaa accacagctt gaagaaaaaa caaatgagac ttacggaaaa      240

ttggaagctg tgcagtataa aactcaagtt gttgctggaa caaattacta cattaaggta      300

cgagcaggtg ataataaata tatgcacttg aaagtattca aaagtcttcc cggacaaaat      360

gaggacttgg tacttactgg ataccaggtt gacaaaaaca aggatgacga gctgacgggc      420

ttttagcagc atgtacccaa agtgttctga ttccttcaac tggctactga gtcatgatcc      480

ttgctgataa atataaccat caataaagaa gcattctttt ccaaagaaat tatttcttca      540

attatttctc atttattgta ttaagcagaa attacctttt ctttctcaaa atcagtgtta      600

ttgctttaga gtataaactc catataaatt gatggcaatt ggaaatctta taaaaactag      660

tcaagcctaa tgcaactggc taaaggatag taccaccctc acccccacca taggcaggct      720

ggatcgtgga ctatcaattc accagcctcc ttgttccctg tggctgctga taacccaaca      780

ttccatctct accctcatac ttcaaaatta aatcaagtat tttacaaaaa aaaaaaaa        838


<210>  20
<211>  4102
<212>  DNA
<213>  Homo sapiens

<400>  20
agcctggttg gcagctgcgg cgcagagtcc agccgctggt gcgcggagcg gttcaccgtc       60

ttcggagcgg ttcggcccag cctttcgccc aggcgcccag gcccgctgcg cgcgtgcgtg      120

agcgcgcctg cgccgccggg gccgctgcaa ggggaggaga gaggccgcct caggaggatc      180

ccttttcccc cagaaattac tcaatgctga aacctctcaa agtggtatta gagacgctga      240

aagcaccatg gacgggtttt atgatcagca agtccctttt atggtcccag ggaaatctcg      300

atctgaggaa tgcagagggc ggcctgtgat tgacagaaag aggaagtttt tggacacaga      360

tctggctcac gattctgaag agctatttca ggatctcagt caacttcaag aggcttggtt      420

agctgaagca caagttcctg atgatgaaca gtttgtccca gattttcagt ctgataacct      480

ggtgcttcat gccccacctc caaccaagat caaacgggag ctgcacagcc cctcctctga      540

gctgtcgtct tgtagccatg agcaggctct tggtgctaac tatggagaaa agtgcctcta      600

caactattgt gcctatgata ggaagcctcc ctctgggttc aagccattaa cccctcctac      660

aacccccctc tcacccaccc atcagaatcc cctatttccc ccacctcagg caactctgcc      720

cacctcaggg catgcccctg cagctggccc agttcaaggt gtgggccccg cccccgcccc      780

ccattcgctt ccagagcctg gaccacagca gcaaacattt gcggtccccc gaccaccaca      840

tcagcccctg cagatgccaa agatgatgcc tgaaaaccag tatccatcag aacagagatt      900

tcagagacaa ctgtctgaac cctgccaccc cttccctcct cagccaggag ttcctggaga      960

taatcgcccc agttaccatc ggcaaatgtc agaacctatt gtccctgcag ctcccccgcc     1020

ccctcaggga ttcaaacaag aataccatga cccactctat gaacatgggg tcccgggcat     1080

gccagggccc ccagcacacg ggttccagtc accaatggga atcaagcagg agcctcggga     1140

ttactgcgtc gattcagaag tgcctaactg ccagtcatcc tacatgagag ggggttattt     1200

ctccagcagc catgaaggtt tttcatatga aaaagatccc cgattatact ttgacgacac     1260

ttgtgttgtg cctgagagac tggaaggcaa agtcaaacag gagcctacca tgtatcgaga     1320

ggggccccct taccagaggc gaggttccct tcagctgtgg cagttcctgg tcacccttct     1380

tgatgaccca gccaatgccc acttcattgc ctggacaggt cgaggcatgg agttcaagct     1440

gatagaaccg gaagaggttg ctcggcgctg gggcatccag aagaaccggc cagccatgaa     1500

ctatgacaag ctgagccgct ctctccgcta ttactatgaa aagggcatca tgcagaaggt     1560

ggctggagag cgatacgtct acaaatttgt ctgtgaccca gatgccctct tctccatggc     1620

tttcccggat aaccagcgtc cgttcctgaa ggcagagtcc gagtgccacc tcagcgagga     1680

ggacaccctg ccgctgaccc actttgaaga cagccccgct tacctcctgg acatggaccg     1740

ctgcagcagc ctcccctatg ccgaaggctt tgcttactaa gtttctgagt ggcggagtgg     1800

ccaaacccta gagctagcag ttcccattca ggcaaacaag ggcagtggtt ttgtttgtgt     1860

ttttggttgt tcctaaagct tgccctttga gtattatctg gagaacccaa gctgtctctg     1920

gattggcacc cttaaagaca gatacattgg ctggggagtg ggaacaggga ggggcagaaa     1980

accaccaaaa ggccagtgcc tcaactcttg attctgatga ggtttctggg aagagatcaa     2040

aatggagtct ccttaccatg gacaatacat gcaaagcaat atcttgttca ggttagtacc     2100

cgcaaaacgg gacatagtat gtgacaatct gcatcgatca tggactacta aatgccttta     2160

catagaaggg ctctgatttg cacaatttgt tgaaaaatca caaacccata gaaaagtaag     2220

taggctaagt tggggaggct caaaccatta agggttaaaa atacatctta aacattggaa     2280

agctcttcta gctgaatctg aaatattacc ccttgtctag aaaaaggggg gcagtcagaa     2340

cagctgttcc ccactccgtg gttctcaaaa tcataaacca tggctactct tgggaaccac     2400

ccggccatgt ggtcgccaag tagagcaagc cccctttctc ttcccaatca cgtggctgag     2460

tgtggatgac ttttatttta ggagaagggc gattaacact tttgacagta ttttgttttg     2520

ccctgatttg ggggattgtt ttgttttggt ggttgttttg gaaaaacagt ttataaactg     2580

atttttgtag ttttggtatt taaagcaaaa aaacgaaaaa caaaaaacaa aaacaaacct     2640

tttggtaact gtgcactgtg tcctttagcc agggccgtgc caacttatga agacactgca     2700

gcttgagagg ggctttgctg aggcttcccc ttggccatgt gaaagcccgc cttgttgcct     2760

gctttgtgct ttctgcacca gacaacctga tggaacattt gcacctgagt tgtacatttt     2820

tgaagtgtgc agggcagcct ggacacaagc ttagattctc tatgtatagt tccccgtgtt     2880

cactaacatg ccctctctgg aaagcatatg tatataacat gtgtcatgtc ctttggaaac     2940

ctggtcacct ggtgaaaacc cttgggattc ttccctgggc atgactgatg acaatttcca     3000

tttcatcagt ttgttttgtt ttcctttttc tttaaatctt ggactttaaa ccctacctgt     3060

gtgattcagt agggtttgag acttacgtgt gatactgaca ggtaagcaac agtgctagca     3120

ttctagattc ctgccttttt ttaaaaagaa attattctca ttgctgtatt atattggaaa     3180

agttttaaac aaccaagcta aagctatgtg aaagttgagc tcaaagtaga ggaaaagtta     3240

ctggtggtac cttgctgcct gctctgctgg tagaattctg tgctccccgt gacacttagt     3300

acattaagaa tgactacact gttcctcgta tgtgaaggag gcagtgctga ctccgtgagt     3360

gtgagacacg tgctttgaac tgcttttcta ttcatggagc actccatagt ctcaaactgt     3420

cccccttatg accaacagca catttgtgaa gaggttcgca gggataaggg gtgcacttta     3480

tagctatgga aacatgagat tctcctctat tggaagctaa ttagcccaca aaggtggtaa     3540

acctgtagat tgggccttaa ttagcattgt actctaatca aaggactctt tctaaaccat     3600

atttatagct ttcttaacct acacatagtc tatacataga tgcatatttt acccccagct     3660

ggctagagat ttatttgttg taaatgctgt atagatttgg ttttcctttc tttacttacc     3720

ctggtttgga tttttttttt ttttcttttg aatggattta tgctgtctta gcaatatgac     3780

aataatcctc tgtagcttga gctacccctc ccctgctgta acttacgtga cctgtgctgt     3840

cactgggcat aggacagcgg catcacggtt gcattcccat tggactcatg cacctcccgg     3900

atggtttttg tttttttcgg gggttctttg gggtttgttt gtttgcttct tttccagagt     3960

gtggaaagtc tacagtgcag aaaggcttga acctgccagc tgatttgaaa tactttcccc     4020

tgcgcagggc cgtatgcatc ctgccaagct gcgttatatt ctgtactgtg tacaataaag     4080

aagtttgctt ttcgtttacc aa                                              4102


<210>  21
<211>  12408
<212>  DNA
<213>  Homo sapiens

<400>  21
ctcacaacca gccgactctc ccattatcca gctgcctagt ttggtgcttc aatgtacatg       60

gctattccgt gtgcatatgt gtgtatacaa acacgcatgc atgcctggat ggacatacgt      120

atgcacaggt tattttttaa ggacaattct ttcaataagg tctttacccc ttacttgaaa      180

caggtgttca tgaaaaaaat gcacaaaatc ctgcctggcc ggaataattc atgaagaagg      240

ggctggatcc gtgggtcaga gaacacagga ccagtttgcc atcccaaggc cgaaggcctc      300

cctccaacac agttctccaa gctctagaaa tctctgacac atcttgacca tgagaccacg      360

gctggttttt ggcaggattc gaggcacaaa cccagcagcc tcaacctagt tcatggagga      420

gcctcgcggg gtcctggcca agcaagcccg cccctctggt gggaagagcg gcgcctaggt      480

ggagggtggc tgccgtagga gtggacatga atgctggctt tcagagagaa cagcgtttca      540

gttttggtca tcggaagtgg tgccttcagc acagaagaag agcgtgattt ctcctccaag      600

gccgttgatc tccaacccag aactaaaggg gagaagagcc acccccagca tccagcgtgg      660

catctcttgt gccaggacca gggatgactg ggccatggac acagatgtct ccaaccttca      720

accgtttgca tagcacacgg gggactcgtg ggggccacct gccactgcca gctgaaacaa      780

tacaatggca atactgacat ccttcatgac gttttcccga cagacattca ggcagaaagt      840

gctggtgcgt tttctgtctg caaagtagag ggccatgcct caccaataga atagcgtggg      900

ccctgatgac ctgctccgag tccactcaca gccagtgaca cttgcaaaaa actcccaaag      960

ccgtcttggg tttggctccc acagctcttg accaatgtgg ccaaagctgg acacctcctt     1020

gggacactgg gattattcat aaatgcagcc cgccctgact ctccctgaat agcatctgaa     1080

gtctttgtga aggtcatgga tcctgaacaa agtgtcaagg gcaccaagaa ggctgaggga     1140

agtccccgga agcggctgac caaaggagag gccattcaga ccagtgtttc ttccagcgtc     1200

ccatacccag gcagcggcac agctgccacc caagagagcc ccgcccaaga gctcttagcc     1260

ccgcagccct tcccgggccc ctcatcagtt cttagggaag gctctcagga gaaaacgggc     1320

cagcagcaga agccccccaa aaggcccccc atcgaagcat ccgtccacat ctcacagctt     1380

ccgcagcacc ctctgacacc agcattcatg tcgcctggca aacctgagca tctcctggag     1440

gggtccacat ggcaactggt tgaccccatg agacctggac cctctggctc cttcgtggcc     1500

cctgggctcc atcctcagag ccagctcctt ccttcccacg cttccatcat tccccccgag     1560

gaccttcctg gagtccccaa agtcttcgtg cctcgtcctt cccaggtctc cttgaagccc     1620

acagaagagg cacacaagaa ggagaggaag ccccagaagc caggcaagta catctgccag     1680

tactgcagcc ggccctgtgc caagcccagc gtgctccaga agcacattcg ctcacacaca     1740

ggtgagaggc cctacccctg cggcccctgt ggcttctcct tcaagaccaa gagtaatctc     1800

tacaagcaca ggaagtccca tgcccaccgc atcaaagcag gcctggcctc aggcatgggt     1860

ggcgagatgt acccacatgg gctggagatg gagcggatcc ctggggaaga gtttgaggag     1920

cccactgagg gagaaagcac agattctgaa gaggagacta gtgccacctc tggtcaccct     1980

gcagagctct ccccaagacc caagcagccc cttctctcca gcgggctata cagctctggg     2040

agccacagtt ccagccacga acgctgttcc ctgtcccagt ccagcacagc ccagtcactc     2100

gaagaccccc ctccatttgt ggaaccctca tctgagcacc ccctgagcca taaacctgaa     2160

gacacccaca cgattaagca gaagctggcc ctccgcttaa gcgagaggaa gaaggtgatc     2220

gatgagcagg cgtttctgag cccaggcagc aaagggagta ctgagtctgg gtatttctct     2280

cgctccgaga gtgcagagca gcaggtcagc cccccaaaca ccaacgccaa gtcctacgct     2340

gagatcatct ttggcaagtg tgggcgaata ggacagcgga ccgccatgct gacagccacc     2400

tccacccagc ccctcctgcc cctgtccacc gaagacaagc ccagcctggt gcctttgtct     2460

gtaccccgga cgcaggtgat cgagcacatc acgaagctca tcaccatcaa cgaggccgtg     2520

gtggacacca gcgagatcga cagcgtgaag ccaaggcgga gctcactgtc caggcgcagc     2580

agcatggagt ccccaaaatc cagcctctac cgggagcccc tgtcatccca cagtgagaaa     2640

accaagcctg aacaatcact gctgagcctc cagcacccgc ccagtaccgc cccccctgtg     2700

cctctcctga gaagccactc aatgccttct gccgcctgca ctatcagcac cccccaccac     2760

cccttccgag gtagctactc cttcgatgac catatcaccg actccgaagc cctgagccac     2820

agcagtcacg tgtttacctc ccacccccgg atgctgaagc gccagccggc aatcgaatta     2880

cctttgggag gggaatacag ttctgaggag cctggcccaa gcagcaaaga cacagcctcc     2940

aagccctcgg acgaagtgga acccaaggaa agcgagctta ccaaaaagac caagaagggt     3000

ttgaaaacaa aaggggtgat ctacgaatgt aacatatgtg gtgctcggta caagaaaagg     3060

gataactacg aagcccacaa aaaatactac tgctcagagc ttcagatcgc aaagcccatc     3120

tctgcaggca cccacacatc tccagaagct gaaaagagtc agattgagca tgagccgtgg     3180

tcccaaatga tgcattacaa actgggaacc accctggaac tcactccact gaggaagagg     3240

aggaaagaga agagccttgg ggacgaggaa gagccacctg cctttgagtc cacaaaaagt     3300

cagtttggca gccccgggcc atctgatgct gctcggaacc ttcccctgga gtccaccaag     3360

tcaccagcag aaccaagtaa atcagtgccc tccttggagg gacccacggg cttccagcca     3420

aggactccca agccagggtc cggttcagaa tcagggaagg agaggagaac aacgtccaaa     3480

gaaatttctg tcatccagca caccagctcc tttgagaaat ctgattctct cgagcagccg     3540

agtggcttgg aaggggaaga caaacctctg gcccagttcc catcaccccc acctgcccca     3600

cacggacgct ctgctcactc cctgcagcct aagttggtcc gccagcccaa cattcaggtt     3660

cctgagatcc tagtaactga ggagcctgac cggccggaca cagagccaga gccgccccct     3720

aaggaacctg agaagactga ggagttccaa tggccccagc gcagccagac acttgcccag     3780

ctcccagctg agaagctgcc acccaaaaag aagaggttgc gcctggcaga gatggcccaa     3840

tcatcagggg agtccagctt cgagtcctct gtgcctctgt ctcgcagccc gagccaggaa     3900

agcaatgtct ctttgagtgg gtccagccgc tcagcctcgt ttgagaggga tgaccatggg     3960

aaagccgagg cccccagtcc ctcatctgac atgcgcccca aacccctggg cacccacatg     4020

ttgactgtcc ccagccacca cccacatgcc cgagagatgc ggaggtcagc ctcagagcag     4080

agccccaacg tttcccattc tgcccacatg accgagacac gcagcaaatc ctttgactat     4140

ggcagcttgt ccttgacagg cccttctgct ccagccccag tggctccacc agcgcgggtg     4200

gccccgccag agagaagaaa atgcttcttg gtgagacagg cctctctgag caggcctcca     4260

gaatctgagt tggaggttgc ccccaaggga agacaggaga gcgaagaacc acagccctca     4320

tccagtaaac cctctgccaa aagctcattg tcccagattt cctctgcggc cacctcacat     4380

ggtggacccc cgggaggcaa gggcccaggg caggacaggc ccccattggg gcccactgtg     4440

ccctacacag aagcactgca agtgttccac caccccgttg cccagacacc cctgcatgag     4500

aagccatacc tgcccccacc agtctccctt ttctccttcc agcatctcgt gcagcatgag     4560

ccaggacagt ctccagaatt cttctccacc caggccatgt ccagcctcct gtcctcacca     4620

tactccatgc ccccacttcc tccctcctta tttcaagccc caccgcttcc tctccagcct     4680

actgttctgc acccaggcca actccatctc ccccagctca tgcctcaccc agccaacatc     4740

cccttcaggc agcccccttc cttcctcccc atgccatacc cgacctcctc agcactgtct     4800

tctgggtttt tcctgcctct gcaatcccag tttgcacttc agctccctgg tgatgtggaa     4860

agccatctgc cccagatcaa aaccagcctg gccccactgg caacaggaag tgctggcctc     4920

tcccccagca cagagtacag cagtgacatc cggctacccc ctgtggctcc cccagccagc     4980

tcctcagcac ctacatcagc tcctccactg gccctgcctg cctgtccaga caccatggtg     5040

tccctggttg tgcctgtccg tgttcagacc aatatgccgt cctatgggag cgcaatgtac     5100

accacccttt cccagatctt ggtcacccag tcccaaggca gctcagcaac tgtggcactt     5160

cccaagtttg aggaaccccc atcaaagggg acgactgtat gtggtgcaga tgtgcatgag     5220

gttgggcccg gcccttctgg gttaagtgaa gagcaaagca gagctttccc aactccatac     5280

ctgagagtgc ctgtgacatt acctgaaaga aaaggcactt ccctgtcatc agagagtatc     5340

ttgagcctgg aggggagttc atcaacagca gggggaagca aacgtgtcct ttcaccagct     5400

ggcagccttg aacttaccat ggaaacccag cagcaaaaaa gagtgaagga ggaggaggct     5460

tccaaggcag atgaaaaact tgagctggta aaaccatgca gtgtggtcct taccagcacc     5520

gaggatggga agaggccaga gaaatcccac ttaggcaacc agggccaagg caggagggag     5580

ctagaaatgc tgtccagcct gtcctcagat ccatctgaca caaaggaaat tcctcccctc     5640

cctcaccctg cattgtccca tgggacagcc ccaggctcag aagctttgaa ggaatatccc     5700

cagccatctg gcaaacctca ccgaagaggg ttgaccccac tgagcgtgaa gaaagaagat     5760

tccaaggaac aacctgatct cccctccttg gcacctccga gctctctgcc tctgtcagaa     5820

acgtcctcca gaccagccaa gtcacaagaa ggtacggact caaagaaggt actgcagttc     5880

cccagcctcc acacaaccac taatgtcagt tggtgctatt taaactacat taagccaaat     5940

cacatccagc atgcagatag gaggtcctct gtttacgctg gttggtgcat aagtttgtac     6000

aaccccaacc ttccgggggt ttccactaaa gctgctttgt ccctcctgag gtctaagcag     6060

aaagtgagca aagagacata caccatggcc acagctccgc atcctgaggc aggaaggctt     6120

gtgccatcca gctcccgcaa gccccgcatg acagaggttc acctcccttc actggtttcc     6180

ccggaaggcc agaaagatct agctagagtg gagaaggaag aagagaggag aggggagccg     6240

gaggaggatg ctcctgcctc ccagagaggg gagccggcga ggatcaaaat cttcgaagga     6300

gggtacaaat caaacgaaga gtatgtatat gtgcgaggcc gcggccgagg gaaatatgtt     6360

tgtgaggagt gtggaattcg ctgcaagaag cccagcatgc tgaagaaaca catccgcacc     6420

cacactgacg tccggcccta tgtgtgcaag cactgtcact ttgcttttaa aaccaaaggg     6480

aatctgacta agcacatgaa gtcgaaggcc cacagcaaaa agtgccaaga gacaggggtg     6540

ctggaggagc tggaagccga agaaggaacc agtgacgacc tgttccagga ctcggaagga     6600

cgagagggtt cagaggctgt ggaggagcac cagttttcgg acctggagga ctcggactca     6660

gactcagacc tggacgaaga cgaggatgag gatgaggagg agagccagga tgagctgtcc     6720

agaccatcct cagaggcgcc cccgcctggc ccaccacatg cactgcgggc agactcctca     6780

cccatcctgg gccctcagcc cccagatgcc cccgcctctg gcacggaggc tacacgaggc     6840

agctcggtct cggaagctga gcgcctgaca gccagcagct gctccatgtc cagccagagc     6900

atgccgggcc tcccctggct gggaccggcc cctctgggct ctgtggagaa agacacaggc     6960

tcagccttga gctacaagcc tgtgtcccca agaagaccgt ggtccccaag caaagaagca     7020

ggcagccgtc caccactagc ccgcaaacac tcgctaacca aaaacgactc atctccccag     7080

cgatgctccc cggcccgaga accacaggcc tcagccccaa gcccacctgg cctgcacgtg     7140

gacccaggaa ggggcatggg cgctctccct tgtgggtctc caagacttca gctgtctcct     7200

ctcaccctct gccccctggg aagagaactg gcccctcgag cacatgtgct ctccaaactc     7260

gagggtacca ccgacccagg cctccccaga tactcgccca ccaggagatg gtctccaggt     7320

caggccgagt caccaccacg gtcagcgccg ccagggaagt gggccttggc tgggccgggc     7380

agcccctcag cgggggagca tggcccaggc ttggggctgg acccacgggt tctcttcccg     7440

cccgcgcctc tacctcacaa gctcctcagc agaagcccag agacctgcgc ctccccgtgg     7500

cagaaggccg agtcccgaag tccctcctgc tcacccggcc ctgctcatcc tctctcctcc     7560

cgacccttct ccgccctcca tgacttccac ggccacatcc tggcccggac agaggagaac     7620

atcttcagcc acctgcctct gcactcccag cacttgaccc gtgccccatg tcccttgatt     7680

cccatcggtg ggatccagat ggtgcaggcc cggccaggag cccaccccac cctgctgcca     7740

gggcccaccg cagcctgggt cagtggcttc tccgggggtg gcagcgacct gacaggggcc     7800

cgggaggccc aggagcgagg ccgctggagt cccactgaga gctcgtcagc ctccgtgtcg     7860

cctgtggcta aggtctccaa attcacactc tcctcagagc tggagggcgg ggactacccc     7920

aaggagaggg agaggaccgg cggaggcccg ggcaggcctc ctgactggac accccatggg     7980

accggggcac ctgcagagcc cacacccacg cacagcccct gcaccccacc cgacaccttg     8040

ccccggccgc cccagggacg ccgggcagcg cagtcctgga gcccccgctt ggagtccccg     8100

cgtgcaccga ccaaccccga gccttctgcc accccgccgc tggaccgcag cagctctgtg     8160

ggctgcctgg cagaggcctc tgcccgcttc ccagcccgga cgaggaacct ctccggggaa     8220

cccaggacca ggcaggactc ccccaagccc tcaggaagtg gggagcccag ggcacatcca     8280

catcagcctg aggacagggt tccccccaac gcttagcctc tctccaactg cttcagcatc     8340

tggcttccag tgtccagcaa cagacgtttc cagccacttt cctcgaatca tcccacttcc     8400

tcagccccat ctgtccctcc gtccaggagc tctcacggcc ccatctgttg taccttccca     8460

tgtatgcagt tacctgtgcc tttttctaca ccttttgttg cttaaaaaga aacaaaacaa     8520

atcacataca tacatttaaa aaaaaaacaa caacccacga ggagtctgag gctgtgaata     8580

gtttatggtt ttggggaaag gctgatggtg aagcctcctg accctccccg ctgtggttgg     8640

cagccaccca ccccagaggc tggcagaggg aaaggggtac actgagggag aaaggaaaag     8700

gaaacttcaa acaatataga attaaatgta aaaggaagca ctcctgtgta cagatgcgat     8760

caaggttcct gtttattgcc acttcacccc cctgcccagc tcgtagccac ccctctctgc     8820

cagcagaaag gccagtgtcc ccaggcagag gggcacaaac acaggcaggt gacccccacc     8880

caggccccag caggcaggcc cagaaaaact aatcttttcc tttttttttt tttttttttt     8940

ttttgcaaga aaataaaatg atacttttcc taggatttca acacaaaata ataggtgcag     9000

gtagaaggag gagggctggc tccccaaggg ctcctggata ctctggtagt ctgagtcatg     9060

ggcccatcct ggcactccac aggtgggcag gccaccccac ccacgcaccc ccactccaga     9120

cacctccctt ctgcacccca ccctggcccc ctgggctggg gaaggagccc tgactgtccg     9180

tccctggctc ccaagcccct gaccgaggcc tcactctcct gttgcctcct ctgttctaaa     9240

accaccaaac cacccacaaa ggcagaagtg gcagggcccg agccctagcg gccgttcctg     9300

agactgggtt ttgggttttg tttcatcttg gtccctgggg tacaagggag cctgttcccc     9360

tcatggctgg gtttttccag ttctccacag cagaggtttg cggggaactg tttcaggacc     9420

actttgccac aggaccgttt ccccccgtcc ctgcccctgt ctccactacc ccaaggaaat     9480

acccacaact gtggctggtg gatacggcct ggacctgttt gctgtcttac acctcttttt     9540

taaaaagaga gaggatggtg tttgatactt cacccagcca ccacagattc ttttgaccta     9600

gaggattttt gaattgtcct aactcgttgg aattctccaa agcaatcagt gtgagccagt     9660

gcctcttcct tacccacatc tctactttca agaagctgcc ctgcatttcc tggggcaaaa     9720

ctctactttg taagaaaaat aataggacca gaaatttaaa tcccaaattg aactatggaa     9780

cttgaactct agcgtgttcg ccccaactgg gagaggtgag ctttttccca gtgtttcaga     9840

actgattttc tttactttct acaagggagg gcagcacagg gactacggtt gaggcccgtg     9900

aaggctgggt ttgatgccac cctatacaga gcagggacct ctctggctaa tccccagtcc     9960

tcagccaggc tgtgtgaatc aagtgcctgc cccagggctc ttgagctatt gaagctgctt    10020

gggtacagga cacagtaggt ggggagggtt aagacccttc tgtgagttcc ctgtgcgggg    10080

ctgtacttgc ctcttccaat tcgtggcctt tccctgcttg gtccctacta gacagacaaa    10140

ccagccacag tccagcctgc agccagacca ccttgttcac tcattctcct ttgcctcaga    10200

gctaagacaa aaatgagaca gaaggcaggg ctccctggga gtccactgtg ctccagggtt    10260

ctggggaatc agggttagcc agcagctcct ggctgcttcc ctcagagact agggctctca    10320

tcctccccaa gagaagcagc aagcccagcc tggaccacac tgtccatatt gctggacagt    10380

ggcctgacag aaagtgactc ctccaagtcc caggaggcca gggcttttct catccttgcc    10440

tttcagccct aacccatggg actgcccacg gattggagac ttcaagggct gaggtctggg    10500

agctgcataa agggcattgc ttcagcccag gttagaaatc tgcctgggca agctcttcct    10560

gccccagacc tacaaagcag cagaccgggg gctctggtgg actagcccct gacattggtg    10620

gggggcccca caccactcca ccccaccctg ccttccagct ctcctgggca tttttctccc    10680

tgtactcaaa cagcctaccc acccaaggtt tcctccctgg gcagcctagc aatgaacagt    10740

gcagccggca gggcagaggc ccggcagtca ccgggcccgt caggctcagg cagagaagcc    10800

acaggggcca ggagtcactg gagactattt ctaaatgatg ggggtaaatg cacaaataga    10860

atctcaccaa agggctgcct ccacattgat gccgtgccca gagggacaga accaatgcca    10920

ccagcctggg tatatgtcac tgggcacagc tctaaccccc tcctccggac tctagtcccg    10980

ctcctctgcg cacagagccc ccagcccaca ggtacacctt catgatttgg agaaagacgc    11040

tcgccccatg cacgccctcc tctgggcctt ctgccctgct cccagtcact tccaagcttc    11100

ctgtttgcct gtgatgttat tgtgcctgtt gagggaagca gcagaggagg cagtggctga    11160

cttggcacag atgcctgcta cgtgctctgt tgaaatgcgc ggggtggcca ttcctcggta    11220

cagactagtc ctggtccttg ggtgtgggca gtgggggagg aaccaactgg tcgaggtttc    11280

agagccaaac cttgcctttg gttggtgagt ccttgccccc caggcctgcg ctccacgatg    11340

cctttcaccc ttggcaatct cagggccatc ctgggtagta accccactcc tctctgctcc    11400

cgcccgcacc tgtggctctc actctgggct caacccctgc aaccctccag gagcccgaca    11460

gcagccagct gcctgcactg tcgcctccgt aagctccaac ttccagaccc agaagtccct    11520

ctgcttccct ctgttggaaa aagcctaaaa gaattagctt ccagattcct ctagcccctg    11580

ctccattccc acccagtcct tctgaagagg aatgagcaat acatctgagc tggatttctc    11640

tctagtcctt tctccagaca aatccttctt aaagcaaaag tcctggctga gcacctgtcc    11700

ttggggaccg atctgccgtg tgaccagggg aagaaagttc ccgaaagcct gttccaccaa    11760

ttctgcttct gtgttgtgaa tccagtctgc tttccattag aaaaccgctt cggcacttat    11820

ggtcacttta ataaatctag tatgtaaaaa aagaaagaaa gaaaagaaac agaaaaaaga    11880

aacgtgcagg caaatgtaaa atacaatgct ctctgtaaga taaatatttg cctttttttc    11940

taaaaggtgt acgtattctg tatgtgaaat tgtctgtaga aagtttctat gttcttaaat    12000

ggcaatacat tccaaaaatt gtactgtaga tatgtacagc aaccgcactg ggatggggta    12060

gttttgcctg taattttatt taaactccag tttccacact tgcatcttgc aatgttggta    12120

tggtatatat cagtgcaaaa gaaaaaacaa aacagaaaca aacaaaaaaa aaaaacaaaa    12180

atccacgcag gtctaaagca cagagtctga cgtacaaaag gaaaaatgct cagtattgat    12240

gtgtgtgacc tttgttgtaa attacatctg tactgtgaat gagaagtttt tacaagtata    12300

ataattgcct ttattacagc tctggctgag tgttcagcct gaggatattt tttaaaaaaa    12360

aaagaattag catgttggaa taaatttgaa aatcccaaca taaaaaaa                 12408


<210>  22
<211>  3257
<212>  DNA
<213>  Homo sapiens

<400>  22
tctcactagc ctcagagcac tctcagaagt tcagaaacta agaccagaaa agagaagatt       60

tttagacagc tcatgaaacg gtctgcgcgg ggcggccatt ggcggcggag tgtcacgtga      120

ccgcgggggc gtgccaatgt gcgccctcac gggtgtcaaa cccctgtcag agtgtgcgat      180

caagatcgtg aaacaacgcg atgcaaaaag cgacctacta cgacagctcg gcgatctacg      240

gtggctaccc ctaccaggca gccaacgggt tcgcttataa tgccaatcag cagccgtacc      300

cggcgtccgc cgctttgggc gccgacggcg agtaccaccg acccgcctgc tccctccagt      360

ctccctccag cgccgggggc caccccaagg cacacgaact gagtgaggcg tgcctgcgca      420

ccctgagcgc cccacctagc cagcctccaa gcctgggaga gccgcccctg cacccgccgc      480

cgccccaggc cgcgccccct gccccacagc cgcctcagcc cgcacctcag ccccctgcac      540

ctacccctgc cgcgcccccg cctccctctt ctgcctcccc tcctcagaat gccagcaaca      600

accctacccc tgccaacgcg gccaagagcc ccctgctcaa ctcacccaca gtggccaaac      660

aaatcttccc ctggatgaaa gagtctcgac aaaacacaaa gcagaaaacc agcagctcca      720

gctcaggcga aagctgcgct ggcgacaaga gcccgccggg gcaggcttcg tccaagcgcg      780

cgcgcacggc ctacacgagc gcgcagctgg tggagctgga gaaagagttc cacttcaacc      840

gctacctgtg ccggccgcgc cgggtggaga tggccaatct gctgaacctc actgagcgcc      900

agatcaagat ctggttccag aatcgccgca tgaagtacaa aaaggatcag aagggcaagg      960

gcatgctaac gtcatcgggg ggccagtctc caagtcgcag ccccgtgccc cccggagccg     1020

gtggctatct gaactctatg cattcgctgg tcaacagcgt cccgtatgag ccccagtcgc     1080

ccccgccctt ctccaagccc ccccagggta cctacgggct gccccccgcc tcctaccctg     1140

cgtccctgcc cagctgcgca cccccgccac ccccacagaa gcgctacacg gcggcagggg     1200

cgggcgcagg gggcaccccc gactatgacc cgcacgctca tggcctgcag ggcaacggca     1260

gctatgggac cccacacata cagggaagcc ccgtcttcgt ggggggcagc tatgtggagc     1320

ccatgagcaa ctccgggcca gccctctttg gtctaactca cctcccccac gctgcctcgg     1380

gcgccatgga ctatgggggt gccgggccgc tgggcagcgg ccaccaccac gggccggggc     1440

ctggggagcc gcaccccacc tacacggacc ttaccggcca ccatccttct cagggaagaa     1500

ttcaggaagc acccaagctc acccacctgt gatagtgggc ttggggctac gcgccaggag     1560

agtctccccc cacccacctt ttttctttgg ttgctttttt tttttttttt ttttaggttc     1620

ttcctgccct ttccttcctt ccttttctct cttctccgcc ccgcactccg tttcccggtt     1680

tcccccctcg ttggtaaggc gtttttatag tttatgtgac gtagcaatct tggttgctgg     1740

aatggctgta tcatagcgat atttatctct tcctgctcct cgataggcca ctggccctgc     1800

accctttacc ttctccactc tttgatcaga aacagggtat atgaacaaat tttctagtcg     1860

agttttcaat gtgaatttgt tcttacatta tggctcccga ggggaagcga ttactttttt     1920

taattttaaa tttttttttt aattgcactt cttgtaaaga gtgagaaaaa aaatcaaagg     1980

cgctttgaaa caggggctct ctgtgcaagg atgactaagt gtacgtcttt ccgtgtgtgt     2040

atgctggtga acagtcagat ttatttatat ttttttgcaa gcattgaata atctaagttt     2100

taaatattat ttatccccat ccgttcgtat ttatattaaa gaattctgta ccctgatggt     2160

tcagaagggt tcttgggcct tttgttcaat tgtgtattgg cgtacttaga atttttttta     2220

tttgaaagag aaatataatt cctttaaacg gtaacgatac aataaaacca gagaagatcc     2280

agcttttgaa aacagtgatt taggtttgta acatccggca aaactgaaaa aaaaaatctg     2340

taaacgcgaa aaatactaga tttgttttga gagttcttca ttccttgctg ctcacattct     2400

gagaaacaaa aagaaataaa gtttttattc tgaataatat ccgtgttaag aaggggttct     2460

ttggccgaag acgtgggtct gcgtggaatt caggccgagg cgagccggca gagcaggccg     2520

gacgcagcag ccctctggct ccagcatggg gcctggccag gctattcgcc tggaagctcg     2580

gcgaattctc aggatggcgg ctggggctcc aggcggctgc ggcagctctg gtaacgccgt     2640

gcggcgggcc agctgggctg cccggttccc agctgctgcg gaggcaggct gagggcgcag     2700

gggctgccga gtgctgtgca cggaagaaac aaagacatcc cggcccaagg cgcagcggga     2760

gcgcacaggt gccccgcggc ccagccgggg gataacgcag ggcggtcttc tgctccatgc     2820

tcttcctcgg gtcaaagcgg accaactaac gcctaaacct cggtattagc cagccgcgca     2880

gaggatgccg agcactttcc gggagcaatc ggactcctgg tctcctccgg ggatgcttcg     2940

cggtctgtta tcgcgtcagg aggaaagaat tgctccaaaa atctgcacgc ggagcgaaac     3000

agtttgaaag ggactgaggc tcacccaggt ctccagcaaa cggaggactg aactggggag     3060

agtcaccctg agccagccct tccctggact gccggaatcc cagcattagc ttcctgctga     3120

atgtagtatt tggcattctc tgaatttatt tcctctcctt cccccaccca gctttctttt     3180

tatggcccca gggggagggg gagagagcaa ggagatcggt atctttgtaa taaaactgca     3240

attttataaa tttttca                                                    3257


<210>  23
<211>  1657
<212>  DNA
<213>  Homo sapiens

<400>  23
gggtgctata gacgcacaaa cgaccgcgag ccacaaatca agcacacata tcaaaaaaca       60

aatgagctct tattttgtaa actcattttg cggtcgctat ccaaatggcc cggactacca      120

gttgcataat tatggagatc atagttccgt gagcgagcaa ttcagggact cggcgagcat      180

gcactccggc aggtacggct acggctacaa tggcatggat ctcagcgtcg gccgctcggg      240

ctccggccac tttggctccg gagagcgcgc ccgcagctac gctgccagcg ccagcgcggc      300

gcccgccgag cccaggtaca gccagccggc cacgtccacg cactctcctc agcccgatcc      360

gctgccctgc tccgccgtgg ccccctcgcc cggcagcgac agccaccacg gcgggaaaaa      420

ctccctaagc aactccagcg gcgcctcggc cgacgccggc agcacccaca tcagcagcag      480

agagggggtt ggcacggcgt ccggagccga ggaggacgcc cctgccagca gcgagcaggc      540

gagtgcgcag agcgagccga gcccggcgcc gcccgcccaa ccccagatct acccctggat      600

gcgcaagctg cacataagtc atgacaacat aggcggcccg gaaggcaaaa gggcccggac      660

ggcctacacg cgctaccaga ccctggagct ggagaaggag ttccacttca accgttacct      720

gacccgcaga aggaggattg aaatagcaca tgctctttgc ctctccgaga gacaaattaa      780

aatctggttc caaaaccgga gaatgaagtg gaaaaaagat aataagctga aaagcatgag      840

catggccgcg gcaggagggg ccttccgtcc ctgagtatct gagcgtttaa agtactgagc      900

agtattagcg gatcccgcgt agtgtcagta ctaaggtgac tttctgaaac tcccttgtgt      960

tccttctgtg aagaagccct gttctcgttg ccctaattca tcttttaatc atgagcctgt     1020

ttattgccat tatagcgcct gtataagtag atctgctttc tgttcatctc tttgtcctga     1080

atggctttgt cttgaaaaaa aatagatgtt ttaacttatt tatatgaagc aagctgtgtt     1140

acttgaagta actataacaa aaaaagaaaa gagaaaaaaa aacacacaaa aagtccccct     1200

tcaatctcgt ttagtgccaa tgttgtgtgt tgcactcaag ttgtttaact gtgcatgtgc     1260

gtggaagtgt tcctgtctca atagctccaa gctgttaaag atatttttat tcaaactacc     1320

tatattcctt gtgtaattaa tgctgttgta gaggtgactt gatgagacac aacttgttcg     1380

acgtgtagtg actagtgact ctgtgatgaa aactgtgact ccaagcggtg tgtccctgcg     1440

tgcctttata ggaccctttg cacgaactct ggaagtggct cttataagcg cagcttcagt     1500

gatgtatgtt tttgtgaaca aagttacaaa tattgtccaa gtctggctgt tttaagcaaa     1560

ctgtgatcag cttttttttt tttttttttt tttttgtatt tgtttttaag gaaaaaatac     1620

tgactggaac aaaaaataaa ctttctattg taagttc                              1657


<210>  24
<211>  3627
<212>  DNA
<213>  Homo sapiens

<400>  24
ctgggtaggg cagggggaac cgacaggccg gtgtccccag ccgcaaaaga gctgctgaac       60

tgtccgttta aatgctgctg ggagactcgt aaaaaaatca tcgtggacct ggaggatgag      120

aggggcgagc tttatttcgg tcggattgcg gtgtggtggt ttagctgcaa ggggatgccg      180

cagccccagt tgagggggaa aatagttctt aaaaagcata tgccccccta aggaatgtct      240

ctaaagaacc aaatcaaagc tgctctttgg aaggtatgaa tagaatttaa aaaaaaaaga      300

tttctatgga gcttaaagtt cacagccatt ctgtgtagac aagagctaag aaaaatgtga      360

gaattataca gaaaaccatt aatcacttct tttctttaaa tacgtatcct ctctcctttg      420

ttattattca acagcaaatc tccttggacc ggctgttggg ggaaaaaagt gttagccgtc      480

tctcccggat ctgcaagggg gaaaaaattt ggaaccataa agttgaaaac ttttttctct      540

cagtttggaa gaagcccttc gtcatgaatg ggatctgcag agttcgggcg agaggaggcg      600

agaggcgcaa aggaggggag atttgtcgcc tgccgctcgc tctggggctc gatgtgaata      660

tatattatgt ctgcctgttc tcccctcgtc ggtggctaag gtcagccgct tggaacagac      720

cccggaggag gggggcagag aggggaggtg gggggggggg gtccggcgtg tcacgtgacc      780

cccagggttg ccaatgtccg gtcctgaggg tatcaggcct ttccaagttg ccacccactg      840

cccaggcctc acccagcgat gcagaaagcc acctactacg acaacgccgc ggctgctctc      900

ttcggaggct attcctcgta ccctggcagc aatggcttcg gcttcgatgt ccccccccaa      960

cccccatttc aggccgccac gcacctggag ggcgactacc agcgctcagc ttgctcgctg     1020

cagtccctgg gcaacgctgc cccacatgcc aagagcaagg agctcaacgg cagctgcatg     1080

aggccgggtc tggcccccga gcccctgtcg gccccgcctg gctcaccccc gcccagtgcc     1140

gcacctacca gtgccactag caacagcagt aatgggggcg ggcccagcaa aagtggtccc     1200

ccaaagtgcg gtcccggcac caactccacc ctcaccaaac agatattccc ctggatgaaa     1260

gagtcgaggc aaacgtccaa gctgaaaaac aactcccccg gcacagcaga gggctgtggt     1320

ggcggcggcg gtggcggcgg cggcggaggc agtggtggca gcgggggcgg tggcggcggc     1380

ggcgggggag gggacaagag ccccccgggg tcggcggcgt ccaagcgggc gcggacggcg     1440

tacacgagcg cgcagctggt ggagctggag aaggagttcc attttaaccg ctacctgtgc     1500

cggcctcgcc gtgtagagat ggccaacctg ctgaacctca gcgagcggca gatcaagatc     1560

tggttccaga accggcgcat gaagtacaag aaggaccaga aggccaaggg attggcctcg     1620

tcgtcggggg gcccatctcc agccggcagc cccccgcagc ccatgcagtc cacggccggc     1680

ttcatgaacg ccttacactc catgaccccc agctacgaga gcccgtcccc acccgccttc     1740

ggtaaagccc accagaatgc ctacgcgctg ccctccaact accagccccc tctcaaaggc     1800

tgcggcgccc cgcagaagta ccctccgacc ccggcgcccg agtatgagcc gcacgtcctc     1860

caagccaacg ggggcgccta cgggacgccc accatgcagg gcagtccggt gtacgtgggc     1920

gggggcggct acgcggatcc gctgccgccc cctgccggcc cctccctcta tggcctcaac     1980

cacctttccc atcacccttc cgggaacctg gactacaacg gggcgccccc tatggcgccc     2040

agccagcacc acggaccctg cgaaccccac cccacctaca cagacctctc ctctcaccac     2100

gcgcctcctc ctcagggtag aatccaagaa gcgcccaaat taacacacct gtgatgggaa     2160

agggcgaacg aggattaggg gatggggagg aagagagaga ctgtggagct ctggggggca     2220

acctggaggt ctgaaaagag gagccagaga aggtggtacc caggcttcct ggtcagaacc     2280

ggcctggagc tccttccctt ccccctggcc tgagaggttg cttttaagtc ttccacccct     2340

tgttccatct gcctgccaac ccatcggaaa ggaatccaca tcatattgga gatgacccca     2400

tcaaccccag ggctccagca ctaccaagtt ggaattccac gcccgggagt ggggtagagg     2460

aagacgagac aggacgaggc agaaaagcac attttaaaaa ccagacaaga tggctaggcc     2520

atcaccaacc aacggactta ccttacatct ttgtaggtaa ttccccccaa atcttgattt     2580

ttttttttcc tcaattatcc tttaaaaaat aagaaaacac atttcaaacc caaaaggcac     2640

aaaacacgtt cccttccaac tttcccaaaa cctcaaattt gttcccattt gaggtttatt     2700

gaggtacact tctagccccc ggtttttctg ctctagaaca ttcatatcta tacatcccac     2760

ccccatcaat tacagttttt agagggctca gggatggtga gagatcctga aagagctgcc     2820

tatattataa attatataca ttttttttta aggaaaagtg tggaggctag ggcaggcagg     2880

ttgttaggac tgaaggtttg cccattctgc tgcctccatc tcagctccag ctccatcccc     2940

ctctccacag aaagcagttg gtgacacgag gttctatact tttcttctgt tgctctcttg     3000

acttaacgtg aaaacagggt atatttgaac aaactgtccc aggcaggggc tgggcagggc     3060

ctgtgtgcct tgctcagcct cctgacagga cacttttgtt gcacttagaa tttacatttt     3120

aatggatgta aaaacaactg tgagagatgt ctgggcctgc agaagtccag cattgctcaa     3180

aaaagcgtgt gttctagtga acattttcat atatatttat tggttatagc ctgttaaaat     3240

attttctttt ttgtattatt tatcccccta cattatgtat ttatatgagg gaaaaaaagg     3300

aaaaaattgt acttttttag tatttacctg ttacaaagga cattgtgttt cctgtcatgt     3360

aaaaccagct attttagtta ctattgtact ctagaaaaga gctgtagatt tatgttaaac     3420

tcgtacttac gaacaattgt aattagttct aaaaggcatg aactcagctc ctaatcgtca     3480

ctgtatagtc ctgaatttgt agaactagag ttaattccct cttggaactt tctttgttct     3540

tcagtagtta cttttttcct tacctaaaag ggttgtctgt caaacaattc ttgaataaac     3600

tttctgttat caattttaaa aaaaaaa                                         3627


<210>  25
<211>  1830
<212>  DNA
<213>  Homo sapiens

<400>  25
gtgaagcaca gggttataac gaccacgatc cacaaatcaa gccctccaaa atcacccaaa       60

tgagctcgta ctttgtaaac tccttctcgg ggcgttatcc aaatggcccg gactatcagt      120

tgctaaatta tggcagtggc agctctctga gcggctctta cagggatccc gctgccatgc      180

acaccggctc ttacggctac aattacaatg ggatggacct cagcgtcaac cgctcctcgg      240

cctcctccag ccactttggg gcggtgggcg agagctcgcg cgccttcccc gcgcccgccc      300

aggagccccg cttcaggcaa gcggcttcga gctgctccct gtcctcgccc gagtccctgc      360

cctgcaccaa cggcgacagc cacggcgcca agccctctgc ttcgtccccc tccgaccagg      420

cgacctcagc cagctccagc gccaatttca ccgaaataga cgaggccagc gcgtcctcgg      480

agcctgagga agcggcaagc cagctaagca gccccagcct agctcgggcg cagccagagc      540

ccatggccac ctccacagcc gcgcccgagg ggcagactcc gcaaatattc ccctggatga      600

ggaagcttca catcagccat gatatgaccg ggccggacgg gaaaagggcc cggaccgcgt      660

atacccgcta ccagaccctg gagctggaaa aggagttcca cttcaaccgc tacctgaccc      720

ggcgacggcg catcgagatc gcccacgcac tctgcctgtc cgagcgccag atcaagatct      780

ggttccagaa ccggcgcatg aagtggaaga aggacaacaa attgaaaagt atgagcctgg      840

ctacagctgg cagcgccttc cagccctgag cccgcccaga ggagcccagc ggcccaagag      900

cccgtgccac ccccagccct ggcccctcca atcctccccg ctctgccgcc gcccgctggg      960

gaccggttcc cacaagcctg cctcgccttg tgttacgata tttcgtttgg tcttaggtct     1020

tcctgtggct ccctctctcc tggactggtt atcttgttat tattgttaat aataattatt     1080

attattattt tccttccatg ctcccaactc ccttctgctt gtcccaaatc cgccagtgtt     1140

tctgaatgtt tgtgtctgtg gttgcagtct ttcccccagg aaaaaaaaaa aaagaaattc     1200

gcatgtttaa tgtgaactct cccctcccca tctgtgttct aacttattta taaaaagatg     1260

atcgctgtat tttgagtttc agctggaaac ttctgtaagg ggcagcagtt gaggtggggt     1320

agtgccgcag tggggtcaag ctgagctggc ttcggagatg gagtcccttt tcattctcct     1380

cctcctccct cctcactccc taggcccaag tctcctaggg gcttggtcct agggtgggaa     1440

ggggctaggg aggaccaaag ggatggtatt gagaagagag aaagaagata gtgagattta     1500

agttcctgct gcctgggtag gccccacaag gcctggtctg ggagtatacg gaaacaaaaa     1560

tgatcctcag tgcaaaatgt cttgtgtatt tctctgtgaa tccatgggtc tggctagagg     1620

gcccaaagct tgtaaatatg gggatagtct gggtcagacc catctctccc ttacccatct     1680

tgcttccaag accatttgta gtgagcgagt ggatgctgtg ctacgtgtga aatctgtctt     1740

tgcggggcct gtctcagtga ttcgcttttg gtatttgttt gtagctttcc tggaagtcaa     1800

ataaatgttt cccccactcc aaaaaaaaaa                                      1830


<210>  26
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  26
caccacacct aggtcggagc actgtcgtcc ttcagggctc cagcctcttg atatttttgt       60

acttcagtat cagctcgata gagcaaaaga gagagaggac gagagagggg gtcagagaag      120

gggaagcaac ggctctcacg ttgggacaat attatctgga agctgaagaa gaaactgaat      180

actccttcct tcctccccac ccattccttt aaatccggag ggggaaaaaa tcccaaggtc      240

tgcaaaggcg cggcgctcgg actataaaac acaacaaatc ataaacccgg cggagcagca      300

gcggccgcgc gcgcctcccc tcccaatgag ttcctatttc gtgaactcca ccttccccgt      360

cactctggcc agcgggcagg agtccttcct gggccagcta ccgctctatt cgtcgggcta      420

tgcggacccg ctgagacatt accccgcgcc ctacgggcca gggccgggcc aggacaaggg      480

ctttgccact tcctcctatt acccgccggc gggcggtggc tacggccgag cggcgccctg      540

cgactacggg ccggcgccgg ccttctaccg cgagaaagag tcggcctgcg cactctccgg      600

cgccgacgag cagcccccgt tccaccccga gccgcggaag tcggactgcg cgcaggacaa      660

gagcgtgttc ggcgagacag aagagcagaa gtgctccact ccggtctacc cgtggatgca      720

gcggatgaat tcgtgcaaca gttcctcctt tgggcccagc ggccggcgag gccgccagac      780

atacacacgt taccagacgc tggagctgga gaaggagttt cactacaatc gctacctgac      840

gcggcggcgg cgcatcgaga tcgcgcacgc cctgtgcctg acggagaggc agatcaagat      900

atggttccag aaccgacgca tgaagtggaa aaaggagagc aaactgctca gcgcgtctca      960

gctcagtgcc gaggaggagg aagaaaaaca ggccgagtga aggtgctgga aagggaggga     1020

ggacgcgagg ggaaaggcct gtggggagcc gagggcgtca gagagacccg ggaaggaagg     1080

ctctcgggtg ggggagccag gagacctgct ctccggcgca gacaggcggg gcccagcgct     1140

ctcctggacg cccccgcccg cacagctccc ggcgggtgct ctgaggcctc actactcgag     1200

cccacccagc atcccgcgcg cccttccttc ccgaggaact cgcctcagcc tgatcaggct     1260

tcctggtgag aactgaggag cggactcact tgatgtttcc tggaagcaga gcaaaatgct     1320

cttgtccctg tcgcgtctca ttttgtccat gtcccccgtg cacggttcaa tggtagattc     1380

gctgtcccct cagcgggggc cttgaagact ccctgatccc agacctgtcg tctctcccac     1440

cccctcccca aagccactgg aaggagcaca tactacctag aagtaagaag aggagcctca     1500

gaagaaaaca aagttctatt ttattaattt tctatgtgtt gtgtttgtag tcttgtctta     1560

gctctggacg tgaaatactt cgatgatgat gatgatgatg atgatgataa taataataat     1620

aataacaaca acaacaacaa taataaagat gtgaaaactc gacgctcggt cacctcaaaa     1680

aaaaaa                                                                1686


<210>  27
<211>  5680
<212>  DNA
<213>  Homo sapiens

<400>  27
aacgggctca ttcagcggtc gcgagctgcc cgcgaggggg agcggccgga cggagagcgc       60

gacccgtccc gggggtgggg ccgggcgcag cggcgagagg aggcgaaggt ggctgcggta      120

gcagcagcgc ggcagcctcg gacccagccc ggagcgcagg gcggccgctg caggtccccg      180

ctcccctccc cgtgcgtccg cccatggccg ccgccgggca gctgtgcttg ctctacctgt      240

cggcggggct cctgtcccgg ctcggcgcag ccttcaactt ggacactcgg gaggacaacg      300

tgatccggaa atatggagac cccgggagcc tcttcggctt ctcgctggcc atgcactggc      360

aactgcagcc cgaggacaag cggctgttgc tcgtgggggc cccgcgggca gaagcgcttc      420

cactgcagag agccaacaga acgggagggc tgtacagctg cgacatcacc gcccgggggc      480

catgcacgcg gatcgagttt gataacgatg ctgaccccac gtcagaaagc aaggaagatc      540

agtggatggg ggtcaccgtc cagagccaag gtccaggggg caaggtcgtg acatgtgctc      600

accgatatga aaaaaggcag catgttaata cgaagcagga atcccgagac atctttgggc      660

ggtgttatgt cctgagtcag aatctcagga ttgaagacga tatggatggg ggagattgga      720

gcttttgtga tgggcgattg agaggccatg agaaatttgg ctcttgccag caaggtgtag      780

cagctacttt tactaaagac tttcattaca ttgtatttgg agccccgggt acttataact      840

ggaaagggat tgttcgtgta gagcaaaaga ataacacttt ttttgacatg aacatctttg      900

aagatgggcc ttatgaagtt ggtggagaga ctgagcatga tgaaagtctc gttcctgttc      960

ctgctaacag ttacttaggt ttttctttgg actcagggaa aggtattgtt tctaaagatg     1020

agatcacttt tgtatctggt gctcccagag ccaatcacag tggagccgtg gttttgctga     1080

agagagacat gaagtctgca catctcctcc ctgagcacat attcgatgga gaaggtctgg     1140

cctcttcatt tggctatgat gtggcggtgg tggacctcaa caaggatggg tggcaagata     1200

tagttattgg agccccacag tattttgata gagatggaga agttggaggt gcagtgtatg     1260

tctacatgaa ccagcaaggc agatggaata atgtgaagcc aattcgtctt aatggaacca     1320

aagattctat gtttggcatt gcagtaaaaa atattggaga tattaatcaa gatggctacc     1380

cagatattgc agttggagct ccgtatgatg acttgggaaa ggtttttatc tatcatggat     1440

ctgcaaatgg aataaatacc aaaccaacac aggttctcaa gggtatatca ccttattttg     1500

gatattcaat tgctggaaac atggaccttg atcgaaattc ctaccctgat gttgctgttg     1560

gttccctctc agattcagta actattttca gatcccggcc tgtgattaat attcagaaaa     1620

ccatcacagt aactcctaac agaattgacc tccgccagaa aacagcgtgt ggggcgccta     1680

gtgggatatg cctccaggtt aaatcctgtt ttgaatatac tgctaacccc gctggttata     1740

atccttcaat atcaattgtg ggcacacttg aagctgaaaa agaaagaaga aaatctgggc     1800

tatcctcaag agttcagttt cgaaaccaag gttctgagcc caaatatact caagaactaa     1860

ctctgaagag gcagaaacag aaagtgtgca tggaggaaac cctgtggcta caggataata     1920

tcagagataa actgcgtccc attcccataa ctgcctcagt ggagatccaa gagccaagct     1980

ctcgtaggcg agtgaattca cttccagaag ttcttccaat tctgaattca gatgaaccca     2040

agacagctca tattgatgtt cacttcttaa aagagggatg tggagacgac aatgtatgta     2100

acagcaacct taaactagaa tataaatttt gcacccgaga aggaaatcaa gacaaatttt     2160

cttatttacc aattcaaaaa ggtgtaccag aactagttct aaaagatcag aaggatattg     2220

ctttagaaat aacagtgaca aacagccctt ccaacccaag gaatcccaca aaagatggcg     2280

atgacgccca tgaggctaaa ctgattgcaa cgtttccaga cactttaacc tattctgcat     2340

atagagaact gagggctttc cctgagaaac agttgagttg tgttgccaac cagaatggct     2400

cgcaagctga ctgtgagctc ggaaatcctt ttaaaagaaa ttcaaatgtc actttttatt     2460

tggttttaag tacaactgaa gtcacctttg acaccccaga tctggatatt aatctgaagt     2520

tagaaacaac aagcaatcaa gataatttgg ctccaattac agctaaagca aaagtggtta     2580

ttgaactgct tttatcggtc tcgggagttg ctaaaccttc ccaggtgtat tttggaggta     2640

cagttgttgg cgagcaagct atgaaatctg aagatgaagt gggaagttta atagagtatg     2700

aattcagggt aataaactta ggtaaacctc ttacaaacct cggcacagca accttgaaca     2760

ttcagtggcc aaaagaaatt agcaatggga aatggttgct ttatttggtg aaagtagaat     2820

ccaaaggatt ggaaaaggta acttgtgagc cacaaaagga gataaactcc ctgaacctaa     2880

cggagtctca caactcaaga aagaaacggg aaattactga aaaacagata gatgataaca     2940

gaaaattttc tttatttgct gaaagaaaat accagactct taactgtagc gtgaacgtga     3000

actgtgtgaa catcagatgc ccgctgcggg ggctggacag caaggcgtct cttattttgc     3060

gctcgaggtt atggaacagc acatttctag aggaatattc caaactgaac tacttggaca     3120

ttctcatgcg agccttcatt gatgtgactg ctgctgccga aaatatcagg ctgccaaatg     3180

caggcactca ggttcgagtg actgtgtttc cctcaaagac tgtagctcag tattcgggag     3240

taccttggtg gatcatccta gtggctattc tcgctgggat cttgatgctt gctttattag     3300

tgtttatact atggaagtgt ggattcttta aacgctctag gtacgatgac agtgttcccc     3360

gataccatgc tgtaaggatc cggaaagaag agcgagagat caaagatgaa aagtatattg     3420

ataaccttga aaaaaaacag tggatcacaa agtggaacga aaatgaaagc tactcatagc     3480

gggggcctaa aaaaaaaaag cttcacagta cccaaactgc tttttccaac tcagaaattc     3540

aatttggatt taaaagcctg ctcaatccct gaggactgat ttcagagtga ctacacacag     3600

tacgaaccta cagttttaac tgtggatatt gttacgtagc ctaaggctcc tgttttgcac     3660

agccaaattt aaaactgttg gaatggattt ttctttaact gccgtaattt aactttctgg     3720

gttgccttta tttttggcgt ggctgactta catcatgtgt tggggaaggg cctgcccagt     3780

tgcactcagg tgacatcctc cagatagtgt agctgaggag gcacctacac tcacctgcac     3840

taacagagtg gccgtcctaa cctcgggcct gctgcgcaga cgtccatcac gttagctgtc     3900

ccacatcaca agactatgcc attggggtag ttgtgtttca acggaaagtg ctgtcttaaa     3960

ctaaatgtgc aatagaaggt gatgttgcca tcctaccgtc ttttcctgtt tcctagctgt     4020

gtgaatacct gctcacgtca aatgcataca agtttcattc tccctttcac taaaacacac     4080

aggtgcaaca gacttgaatg ctagttatac ttatttgtat atggtattta ttttttcttt     4140

tctttacaaa ccattttgtt attgactaac aggccaaaga gtctccagtt tacccttcag     4200

gttggtttaa tcaatcagaa ttagagcatg ggaggtcatc actttgacct aaattattta     4260

ctgcaaaaag aaaatcttta taaatgtacc agagagagtt gttttaataa cttatctata     4320

aactataacc tctccttcat gacagcctcc accccacaac ccaaaaggtt taagaaatag     4380

aattataact gtaaagatgt ttatttcagg cattggatat tttttacttt agaagcctgc     4440

ataatgtttc tggatttcat actgtaacat tcaggaattc ttggagaaaa tgggtttatt     4500

cactgaactc tagtgcggtt tactcactgc tgcaaatact gtatattcag gacttgaaag     4560

aaatggtgaa tgcctatggt ggatccaaac tgatccagta taagactact gaatctgcta     4620

ccaaaacagt taatcagtga gtcgatgttc tattttttgt tttgtttcct cccctatctg     4680

tattcccaaa aattactttg gggctaattt aacaagaact ttaaattgtg ttttaattgt     4740

aaaaatggca gggggtggaa ttattactct atacattcaa cagagactga atagatatga     4800

aagctgattt tttttaatta ccatgcttca caatgttaag ttatatgggg agcaacagca     4860

aacaggtgct aatttgtttt ggatatagta taagcagtgt ctgtgttttg aaagaataga     4920

acacagtttg tagtgccact gttgttttgg gggggctttt ttcttttcgg aaatcttaaa     4980

ccttaagata ctaaggacgt tgttttggtt gtactttgga attcttagtc acaaaatata     5040

ttttgtttac aaaaatttct gtaaaacagg ttataacagt gtttaaagtc tcagtttctt     5100

gcttggggaa cttgtgtccc taatgtgttt agattgctag attgctaagg agctgatact     5160

ttgacagtgt ttttagacct gtgttactaa aaaaaagatg aatgtcctga aaagggtgtt     5220

gggagggtgg ttcaacaaag aaacaaagat gttatggtgt ttagatttat ggttgttaaa     5280

aatgtcatct caagtcaagt cactggtctg tttgcatttg atacattttt gtactaacta     5340

gcattgtaaa attatttcat gattagaaat tacctgtgga tatttgtata aaagtgtgaa     5400

ataaattttt tataaaagtg ttcattgttt cgtaacacag cattgtatat gtgaagcaaa     5460

ctctaaaatt ataaatgaca acctgaatta tctatttcat caaaccaaag ttcagtgttt     5520

ttatttttgg tgtctcatgt aatctcagat cagccaaaga tactagtgcc aaagcaatgg     5580

gattcggggt ttttttctgt tttcgctcta tgtaggtgat cctcaagtct ttcattttcc     5640

ttctttatga ttaaaagaaa cctacaggta tttaacaacc                           5680


<210>  28
<211>  5190
<212>  DNA
<213>  Homo sapiens

<400>  28
tctgggggct cggctttgcc gcgctcgctg cacttgggcg agagctggaa cgtggaccag       60

agctcggatc ccatcgcagc taccgcgatg agaggcgctc gcggcgcctg ggattttctc      120

tgcgttctgc tcctactgct tcgcgtccag acaggctctt ctcaaccatc tgtgagtcca      180

ggggaaccgt ctccaccatc catccatcca ggaaaatcag acttaatagt ccgcgtgggc      240

gacgagatta ggctgttatg cactgatccg ggctttgtca aatggacttt tgagatcctg      300

gatgaaacga atgagaataa gcagaatgaa tggatcacgg aaaaggcaga agccaccaac      360

accggcaaat acacgtgcac caacaaacac ggcttaagca attccattta tgtgtttgtt      420

agagatcctg ccaagctttt ccttgttgac cgctccttgt atgggaaaga agacaacgac      480

acgctggtcc gctgtcctct cacagaccca gaagtgacca attattccct caaggggtgc      540

caggggaagc ctcttcccaa ggacttgagg tttattcctg accccaaggc gggcatcatg      600

atcaaaagtg tgaaacgcgc ctaccatcgg ctctgtctgc attgttctgt ggaccaggag      660

ggcaagtcag tgctgtcgga aaaattcatc ctgaaagtga ggccagcctt caaagctgtg      720

cctgttgtgt ctgtgtccaa agcaagctat cttcttaggg aaggggaaga attcacagtg      780

acgtgcacaa taaaagatgt gtctagttct gtgtactcaa cgtggaaaag agaaaacagt      840

cagactaaac tacaggagaa atataatagc tggcatcacg gtgacttcaa ttatgaacgt      900

caggcaacgt tgactatcag ttcagcgaga gttaatgatt ctggagtgtt catgtgttat      960

gccaataata cttttggatc agcaaatgtc acaacaacct tggaagtagt agataaagga     1020

ttcattaata tcttccccat gataaacact acagtatttg taaacgatgg agaaaatgta     1080

gatttgattg ttgaatatga agcattcccc aaacctgaac accagcagtg gatctatatg     1140

aacagaacct tcactgataa atgggaagat tatcccaagt ctgagaatga aagtaatatc     1200

agatacgtaa gtgaacttca tctaacgaga ttaaaaggca ccgaaggagg cacttacaca     1260

ttcctagtgt ccaattctga cgtcaatgct gccatagcat ttaatgttta tgtgaataca     1320

aaaccagaaa tcctgactta cgacaggctc gtgaatggca tgctccaatg tgtggcagca     1380

ggattcccag agcccacaat agattggtat ttttgtccag gaactgagca gagatgctct     1440

gcttctgtac tgccagtgga tgtgcagaca ctaaactcat ctgggccacc gtttggaaag     1500

ctagtggttc agagttctat agattctagt gcattcaagc acaatggcac ggttgaatgt     1560

aaggcttaca acgatgtggg caagacttct gcctatttta actttgcatt taaaggtaac     1620

aacaaagagc aaatccatcc ccacaccctg ttcactcctt tgctgattgg tttcgtaatc     1680

gtagctggca tgatgtgcat tattgtgatg attctgacct acaaatattt acagaaaccc     1740

atgtatgaag tacagtggaa ggttgttgag gagataaatg gaaacaatta tgtttacata     1800

gacccaacac aacttcctta tgatcacaaa tgggagtttc ccagaaacag gctgagtttt     1860

gggaaaaccc tgggtgctgg agctttcggg aaggttgttg aggcaactgc ttatggctta     1920

attaagtcag atgcggccat gactgtcgct gtaaagatgc tcaagccgag tgcccatttg     1980

acagaacggg aagccctcat gtctgaactc aaagtcctga gttaccttgg taatcacatg     2040

aatattgtga atctacttgg agcctgcacc attggagggc ccaccctggt cattacagaa     2100

tattgttgct atggtgatct tttgaatttt ttgagaagaa aacgtgattc atttatttgt     2160

tcaaagcagg aagatcatgc agaagctgca ctttataaga atcttctgca ttcaaaggag     2220

tcttcctgca gcgatagtac taatgagtac atggacatga aacctggagt ttcttatgtt     2280

gtcccaacca aggccgacaa aaggagatct gtgagaatag gctcatacat agaaagagat     2340

gtgactcccg ccatcatgga ggatgacgag ttggccctag acttagaaga cttgctgagc     2400

ttttcttacc aggtggcaaa gggcatggct ttcctcgcct ccaagaattg tattcacaga     2460

gacttggcag ccagaaatat cctccttact catggtcgga tcacaaagat ttgtgatttt     2520

ggtctagcca gagacatcaa gaatgattct aattatgtgg ttaaaggaaa cgctcgacta     2580

cctgtgaagt ggatggcacc tgaaagcatt ttcaactgtg tatacacgtt tgaaagtgac     2640

gtctggtcct atgggatttt tctttgggag ctgttctctt taggaagcag cccctatcct     2700

ggaatgccgg tcgattctaa gttctacaag atgatcaagg aaggcttccg gatgctcagc     2760

cctgaacacg cacctgctga aatgtatgac ataatgaaga cttgctggga tgcagatccc     2820

ctaaaaagac caacattcaa gcaaattgtt cagctaattg agaagcagat ttcagagagc     2880

accaatcata tttactccaa cttagcaaac tgcagcccca accgacagaa gcccgtggta     2940

gaccattctg tgcggatcaa ttctgtcggc agcaccgctt cctcctccca gcctctgctt     3000

gtgcacgacg atgtctgagc agaatcagtg tttgggtcac ccctccagga atgatctctt     3060

cttttggctt ccatgatggt tattttcttt tctttcaact tgcatccaac tccaggatag     3120

tgggcacccc actgcaatcc tgtctttctg agcacacttt agtggccgat gatttttgtc     3180

atcagccacc atcctattgc aaaggttcca actgtatata ttcccaatag caacgtagct     3240

tctaccatga acagaaaaca ttctgatttg gaaaaagaga gggaggtatg gactgggggc     3300

cagagtcctt tccaaggctt ctccaattct gcccaaaaat atggttgata gtttacctga     3360

ataaatggta gtaatcacag ttggccttca gaaccatcca tagtagtatg atgatacaag     3420

attagaagct gaaaacctaa gtcctttatg tggaaaacag aacatcatta gaacaaagga     3480

cagagtatga acacctgggc ttaagaaatc tagtatttca tgctgggaat gagacatagg     3540

ccatgaaaaa aatgatcccc aagtgtgaac aaaagatgct cttctgtgga ccactgcatg     3600

agcttttata ctaccgacct ggtttttaaa tagagtttgc tattagagca ttgaattgga     3660

gagaaggcct ccctagccag cacttgtata tacgcatcta taaattgtcc gtgttcatac     3720

atttgagggg aaaacaccat aaggtttcgt ttctgtatac aaccctggca ttatgtccac     3780

tgtgtataga agtagattaa gagccatata agtttgaagg aaacagttaa taccattttt     3840

taaggaaaca atataaccac aaagcacagt ttgaacaaaa tctcctcttt tagctgatga     3900

acttattctg tagattctgt ggaacaagcc tatcagcttc agaatggcat tgtactcaat     3960

ggatttgatg ctgtttgaca aagttactga ttcactgcat ggctcccaca ggagtgggaa     4020

aacactgcca tcttagtttg gattcttatg tagcaggaaa taaagtatag gtttagcctc     4080

cttcgcaggc atgtcctgga caccgggcca gtatctatat atgtgtatgt acgtttgtat     4140

gtgtgtagac aaatatttgg aggggtattt ttgccctgag tccaagaggg tcctttagta     4200

cctgaaaagt aacttggctt tcattattag tactgctctt gtttcttttc acatagctgt     4260

ctagagtagc ttaccagaag cttccatagt ggtgcagagg aagtggaagg catcagtccc     4320

tatgtatttg cagttcacct gcacttaagg cactctgtta tttagactca tcttactgta     4380

cctgttcctt agaccttcca taatgctact gtctcactga aacatttaaa ttttaccctt     4440

tagactgtag cctggatatt attcttgtag tttacctctt taaaaacaaa acaaaacaaa     4500

acaaaaaact ccccttcctc actgcccaat ataaaaggca aatgtgtaca tggcagagtt     4560

tgtgtgttgt cttgaaagat tcaggtatgt tgcctttatg gtttccccct tctacatttc     4620

ttagactaca tttagagaac tgtggccgtt atctggaagt aaccatttgc actggagttc     4680

tatgctctcg cacctttcca aagttaacag attttggggt tgtgttgtca cccaagagat     4740

tgttgtttgc catactttgt ctgaaaaatt cctttgtgtt tctattgact tcaatgatag     4800

taagaaaagt ggttgttagt tatagatgtc taggtacttc aggggcactt cattgagagt     4860

tttgtcttgg atattcttga aagtttatat ttttataatt ttttcttaca tcagatgttt     4920

ctttgcagtg gcttaatgtt tgaaattatt ttgtggcttt ttttgtaaat attgaaatgt     4980

agcaataatg tcttttgaat attcccaagc ccatgagtcc ttgaaaatat tttttatata     5040

tacagtaact ttatgtgtaa atacataagc ggcgtaagtt taaaggatgt tggtgttcca     5100

cgtgttttat tcctgtatgt tgtccaattg ttgacagttc tgaagaattc taataaaatg     5160

tacatatata aatcaaaaaa aaaaaaaaaa                                      5190


<210>  29
<211>  3198
<212>  DNA
<213>  Homo sapiens

<400>  29
atttgaggtg ttctgaccag aagaagacag agcggatgat cattcattca ccacgttgac       60

aacctcgcct gtgattgaca gctggagtgg cagaaagcca tgagatttgg tagttgggtc      120

tgaggggcgc tctttttttt ccttttcttt ctttctttct tttttttttt ttaaactgat      180

ttttggggga gagaagatct gctttttttt gcccccgctg ctgtcttgga aacggagcgc      240

ttttatgctc agtgactcgg gcgctttgct tcaggtcccg tagaccgaag atctgggacc      300

agtagctcac gttgctggag acgttaaggg atttttcgtc gtgctttttt tttttttttt      360

ttttttttcc gggggagttt gaatatttgt ttcttttcac actggcctta aagaggatat      420

attagaagtt gaagtaggaa gggagccaga gaggccgatg gcgcaaaggt acgacgatct      480

accccattac gggggcatgg atggagtagg catcccctcc acgatgtatg gggacccgca      540

tgcagccagg tccatgcagc cggtccacca cctgaaccac gggcctcctc tgcactcgca      600

tcagtacccg cacacagctc ataccaacgc catggccccc agcatgggct cctctgtcaa      660

tgacgcttta aagagagata aagatgccat ttatggacac cccctcttcc ctctcttagc      720

actgattttt gagaaatgtg aattagctac ttgtaccccc cgcgagccgg gggtggcggg      780

cggggacgtc tgctcgtcag agtcattcaa tgaagatata gccgtgttcg ccaaacagat      840

tcgcgcagaa aaacctctat tttcttctaa tccagaactg gataacttga tgattcaagc      900

catacaagta ttaaggtttc atctattgga attagagaag gtacacgaat tatgtgacaa      960

tttctgccac cggtatatta gctgtttgaa agggaaaatg cctatcgatt tggtgataga     1020

cgatagagaa ggaggatcaa aatcagacag tgaagatata acaagatcag caaatctaac     1080

tgaccagccc tcttggaaca gagatcatga tgacacggca tctactcgtt caggaggaac     1140

cccaggccct tccagcggtg gccacacgtc acacagtggg gacaacagca gtgagcaagg     1200

tgatggcttg gacaacagtg tagcttcccc cagcacaggt gacgatgatg accctgataa     1260

ggacaaaaag cgtcacaaaa agcgtggcat ctttcccaaa gtagccacaa atatcatgag     1320

ggcgtggctg ttccagcatc taacacaccc ttacccttct gaagaacaga aaaagcagtt     1380

ggcacaagac acgggactca ccatccttca agtgaacaat tggtttatta atgcccggag     1440

aagaatagtg cagcccatga tagaccagtc caaccgagca gtaagtcaag gaacacctta     1500

taatcctgat ggacagccca tgggaggttt cgtaatggac ggtcagcaac atatgggaat     1560

tagagcacca ggacctatga gtggaatggg catgaatatg ggcatggagg ggcagtggca     1620

ctacatgtaa ccttcatcta gttaaccaat cgcaaagcaa gggggaaggc tgcaaagtat     1680

gccaggggag tatgtagccc ggggtggtcc aatgggtgtg agtatgggac agccaagtta     1740

tacccaaccc cagatgcccc cccatcctgc tcagctgcgt catgggcccc ccatgcatac     1800

gtacattcct ggacaccctc accacccaac agtgatgatg catggaggac cgccccaccc     1860

tggaatgcca atgtcagcat caagccccac agttcttaat acaggagacc caacaatgag     1920

tggacaagtc atggacattc atgctcagta gcttaaggga atatgcattg tctgcaatgg     1980

tgactgattt caaatcatgt tttttctgca atgactgtgg agttccattc ttggcatcta     2040

ctctggacca aggagcatcc ctaattcttc atagggacct ttaaaaagca ggaaatacca     2100

actgaagtca atttggggga catgctaaat aactatataa gacattaaga gaacaaagag     2160

tgaaatattg taaatgctat tatactgtta tccatattac gttgtttctt atagattttt     2220

taaaaaaaat gtgaaatttt tccacactat gtgtgttgtt tccatagctc ttcacttcct     2280

ccagaagcct ccttacatta aaaagcctta cagttatcct gcaagggaca ggaaggtctg     2340

atttgcagga tttttagagc attaaaataa ctatcaggca gaagaatctt tcttctcgcc     2400

taggatttca gccatgcgcg cgctctctct ctttctctct cttttcctct ctctccctct     2460

ttctagcctg gggcttgaat ttgcatgtct aattcattta ctcaccatat ttgaattggc     2520

ctgaacagat gtaaatcggg aaggatggga aaaactgcag tcatcaacaa tgattaatca     2580

gctgttgcag gcagtgtctt aaggagactg gtaggaggag gcatggaaac caaaaggccg     2640

tgtgtttaga agcctaattg tcacatcaag catcattgtc cccatgcaac aaccaccacc     2700

ttatacatca cttcctgttt taagcagctc taaaacatag actgaagatt tatttttaat     2760

atgttgactt tatttctgag caaagcatcg gtcatgtgtg tattttttca tagtcccacc     2820

ttggagcatt tatgtagaca ttgtaaataa attttgtgca aaaaggactg gaaaaatgaa     2880

ctgtattatt gcaatttttt tttgtaaaag tagcagtttg gtatgagttg gcatgcatac     2940

aagatttact aagtgggata agctaattat actttttgtt gtggataaac aaatgcttgt     3000

tgatagcctt tttctatcaa gaaaccaagg agctaattat taataacaat cattgcacac     3060

tgagtcttag cgtttctgat ggaaacagtt tggattgtat aataacgcca agcccagttg     3120

tagtcgtttg agtgcagtaa tgaaatctga atctaaaata aaaacaagat tatttttgtc     3180

aaaaaaaaaa aaaaaaaa                                                   3198


<210>  30
<211>  3046
<212>  DNA
<213>  Homo sapiens

<400>  30
gctttcctct cctttctccc tcccccttgt ctgcgccaca gcccccttct ctccccgccc       60

cccgggtgtg tcagattttt cagttaataa tatcccccga gcttcaaagc gcaggctgtg      120

acagtcatct gtctggacgc gctgggtgga tgcggggggc tcctgggaac tgtgttggag      180

ccgagcaagc gctagccagg cgcaagcgcg cacagactgt agccatccga ggacaccccc      240

gcccccccgg cccacccgga gacacccgcg cagaatcgcc tccggatccc ctgcagtcgg      300

cgggaggtaa ggagcagggc ttgcaaaccg cccggcgccc agggaagcga cgagcgccgg      360

ggcaaggcaa gccctggacg ggattgcgac gtgcgcaccg ggcgccctaa tatgcccggg      420

ggactgtttc tgcttccgaa acaaaaccat ctctgggttt tcccagaaaa gccagttcca      480

gccccgaagg catcctggct agaggagacc cgccctaatc cttttgcagc ccttaccggg      540

gggagtaatg gcttctgcga aaagaaattc cctcggctct agaagatctg tctgtgtttg      600

agctgtcgga gagccgtgtt ggaggtcggc gccggccccc gccttccgcg ccccccacgg      660

gaaggaagca cccccggtat taaaacgaac ggggcggaaa gaagccctca gtcgccggcc      720

gggaggcgag ccgatgccga gctgctccac gtccaccatg ccgggcatga tctgcaagaa      780

cccagacctc gagtttgact cgctacagcc ctgcttctac ccggacgaag atgacttcta      840

cttcggcggc cccgactcga cccccccggg ggaggacatc tggaagaagt ttgagctgct      900

gcccacgccc ccgctgtcgc ccagccgtgg cttcgcggag cacagctccg agcccccgag      960

ctgggtcacg gagatgctgc ttgagaacga gctgtggggc agcccggccg aggaggacgc     1020

gttcggcctg gggggactgg gtggcctcac ccccaacccg gtcatcctcc aggactgcat     1080

gtggagcggc ttctccgccc gcgagaagct ggagcgcgcc gtgagcgaga agctgcagca     1140

cggccgcggg ccgccaaccg ccggttccac cgcccagtcc ccgggagccg gcgccgccag     1200

ccctgcgggt cgcgggcacg gcggggctgc gggagccggc cgcgccgggg ccgccctgcc     1260

cgccgagctc gcccacccgg ccgccgagtg cgtggatccc gccgtggtct tcccctttcc     1320

cgtgaacaag cgcgagccag cgcccgtgcc cgcagccccg gccagtgccc cggcggcggg     1380

ccctgcggtc gcctcggggg cgggtattgc cgccccagcc ggggccccgg gggtcgcccc     1440

tccgcgccca ggcggccgcc agaccagcgg cggcgaccac aaggccctca gtacctccgg     1500

agaggacacc ctgagcgatt cagatgatga agatgatgaa gaggaagatg aagaggaaga     1560

aatcgacgtg gtcactgtgg agaagcggcg ttcctcctcc aacaccaagg ctgtcaccac     1620

attcaccatc actgtgcgtc ccaagaacgc agccctgggt cccgggaggg ctcagtccag     1680

cgagctgatc ctcaaacgat gccttcccat ccaccagcag cacaactatg ccgccccctc     1740

tccctacgtg gagagtgagg atgcaccccc acagaagaag ataaagagcg aggcgtcccc     1800

acgtccgctc aagagtgtca tccccccaaa ggctaagagc ttgagccccc gaaactctga     1860

ctcggaggac agtgagcgtc gcagaaacca caacatcctg gagcgccagc gccgcaacga     1920

ccttcggtcc agctttctca cgctcaggga ccacgtgccg gagttggtaa agaatgagaa     1980

ggccgccaag gtggtcattt tgaaaaaggc cactgagtat gtccactccc tccaggccga     2040

ggagcaccag cttttgctgg aaaaggaaaa attgcaggca agacagcagc agttgctaaa     2100

gaaaattgaa cacgctcgga cttgctagac gcttctcaaa actggacagt cactgccact     2160

ttgcacattt tgattttttt tttaaacaaa cattgtgttg acattaagaa tgttggttta     2220

ctttcaaatc ggtcccctgt cgagttcggc tctgggtggg cagtaggacc accagtgtgg     2280

ggttctgctg ggaccttgga gagcctgcat cccaggatgc tgggtggccc tgcagcctcc     2340

tccacctcac ctccatgaca gcgctaaacg ttggtgacgg ttgggagcct ctggggctgt     2400

tgaagtcacc ttgtgtgttc caagtttcca aacaacagaa agtcattcct tctttttaaa     2460

atggtgctta agttccagca gatgccacat aaggggtttg ccatttgata cccctgggga     2520

acatttctgt aaataccatt gacacatccg ccttttgtat acatcctggg taatgagagg     2580

tggcttttgc ggccagtatt agactggaag ttcataccta agtactgtaa taatacctca     2640

atgtttgagg agcatgtttt gtatacaaat atattgttaa tctctgttat gtactgtact     2700

aattcttaca ctgcctgtat actttagtat gacgctgata cataactaaa tttgatactt     2760

atattttcgt atgaaaatga gttgtgaaag ttttgagtag atattacttt atcacttttt     2820

gaactaagaa acttttgtaa agaaatttac tatatatata tgcctttttc ctagcctgtt     2880

tcttcctgtt aatgtatttg ttcatgtttg gtgcatagaa ctgggtaaat gcaaagttct     2940

gtgtttaatt tcttcaaaat gtatatattt agtgctgcat cttatagcac tttgaaatac     3000

ctcatgttta tgaaaataaa tagcttaaaa ttaaatgaaa aaaaaa                    3046


<210>  31
<211>  2247
<212>  DNA
<213>  Homo sapiens

<400>  31
aattgtgcag ggggcggtgt ttgtgcgtgg agctttccct cccggctccg ggccgtcgcg       60

gctctcggga gaggcgccgg gacattttaa tcgctgcctc cgccgcgcag ccctgcgcag      120

ctgcccggcc gcgccaaccc cttccccgcc gcagcgcgcc ccgagtgttg gcagcttgcc      180

agccgccacc ccccgccttc cctcctgccc accccaaggt agagggctcc tctcgggagt      240

gtgcggggaa ggggaggccg aggtccgggc cacgcccggg tagccgcaac ccgcagtgct      300

cagtcggcaa caggtagccc agcaggctgc ggctctcagg aagacaaaaa gcgcctctgc      360

gagcaaataa cgaaggaggc ccaacttcat tcaataagga gcctgacgga tttatcccag      420

acggtagaac aaaaggaaga atattgatgg attttaaacc agagttttta aagagcttga      480

gaatacgggg aaattaattt gttctcctac acacatagat agggtaaggt tgtttctgat      540

gcagctgaga aaaatgcaga ccgtcaaaaa ggagcaggcg tctcttgatg ccagtagcaa      600

tgtggacaag atgatggtcc ttaattctgc tttaacggaa gtgtcagaag actccacaac      660

aggtgaggag ctgcttctca gtgaaggaag tgtggggaag aacaaatctt ctgcatgtcg      720

gaggaaacgg gaattcattc ctgatgaaaa gaaagatgct atgtattggg aaaaaaggcg      780

gaaaaataat gaagctgcca aaagatctcg tgagaagcgt cgactgaatg acctggtttt      840

agagaacaaa ctaattgcac tgggagaaga aaacgccact ttaaaagctg agctgctttc      900

actaaaatta aagtttggtt taattagctc cacagcatat gctcaagaga ttcagaaact      960

cagtaattct acagctgtgt actttcaaga ttaccagact tccaaatcca atgtgagttc     1020

atttgtggac gagcacgaac cctcgatggt gtcaagtagt tgtatttctg tcattaaaca     1080

ctctccacaa agctcgctgt ccgatgtttc agaagtgtcc tcagtagaac acacgcagga     1140

gagctctgtg cagggaagct gcagaagtcc tgaaaacaag ttccagatta tcaagcaaga     1200

gccgatggaa ttagagagct acacaaggga gccaagagat gaccgaggct cttacacagc     1260

gtccatctat caaaactata tggggaattc tttctctggg tactcacact ctcccccact     1320

actgcaagtc aaccgatcct ccagcaactc cccgagaacg tcggaaactg atgatggtgt     1380

ggtaggaaag tcatctgatg gagaagacga gcaacaggtc cccaagggcc ccatccattc     1440

tccagttgaa ctcaagcatg tgcatgcaac tgtggttaaa gttccagaag tgaattcctc     1500

tgccttgcca cacaagctcc ggatcaaagc caaagccatg cagatcaaag tagaagcctt     1560

tgataatgaa tttgaggcca cgcaaaaact ttcctcacct attgacatga catctaaaag     1620

acatttcgaa ctcgaaaagc atagtgcccc aagtatggta cattcttctc ttactccttt     1680

ctcagtgcaa gtgactaaca ttcaagattg gtctctcaaa tcggagcact ggcatcaaaa     1740

agaactgagt ggcaaaactc agaatagttt caaaactgga gttgttgaaa tgaaagacag     1800

tggctacaaa gtttctgacc cagagaactt gtatttgaag caggggatag caaacttatc     1860

tgcagaggtt gtctcactca agagacttat agccacacaa ccaatctctg cttcagactc     1920

tgggtaaatt actactgagt aagagctggg catttagaaa gatgtcattt gcaatagagc     1980

agtccatttt gtattatgct gaattttcac tggacctgtg atgtcatttc actgtgatgt     2040

gcacatgttg tctgtttggt gtctttttgt gcacagatta tgatgaagat tagattgtgt     2100

tatcactctg cctgtgtata gtcagatagt ccatgcgaag gctgtatata ttgaacatta     2160

tttttgttgt tctattataa agtgtgtaag ttaccagttt caataaagga ttggtgacaa     2220

acacagaaaa aaaaaaaaaa aaaaaaa                                         2247


<210>  32
<211>  13443
<212>  DNA
<213>  Homo sapiens

<400>  32
actcgcacgg ccccttcctc cctcctctcc cggccgctcg catttcctgc cgctctggct       60

ctcccggccc ctcaaagttc tttccaactt tttctcggcg gagtgagcgc agcgggcgca      120

gactcggggg caggttgctg tgcttctccg ggctcagccg cctgctctcc tggctcaggt      180

cctcggggag ccctagacag acatcaagtg gccactggcg ctccttcccc tcccagctga      240

gccatcctcc ccggcctcct cgggcgggac agccccgtgc ttaggttttt ctccttttct      300

cccccggtgc gcctctgctc ggactctcgc gccgggatcg cggcggaaac ctccctcccc      360

tttcgcctcc tgcggctcct tcccttcgcc cctcctccgc cagtcactgg aatcaattcc      420

gtggggaatc ggctccgccg ccgcgaagga cagcctttcc gcgcgggact ccggggcgcc      480

acgggggcca tgtaagcagc tatcttccag agggccacac tgggcatgga cacccttttc      540

cctgcctgga ggagcacagg tgatagtgta attttccagt cacgaaactg ctaaggccat      600

ctcaggggcg tgtgcgccag gataggcggg cggcgtccga ggaccacata gccatgcctt      660

ttggtctgaa gctccgccgg acacggcgct acaacgtcct gagcaagaac tgctttgtca      720

cacggattcg cctgctggac agcaatgtta tcgagtgcac gctgtcggtg gaaagcacag      780

ggcaagaatg cctggaggct gtggcccaga ggctggagct gcgagagacg cactactttg      840

gcctttggtt tctcagcaag agccagcaag cacgatgggt ggagctggag aaacctctga      900

agaaacatct ggacaaattc gctaatgagc ctttgctttt ctttggagtc atgttctatg      960

tgccaaatgt gtcatggctt cagcaagagg ccacaagata tcagtattac ctgcaagtca     1020

aaaaagatgt gcttgaaggg cgattacgat gtacattgga ccaggtgatt cggctagccg     1080

gcctagctgt gcaagctgat tttggagact ataatcagtt tgattctcaa gatttcctca     1140

gagagtatgt gctatttcct atggatttgg ccctggaaga ggctgttctg gaggagctga     1200

cccagaaggt agcccaagaa cacaaagccc acagtggaat cctgccagca gaagctgaac     1260

tgatgtacat caatgaagtt gaacgtttgg atggatttgg acaggaaatc ttccctgtaa     1320

aggacaatca tggaaactgt gtacaccttg gcattttctt tatggggatt ttcgtgagga     1380

acagaattgg aagacaagcg gtaatataca ggtggaatga catggggaat atcactcata     1440

acaagtcgac cattctagtg gagctcatca acaaagaaga gactgccctc tttcacacgg     1500

atgatatcga aaatgccaag tatatttctc ggttgtttgc cacacgacac aagttttaca     1560

aacaaaacaa aatctgcact gaacagtcaa attctccacc ccccatcaga cgccagccca     1620

cctggagccg atcctctctg cccaggcagc agccgtacat cctgcctccc gttcacgtcc     1680

agtgtggtga gcactactcg gaaacgcaca cctcgcaaga cagcattttt catgggaatg     1740

aagaagcctt gtattgcaac tctcacaaca gcctggactt aaattattta aatggcactg     1800

tcaccaatgg cagcgtgtgt agcgttcaca gcgtcaactc cctcaactgc tcgcaaagtt     1860

tcatccaggc ctcccctgta tcctccaacc tcagtatccc tgggagtgac atcatgcggg     1920

ccgactacat cccgagccac cggcacagcg cgatcatcgt gccctcgtac aggccaaccc     1980

ccgattatga gacagtcatg cgccagatga agagggggat cctgcataca gacagccaga     2040

gccagtctct gagaaacctc aacattatca acacccatgc ctacaaccag ccagaggatc     2100

tggtgtacag ccaaccggag atgcgggaga ggcaccccta cactgtccct tatgggccac     2160

agggggtcta cagcaacaaa cttgtcagtc catctgacca gaggaaccca aagaataatg     2220

tggtaccaag caagccgggg gcaagcgcca tctcgcacac ggtgagcacc ccagagctgg     2280

ccaacatgca gctgcagggc agccataact acagcacggc ccacatgctt aagaactatc     2340

tcttcaggcc accgcccccc tacccacggc cacgacctgc caccagcacc ccagacctgg     2400

ccagccaccg ccacaagtac gtcagcggca gcagcccgga cctggtgacc cggaaggtgc     2460

agctctcggt gaagaccttc caagaggaca gctctccggt ggttcatcag tctctccagg     2520

aggtgagcga gcccctcacg gccaccaagc accacggcac tgtgaacaag cgccacagcc     2580

tggaggtgat gaacagcatg gtgcggggca tggaggccat gacgctcaag tcgctccacc     2640

tccccatggc tcgccgcaac acgctccggg agcagggacc gcccgaggag gggtcaggca     2700

gccacgaggt cccccagctc cctcagtatc accacaagaa gaccttctct gatgccacta     2760

tgctaatcca cagcagcgag agtgaggagg aggaggagga ggctccagaa tcggtgcccc     2820

agatccccat gctccgggag aagatggagt acagtgccca gctgcaggcg gccctggccc     2880

gcatccccaa caagcccccg cctgagtacc ccggtccaag gaagagtgtg agcaatgggg     2940

ctctgaggca ggaccaagcc agccttcctc ccgccatggc cagagccagg gtgctgaggc     3000

atgggccagc caaggccatc agcatgtctc ggactgaccc gccggctgtc aacggggcct     3060

ctctcggccc atccatctcg gaacccgacc tgactagtgt gaaggagcgg gtcaaaaaag     3120

agcctgtgaa ggagagacct gtgtctgaaa tgttttccct ggaagacagc attatagaga     3180

gagagatgat gatcaggaat ctagagaagc agaagatggc aggcctggag gcacagaaga     3240

ggccgctgat gttggcagca ttgaatgggc tctcggtggc tcgagtctca gggcgggaag     3300

agaatcgagt tgatgccacc cgggttccca tggacgagag gttcagaacc ctgaagaaga     3360

aactagaaga gggaatggtg ttcacagaat atgagcaaat tccaaagaaa aaggcgaatg     3420

gcattttcag cacagcagct ctgccagaaa acgccgagcg cagccgaatc cgtgaagttg     3480

tcccctatga ggagaatcga gtagagctga taccaaccaa agaaaataac acaggataca     3540

ttaatgcctc ccacatcaag gtggtggttg gcggggcaga atggcactac atagccaccc     3600

aggggcccct gccacacacg tgccacgact tctggcagat ggtgtgggag cagggagtga     3660

atgtgattgc catggtcact gcagaggagg agggtggacg aaccaaaagc caccgatact     3720

ggcccaaact aggttcaaag cacagctcag ccacctatgg caagttcaag gtcaccacga     3780

agtttcgaac ggattctgtt tgctatgcaa ccacgggctt gaaggtcaag caccttttgt     3840

ctgggcaaga aaggacggtg tggcatttac aatatactga ctggccagat cacggctgtc     3900

cagaagatgt ccaaggattt ttatcctact tggaggagat ccagtcggtc cgtcgccata     3960

ccaacagcat gctggaaggc accaagaacc ggcacccgcc catcgtggtc cactgtagtg     4020

ctggggtggg aaggaccggc gtgctcattc tttctgagct gatgatctac tgcttggaac     4080

ataacgaaaa ggtggaagtg cccatgatgc tgaggctcct cagggagcag aggatgttca     4140

tgatccagac tatcgctcag tacaagtttg tctaccaagt cctcatccag ttcctccaaa     4200

actccagact catttaatca ccccaatcca gctcctggag gagggaccca gctccatcgc     4260

gctggaggag agtcacctcc agacaacatc tgctcccccc acaggggtgc aggtggctgg     4320

cagcaaacag gctctctgaa gacagtagcc aagattattc acacatacca tgtattattt     4380

tatatgagat aatttatttt tttccccttt ggaataactt ttgtgaatta ttataatgca     4440

gtttccctag taatatagta cttttcattt gaaccacatc ttgactgatc tgtattgtaa     4500

tatatgtcag caggtaaggt tgcctgctgg atcattttga ggacagaggc atgagggagc     4560

acatctcttg tgaagttgca gccagatttg taaccaaccc tgaaattcat cagcttaatt     4620

catttatcag cttgattcat tcatcattca ttgcttatat ccaaagcaaa gacggtaaga     4680

aaatgaattc atcctgaaat ataaagaaaa gggtctgaag gaacaaacac gattctctta     4740

tattttgggg ctcatgagcc ttgatagaca gtttcctctc gtcttcattt ccacccctca     4800

tcctcagtag tctcctctcc cccacgcccc accccaactt cccccccaag cttgagttaa     4860

agacagaata gctaaagaca gtgctgcctt tacaatgcag taattgccat ctttggggcc     4920

gaaagacaag ctctgtgttg tgcttttctt gaccacccct tatcctgggc tctggagctt     4980

gtgtttccct gctggcgact gtaccttggg tatttgttgc tacctctcct gtttgctcag     5040

taggaccctg tctggtggca ttgaggctct ggaccagacc atctgtgcag ttaaggctct     5100

accctgattg agagaggata gcagacctag aaagagaaag gagttgggca gggcctttga     5160

ggattgtgtt tttcaggcag ggccttgatg atcattgttt tttatttaaa taagatgtgt     5220

gtgctggaca gagacctaaa agttgaggtc actaagtcat tggaaaggcc atcaaggaaa     5280

cagatgggga agctgattta tgggagctgt aaggcattta gctacataac aggggtcctg     5340

gccaggaaac acatcaaatg tgacccccgc tgtgctgata tcatcttcag gctttggtct     5400

gcaagatcag aattaatccc actcgggacc ccatagtcca aacttggggc cacttgatga     5460

acgatggtag aattgtcatt ggcagagccc tgtgcttctt tccttttctt cataaaatcc     5520

actcgctggt cagttatctt cactttgaag cccagttctt agtttcttcc tatggcttca     5580

ttggtcagtg tccttctgaa tttccaagga tggtacacaa taaatcatgt tttgtacttt     5640

tttcctctta ctgcattttg ggggatttat cattctatgt ctaccttttc ttgagtacag     5700

ctttgatatg cacctgttgt tacgtggtga tgggaagtca caggcgtgct ctttctagtt     5760

aatttgatgc cacatcttcc ttgtcttttc agcttgggaa aaaggcggca gtggaggaag     5820

gcatggaatg cccacagtgg tcagttcaaa gaacaaacgt gcaattaaaa aactgtagtc     5880

agccaggcac ggtggttcac acctgtaatc ccagcacttt gaaaggccaa ggcgggcaga     5940

ttgcttgagc taaggagttc gagaccagcc tgagcaacat gatgaaaccc cgtctctaca     6000

aaaagtacaa aaattagcca ggcgtggtgg tatgccctgg tagtcccagc tgctcgggag     6060

gctgaggcag gaggatcacc tgattctaag aattcgagac tgcagtgagc cgtgatcttg     6120

ccactgtagt ccaggctggg ctacggagag accctgcctc caaaaaaaaa aaaaaaaaag     6180

gaaaaaaggt tgtcaagaaa aactagatgt taggagaaag gaaaatttaa ttgcagtttt     6240

ttttcttaga attgactgct gtgagagttc catatgcctt tcttcattgc tgcttttgtc     6300

ccccgtgagc taaaaagatg gagtgacatc aaatcaacca gaaaaagtat gcctttgtga     6360

catcccatca ccacatgcca acaggtatat attccccatt aagttcttcg gaataggaat     6420

cctctgtttc aacctggcca ggtgttgtgg tggctgtact ctagttagac tcggaatatc     6480

tggggatgga gggcttcccc tgtgtcttct acttcaaggt ctgaaggctc agtgaaggag     6540

tataatctgc tgatctttgt agattctgga gttttgttgt atgtcctgga aagaaaccca     6600

ttagtattac atgtattttc agtgaacaga gcttataacc cttattataa gaagctcatc     6660

aataagcaaa aagatacttg tttcctttcc ttggaggttt ttccatcctt gggatattct     6720

gctgttaggg atgttttagc aagtggtctc agttactggt ttattgcgtg atgaacaaca     6780

tcagtattta tcttttatct ctaagcccca aggtgggcac tgttagaata tgtctcatgt     6840

ggacagcata tagatctggt gcgtctttga ggtcgtcaga gctcatgggc ttccctgaaa     6900

ttcatccact gtccctgccg tatgctacgg gaatattcat tagtgtacaa aatgcaggga     6960

ggaagtaggt ttaatattca actttctagc caaagtttat attgaaaccc aaaagaaaac     7020

atttaagagt tgttccacat atttcacttt taaaaacaaa tgcctttggt tctttagcac     7080

attttgcatt ccttttcaca tctccagtaa atgccaacat atctcctgtt aaattagcag     7140

cagccattta aagtcctttc ggtggcatct gcataataat tgcccagaga tgctttatat     7200

ctgggaagca agccaaggaa taaaccttga agcaaagtgt attaaattag ttatctagtt     7260

agagcttttg gaatgatttc ctgatgatgt atcaagtctg aagctggagc tgtcagtgtc     7320

tattgctgca gtttggattt gaagggagaa aatgtaaaat ggaggaaaaa aaagttacca     7380

tctcacaaca aagccatcaa acattttcca gccgctgttt tcgaggtttt ccagttgaac     7440

tgtttggttt ctttcatcca cactcatttg gatacattga cccgaggtat tcatccttgt     7500

ttactgtggt ccctgaatca tgggggctga atttgatgtc ttcatccttg agatgagcct     7560

gctggcttag ctgaggaatg tcctgctgag gtttcttagg tttccttggg ttctaaggat     7620

atactggata taccatcttt tagcaagagt atctggtagc atttacagat agcatagaca     7680

ttggtatgca cttctttccc cagataggaa gtaaaggagg atttagttgc atgaaaaaag     7740

gatgttaaac attgattaca taggagtaaa gatgaatgag ctgcaatatt cagtcggagc     7800

taaacaataa gatcagggaa ggtaaaaata cctatgtgga atattttgaa tcgtaagctt     7860

ttgaggagct taaattgaga gaattttact tttaattttg tagattgaga agaggaaccg     7920

ctttttaaaa ttatagctaa actgtcattg ttttcctaag agtcacttgg ccatctctgg     7980

ccccctcttt catcagcctg aagagagggt ctttgtagac tgctgagggt gggccttgta     8040

ggacttgacc atggcttaca cctacttaac ctttatcctg ctttctttca gcttgtgctt     8100

ttcagttata aactccagtg ggtacagcag gctggccttt tcatccagct gattattttt     8160

ccagcttaat atagattgac ccatatgaaa tttccaataa tggaccatat tttctgcaaa     8220

tagacagtac tcgcatggat cacctatatc ttccccctga tacactgtgg gtcccaacac     8280

cagatgtcat ttctccagag cagtgctaat gaacacaaaa ggtataccct gggtggccca     8340

gctcttttca cgaacgtgct gccctgctca tagtgatcct tgcatcactt ggtgaatggg     8400

ccatctcctg ggacatggaa gttgcagagg tagatagtgc actgcagctt ctcttaagcc     8460

ggattggcca tcaggcatat cactctggag tttttagctg ctgtcctttc ccgatgaaca     8520

gtctgtatta gctgacctca gcctacttgt tacgtgacgt atgggtccca aaagtgtcct     8580

ttgtcaaaaa gcagaatgtg ccttctagtc tccctttccc catctaatgg tgtattcgat     8640

ggtgaagatg agtacagttg accaccccta tctgtgggtt ccacatccct atattcaacc     8700

aagtacagat tgaaaaatat ttggggaaga ggggaaaccc acaaagttcc aaaaagcaaa     8760

agttgaattt gccacatgct gaatactaca ttgaattcac acaaatgaag tgatgtgtag     8820

gcattgagtt aggtattgta aataatctag agatgattta aagtatgcaa gagatgtgca     8880

taggttatat gcaaatactg tgctatttta tataaaagac ttgaacatcc atggattctg     8940

gtattctcag agggtccttg attgccccct ttggtaaagg acaactattt cgttactgat     9000

tttcgtttgg ggaagatctg tcaatccctt gaggtgcggg ggttgggggg atggagggta     9060

cagggcattc taggatgtgt gccagggagc acagattcaa gggatgggat tgagtcagac     9120

ctgtgttctt actcagtgtc agaaataact ctgtggagct cctagagtaa gacatttccg     9180

gaagcaccac ataattactg ttgggctctt agggtagccc ttttagggaa ttgagcattc     9240

ccatgtttta ccaacaatta ttctgctgct gtgttttatt atattgccaa tggttttgag     9300

acactcatca tgctcttatt tagtgatttc ttttcatgag cagagcaaca gctcatccag     9360

catggtttcc aaatggagaa atttgggtct tctgtagaaa ccacacaaat tctccaatgg     9420

cctacagcct tatggttggc acactagttg gccctatagg gtggaaataa agctgtaaga     9480

tgttaaactg catttgatac ttctcttgaa cgctgagcaa ggaagcaaaa tagttcttgt     9540

ctttacttaa gcttctaaga cattttgggg caaaggacct tacagatggc gtctgttgaa     9600

agtaacagca acgtgccagg gagaaatgtg ggggaaatct catcaaattc tgccacctca     9660

aatgtgttgt ccagaagtca gtgttattca gggggccctg tgaaacttga ccaccagctt     9720

gcgccatcaa cactcagcct ttatccagcc tgctctcagc ttttgtgttt ctgttagaaa     9780

ctcagatagg taagtatttt tattcagtag actacctttc ttatcttttc agcttaatat     9840

agctgcatct tctttctcaa agccaaacta agatattctc tattaaaatg tccatgagcc     9900

tagcattgag tgtctggcat ccatcaattt catagactgg aaaatgattg ttgtttggta     9960

cagtaaagaa gaggatgtgc atcagttcct accgtttgca gctttgtttt tagccttccc    10020

attttaaaaa taaattcaag gacattgagt tacaaggcag gagggctgga gctactgggc    10080

agcctgaata tgacaagcat ttgtgtggaa agtcattgct ccttctgcca cactttgggc    10140

catcaggatc attctttccc agaagtgcca taaacttgct caaaagtttc tataaatggg    10200

aagagggaga ggaaggattt ttgcatcagt cctgaagttg ctatccaaaa gttctctgtt    10260

tcacaaataa ttttctgaac tctggaatgc ctctcctact ccctgcctcc ctttctgtaa    10320

tgtcagagtg atggaaacca ccaagtggca tgctagggaa agcctgcagc agtgttggag    10380

tctatttcac cctagctcat agttttaaac tgtcttcact gttgaggtag agcttgatga    10440

atgtcatgga ttatgatgtg tggtttatca tatttgcctg gatttgctga tcaaaagcac    10500

catcttccct cgcctgctgc tggcagcctt tccttgcctt gcttgttagc agagcattct    10560

gcttacccat gtggctccca gagttagcag ccccggctct tggatttctt gattcttctc    10620

ccctgtgatc tcagaggtgc tgcagaggac attccccttt agagcaagtc atgtttctat    10680

tcaggccaca aaactgggat gtacatgcag tgactttggt gttccttgtc ttgttcaggg    10740

gaacgggtgg gactgttgtg tgctgtcacc ctcttcattc catgagcacc ttgttcactt    10800

agggtctgct gccttttttt ttttcttttt cttttttttt ttttttttag tttttgagat    10860

cgtgtctcac tcctgttgcg caggctggag tgcagcctcc aaagtagctg ggattatagg    10920

cgtgcaccac cacacccggc taatttttat atttttagta gagacggggt tttgccatgt    10980

tggccagact ggtctcaaac ctctgacctc gtgatgaccc ccctcggcct cccaaagtgc    11040

tgggattaca cccagcctct gctgcctttt catatttccc catctgcttt atggatcaac    11100

tctcaacagt acactttttc ttttctttac ctaccctatg agtgcaaccc agatgtaaga    11160

gttaatcctc gtcagagaat cattgcctta aacctctcag aaatatgtaa ttaggaaatc    11220

ttattttaat tttttaaaaa ttgcttgtat agtttcaaag aataagatct ggcaaatggc    11280

cagatgtggt ggctcacacc tgtaatcaaa ccagcacttt gggaggctga ggcaggcaga    11340

tcacctgagg tcaggcgttc aagaccagcc tggccaacat ggtgaaatcc cgtctctact    11400

aaaaatacaa aaaaaaaaaa aaaaaaaaaa attagccagg catggtggca catgcctgta    11460

atcccagcta ctcaggaggc tgaggcagga taattgcttg aacccgggag gtggaggttg    11520

cagtgagccg agatcatgcc actgcactcc agcctgggca acagagtgag actttgtctc    11580

aaaaaaaaaa aaaaaaaaaa aaaaagatct ggcggatgaa aataaccaga atgaaaatag    11640

ctagaaaact cagcaagcag gaagctccct ttctcaccct tttgttccct tgccgataga    11700

atcagtcact attagaaaaa atgaaagacg ctctgtttaa aacaatgatg acagcagtac    11760

ttaatatgta tttcgaggtg aacttatata gattgagaga ggctgcattt ggcagactga    11820

tgtataggaa gacccatttg tttctagctt ctccctgcag ggaaaatgct ttcgtcatta    11880

tagcctcttt acacagactg gccattctag tgaaacaggt ggtaaacctt tgggctgccc    11940

agaaacattt tatctgtttt cacttaccta ggaaggggaa agattagcgg gtcatccaaa    12000

atctgtatgt aagctatctt cattttcttc cccaaccttc tcctcctggg aaacacaaat    12060

gctatctcat ctgacaaaag gttttagagg ataaagctga aaagattgga ttgggatctt    12120

tttgtggctt ggggcggagc cttttgctaa aatctcaaga atgctgcttt gagtttagct    12180

agggtggctc tcagaactgg ggtgcctggc attctcagca tttctcaggg gcctcccacc    12240

tctgacaact gcagtgttag ctaatacata ccttgagcat agaactgaat gctgtaattc    12300

agagccattt tttttttcaa cttgaacatt gtacaatttt actgcaattt cctttgaact    12360

ttcttgccac tgtttggaat cttaaaaatt cattagcctt ctcctttctg acataaagct    12420

actcttcatc agagatgagt tcctatgtat gtcctttgtt ccttcaatag ctaattaatg    12480

tgcttgagga tacttcagtg gaaaaaaagg tttaaatatg caaattacta ataaatgtgt    12540

aaccttatgt aacttgtgtt acatcaagta acaagctaat ctagtttgtt tcactggact    12600

aggcttgtgc tccctacttc agtattttga tgctttcctt gatctttgtt tcacaaaatg    12660

ttgtgaattt tggtatcatt caaaacaaat gacatttatt aggtttcatt ttgaaacgat    12720

gtacagacaa gtccccaact tagaaaccgg tttgttctta aggttcttgc gtcagcccat    12780

agaagcccac tgacctccac cacagcccaa atggagggct gtgatagcca gatctggttg    12840

gcttttgtgg gctgacccag acatttaatc accatctctt atgttgttgc cgtaagaaat    12900

gcattccagg ttgggacttg ggatcctgag agcacattcg ccccctgtgg tggccgcttg    12960

ccaccttgca agatggaagc ccagtctcct tactaccaaa ctgtagttgt aagcagaggg    13020

aggggtgaga tgtttatagg acattcccta agctggggag tgatttttat cactattcat    13080

gtcaactgta ctttggtata gactccctat caatttaata atatgaaaag cctaaaataa    13140

aactatgcat gctattctat gtgctatttt atatcagtaa ataagcttat gcttgccagt    13200

tgtatacaca gttatgaggt gtatagaact gactttgaca gtattttttg cactgtttcc    13260

tatctgtttt tataaagtct tatttagata ttggaccttg ttgatgttct cactgccctt    13320

gtgcttgcta taaaatgttt catatgtgcc tttacaaatg tgagatcttt attctaacct    13380

ttttttgtaa aagatatcta ttgatttcca tatgcaataa accttttttt cagagaaaag    13440

tta                                                                  13443


<210>  33
<211>  1415
<212>  DNA
<213>  Homo sapiens

<400>  33
attgaaggct gggcagagtc tgagtccacc cgggtcgtgc tccccccgct cgcccggctc       60

ctccgcagtc caggaatctc cccgtggctc tccccgacct ggaggggtgg acgcccctgg      120

cccccagtcc ccggcctgcg gagggggccg gtggctgcgg ccctgcgcgg ggccggggcg      180

ggccgagcca agggccgccc ccggccgacc ctccccctgc cgggcccgcc ctccccgccg      240

cggcgctgga ggagggcggg gcggggccct ggggtcagtc tgagcctccg gcaccggccg      300

cgcagctgga ggcggcggag cggaagcctt gacttcatct cagctccaga gcccgccctc      360

tcttcctgca gcctgggaac ttcagccggc tggagcccca ccatggctgc aatccgaaag      420

aagctggtga tcgttgggga tggtgcctgt gggaagacct gcctcctcat cgtcttcagc      480

aaggatcagt ttccggaggt ctacgtccct actgtctttg agaactatat tgcggacatt      540

gaggtggacg gcaagcaggt ggagctggct ctgtgggaca cagcagggca ggaagactat      600

gatcgactgc ggcctctctc ctacccggac actgatgtca tcctcatgtg cttctccatc      660

gacagccctg acagcctgga aaacattcct gagaagtgga ccccagaggt gaagcacttc      720

tgccccaacg tgcccatcat cctggtgggg aataagaagg acctgaggca agacgagcac      780

accaggagag agctggccaa gatgaagcag gagcccgttc ggtctgagga aggccgggac      840

atggcgaacc ggatcagtgc ctttggctac cttgagtgct cagccaagac caaggaggga      900

gtgcgggagg tgtttgagat ggccactcgg gctggcctcc aggtccgcaa gaacaagcgt      960

cggaggggct gtcccattct ctgagatccc caaggccttt cctacatgcc ccctcccttc     1020

acaggggtac agaaattatc cccctacaac cccagcctcc tgagggctcc atgctgaagg     1080

ctcccatttt cagttccctc ctgcccagga ctgcattgtt ttctagcccc gaggtggtgg     1140

cacgggccct ccctcccagc gctctgggag ccacgcctat gccctgccct tcctcagggc     1200

ccctggggat cttgccccct ttgaccttcc ccaaaggatg gtcacacacc agcactttat     1260

acacttctgg ctcacaggaa agtgtctgca gtaggggacc cagagtccca ggcccctgga     1320

gttgttttcg gcaggggcct tgtctctcac tgcatttggt caggggggca tgaataaagg     1380

ctacaggctc caacgtgaaa aaaaaaaaaa aaaaa                                1415


<210>  34
<211>  2977
<212>  DNA
<213>  Homo sapiens

<400>  34
agctggggta aggagttcaa ggcagcgccc acacccgggg gctctccgca acccgaccgc       60

ctgtccgctc ccccacttcc cgccctccct cccacctact cattcaccca cccacccacc      120

cagagccggg acggcagccc aggcgcccgg gccccgccgt ctcctcgccg cgatcctgga      180

cttcctcttg ctgcaggacc cggcttccac gtgtgtcccg gagccggcgt ctcagcacac      240

gctccgctcc gggcctgggt gcctacagca gccagagcag cagggagtcc gggacccggg      300

cggcatctgg gccaagttag gcgccgccga ggccagcgct gaacgtctcc agggccggag      360

gagccgcggg gcgtccgggt ctgagccgca gcaaatgggc tccgacgtgc gggacctgaa      420

cgcgctgctg cccgccgtcc cctccctggg tggcggcggc ggctgtgccc tgcctgtgag      480

cggcgcggcg cagtgggcgc cggtgctgga ctttgcgccc ccgggcgctt cggcttacgg      540

gtcgttgggc ggccccgcgc cgccaccggc tccgccgcca cccccgccgc cgccgcctca      600

ctccttcatc aaacaggagc cgagctgggg cggcgcggag ccgcacgagg agcagtgcct      660

gagcgccttc actgtccact tttccggcca gttcactggc acagccggag cctgtcgcta      720

cgggcccttc ggtcctcctc cgcccagcca ggcgtcatcc ggccaggcca ggatgtttcc      780

taacgcgccc tacctgccca gctgcctcga gagccagccc gctattcgca atcagggtta      840

cagcacggtc accttcgacg ggacgcccag ctacggtcac acgccctcgc accatgcggc      900

gcagttcccc aaccactcat tcaagcatga ggatcccatg ggccagcagg gctcgctggg      960

tgagcagcag tactcggtgc cgcccccggt ctatggctgc cacaccccca ccgacagctg     1020

caccggcagc caggctttgc tgctgaggac gccctacagc agtgacaatt tataccaaat     1080

gacatcccag cttgaatgca tgacctggaa tcagatgaac ttaggagcca ccttaaaggg     1140

ccacagcaca gggtacgaga gcgataacca cacaacgccc atcctctgcg gagcccaata     1200

cagaatacac acgcacggtg tcttcagagg cattcaggat gtgcgacgtg tgcctggagt     1260

agccccgact cttgtacggt cggcatctga gaccagtgag aaacgcccct tcatgtgtgc     1320

ttacccaggc tgcaataaga gatattttaa gctgtcccac ttacagatgc acagcaggaa     1380

gcacactggt gagaaaccat accagtgtga cttcaaggac tgtgaacgaa ggttttctcg     1440

ttcagaccag ctcaaaagac accaaaggag acatacaggt gtgaaaccat tccagtgtaa     1500

aacttgtcag cgaaagttct cccggtccga ccacctgaag acccacacca ggactcatac     1560

aggtgaaaag cccttcagct gtcggtggcc aagttgtcag aaaaagtttg cccggtcaga     1620

tgaattagtc cgccatcaca acatgcatca gagaaacatg accaaactcc agctggcgct     1680

ttgaggggtc tccctcgggg accgttcagt gtcccaggca gcacagtgtg tgaactgctt     1740

tcaagtctga ctctccactc ctcctcacta aaaaggaaac ttcagttgat cttcttcatc     1800

caacttccaa gacaagatac cggtgcttct ggaaactacc aggtgtgcct ggaagagttg     1860

gtctctgccc tgcctacttt tagttgactc acaggccctg gagaagcagc taacaatgtc     1920

tggttagtta aaagcccatt gccatttggt gtggattttc tactgtaaga agagccatag     1980

ctgatcatgt ccccctgacc cttcccttct ttttttatgc tcgttttcgc tggggatgga     2040

attattgtac cattttctat catggaatat ttataggcca gggcatgtgt atgtgtctgc     2100

taatgtaaac tttgtcatgg tttccattta ctaacagcaa cagcaagaaa taaatcagag     2160

agcaaggcat cgggggtgaa tcttgtctaa cattcccgag gtcagccagg ctgctaacct     2220

ggaaagcagg atgtagttct gccaggcaac ttttaaagct catgcatttc aagcagctga     2280

agaaaaaatc agaactaacc agtacctctg tatagaaatc taaaagaatt ttaccattca     2340

gttaattcaa tgtgaacact ggcacactgc tcttaagaaa ctatgaagat ctgagatttt     2400

tttgtgtatg tttttgactc ttttgagtgg taatcatatg tgtctttata gatgtacata     2460

cctccttgca caaatggagg ggaattcatt ttcatcactg ggagtgtcct tagtgtataa     2520

aaaccatgct ggtatatggc ttcaagttgt aaaaatgaaa gtgactttaa aagaaaatag     2580

gggatggtcc aggatctcca ctgataagac tgtttttaag taacttaagg acctttgggt     2640

ctacaagtat atgtgaaaaa aatgagactt actgggtgag gaaatccatt gtttaaagat     2700

ggtcgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttg tgttgtgttt tgttttttaa     2760

gggagggaat ttattattta ccgttgcttg aaattactgt gtaaatatat gtctgataat     2820

gatttgctct ttgacaacta aaattaggac tgtataagta ctagatgcat cactgggtgt     2880

tgatcttaca agatattgat gataacactt aaaattgtaa cctgcatttt tcactttgct     2940

ctcaattaaa gtctattcaa aaggaaaaaa aaaaaaa                              2977


<210>  35
<211>  4102
<212>  DNA
<213>  Homo sapiens

<400>  35
cggctatccg cgcgggagtg cgccacgcgg ggccggagcg cctattagcc gccaggacct       60

cggagcgccc cgaccacccc tgagcccctc tggcttcgga gccccccagc accccttccc      120

gggtcccctc gcccacccta atccactctc cctccctttc ccggattccc tcgctcaccc      180

catcctctct cccgcccctt cctggattcc ctcacccgtc tcgatcccct ctccgccctt      240

tcccagagac ccagagcccc tgaccccccg cgccctcccc ggagcccccc gcgcgtgccg      300

cggccatggc ggccgtgcgc ggggcgcccc tgctcagctg cctcctggcg ttgctggccc      360

tgtgccctgg agggcgcccg cagacggtgc tgaccgacga cgagatcgag gagttcctcg      420

agggcttcct gtcagagcta gaacctgagc cccgggagga cgacgtggag gccccgccgc      480

ctcccgagcc caccccgcgg gtccgaaaag cccaggcggg gggcaagcca gggaagcggc      540

cagggacggc cgcagaagtg cctccggaaa agaccaaaga caaagggaag aaaggcaaga      600

aagacaaagg ccccaaggtg cccaaggagt ccttggaggg gtcccccagg ccgcccaaga      660

aggggaagga gaagccaccc aaggccacca agaagcccaa ggagaagcca cctaaggcca      720

ccaagaagcc caaggagaag ccacccaagg ccaccaagaa gcccaaagag aagccaccca      780

aggccaccaa gaagcccccg tcagggaaga ggccccccat tctggctccc tcagaaaccc      840

tggagtggcc actgccccca ccccccagcc ctggccccga ggagctaccc caggagggag      900

gggcgcccct ctcaaataac tggcagaatc caggagagga gacccatgtg gaggcacggg      960

agcaccagcc tgagccggag gaggagaccg agcaacccac actggactac aatgaccaga     1020

tcgagaggga ggactatgag gactttgagt acattcggcg ccagaagcaa cccaggccac     1080

ccccaagcag aaggaggagg cccgagcggg tctggccaga gccccctgag gagaaggccc     1140

cggccccagc cccggaggag aggattgagc ctcctgtgaa gcctctgctg cccccgctgc     1200

cccctgacta tggtgatggt tacgtgatcc ccaactacga tgacatggac tattactttg     1260

ggcctcctcc gccccagaag cccgatgctg agcgccagac agacgaagag aaggaggagc     1320

tgaagaaacc caaaaaggag gacagcagcc ccaaggagga gaccgacaag tgggcagtgg     1380

agaagggcaa ggaccacaaa gagccccgaa agggcgagga gttggaggag gagtggacgc     1440

ctacggagaa agtcaagtgt ccccccattg ggatggagtc acaccgtatt gaggacaacc     1500

agatccgagc ctcctccatg ctgcgccacg gcctgggggc acagcgcggc cggctcaaca     1560

tgcagaccgg tgccactgag gacgactact atgatggtgc gtggtgtgcc gaggacgatg     1620

ccaggaccca gtggatagag gtggacacca ggaggactac ccggttcaca ggcgtcatca     1680

cccagggcag agactccagc atccatgacg attttgtgac caccttcttc gtgggcttca     1740

gcaatgacag ccagacatgg gtgatgtaca ccaacggcta tgaggaaatg acctttcatg     1800

ggaacgtgga caaggacaca cccgtgctga gtgagctccc agagccggtg gtggctcgtt     1860

tcatccgcat ctacccactc acctggaatg gcagcctgtg catgcgcctg gaggtgctgg     1920

ggtgctctgt ggcccctgtc tacagctact acgcacagaa tgaggtggtg gccaccgatg     1980

acctggattt ccggcaccac agctacaagg acatgcgcca gctcatgaag gtggtgaacg     2040

aggagtgccc caccatcacc cgcacttaca gcctgggcaa gagctcacga ggcctcaaga     2100

tctatgccat ggagatctca gacaaccctg gggagcatga actgggggag cccgagttcc     2160

gctacactgc tgggatccat ggcaacgagg tgctgggccg agagctgttg ctgctgctca     2220

tgcagtacct gtgccgagag taccgcgatg ggaacccacg tgtgcgcagc ctggtgcagg     2280

acacacgcat ccacctggtg ccctcactga accctgatgg ctacgaggtg gcagcgcaga     2340

tgggctcaga gtttgggaac tgggcgctgg gactgtggac tgaggagggc tttgacatct     2400

ttgaagattt cccggatctc aactctgtgc tctggggagc tgaggagagg aaatgggtcc     2460

cctaccgggt ccccaacaat aacttgccca tccctgaacg ctacctttcg ccagatgcca     2520

cggtatccac ggaggtccgg gccatcattg cctggatgga gaagaacccc ttcgtgctgg     2580

gagcaaatct gaacggcggc gagcggctag tatcctaccc ctacgatatg gcccgcacgc     2640

ctacccagga gcagctgctg gccgcagcca tggcagcagc ccggggggag gatgaggacg     2700

aggtctccga ggcccaggag actccagacc acgccatctt ccggtggctt gccatctcct     2760

tcgcctccgc acacctcacc ttgaccgagc cctaccgcgg aggctgccaa gcccaggact     2820

acaccggcgg catgggcatc gtcaacgggg ccaagtggaa cccccggacc gggactatca     2880

atgacttcag ttacctgcat accaactgcc tggagctctc cttctacctg ggctgtgaca     2940

agttccctca tgagagtgag ctgccccgcg agtgggagaa caacaaggag gcgctgctca     3000

ccttcatgga gcaggtgcac cgcggcatta agggggtggt gacggacgag caaggcatcc     3060

ccattgccaa cgccaccatc tctgtgagtg gcattaatca cggcgtgaag acagccagtg     3120

gtggtgatta ctggcgaatc ttgaacccgg gtgagtaccg cgtgacagcc cacgcggagg     3180

gctacacccc gagcgccaag acctgcaatg ttgactatga catcggggcc actcagtgca     3240

acttcatcct ggctcgctcc aactggaagc gcatccggga gatcatggcc atgaacggga     3300

accggcctat cccacacata gacccatcgc gccctatgac cccccaacag cgacgcctgc     3360

agcagcgacg cctacaacac cgcctgcggc ttcgggcaca gatgcggctg cggcgcctca     3420

acgccaccac caccctaggc ccccacactg tgcctcccac gctgccccct gcccctgcca     3480

ccaccctgag cactaccata gagccctggg gcctcatacc gccaaccacc gctggctggg     3540

aggagtcgga gactgagacc tacacagagg tggtgacaga gtttgggacc gaggtggagc     3600

ccgagtttgg gaccaaggtg gagcccgagt ttgagaccca gttggagcct gagtttgaga     3660

cccagctgga acccgagttt gaggaagagg aggaggagga gaaagaggag gagatagcca     3720

ctggccaggc attccccttc acaacagtag agacctacac agtgaacttt ggggacttct     3780

gagatcagcg tcctaccaag accccagccc aactcaagct acagcagcag cacttcccaa     3840

gcctgctgac cacagtcaca tcacccatca gcacatggaa ggcccctggt atggacactg     3900

aaaggaaggg ctggtcctgc ccctttgagg gggtgcaaac atgactggga cctaagagcc     3960

agaggctgtg tagaggctcc tgctccacct gccagtctcg taagagatgg ggttgctgca     4020

gtgttggagt aggggcagag ggagggagcc aaggtcactc caataaaaca agctcatggc     4080

acggacaaaa aaaaaaaaaa aa                                              4102


<210>  36
<211>  8532
<212>  DNA
<213>  Homo sapiens

<400>  36
aacatttaca acaaagttga ttctgtgtag ggttggaggc tagacagttc cacaaatttt       60

tagtcacatt ttccatgtca gttaaatcta gggagttcaa gactactgga aaaattagtc      120

tcattactaa aagaaactta gagaccgagg gaggtaccag agtctaggag gtacctctgg      180

gttgcagaag taattgtaaa ataccagacc tgttcttttt actaaaagct agtttcacta      240

tcttctggtc tgaaatactg aggcaaatac tcaagactta ttttcttcct aatcttgctg      300

gtgaaacaga agttactaga aagaaaggaa gaaaaaactt gatttggtga ctgcaggaag      360

caacacgttg ctgcttttat tctacagata atgatttatg aggaatccaa gatgaatttg      420

gagcaggaga ggccgtttgt ctgcagtgcc ccaggctgct cccagcgctt cccaacagag      480

gaccatctga tgattcatag gcacaaacat gaaatgactt tgaagtttcc ttcaataaaa      540

acagacaata tgttatcaga tcaaactccg accccaacga gattcctgaa gaactgcgag      600

gaggtgggcc tcttcagcga gctggactgc tccctggagc acgagttcag gaaggctcag      660

gaagaggaga gcagcaagcg gaatatctcg atgcataatg cagttggtgg ggccatgacg      720

gggcccggaa ctcaccagct tagcagcgct cggctgccca accatgacac caacgttgtg      780

attcagcaag ccatgccgtc gcctcagtcc agctctgtca tcactcaggc accttccacc      840

aaccgccaga tcgggcctgt cccaggctct ctatcttctc tgctacatct ccacaacaga      900

cagagacagc ccatgccagc ctccatgcct gggaccctgc ccaaccctac aatgccagga      960

tcttccgccg tcttgatgcc aatggagcga caaatgtcag tgaactccag catcatgggg     1020

atgcaaggtc caaatctcag caacccctgt gcttctcccc aggtccagcc aatgcattca     1080

gaagccaaaa tgaggttgaa ggctgcattg actcaccacc ctgctgccat gtcaaatggg     1140

aacatgaaca ccatgggaca catgatggag atgatgggct cccggcagga ccagacgcca     1200

caccatcaca tgcactcgca cccgcatcag caccagacac tgccacccca tcacccttac     1260

ccacaccagc accagcaccc agcacaccat cctcaccctc aaccccatca ccagcagaac     1320

catccacatc accactccca ttcccacctt catgcacacc cagcacatca ccagacctcg     1380

ccacatccgc ccctgcacac cggcaaccaa gcacaggttt caccagcaac acaacagatg     1440

cagccaaccc agacaataca gccaccccag cccacagggg ggcgccggcg aagggtggta     1500

gacgaggatc cggacgagag gcggcggaaa tttctggaac ggaaccgggc agctgccacc     1560

cgctgcagac agaagaggaa ggtctgggtg atgtcattgg aaaagaaagc agaagaactc     1620

acccagacaa acatgcagct tcagaatgaa gtgtctatgt tgaaaaatga ggtggcccag     1680

ctgaaacagt tgttgttaac acataaagac tgcccaataa cagccatgca gaaagaatca     1740

caaggatatc taagtccaga gagtagccct cctgctagtc ctgtcccagc ttgctcccag     1800

caacaagtca tccagcataa taccatcact acttcctcat cggtcagcga ggtggtagga     1860

agctccaccc tcagccagct caccactcac agaacagacc tgaatccgat tctttaaaat     1920

gcaccatcag acctggcctc caagaagagc tgtagcgtac catgcgtcct ttcttttaag     1980

ggcattttta gaattaactc agacctggaa gactcctcag ttcttcaaag actggctttc     2040

atttttatag ttattatgga aatgttgtct tttatactta gttatataag aaaaaaggga     2100

gttatgcaat taatatctat cagcttggga aacgctttgg tgcttttctc cagttttctg     2160

gtaccagtta cttgtttata aactgaacct tttctgtata tagccatggt ttcattctta     2220

tcagtccaac cctttgcctg aaacattgaa tcttgttaaa ccacagcttt tagctaaaat     2280

gaggtatacc tagatgtcaa gtaagacaga tccaaggtaa ctgggtagga aatcttttga     2340

catcttaact catgttgagt ttgtgctgtg gtgtcaccag aattccagat aaacacacag     2400

cctttcccat accttttttt ttcttactat aaaatattat aagatccatt gatgtccaaa     2460

taataccacc aagcatctct tcacctctcc tcctcttggt ccacttgcta atgcccagtt     2520

ttcttctcca tttccacttt ttcttaggct ccctatttac tattcatttt gacttccttc     2580

tgttttattt ttttcccttt agcattgcat gtgaataaga aaataatgtt taaagaaaaa     2640

aaaaaaaaag caaacctcca aaacgtggac ctaaccattg cttcacttac acttcaccca     2700

cagctggagt tcattcaact cttgcttttc acaaaatagt aaccaggaga tgtttaatgt     2760

gcctgattta atgtttttaa taatcacagc aaatgaaagg tggtttagtt ataagtgaag     2820

catggttgaa taccagctgg ggagacacta gggaagggag ctttgtaagc cttgattgcg     2880

aaagtccaaa ttttgatgtg gggctataac atgacaccct tggattgcga ctggttttat     2940

acggcctgcc tataacgttg aaaatccatg tactacataa taattcagaa gggctctatt     3000

cactacacag attacattgt tcaatcatca gctgctaata gcctaagatt tatttttttt     3060

tttttcttaa gcctatggaa ccggctttgc tgttctgggg ggtgaaaata gactaactac     3120

tggagaaaca aagagagaaa gaaaacccag tgtttccata ggggcacttt tagccttccc     3180

acaacagtta agcactcttt gactgctgaa ggaaccccat ggatgaggtg caggctactt     3240

cactcttttt ttttcttttt tgagacagag tctcacctat tgcccagact gaagtgcagt     3300

ggtgcgatca tggatcactg cagcagcatc ctccgagttc aagctatcct tccacctccg     3360

cctcctgagt agctgggacc acaggttcac ataaccatgc ctggctaatt tatttttact     3420

tttattttaa aataaaagat gaggtctgtc ttatgttgcc caggctggtc tcaaactatc     3480

ctacttcttc ctcccaaagt gttgggatta taggtgtgag ccactgcacc cagcctactt     3540

cactcttctg aattattctg atttattttc aacaactttt gtgaacttgc ccgtgataca     3600

aagcagatag tccctgaacc acagtcgtgc ctccttgaaa caagccattc tactgtgcta     3660

atgttttaat atcacatctc acaaataaca ggggtgaatg tttctctcta gcaatctagg     3720

caggtgctgg tgtttcatct ccatttgaat gcttgacctc ttaatgtgtg tgtgtgtgtg     3780

tgtgtgtgtg tgtgtgttca tgggttttaa aagaacagta ttttacaaaa ggtgtagctt     3840

ttataagagt gcagaaaagg gaaggatgtg tttttttctc tcactatagt ataagaatct     3900

attttggaga aaaaaagaaa atatgagggt ctcgaagcat gatttttata taactagttt     3960

cagttttatc taataactta ctttttaaat caatatttat caacaatctt tccttgtatg     4020

cagtgctttc aaaagatggt tttgagtgtc cagtgaaact tatgacttgg atatatggtt     4080

gaagaatcaa aacaaaagca aaaaaaaaaa gcaaaaaaag aaaagagaaa aaaagaaaaa     4140

atgcaaatgg aataattttc tattatattt tagacaaaca tatcattttc gagtatttta     4200

aatactgaat tcatagttgt tgttttttaa attccaacag taacagctga atggtttaat     4260

ctgactggct tcctaagaaa tgtttaagac tcagctttaa aaagaagtta acattcatat     4320

ctctgttttg aaatcaaaaa tcatatttca aaattctttc ctaggaccat ctatgtgtct     4380

cccctcccct ccacaaaaag gagaaagagt gcattaaaat gtttagttgg gttttttaat     4440

ttttaatttt tatgttatgt tttgctttgt tttaagtaaa caaaaatttt tctttcttta     4500

ctgcatgcat agcacttaat aaaatggatt tttaaaaaat ccactagtaa tatcagaatg     4560

tccagggagt gactgtcact acaatgatgg tttagtttac ttctgttcca ccttttgatt     4620

gaaatattta gttgttaggc tgaaagcctc ggcagttaag aacttgcctg agttttcttc     4680

gttcagcaac ttgacagttt gactgatgtg cattatatat agctcaatta tgtctgtttt     4740

ttatgctaag taggaaaacc aaccacacac attagcaaac cggcctcaac atataattag     4800

aataaactgt cttcttgttc tactcagggc ctttaggtgt gttcattcac ggtatggaaa     4860

tacagtaaat gaaagattcc aactagttgt cagtgcttct tgaaattcca aacagaaaga     4920

tacattggtc aaatccaaca cttggcttat caatattaag tcttttacct aaaggcccag     4980

ccgtcaccag acaacagaat aatcaatctg cctgaaaatc cctcctcctt gtcctacact     5040

ttttgcctgt ttgggagaat atctttgtac tccattctcc tccctcagcc agttactggg     5100

tcacccatcc atgtgttcat gaatcaatca tcacggcctg cagagcacct gtcctaagga     5160

gggaaaatcc tgtcacactg cctctcccca ttcgtgtgtg gttttcttga tcggtgagat     5220

ctgtctctga agtcactgcc agcctccctg ggaacgtcta tagtgcctcc cctgccttat     5280

gtgatgggag ttaacaactc agataagtac acctgagagc atttctatca ggtaaactgt     5340

cacttaaatg gaggtgtcca catcttaatt gtttctcctt gacacatttc tcaatccacg     5400

aagccaggag aggtagagtg aaaatcccag ccatggatga atgtactaat ttgaaagcca     5460

agtgttaagt cggatgtttt cccgttacac tactactcag ccctctcctg cggccacatc     5520

aacggatgca agtcacagtc ttaacacagc ctgtgggaga caagcagttt gtgtgctcac     5580

agtatatatt atagtaatta gggtgactta gagcaaatac tcttcagatc ctatgtagtc     5640

agtgaaacaa aatggagagc gtattctgat agaaggacgt cgacggtgaa tgttctggtg     5700

gttgttgcct gttaagtaaa ctttagtgtg taagttgagt ttgtcattaa aatcataaac     5760

cagctgcggt aacagacaag cctttggctg gggagtttta agcctcggta actgctataa     5820

aactagccat ccagttagga tagaatgtgt ttctttctgg ttaaaaaaag gaaaaaccat     5880

ctaagaaaat atatatgtat gtatgtgtgt atacagtgga attcaaagga ccaaagcaaa     5940

atttgaacag gaatctatta atttagaatt ttataagata tttattaata aatgttattt     6000

ttaaacattc catttgaaca gtattctgta ggatctactt gtttttaaag tgttagtcca     6060

taataaacta ctatagttat gtgtattttc atttttcagg gtttcaaatg gctattctcc     6120

atcatttggt ggaaatgttt gcttagatct ctgtgcatag acatttcaag gatttttatt     6180

gctctgtgag ttatttttta atcaacattc tgaacagttt tttttaaaca tttatttctg     6240

tgtgttcatt tttaaagtaa gctctttcat ttaggaagca gagttcagct aaagggaatc     6300

agtaactcta actggaacag ctttcttgta gaagtgtaaa aacagcttca tctctgcctc     6360

tctccacccc accccaattt cctagaaagc cttgcactat tcagctccct tagtgctttt     6420

tgtcccttcc cgaacaatat gcagtagctt taagccattc aagctccatt atgcagtata     6480

tctgagaagg gaaaggaaac aacccattta aatttgaata aaaccgtgcc tatgcgaaca     6540

gtagcaattt agaatctctt ttctgctttt aaaataattt atatttaaaa attgcacttt     6600

agctttttga tccctttgta tttctcttat tctctttcta acctcttctc tgtcctcaaa     6660

cttgcctttg ctctccttta caataccccc cacccctcct ccaaggctct gagcggcatc     6720

atttaaaata ctttacagat atttgcacca ggtacattta tgtgcgtcca ttggtagcac     6780

agctgagacc tgtgtctcac atcagcctag gtgaagccta ctacaagaat gccaaggaga     6840

agagccagta cactatatgg tttatactct ttatcccttt attcatagca tgttttttaa     6900

aaatgttata ttatgcaaca gatgtgaggc agcagctaag ctatacttaa gaattttctc     6960

tcaccttcca aaccaaagtg tcctgaataa gccaggagac ttattctttt gtgcaccctg     7020

gtgcacatct gactgttgtc ctagccatag actctctgag gccactgaaa gaacagtggc     7080

cctatcgatt tcattcctag gtctcaaaaa tacaatgttg ccttgtaaca taattaggga     7140

cagcacctct atttcacaat tataatctaa ggtaggataa gacgacacag cagcaataaa     7200

cttacaagta aaattcaata ccaaaacaaa cacaaagaaa tttaaaaaac aaaaaaccta     7260

gctcatcatg ttgtgaaaat gaaaaagtga atgtccattc aaaatatttt actatttctt     7320

gtggagtttt tcagtgatgt aatgcttgta gccaaattgc ttaaagagtg tttatatatt     7380

tttttcctta taaattgtct attttttaaa aaagctattt aaccacagct gaagtggggg     7440

gtaaggccaa attgccaaca cttgttaaaa gattaatact cttaagtggc actctgatac     7500

ctttccaact tgtcatcaga aaggaatcaa taattaccaa ctgttgtatt tagaccaact     7560

tacaatatct agctcattag aagccaggat ctagaaagct ccttctaagc catttaagat     7620

attcttacat tgagcttcat attatagaac tttataggat tggatatttt acaatagaat     7680

aatttagcct caggactgag aatgtggaag ctgaataaat tagctttaaa tacatcatta     7740

aaatcttatg cacaataagc tcattagatt ctagttttct cctttagaat accaatgcca     7800

cagacactac aggagataat gaaaggtatc agttgtgttg agtggaggga gtttaagaga     7860

aaggaccctt cccaaccagc agccagtaga aaatacaacc tactcacctt tttcccttct     7920

aagttctgct aaatcacatc tgcctcatag agaaaggaat gttgcctttg agaactgtct     7980

tggagaacag ataagcttga aatgttctct ctagagagga catagggttt gggatcctct     8040

gaaaaggccc agaaaaatag ctcagttcaa atacaatgtt ctaggacaat tggaatataa     8100

atattgtcca aaaatataat taaaagaaaa aagtttagca ctgtgtaaag taagtgttaa     8160

ctgaggaagt cccaaaaagg tgctgtcact ttaagttctg gacttggggt tctttgtatt     8220

tgtaaacagc aaagcatttg tgtttgtttg tctatttgta aagcaaccac cttccttatt     8280

ggaaggagaa aaaaaggggt acatacatgt aaatacttgc tgcagcattt aatatgttta     8340

attttgtgtt aagctttttg ttgcatcgtg aacacattta ttgttaccaa tggacaatga     8400

gttcattaag actgttcaac taggtcagat ttttacatct ctttctagca agaagagaca     8460

agattttgtg catttgtaca aatgttaata tcactgcaat tccaatataa taaagcactc     8520

aaatgcaaat aa                                                         8532


<210>  37
<211>  4945
<212>  DNA
<213>  Homo sapiens

<400>  37
ttcatttccc agacttagca caatctcatc cgctctaaac aacctcatca aaactacttt       60

ctggtcagag agaagcaata attattatta acatttatta acgatcaata aacttgatcg      120

cattatggcc agcactatta aggaagcctt atcagttgtg agtgaggacc agtcgttgtt      180

tgagtgtgcc tacggaacgc cacacctggc taagacagag atgaccgcgt cctcctccag      240

cgactatgga cagacttcca agatgagccc acgcgtccct cagcaggatt ggctgtctca      300

acccccagcc agggtcacca tcaaaatgga atgtaaccct agccaggtga atggctcaag      360

gaactctcct gatgaatgca gtgtggccaa aggcgggaag atggtgggca gcccagacac      420

cgttgggatg aactacggca gctacatgga ggagaagcac atgccacccc caaacatgac      480

cacgaacgag cgcagagtta tcgtgccagc agatcctacg ctatggagta cagaccatgt      540

gcggcagtgg ctggagtggg cggtgaaaga atatggcctt ccagacgtca acatcttgtt      600

attccagaac atcgatggga aggaactgtg caagatgacc aaggacgact tccagaggct      660

cacccccagc tacaacgccg acatccttct ctcacatctc cactacctca gagagactcc      720

tcttccacat ttgacttcag atgatgttga taaagcctta caaaactctc cacggttaat      780

gcatgctaga aacacagggg gtgcagcttt tattttccca aatacttcag tatatcctga      840

agctacgcaa agaattacaa ctaggccaga tttaccatat gagcccccca ggagatcagc      900

ctggaccggt cacggccacc ccacgcccca gtcgaaagct gctcaaccat ctccttccac      960

agtgcccaaa actgaagacc agcgtcctca gttagatcct tatcagattc ttggaccaac     1020

aagtagccgc cttgcaaatc caggcagtgg ccagatccag ctttggcagt tcctcctgga     1080

gctcctgtcg gacagctcca actccagctg catcacctgg gaaggcacca acggggagtt     1140

caagatgacg gatcccgacg aggtggcccg gcgctgggga gagcggaaga gcaaacccaa     1200

catgaactac gataagctca gccgcgccct ccgttactac tatgacaaga acatcatgac     1260

caaggtccat gggaagcgct acgcctacaa gttcgacttc cacgggatcg cccaggccct     1320

ccagccccac cccccggagt catctctgta caagtacccc tcagacctcc cgtacatggg     1380

ctcctatcac gcccacccac agaagatgaa ctttgtggcg ccccaccctc cagccctccc     1440

cgtgacatct tccagttttt ttgctgcccc aaacccatac tggaattcac caactggggg     1500

tatatacccc aacactaggc tccccaccag ccatatgcct tctcatctgg gcacttacta     1560

ctaaagacct ggcggaggct tttcccatca gcgtgcattc accagcccat cgccacaaac     1620

tctatcggag aacatgaatc aaaagtgcct caagaggaat gaaaaaagct ttactggggc     1680

tggggaagga agccggggaa gagatccaaa gactcttggg agggagttac tgaagtctta     1740

ctacagaaat gaggaggatg ctaaaaatgt cacgaatatg gacatatcat ctgtggactg     1800

accttgtaaa agacagtgta tgtagaagca tgaagtctta aggacaaagt gccaaagaaa     1860

gtggtcttaa gaaatgtata aactttagag tagagtttgg aatcccacta atgcaaactg     1920

ggatgaaact aaagcaatag aaacaacaca gttttgacct aacataccgt ttataatgcc     1980

attttaagga aaactacctg tatttaaaaa tagaaacata tcaaaaacaa gagaaaagac     2040

acgagagaga ctgtggccca tcaacagacg ttgatatgca actgcatggc atgtgctgtt     2100

ttggttgaaa tcaaatacat tccgtttgat ggacagctgt cagctttctc aaactgtgaa     2160

gatgacccaa agtttccaac tcctttacag tattaccggg actatgaact aaaaggtggg     2220

actgaggatg tgtatagagt gagcgtgtga ttgtagacag aggggtgaag aaggaggagg     2280

aagaggcaga gaaggaggag accagggctg ggaaagaaac ttctcaagca atgaagactg     2340

gactcaggac atttggggac tgtgtacaat gagttatgga gactcgaggg ttcatgcagt     2400

cagtgttata ccaaacccag tgttaggaga aaggacacag cgtaatggag aaaggggaag     2460

tagtagaatt cagaaacaaa aatgcgcatc tctttctttg tttgtcaaat gaaaatttta     2520

actggaattg tctgatattt aagagaaaca ttcaggacct catcattatg tgggggcttt     2580

gttctccaca gggtcaggta agagatggcc ttcttggctg ccacaatcag aaatcacgca     2640

ggcattttgg gtaggcggcc tccagttttc ctttgagtcg cgaacgctgt gcgtttgtca     2700

gaatgaagta tacaagtcaa tgtttttccc cctttttata taataattat ataacttatg     2760

catttataca ctacgagttg atctcggcca gccaaagaca cacgacaaaa gagacaatcg     2820

atataatgtg gccttgaatt ttaactctgt atgcttaatg tttacaatat gaagttatta     2880

gttcttagaa tgcagaatgt atgtaataaa ataagcttgg cctagcatgg caaatcagat     2940

ttatacagga gtctgcattt gcactttttt tagtgactaa agttgcttaa tgaaaacatg     3000

tgctgaatgt tgtggatttt gtgttataat ttactttgtc caggaacttg tgcaagggag     3060

agccaaggaa ataggatgtt tggcacccaa atggcgtcag cctctccagg tccttcttgc     3120

ctcccctcct gtcttttatt tctagcccct tttggaacag aaggaccccg ggtttcacat     3180

tggagcctcc atatttatgc ctggaatgga aagaggccta tgaagctggg gttgtcattg     3240

agaaattcta gttcagcacc tggtcacaaa tcacccttaa ttcctgctat gattaaaata     3300

catttgttga acagtgaaca agctaccact cgtaaggcaa actgtattat tactggcaaa     3360

taaagcgtca tggatagctg caatttctca ctttacagaa acaagggata acgtctagat     3420

ttgctgcggg gtttctcttt caggagctct cactaggtag acagctttag tcctgctaca     3480

tcagagttac ctgggcactg tggcttggga ttcactagcc ctgagcctga tgttgctggc     3540

tatcccttga agacaatgtt tatttccata atctagagtc agtttccctg ggcatctttt     3600

ctttgaatca caaatgctgc caaccttggt ccaggtgaag gcaactcaaa aggtgaaaat     3660

acaaggtgac cgtgcgaagg cgctagccga aacatcttag ctgaataggt ttctgaactg     3720

gcccttttca tagctgtttc agggcctgtt tttttcacgt tgcagtcctt ttgctatgat     3780

tatgtgaagt tgccaaacct ctgtgctgtg gatgttttgg cagtgggctt tgaagtcggc     3840

aggacacgat taccaatgct cctgacaccc cgtgtcattt ggattagacg gagcccaacc     3900

atccatcatt ttgcagcagc ctgggaaggc ccacaaagtg cccgtatctc cttagggaaa     3960

ataaataaat acaatcatga aagctggcag ttaggctgac ccaaactgtg ctaatggaaa     4020

agatcagtca tttttatttt ggaatgcaaa gtcaagacac acctacattc ttcatagaaa     4080

tacacattta cttggataat cactcagttc tctcttcaag actgtctcat gagcaagatc     4140

ataaaaacaa gacatgatta tcatattcaa ttttaacaga tgttttccat tagatccctc     4200

aaccctccac ccccagtcca ggttattagc aagtcttatg agcaactggg ataattttgg     4260

ataacatgat aatactgagt tccttcaaat acataattct taaattgttt caaaatggca     4320

ttaactctct gttactgttg taatctaatt ccaaagcccc ctccaggtca tattcataat     4380

tgcatgaacc ttttctctct gtttgtccct gtctcttggc ttgccctgat gtatactcag     4440

actcctgtac aatcttactc ctgctggcaa gagatttgtc ttcttttctt gtcttcaatt     4500

ggctttcggg ccttgtatgt ggtaaaatca ccaaatcaca gtcaagactg tgtttttgtt     4560

cctagtttga tgcccttatg tcccggaggg gttcacaaag tgctttgtca ggactgctgc     4620

agttagaagg ctcactgctt ctcctaagcc ttctgcacag atgtggcacc tgcaacccag     4680

gagcaggagc cggaggagct gccctctgac agcaggtgca gcagagatgg ctacagctca     4740

ggagctggga aggtgatggg gcacagggaa agcacagatg ttctgcagcg ccccaaagtg     4800

acccattgcc tggagaaaga gaagaaaata ttttttaaaa agctagttta tttagcttct     4860

cattaattca ttcaaataaa gtcgtgaggt gactaattag agaataaaaa ttactttgga     4920

ctactcaaaa atacaccaaa aaaaa                                           4945


<210>  38
<211>  4015
<212>  DNA
<213>  Homo sapiens

<400>  38
cgaacgagcg gcgctcggcg gggacagaaa gagggagaga gagagagaga gagagggaga       60

ggcgcggccg ggcgaggcgg gcccgtccgg gagcgggctc cggggaaggg gtgcgggtct      120

gggcgccgga gcggggagcg gggccgcgtc cctctcagcg ccagctctac ttgagcccca      180

cgagccgctg tccccctggc gcgctcgggg ccgcgggacg ggcgcacgcc gccttctcct      240

agtcaagtat ccgagccgcc ccgaaactcg ggcggcgagt cggccacggg aagtttattc      300

tccggctcct tttctaaaag gaagaaacag aagtttctcc cagcggacag cttttctttc      360

cgcctttttg gccctgtctg aaatcggggg tccccagggc tggcaggcca ggctcgctgg      420

gctcctaatc ttttttttaa tttccaattt ttgattgggc cgtgggtccc cgctgagctc      480

cggctgcgcg cgggggcggg agggcgcgcg caggggaggg accgagagac gcgccgactt      540

tttagaggga gggatcgggt ggacaactgg tcccgcggcg ctcgcagagc cggaaagaag      600

tgctgtaagg gacgctcggg ggacgctgtt cctgaggtgt cgccgcctcc ctgtcctcgc      660

cctccgcggt gggggagaaa cccaggagcg aagcccagag cccgcggcgc ggccggcgga      720

cgaacgagcg cgcagcagcc ggtgcgcggc cgcggcgagg gcgggggaag aaaaacaccc      780

tgtttcctct ccggccccca ccgcggatca tgtaccagga ttatcccggg aactttgaca      840

cctcgtcccg gggcagcagc ggctctcctg cgcacgccga gtcctactcc agcggcggcg      900

gcggccagca gaaattccgg gtagatatgc ctggctcagg cagtgcattc atccccacca      960

tcaacgccat cacgaccagc caggacctgc agtggatggt gcagcccaca gtgatcacct     1020

ccatgtccaa cccataccct cgctcgcacc cctacagccc cctgccgggc ctggcctctg     1080

tccctggaca catggccctc ccaagacctg gcgtgatcaa gaccattggc accaccgtgg     1140

gccgcaggag gagagatgag cagctgtctc ctgaagagga ggagaagcgt cgcatccggc     1200

gggagaggaa caagctggct gcagccaagt gccggaaccg acgccgggag ctgacagaga     1260

agctgcaggc ggagacagag gagctggagg aggagaagtc aggcctgcag aaggagattg     1320

ctgagctgca gaaggagaag gagaagctgg agttcatgtt ggtggctcac ggcccagtgt     1380

gcaagattag ccccgaggag cgccgatcgc ccccagcccc tgggctgcag cccatgcgca     1440

gtgggggtgg ctcggtgggc gctgtagtgg tgaaacagga gcccctggaa gaggacagcc     1500

cctcgtcctc gtcggcgggg ctggacaagg cccagcgctc tgtcatcaag cccatcagca     1560

ttgctggggg cttctacggt gaggagcccc tgcacacccc catcgtggtg acctccacac     1620

ctgctgtcac tccgggcacc tcgaacctcg tcttcaccta tcctagcgtc ctggagcagg     1680

agtcacccgc atctccctcc gaatcctgct ccaaggctca ccgcagaagc agtagcagcg     1740

gggaccaatc atcagactcc ttgaactccc ccactctgct ggctctgtaa cccagtgcac     1800

ctccctcccc agctccggag ggggtcctcc tcgctcctcc ttcccaggga ccagcacctt     1860

caagcgctcc agggccgtga gggcaagagg gggacctgcc accagggagc ttcctggctc     1920

tgggggaccc aggtgggact tagcagtgag tattggaaga cttgggttga tctcttagaa     1980

gccatgggac ctcctccctc attcatcttg caagcaaatc ccatttcttg aaaagccttg     2040

gagaactcgg tttggtagac ttggacatct ctctggcttc tgaagagcct gaagctggcc     2100

tggaccattc ctgtcccttt gttaccatac tgtctctgga gtgatggtgt ccttccctgc     2160

cccaccacgc atgctcagtg ccttttggtt tcaccttccc tcgacttgac cctttcctcc     2220

cccagcgtca gtttcactcc ctcttggttt ttatcaaatt tgccatgaca tttcatctgg     2280

gtggtctgaa tattaaagct cttcatttct ggagatgggg cagcaggtgg ctcttctgct     2340

ggggctgact tgtccagaag gggacaaagt gcaatacaga gccttcccta ccctgacgcc     2400

tcccagtcat catctccaga actcccagcg gggctccctg agctctcaag gagatgctgc     2460

catcactggg aggctcagag gacccttcct gcccaccttc ggagacggct tctggaggaa     2520

cggcttggcc agaagacagg gtgtgagtga gacagtgggg cacaggttgg gtttgccaaa     2580

cgcctaatta ccaggccagg aagcatgcca acaaagccac acgggtgtcc tagccagctt     2640

cccttcacct ggtgtcttga gtagggcgtc tcctgtaatt actgccttgc cattctgccc     2700

ctggaccctt ctctccggac cagggaggcg tccctcccta ggagccacac attatactcc     2760

aagtccctgc cgggctccgc ctttccccca ccctggctct cagggtgacg ccacccacag     2820

agatttaatg agcgtgggcc tggaccttcc ccagatgctg ccaggcagcc cctccccaag     2880

cctcaaagaa gcatttgctg aggatggaga ggcaggggag ggaggcggga ggccgtcact     2940

ggagtggcgt ctgcagcagc tgctgcccca gcacccgctc agcctgtcct ggctgctcac     3000

ctccccgcag ggcaccgggc ctttcctgcc ctctgtggtc atctgccacc tgctggatca     3060

agtgctttct cttttacact cccctgtccc caccccagtg cactcttctg gcccaggcag     3120

caagcaagct gtgaacagct ggcctgagct gtcgctgtgg cttgtggctc atgcgccatt     3180

cctggttgtc tgttgaatct ttctggctgc tggaattgga gataggatgt tttgcttccc     3240

actgcaggag agctgccccc tttcacgggg ttggggaagg gtccccctgg cctccagcag     3300

gagcacagct cagcagggtc cctgctgccc acccctctga gccttttctc cccagggtat     3360

ggctcctgct gagtttcttg tccagcaggg ccttgacagg aatccaggga gtagctcctg     3420

gccagaacca gcctctgcgg ggcttgtgct ctgcaaagac tctgctgctg gggattcagc     3480

tctagaggtc acagtatcct cgtttgaaag ataattaaga tcccccgtgg agaaagcagt     3540

gacacattca cacagctgtt ccctcgcatg ttatttcatg aacatgacct gttttcgtgc     3600

actagacaca cagagtggaa cagccgtatg cttaaagtac atgggccagt gggactggaa     3660

gtgacctgta caagtgatgc agaaaggagg gtttcaaaga aaaaggattt tgtttaaaat     3720

actttaaaaa tgttatttcc tgcatccctt ggctgtgatg cccctctccc gatttcccag     3780

gggctctggg agggaccctt ctaagaagat tgggcagttg ggtttctggc ttgagatgaa     3840

tccaagcagc agaatgagcc aggagtagca ggagatgggc aaagaaaact ggggtgcact     3900

cagctctcac aggggtaatc atctcaagtg gtatttgtag ccaagtggga gctattttct     3960

tttttgtgca tatagatatt tcttaaatga aaaaaaaaaa aaaaaaaaaa aaaaa          4015


<210>  39
<211>  2018
<212>  DNA
<213>  Homo sapiens

<400>  39
gtgctgcggc gagctccgtc caaaagaaaa tggggtttgg tgtaaatctg ggggtgtaat       60

gttatcatat atcactctac ctcgtaaaac cgacactgaa agctgccgga caacaaatca      120

caggtcaaaa ttatgagttc ttcgtattat gtgaacgcgc tttttagcaa atatacggcg      180

ggggcttctc tgttccaaaa tgccgagccg acttcttgct cctttgctcc caactcacag      240

agaagcggct acggggcggg cgccggcgcc ttcgcctcga ccgttccggg cttatacaat      300

gtcaacagcc ccctttatca gagccccttt gcgtccggct acggcctggg cgccgacgcc      360

tacggcaacc tgccctgcgc ctcctacgac caaaacatcc ccgggctctg cagtgacctc      420

gccaaaggcg cctgcgacaa gacggacgag ggcgcgctgc atggcgcggc tgaggccaat      480

ttccgcatct acccctggat gcggtcttca ggacctgaca ggaagcgggg ccgccagacc      540

tacacgcgct accagacgct ggagctggag aaggagttcc acttcaaccg ctacctgacg      600

cggcgccgcc gcattgaaat cgcccacgcg ctctgcctca ccgagcgcca gattaagatc      660

tggttccaga accgccgcat gaagtggaag aaagagcata aggacgaagg tccgactgcc      720

gccgcagctc ccgagggcgc cgtgccctct gccgccgcca ctgctgccgc ggacaaggcc      780

gacgaggagg acgatgatga agaagaggaa gacgaggagg aatgaggggc cgatccgggg      840

ccctctctgc accggacagt cggaaaagcg tctttaagag actcactggt tttacttaca      900

aaaatgggaa aaataaaaga aaatgtaaaa aacaaaaaca aaaacaaaaa agcaacccag      960

tccccaacct gcactctacc cacccccatc acctactcca gctcccaact tttgtggact     1020

gagcggccgc agagactggg tcgccttgga ttccctctgc ctccgaggac cccaaaagac     1080

acccccaacc ccaggccagc cggccctgct ctggcgcgtc caaaatacta cctagcacag     1140

gcctctgctc gaggcacccc caaactacct atgtatccag ccccagaggg cctccattcc     1200

caggaagtcc ctatgtatcc caacactggc agacacccag caccaccctc ccagacccgc     1260

aagaaagtga atctcactac tacctactcc cctaaaacta cctattttgt gctggctggc     1320

ttgcctgcta cctagtgccg actgctccca ggcaagtccc ctgctgctta cagcccgcag     1380

cttttggggt ccctgaggct gccctgagaa tgtgctgagg tccaggatca gggtattggc     1440

atctatttaa atcgaaaaat aatatattta ttccaaaaag catcctaagt gcttgcaccc     1500

tagaatcaat ccctccttct ctggcttggc acccacagct caggcccatc aacccccact     1560

tctggagggg aatgttcctg agctggctgc agatctgtgg gttagcttct gcttagcagg     1620

actgtggaga tgcttccagc ttcgctgtcc tttcctctgg ctcctgtatc ttactgttca     1680

gctgtgttaa atatgtacgc cctgatgttt cctataatag cagatactgt atatttgaac     1740

aagatttttt tttatcattt ctatagtctt ggagttcatt tgtaaggcag tgtcttgact     1800

tggaaaggat gtgttaatgg ggtgactttg tagcatggta tgttgtcttg agttaactgt     1860

agtgggtggg gaggtccaat gccctccgca atgcccttca tctcctgtgt tgtcctgtac     1920

cctgctcagc tccatcctgg ggttcaggga aggcacactt cccagcccag ctgtgtttta     1980

tgtaaccgaa aataaagatg cgtggtgaca aagaaaaa                             2018


<210>  40
<211>  1728
<212>  DNA
<213>  Homo sapiens

<400>  40
agagggcgag ggcgagggca gagggcgctg gcggcagcgg ccgcggaaga tgagcagcag       60

ctgctcaggg ctgagcaggg tcctggtggc cgtggctaca gccctggtgt ctgcctcctc      120

cccctgcccc caggcctggg gccccccagg ggtccagtat gggcagccag gcaggtccgt      180

gaagctgtgt tgtcctggag tgactgccgg ggacccagtg tcctggtttc gggatgggga      240

gccaaagctg ctccagggac ctgactctgg gctagggcat gaactggtcc tggcccaggc      300

agacagcact gatgagggca cctacatctg ccagaccctg gatggtgcac ttgggggcac      360

agtgaccctg cagctgggct accctccagc ccgccctgtt gtctcctgcc aagcagccga      420

ctatgagaac ttctcttgca cttggagtcc cagccagatc agcggtttac ccacccgcta      480

cctcacctcc tacaggaaga agacagtcct aggagctgat agccagagga ggagtccatc      540

cacagggccc tggccatgcc cacaggatcc cctaggggct gcccgctgtg ttgtccacgg      600

ggctgagttc tggagccagt accggattaa tgtgactgag gtgaacccac tgggtgccag      660

cacacgcctg ctggatgtga gcttgcagag catcttgcgc cctgacccac cccagggcct      720

gcgggtagag tcagtaccag gttacccccg acgcctgcga gccagctgga cataccctgc      780

ctcctggccg tgccagcccc acttcctgct caagttccgt ttgcagtacc gtccggcgca      840

gcatccagcc tggtccacgg tggagccagc tggactggag gaggtgatca cagatgctgt      900

ggctgggctg ccccatgctg tacgagtcag tgcccgggac tttctagatg ctggcacctg      960

gagcacctgg agcccggagg cctggggaac tccgagcact gggaccatac caaaggagat     1020

accagcatgg ggccagctac acacgcagcc agaggtggag cctcaggtgg acagccctgc     1080

tcctccaagg ccctccctcc aaccacaccc tcggctactt gatcacaggg actctgtgga     1140

gcaggtagct gtgctggcgt ctttgggaat cctttctttc ctgggactgg tggctggggc     1200

cctggcactg gggctctggc tgaggctgag acggggtggg aaggatggat ccccaaagcc     1260

tgggttcttg gcctcagtga ttccagtgga caggcgtcca ggagctccaa acctgtagag     1320

gacccaggag ggcttcggca gattccacct ataattctgt cttgctggtg tggatagaaa     1380

ccaggcagga cagtagatcc ctatggttgg atctcagctg gaagttctgt ttggagccca     1440

tttctgtgag accctgtatt tcaaatttgc agctgaaagg tgcttgtacc tctgatttca     1500

ccccagagtt ggagttctgc tcaaggaacg tgtgtaatgt gtacatctgt gtccatgtgt     1560

gaccatgtgt ctgtgaggca gggaacatgt attctctgca tgcatgtatg taggtgcctg     1620

gggagtgtgt gtgggtcctt ggctcttggc ctttcccctt gcaggggttg tgcaggtgtg     1680

aataaagaga ataaggaagt tcttggagat tatactcaga aaaaaaaa                  1728


<210>  41
<211>  9178
<212>  DNA
<213>  Homo sapiens

<400>  41
aaagatggcc ggagcggcgg cggcggtggc cgcgggagca gcagctggag ccgccgcggc       60

agccgtgtcg gtggcggctc ccggccgggc ctcggcgcct ccgccgcccc cgcccgtgta      120

ctgtgtgtgc cggcagccgt acgacgtgaa ccgcttcatg atcgagtgcg atatctgcaa      180

ggactggttc cacggcagct gtgttggagt agaagaacat catgctgttg acattgacct      240

gtatcactgt cccaactgtg cagttttaca tggttcctcc ttgatgaaaa aaaggaggaa      300

ctggcacaga catgactaca cagaaattga tgatggttcc aaaccagtgc aagctggaac      360

tagaactttc attaaggaat tacgctctcg agtcttccca agtgccgatg aaataattat      420

aaagatgcat ggcagccagc tgacacaaag atatctggag aaacatggat ttgatgtccc      480

tattatggtc ccaaaattag atgatctagg actcaggctc ccttcaccta cattttctgt      540

gatggatgtg gaacgttatg taggtggtga caaagtgata gatgtcattg atgtggcgag      600

gcaggcagac agcaaaatga cacttcacaa ttatgttaaa tacttcatga atcctaacag      660

accaaaagtg ttaaatgtga tcagccttga attttcagat acaaagatgt ctgaattggt      720

ggaggtccct gatatagcca aaaaactttc ctgggtggaa aattattggc cagatgattc      780

agtctttccc aagccatttg ttcagaaata ttgcttaatg ggagttcaag acagctatac      840

agatttccac attgacttcg gtggaacttc agtctggtac catgtcctct ggggtgagaa      900

gattttttat ttaataaagc caacagatga aaatttggca cgttatgaat cttggagttc      960

atctgtgacc cagagtgagg tgttctttgg agataaggtg gataaatgct acaaatgtgt     1020

ggtaaagcag ggacatacct tatttgttcc tacagggtgg atccatgctg tgctcacttc     1080

tcaggactgt atggcttttg gggggaactt cctgcacaac cttaacattg gcatgcagct     1140

caggtgttat gagatggaga aaaggctaaa aacaccagat cttttcaaat tccctttctt     1200

tgaagccata tgttggtttg tagccaaaaa cttgctggaa accctgaaag aactgagaga     1260

agatggtttc cagcctcaaa cttacctagt acagggagtg aaagcactgc atactgcttt     1320

aaaattatgg atgaaaaaag aacttgtatc tgaacatgcc tttgaaattc cagacaatgt     1380

tagacctgga caccttatta aagaactttc taaagtaatt cgagcaatag aggaggaaaa     1440

cggcaaacca gttaaatctc agggaattcc tattgtgtgt ccagtttcac gatcctcaaa     1500

tgaagcaact tccccatacc attcccgaag aaagatgagg aaacttcgag atcataatgt     1560

ccgaactcct tctaacctag acatcctaga gctccacaca agggaggtcc tcaaaagatt     1620

agagatgtgt ccatgggaag aggacatctt gagctctaaa ctgaatggaa aattcaacaa     1680

acatctccaa ccatcctcca cagtacctga atggagagcg aaagataatg atctacgatt     1740

actgctgaca aatggaagaa taattaaaga tgaaaggcag ccctttgcag atcaaagtct     1800

ttatacagca gatagtgaaa atgaagagga taaaagaagg acaaaaaagg caaaaatgaa     1860

gatagaagag agttcaggag tagagggagt ggaacatgaa gaatctcaaa aaccactgaa     1920

tgggtttttt acacgtgtga aatcagaact caggagtaga tcatcaggat attctgatat     1980

ttctgagtca gaagactccg gacccgagtg cactgcactg aaaagtatct ttaccactga     2040

agagtctgaa agttcaggtg atgaaaagaa acaagaaata acatccaact ttaaggagga     2100

atctaatgtg atgaggaact tccttcaaaa gagccagaag ccatctagaa gtgaaattcc     2160

aattaaaagg gaatgtccta cctcgacgag cacagaggaa gaagctattc agggcatgct     2220

gtctatggca gggttgcact attccacgtg tttacaaagg caaatacaaa gcacagactg     2280

cagtggtgaa agaaactctc tccaggatcc cagcagctgc catggcagta accatgaggt     2340

taggcagttg tatcgctatg ataaaccagt ggaatgtgga taccatgtca agactgaaga     2400

tccagacttg aggacttcct cctggattaa acagtttgat acttccagat ttcatcctca     2460

ggatctaagt agaagccaga aatgcatcag aaaggaaggt tcatcagaaa ttagtcagag     2520

ggtacaaagt aggaattatg tggacagcag cggctcaagc cttcagaatg gaaagtatat     2580

gcagaattca aacctgactt cgggggcgtg ccagataagt aatggcagtc taagcccaga     2640

aaggccagtt ggtgaaactt ccttctcggt gccccttcac cccaccaaga gaccggcatc     2700

aaatccacca cctatcagca accaggcaac aaaaggtaaa cgtccaaaaa aaggaatggc     2760

aacagccaaa caacgtcttg ggaagatcct taagttgaac agaaatggcc atgcacgttt     2820

ctttgtgtga cagagctgct gttgcagcca ttcttccctt tggagaccag tctaggggtg     2880

caggagcctg gagcttccgc tgtccccctg cctggagcag tttgtgtgta tagtaagaac     2940

actgcccgaa gaacagaatg aacctgatgc tgcattttca ctgtgccaca cccactcagc     3000

aataaccatt ttggacctgg tgggggagag gaagaaggag ggtagaacct taaaaagaga     3060

ccttgaactg gaaagggtct cttgtcaggg cttgaatttt attttgttgt tggtagtgtc     3120

ttgatgtatt ttcagtggta gggtaaagaa ttatcaataa tttatttaac agattttttt     3180

ttaaagttaa cagcttttaa attctttttt taaagctatt tatttggaag atttctggag     3240

aaatatctca ctaatttaga tgtaagaatg tgaaggtttt taaattattt ttgatagtgt     3300

gtgtgttaca tgtggggaag ggccacagta acagtaacta gtctggactc ttaaatttga     3360

tattcaggtt aaagtcttaa acagggattt gatgcattaa ttattttaaa ttaagatgta     3420

tatgaaaatc attttatttt atatatttca tgtgtttttt ataagctatt agcttcgctt     3480

ttgctaacat ccaaggtgca tactgttatc caggttgatt accttatatc ccaccttccc     3540

tctgcactcc ccatcatttt gtgatgaccc agtaagactc ttctctttgc agggaaacac     3600

tttcgtagcc aatgtgtaag aactccatga aagatccctc atttctcatt tcgtttgaca     3660

ttgtgatttt cttctcaaca ttaaaaaaaa taggcttttg cattttcatt tctgctgatg     3720

atatctgggt cccaaagaga gcagctttaa tatatttttc ctacttgtgg gaaaagtatt     3780

ataagtttgg ttaaattgtc atgtttatag tttttccaag tacatttgta actacagcag     3840

gccttcttcg tactgctgct gttggacaac aggactggca cctgctgcag aggttatacc     3900

ttatgatact tttatgctcc atacctgatt tgttgggaaa tgttatttag gatattcaaa     3960

tctgcatcat aagccgtaat ataataggat taatactaca ttaagttgta tagaagcaag     4020

catgttggaa tagatctttt gtgtgtattt acttttttta tttcttaatt ttctaaagaa     4080

ttacttaaga tatggatttg gagtaaaatg ggtgcttttg gcagtttctt ccatctatcc     4140

taacctgacc agtacatatt gaggttaagt atctggttaa actttaaggt attcatttat     4200

ctcctttatg tatgattttt actaaatgcc agttttcatt tgcttatagt agcttctatt     4260

ttcccttttt tccatccatg gcataaaaat aagtgatttc tgggggtggg gcagaaatgt     4320

tcccaagtct gacaatagag cattttacaa attcctacaa agaaaatata ggcaaataga     4380

taaaatttat ttttatggag aagaaatatg gccatattat ggatttgtct tttttttact     4440

cagcaagata gcaggactta cccttctcta ttaagtatca cttgaattgc taagaagaaa     4500

aaagtctgta ccatcatctt tcatggttgc attcaaatgt atattttcaa agagaaatac     4560

ttcttgtgtc cccattccaa aatgtcatgg gataaatatg aaatagttta tgaagtagcc     4620

tttctggttc agagtgactg gaccaaagtc tgaatcttat ctgggtatca ggaaaaagaa     4680

tttttatgga aatccttagt gtctataaac aacccgtgta aaccctgtct acactatgcc     4740

aaaaccagtg gaaagatggg tagagtcatc ttatctcagg atgtcaaaaa tctgggtttg     4800

actgattccc ctaccttccc acacagtata ttcttgtgat ttttgctttt ctgtagatcc     4860

tgagtcggtg ttacaatagt catgttttta ttttgggtta agaaatacga ggtgtaagag     4920

ctataatttc cttttcgtgt tatatcatga tctgggtttt cttttttcct ttacgttttt     4980

cacagctctt gagtattttc tatttttttc tttagtcaca aaaattaaaa ttaaacttta     5040

tttttatgaa ttaaaatgaa atttaattta tttttatgaa ttaaaattgt ggccagtatc     5100

cactgtgtcc ttaggctgag aagtactaat ttggagtagc ccgtgtgtgg aattctaaag     5160

tgaaggtact gtggattcat ttttagtagt tttagcccct taataagtgg ctaagttaga     5220

aaactttcag cgaggtaata gaaccacttg aatagaatcc atgtgtcttt ttctgaattg     5280

gtgaaaattc ggccactgat ccagtgactc ctggtcaaac gtcttataac attactggcc     5340

ataatgcatc cctttatctc atggaaatgg ctgaactttg tggtagctgc tgcgagtacc     5400

tgggcttaac agtaatagag aacctcattt ataccataca gacacagcaa cttaggaaga     5460

cagcactgat agcatttagc tagttgtaac caaatacaaa tatgtaaaat tgagaattat     5520

gattaacata tgcaacttta gtaataggaa tagatgataa ttttcctgta ttgtttcaaa     5580

taagtgactg ttcagctggg atccattgga ttataattta caatgtcaca taatattatg     5640

cttttcaata ttgatgagtg atgtaaacaa tataaagttg gcagtttgta gtagttcagt     5700

atcctagaaa tacattgaac ttcataagta tcagttcatt tttaagcata cagaattgaa     5760

gattctgact gaaatcataa actcagagga aacaagccca tctttatcac taattactta     5820

gcttgaatac ttttctattt ttaaataatc ctaattattg ccttttcaat tatagtctac     5880

tgtatttatt tatatgggat caacaggtat ttatcaaaca tctactgtgt gcccagcact     5940

acctagtact gttggggaac atcaatttgc agttgtggtc tctgcccttg aaggtatctt     6000

ctccaggaaa ttagcagtat tattttcact tctaagcaaa catgagcaaa agaggacctg     6060

ttcattaaaa aacatgctga cttttttagt ttcaactgag atatgccact gtagaagtga     6120

aagtaatttc acaattaaag aaatgcttca acttggtaat taatatggtc atacagggac     6180

ttggtgtagc atgcaaggaa gcagaagacc tgggcttttg tcgaagttct gccatttagg     6240

tatcagctgt gtaaccttga ataagtcact taactctttc tcttagtttt ctcatttgta     6300

aatttggatt aaagtgttta ttatgataat caattaagaa aatctcttaa cacttcatac     6360

atacagagaa cttatcatta agttaaaact ggcaattaat gcacctttat atatattttt     6420

aaatgaaaac taatactatt catgatgttt attttatatc aaatatatgc ccagggcatg     6480

ctactttaaa aatccgagga atctccaaca aggtgctgga ttaaaatcag atttcgtgct     6540

tgaagtggaa gaaaaatgaa gttgtttatg gataagagag tgagaatgtg tatcctcaag     6600

tacgttaaga tgatttaact gaaagatggc tttaggtttt tcttgaagaa ttaggaaagt     6660

accatcccca cagattcagc atactcttca ggtactagat aaaggtgaag gaagtcatgg     6720

aattaaaatg acttagcaac tccccaggga acttgtgggg agaatgaggt ggttagaaag     6780

gtgagaatgc acaaagacag ctctgggttg ggtaccaaca gtttgcttgg tagaaagaaa     6840

ccagtgtagg aaaggagacg ccaccagaca tcttcaacag acaagattct ttctgccttt     6900

ttcaaaagat gctctctgca gcagtaagac tatagataga gttgattgga atatcatgtg     6960

acccagtatg ctactgctag gcataattat caaaaattca tttttctcat taaatattgt     7020

taattgctcg ccacataaag agaagctaga gctcaccagt cttggtggtg tcctagacct     7080

tcctctaaag cagtcttggg aagctggatc atcagatctt tagcctagac agagtgtcgc     7140

tggtaaataa aggagacaca ggtaacccag agtggacagt gatttgcgtg gggagacaca     7200

gtggatctgg ggcctctgat actttgcttc ctaaaacagc ccccagtttt cggcttgccc     7260

tatgagatga tgttcatgtg cttccttgaa accaggtgga aagaaagggg aagaattaat     7320

tttctcattc tgttgctgtt gaacgtaatg taatcttaat actgtagcct tcctagaagc     7380

ccttccctct ttttcatgct gtaaagtcaa atatttgata tccttaacat aaattttaaa     7440

aattaaggtc attaggaagc aaatgtctat ttccaaagca atgagcttgt tgtgactgtg     7500

attttattct tctatagtat ttttttcctc attttaactg agaggagaaa ataatactct     7560

tttgcaatat ccttaggttc tccccttccc cctggtgccc cttctagtgt cttaagactt     7620

tgtcttaaca agtataacat tacattttgt tgttaaaacc tttcgaaact gtattcagtg     7680

attcttccaa gtttatctgc tctgcactat ttcactaata aaccctggct accacgtagc     7740

ccttgatctc caagtagttt acctatgcaa gacctgtgac actctgaatt cacttctctt     7800

tctttcagaa agtagtcata aatggagctt aattataaag gtaaaacttg tctccaacca     7860

gtttcatttt ggccatttct ttttcaaaat gtcagctgtt ttcctccaag atttttcacc     7920

aaaacaatga tcataagtgc tggaatatat aatactttgc aggcataaaa taacccagac     7980

atactctcat atttctttgg tgtattttgg ttggtaaaac ttaccagcat taaatgtaaa     8040

atataatgag gagttaattc cttacctaga actatttctt ccttttaaga ttcataagta     8100

accttttatt tttacagagc tacgtataac ttccacatta cagtcaggga cctgaggtgt     8160

aacttactaa gtgaacccca aggttatttt atcttgcaaa agaaacctaa accaaactaa     8220

gggccttaca gtttatggtt agactgaatc aaaagctata acctcaattt ttccaaaaac     8280

agcttctgac tgcaaaagca agtcatacag ttgttaggta tgaaatagca ctgatcagga     8340

aatgcatctt cgcagatggt atttccttca gaaaagactt ttctactttt aatataaatt     8400

aagccataac agtttcatgc tgtggaaaga gggtgaaaag gttcatttta agagattata     8460

taatatgaac tttcacattt actgtgaaat gtctaacttt gccagtgctt cagcaagttt     8520

ttttgggggg tgatggggag gggtagtatt ggttttagag gtttcaaatc tgtgaacttt     8580

ggagagggga cagttgttgg ctctggtatt tactagtttt gtagtaacgt tttgctagcc     8640

tgactgactt ttcttactgg tttttatgcc cacggtccga ggggactgtt cttcttgttg     8700

ggggtgtctg cggaatagcg tctcgtcttg tttgtatagg cagtcaatgt gtgtgacatg     8760

tgtgtccttt cagtccggaa gcccactgtg tgacaatggc gtggggtgtg gctgggaggt     8820

ggggtgctga agcttgaaga gcatttcttt gctgattcat aacagtattt cccatctttt     8880

gcctgcaggc agggaaagtg tacagtattt attttgtttc tgttttactt taaatttgta     8940

agtctttaag tagcttacat tgattattat aggggaggac aagtgacttg tttaaagttg     9000

tatttagtat tctttccaat ttctgtattt taaaatattg aaattaaaat tgtattactt     9060

ctgttttgat ttttttagca cttagtgtat tttttgctca ttttgtttga aagtataaat     9120

gttgaaaatt gtataaaatg cgtccttgaa agaaaaagaa tctgaattct atatccaa       9178


<210>  42
<211>  8433
<212>  DNA
<213>  Homo sapiens

<400>  42
agagaagcga tcgcgagaga aaaaaatgca acctcccaaa ataaagagca aagattgcat       60

taggagcgaa cagcgctgca gaaatagatg gcagcttcgt gtcagtgagt ttgcatcccc      120

cttcctgatc cacgagctgg agtgattaga gccctggaag ggaattgtta ctcccgtgga      180

gaagtcccct tttcctggca gtcgtctgca ctgtacacgc tggatgcctc tctccatcca      240

ccccactcac tcgctcctct ctcacctcct ctctccctct cctgcattga tttttttttt      300

tcctttttag ttgactgaaa caaaacaaaa caaaagggcc actggatgtc tgccttcttg      360

gggggtgagc cagacagact gacaaacaaa cagccccaac tgtgttcggg ggagggtttc      420

gcctcccgtt ttgcccggca gcagcagcat ggacgtgttg gctagttata gtatattcca      480

ggagctacaa cttgtccacg acaccggcta cttctcagct ttaccatccc tggaggagac      540

ctggcagcag acatgccttg aattggaacg ctacctacag acggagcccc ggaggatctc      600

agagaccttt ggtgaggact tggactgttt cctccacgct tcccctcccc cgtgcattga      660

ggaaagcttc cgtcgcttag accccctgct gctccccgtg gaagcggcca tctgtgagaa      720

gagctcggca gtggacatct tgctctctcg ggacaagttg ctatctgaga cctgcctcag      780

cctccagccg gccagctctt ctctagacag ctacacagcc gtcaaccagg cccagctcaa      840

cgcagtgacc tcattaacgc ccccatcgtc ccctgagctc agccgccatc tggtcaaaac      900

ctcacaaact ctctctgccg tggatggcac ggtgacgttg aaactggtgg ccaagaaggc      960

tgctctcagc tccgtaaagg tgggaggggt cgcaacagct gcagcagccg tgacggctgc     1020

gggggccgtt aagagtggac agagcgacag tgaccaagga gggctagggg ctgaagcatg     1080

tcccgaaaac aagaagaggg ttcaccgctg tcagtttaac gggtgccgga aagtttatac     1140

aaaaagctcc cacttaaagg cccaccagag gactcacaca ggtgagaagc cttataagtg     1200

ctcatgggag ggatgtgagt ggcgttttgc acgaagcgat gagctcacga ggcactacag     1260

gaaacacaca ggtgcaaagc ccttcaaatg caaccactgc gacaggtgtt tttccaggtc     1320

tgaccatctt gccctccaca tgaagagaca tatctaaaaa accgaaaggc cagagttgcc     1380

atggcatcgg ctagtgtcta aaggaaacgc catgaggcag ggggctggac ttcaggcggg     1440

gacccattgc ctcgcagaag aaagttctca cttataaacc tctgtacaca cacacacaca     1500

cacacacata tacacacact cacagaccca cacacataca cactgtcatg cactcaacta     1560

tatttaaaat atatacgtct attctttatg ccttgcccta gccagatgga agaagatgaa     1620

gaaggaaacc aggtgaactc agcaaggcag actggctgct tacttcagca ctattggaat     1680

tatttcccgc tgttgccaat ggaaatcaaa gaaaatggat gtgacgtctg tgcaggtgga     1740

cggcagtccg aggggcttat ttcacttgct tctcagtgca acttgatagg agaatccagc     1800

atcttaaagt tgcatatgtg tagcactaat gtttcttttt aaatagttgg gggaaaatga     1860

cctagaaaac caaattgcag tttggtagcc aaaattaact cttggtttat ttgtcctttg     1920

tgtgtgaaaa gtcctactat tccgtgcgtc agacttcctc acagaactgt tgactggttt     1980

tggttcttag tactattgag atctttcgcg tcgatcccaa cggccttagc ggcggcagac     2040

tggaataaca ccttacacct ttctggcctg catttctgta gacttcactc tcaagggagg     2100

agttttcttt tcttacgttt tgacttttgc acaccatatg cactagggat tctggaaact     2160

tctagcatga ctgcaaagtg gccaagagaa taaagtcctt gatgataaat cacagtatat     2220

cccttgagcc tcaccttatt gccagtgcta gattttttct ttttaatctc tccgtttttg     2280

ctaacgaaaa cttgaaaagc ttatttggaa gcttaaatgt tttatctttt ctccatggac     2340

taaacctctc caggactctc tcggcacctg gatgtccagc tctcgaagca gccagtcaga     2400

tgggacatca cagttctctc atcctccttg aggcatgatg acctcagctc atagtgatca     2460

accgttgtgc tgtgtgtcat tgctacccca taaccagtta cagcatagat gtcgctagtc     2520

tcagagggca gctgcgtatt taatttaact ctggtttatg acctgacaaa aagccaaaaa     2580

tatcactctt tccaggagtg gggaaaactg aggatgcctc ccaagtctag tggcttcaca     2640

aaagatcatc ctgtcttctc tgtcatgccc actgagctcc tattccccta cgtgttacaa     2700

tacacaattt aaaacgccat tgtgggagtg aagggttgac atttaaggaa aaggttgagg     2760

tgtttctctc atgggctgtc taaaaggaga gacacgtttc tttctttcct tttttttttg     2820

gctaggccca ccatgacttg tgacctagaa cccccaggat taacagaggc ctcacattta     2880

ctctgcaagc tgactccaaa ggagtctaca gtccttactt gtcatgccac actcacacat     2940

ccagtagtgg tctctatcta cccgcattcc tagctagctg gcactggcct caactccaaa     3000

gactgccttt aggaccatca aatggcctat gcaagcaagc ggggtggtta ttaggacaga     3060

ttgtatattt tgtatattct gggaccatcc cttcaagaca cgtctataaa acaaaaatgg     3120

cgcttggtcc acacacggtt gctgctccct cctaccagct ggctcccctc ctgtcctcct     3180

ttgactgttt gactcattga ctgttaaaat gccaccccat acatatttgg gatgcaaaac     3240

tgaagtcaaa aggaaataat ataagaaaca caaacacata tatgacagca accttcaaga     3300

tctgggtttt cagctttctg caacctttgt tttcactgaa atgttgaaac tactcgtctg     3360

agggcaaagg aacctcctca caaatgctat agctgccaat tggacacttg gggcatttcg     3420

aggtctggcc ctaagaattt actttctcct tttccttttt tctatttaga ccaaaaaaaa     3480

caaaaacaaa aacaaaaaaa aaaacaaaat aatacaaaac gaaaaaaaaa gaaagaacac     3540

ccgttaacac acacgcgcac acacacacaa aatctgtcca tttgccggag gcaattgtat     3600

gtatgttagt tggagggtat taaaaatcag ttttattcca aagatttaaa actagacatg     3660

acttaaaaac aatttctgga gcactgcttg ctgacaatct cgtagttctc tgctgcattt     3720

gagtgcattt tgtggccagt ccatcagggc gtaccatggg attatatttg aatgtgtggt     3780

gcatccttcc tggatgaagg atgtgtgagg gaccttgaac ctcagctgta ttaaactgta     3840

gcgcctccag tcagtgcact agatgaaact tttagacacc ctgaattctg ttggttcctt     3900

tcttttcctt tatgtagcag cctccagcat gaatgcacgc acacgccagt gatggcatta     3960

agccatggcc accacgattt gcaaatgttc tctcccaagc tggagctgct cttgcctctc     4020

gaatgctatt attaagggtt tataatactt aatttaattt tcgaactgac caatgcaagg     4080

ctctattaaa aagaaagttt aaaaaatgca aaagagtaat cattgcttgt ttgctcccta     4140

ttttcatctg tggtctcatt tgaatgtggc agaacaaagg ccctttggtc ctcatcagtg     4200

tctgaaatgt tcagtaattt ctctctcttt tgtatcagtg aggtcctttg taatctgctc     4260

ctgacctttc ttggagcagg gtgcattgaa actcaatggt ggtgcttgct tgcttcagag     4320

tcatttgttg actgtgagaa ttggcctaag aatttggtgg gtgctaagtg gatggctttg     4380

aaactgttct tctttagccg agttgacacc tgtgaatgat gaccagtcct gatcattttg     4440

gaaatggatt tgtaataaaa cgtccatcac ctctgcagtg gcagagatgg ttactaagag     4500

ccgctagagc gagcaggttt tccaagaagt aacctgaaga cattttgctc ccaagaggac     4560

tggttattta aaacagtgca ttaatggaca tttgaaacac attaaacccc tttctcattt     4620

cagttgttac ctcctaaccc tccaggggat cccaaatttg aaaggaaaaa cccggcctgg     4680

tgtttctggt ggtgtcctaa caagcacgct tttatccagg gttcagattt gttcatgtag     4740

aaaaagagtt tctaagccac tgacaatttt ttttttttgt aatttcaaat tatacttctt     4800

tctcctgcca catgactgta agtcatagac atggaaacct gaaattataa tgctgctcct     4860

agctactggc ctcctgcccc acccatggtt aatggctcag ctcaatgcct ggtggtaatg     4920

agtattatgt ccagaaaaag agatgttcag attccatgac aaagctgcat ttttgtaaaa     4980

atattggaga ccccaaaatg aacttcatgc tgaccatttc ctcctctctg tgtgctttcc     5040

cttgcaaagc ccttcaaata tcctcttctc tcgacgccat ctcctctcca cctgcacctc     5100

ttgtgccctt tgtacatctt tgattgcctg atgataacag ggtaaaagga cagccaacct     5160

catgcctgat tagcagaact gaatcctagt tttaaaaaat cttctctggc ttcagagaag     5220

attttataag gacttttgtt tgggataagc tttccagatt atccatgtct atttgcatca     5280

aaggggaaag aaatggggct tttggatggc tcttccagtg cattcggaac attgcctctt     5340

gcctttattc ctgcatttta tggcaaagcc aaaagaaact caagttgcaa gaacaaaacc     5400

cagtgactcg ttttgatggt tcaaaatggt ttcctttatg gaagtcactt cataaaatgt     5460

taagtaaaaa gtgggaagtg cttctgtctt ctcttttgca tgagttgctt ttaggagcag     5520

gaagaaggta ggcaaagtaa gataaagatg caacacattt aactacaaaa atcaggttca     5580

ttttttagtt tattagaatt tttttgaaat cttaagaggg ccagcatttc tggctacaat     5640

tttgcaccca gaacattgcc aaaatgaaca ttcagtaaat agaacctgat tgaaatttac     5700

tcctggaagc tttcctttgc attttcggga agtggccacc tgccaagcgc aagagttggg     5760

gggcaggagg ggaggactca aattcagggt gtctggatta aatttcggtg aacatggtga     5820

tatctcagtt tgaaaactag agggcctatc ctgagtatac atcaatgtct ctttgatggc     5880

ctactttcct cagtgaggat ctttgggaat acttgagatg gaacaacaga aatgtgtgaa     5940

aggaagcaga aacttcttgt aaataacgtg acctcccacg acgaactgcc tgaggcttca     6000

gggttttttc ttgcttttaa cactcttaaa tctcctctgt tggttcctaa tagatcccag     6060

aaaagggaaa aataaagctg cagttaactt tcttatgtgc atccttccaa tagagtactg     6120

tatttttcag gtgttttgca tttaacataa aagtcctcgg gaaacaggtg tcaaaaacag     6180

agagagaaat cctgggccat cacttcacaa atatcccaaa caagatattc ttttcaaaca     6240

gggctccctc tcagtggtca tgagggaagg ttgataatgt tctttgttgg ggactgttta     6300

tacaattttt tttcaactgt gagctttgga atcgtaactt gctgtgagtc cagcttctgt     6360

ctactgccat aagatggacc ccacgtcagc ataatgaggg tggtatatat gctcgcacct     6420

agacatgcgc atatgtacct gtcgtacctt cacggaagga aaacaggcta ctgacgtttc     6480

ggaggagtag ccaccagtgc ctaatatctt ttggggggga tggatgctta taattgccag     6540

tatatcgaaa ccacactggg agttccacat agcggggagg ggttgggggt gggcagaggg     6600

gacattttaa acctaggcct ttggactgga ggcagaacga tttctgcaaa cctaggtcct     6660

gaaggctttg gggcttattg gctggttctc aacctttttg ttttttcttc ccagcatgca     6720

tttcctatct aaacccagac ttagtttaat ttccttatct ttcacttctg cttcattcca     6780

gggaggaaaa atacacctgt taatggccaa gatctccttg ctaacacaga ggcaaaaata     6840

aatgtctaat gtttttgaag cctccccttc ctttccacaa gcccccaccc gcccccgcgt     6900

caagctcctt ctcccacttc ctactcccac acaacttccc agccactgaa acttttcttt     6960

caaatctcta ttatcctctt aacagttgct tgaataaatt tatttttgca ctatacattt     7020

tctttttgcc agatgtgtct aacaagtgtg tttggagaga cctactccca gccccgtctc     7080

cttccccgcc tccccccgtc acattctctc aggccttctc tggtatttat aatatatcac     7140

agaagtaccc agtcttatag ccctcggtta tgcctttttt tgacatttta ttttttttaa     7200

gctttttata tatatatata tataaatata ttactttgtc aagttttttt gctgtacaaa     7260

agtcttaaga tttaaaacta ttatttgtat tatatgatgg tggtatgtta atgttacaaa     7320

attattaatg aagaaaaaat ttatttttgt tactggtctg tttcataatt cttttttaaa     7380

ttggtatatt gtaagatatc tatgcaaaaa atgttatgtg acgcattttt atttaagaat     7440

gtaatatgtg taataaacag tagaatgtgt ttggccttgg aatactttac tgtatttctc     7500

cttagcttgt ttcactgggg aaaaaaatct tcgaaagacg caagtgggta cttacatact     7560

tcgtgaaagt tttctttctt ggagaaaggg aaagcaaaag gttgtattag gttatcttcg     7620

tttgggaagt tgtgtgtgtg tgtgcgtatg tgtgtatttt atagtttcat tgaggcagct     7680

caatgcccaa ataagggtca ctgagtttat ttcttcaagg ggaaaaaggg agccaattgt     7740

tggagattat gaaaagcaat attttagaat gatagagatt acaagatgtt atttgtttag     7800

ggggttggga gaggcttatt gaaagcggtt tatttggcga gagaaggagg cagtttgttc     7860

tgggatggtg tttaatagga acctattggg aaaggatctt tgaagcagtc tgtgaaggag     7920

gaagggtaaa gatcagaggg aataatttag gtgaggggta gggggcagta aaatgacagg     7980

aggtggttgg agtggggagg aaatgggtaa ccggaagcca ggaaatccag ctggctgtgg     8040

agagtacaaa aaactagatg gaaatacaag cagcttcaga cccagagaag agagggagat     8100

gaaagcccca gggaaaattc tcagaactga aaagaaaagt actaaaatct ctgccacaca     8160

cgacttccag gaaagagcat caccagtaag gaggaaggta gagaacccag ctggtggtgt     8220

cgcctcagca tcccgagctc agcgattccc cgagagaagt ggtgtcattc acaggaaaca     8280

gcagtaaaac acatttgtca catgggacac agcagtagtc aagctttctt tgcattcttt     8340

ggacttacag aagtggatac ggtggtgaat aacctctatc cctaatcaaa tgaatctgac     8400

aagaaacttt ccaataaatg tttactttag aaa                                  8433


<210>  43
<211>  5208
<212>  DNA
<213>  Homo sapiens

<400>  43
cttactcatt tgtgtttatt cttggactta tcctgacata atggggtttt tttaattata       60

gattcacact gcatttattc atcacccctg tcctctcatc cataactcaa atttactacc      120

agcaacacaa aatacaaaga tgtgtccagt ttcactacag ctcttcgcgt ttacaagtgt      180

cgagcgcttg ctttcggaac gcccttgtga ttggccgagc caatgccagt gacatcaacc      240

aacttacttt tgattggaag gctggttgct gggactgtag cgtttgcagg aagtcactta      300

actgtttggg agctggaaaa ccgaagctga agttctcttt tgccatagga acgagcgcaa      360

ctgactagga aagatgtgtc ccaaagctcc gcaagctgga acgtgagcca ggaggcccgg      420

accggccacg ggaccgcgag gcactccgaa agtgtgcggc tgccccttcc ctgcctccca      480

gctgttaccc ttttaaatgt cagtgttcga ggctgtaggg gtagcacgag gcagcgaaac      540

ggaacagtcg gattggccgc acgcctcagt tctagacgca cctctccacc gaaggccgtt      600

ctgactggca gggggagaaa gtaaacagag ttgaatcacc ctccccactg gccaattgga      660

gggggtttgg tttgtgacgt gatgggattc tgcgaaattg ttactgagca agagaatgcc      720

ggaacggtgc ggaccggccg gagcaggggt tcagaagccg tcagtggact cgggaaaaag      780

tgtctcttag acctggcgct cggcgggacc ctcgccaccc gcgtcggggt gatcgggtga      840

atgtcctggg gctttggctc gacggcgagg cggccgaggg cgtgcacctc tcttgcagtt      900

tcctctccca gcgcctcggg ggcgttttca gtcgaataaa cttgcgaccg ccacgtgtgg      960

catctttcca agggagccgg ctcagagggg ccggcgcgcc cgtcggggga tcgcggccgg     1020

cgcggggcag gggcggcggc tagaggcggc ggcgcggcgg agcccggggc cgtggatgct     1080

gcgtgcggag gcgctgccgg ttacgtaaag atgaggggct gaggtcgcct cggcgctcct     1140

gcgagtcgga agcgccccgc gcccccgccc ccttggccgc cgcgccgtgc cgcgccgcgc     1200

cgcgctcgtc gtccgaggcc agggcagggc gagccgaacc tccgcagcca ccgccaagtt     1260

tgtccgcgcc gcctgggctg ccgtcgcccg caccatgtcc gcggccgcct acatggactt     1320

cgtggctgcc cagtgtctgg tttccatttc gaaccgcgct gcggtgccgg agcatggggt     1380

cgctccggac gccgagcggc tgcgactacc tgagcgcgag gtgaccaagg agcacggtga     1440

cccgggggac acctggaagg attactgcac actggtcacc atcgccaaga gcttgttgga     1500

cctgaacaag taccgaccca tccagacccc ctccgtgtgc agcgacagtc tggaaagtcc     1560

agatgaggat atgggatccg acagcgacgt gaccaccgaa tctgggtcga gtccttccca     1620

cagcccggag gagagacagg atcctggcag cgcgcccagc ccgctctccc tcctccatcc     1680

tggagtggct gcgaagggga aacacgcctc cgaaaagagg cacaagtgcc cctacagtgg     1740

ctgtgggaaa gtctatggaa aatcctccca tctcaaagcc cattacagag tgcatacagg     1800

tgaacggccc tttccctgca cgtggccaga ctgccttaaa aagttctccc gctcagacga     1860

gctgacccgc cactaccgga cccacactgg ggaaaagcag ttccgctgtc cgctgtgtga     1920

gaagcgcttc atgaggagtg accacctcac aaagcacgcc cggcggcaca ccgagttcca     1980

ccccagcatg atcaagcgat cgaaaaaggc gctggccaac gctttgtgag gtgctgcccg     2040

tggaagccag ggagggatgg accccgaaag gacaaaagta ctcccaggaa acagacgcgt     2100

gaaaactgag ccccagaaga ggcacacttg acggcacagg aagtcactgc tctttggtca     2160

atattctgat tttcctctcc ctgcattgtt tttaaaaagc acattgtagc ctaagatcaa     2220

agtcaacaac actcggtccc cttgaagagg caactctctg aacccgtctc tgactgttgg     2280

agggaaggca aatgcttttg ggttttttgg tttttgtttt tgtttttttt tctcctttta     2340

tttttttgcg ggggagggta gggagtgggt gggggggagg ggggtaaggc caagactggg     2400

gtagaatttt aaagattcaa cactggtgta catatgtccg ctgggtgagt tgacctgtgg     2460

cctcgcacag tgattctggg ccctttatgc ttgctgtctc tcagaattgt tttcttacct     2520

tttaatgtaa tgacgagtgt gcttcagttt gtttagcaaa accactctct tgaatcacgt     2580

taacttttga gattaaaaaa aaaaacgcca tagcacagct gtctttatgc aagcaagagc     2640

acatctactc cagcatgatc tgtcatctaa agacttgaaa acaaaaaaca gttacttata     2700

gtcaatgggt aagcagagtc tgaatttata ctaatcaaga caaacctttg aaaggttaca     2760

ctaagtacag aacttttaaa ccttgctttg tatgagttgt actttttgaa cataagctgc     2820

acttttattt tctaatgcag aggatgaata agttaaatac atgctttgag gatagaagca     2880

gatgttctgt ttggcaccac gttataatct gcttatttta caatatacac gtttccctaa     2940

gaaatcatgg cagagatgtg agggcagaat atacacaaca gatgctgaag gagaaggagg     3000

gtagtgtttt gcaaaagaaa aagaaaagaa ccaacagaat tttaactcta ttaacttttc     3060

caaattttcc tatgctttta gttaacatca ttattgtatc ctaatgccac taggggagag     3120

agcttttgac tctgttgggt tttatttgaa tgtgtgcata acagtaatga gatctggaaa     3180

cacctatttt ttggggaaaa aggtttgttg gtctccttcc tgtgttccta caaaactccc     3240

actctcaggt gcaagagtta tgtagaagga aagggagctg aaataggaac agaaaaatca     3300

acccctataa ctagtgaaca ccaagggaaa ataccacaat gatttcagag gagactctgc     3360

aaaatcgtcc cttgtggaga atgcaggcaa catggaatac taggaatgaa atcacatcac     3420

tgtatctttt acatcaatag cctcaccact aatatatctt gtatctaggt gtctataatg     3480

gctgaaacca ctacatccat ctatgccatt tacctgaaaa cttaactgtg gcctttatga     3540

ggccagaaaa gtgaactgag ttttcgtagt taagacctca aatgagggga gtcagcagtg     3600

atcatggggg aaatgtttac attttttttt tcttcagaag taacgctttc tgatgatttt     3660

atctgatatt taaaacaggg agctatggtg cactctagtt tatacttgcg ctctgaaatg     3720

tgtaaacata gggtgcctac ctatttcacc tgacccatac tcgtttctga ttcagaatca     3780

gtgtgggctc ctgcagtggg cgcgggtcac ggctgactcc aacttccaat acaacagcca     3840

tcactagcac agtgtttttt tgtttaacca acgtagttgt attagtagtt ctataaagag     3900

aactgctttt aacattaggg actgggagca gtccatggga taaaaaggaa agtgttttct     3960

cacgagaaaa catgtcagga aaaataaaga acactttcta cctctgtttc agatttttga     4020

aacacttatt ttaaaccaaa ttttaatttc tgtgtccaaa ataagtttta aggacatctg     4080

ttcttccata cgaaataggt taggctgcct atttctcact gagctcatgg aatggttctg     4140

cttatgatac tctgcacgct gccttttagt gagtgaggag tttggggttg cctagcaact     4200

tgctaacttg taaaaagtca tctttccctc acagaaagaa acgaaagaaa gcaaagcaaa     4260

gtcagtgaaa gacaatcttt atagtttcag gagtaaatct aaatgtggct tttgtcaagc     4320

acttagatgg atataaatgc agcaacttgt tttaaaaaaa tgcacaattt acttcccaaa     4380

aaagttgtta cttgcctttt caagttgttg acaaacacac atttgatatt ctcttatatg     4440

ttatagtaat gtaacgtata aactcaagcc tttttattct ttgtgattaa atcctgtttt     4500

aaaatgtcac aaaacaggaa ccagcattct aattagattt actatatcaa gatatggttc     4560

aaataggact actagagttc attgaacact aaaactatga aacaattact ttttatatta     4620

aaaagaccat ggatttaact tatgaaaatc caaatgcagg atagtaattt ttgtttactt     4680

ttttaaccaa actgaatttt tgaaagacta ttgcaggtgt ttaaaaagaa agaaaagttg     4740

ttttatctaa tactgtaagt agttgtcata ttctggaaaa tttaatagtt ttagagttaa     4800

gatatctcct ctctttggtt agggaagaag aaagcccttc accattgtgg aatgatgccc     4860

tggctttaag gtttagctcc acatcatgct tctcttgaga attctatttg gtagttacaa     4920

ttacagaaac tgattagttt gtcagtttgc agatagattt agcacagtac tcatcactcg     4980

gatagattga gatgttcttt cacatcagat gatctgtaac actgtaagat actgatcttt     5040

acaactgttt aatcagtttt atttttgtac agtattagtg acctaagtta ttttgctgtc     5100

ccgtttttgt aaatcaaatg aaattataaa agaggattct gacagtaggt attttgtaca     5160

tatgtatata tgttgtccaa ataaaaataa taaatgataa agactgaa                  5208


<210>  44
<211>  2383
<212>  DNA
<213>  Homo sapiens

<400>  44
cgggtcggtg acgtcaccgc atgactgggt ttttatgaat gaaaggaatc ctgtgagtga       60

gtaattccgg gaagctcgcc ttacaactcc gcgcggcctc ggccccctgc gccgcccgcc      120

ccacaacaaa actcagcgca gcgctcccgg gcgcccggtt cagagcgacc tgcggctcag      180

agcggagggg agactgaccg gagcgcggat cgggacagcg gccgggacag cggcgagacg      240

cgcgtgtgtg agcgcgccgg accaagcggg cccagaagcg gatcaagcga gagctgagcg      300

agaacacgcc gcacctgtcg gacgaggcgc tgatggggct gtcggtgcgc gagctgaacc      360

ggcatctgcg cgggctctcc gccgaggagg tgacacggct caagcagcgg cgccgcacac      420

tcaaaaaccg tggctacgcc gccagctgcc gcgtgaagcg cgtgtgccag aaggaggagc      480

tgcagaagca gaagtcggag ctggagcgcg aggtggacaa gctggcgcgc gagaacgccg      540

ccatgcgcct ggagctcgac gcgctgcgcg gcaagtgcga ggcgctgcag ggcttcgcgc      600

gctccgtggc cgccgcccgc gggcccgcca cgctcgtggc gccggccagc gtcatcacca      660

tcgtcaagtc caccccgggc tcggggtctg gccccgccca cggcccggac cccgcccacg      720

gcccggcctc ctgctcctag tgcccgcccc cgccatgcct cagccacgcc cctccggcct      780

cagctccctc cccaaagtgc ctgagcgccg cctctgtgcc caggtcccat ttctctgcag      840

cactggcccc ttggtgcaca cacattccct tcgtgggccc tgtcttcctc ttgcagcccc      900

ccaaactggg accgaatgac cctgggaagg ggaacttggg taggttgggg atggggcaga      960

ggtctggatc tgggatcgcc cttggctgaa agtttagcct ttttagattg agagatacag     1020

agccggctta gagaacagct gttgggggag aagagggcac ccctcatctt ggaaactgct     1080

cttattgtgc caatatgccc tccaaaccct cccaggattc aaagctaggt ttggctgtct     1140

gtgacttacg ggaccgtcct gctgagaaat tgcactgaag agatgccccc acctctggtt     1200

gggcctgggg gtgcctggcc ttccgaaact aaaagagtgg gtgggaagac tagtgaaacc     1260

cagttcacgg atggggaaac aggcctgagg tcacatttca cttagtggtt gtgttgggac     1320

caaaacctgg gtgtcctcac tgctgccctg agtccagcca tggttttcag ggggacagtg     1380

gacagggact cagaaatgtg gtgggagggc ctccctggct tgggagaccg ctctctgcaa     1440

gggaggggga gagaagcaga gggagagaga aggtgacacg gatggaagag tgggaaggag     1500

ctggcctggc tcagccctag gctgtccctg cagccagggt gtccgggggc tggccagtca     1560

gagaaagggg gccatggact gctgtggcaa atagggagac aaggagacag accctgcagt     1620

cctactacag tctggagtgg ggtcctaaga agaagggtcc cacctcaacc cctgtcagtg     1680

tccactgtgg ggtgggggct gacccctgcc tttgattgtc attctcctgg gaagcccagt     1740

ctcagtccct cccccaacac tgtccacact gcccctcccc actgtttatt tattgcacgg     1800

atctaagtta ttctccccag ccagagcccg agctcctgct ccctgggaaa agtggcgtat     1860

ggccctgagc tgggctttat attttatatc tgcaaataaa tcacatttta tcttatattt     1920

agggaaagcc ggagagcaac aacaaaaaat gtttaagccg ggcgcggtgg ctcacatctg     1980

taatcccagc actttgggag tccaaggagg gggatcgctt gagtccagga gtttgagacc     2040

agcctggaca acatggtgaa accccatctc tacaaaaaat acaaaaatta gccatgcatg     2100

gtggctcatg cctgtagtcc cagctacttg ggaggctgag gcaggaggat cacttaagcc     2160

cagaaggcag aggttgtagt gagctgagat cgcaccactg cactccagcc tgggcaacat     2220

agcaaaatcc tgtctcaaaa aaaaagttaa aaaatattgc ccggctccta gaatttattt     2280

atttcctgac ttacagcaag cgagttatcg tcttctgtat tttgtagact ttctaaataa     2340

agtcaaattc tttctttttc cacagagaat aaaaaaaaaa aaa                       2383


<210>  45
<211>  2840
<212>  DNA
<213>  Homo sapiens

<400>  45
tttttcctgg cactgctgag ccacctgcag ttgcgagagc cgctgggagg gataagaggg       60

aagaggacgc ccggtgaagg ggctccagcc tggcagtttc tgcgtgttag catttctaga      120

atagagtggg tgggaactga cccaagtaaa gtcccagaga ctcgaacact gacgcacagg      180

aaagcctcaa gtgggaggag aaatgcaaat cccctactga tgatggcgtc agcggctttc      240

tcctagggac tgtgaggggc gcttctgact ttggacttga gcactgcctg ggacctgtgc      300

tgagagagcg ctagcatgtc tcagtggaat caagtccaac agttagaaat caagtttttg      360

gagcaggtgg atcaattcta tgatgacaac tttcccatgg aaattcggca tctgttggcc      420

caatggattg aaaatcaaga ctgggaggca gcttctaaca atgaaaccat ggcaacgatt      480

cttcttcaaa acttgttaat acaactggat gaacagttag gtcgtgtttc caaagagaaa      540

aacctactct tgatacacaa tctaaaaaga attaggaagg tccttcaggg aaaatttcat      600

ggaaatccaa tgcatgtagc tgtggttatt tcaaactgtt taagggaaga gaggagaata      660

ttggctgcag ccaacatgcc tgtccagggg cctctagaga aatccttaca aagttcttca      720

gtttcagaaa gacagaggaa tgtggagcac aaagtggctg ccattaaaaa cagtgtgcag      780

atgacagaac aagataccaa atacttagaa gatctgcaag acgaatttga ctacaggtat      840

aaaacaattc agacaatgga tcagagtgac aagaatagtg ccatggtgaa tcaggaagtt      900

ttgacactgc aggaaatgct taacagcctc gatttcaaga gaaaggaggc tctcagtaaa      960

atgacccaaa tcatccatga gacagacctg ttaatgaaca ccatgctcat agaagagctg     1020

caagactgga agcggcggca gcaaatcgcc tgcatcgggg gtccactcca caatgggctc     1080

gaccagcttc agaactgctt tacactattg gcagaaagtc ttttccaact gagaaggcaa     1140

ttggagaaac tagaggagca atctaccaaa atgacatatg aaggtgatcc cattccaatg     1200

caaagaactc acatgctaga aagagtcacc ttcttgatct acaacctttt caagaactca     1260

tttgtggttg agcgacagcc atgtatgcca acccaccctc agaggccgtt ggtacttaaa     1320

accctaattc agttcactgt aaaactaagg ctactaataa aattgccaga actaaactat     1380

caggtaaagg ttaaggcatc aattgacaag aatgtttcaa ctctaagcaa ccgaagattt     1440

gtactttgtg gaactaatgt caaagccatg tctattgaag aatcttccaa tgggagtctc     1500

tcagtagaat ttcgacattt gcaaccaaag gaaatgaagt ccagtgctgg aggtaaagga     1560

aatgagggct gtcacatggt gactgaagaa cttcattcca taacgtttga aacacagatc     1620

tgcctctatg gcctgaccat agatttggag accagctcat tgcctgtggt gatgatttcc     1680

aatgtcagtc agttacctaa tgcttgggca tccatcattt ggtacaacgt gtcaaccaac     1740

gattcccaga acttggtttt ctttaataat cctccacctg ccacattgag tcaactactg     1800

gaggtgatga gctggcagtt ttcatcgtac gttggtcgtg gtcttaactc agatcaactc     1860

catatgctgg cagagaagct tacagtccaa tctagctaca gtgatggtca cctcacctgg     1920

gccaagttct gcaaggaaca tttacctggt aaatcattta ccttttggac atggcttgaa     1980

gcaatattgg atctaattaa gaaacacatt cttccccttt ggattgatgg gtatgtcatg     2040

ggctttgtta gcaaagagaa ggaacggctg ttgctaaagg ataaaatgcc tggcaccttt     2100

ttattaagat tcagtgaaag ccatctcgga ggaataactt tcacctgggt ggaccattct     2160

gaaagtgggg aagtgagatt ccactctgta gaaccctaca ataaaggccg gttgtctgct     2220

ctgccattcg ctgacatcct gcgagactac aaagttatta tggctgaaaa cattcctgaa     2280

aaccctctga agtacctata tcctgacatt cccaaagaca aagccttcgg taaacactac     2340

agctctcagc cttgcgaagt ttcaagacca acagaaaggg gtgacaaagg ttatgttcct     2400

tctgttttta tccccatctc aacaatccga agtgattcaa cagagccaca ttctccatca     2460

gaccttcttc ccatgtctcc aagtgtgtat gcggtgttga gagaaaacct gagtcccaca     2520

acaattgaaa ctgcaatgaa gtctccttat tctgctgaat gacaggataa actctgacgc     2580

accaagaaag gaagcaaatg aaaaagttta aagactgttc tttgcccaat aaccacattt     2640

tatttcttca gctttgtaaa taccaggttc taggaaatgt ttgacatctg aagctctctt     2700

cacactcccg tggcactcct caattgggag tgttgtgact gaaatgcttg aaaccaaagc     2760

ttcagataaa cttgcaagat aagacaactt taagaaacca gtgttaataa caatattaac     2820

agaagaaaaa aaaaaaaaaa                                                 2840


<210>  46
<211>  4131
<212>  DNA
<213>  Homo sapiens

<400>  46
ggtgcgcgcc gcggcttggg ggagagttga gcgcttttcc cccctctttt tttttttttt       60

cctcttcttc ttaaacaaac cacaaacgga tgtgagggaa ggaaggtgtt tcttttactc      120

ctgagcccag acacctcact ctgttccgtc taagcttgtt ttgctgaaca ctttttttta      180

aaaaaggaaa aagaaaagga gttgcttgat gtgagagtga aatggacgta agattttatc      240

cacctccagc ccagcccgcc gctgcgcccg acgctccctg tctgggacct tctccctgcc      300

tggaccccta ctattgcaac aagtttgacg gtgagaacat gtatatgagc atgacagagc      360

cgagccagga ctatgtgcca gccagccagt cctaccctgg tccaagcctg gaaagtgaag      420

acttcaacat tccaccaatt actcctcctt ccctcccaga ccactcgctg gtgcacctga      480

atgaagttga gtctggttac cattctctgt gtcaccccat gaaccataat ggcctgctac      540

catttcatcc acaaaacatg gacctccctg aaatcacagt ctccaatatg ctgggccagg      600

atggaacact gctttctaat tccatttctg tgatgccaga tatacgaaac ccagaaggaa      660

ctcagtacag ttcccatcct cagatggcag ccatgagacc aaggggccag cctgcagaca      720

tcaggcagca gccaggaatg atgccacatg gccagctgac taccattaac cagtcacagc      780

taagtgctca acttggtttg aatatgggag gaagcaatgt tccccacaac tcaccatctc      840

cacctggaag caagtctgca actccttcac catccagttc agtgcatgaa gatgaaggcg      900

atgatacctc taagatcaat ggtggagaga agcggcctgc ctctgatatg gggaaaaaac      960

caaaaactcc caaaaagaag aagaagaagg atcccaatga gccccagaag cctgtgtctg     1020

cctatgcgtt attctttcgt gatactcagg ccgccatcaa gggccaaaat ccaaacgcta     1080

cctttggcga agtctctaaa attgtggctt caatgtggga cggtttagga gaagagcaaa     1140

aacaggtcta taaaaagaaa accgaggctg cgaagaagga gtacctgaag caactcgcag     1200

catacagagc cagccttgta tccaagagct acagtgaacc tgttgacgtg aagacatctc     1260

aacctcctca gctgatcaat tcgaagccgt cggtgttcca tgggcccagc caggcccact     1320

cggccctgta cctaagttcc cactatcacc aacaaccggg aatgaatcct cacctaactg     1380

ccatgcatcc tagtctcccc aggaacatag cccccaagcc gaataaccaa atgccagtga     1440

ctgtctctat agcaaacatg gctgtgtccc ctcctcctcc cctccagatc agcccgcctc     1500

ttcaccagca tctcaacatg cagcagcacc agccgctcac catgcagcag ccccttggga     1560

accagctccc catgcaggtc cagtctgcct tacactcacc caccatgcag caaggattta     1620

ctcttcaacc cgactatcag actattatca atcctacatc tacagctgca caagttgtca     1680

cccaggcaat ggagtatgtg cgttcggggt gcagaaatcc tcccccacaa ccggtggact     1740

ggaataacga ctactgcagt agtgggggca tgcagaggga caaagcactg taccttactt     1800

gagaatctga acacctcttc tttccactga ggaattcagg gaagtgtttt caccatggat     1860

tgctttgtac agtcaaggca gttctccatt ttattagaaa atacaagttg ctaagcactt     1920

aggaccattt gagcttgtgg gtcacccact ctggaagaaa tagtcatgct tctttattat     1980

ttttttaatc ctttatggac attgtttttc ttcttccctg aaggaaattt ggaccattca     2040

gattttatgt tggttttttg ctgtgaagtg ctgcgctcta gtaactgcct tagcaactgt     2100

agatgtctcg gataaaagtc ctggattttc cattggtttt cataatgggt gtttatatga     2160

aactactaaa gactttttaa atggcttgat gtagcagtca tagcaagttt gtaaatagca     2220

tctatgttac actctcctag agtataaaat gtgaatgttt ttgtagctaa attgtaattg     2280

aaactggctc attccagttt attgatttca caataggggt taaattggca aacattcata     2340

tttttacttc atttttaaaa caactgactg atagttctat attttcaaaa tatttgaaaa     2400

taaaaagtat tcccaagtga ttttaattta aaaacaaatt ggctttgtct cattgatcag     2460

acaaaaagaa actagtatta agggaagcgc aaacacattt attttgtact gcagaaaaat     2520

tgcttttttg tatcactttt tgtgtaatgg ttagtaaatg tcatttaagt ccttttatgt     2580

ataaaactgc caaatgctta cctggtattt tattagatgc agaaacagat tggaaacagc     2640

taaattacaa cttttacata tggctctgtc ttattgtttc ttcatactgt gtctgtattt     2700

aatctttttt tatggaacct gttgcgccta tttatgaaat aataaatata ggtgtttgta     2760

agtaaatttg ttagtatttg aaagaggttt ctttgatgtt ttaacttttg ctggcaaaaa     2820

aaaattcacg cttggtgtga atactttatt atttagtttt tacagtaaca tgaataaagc     2880

caaacctgct tttcatttag cagcaaatta aagtaaccag tccttatttc tgcatttctt     2940

tggttgatgc aaacaaaaaa ctattatatt taagaacttt atttcttcat acgacataac     3000

agaattgccc tccaagtcac acaagctcca agactaaaca aacagacagg tcctctgtct     3060

taaaaaggtt acttcttggt tctcagctgg ttctagtcaa ttctgaacca ccaccccccg     3120

ccccccgcaa aaaagtaaaa gtcaaaccaa acttcctcaa gctgcatgct tttcacaaaa     3180

tccagaaagc atttaagaat tgaactaggg gctggaagaa gtgaaaggga agcatctaaa     3240

aatgaaaggt gagtaaccag atagcaaaag aaaagggaaa gccatccaaa tttgaaagct     3300

gttgatagaa attgagattc ttgctgtctt ttgtgcctct acaagctact actcattcca     3360

gaattcctgg gtcttccaag aggattctta aggtaccaga gatttgctag ggaaccaaaa     3420

gtgcttgaga atctgcctga gggcttgcat agctttcaca ttaaaaaaag aaaaagctag     3480

cagatttact cctttttagg ggatcatatc aagaaagtta gtctggttgg aaaccaagag     3540

aatggctgat gtctctttct tggaatatgt gaaataaatt tagcagttta actaaataca     3600

aatatatgca ttgtgtaatc cactcagaat taaacagaca aaaggtatgc ttgctttgga     3660

atgattttag gcattgtaca accttgaatc acttgagcat gtaataacta ataaataatg     3720

cagatccatg tgattattaa aatgactgta gctgagagct ctaattttcc tgtcttgaaa     3780

ctgtataaga actcatgtga ttaagttcac agtttattgt ttgtctgttt agtattttag     3840

aaatatacca gcactactaa ttaactaatg tcttttattt attatattat gataaagtaa     3900

aaatttcact tgcattaagt ctaaactgag aaggtaatta ctgggaggag aatgagcagc     3960

tttgactttg acaggcggtt tgtgcaggaa agcacagtgc cgtgttgttt acagcttttc     4020

tagagcagct gtgcgaccag ggtagagagt gttgaaattc aataccaaat acagtaaaaa     4080

caaatgtaaa taaaagaaaa cacatcatca ataaaactgt tattatgcgt g              4131


<210>  47
<211>  2417
<212>  DNA
<213>  Homo sapiens

<400>  47
gcagcagaga ggagttgagg gcgatgagag cgggtactgc gaactgccgg gcgatgctgt       60

cgctgccgcc gtgatacgga gagcaacagt tccccagcaa cacccctccc cgacacaggc      120

acacaccccc cgacaggcac gcacacccac cccacagtgc ccggctcggc tgcgcctcct      180

ctattggccc aggaagccca cccagccccg ccacgcagag cccagaagga aagaaagcct      240

catgcctgag ccgaggggag caccatggat ctgacaaaaa tgggcatgat ccagctgcag      300

aaccctagcc accccacggg gctactgtgc aaggccaacc agatgcggct ggccgggact      360

ttgtgcgatg tggtcatcat ggtggacagc caggagttcc acgcccaccg gacggtgctg      420

gcctgcacca gcaagatgtt tgagatcctc ttccaccgca atagtcaaca ctatactttg      480

gacttcctct cgccaaagac cttccagcag attctggagt atgcatatac agccacgctg      540

caagccaagg cggaggacct ggatgacctg ctgtatgcgg ccgagatcct ggagatcgag      600

tacctggagg aacagtgcct gaagatgctg gagaccatcc aggcctcaga cgacaatgac      660

acggaggcca ccatggccga tggcggggcc gaggaagaag aggaccgcaa ggctcggtac      720

ctcaagaaca tcttcatctc gaagcattcc agcgaggaga gtgggtatgc cagtgtggct      780

ggacagagcc tccctgggcc catggtggac cagagccctt cagtctccac ttcatttggt      840

ctttcagcca tgagtcccac caaggctgca gtggacagtt tgatgaccat aggacagtct      900

ctcctgcagg gaactcttca gccacctgca gggcccgagg agccaactct ggctgggggt      960

gggcggcacc ctggggtggc tgaggtgaag acggagatga tgcaggtgga tgaggtgccc     1020

agccaggaca gccctggggc agccgagtcc agcatctcag gagggatggg ggacaaggtt     1080

gaggaaagag gcaaagaggg gcctgggacc ccgactcgaa gcagcgtcat caccagtgct     1140

agggagctac actatgggcg agaggagagt gccgagcagg tgccaccccc agctgaggct     1200

ggccaggccc ccactggccg acctgagcac ccagcacccc cgcctgagaa gcatctgggc     1260

atctactccg tgttgcccaa ccacaaggct gacgctgtat tgagcatgcc gtcttccgtg     1320

acctctggcc tccacgtgca gcctgccctg gctgtctcca tggacttcag cacctatggg     1380

gggctgctgc cccagggctt catccagagg gagctgttca gcaagctggg ggagctggct     1440

gtgggcatga agtcagagag ccggaccatc ggagagcagt gcagcgtgtg tggggtcgag     1500

cttcctgata acgaggctgt ggagcagcac aggaagctgc acagtgggat gaagacgtac     1560

gggtgcgagc tctgcgggaa gcggttcctg gatagtttgc ggctgagaat gcacttactg     1620

gctcattcag cgggtgccaa agcctttgtc tgtgatcagt gcggtgcaca gttttcgaag     1680

gaggatgccc tggagacaca caggcagacc catactggca ctgacatggc cgtcttctgt     1740

ctgctgtgtg ggaagcgctt ccaggcgcag agcgcactgc agcagcacat ggaggtccac     1800

gcgggcgtgc gcagctacat ctgcagtgag tgcaaccgca ccttccccag ccacacggct     1860

ctcaaacgcc acctgcgctc acatacaggc gaccacccct acgagtgtga gttctgtggc     1920

agctgcttcc gggatgagag cacactcaag agccacaaac gcatccacac gggtgagaaa     1980

ccctacgagt gcaatggctg tggcaagaag ttcagcctca agcatcagct ggagacgcac     2040

tatagggtgc acacaggtga gaagcccttt gagtgtaagc tctgccacca gcgctcccgg     2100

gactactcgg ccatgatcaa gcacctgaga acgcacaacg gcgcctcgcc ctaccagtgc     2160

accatctgca cagagtactg ccccagcctc tcctccatgc agaagcacat gaagggccac     2220

aagcccgagg agatcccgcc cgactggagg atagagaaga cgtacctcta cctgtgctat     2280

gtgtgaaggg aggcccgcgg cggtggagcc gagcggggag ccaggaaaga agagttggag     2340

tgagatgaag gaaggactat gacaaataaa aaaggaaaag aaaaaaaaaa acagaaggaa     2400

aaggaaaaaa aaaaaaa                                                    2417


<210>  48
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Pro Asn Ser Leu Gln Trp Val Gly Ser Pro Cys Gly Leu His 
1               5                   10                  15      


Gly Pro Tyr Ile Phe Tyr Lys Ala Phe Gln Phe His Leu Glu Gly Lys 
            20                  25                  30          


Pro Arg Ile Leu Ser Leu Gly Asp Phe Phe Phe Val Arg Cys Thr Pro 
        35                  40                  45              


Lys Asp Pro Ile Cys Ile Ala Glu Leu Gln Leu Leu Trp Glu Glu Arg 
    50                  55                  60                  


Thr Ser Arg Gln Leu Leu Ser Ser Ser Lys Leu Tyr Phe Leu Pro Glu 
65                  70                  75                  80  


Asp Thr Pro Gln Gly Arg Asn Ser Asp His Gly Glu Asp Glu Val Ile 
                85                  90                  95      


Ala Val Ser Glu Lys Val Ile Val Lys Leu Glu Asp Leu Val Lys Trp 
            100                 105                 110         


Val His Ser Asp Phe Ser Lys Trp Arg Cys Gly Phe His Ala Gly Pro 
        115                 120                 125             


Val Lys Thr Glu Ala Leu Gly Arg Asn Gly Gln Lys Glu Ala Leu Leu 
    130                 135                 140                 


Lys Tyr Arg Gln Ser Thr Leu Asn Ser Gly Leu Asn Phe Lys Asp Val 
145                 150                 155                 160 


Leu Lys Glu Lys Ala Asp Leu Gly Glu Asp Glu Glu Glu Thr Asn Val 
                165                 170                 175     


Ile Val Leu Ser Tyr Pro Gln Tyr Cys Arg Tyr Arg Ser Met Leu Lys 
            180                 185                 190         


Arg Ile Gln Asp Lys Pro Ser Ser Ile Leu Thr Asp Gln Phe Ala Leu 
        195                 200                 205             


Ala Leu Gly Gly Ile Ala Val Val Ser Arg Asn Pro Gln Ile Leu Tyr 
    210                 215                 220                 


Cys Arg Asp Thr Phe Asp His Pro Thr Leu Ile Glu Asn Glu Ser Ile 
225                 230                 235                 240 


Cys Asp Glu Phe Ala Pro Asn Leu Lys Gly Arg Pro Arg Lys Lys Lys 
                245                 250                 255     


Pro Cys Pro Gln Arg Arg Asp Ser Phe Ser Gly Val Lys Asp Ser Asn 
            260                 265                 270         


Asn Asn Ser Asp Gly Lys Ala Val Ala Lys Val Lys Cys Glu Ala Arg 
        275                 280                 285             


Ser Ala Leu Thr Lys Pro Lys Asn Asn His Asn Cys Lys Lys Val Ser 
    290                 295                 300                 


Asn Glu Glu Lys Pro Lys Val Ala Ile Gly Glu Glu Cys Arg Ala Asp 
305                 310                 315                 320 


Glu Gln Ala Phe Leu Val Ala Leu Tyr Lys Tyr Met Lys Glu Arg Lys 
                325                 330                 335     


Thr Pro Ile Glu Arg Ile Pro Tyr Leu Gly Phe Lys Gln Ile Asn Leu 
            340                 345                 350         


Trp Thr Met Phe Gln Ala Ala Gln Lys Leu Gly Gly Tyr Glu Thr Ile 
        355                 360                 365             


Thr Ala Arg Arg Gln Trp Lys His Ile Tyr Asp Glu Leu Gly Gly Asn 
    370                 375                 380                 


Pro Gly Ser Thr Ser Ala Ala Thr Cys Thr Arg Arg His Tyr Glu Arg 
385                 390                 395                 400 


Leu Ile Leu Pro Tyr Glu Arg Phe Ile Lys Gly Glu Glu Asp Lys Pro 
                405                 410                 415     


Leu Pro Pro Ile Lys Pro Arg Lys Gln Glu Asn Ser Ser Gln Glu Asn 
            420                 425                 430         


Glu Asn Lys Thr Lys Val Ser Gly Thr Lys Arg Ile Lys His Glu Ile 
        435                 440                 445             


Pro Lys Ser Lys Lys Glu Lys Glu Asn Ala Pro Lys Pro Gln Asp Ala 
    450                 455                 460                 


Ala Glu Val Ser Ser Glu Gln Glu Lys Glu Gln Glu Thr Leu Ile Ser 
465                 470                 475                 480 


Gln Lys Ser Ile Pro Glu Pro Leu Pro Ala Ala Asp Met Lys Lys Lys 
                485                 490                 495     


Ile Glu Gly Tyr Gln Glu Phe Ser Ala Lys Pro Leu Ala Ser Arg Val 
            500                 505                 510         


Asp Pro Glu Lys Asp Asn Glu Thr Asp Gln Gly Ser Asn Ser Glu Lys 
        515                 520                 525             


Val Ala Glu Glu Ala Gly Glu Lys Gly Pro Thr Pro Pro Leu Pro Ser 
    530                 535                 540                 


Ala Pro Leu Ala Pro Glu Lys Asp Ser Ala Leu Val Pro Gly Ala Ser 
545                 550                 555                 560 


Lys Gln Pro Leu Thr Ser Pro Ser Ala Leu Val Asp Ser Lys Gln Glu 
                565                 570                 575     


Ser Lys Leu Cys Cys Phe Thr Glu Ser Pro Glu Ser Glu Pro Gln Glu 
            580                 585                 590         


Ala Ser Phe Pro Ser Phe Pro Thr Thr Gln Pro Pro Leu Ala Asn Gln 
        595                 600                 605             


Asn Glu Thr Glu Asp Asp Lys Leu Pro Ala Met Ala Asp Tyr Ile Ala 
    610                 615                 620                 


Asn Cys Thr Val Lys Val Asp Gln Leu Gly Ser Asp Asp Ile His Asn 
625                 630                 635                 640 


Ala Leu Lys Gln Thr Pro Lys Val Leu Val Val Gln Ser Phe Asp Met 
                645                 650                 655     


Phe Lys Asp Lys Asp Leu Thr Gly Pro Met Asn Glu Asn His Gly Leu 
            660                 665                 670         


Asn Tyr Thr Pro Leu Leu Tyr Ser Arg Gly Asn Pro Gly Ile Met Ser 
        675                 680                 685             


Pro Leu Ala Lys Lys Lys Leu Leu Ser Gln Val Ser Gly Ala Ser Leu 
    690                 695                 700                 


Ser Ser Ser Tyr Pro Tyr Gly Ser Pro Pro Pro Leu Ile Ser Lys Lys 
705                 710                 715                 720 


Lys Leu Ile Ala Arg Asp Asp Leu Cys Ser Ser Leu Ser Gln Thr His 
                725                 730                 735     


His Gly Gln Ser Thr Asp His Met Ala Val Ser Arg Pro Ser Val Ile 
            740                 745                 750         


Gln His Val Gln Ser Phe Arg Ser Lys Pro Ser Glu Glu Arg Lys Thr 
        755                 760                 765             


Ile Asn Asp Ile Phe Lys His Glu Lys Leu Ser Arg Ser Asp Pro His 
    770                 775                 780                 


Arg Cys Ser Phe Ser Lys His His Leu Asn Pro Leu Ala Asp Ser Tyr 
785                 790                 795                 800 


Val Leu Lys Gln Glu Ile Gln Glu Gly Lys Asp Lys Leu Leu Glu Lys 
                805                 810                 815     


Arg Ala Leu Pro His Ser His Met Pro Ser Phe Leu Ala Asp Phe Tyr 
            820                 825                 830         


Ser Ser Pro His Leu His Ser Leu Tyr Arg His Thr Glu His His Leu 
        835                 840                 845             


His Asn Glu Gln Thr Ser Lys Tyr Pro Ser Arg Asp Met Tyr Arg Glu 
    850                 855                 860                 


Ser Glu Asn Ser Ser Phe Pro Ser His Arg His Gln Glu Lys Leu His 
865                 870                 875                 880 


Val Asn Tyr Leu Thr Ser Leu His Leu Gln Asp Lys Lys Ser Ala Ala 
                885                 890                 895     


Ala Glu Ala Pro Thr Asp Asp Gln Pro Thr Asp Leu Ser Leu Pro Lys 
            900                 905                 910         


Asn Pro His Lys Pro Thr Gly Lys Val Leu Gly Leu Ala His Ser Thr 
        915                 920                 925             


Thr Gly Pro Gln Glu Ser Lys Gly Ile Ser Gln Phe Gln Val Leu Gly 
    930                 935                 940                 


Ser Gln Ser Arg Asp Cys His Pro Lys Ala Cys Arg Val Ser Pro Met 
945                 950                 955                 960 


Thr Met Ser Gly Pro Lys Lys Tyr Pro Glu Ser Leu Ser Arg Ser Gly 
                965                 970                 975     


Lys Pro His His Val Arg Leu Glu Asn Phe Arg Lys Met Glu Gly Met 
            980                 985                 990         


Val His Pro Ile Leu His Arg Lys  Met Ser Pro Gln Asn  Ile Gly Ala 
        995                 1000                 1005             


Ala Arg  Pro Ile Lys Arg Ser  Leu Glu Asp Leu Asp  Leu Val Ile 
    1010                 1015                 1020             


Ala Gly  Lys Lys Ala Arg Ala  Val Ser Pro Leu Asp  Pro Ser Lys 
    1025                 1030                 1035             


Glu Val  Ser Gly Lys Glu Lys  Ala Ser Glu Gln Glu  Ser Glu Gly 
    1040                 1045                 1050             


Ser Lys  Ala Ala His Gly Gly  His Ser Gly Gly Gly  Ser Glu Gly 
    1055                 1060                 1065             


His Lys  Leu Pro Leu Ser Ser  Pro Ile Phe Pro Gly  Leu Tyr Ser 
    1070                 1075                 1080             


Gly Ser  Leu Cys Asn Ser Gly  Leu Asn Ser Arg Leu  Pro Ala Gly 
    1085                 1090                 1095             


Tyr Ser  His Ser Leu Gln Tyr  Leu Lys Asn Gln Thr  Val Leu Ser 
    1100                 1105                 1110             


Pro Leu  Met Gln Pro Leu Ala  Phe His Ser Leu Val  Met Gln Arg 
    1115                 1120                 1125             


Gly Ile  Phe Thr Ser Pro Thr  Asn Ser Gln Gln Leu  Tyr Arg His 
    1130                 1135                 1140             


Leu Ala  Ala Ala Thr Pro Val  Gly Ser Ser Tyr Gly  Asp Leu Leu 
    1145                 1150                 1155             


His Asn  Ser Ile Tyr Pro Leu  Ala Ala Ile Asn Pro  Gln Ala Ala 
    1160                 1165                 1170             


Phe Pro  Ser Ser Gln Leu Ser  Ser Val His Pro Ser  Thr Lys Leu 
    1175                 1180                 1185             


<210>  49
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Met Leu Gln His Pro Gly Gln Val Ser Ala Ser Glu Val Ser Ala 
1               5                   10                  15      


Ser Ala Ile Val Pro Cys Leu Ser Pro Pro Gly Ser Leu Val Phe Glu 
            20                  25                  30          


Asp Phe Ala Asn Leu Thr Pro Phe Val Lys Glu Glu Leu Arg Phe Ala 
        35                  40                  45              


Ile Gln Asn Lys His Leu Cys His Arg Met Ser Ser Ala Leu Glu Ser 
    50                  55                  60                  


Val Thr Val Ser Asp Arg Pro Leu Gly Val Ser Ile Thr Lys Ala Glu 
65                  70                  75                  80  


Val Ala Pro Glu Glu Asp Glu Arg Lys Lys Arg Arg Arg Glu Arg Asn 
                85                  90                  95      


Lys Ile Ala Ala Ala Lys Cys Arg Asn Lys Lys Lys Glu Lys Thr Glu 
            100                 105                 110         


Cys Leu Gln Lys Glu Ser Glu Lys Leu Glu Ser Val Asn Ala Glu Leu 
        115                 120                 125             


Lys Ala Gln Ile Glu Glu Leu Lys Asn Glu Lys Gln His Leu Ile Tyr 
    130                 135                 140                 


Met Leu Asn Leu His Arg Pro Thr Cys Ile Val Arg Ala Gln Asn Gly 
145                 150                 155                 160 


Arg Thr Pro Glu Asp Glu Arg Asn Leu Phe Ile Gln Gln Ile Lys Glu 
                165                 170                 175     


Gly Thr Leu Gln Ser 
            180     


<210>  50
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Gly Ser Ser Pro Leu Leu Asp Ile Val Gly Gly Arg Lys 
            20                  25                  30          


Ala Arg Pro Arg Gln Phe Pro Phe Leu Ala Ser Ile Gln Asn Gln Gly 
        35                  40                  45              


Arg His Phe Cys Gly Gly Ala Leu Ile His Ala Arg Phe Val Met Thr 
    50                  55                  60                  


Ala Ala Ser Cys Phe Gln Ser Gln Asn Pro Gly Val Ser Thr Val Val 
65                  70                  75                  80  


Leu Gly Ala Tyr Asp Leu Arg Arg Arg Glu Arg Gln Ser Arg Gln Thr 
                85                  90                  95      


Phe Ser Ile Ser Ser Met Ser Glu Asn Gly Tyr Asp Pro Gln Gln Asn 
            100                 105                 110         


Leu Asn Asp Leu Met Leu Leu Gln Leu Asp Arg Glu Ala Asn Leu Thr 
        115                 120                 125             


Ser Ser Val Thr Ile Leu Pro Leu Pro Leu Gln Asn Ala Thr Val Glu 
    130                 135                 140                 


Ala Gly Thr Arg Cys Gln Val Ala Gly Trp Gly Ser Gln Arg Ser Gly 
145                 150                 155                 160 


Gly Arg Leu Ser Arg Phe Pro Arg Phe Val Asn Val Thr Val Thr Pro 
                165                 170                 175     


Glu Asp Gln Cys Arg Pro Asn Asn Val Cys Thr Gly Val Leu Thr Arg 
            180                 185                 190         


Arg Gly Gly Ile Cys Asn Gly Asp Gly Gly Thr Pro Leu Val Cys Glu 
        195                 200                 205             


Gly Leu Ala His Gly Val Ala Ser Phe Ser Leu Gly Pro Cys Gly Arg 
    210                 215                 220                 


Gly Pro Asp Phe Phe Thr Arg Val Ala Leu Phe Arg Asp Trp Ile Asp 
225                 230                 235                 240 


Gly Val Leu Asn Asn Pro Gly Pro Gly Pro Ala 
                245                 250     


<210>  51
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  51

Met His Arg Thr Thr Arg Ile Lys Ile Thr Glu Leu Asn Pro His Leu 
1               5                   10                  15      


Met Cys Val Leu Cys Gly Gly Tyr Phe Ile Asp Ala Thr Thr Ile Ile 
            20                  25                  30          


Glu Cys Leu His Ser Phe Cys Lys Thr Cys Ile Val Arg Tyr Leu Glu 
        35                  40                  45              


Thr Ser Lys Tyr Cys Pro Ile Cys Asp Val Gln Val His Lys Thr Arg 
    50                  55                  60                  


Pro Leu Leu Asn Ile Arg Ser Asp Lys Thr Leu Gln Asp Ile Val Tyr 
65                  70                  75                  80  


Lys Leu Val Pro Gly Leu Phe Lys Asn Glu Met Lys Arg Arg Arg Asp 
                85                  90                  95      


Phe Tyr Ala Ala His Pro Ser Ala Asp Ala Ala Asn Gly Ser Asn Glu 
            100                 105                 110         


Asp Arg Gly Glu Val Ala Asp Glu Asp Lys Arg Ile Ile Thr Asp Asp 
        115                 120                 125             


Glu Ile Ile Ser Leu Ser Ile Glu Phe Phe Asp Gln Asn Arg Leu Asp 
    130                 135                 140                 


Arg Lys Val Asn Lys Asp Lys Glu Lys Ser Lys Glu Glu Val Asn Asp 
145                 150                 155                 160 


Lys Arg Tyr Leu Arg Cys Pro Ala Ala Met Thr Val Met His Leu Arg 
                165                 170                 175     


Lys Phe Leu Arg Ser Lys Met Asp Ile Pro Asn Thr Phe Gln Ile Asp 
            180                 185                 190         


Val Met Tyr Glu Glu Glu Pro Leu Lys Asp Tyr Tyr Thr Leu Met Asp 
        195                 200                 205             


Ile Ala Tyr Ile Tyr Thr Trp Arg Arg Asn Gly Pro Leu Pro Leu Lys 
    210                 215                 220                 


Tyr Arg Val Arg Pro Thr Cys Lys Arg Met Lys Ile Ser His Gln Arg 
225                 230                 235                 240 


Asp Gly Leu Thr Asn Ala Gly Glu Leu Glu Ser Asp Ser Gly Ser Asp 
                245                 250                 255     


Lys Ala Asn Ser Pro Ala Gly Gly Ile Pro Ser Thr Ser Ser Cys Leu 
            260                 265                 270         


Pro Ser Pro Ser Thr Pro Val Gln Ser Pro His Pro Gln Phe Pro His 
        275                 280                 285             


Ile Ser Ser Thr Met Asn Gly Thr Ser Asn Ser Pro Ser Gly Asn His 
    290                 295                 300                 


Gln Ser Ser Phe Ala Asn Arg Pro Arg Lys Ser Ser Val Asn Gly Ser 
305                 310                 315                 320 


Ser Ala Thr Ser Ser Gly 
                325     


<210>  52
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gln Ala Ala Trp Leu Leu Gly Ala Leu Val Val Pro Gln Leu Leu 
1               5                   10                  15      


Gly Phe Gly His Gly Ala Arg Gly Ala Glu Arg Glu Trp Glu Gly Gly 
            20                  25                  30          


Trp Gly Gly Ala Gln Glu Glu Glu Arg Glu Arg Glu Ala Leu Met Leu 
        35                  40                  45              


Lys His Leu Gln Glu Ala Leu Gly Leu Pro Ala Gly Arg Gly Asp Glu 
    50                  55                  60                  


Asn Pro Ala Gly Thr Val Glu Gly Lys Glu Asp Trp Glu Met Glu Glu 
65                  70                  75                  80  


Asp Gln Gly Glu Glu Glu Glu Glu Glu Ala Thr Pro Thr Pro Ser Ser 
                85                  90                  95      


Gly Pro Ser Pro Ser Pro Thr Pro Glu Asp Ile Val Thr Tyr Ile Leu 
            100                 105                 110         


Gly Arg Leu Ala Gly Leu Asp Ala Gly Leu His Gln Leu His Val Arg 
        115                 120                 125             


Leu His Ala Leu Asp Thr Arg Val Val Glu Leu Thr Gln Gly Leu Arg 
    130                 135                 140                 


Gln Leu Arg Asn Ala Ala Gly Asp Thr Arg Asp Ala Val Gln Ala Leu 
145                 150                 155                 160 


Gln Glu Ala Gln Gly Arg Ala Glu Arg Glu His Gly Arg Leu Glu Gly 
                165                 170                 175     


Cys Leu Lys Gly Leu Arg Leu Gly His Lys Cys Phe Leu Leu Ser Arg 
            180                 185                 190         


Asp Phe Glu Ala Gln Ala Ala Ala Gln Ala Arg Cys Thr Ala Arg Gly 
        195                 200                 205             


Gly Ser Leu Ala Gln Pro Ala Asp Arg Gln Gln Met Glu Ala Leu Thr 
    210                 215                 220                 


Arg Tyr Leu Arg Ala Ala Leu Ala Pro Tyr Asn Trp Pro Val Trp Leu 
225                 230                 235                 240 


Gly Val His Asp Arg Arg Ala Glu Gly Leu Tyr Leu Phe Glu Asn Gly 
                245                 250                 255     


Gln Arg Val Ser Phe Phe Ala Trp His Arg Ser Pro Arg Pro Glu Leu 
            260                 265                 270         


Gly Ala Gln Pro Ser Ala Ser Pro His Pro Leu Ser Pro Asp Gln Pro 
        275                 280                 285             


Asn Gly Gly Thr Leu Glu Asn Cys Val Ala Gln Ala Ser Asp Asp Gly 
    290                 295                 300                 


Ser Trp Trp Asp His Asp Cys Gln Arg Arg Leu Tyr Tyr Val Cys Glu 
305                 310                 315                 320 


Phe Pro Phe 
            


<210>  53
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ile Pro Gly Gly Leu Ser Glu Ala Lys Pro Ala Thr Pro Glu Ile 
1               5                   10                  15      


Gln Glu Ile Val Asp Lys Val Lys Pro Gln Leu Glu Glu Lys Thr Asn 
            20                  25                  30          


Glu Thr Tyr Gly Lys Leu Glu Ala Val Gln Tyr Lys Thr Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Tyr Ile Lys Val Arg Ala Gly Asp Asn Lys Tyr 
    50                  55                  60                  


Met His Leu Lys Val Phe Lys Ser Leu Pro Gly Gln Asn Glu Asp Leu 
65                  70                  75                  80  


Val Leu Thr Gly Tyr Gln Val Asp Lys Asn Lys Asp Asp Glu Leu Thr 
                85                  90                  95      


Gly Phe 
        


<210>  54
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Asp Gly Phe Tyr Asp Gln Gln Val Pro Phe Met Val Pro Gly Lys 
1               5                   10                  15      


Ser Arg Ser Glu Glu Cys Arg Gly Arg Pro Val Ile Asp Arg Lys Arg 
            20                  25                  30          


Lys Phe Leu Asp Thr Asp Leu Ala His Asp Ser Glu Glu Leu Phe Gln 
        35                  40                  45              


Asp Leu Ser Gln Leu Gln Glu Ala Trp Leu Ala Glu Ala Gln Val Pro 
    50                  55                  60                  


Asp Asp Glu Gln Phe Val Pro Asp Phe Gln Ser Asp Asn Leu Val Leu 
65                  70                  75                  80  


His Ala Pro Pro Pro Thr Lys Ile Lys Arg Glu Leu His Ser Pro Ser 
                85                  90                  95      


Ser Glu Leu Ser Ser Cys Ser His Glu Gln Ala Leu Gly Ala Asn Tyr 
            100                 105                 110         


Gly Glu Lys Cys Leu Tyr Asn Tyr Cys Ala Tyr Asp Arg Lys Pro Pro 
        115                 120                 125             


Ser Gly Phe Lys Pro Leu Thr Pro Pro Thr Thr Pro Leu Ser Pro Thr 
    130                 135                 140                 


His Gln Asn Pro Leu Phe Pro Pro Pro Gln Ala Thr Leu Pro Thr Ser 
145                 150                 155                 160 


Gly His Ala Pro Ala Ala Gly Pro Val Gln Gly Val Gly Pro Ala Pro 
                165                 170                 175     


Ala Pro His Ser Leu Pro Glu Pro Gly Pro Gln Gln Gln Thr Phe Ala 
            180                 185                 190         


Val Pro Arg Pro Pro His Gln Pro Leu Gln Met Pro Lys Met Met Pro 
        195                 200                 205             


Glu Asn Gln Tyr Pro Ser Glu Gln Arg Phe Gln Arg Gln Leu Ser Glu 
    210                 215                 220                 


Pro Cys His Pro Phe Pro Pro Gln Pro Gly Val Pro Gly Asp Asn Arg 
225                 230                 235                 240 


Pro Ser Tyr His Arg Gln Met Ser Glu Pro Ile Val Pro Ala Ala Pro 
                245                 250                 255     


Pro Pro Pro Gln Gly Phe Lys Gln Glu Tyr His Asp Pro Leu Tyr Glu 
            260                 265                 270         


His Gly Val Pro Gly Met Pro Gly Pro Pro Ala His Gly Phe Gln Ser 
        275                 280                 285             


Pro Met Gly Ile Lys Gln Glu Pro Arg Asp Tyr Cys Val Asp Ser Glu 
    290                 295                 300                 


Val Pro Asn Cys Gln Ser Ser Tyr Met Arg Gly Gly Tyr Phe Ser Ser 
305                 310                 315                 320 


Ser His Glu Gly Phe Ser Tyr Glu Lys Asp Pro Arg Leu Tyr Phe Asp 
                325                 330                 335     


Asp Thr Cys Val Val Pro Glu Arg Leu Glu Gly Lys Val Lys Gln Glu 
            340                 345                 350         


Pro Thr Met Tyr Arg Glu Gly Pro Pro Tyr Gln Arg Arg Gly Ser Leu 
        355                 360                 365             


Gln Leu Trp Gln Phe Leu Val Thr Leu Leu Asp Asp Pro Ala Asn Ala 
    370                 375                 380                 


His Phe Ile Ala Trp Thr Gly Arg Gly Met Glu Phe Lys Leu Ile Glu 
385                 390                 395                 400 


Pro Glu Glu Val Ala Arg Arg Trp Gly Ile Gln Lys Asn Arg Pro Ala 
                405                 410                 415     


Met Asn Tyr Asp Lys Leu Ser Arg Ser Leu Arg Tyr Tyr Tyr Glu Lys 
            420                 425                 430         


Gly Ile Met Gln Lys Val Ala Gly Glu Arg Tyr Val Tyr Lys Phe Val 
        435                 440                 445             


Cys Asp Pro Asp Ala Leu Phe Ser Met Ala Phe Pro Asp Asn Gln Arg 
    450                 455                 460                 


Pro Phe Leu Lys Ala Glu Ser Glu Cys His Leu Ser Glu Glu Asp Thr 
465                 470                 475                 480 


Leu Pro Leu Thr His Phe Glu Asp Ser Pro Ala Tyr Leu Leu Asp Met 
                485                 490                 495     


Asp Arg Cys Ser Ser Leu Pro Tyr Ala Glu Gly Phe Ala Tyr 
            500                 505                 510 


<210>  55
<211>  2406
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Asp Pro Glu Gln Ser Val Lys Gly Thr Lys Lys Ala Glu Gly Ser 
1               5                   10                  15      


Pro Arg Lys Arg Leu Thr Lys Gly Glu Ala Ile Gln Thr Ser Val Ser 
            20                  25                  30          


Ser Ser Val Pro Tyr Pro Gly Ser Gly Thr Ala Ala Thr Gln Glu Ser 
        35                  40                  45              


Pro Ala Gln Glu Leu Leu Ala Pro Gln Pro Phe Pro Gly Pro Ser Ser 
    50                  55                  60                  


Val Leu Arg Glu Gly Ser Gln Glu Lys Thr Gly Gln Gln Gln Lys Pro 
65                  70                  75                  80  


Pro Lys Arg Pro Pro Ile Glu Ala Ser Val His Ile Ser Gln Leu Pro 
                85                  90                  95      


Gln His Pro Leu Thr Pro Ala Phe Met Ser Pro Gly Lys Pro Glu His 
            100                 105                 110         


Leu Leu Glu Gly Ser Thr Trp Gln Leu Val Asp Pro Met Arg Pro Gly 
        115                 120                 125             


Pro Ser Gly Ser Phe Val Ala Pro Gly Leu His Pro Gln Ser Gln Leu 
    130                 135                 140                 


Leu Pro Ser His Ala Ser Ile Ile Pro Pro Glu Asp Leu Pro Gly Val 
145                 150                 155                 160 


Pro Lys Val Phe Val Pro Arg Pro Ser Gln Val Ser Leu Lys Pro Thr 
                165                 170                 175     


Glu Glu Ala His Lys Lys Glu Arg Lys Pro Gln Lys Pro Gly Lys Tyr 
            180                 185                 190         


Ile Cys Gln Tyr Cys Ser Arg Pro Cys Ala Lys Pro Ser Val Leu Gln 
        195                 200                 205             


Lys His Ile Arg Ser His Thr Gly Glu Arg Pro Tyr Pro Cys Gly Pro 
    210                 215                 220                 


Cys Gly Phe Ser Phe Lys Thr Lys Ser Asn Leu Tyr Lys His Arg Lys 
225                 230                 235                 240 


Ser His Ala His Arg Ile Lys Ala Gly Leu Ala Ser Gly Met Gly Gly 
                245                 250                 255     


Glu Met Tyr Pro His Gly Leu Glu Met Glu Arg Ile Pro Gly Glu Glu 
            260                 265                 270         


Phe Glu Glu Pro Thr Glu Gly Glu Ser Thr Asp Ser Glu Glu Glu Thr 
        275                 280                 285             


Ser Ala Thr Ser Gly His Pro Ala Glu Leu Ser Pro Arg Pro Lys Gln 
    290                 295                 300                 


Pro Leu Leu Ser Ser Gly Leu Tyr Ser Ser Gly Ser His Ser Ser Ser 
305                 310                 315                 320 


His Glu Arg Cys Ser Leu Ser Gln Ser Ser Thr Ala Gln Ser Leu Glu 
                325                 330                 335     


Asp Pro Pro Pro Phe Val Glu Pro Ser Ser Glu His Pro Leu Ser His 
            340                 345                 350         


Lys Pro Glu Asp Thr His Thr Ile Lys Gln Lys Leu Ala Leu Arg Leu 
        355                 360                 365             


Ser Glu Arg Lys Lys Val Ile Asp Glu Gln Ala Phe Leu Ser Pro Gly 
    370                 375                 380                 


Ser Lys Gly Ser Thr Glu Ser Gly Tyr Phe Ser Arg Ser Glu Ser Ala 
385                 390                 395                 400 


Glu Gln Gln Val Ser Pro Pro Asn Thr Asn Ala Lys Ser Tyr Ala Glu 
                405                 410                 415     


Ile Ile Phe Gly Lys Cys Gly Arg Ile Gly Gln Arg Thr Ala Met Leu 
            420                 425                 430         


Thr Ala Thr Ser Thr Gln Pro Leu Leu Pro Leu Ser Thr Glu Asp Lys 
        435                 440                 445             


Pro Ser Leu Val Pro Leu Ser Val Pro Arg Thr Gln Val Ile Glu His 
    450                 455                 460                 


Ile Thr Lys Leu Ile Thr Ile Asn Glu Ala Val Val Asp Thr Ser Glu 
465                 470                 475                 480 


Ile Asp Ser Val Lys Pro Arg Arg Ser Ser Leu Ser Arg Arg Ser Ser 
                485                 490                 495     


Met Glu Ser Pro Lys Ser Ser Leu Tyr Arg Glu Pro Leu Ser Ser His 
            500                 505                 510         


Ser Glu Lys Thr Lys Pro Glu Gln Ser Leu Leu Ser Leu Gln His Pro 
        515                 520                 525             


Pro Ser Thr Ala Pro Pro Val Pro Leu Leu Arg Ser His Ser Met Pro 
    530                 535                 540                 


Ser Ala Ala Cys Thr Ile Ser Thr Pro His His Pro Phe Arg Gly Ser 
545                 550                 555                 560 


Tyr Ser Phe Asp Asp His Ile Thr Asp Ser Glu Ala Leu Ser His Ser 
                565                 570                 575     


Ser His Val Phe Thr Ser His Pro Arg Met Leu Lys Arg Gln Pro Ala 
            580                 585                 590         


Ile Glu Leu Pro Leu Gly Gly Glu Tyr Ser Ser Glu Glu Pro Gly Pro 
        595                 600                 605             


Ser Ser Lys Asp Thr Ala Ser Lys Pro Ser Asp Glu Val Glu Pro Lys 
    610                 615                 620                 


Glu Ser Glu Leu Thr Lys Lys Thr Lys Lys Gly Leu Lys Thr Lys Gly 
625                 630                 635                 640 


Val Ile Tyr Glu Cys Asn Ile Cys Gly Ala Arg Tyr Lys Lys Arg Asp 
                645                 650                 655     


Asn Tyr Glu Ala His Lys Lys Tyr Tyr Cys Ser Glu Leu Gln Ile Ala 
            660                 665                 670         


Lys Pro Ile Ser Ala Gly Thr His Thr Ser Pro Glu Ala Glu Lys Ser 
        675                 680                 685             


Gln Ile Glu His Glu Pro Trp Ser Gln Met Met His Tyr Lys Leu Gly 
    690                 695                 700                 


Thr Thr Leu Glu Leu Thr Pro Leu Arg Lys Arg Arg Lys Glu Lys Ser 
705                 710                 715                 720 


Leu Gly Asp Glu Glu Glu Pro Pro Ala Phe Glu Ser Thr Lys Ser Gln 
                725                 730                 735     


Phe Gly Ser Pro Gly Pro Ser Asp Ala Ala Arg Asn Leu Pro Leu Glu 
            740                 745                 750         


Ser Thr Lys Ser Pro Ala Glu Pro Ser Lys Ser Val Pro Ser Leu Glu 
        755                 760                 765             


Gly Pro Thr Gly Phe Gln Pro Arg Thr Pro Lys Pro Gly Ser Gly Ser 
    770                 775                 780                 


Glu Ser Gly Lys Glu Arg Arg Thr Thr Ser Lys Glu Ile Ser Val Ile 
785                 790                 795                 800 


Gln His Thr Ser Ser Phe Glu Lys Ser Asp Ser Leu Glu Gln Pro Ser 
                805                 810                 815     


Gly Leu Glu Gly Glu Asp Lys Pro Leu Ala Gln Phe Pro Ser Pro Pro 
            820                 825                 830         


Pro Ala Pro His Gly Arg Ser Ala His Ser Leu Gln Pro Lys Leu Val 
        835                 840                 845             


Arg Gln Pro Asn Ile Gln Val Pro Glu Ile Leu Val Thr Glu Glu Pro 
    850                 855                 860                 


Asp Arg Pro Asp Thr Glu Pro Glu Pro Pro Pro Lys Glu Pro Glu Lys 
865                 870                 875                 880 


Thr Glu Glu Phe Gln Trp Pro Gln Arg Ser Gln Thr Leu Ala Gln Leu 
                885                 890                 895     


Pro Ala Glu Lys Leu Pro Pro Lys Lys Lys Arg Leu Arg Leu Ala Glu 
            900                 905                 910         


Met Ala Gln Ser Ser Gly Glu Ser Ser Phe Glu Ser Ser Val Pro Leu 
        915                 920                 925             


Ser Arg Ser Pro Ser Gln Glu Ser Asn Val Ser Leu Ser Gly Ser Ser 
    930                 935                 940                 


Arg Ser Ala Ser Phe Glu Arg Asp Asp His Gly Lys Ala Glu Ala Pro 
945                 950                 955                 960 


Ser Pro Ser Ser Asp Met Arg Pro Lys Pro Leu Gly Thr His Met Leu 
                965                 970                 975     


Thr Val Pro Ser His His Pro His Ala Arg Glu Met Arg Arg Ser Ala 
            980                 985                 990         


Ser Glu Gln Ser Pro Asn Val Ser  His Ser Ala His Met  Thr Glu Thr 
        995                 1000                 1005             


Arg Ser  Lys Ser Phe Asp Tyr  Gly Ser Leu Ser Leu  Thr Gly Pro 
    1010                 1015                 1020             


Ser Ala  Pro Ala Pro Val Ala  Pro Pro Ala Arg Val  Ala Pro Pro 
    1025                 1030                 1035             


Glu Arg  Arg Lys Cys Phe Leu  Val Arg Gln Ala Ser  Leu Ser Arg 
    1040                 1045                 1050             


Pro Pro  Glu Ser Glu Leu Glu  Val Ala Pro Lys Gly  Arg Gln Glu 
    1055                 1060                 1065             


Ser Glu  Glu Pro Gln Pro Ser  Ser Ser Lys Pro Ser  Ala Lys Ser 
    1070                 1075                 1080             


Ser Leu  Ser Gln Ile Ser Ser  Ala Ala Thr Ser His  Gly Gly Pro 
    1085                 1090                 1095             


Pro Gly  Gly Lys Gly Pro Gly  Gln Asp Arg Pro Pro  Leu Gly Pro 
    1100                 1105                 1110             


Thr Val  Pro Tyr Thr Glu Ala  Leu Gln Val Phe His  His Pro Val 
    1115                 1120                 1125             


Ala Gln  Thr Pro Leu His Glu  Lys Pro Tyr Leu Pro  Pro Pro Val 
    1130                 1135                 1140             


Ser Leu  Phe Ser Phe Gln His  Leu Val Gln His Glu  Pro Gly Gln 
    1145                 1150                 1155             


Ser Pro  Glu Phe Phe Ser Thr  Gln Ala Met Ser Ser  Leu Leu Ser 
    1160                 1165                 1170             


Ser Pro  Tyr Ser Met Pro Pro  Leu Pro Pro Ser Leu  Phe Gln Ala 
    1175                 1180                 1185             


Pro Pro  Leu Pro Leu Gln Pro  Thr Val Leu His Pro  Gly Gln Leu 
    1190                 1195                 1200             


His Leu  Pro Gln Leu Met Pro  His Pro Ala Asn Ile  Pro Phe Arg 
    1205                 1210                 1215             


Gln Pro  Pro Ser Phe Leu Pro  Met Pro Tyr Pro Thr  Ser Ser Ala 
    1220                 1225                 1230             


Leu Ser  Ser Gly Phe Phe Leu  Pro Leu Gln Ser Gln  Phe Ala Leu 
    1235                 1240                 1245             


Gln Leu  Pro Gly Asp Val Glu  Ser His Leu Pro Gln  Ile Lys Thr 
    1250                 1255                 1260             


Ser Leu  Ala Pro Leu Ala Thr  Gly Ser Ala Gly Leu  Ser Pro Ser 
    1265                 1270                 1275             


Thr Glu  Tyr Ser Ser Asp Ile  Arg Leu Pro Pro Val  Ala Pro Pro 
    1280                 1285                 1290             


Ala Ser  Ser Ser Ala Pro Thr  Ser Ala Pro Pro Leu  Ala Leu Pro 
    1295                 1300                 1305             


Ala Cys  Pro Asp Thr Met Val  Ser Leu Val Val Pro  Val Arg Val 
    1310                 1315                 1320             


Gln Thr  Asn Met Pro Ser Tyr  Gly Ser Ala Met Tyr  Thr Thr Leu 
    1325                 1330                 1335             


Ser Gln  Ile Leu Val Thr Gln  Ser Gln Gly Ser Ser  Ala Thr Val 
    1340                 1345                 1350             


Ala Leu  Pro Lys Phe Glu Glu  Pro Pro Ser Lys Gly  Thr Thr Val 
    1355                 1360                 1365             


Cys Gly  Ala Asp Val His Glu  Val Gly Pro Gly Pro  Ser Gly Leu 
    1370                 1375                 1380             


Ser Glu  Glu Gln Ser Arg Ala  Phe Pro Thr Pro Tyr  Leu Arg Val 
    1385                 1390                 1395             


Pro Val  Thr Leu Pro Glu Arg  Lys Gly Thr Ser Leu  Ser Ser Glu 
    1400                 1405                 1410             


Ser Ile  Leu Ser Leu Glu Gly  Ser Ser Ser Thr Ala  Gly Gly Ser 
    1415                 1420                 1425             


Lys Arg  Val Leu Ser Pro Ala  Gly Ser Leu Glu Leu  Thr Met Glu 
    1430                 1435                 1440             


Thr Gln  Gln Gln Lys Arg Val  Lys Glu Glu Glu Ala  Ser Lys Ala 
    1445                 1450                 1455             


Asp Glu  Lys Leu Glu Leu Val  Lys Pro Cys Ser Val  Val Leu Thr 
    1460                 1465                 1470             


Ser Thr  Glu Asp Gly Lys Arg  Pro Glu Lys Ser His  Leu Gly Asn 
    1475                 1480                 1485             


Gln Gly  Gln Gly Arg Arg Glu  Leu Glu Met Leu Ser  Ser Leu Ser 
    1490                 1495                 1500             


Ser Asp  Pro Ser Asp Thr Lys  Glu Ile Pro Pro Leu  Pro His Pro 
    1505                 1510                 1515             


Ala Leu  Ser His Gly Thr Ala  Pro Gly Ser Glu Ala  Leu Lys Glu 
    1520                 1525                 1530             


Tyr Pro  Gln Pro Ser Gly Lys  Pro His Arg Arg Gly  Leu Thr Pro 
    1535                 1540                 1545             


Leu Ser  Val Lys Lys Glu Asp  Ser Lys Glu Gln Pro  Asp Leu Pro 
    1550                 1555                 1560             


Ser Leu  Ala Pro Pro Ser Ser  Leu Pro Leu Ser Glu  Thr Ser Ser 
    1565                 1570                 1575             


Arg Pro  Ala Lys Ser Gln Glu  Gly Thr Asp Ser Lys  Lys Val Leu 
    1580                 1585                 1590             


Gln Phe  Pro Ser Leu His Thr  Thr Thr Asn Val Ser  Trp Cys Tyr 
    1595                 1600                 1605             


Leu Asn  Tyr Ile Lys Pro Asn  His Ile Gln His Ala  Asp Arg Arg 
    1610                 1615                 1620             


Ser Ser  Val Tyr Ala Gly Trp  Cys Ile Ser Leu Tyr  Asn Pro Asn 
    1625                 1630                 1635             


Leu Pro  Gly Val Ser Thr Lys  Ala Ala Leu Ser Leu  Leu Arg Ser 
    1640                 1645                 1650             


Lys Gln  Lys Val Ser Lys Glu  Thr Tyr Thr Met Ala  Thr Ala Pro 
    1655                 1660                 1665             


His Pro  Glu Ala Gly Arg Leu  Val Pro Ser Ser Ser  Arg Lys Pro 
    1670                 1675                 1680             


Arg Met  Thr Glu Val His Leu  Pro Ser Leu Val Ser  Pro Glu Gly 
    1685                 1690                 1695             


Gln Lys  Asp Leu Ala Arg Val  Glu Lys Glu Glu Glu  Arg Arg Gly 
    1700                 1705                 1710             


Glu Pro  Glu Glu Asp Ala Pro  Ala Ser Gln Arg Gly  Glu Pro Ala 
    1715                 1720                 1725             


Arg Ile  Lys Ile Phe Glu Gly  Gly Tyr Lys Ser Asn  Glu Glu Tyr 
    1730                 1735                 1740             


Val Tyr  Val Arg Gly Arg Gly  Arg Gly Lys Tyr Val  Cys Glu Glu 
    1745                 1750                 1755             


Cys Gly  Ile Arg Cys Lys Lys  Pro Ser Met Leu Lys  Lys His Ile 
    1760                 1765                 1770             


Arg Thr  His Thr Asp Val Arg  Pro Tyr Val Cys Lys  His Cys His 
    1775                 1780                 1785             


Phe Ala  Phe Lys Thr Lys Gly  Asn Leu Thr Lys His  Met Lys Ser 
    1790                 1795                 1800             


Lys Ala  His Ser Lys Lys Cys  Gln Glu Thr Gly Val  Leu Glu Glu 
    1805                 1810                 1815             


Leu Glu  Ala Glu Glu Gly Thr  Ser Asp Asp Leu Phe  Gln Asp Ser 
    1820                 1825                 1830             


Glu Gly  Arg Glu Gly Ser Glu  Ala Val Glu Glu His  Gln Phe Ser 
    1835                 1840                 1845             


Asp Leu  Glu Asp Ser Asp Ser  Asp Ser Asp Leu Asp  Glu Asp Glu 
    1850                 1855                 1860             


Asp Glu  Asp Glu Glu Glu Ser  Gln Asp Glu Leu Ser  Arg Pro Ser 
    1865                 1870                 1875             


Ser Glu  Ala Pro Pro Pro Gly  Pro Pro His Ala Leu  Arg Ala Asp 
    1880                 1885                 1890             


Ser Ser  Pro Ile Leu Gly Pro  Gln Pro Pro Asp Ala  Pro Ala Ser 
    1895                 1900                 1905             


Gly Thr  Glu Ala Thr Arg Gly  Ser Ser Val Ser Glu  Ala Glu Arg 
    1910                 1915                 1920             


Leu Thr  Ala Ser Ser Cys Ser  Met Ser Ser Gln Ser  Met Pro Gly 
    1925                 1930                 1935             


Leu Pro  Trp Leu Gly Pro Ala  Pro Leu Gly Ser Val  Glu Lys Asp 
    1940                 1945                 1950             


Thr Gly  Ser Ala Leu Ser Tyr  Lys Pro Val Ser Pro  Arg Arg Pro 
    1955                 1960                 1965             


Trp Ser  Pro Ser Lys Glu Ala  Gly Ser Arg Pro Pro  Leu Ala Arg 
    1970                 1975                 1980             


Lys His  Ser Leu Thr Lys Asn  Asp Ser Ser Pro Gln  Arg Cys Ser 
    1985                 1990                 1995             


Pro Ala  Arg Glu Pro Gln Ala  Ser Ala Pro Ser Pro  Pro Gly Leu 
    2000                 2005                 2010             


His Val  Asp Pro Gly Arg Gly  Met Gly Ala Leu Pro  Cys Gly Ser 
    2015                 2020                 2025             


Pro Arg  Leu Gln Leu Ser Pro  Leu Thr Leu Cys Pro  Leu Gly Arg 
    2030                 2035                 2040             


Glu Leu  Ala Pro Arg Ala His  Val Leu Ser Lys Leu  Glu Gly Thr 
    2045                 2050                 2055             


Thr Asp  Pro Gly Leu Pro Arg  Tyr Ser Pro Thr Arg  Arg Trp Ser 
    2060                 2065                 2070             


Pro Gly  Gln Ala Glu Ser Pro  Pro Arg Ser Ala Pro  Pro Gly Lys 
    2075                 2080                 2085             


Trp Ala  Leu Ala Gly Pro Gly  Ser Pro Ser Ala Gly  Glu His Gly 
    2090                 2095                 2100             


Pro Gly  Leu Gly Leu Asp Pro  Arg Val Leu Phe Pro  Pro Ala Pro 
    2105                 2110                 2115             


Leu Pro  His Lys Leu Leu Ser  Arg Ser Pro Glu Thr  Cys Ala Ser 
    2120                 2125                 2130             


Pro Trp  Gln Lys Ala Glu Ser  Arg Ser Pro Ser Cys  Ser Pro Gly 
    2135                 2140                 2145             


Pro Ala  His Pro Leu Ser Ser  Arg Pro Phe Ser Ala  Leu His Asp 
    2150                 2155                 2160             


Phe His  Gly His Ile Leu Ala  Arg Thr Glu Glu Asn  Ile Phe Ser 
    2165                 2170                 2175             


His Leu  Pro Leu His Ser Gln  His Leu Thr Arg Ala  Pro Cys Pro 
    2180                 2185                 2190             


Leu Ile  Pro Ile Gly Gly Ile  Gln Met Val Gln Ala  Arg Pro Gly 
    2195                 2200                 2205             


Ala His  Pro Thr Leu Leu Pro  Gly Pro Thr Ala Ala  Trp Val Ser 
    2210                 2215                 2220             


Gly Phe  Ser Gly Gly Gly Ser  Asp Leu Thr Gly Ala  Arg Glu Ala 
    2225                 2230                 2235             


Gln Glu  Arg Gly Arg Trp Ser  Pro Thr Glu Ser Ser  Ser Ala Ser 
    2240                 2245                 2250             


Val Ser  Pro Val Ala Lys Val  Ser Lys Phe Thr Leu  Ser Ser Glu 
    2255                 2260                 2265             


Leu Glu  Gly Gly Asp Tyr Pro  Lys Glu Arg Glu Arg  Thr Gly Gly 
    2270                 2275                 2280             


Gly Pro  Gly Arg Pro Pro Asp  Trp Thr Pro His Gly  Thr Gly Ala 
    2285                 2290                 2295             


Pro Ala  Glu Pro Thr Pro Thr  His Ser Pro Cys Thr  Pro Pro Asp 
    2300                 2305                 2310             


Thr Leu  Pro Arg Pro Pro Gln  Gly Arg Arg Ala Ala  Gln Ser Trp 
    2315                 2320                 2325             


Ser Pro  Arg Leu Glu Ser Pro  Arg Ala Pro Thr Asn  Pro Glu Pro 
    2330                 2335                 2340             


Ser Ala  Thr Pro Pro Leu Asp  Arg Ser Ser Ser Val  Gly Cys Leu 
    2345                 2350                 2355             


Ala Glu  Ala Ser Ala Arg Phe  Pro Ala Arg Thr Arg  Asn Leu Ser 
    2360                 2365                 2370             


Gly Glu  Pro Arg Thr Arg Gln  Asp Ser Pro Lys Pro  Ser Gly Ser 
    2375                 2380                 2385             


Gly Glu  Pro Arg Ala His Pro  His Gln Pro Glu Asp  Arg Val Pro 
    2390                 2395                 2400             


Pro Asn  Ala 
    2405     


<210>  56
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gln Lys Ala Thr Tyr Tyr Asp Ser Ser Ala Ile Tyr Gly Gly Tyr 
1               5                   10                  15      


Pro Tyr Gln Ala Ala Asn Gly Phe Ala Tyr Asn Ala Asn Gln Gln Pro 
            20                  25                  30          


Tyr Pro Ala Ser Ala Ala Leu Gly Ala Asp Gly Glu Tyr His Arg Pro 
        35                  40                  45              


Ala Cys Ser Leu Gln Ser Pro Ser Ser Ala Gly Gly His Pro Lys Ala 
    50                  55                  60                  


His Glu Leu Ser Glu Ala Cys Leu Arg Thr Leu Ser Ala Pro Pro Ser 
65                  70                  75                  80  


Gln Pro Pro Ser Leu Gly Glu Pro Pro Leu His Pro Pro Pro Pro Gln 
                85                  90                  95      


Ala Ala Pro Pro Ala Pro Gln Pro Pro Gln Pro Ala Pro Gln Pro Pro 
            100                 105                 110         


Ala Pro Thr Pro Ala Ala Pro Pro Pro Pro Ser Ser Ala Ser Pro Pro 
        115                 120                 125             


Gln Asn Ala Ser Asn Asn Pro Thr Pro Ala Asn Ala Ala Lys Ser Pro 
    130                 135                 140                 


Leu Leu Asn Ser Pro Thr Val Ala Lys Gln Ile Phe Pro Trp Met Lys 
145                 150                 155                 160 


Glu Ser Arg Gln Asn Thr Lys Gln Lys Thr Ser Ser Ser Ser Ser Gly 
                165                 170                 175     


Glu Ser Cys Ala Gly Asp Lys Ser Pro Pro Gly Gln Ala Ser Ser Lys 
            180                 185                 190         


Arg Ala Arg Thr Ala Tyr Thr Ser Ala Gln Leu Val Glu Leu Glu Lys 
        195                 200                 205             


Glu Phe His Phe Asn Arg Tyr Leu Cys Arg Pro Arg Arg Val Glu Met 
    210                 215                 220                 


Ala Asn Leu Leu Asn Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln 
225                 230                 235                 240 


Asn Arg Arg Met Lys Tyr Lys Lys Asp Gln Lys Gly Lys Gly Met Leu 
                245                 250                 255     


Thr Ser Ser Gly Gly Gln Ser Pro Ser Arg Ser Pro Val Pro Pro Gly 
            260                 265                 270         


Ala Gly Gly Tyr Leu Asn Ser Met His Ser Leu Val Asn Ser Val Pro 
        275                 280                 285             


Tyr Glu Pro Gln Ser Pro Pro Pro Phe Ser Lys Pro Pro Gln Gly Thr 
    290                 295                 300                 


Tyr Gly Leu Pro Pro Ala Ser Tyr Pro Ala Ser Leu Pro Ser Cys Ala 
305                 310                 315                 320 


Pro Pro Pro Pro Pro Gln Lys Arg Tyr Thr Ala Ala Gly Ala Gly Ala 
                325                 330                 335     


Gly Gly Thr Pro Asp Tyr Asp Pro His Ala His Gly Leu Gln Gly Asn 
            340                 345                 350         


Gly Ser Tyr Gly Thr Pro His Ile Gln Gly Ser Pro Val Phe Val Gly 
        355                 360                 365             


Gly Ser Tyr Val Glu Pro Met Ser Asn Ser Gly Pro Ala Leu Phe Gly 
    370                 375                 380                 


Leu Thr His Leu Pro His Ala Ala Ser Gly Ala Met Asp Tyr Gly Gly 
385                 390                 395                 400 


Ala Gly Pro Leu Gly Ser Gly His His His Gly Pro Gly Pro Gly Glu 
                405                 410                 415     


Pro His Pro Thr Tyr Thr Asp Leu Thr Gly His His Pro Ser Gln Gly 
            420                 425                 430         


Arg Ile Gln Glu Ala Pro Lys Leu Thr His Leu 
        435                 440             


<210>  57
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ser Ser Tyr Phe Val Asn Pro Thr Phe Pro Gly Ser Leu Pro Ser 
1               5                   10                  15      


Gly Gln Asp Ser Phe Leu Gly Gln Leu Pro Leu Tyr Gln Ala Gly Tyr 
            20                  25                  30          


Asp Ala Leu Arg Pro Phe Pro Ala Ser Tyr Gly Ala Ser Ser Leu Pro 
        35                  40                  45              


Asp Lys Thr Tyr Thr Ser Pro Cys Phe Tyr Gln Gln Ser Asn Ser Val 
    50                  55                  60                  


Leu Ala Cys Asn Arg Ala Ser Tyr Glu Tyr Gly Ala Ser Cys Phe Tyr 
65                  70                  75                  80  


Ser Asp Lys Asp Leu Ser Gly Ala Ser Pro Ser Gly Ser Gly Lys Gln 
                85                  90                  95      


Arg Gly Pro Gly Asp Tyr Leu His Phe Ser Pro Glu Gln Gln Tyr Lys 
            100                 105                 110         


Pro Asp Ser Ser Ser Gly Gln Gly Lys Ala Leu His Asp Glu Gly Ala 
        115                 120                 125             


Asp Arg Lys Tyr Thr Ser Pro Val Tyr Pro Trp Met Gln Arg Met Asn 
    130                 135                 140                 


Ser Cys Ala Gly Ala Val Tyr Gly Ser His Gly Arg Arg Gly Arg Gln 
145                 150                 155                 160 


Thr Tyr Thr Arg Tyr Gln Thr Leu Glu Leu Glu Lys Glu Phe His Phe 
                165                 170                 175     


Asn Arg Tyr Leu Thr Arg Arg Arg Arg Ile Glu Ile Ala Asn Ala Leu 
            180                 185                 190         


Cys Leu Thr Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met 
        195                 200                 205             


Lys Trp Lys Lys Glu Asn Lys Leu Ile Asn Ser Thr Gln Pro Ser Gly 
    210                 215                 220                 


Glu Asp Ser Glu Ala Lys Ala Gly Glu 
225                 230             


<210>  58
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Gln Lys Ala Thr Tyr Tyr Asp Asn Ala Ala Ala Ala Leu Phe Gly 
1               5                   10                  15      


Gly Tyr Ser Ser Tyr Pro Gly Ser Asn Gly Phe Gly Phe Asp Val Pro 
            20                  25                  30          


Pro Gln Pro Pro Phe Gln Ala Ala Thr His Leu Glu Gly Asp Tyr Gln 
        35                  40                  45              


Arg Ser Ala Cys Ser Leu Gln Ser Leu Gly Asn Ala Ala Pro His Ala 
    50                  55                  60                  


Lys Ser Lys Glu Leu Asn Gly Ser Cys Met Arg Pro Gly Leu Ala Pro 
65                  70                  75                  80  


Glu Pro Leu Ser Ala Pro Pro Gly Ser Pro Pro Pro Ser Ala Ala Pro 
                85                  90                  95      


Thr Ser Ala Thr Ser Asn Ser Ser Asn Gly Gly Gly Pro Ser Lys Ser 
            100                 105                 110         


Gly Pro Pro Lys Cys Gly Pro Gly Thr Asn Ser Thr Leu Thr Lys Gln 
        115                 120                 125             


Ile Phe Pro Trp Met Lys Glu Ser Arg Gln Thr Ser Lys Leu Lys Asn 
    130                 135                 140                 


Asn Ser Pro Gly Thr Ala Glu Gly Cys Gly Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Gly Gly Asp Lys Ser Pro Pro Gly Ser Ala Ala Ser Lys Arg Ala Arg 
            180                 185                 190         


Thr Ala Tyr Thr Ser Ala Gln Leu Val Glu Leu Glu Lys Glu Phe His 
        195                 200                 205             


Phe Asn Arg Tyr Leu Cys Arg Pro Arg Arg Val Glu Met Ala Asn Leu 
    210                 215                 220                 


Leu Asn Leu Ser Glu Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg 
225                 230                 235                 240 


Met Lys Tyr Lys Lys Asp Gln Lys Ala Lys Gly Leu Ala Ser Ser Ser 
                245                 250                 255     


Gly Gly Pro Ser Pro Ala Gly Ser Pro Pro Gln Pro Met Gln Ser Thr 
            260                 265                 270         


Ala Gly Phe Met Asn Ala Leu His Ser Met Thr Pro Ser Tyr Glu Ser 
        275                 280                 285             


Pro Ser Pro Pro Ala Phe Gly Lys Ala His Gln Asn Ala Tyr Ala Leu 
    290                 295                 300                 


Pro Ser Asn Tyr Gln Pro Pro Leu Lys Gly Cys Gly Ala Pro Gln Lys 
305                 310                 315                 320 


Tyr Pro Pro Thr Pro Ala Pro Glu Tyr Glu Pro His Val Leu Gln Ala 
                325                 330                 335     


Asn Gly Gly Ala Tyr Gly Thr Pro Thr Met Gln Gly Ser Pro Val Tyr 
            340                 345                 350         


Val Gly Gly Gly Gly Tyr Ala Asp Pro Leu Pro Pro Pro Ala Gly Pro 
        355                 360                 365             


Ser Leu Tyr Gly Leu Asn His Leu Ser His His Pro Ser Gly Asn Leu 
    370                 375                 380                 


Asp Tyr Asn Gly Ala Pro Pro Met Ala Pro Ser Gln His His Gly Pro 
385                 390                 395                 400 


Cys Glu Pro His Pro Thr Tyr Thr Asp Leu Ser Ser His His Ala Pro 
                405                 410                 415     


Pro Pro Gln Gly Arg Ile Gln Glu Ala Pro Lys Leu Thr His Leu 
            420                 425                 430     


<210>  59
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Ser Ser Tyr Phe Val Asn Ser Phe Ser Gly Arg Tyr Pro Asn Gly 
1               5                   10                  15      


Pro Asp Tyr Gln Leu Leu Asn Tyr Gly Ser Gly Ser Ser Leu Ser Gly 
            20                  25                  30          


Ser Tyr Arg Asp Pro Ala Ala Met His Thr Gly Ser Tyr Gly Tyr Asn 
        35                  40                  45              


Tyr Asn Gly Met Asp Leu Ser Val Asn Arg Ser Ser Ala Ser Ser Ser 
    50                  55                  60                  


His Phe Gly Ala Val Gly Glu Ser Ser Arg Ala Phe Pro Ala Pro Ala 
65                  70                  75                  80  


Gln Glu Pro Arg Phe Arg Gln Ala Ala Ser Ser Cys Ser Leu Ser Ser 
                85                  90                  95      


Pro Glu Ser Leu Pro Cys Thr Asn Gly Asp Ser His Gly Ala Lys Pro 
            100                 105                 110         


Ser Ala Ser Ser Pro Ser Asp Gln Ala Thr Ser Ala Ser Ser Ser Ala 
        115                 120                 125             


Asn Phe Thr Glu Ile Asp Glu Ala Ser Ala Ser Ser Glu Pro Glu Glu 
    130                 135                 140                 


Ala Ala Ser Gln Leu Ser Ser Pro Ser Leu Ala Arg Ala Gln Pro Glu 
145                 150                 155                 160 


Pro Met Ala Thr Ser Thr Ala Ala Pro Glu Gly Gln Thr Pro Gln Ile 
                165                 170                 175     


Phe Pro Trp Met Arg Lys Leu His Ile Ser His Asp Met Thr Gly Pro 
            180                 185                 190         


Asp Gly Lys Arg Ala Arg Thr Ala Tyr Thr Arg Tyr Gln Thr Leu Glu 
        195                 200                 205             


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
    210                 215                 220                 


Ile Glu Ile Ala His Ala Leu Cys Leu Ser Glu Arg Gln Ile Lys Ile 
225                 230                 235                 240 


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Asp Asn Lys Leu Lys 
                245                 250                 255     


Ser Met Ser Leu Ala Thr Ala Gly Ser Ala Phe Gln Pro 
            260                 265                 


<210>  60
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ser Ser Tyr Phe Val Asn Ser Thr Phe Pro Val Thr Leu Ala Ser 
1               5                   10                  15      


Gly Gln Glu Ser Phe Leu Gly Gln Leu Pro Leu Tyr Ser Ser Gly Tyr 
            20                  25                  30          


Ala Asp Pro Leu Arg His Tyr Pro Ala Pro Tyr Gly Pro Gly Pro Gly 
        35                  40                  45              


Gln Asp Lys Gly Phe Ala Thr Ser Ser Tyr Tyr Pro Pro Ala Gly Gly 
    50                  55                  60                  


Gly Tyr Gly Arg Ala Ala Pro Cys Asp Tyr Gly Pro Ala Pro Ala Phe 
65                  70                  75                  80  


Tyr Arg Glu Lys Glu Ser Ala Cys Ala Leu Ser Gly Ala Asp Glu Gln 
                85                  90                  95      


Pro Pro Phe His Pro Glu Pro Arg Lys Ser Asp Cys Ala Gln Asp Lys 
            100                 105                 110         


Ser Val Phe Gly Glu Thr Glu Glu Gln Lys Cys Ser Thr Pro Val Tyr 
        115                 120                 125             


Pro Trp Met Gln Arg Met Asn Ser Cys Asn Ser Ser Ser Phe Gly Pro 
    130                 135                 140                 


Ser Gly Arg Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe His Tyr Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
                165                 170                 175     


Ile Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Ser Lys Leu Leu 
        195                 200                 205             


Ser Ala Ser Gln Leu Ser Ala Glu Glu Glu Glu Glu Lys Gln Ala Glu 
    210                 215                 220                 


<210>  61
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ala Ala Ala Gly Gln Leu Cys Leu Leu Tyr Leu Ser Ala Gly Leu 
1               5                   10                  15      


Leu Ser Arg Leu Gly Ala Ala Phe Asn Leu Asp Thr Arg Glu Asp Asn 
            20                  25                  30          


Val Ile Arg Lys Tyr Gly Asp Pro Gly Ser Leu Phe Gly Phe Ser Leu 
        35                  40                  45              


Ala Met His Trp Gln Leu Gln Pro Glu Asp Lys Arg Leu Leu Leu Val 
    50                  55                  60                  


Gly Ala Pro Arg Ala Glu Ala Leu Pro Leu Gln Arg Ala Asn Arg Thr 
65                  70                  75                  80  


Gly Gly Leu Tyr Ser Cys Asp Ile Thr Ala Arg Gly Pro Cys Thr Arg 
                85                  90                  95      


Ile Glu Phe Asp Asn Asp Ala Asp Pro Thr Ser Glu Ser Lys Glu Asp 
            100                 105                 110         


Gln Trp Met Gly Val Thr Val Gln Ser Gln Gly Pro Gly Gly Lys Val 
        115                 120                 125             


Val Thr Cys Ala His Arg Tyr Glu Lys Arg Gln His Val Asn Thr Lys 
    130                 135                 140                 


Gln Glu Ser Arg Asp Ile Phe Gly Arg Cys Tyr Val Leu Ser Gln Asn 
145                 150                 155                 160 


Leu Arg Ile Glu Asp Asp Met Asp Gly Gly Asp Trp Ser Phe Cys Asp 
                165                 170                 175     


Gly Arg Leu Arg Gly His Glu Lys Phe Gly Ser Cys Gln Gln Gly Val 
            180                 185                 190         


Ala Ala Thr Phe Thr Lys Asp Phe His Tyr Ile Val Phe Gly Ala Pro 
        195                 200                 205             


Gly Thr Tyr Asn Trp Lys Gly Ile Val Arg Val Glu Gln Lys Asn Asn 
    210                 215                 220                 


Thr Phe Phe Asp Met Asn Ile Phe Glu Asp Gly Pro Tyr Glu Val Gly 
225                 230                 235                 240 


Gly Glu Thr Glu His Asp Glu Ser Leu Val Pro Val Pro Ala Asn Ser 
                245                 250                 255     


Tyr Leu Gly Phe Ser Leu Asp Ser Gly Lys Gly Ile Val Ser Lys Asp 
            260                 265                 270         


Glu Ile Thr Phe Val Ser Gly Ala Pro Arg Ala Asn His Ser Gly Ala 
        275                 280                 285             


Val Val Leu Leu Lys Arg Asp Met Lys Ser Ala His Leu Leu Pro Glu 
    290                 295                 300                 


His Ile Phe Asp Gly Glu Gly Leu Ala Ser Ser Phe Gly Tyr Asp Val 
305                 310                 315                 320 


Ala Val Val Asp Leu Asn Lys Asp Gly Trp Gln Asp Ile Val Ile Gly 
                325                 330                 335     


Ala Pro Gln Tyr Phe Asp Arg Asp Gly Glu Val Gly Gly Ala Val Tyr 
            340                 345                 350         


Val Tyr Met Asn Gln Gln Gly Arg Trp Asn Asn Val Lys Pro Ile Arg 
        355                 360                 365             


Leu Asn Gly Thr Lys Asp Ser Met Phe Gly Ile Ala Val Lys Asn Ile 
    370                 375                 380                 


Gly Asp Ile Asn Gln Asp Gly Tyr Pro Asp Ile Ala Val Gly Ala Pro 
385                 390                 395                 400 


Tyr Asp Asp Leu Gly Lys Val Phe Ile Tyr His Gly Ser Ala Asn Gly 
                405                 410                 415     


Ile Asn Thr Lys Pro Thr Gln Val Leu Lys Gly Ile Ser Pro Tyr Phe 
            420                 425                 430         


Gly Tyr Ser Ile Ala Gly Asn Met Asp Leu Asp Arg Asn Ser Tyr Pro 
        435                 440                 445             


Asp Val Ala Val Gly Ser Leu Ser Asp Ser Val Thr Ile Phe Arg Ser 
    450                 455                 460                 


Arg Pro Val Ile Asn Ile Gln Lys Thr Ile Thr Val Thr Pro Asn Arg 
465                 470                 475                 480 


Ile Asp Leu Arg Gln Lys Thr Ala Cys Gly Ala Pro Ser Gly Ile Cys 
                485                 490                 495     


Leu Gln Val Lys Ser Cys Phe Glu Tyr Thr Ala Asn Pro Ala Gly Tyr 
            500                 505                 510         


Asn Pro Ser Ile Ser Ile Val Gly Thr Leu Glu Ala Glu Lys Glu Arg 
        515                 520                 525             


Arg Lys Ser Gly Leu Ser Ser Arg Val Gln Phe Arg Asn Gln Gly Ser 
    530                 535                 540                 


Glu Pro Lys Tyr Thr Gln Glu Leu Thr Leu Lys Arg Gln Lys Gln Lys 
545                 550                 555                 560 


Val Cys Met Glu Glu Thr Leu Trp Leu Gln Asp Asn Ile Arg Asp Lys 
                565                 570                 575     


Leu Arg Pro Ile Pro Ile Thr Ala Ser Val Glu Ile Gln Glu Pro Ser 
            580                 585                 590         


Ser Arg Arg Arg Val Asn Ser Leu Pro Glu Val Leu Pro Ile Leu Asn 
        595                 600                 605             


Ser Asp Glu Pro Lys Thr Ala His Ile Asp Val His Phe Leu Lys Glu 
    610                 615                 620                 


Gly Cys Gly Asp Asp Asn Val Cys Asn Ser Asn Leu Lys Leu Glu Tyr 
625                 630                 635                 640 


Lys Phe Cys Thr Arg Glu Gly Asn Gln Asp Lys Phe Ser Tyr Leu Pro 
                645                 650                 655     


Ile Gln Lys Gly Val Pro Glu Leu Val Leu Lys Asp Gln Lys Asp Ile 
            660                 665                 670         


Ala Leu Glu Ile Thr Val Thr Asn Ser Pro Ser Asn Pro Arg Asn Pro 
        675                 680                 685             


Thr Lys Asp Gly Asp Asp Ala His Glu Ala Lys Leu Ile Ala Thr Phe 
    690                 695                 700                 


Pro Asp Thr Leu Thr Tyr Ser Ala Tyr Arg Glu Leu Arg Ala Phe Pro 
705                 710                 715                 720 


Glu Lys Gln Leu Ser Cys Val Ala Asn Gln Asn Gly Ser Gln Ala Asp 
                725                 730                 735     


Cys Glu Leu Gly Asn Pro Phe Lys Arg Asn Ser Asn Val Thr Phe Tyr 
            740                 745                 750         


Leu Val Leu Ser Thr Thr Glu Val Thr Phe Asp Thr Pro Asp Leu Asp 
        755                 760                 765             


Ile Asn Leu Lys Leu Glu Thr Thr Ser Asn Gln Asp Asn Leu Ala Pro 
    770                 775                 780                 


Ile Thr Ala Lys Ala Lys Val Val Ile Glu Leu Leu Leu Ser Val Ser 
785                 790                 795                 800 


Gly Val Ala Lys Pro Ser Gln Val Tyr Phe Gly Gly Thr Val Val Gly 
                805                 810                 815     


Glu Gln Ala Met Lys Ser Glu Asp Glu Val Gly Ser Leu Ile Glu Tyr 
            820                 825                 830         


Glu Phe Arg Val Ile Asn Leu Gly Lys Pro Leu Thr Asn Leu Gly Thr 
        835                 840                 845             


Ala Thr Leu Asn Ile Gln Trp Pro Lys Glu Ile Ser Asn Gly Lys Trp 
    850                 855                 860                 


Leu Leu Tyr Leu Val Lys Val Glu Ser Lys Gly Leu Glu Lys Val Thr 
865                 870                 875                 880 


Cys Glu Pro Gln Lys Glu Ile Asn Ser Leu Asn Leu Thr Glu Ser His 
                885                 890                 895     


Asn Ser Arg Lys Lys Arg Glu Ile Thr Glu Lys Gln Ile Asp Asp Asn 
            900                 905                 910         


Arg Lys Phe Ser Leu Phe Ala Glu Arg Lys Tyr Gln Thr Leu Asn Cys 
        915                 920                 925             


Ser Val Asn Val Asn Cys Val Asn Ile Arg Cys Pro Leu Arg Gly Leu 
    930                 935                 940                 


Asp Ser Lys Ala Ser Leu Ile Leu Arg Ser Arg Leu Trp Asn Ser Thr 
945                 950                 955                 960 


Phe Leu Glu Glu Tyr Ser Lys Leu Asn Tyr Leu Asp Ile Leu Met Arg 
                965                 970                 975     


Ala Phe Ile Asp Val Thr Ala Ala Ala Glu Asn Ile Arg Leu Pro Asn 
            980                 985                 990         


Ala Gly Thr Gln Val Arg Val Thr  Val Phe Pro Ser Lys  Thr Val Ala 
        995                 1000                 1005             


Gln Tyr  Ser Gly Val Pro Trp  Trp Ile Ile Leu Val  Ala Ile Leu 
    1010                 1015                 1020             


Ala Gly  Ile Leu Met Leu Ala  Leu Leu Val Phe Ile  Leu Trp Lys 
    1025                 1030                 1035             


Cys Gly  Phe Phe Lys Arg Ser  Arg Tyr Asp Asp Ser  Val Pro Arg 
    1040                 1045                 1050             


Tyr His  Ala Val Arg Ile Arg  Lys Glu Glu Arg Glu  Ile Lys Asp 
    1055                 1060                 1065             


Glu Lys  Tyr Ile Asp Asn Leu  Glu Lys Lys Gln Trp  Ile Thr Lys 
    1070                 1075                 1080             


Trp Asn  Glu Asn Glu Ser Tyr  Ser 
    1085                 1090     


<210>  62
<211>  976
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Arg Gly Ala Arg Gly Ala Trp Asp Phe Leu Cys Val Leu Leu Leu 
1               5                   10                  15      


Leu Leu Arg Val Gln Thr Gly Ser Ser Gln Pro Ser Val Ser Pro Gly 
            20                  25                  30          


Glu Pro Ser Pro Pro Ser Ile His Pro Gly Lys Ser Asp Leu Ile Val 
        35                  40                  45              


Arg Val Gly Asp Glu Ile Arg Leu Leu Cys Thr Asp Pro Gly Phe Val 
    50                  55                  60                  


Lys Trp Thr Phe Glu Ile Leu Asp Glu Thr Asn Glu Asn Lys Gln Asn 
65                  70                  75                  80  


Glu Trp Ile Thr Glu Lys Ala Glu Ala Thr Asn Thr Gly Lys Tyr Thr 
                85                  90                  95      


Cys Thr Asn Lys His Gly Leu Ser Asn Ser Ile Tyr Val Phe Val Arg 
            100                 105                 110         


Asp Pro Ala Lys Leu Phe Leu Val Asp Arg Ser Leu Tyr Gly Lys Glu 
        115                 120                 125             


Asp Asn Asp Thr Leu Val Arg Cys Pro Leu Thr Asp Pro Glu Val Thr 
    130                 135                 140                 


Asn Tyr Ser Leu Lys Gly Cys Gln Gly Lys Pro Leu Pro Lys Asp Leu 
145                 150                 155                 160 


Arg Phe Ile Pro Asp Pro Lys Ala Gly Ile Met Ile Lys Ser Val Lys 
                165                 170                 175     


Arg Ala Tyr His Arg Leu Cys Leu His Cys Ser Val Asp Gln Glu Gly 
            180                 185                 190         


Lys Ser Val Leu Ser Glu Lys Phe Ile Leu Lys Val Arg Pro Ala Phe 
        195                 200                 205             


Lys Ala Val Pro Val Val Ser Val Ser Lys Ala Ser Tyr Leu Leu Arg 
    210                 215                 220                 


Glu Gly Glu Glu Phe Thr Val Thr Cys Thr Ile Lys Asp Val Ser Ser 
225                 230                 235                 240 


Ser Val Tyr Ser Thr Trp Lys Arg Glu Asn Ser Gln Thr Lys Leu Gln 
                245                 250                 255     


Glu Lys Tyr Asn Ser Trp His His Gly Asp Phe Asn Tyr Glu Arg Gln 
            260                 265                 270         


Ala Thr Leu Thr Ile Ser Ser Ala Arg Val Asn Asp Ser Gly Val Phe 
        275                 280                 285             


Met Cys Tyr Ala Asn Asn Thr Phe Gly Ser Ala Asn Val Thr Thr Thr 
    290                 295                 300                 


Leu Glu Val Val Asp Lys Gly Phe Ile Asn Ile Phe Pro Met Ile Asn 
305                 310                 315                 320 


Thr Thr Val Phe Val Asn Asp Gly Glu Asn Val Asp Leu Ile Val Glu 
                325                 330                 335     


Tyr Glu Ala Phe Pro Lys Pro Glu His Gln Gln Trp Ile Tyr Met Asn 
            340                 345                 350         


Arg Thr Phe Thr Asp Lys Trp Glu Asp Tyr Pro Lys Ser Glu Asn Glu 
        355                 360                 365             


Ser Asn Ile Arg Tyr Val Ser Glu Leu His Leu Thr Arg Leu Lys Gly 
    370                 375                 380                 


Thr Glu Gly Gly Thr Tyr Thr Phe Leu Val Ser Asn Ser Asp Val Asn 
385                 390                 395                 400 


Ala Ala Ile Ala Phe Asn Val Tyr Val Asn Thr Lys Pro Glu Ile Leu 
                405                 410                 415     


Thr Tyr Asp Arg Leu Val Asn Gly Met Leu Gln Cys Val Ala Ala Gly 
            420                 425                 430         


Phe Pro Glu Pro Thr Ile Asp Trp Tyr Phe Cys Pro Gly Thr Glu Gln 
        435                 440                 445             


Arg Cys Ser Ala Ser Val Leu Pro Val Asp Val Gln Thr Leu Asn Ser 
    450                 455                 460                 


Ser Gly Pro Pro Phe Gly Lys Leu Val Val Gln Ser Ser Ile Asp Ser 
465                 470                 475                 480 


Ser Ala Phe Lys His Asn Gly Thr Val Glu Cys Lys Ala Tyr Asn Asp 
                485                 490                 495     


Val Gly Lys Thr Ser Ala Tyr Phe Asn Phe Ala Phe Lys Gly Asn Asn 
            500                 505                 510         


Lys Glu Gln Ile His Pro His Thr Leu Phe Thr Pro Leu Leu Ile Gly 
        515                 520                 525             


Phe Val Ile Val Ala Gly Met Met Cys Ile Ile Val Met Ile Leu Thr 
    530                 535                 540                 


Tyr Lys Tyr Leu Gln Lys Pro Met Tyr Glu Val Gln Trp Lys Val Val 
545                 550                 555                 560 


Glu Glu Ile Asn Gly Asn Asn Tyr Val Tyr Ile Asp Pro Thr Gln Leu 
                565                 570                 575     


Pro Tyr Asp His Lys Trp Glu Phe Pro Arg Asn Arg Leu Ser Phe Gly 
            580                 585                 590         


Lys Thr Leu Gly Ala Gly Ala Phe Gly Lys Val Val Glu Ala Thr Ala 
        595                 600                 605             


Tyr Gly Leu Ile Lys Ser Asp Ala Ala Met Thr Val Ala Val Lys Met 
    610                 615                 620                 


Leu Lys Pro Ser Ala His Leu Thr Glu Arg Glu Ala Leu Met Ser Glu 
625                 630                 635                 640 


Leu Lys Val Leu Ser Tyr Leu Gly Asn His Met Asn Ile Val Asn Leu 
                645                 650                 655     


Leu Gly Ala Cys Thr Ile Gly Gly Pro Thr Leu Val Ile Thr Glu Tyr 
            660                 665                 670         


Cys Cys Tyr Gly Asp Leu Leu Asn Phe Leu Arg Arg Lys Arg Asp Ser 
        675                 680                 685             


Phe Ile Cys Ser Lys Gln Glu Asp His Ala Glu Ala Ala Leu Tyr Lys 
    690                 695                 700                 


Asn Leu Leu His Ser Lys Glu Ser Ser Cys Ser Asp Ser Thr Asn Glu 
705                 710                 715                 720 


Tyr Met Asp Met Lys Pro Gly Val Ser Tyr Val Val Pro Thr Lys Ala 
                725                 730                 735     


Asp Lys Arg Arg Ser Val Arg Ile Gly Ser Tyr Ile Glu Arg Asp Val 
            740                 745                 750         


Thr Pro Ala Ile Met Glu Asp Asp Glu Leu Ala Leu Asp Leu Glu Asp 
        755                 760                 765             


Leu Leu Ser Phe Ser Tyr Gln Val Ala Lys Gly Met Ala Phe Leu Ala 
    770                 775                 780                 


Ser Lys Asn Cys Ile His Arg Asp Leu Ala Ala Arg Asn Ile Leu Leu 
785                 790                 795                 800 


Thr His Gly Arg Ile Thr Lys Ile Cys Asp Phe Gly Leu Ala Arg Asp 
                805                 810                 815     


Ile Lys Asn Asp Ser Asn Tyr Val Val Lys Gly Asn Ala Arg Leu Pro 
            820                 825                 830         


Val Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Cys Val Tyr Thr Phe 
        835                 840                 845             


Glu Ser Asp Val Trp Ser Tyr Gly Ile Phe Leu Trp Glu Leu Phe Ser 
    850                 855                 860                 


Leu Gly Ser Ser Pro Tyr Pro Gly Met Pro Val Asp Ser Lys Phe Tyr 
865                 870                 875                 880 


Lys Met Ile Lys Glu Gly Phe Arg Met Leu Ser Pro Glu His Ala Pro 
                885                 890                 895     


Ala Glu Met Tyr Asp Ile Met Lys Thr Cys Trp Asp Ala Asp Pro Leu 
            900                 905                 910         


Lys Arg Pro Thr Phe Lys Gln Ile Val Gln Leu Ile Glu Lys Gln Ile 
        915                 920                 925             


Ser Glu Ser Thr Asn His Ile Tyr Ser Asn Leu Ala Asn Cys Ser Pro 
    930                 935                 940                 


Asn Arg Gln Lys Pro Val Val Asp His Ser Val Arg Ile Asn Ser Val 
945                 950                 955                 960 


Gly Ser Thr Ala Ser Ser Ser Gln Pro Leu Leu Val His Asp Asp Val 
                965                 970                 975     


<210>  63
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Ala Gln Arg Tyr Asp Asp Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Ile Pro Ser Thr Met Tyr Gly Asp Pro His Ala Ala Arg Ser 
            20                  25                  30          


Met Gln Pro Val His His Leu Asn His Gly Pro Pro Leu His Ser His 
        35                  40                  45              


Gln Tyr Pro His Thr Ala His Thr Asn Ala Met Ala Pro Ser Met Gly 
    50                  55                  60                  


Ser Ser Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile Tyr Gly 
65                  70                  75                  80  


His Pro Leu Phe Pro Leu Leu Ala Leu Ile Phe Glu Lys Cys Glu Leu 
                85                  90                  95      


Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp Val Cys 
            100                 105                 110         


Ser Ser Glu Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys Gln Ile 
        115                 120                 125             


Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu 
    130                 135                 140                 


Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu Leu Glu 
145                 150                 155                 160 


Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile Ser Cys 
                165                 170                 175     


Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Asp Arg Glu Gly 
            180                 185                 190         


Gly Ser Lys Ser Asp Ser Glu Asp Ile Thr Arg Ser Ala Asn Leu Thr 
        195                 200                 205             


Asp Gln Pro Ser Trp Asn Arg Asp His Asp Asp Thr Ala Ser Thr Arg 
    210                 215                 220                 


Ser Gly Gly Thr Pro Gly Pro Ser Ser Gly Gly His Thr Ser His Ser 
225                 230                 235                 240 


Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala 
                245                 250                 255     


Ser Pro Ser Thr Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg 
            260                 265                 270         


His Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg 
        275                 280                 285             


Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln 
    290                 295                 300                 


Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn 
305                 310                 315                 320 


Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp 
                325                 330                 335     


Gln Ser Asn Arg Ala Val Ser Gln Gly Thr Pro Tyr Asn Pro Asp Gly 
            340                 345                 350         


Gln Pro Met Gly Gly Phe Val Met Asp Gly Gln Gln His Met Gly Ile 
        355                 360                 365             


Arg Ala Pro Gly Pro Met Ser Gly Met Gly Met Asn Met Gly Met Glu 
    370                 375                 380                 


Gly Gln Trp His Tyr Met 
385                 390 


<210>  64
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Pro Ser Cys Ser Thr Ser Thr Met Pro Gly Met Ile Cys Lys Asn 
1               5                   10                  15      


Pro Asp Leu Glu Phe Asp Ser Leu Gln Pro Cys Phe Tyr Pro Asp Glu 
            20                  25                  30          


Asp Asp Phe Tyr Phe Gly Gly Pro Asp Ser Thr Pro Pro Gly Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Gly Phe Ala Glu His Ser Ser Glu Pro Pro Ser Trp Val Thr Glu 
65                  70                  75                  80  


Met Leu Leu Glu Asn Glu Leu Trp Gly Ser Pro Ala Glu Glu Asp Ala 
                85                  90                  95      


Phe Gly Leu Gly Gly Leu Gly Gly Leu Thr Pro Asn Pro Val Ile Leu 
            100                 105                 110         


Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Arg Glu Lys Leu Glu Arg 
        115                 120                 125             


Ala Val Ser Glu Lys Leu Gln His Gly Arg Gly Pro Pro Thr Ala Gly 
    130                 135                 140                 


Ser Thr Ala Gln Ser Pro Gly Ala Gly Ala Ala Ser Pro Ala Gly Arg 
145                 150                 155                 160 


Gly His Gly Gly Ala Ala Gly Ala Gly Arg Ala Gly Ala Ala Leu Pro 
                165                 170                 175     


Ala Glu Leu Ala His Pro Ala Ala Glu Cys Val Asp Pro Ala Val Val 
            180                 185                 190         


Phe Pro Phe Pro Val Asn Lys Arg Glu Pro Ala Pro Val Pro Ala Ala 
        195                 200                 205             


Pro Ala Ser Ala Pro Ala Ala Gly Pro Ala Val Ala Ser Gly Ala Gly 
    210                 215                 220                 


Ile Ala Ala Pro Ala Gly Ala Pro Gly Val Ala Pro Pro Arg Pro Gly 
225                 230                 235                 240 


Gly Arg Gln Thr Ser Gly Gly Asp His Lys Ala Leu Ser Thr Ser Gly 
                245                 250                 255     


Glu Asp Thr Leu Ser Asp Ser Asp Asp Glu Asp Asp Glu Glu Glu Asp 
            260                 265                 270         


Glu Glu Glu Glu Ile Asp Val Val Thr Val Glu Lys Arg Arg Ser Ser 
        275                 280                 285             


Ser Asn Thr Lys Ala Val Thr Thr Phe Thr Ile Thr Val Arg Pro Lys 
    290                 295                 300                 


Asn Ala Ala Leu Gly Pro Gly Arg Ala Gln Ser Ser Glu Leu Ile Leu 
305                 310                 315                 320 


Lys Arg Cys Leu Pro Ile His Gln Gln His Asn Tyr Ala Ala Pro Ser 
                325                 330                 335     


Pro Tyr Val Glu Ser Glu Asp Ala Pro Pro Gln Lys Lys Ile Lys Ser 
            340                 345                 350         


Glu Ala Ser Pro Arg Pro Leu Lys Ser Val Ile Pro Pro Lys Ala Lys 
        355                 360                 365             


Ser Leu Ser Pro Arg Asn Ser Asp Ser Glu Asp Ser Glu Arg Arg Arg 
    370                 375                 380                 


Asn His Asn Ile Leu Glu Arg Gln Arg Arg Asn Asp Leu Arg Ser Ser 
385                 390                 395                 400 


Phe Leu Thr Leu Arg Asp His Val Pro Glu Leu Val Lys Asn Glu Lys 
                405                 410                 415     


Ala Ala Lys Val Val Ile Leu Lys Lys Ala Thr Glu Tyr Val His Ser 
            420                 425                 430         


Leu Gln Ala Glu Glu His Gln Leu Leu Leu Glu Lys Glu Lys Leu Gln 
        435                 440                 445             


Ala Arg Gln Gln Gln Leu Leu Lys Lys Ile Glu His Ala Arg Thr Cys 
    450                 455                 460                 


<210>  65
<211>  462
<212>  PRT
<213>  Homo sapiens

<400>  65

Met Gln Leu Arg Lys Met Gln Thr Val Lys Lys Glu Gln Ala Ser Leu 
1               5                   10                  15      


Asp Ala Ser Ser Asn Val Asp Lys Met Met Val Leu Asn Ser Ala Leu 
            20                  25                  30          


Thr Glu Val Ser Glu Asp Ser Thr Thr Gly Glu Glu Leu Leu Leu Ser 
        35                  40                  45              


Glu Gly Ser Val Gly Lys Asn Lys Ser Ser Ala Cys Arg Arg Lys Arg 
    50                  55                  60                  


Glu Phe Ile Pro Asp Glu Lys Lys Asp Ala Met Tyr Trp Glu Lys Arg 
65                  70                  75                  80  


Arg Lys Asn Asn Glu Ala Ala Lys Arg Ser Arg Glu Lys Arg Arg Leu 
                85                  90                  95      


Asn Asp Leu Val Leu Glu Asn Lys Leu Ile Ala Leu Gly Glu Glu Asn 
            100                 105                 110         


Ala Thr Leu Lys Ala Glu Leu Leu Ser Leu Lys Leu Lys Phe Gly Leu 
        115                 120                 125             


Ile Ser Ser Thr Ala Tyr Ala Gln Glu Ile Gln Lys Leu Ser Asn Ser 
    130                 135                 140                 


Thr Ala Val Tyr Phe Gln Asp Tyr Gln Thr Ser Lys Ser Asn Val Ser 
145                 150                 155                 160 


Ser Phe Val Asp Glu His Glu Pro Ser Met Val Ser Ser Ser Cys Ile 
                165                 170                 175     


Ser Val Ile Lys His Ser Pro Gln Ser Ser Leu Ser Asp Val Ser Glu 
            180                 185                 190         


Val Ser Ser Val Glu His Thr Gln Glu Ser Ser Val Gln Gly Ser Cys 
        195                 200                 205             


Arg Ser Pro Glu Asn Lys Phe Gln Ile Ile Lys Gln Glu Pro Met Glu 
    210                 215                 220                 


Leu Glu Ser Tyr Thr Arg Glu Pro Arg Asp Asp Arg Gly Ser Tyr Thr 
225                 230                 235                 240 


Ala Ser Ile Tyr Gln Asn Tyr Met Gly Asn Ser Phe Ser Gly Tyr Ser 
                245                 250                 255     


His Ser Pro Pro Leu Leu Gln Val Asn Arg Ser Ser Ser Asn Ser Pro 
            260                 265                 270         


Arg Thr Ser Glu Thr Asp Asp Gly Val Val Gly Lys Ser Ser Asp Gly 
        275                 280                 285             


Glu Asp Glu Gln Gln Val Pro Lys Gly Pro Ile His Ser Pro Val Glu 
    290                 295                 300                 


Leu Lys His Val His Ala Thr Val Val Lys Val Pro Glu Val Asn Ser 
305                 310                 315                 320 


Ser Ala Leu Pro His Lys Leu Arg Ile Lys Ala Lys Ala Met Gln Ile 
                325                 330                 335     


Lys Val Glu Ala Phe Asp Asn Glu Phe Glu Ala Thr Gln Lys Leu Ser 
            340                 345                 350         


Ser Pro Ile Asp Met Thr Ser Lys Arg His Phe Glu Leu Glu Lys His 
        355                 360                 365             


Ser Ala Pro Ser Met Val His Ser Ser Leu Thr Pro Phe Ser Val Gln 
    370                 375                 380                 


Val Thr Asn Ile Gln Asp Trp Ser Leu Lys Ser Glu His Trp His Gln 
385                 390                 395                 400 


Lys Glu Leu Ser Gly Lys Thr Gln Asn Ser Phe Lys Thr Gly Val Val 
                405                 410                 415     


Glu Met Lys Asp Ser Gly Tyr Lys Val Ser Asp Pro Glu Asn Leu Tyr 
            420                 425                 430         


Leu Lys Gln Gly Ile Ala Asn Leu Ser Ala Glu Val Val Ser Leu Lys 
        435                 440                 445             


Arg Leu Ile Ala Thr Gln Pro Ile Ser Ala Ser Asp Ser Gly 
    450                 455                 460         


<210>  66
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Pro Phe Gly Leu Lys Leu Arg Arg Thr Arg Arg Tyr Asn Val Leu 
1               5                   10                  15      


Ser Lys Asn Cys Phe Val Thr Arg Ile Arg Leu Leu Asp Ser Asn Val 
            20                  25                  30          


Ile Glu Cys Thr Leu Ser Val Glu Ser Thr Gly Gln Glu Cys Leu Glu 
        35                  40                  45              


Ala Val Ala Gln Arg Leu Glu Leu Arg Glu Thr His Tyr Phe Gly Leu 
    50                  55                  60                  


Trp Phe Leu Ser Lys Ser Gln Gln Ala Arg Trp Val Glu Leu Glu Lys 
65                  70                  75                  80  


Pro Leu Lys Lys His Leu Asp Lys Phe Ala Asn Glu Pro Leu Leu Phe 
                85                  90                  95      


Phe Gly Val Met Phe Tyr Val Pro Asn Val Ser Trp Leu Gln Gln Glu 
            100                 105                 110         


Ala Thr Arg Tyr Gln Tyr Tyr Leu Gln Val Lys Lys Asp Val Leu Glu 
        115                 120                 125             


Gly Arg Leu Arg Cys Thr Leu Asp Gln Val Ile Arg Leu Ala Gly Leu 
    130                 135                 140                 


Ala Val Gln Ala Asp Phe Gly Asp Tyr Asn Gln Phe Asp Ser Gln Asp 
145                 150                 155                 160 


Phe Leu Arg Glu Tyr Val Leu Phe Pro Met Asp Leu Ala Leu Glu Glu 
                165                 170                 175     


Ala Val Leu Glu Glu Leu Thr Gln Lys Val Ala Gln Glu His Lys Ala 
            180                 185                 190         


His Ser Gly Ile Leu Pro Ala Glu Ala Glu Leu Met Tyr Ile Asn Glu 
        195                 200                 205             


Val Glu Arg Leu Asp Gly Phe Gly Gln Glu Ile Phe Pro Val Lys Asp 
    210                 215                 220                 


Asn His Gly Asn Cys Val His Leu Gly Ile Phe Phe Met Gly Ile Phe 
225                 230                 235                 240 


Val Arg Asn Arg Ile Gly Arg Gln Ala Val Ile Tyr Arg Trp Asn Asp 
                245                 250                 255     


Met Gly Asn Ile Thr His Asn Lys Ser Thr Ile Leu Val Glu Leu Ile 
            260                 265                 270         


Asn Lys Glu Glu Thr Ala Leu Phe His Thr Asp Asp Ile Glu Asn Ala 
        275                 280                 285             


Lys Tyr Ile Ser Arg Leu Phe Ala Thr Arg His Lys Phe Tyr Lys Gln 
    290                 295                 300                 


Asn Lys Ile Cys Thr Glu Gln Ser Asn Ser Pro Pro Pro Ile Arg Arg 
305                 310                 315                 320 


Gln Pro Thr Trp Ser Arg Ser Ser Leu Pro Arg Gln Gln Pro Tyr Ile 
                325                 330                 335     


Leu Pro Pro Val His Val Gln Cys Gly Glu His Tyr Ser Glu Thr His 
            340                 345                 350         


Thr Ser Gln Asp Ser Ile Phe His Gly Asn Glu Glu Ala Leu Tyr Cys 
        355                 360                 365             


Asn Ser His Asn Ser Leu Asp Leu Asn Tyr Leu Asn Gly Thr Val Thr 
    370                 375                 380                 


Asn Gly Ser Val Cys Ser Val His Ser Val Asn Ser Leu Asn Cys Ser 
385                 390                 395                 400 


Gln Ser Phe Ile Gln Ala Ser Pro Val Ser Ser Asn Leu Ser Ile Pro 
                405                 410                 415     


Gly Ser Asp Ile Met Arg Ala Asp Tyr Ile Pro Ser His Arg His Ser 
            420                 425                 430         


Ala Ile Ile Val Pro Ser Tyr Arg Pro Thr Pro Asp Tyr Glu Thr Val 
        435                 440                 445             


Met Arg Gln Met Lys Arg Gly Ile Leu His Thr Asp Ser Gln Ser Gln 
    450                 455                 460                 


Ser Leu Arg Asn Leu Asn Ile Ile Asn Thr His Ala Tyr Asn Gln Pro 
465                 470                 475                 480 


Glu Asp Leu Val Tyr Ser Gln Pro Glu Met Arg Glu Arg His Pro Tyr 
                485                 490                 495     


Thr Val Pro Tyr Gly Pro Gln Gly Val Tyr Ser Asn Lys Leu Val Ser 
            500                 505                 510         


Pro Ser Asp Gln Arg Asn Pro Lys Asn Asn Val Val Pro Ser Lys Pro 
        515                 520                 525             


Gly Ala Ser Ala Ile Ser His Thr Val Ser Thr Pro Glu Leu Ala Asn 
    530                 535                 540                 


Met Gln Leu Gln Gly Ser His Asn Tyr Ser Thr Ala His Met Leu Lys 
545                 550                 555                 560 


Asn Tyr Leu Phe Arg Pro Pro Pro Pro Tyr Pro Arg Pro Arg Pro Ala 
                565                 570                 575     


Thr Ser Thr Pro Asp Leu Ala Ser His Arg His Lys Tyr Val Ser Gly 
            580                 585                 590         


Ser Ser Pro Asp Leu Val Thr Arg Lys Val Gln Leu Ser Val Lys Thr 
        595                 600                 605             


Phe Gln Glu Asp Ser Ser Pro Val Val His Gln Ser Leu Gln Glu Val 
    610                 615                 620                 


Ser Glu Pro Leu Thr Ala Thr Lys His His Gly Thr Val Asn Lys Arg 
625                 630                 635                 640 


His Ser Leu Glu Val Met Asn Ser Met Val Arg Gly Met Glu Ala Met 
                645                 650                 655     


Thr Leu Lys Ser Leu His Leu Pro Met Ala Arg Arg Asn Thr Leu Arg 
            660                 665                 670         


Glu Gln Gly Pro Pro Glu Glu Gly Ser Gly Ser His Glu Val Pro Gln 
        675                 680                 685             


Leu Pro Gln Tyr His His Lys Lys Thr Phe Ser Asp Ala Thr Met Leu 
    690                 695                 700                 


Ile His Ser Ser Glu Ser Glu Glu Glu Glu Glu Glu Ala Pro Glu Ser 
705                 710                 715                 720 


Val Pro Gln Ile Pro Met Leu Arg Glu Lys Met Glu Tyr Ser Ala Gln 
                725                 730                 735     


Leu Gln Ala Ala Leu Ala Arg Ile Pro Asn Lys Pro Pro Pro Glu Tyr 
            740                 745                 750         


Pro Gly Pro Arg Lys Ser Val Ser Asn Gly Ala Leu Arg Gln Asp Gln 
        755                 760                 765             


Ala Ser Leu Pro Pro Ala Met Ala Arg Ala Arg Val Leu Arg His Gly 
    770                 775                 780                 


Pro Ala Lys Ala Ile Ser Met Ser Arg Thr Asp Pro Pro Ala Val Asn 
785                 790                 795                 800 


Gly Ala Ser Leu Gly Pro Ser Ile Ser Glu Pro Asp Leu Thr Ser Val 
                805                 810                 815     


Lys Glu Arg Val Lys Lys Glu Pro Val Lys Glu Arg Pro Val Ser Glu 
            820                 825                 830         


Met Phe Ser Leu Glu Asp Ser Ile Ile Glu Arg Glu Met Met Ile Arg 
        835                 840                 845             


Asn Leu Glu Lys Gln Lys Met Ala Gly Leu Glu Ala Gln Lys Arg Pro 
    850                 855                 860                 


Leu Met Leu Ala Ala Leu Asn Gly Leu Ser Val Ala Arg Val Ser Gly 
865                 870                 875                 880 


Arg Glu Glu Asn Arg Val Asp Ala Thr Arg Val Pro Met Asp Glu Arg 
                885                 890                 895     


Phe Arg Thr Leu Lys Lys Lys Leu Glu Glu Gly Met Val Phe Thr Glu 
            900                 905                 910         


Tyr Glu Gln Ile Pro Lys Lys Lys Ala Asn Gly Ile Phe Ser Thr Ala 
        915                 920                 925             


Ala Leu Pro Glu Asn Ala Glu Arg Ser Arg Ile Arg Glu Val Val Pro 
    930                 935                 940                 


Tyr Glu Glu Asn Arg Val Glu Leu Ile Pro Thr Lys Glu Asn Asn Thr 
945                 950                 955                 960 


Gly Tyr Ile Asn Ala Ser His Ile Lys Val Val Val Gly Gly Ala Glu 
                965                 970                 975     


Trp His Tyr Ile Ala Thr Gln Gly Pro Leu Pro His Thr Cys His Asp 
            980                 985                 990         


Phe Trp Gln Met Val Trp Glu Gln  Gly Val Asn Val Ile  Ala Met Val 
        995                 1000                 1005             


Thr Ala  Glu Glu Glu Gly Gly  Arg Thr Lys Ser His  Arg Tyr Trp 
    1010                 1015                 1020             


Pro Lys  Leu Gly Ser Lys His  Ser Ser Ala Thr Tyr  Gly Lys Phe 
    1025                 1030                 1035             


Lys Val  Thr Thr Lys Phe Arg  Thr Asp Ser Val Cys  Tyr Ala Thr 
    1040                 1045                 1050             


Thr Gly  Leu Lys Val Lys His  Leu Leu Ser Gly Gln  Glu Arg Thr 
    1055                 1060                 1065             


Val Trp  His Leu Gln Tyr Thr  Asp Trp Pro Asp His  Gly Cys Pro 
    1070                 1075                 1080             


Glu Asp  Val Gln Gly Phe Leu  Ser Tyr Leu Glu Glu  Ile Gln Ser 
    1085                 1090                 1095             


Val Arg  Arg His Thr Asn Ser  Met Leu Glu Gly Thr  Lys Asn Arg 
    1100                 1105                 1110             


His Pro  Pro Ile Val Val His  Cys Ser Ala Gly Val  Gly Arg Thr 
    1115                 1120                 1125             


Gly Val  Leu Ile Leu Ser Glu  Leu Met Ile Tyr Cys  Leu Glu His 
    1130                 1135                 1140             


Asn Glu  Lys Val Glu Val Pro  Met Met Leu Arg Leu  Leu Arg Glu 
    1145                 1150                 1155             


Gln Arg  Met Phe Met Ile Gln  Thr Ile Ala Gln Tyr  Lys Phe Val 
    1160                 1165                 1170             


Tyr Gln  Val Leu Ile Gln Phe  Leu Gln Asn Ser Arg  Leu Ile 
    1175                 1180                 1185         


<210>  67
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Ala Ile Arg Lys Lys Leu Val Ile Val Gly Asp Gly Ala Cys 
1               5                   10                  15      


Gly Lys Thr Cys Leu Leu Ile Val Phe Ser Lys Asp Gln Phe Pro Glu 
            20                  25                  30          


Val Tyr Val Pro Thr Val Phe Glu Asn Tyr Ile Ala Asp Ile Glu Val 
        35                  40                  45              


Asp Gly Lys Gln Val Glu Leu Ala Leu Trp Asp Thr Ala Gly Gln Glu 
    50                  55                  60                  


Asp Tyr Asp Arg Leu Arg Pro Leu Ser Tyr Pro Asp Thr Asp Val Ile 
65                  70                  75                  80  


Leu Met Cys Phe Ser Ile Asp Ser Pro Asp Ser Leu Glu Asn Ile Pro 
                85                  90                  95      


Glu Lys Trp Thr Pro Glu Val Lys His Phe Cys Pro Asn Val Pro Ile 
            100                 105                 110         


Ile Leu Val Gly Asn Lys Lys Asp Leu Arg Gln Asp Glu His Thr Arg 
        115                 120                 125             


Arg Glu Leu Ala Lys Met Lys Gln Glu Pro Val Arg Ser Glu Glu Gly 
    130                 135                 140                 


Arg Asp Met Ala Asn Arg Ile Ser Ala Phe Gly Tyr Leu Glu Cys Ser 
145                 150                 155                 160 


Ala Lys Thr Lys Glu Gly Val Arg Glu Val Phe Glu Met Ala Thr Arg 
                165                 170                 175     


Ala Gly Leu Gln Val Arg Lys Asn Lys Arg Arg Arg Gly Cys Pro Ile 
            180                 185                 190         


Leu 
    


<210>  68
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Gly His His His His His His His His His His Ser Ser Gly His 
1               5                   10                  15      


Ile Glu Gly Arg His Met Arg Arg Val Pro Gly Val Ala Pro Thr Leu 
            20                  25                  30          


Val Arg Ser Ala Ser Glu Thr Ser Glu Lys Arg Pro Phe Met Cys Ala 
        35                  40                  45              


Tyr Pro Gly Cys Asn Lys Arg Tyr Phe Lys Leu Ser His Leu Gln Met 
    50                  55                  60                  


His Ser Arg Lys His Thr Gly Glu Lys Pro Tyr Gln Cys Asp Phe Lys 
65                  70                  75                  80  


Asp Cys Glu Arg Arg Phe Phe Arg Ser Asp Gln Leu Lys Arg His Gln 
                85                  90                  95      


Arg Arg His Thr Gly Val Lys Pro Phe Gln Cys Lys Thr Cys Gln Arg 
            100                 105                 110         


Lys Phe Ser Arg Ser Asp His Leu Lys Thr His Thr Arg Thr His Thr 
        115                 120                 125             


Gly Glu Lys Pro Phe Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe 
    130                 135                 140                 


Ala Arg Ser Asp Glu Leu Val Arg His His Asn Met His Gln Arg Asn 
145                 150                 155                 160 


Met Thr Lys Leu Gln Leu Ala Leu 
                165             


<210>  69
<211>  1158
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Ala Ala Val Arg Gly Ala Pro Leu Leu Ser Cys Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Cys Pro Gly Gly Arg Pro Gln Thr Val Leu Thr Asp Asp 
            20                  25                  30          


Glu Ile Glu Glu Phe Leu Glu Gly Phe Leu Ser Glu Leu Glu Pro Glu 
        35                  40                  45              


Pro Arg Glu Asp Asp Val Glu Ala Pro Pro Pro Pro Glu Pro Thr Pro 
    50                  55                  60                  


Arg Val Arg Lys Ala Gln Ala Gly Gly Lys Pro Gly Lys Arg Pro Gly 
65                  70                  75                  80  


Thr Ala Ala Glu Val Pro Pro Glu Lys Thr Lys Asp Lys Gly Lys Lys 
                85                  90                  95      


Gly Lys Lys Asp Lys Gly Pro Lys Val Pro Lys Glu Ser Leu Glu Gly 
            100                 105                 110         


Ser Pro Arg Pro Pro Lys Lys Gly Lys Glu Lys Pro Pro Lys Ala Thr 
        115                 120                 125             


Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu 
    130                 135                 140                 


Lys Pro Pro Lys Ala Thr Lys Lys Pro Lys Glu Lys Pro Pro Lys Ala 
145                 150                 155                 160 


Thr Lys Lys Pro Pro Ser Gly Lys Arg Pro Pro Ile Leu Ala Pro Ser 
                165                 170                 175     


Glu Thr Leu Glu Trp Pro Leu Pro Pro Pro Pro Ser Pro Gly Pro Glu 
            180                 185                 190         


Glu Leu Pro Gln Glu Gly Gly Ala Pro Leu Ser Asn Asn Trp Gln Asn 
        195                 200                 205             


Pro Gly Glu Glu Thr His Val Glu Ala Arg Glu His Gln Pro Glu Pro 
    210                 215                 220                 


Glu Glu Glu Thr Glu Gln Pro Thr Leu Asp Tyr Asn Asp Gln Ile Glu 
225                 230                 235                 240 


Arg Glu Asp Tyr Glu Asp Phe Glu Tyr Ile Arg Arg Gln Lys Gln Pro 
                245                 250                 255     


Arg Pro Pro Pro Ser Arg Arg Arg Arg Pro Glu Arg Val Trp Pro Glu 
            260                 265                 270         


Pro Pro Glu Glu Lys Ala Pro Ala Pro Ala Pro Glu Glu Arg Ile Glu 
        275                 280                 285             


Pro Pro Val Lys Pro Leu Leu Pro Pro Leu Pro Pro Asp Tyr Gly Asp 
    290                 295                 300                 


Gly Tyr Val Ile Pro Asn Tyr Asp Asp Met Asp Tyr Tyr Phe Gly Pro 
305                 310                 315                 320 


Pro Pro Pro Gln Lys Pro Asp Ala Glu Arg Gln Thr Asp Glu Glu Lys 
                325                 330                 335     


Glu Glu Leu Lys Lys Pro Lys Lys Glu Asp Ser Ser Pro Lys Glu Glu 
            340                 345                 350         


Thr Asp Lys Trp Ala Val Glu Lys Gly Lys Asp His Lys Glu Pro Arg 
        355                 360                 365             


Lys Gly Glu Glu Leu Glu Glu Glu Trp Thr Pro Thr Glu Lys Val Lys 
    370                 375                 380                 


Cys Pro Pro Ile Gly Met Glu Ser His Arg Ile Glu Asp Asn Gln Ile 
385                 390                 395                 400 


Arg Ala Ser Ser Met Leu Arg His Gly Leu Gly Ala Gln Arg Gly Arg 
                405                 410                 415     


Leu Asn Met Gln Thr Gly Ala Thr Glu Asp Asp Tyr Tyr Asp Gly Ala 
            420                 425                 430         


Trp Cys Ala Glu Asp Asp Ala Arg Thr Gln Trp Ile Glu Val Asp Thr 
        435                 440                 445             


Arg Arg Thr Thr Arg Phe Thr Gly Val Ile Thr Gln Gly Arg Asp Ser 
    450                 455                 460                 


Ser Ile His Asp Asp Phe Val Thr Thr Phe Phe Val Gly Phe Ser Asn 
465                 470                 475                 480 


Asp Ser Gln Thr Trp Val Met Tyr Thr Asn Gly Tyr Glu Glu Met Thr 
                485                 490                 495     


Phe His Gly Asn Val Asp Lys Asp Thr Pro Val Leu Ser Glu Leu Pro 
            500                 505                 510         


Glu Pro Val Val Ala Arg Phe Ile Arg Ile Tyr Pro Leu Thr Trp Asn 
        515                 520                 525             


Gly Ser Leu Cys Met Arg Leu Glu Val Leu Gly Cys Ser Val Ala Pro 
    530                 535                 540                 


Val Tyr Ser Tyr Tyr Ala Gln Asn Glu Val Val Ala Thr Asp Asp Leu 
545                 550                 555                 560 


Asp Phe Arg His His Ser Tyr Lys Asp Met Arg Gln Leu Met Lys Val 
                565                 570                 575     


Val Asn Glu Glu Cys Pro Thr Ile Thr Arg Thr Tyr Ser Leu Gly Lys 
            580                 585                 590         


Ser Ser Arg Gly Leu Lys Ile Tyr Ala Met Glu Ile Ser Asp Asn Pro 
        595                 600                 605             


Gly Glu His Glu Leu Gly Glu Pro Glu Phe Arg Tyr Thr Ala Gly Ile 
    610                 615                 620                 


His Gly Asn Glu Val Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln 
625                 630                 635                 640 


Tyr Leu Cys Arg Glu Tyr Arg Asp Gly Asn Pro Arg Val Arg Ser Leu 
                645                 650                 655     


Val Gln Asp Thr Arg Ile His Leu Val Pro Ser Leu Asn Pro Asp Gly 
            660                 665                 670         


Tyr Glu Val Ala Ala Gln Met Gly Ser Glu Phe Gly Asn Trp Ala Leu 
        675                 680                 685             


Gly Leu Trp Thr Glu Glu Gly Phe Asp Ile Phe Glu Asp Phe Pro Asp 
    690                 695                 700                 


Leu Asn Ser Val Leu Trp Gly Ala Glu Glu Arg Lys Trp Val Pro Tyr 
705                 710                 715                 720 


Arg Val Pro Asn Asn Asn Leu Pro Ile Pro Glu Arg Tyr Leu Ser Pro 
                725                 730                 735     


Asp Ala Thr Val Ser Thr Glu Val Arg Ala Ile Ile Ala Trp Met Glu 
            740                 745                 750         


Lys Asn Pro Phe Val Leu Gly Ala Asn Leu Asn Gly Gly Glu Arg Leu 
        755                 760                 765             


Val Ser Tyr Pro Tyr Asp Met Ala Arg Thr Pro Thr Gln Glu Gln Leu 
    770                 775                 780                 


Leu Ala Ala Ala Met Ala Ala Ala Arg Gly Glu Asp Glu Asp Glu Val 
785                 790                 795                 800 


Ser Glu Ala Gln Glu Thr Pro Asp His Ala Ile Phe Arg Trp Leu Ala 
                805                 810                 815     


Ile Ser Phe Ala Ser Ala His Leu Thr Leu Thr Glu Pro Tyr Arg Gly 
            820                 825                 830         


Gly Cys Gln Ala Gln Asp Tyr Thr Gly Gly Met Gly Ile Val Asn Gly 
        835                 840                 845             


Ala Lys Trp Asn Pro Arg Thr Gly Thr Ile Asn Asp Phe Ser Tyr Leu 
    850                 855                 860                 


His Thr Asn Cys Leu Glu Leu Ser Phe Tyr Leu Gly Cys Asp Lys Phe 
865                 870                 875                 880 


Pro His Glu Ser Glu Leu Pro Arg Glu Trp Glu Asn Asn Lys Glu Ala 
                885                 890                 895     


Leu Leu Thr Phe Met Glu Gln Val His Arg Gly Ile Lys Gly Val Val 
            900                 905                 910         


Thr Asp Glu Gln Gly Ile Pro Ile Ala Asn Ala Thr Ile Ser Val Ser 
        915                 920                 925             


Gly Ile Asn His Gly Val Lys Thr Ala Ser Gly Gly Asp Tyr Trp Arg 
    930                 935                 940                 


Ile Leu Asn Pro Gly Glu Tyr Arg Val Thr Ala His Ala Glu Gly Tyr 
945                 950                 955                 960 


Thr Pro Ser Ala Lys Thr Cys Asn Val Asp Tyr Asp Ile Gly Ala Thr 
                965                 970                 975     


Gln Cys Asn Phe Ile Leu Ala Arg Ser Asn Trp Lys Arg Ile Arg Glu 
            980                 985                 990         


Ile Met Ala Met Asn Gly Asn Arg  Pro Ile Pro His Ile  Asp Pro Ser 
        995                 1000                 1005             


Arg Pro  Met Thr Pro Gln Gln  Arg Arg Leu Gln Gln  Arg Arg Leu 
    1010                 1015                 1020             


Gln His  Arg Leu Arg Leu Arg  Ala Gln Met Arg Leu  Arg Arg Leu 
    1025                 1030                 1035             


Asn Ala  Thr Thr Thr Leu Gly  Pro His Thr Val Pro  Pro Thr Leu 
    1040                 1045                 1050             


Pro Pro  Ala Pro Ala Thr Thr  Leu Ser Thr Thr Ile  Glu Pro Trp 
    1055                 1060                 1065             


Gly Leu  Ile Pro Pro Thr Thr  Ala Gly Trp Glu Glu  Ser Glu Thr 
    1070                 1075                 1080             


Glu Thr  Tyr Thr Glu Val Val  Thr Glu Phe Gly Thr  Glu Val Glu 
    1085                 1090                 1095             


Pro Glu  Phe Gly Thr Lys Val  Glu Pro Glu Phe Glu  Thr Gln Leu 
    1100                 1105                 1110             


Glu Pro  Glu Phe Glu Thr Gln  Leu Glu Pro Glu Phe  Glu Glu Glu 
    1115                 1120                 1125             


Glu Glu  Glu Glu Lys Glu Glu  Glu Ile Ala Thr Gly  Gln Ala Phe 
    1130                 1135                 1140             


Pro Phe  Thr Thr Val Glu Thr  Tyr Thr Val Asn Phe  Gly Asp Phe 
    1145                 1150                 1155             


<210>  70
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Asn Leu Glu Gln Glu Arg Pro Phe Val Cys Ser Ala Pro Gly Cys 
1               5                   10                  15      


Ser Gln Arg Phe Pro Thr Glu Asp His Leu Met Ile His Arg His Lys 
            20                  25                  30          


His Glu Met Thr Leu Lys Phe Pro Ser Ile Lys Thr Asp Asn Met Leu 
        35                  40                  45              


Ser Asp Gln Thr Pro Thr Pro Thr Arg Phe Leu Lys Asn Cys Glu Glu 
    50                  55                  60                  


Val Gly Leu Phe Ser Glu Leu Asp Cys Ser Leu Glu His Glu Phe Arg 
65                  70                  75                  80  


Lys Ala Gln Glu Glu Glu Ser Ser Lys Arg Asn Ile Ser Met His Asn 
                85                  90                  95      


Ala Val Gly Gly Ala Met Thr Gly Pro Gly Thr His Gln Leu Ser Ser 
            100                 105                 110         


Ala Arg Leu Pro Asn His Asp Thr Asn Val Val Ile Gln Gln Ala Met 
        115                 120                 125             


Pro Ser Pro Gln Ser Ser Ser Val Ile Thr Gln Ala Pro Ser Thr Asn 
    130                 135                 140                 


Arg Gln Ile Gly Pro Val Pro Gly Ser Leu Ser Ser Leu Leu His Leu 
145                 150                 155                 160 


His Asn Arg Gln Arg Gln Pro Met Pro Ala Ser Met Pro Gly Thr Leu 
                165                 170                 175     


Pro Asn Pro Thr Met Pro Gly Ser Ser Ala Val Leu Met Pro Met Glu 
            180                 185                 190         


Arg Gln Met Ser Val Asn Ser Ser Ile Met Gly Met Gln Gly Pro Asn 
        195                 200                 205             


Leu Ser Asn Pro Cys Ala Ser Pro Gln Val Gln Pro Met His Ser Glu 
    210                 215                 220                 


Ala Lys Met Arg Leu Lys Ala Ala Leu Thr His His Pro Ala Ala Met 
225                 230                 235                 240 


Ser Asn Gly Asn Met Asn Thr Met Gly His Met Met Glu Met Met Gly 
                245                 250                 255     


Ser Arg Gln Asp Gln Thr Pro His His His Met His Ser His Pro His 
            260                 265                 270         


Gln His Gln Thr Leu Pro Pro His His Pro Tyr Pro His Gln His Gln 
        275                 280                 285             


His Pro Ala His His Pro His Pro Gln Pro His His Gln Gln Asn His 
    290                 295                 300                 


Pro His His His Ser His Ser His Leu His Ala His Pro Ala His His 
305                 310                 315                 320 


Gln Thr Ser Pro His Pro Pro Leu His Thr Gly Asn Gln Ala Gln Val 
                325                 330                 335     


Ser Pro Ala Thr Gln Gln Met Gln Pro Thr Gln Thr Ile Gln Pro Pro 
            340                 345                 350         


Gln Pro Thr Gly Gly Arg Arg Arg Arg Val Val Asp Glu Asp Pro Asp 
        355                 360                 365             


Glu Arg Arg Arg Lys Phe Leu Glu Arg Asn Arg Ala Ala Ala Thr Arg 
    370                 375                 380                 


Cys Arg Gln Lys Arg Lys Val Trp Val Met Ser Leu Glu Lys Lys Ala 
385                 390                 395                 400 


Glu Glu Leu Thr Gln Thr Asn Met Gln Leu Gln Asn Glu Val Ser Met 
                405                 410                 415     


Leu Lys Asn Glu Val Ala Gln Leu Lys Gln Leu Leu Leu Thr His Lys 
            420                 425                 430         


Asp Cys Pro Ile Thr Ala Met Gln Lys Glu Ser Gln Gly Tyr Leu Ser 
        435                 440                 445             


Pro Glu Ser Ser Pro Pro Ala Ser Pro Val Pro Ala Cys Ser Gln Gln 
    450                 455                 460                 


Gln Val Ile Gln His Asn Thr Ile Thr Thr Ser Ser Ser Val Ser Glu 
465                 470                 475                 480 


Val Val Gly Ser Ser Thr Leu Ser Gln Leu Thr Thr His Arg Thr Asp 
                485                 490                 495     


Leu Asn Pro Ile Leu 
            500     


<210>  71
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Ala Ser Thr Ile Lys Glu Ala Leu Ser Val Val Ser Glu Asp Gln 
1               5                   10                  15      


Ser Leu Phe Glu Cys Ala Tyr Gly Thr Pro His Leu Ala Lys Thr Glu 
            20                  25                  30          


Met Thr Ala Ser Ser Ser Ser Asp Tyr Gly Gln Thr Ser Lys Met Ser 
        35                  40                  45              


Pro Arg Val Pro Gln Gln Asp Trp Leu Ser Gln Pro Pro Ala Arg Val 
    50                  55                  60                  


Thr Ile Lys Met Glu Cys Asn Pro Ser Gln Val Asn Gly Ser Arg Asn 
65                  70                  75                  80  


Ser Pro Asp Glu Cys Ser Val Ala Lys Gly Gly Lys Met Val Gly Ser 
                85                  90                  95      


Pro Asp Thr Val Gly Met Asn Tyr Gly Ser Tyr Met Glu Glu Lys His 
            100                 105                 110         


Met Pro Pro Pro Asn Met Thr Thr Asn Glu Arg Arg Val Ile Val Pro 
        115                 120                 125             


Ala Asp Pro Thr Leu Trp Ser Thr Asp His Val Arg Gln Trp Leu Glu 
    130                 135                 140                 


Trp Ala Val Lys Glu Tyr Gly Leu Pro Asp Val Asn Ile Leu Leu Phe 
145                 150                 155                 160 


Gln Asn Ile Asp Gly Lys Glu Leu Cys Lys Met Thr Lys Asp Asp Phe 
                165                 170                 175     


Gln Arg Leu Thr Pro Ser Tyr Asn Ala Asp Ile Leu Leu Ser His Leu 
            180                 185                 190         


His Tyr Leu Arg Glu Thr Pro Leu Pro His Leu Thr Ser Asp Asp Val 
        195                 200                 205             


Asp Lys Ala Leu Gln Asn Ser Pro Arg Leu Met His Ala Arg Asn Thr 
    210                 215                 220                 


Gly Gly Ala Ala Phe Ile Phe Pro Asn Thr Ser Val Tyr Pro Glu Ala 
225                 230                 235                 240 


Thr Gln Arg Ile Thr Thr Arg Pro Asp Leu Pro Tyr Glu Pro Pro Arg 
                245                 250                 255     


Arg Ser Ala Trp Thr Gly His Gly His Pro Thr Pro Gln Ser Lys Ala 
            260                 265                 270         


Ala Gln Pro Ser Pro Ser Thr Val Pro Lys Thr Glu Asp Gln Arg Pro 
        275                 280                 285             


Gln Leu Asp Pro Tyr Gln Ile Leu Gly Pro Thr Ser Ser Arg Leu Ala 
    290                 295                 300                 


Asn Pro Gly Ser Gly Gln Ile Gln Leu Trp Gln Phe Leu Leu Glu Leu 
305                 310                 315                 320 


Leu Ser Asp Ser Ser Asn Ser Ser Cys Ile Thr Trp Glu Gly Thr Asn 
                325                 330                 335     


Gly Glu Phe Lys Met Thr Asp Pro Asp Glu Val Ala Arg Arg Trp Gly 
            340                 345                 350         


Glu Arg Lys Ser Lys Pro Asn Met Asn Tyr Asp Lys Leu Ser Arg Ala 
        355                 360                 365             


Leu Arg Tyr Tyr Tyr Asp Lys Asn Ile Met Thr Lys Val His Gly Lys 
    370                 375                 380                 


Arg Tyr Ala Tyr Lys Phe Asp Phe His Gly Ile Ala Gln Ala Leu Gln 
385                 390                 395                 400 


Pro His Pro Pro Glu Ser Ser Leu Tyr Lys Tyr Pro Ser Asp Leu Pro 
                405                 410                 415     


Tyr Met Gly Ser Tyr His Ala His Pro Gln Lys Met Asn Phe Val Ala 
            420                 425                 430         


Pro His Pro Pro Ala Leu Pro Val Thr Ser Ser Ser Phe Phe Ala Ala 
        435                 440                 445             


Pro Asn Pro Tyr Trp Asn Ser Pro Thr Gly Gly Ile Tyr Pro Asn Thr 
    450                 455                 460                 


Arg Leu Pro Thr Ser His Met Pro Ser His Leu Gly Thr Tyr Tyr 
465                 470                 475                 


<210>  72
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Tyr Gln Asp Tyr Pro Gly Asn Phe Asp Thr Ser Ser Arg Gly Ser 
1               5                   10                  15      


Ser Gly Ser Pro Ala His Ala Glu Ser Tyr Ser Ser Gly Gly Gly Gly 
            20                  25                  30          


Gln Gln Lys Phe Arg Val Asp Met Pro Gly Ser Gly Ser Ala Phe Ile 
        35                  40                  45              


Pro Thr Ile Asn Ala Ile Thr Thr Ser Gln Asp Leu Gln Trp Met Val 
    50                  55                  60                  


Gln Pro Thr Val Ile Thr Ser Met Ser Asn Pro Tyr Pro Arg Ser His 
65                  70                  75                  80  


Pro Tyr Ser Pro Leu Pro Gly Leu Ala Ser Val Pro Gly His Met Ala 
                85                  90                  95      


Leu Pro Arg Pro Gly Val Ile Lys Thr Ile Gly Thr Thr Val Gly Arg 
            100                 105                 110         


Arg Arg Arg Asp Glu Gln Leu Ser Pro Glu Glu Glu Glu Lys Arg Arg 
        115                 120                 125             


Ile Arg Arg Glu Arg Asn Lys Leu Ala Ala Ala Lys Cys Arg Asn Arg 
    130                 135                 140                 


Arg Arg Glu Leu Thr Glu Lys Leu Gln Ala Glu Thr Glu Glu Leu Glu 
145                 150                 155                 160 


Glu Glu Lys Ser Gly Leu Gln Lys Glu Ile Ala Glu Leu Gln Lys Glu 
                165                 170                 175     


Lys Glu Lys Leu Glu Phe Met Leu Val Ala His Gly Pro Val Cys Lys 
            180                 185                 190         


Ile Ser Pro Glu Glu Arg Arg Ser Pro Pro Ala Pro Gly Leu Gln Pro 
        195                 200                 205             


Met Arg Ser Gly Gly Gly Ser Val Gly Ala Val Val Val Lys Gln Glu 
    210                 215                 220                 


Pro Leu Glu Glu Asp Ser Pro Ser Ser Ser Ser Ala Gly Leu Asp Lys 
225                 230                 235                 240 


Ala Gln Arg Ser Val Ile Lys Pro Ile Ser Ile Ala Gly Gly Phe Tyr 
                245                 250                 255     


Gly Glu Glu Pro Leu His Thr Pro Ile Val Val Thr Ser Thr Pro Ala 
            260                 265                 270         


Val Thr Pro Gly Thr Ser Asn Leu Val Phe Thr Tyr Pro Ser Val Leu 
        275                 280                 285             


Glu Gln Glu Ser Pro Ala Ser Pro Ser Glu Ser Cys Ser Lys Ala His 
    290                 295                 300                 


Arg Arg Ser Ser Ser Ser Gly Asp Gln Ser Ser Asp Ser Leu Asn Ser 
305                 310                 315                 320 


Pro Thr Leu Leu Ala Leu 
                325     


<210>  73
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Ser Ser Ser Tyr Tyr Val Asn Ala Leu Phe Ser Lys Tyr Thr Ala 
1               5                   10                  15      


Gly Ala Ser Leu Phe Gln Asn Ala Glu Pro Thr Ser Cys Ser Phe Ala 
            20                  25                  30          


Pro Asn Ser Gln Arg Ser Gly Tyr Gly Ala Gly Ala Gly Ala Phe Ala 
        35                  40                  45              


Ser Thr Val Pro Gly Leu Tyr Asn Val Asn Ser Pro Leu Tyr Gln Ser 
    50                  55                  60                  


Pro Phe Ala Ser Gly Tyr Gly Leu Gly Ala Asp Ala Tyr Gly Asn Leu 
65                  70                  75                  80  


Pro Cys Ala Ser Tyr Asp Gln Asn Ile Pro Gly Leu Cys Ser Asp Leu 
                85                  90                  95      


Ala Lys Gly Ala Cys Asp Lys Thr Asp Glu Gly Ala Leu His Gly Ala 
            100                 105                 110         


Ala Glu Ala Asn Phe Arg Ile Tyr Pro Trp Met Arg Ser Ser Gly Pro 
        115                 120                 125             


Asp Arg Lys Arg Gly Arg Gln Thr Tyr Thr Arg Tyr Gln Thr Leu Glu 
    130                 135                 140                 


Leu Glu Lys Glu Phe His Phe Asn Arg Tyr Leu Thr Arg Arg Arg Arg 
145                 150                 155                 160 


Ile Glu Ile Ala His Ala Leu Cys Leu Thr Glu Arg Gln Ile Lys Ile 
                165                 170                 175     


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu His Lys Asp Glu 
            180                 185                 190         


Gly Pro Thr Ala Ala Ala Ala Pro Glu Gly Ala Val Pro Ser Ala Ala 
        195                 200                 205             


Ala Thr Ala Ala Ala Asp Lys Ala Asp Glu Glu Asp Asp Asp Glu Glu 
    210                 215                 220                 


Glu Glu Asp Glu Glu Glu 
225                 230 


<210>  74
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Ser Ser Ser Cys Ser Gly Leu Ser Arg Val Leu Val Ala Val Ala 
1               5                   10                  15      


Thr Ala Leu Val Ser Ala Ser Ser Pro Cys Pro Gln Ala Trp Gly Pro 
            20                  25                  30          


Pro Gly Val Gln Tyr Gly Gln Pro Gly Arg Ser Val Lys Leu Cys Cys 
        35                  40                  45              


Pro Gly Val Thr Ala Gly Asp Pro Val Ser Trp Phe Arg Asp Gly Glu 
    50                  55                  60                  


Pro Lys Leu Leu Gln Gly Pro Asp Ser Gly Leu Gly His Glu Leu Val 
65                  70                  75                  80  


Leu Ala Gln Ala Asp Ser Thr Asp Glu Gly Thr Tyr Ile Cys Gln Thr 
                85                  90                  95      


Leu Asp Gly Ala Leu Gly Gly Thr Val Thr Leu Gln Leu Gly Tyr Pro 
            100                 105                 110         


Pro Ala Arg Pro Val Val Ser Cys Gln Ala Ala Asp Tyr Glu Asn Phe 
        115                 120                 125             


Ser Cys Thr Trp Ser Pro Ser Gln Ile Ser Gly Leu Pro Thr Arg Tyr 
    130                 135                 140                 


Leu Thr Ser Tyr Arg Lys Lys Thr Val Leu Gly Ala Asp Ser Gln Arg 
145                 150                 155                 160 


Arg Ser Pro Ser Thr Gly Pro Trp Pro Cys Pro Gln Asp Pro Leu Gly 
                165                 170                 175     


Ala Ala Arg Cys Val Val His Gly Ala Glu Phe Trp Ser Gln Tyr Arg 
            180                 185                 190         


Ile Asn Val Thr Glu Val Asn Pro Leu Gly Ala Ser Thr Arg Leu Leu 
        195                 200                 205             


Asp Val Ser Leu Gln Ser Ile Leu Arg Pro Asp Pro Pro Gln Gly Leu 
    210                 215                 220                 


Arg Val Glu Ser Val Pro Gly Tyr Pro Arg Arg Leu Arg Ala Ser Trp 
225                 230                 235                 240 


Thr Tyr Pro Ala Ser Trp Pro Cys Gln Pro His Phe Leu Leu Lys Phe 
                245                 250                 255     


Arg Leu Gln Tyr Arg Pro Ala Gln His Pro Ala Trp Ser Thr Val Glu 
            260                 265                 270         


Pro Ala Gly Leu Glu Glu Val Ile Thr Asp Ala Val Ala Gly Leu Pro 
        275                 280                 285             


His Ala Val Arg Val Ser Ala Arg Asp Phe Leu Asp Ala Gly Thr Trp 
    290                 295                 300                 


Ser Thr Trp Ser Pro Glu Ala Trp Gly Thr Pro Ser Thr Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Glu Ile Pro Ala Trp Gly Gln Leu His Thr Gln Pro Glu Val 
                325                 330                 335     


Glu Pro Gln Val Asp Ser Pro Ala Pro Pro Arg Pro Ser Leu Gln Pro 
            340                 345                 350         


His Pro Arg Leu Leu Asp His Arg Asp Ser Val Glu Gln Val Ala Val 
        355                 360                 365             


Leu Ala Ser Leu Gly Ile Leu Ser Phe Leu Gly Leu Val Ala Gly Ala 
    370                 375                 380                 


Leu Ala Leu Gly Leu Trp Leu Arg Leu Arg Arg Gly Gly Lys Asp Gly 
385                 390                 395                 400 


Ser Pro Lys Pro Gly Phe Leu Ala Ser Val Ile Pro Val Asp Arg Arg 
                405                 410                 415     


Pro Gly Ala Pro Asn Leu 
            420         


<210>  75
<211>  941
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Ala Gly Ala Ala Ala Ala Val Ala Ala Gly Ala Ala Ala Gly Ala 
1               5                   10                  15      


Ala Ala Ala Ala Val Ser Val Ala Ala Pro Gly Arg Ala Ser Ala Pro 
            20                  25                  30          


Pro Pro Pro Pro Pro Val Tyr Cys Val Cys Arg Gln Pro Tyr Asp Val 
        35                  40                  45              


Asn Arg Phe Met Ile Glu Cys Asp Ile Cys Lys Asp Trp Phe His Gly 
    50                  55                  60                  


Ser Cys Val Gly Val Glu Glu His His Ala Val Asp Ile Asp Leu Tyr 
65                  70                  75                  80  


His Cys Pro Asn Cys Ala Val Leu His Gly Ser Ser Leu Met Lys Lys 
                85                  90                  95      


Arg Arg Asn Trp His Arg His Asp Tyr Thr Glu Ile Asp Asp Gly Ser 
            100                 105                 110         


Lys Pro Val Gln Ala Gly Thr Arg Thr Phe Ile Lys Glu Leu Arg Ser 
        115                 120                 125             


Arg Val Phe Pro Ser Ala Asp Glu Ile Ile Ile Lys Met His Gly Ser 
    130                 135                 140                 


Gln Leu Thr Gln Arg Tyr Leu Glu Lys His Gly Phe Asp Val Pro Ile 
145                 150                 155                 160 


Met Val Pro Lys Leu Asp Asp Leu Gly Leu Arg Leu Pro Ser Pro Thr 
                165                 170                 175     


Phe Ser Val Met Asp Val Glu Arg Tyr Val Gly Gly Asp Lys Val Ile 
            180                 185                 190         


Asp Val Ile Asp Val Ala Arg Gln Ala Asp Ser Lys Met Thr Leu His 
        195                 200                 205             


Asn Tyr Val Lys Tyr Phe Met Asn Pro Asn Arg Pro Lys Val Leu Asn 
    210                 215                 220                 


Val Ile Ser Leu Glu Phe Ser Asp Thr Lys Met Ser Glu Leu Val Glu 
225                 230                 235                 240 


Val Pro Asp Ile Ala Lys Lys Leu Ser Trp Val Glu Asn Tyr Trp Pro 
                245                 250                 255     


Asp Asp Ser Val Phe Pro Lys Pro Phe Val Gln Lys Tyr Cys Leu Met 
            260                 265                 270         


Gly Val Gln Asp Ser Tyr Thr Asp Phe His Ile Asp Phe Gly Gly Thr 
        275                 280                 285             


Ser Val Trp Tyr His Val Leu Trp Gly Glu Lys Ile Phe Tyr Leu Ile 
    290                 295                 300                 


Lys Pro Thr Asp Glu Asn Leu Ala Arg Tyr Glu Ser Trp Ser Ser Ser 
305                 310                 315                 320 


Val Thr Gln Ser Glu Val Phe Phe Gly Asp Lys Val Asp Lys Cys Tyr 
                325                 330                 335     


Lys Cys Val Val Lys Gln Gly His Thr Leu Phe Val Pro Thr Gly Trp 
            340                 345                 350         


Ile His Ala Val Leu Thr Ser Gln Asp Cys Met Ala Phe Gly Gly Asn 
        355                 360                 365             


Phe Leu His Asn Leu Asn Ile Gly Met Gln Leu Arg Cys Tyr Glu Met 
    370                 375                 380                 


Glu Lys Arg Leu Lys Thr Pro Asp Leu Phe Lys Phe Pro Phe Phe Glu 
385                 390                 395                 400 


Ala Ile Cys Trp Phe Val Ala Lys Asn Leu Leu Glu Thr Leu Lys Glu 
                405                 410                 415     


Leu Arg Glu Asp Gly Phe Gln Pro Gln Thr Tyr Leu Val Gln Gly Val 
            420                 425                 430         


Lys Ala Leu His Thr Ala Leu Lys Leu Trp Met Lys Lys Glu Leu Val 
        435                 440                 445             


Ser Glu His Ala Phe Glu Ile Pro Asp Asn Val Arg Pro Gly His Leu 
    450                 455                 460                 


Ile Lys Glu Leu Ser Lys Val Ile Arg Ala Ile Glu Glu Glu Asn Gly 
465                 470                 475                 480 


Lys Pro Val Lys Ser Gln Gly Ile Pro Ile Val Cys Pro Val Ser Arg 
                485                 490                 495     


Ser Ser Asn Glu Ala Thr Ser Pro Tyr His Ser Arg Arg Lys Met Arg 
            500                 505                 510         


Lys Leu Arg Asp His Asn Val Arg Thr Pro Ser Asn Leu Asp Ile Leu 
        515                 520                 525             


Glu Leu His Thr Arg Glu Val Leu Lys Arg Leu Glu Met Cys Pro Trp 
    530                 535                 540                 


Glu Glu Asp Ile Leu Ser Ser Lys Leu Asn Gly Lys Phe Asn Lys His 
545                 550                 555                 560 


Leu Gln Pro Ser Ser Thr Val Pro Glu Trp Arg Ala Lys Asp Asn Asp 
                565                 570                 575     


Leu Arg Leu Leu Leu Thr Asn Gly Arg Ile Ile Lys Asp Glu Arg Gln 
            580                 585                 590         


Pro Phe Ala Asp Gln Ser Leu Tyr Thr Ala Asp Ser Glu Asn Glu Glu 
        595                 600                 605             


Asp Lys Arg Arg Thr Lys Lys Ala Lys Met Lys Ile Glu Glu Ser Ser 
    610                 615                 620                 


Gly Val Glu Gly Val Glu His Glu Glu Ser Gln Lys Pro Leu Asn Gly 
625                 630                 635                 640 


Phe Phe Thr Arg Val Lys Ser Glu Leu Arg Ser Arg Ser Ser Gly Tyr 
                645                 650                 655     


Ser Asp Ile Ser Glu Ser Glu Asp Ser Gly Pro Glu Cys Thr Ala Leu 
            660                 665                 670         


Lys Ser Ile Phe Thr Thr Glu Glu Ser Glu Ser Ser Gly Asp Glu Lys 
        675                 680                 685             


Lys Gln Glu Ile Thr Ser Asn Phe Lys Glu Glu Ser Asn Val Met Arg 
    690                 695                 700                 


Asn Phe Leu Gln Lys Ser Gln Lys Pro Ser Arg Ser Glu Ile Pro Ile 
705                 710                 715                 720 


Lys Arg Glu Cys Pro Thr Ser Thr Ser Thr Glu Glu Glu Ala Ile Gln 
                725                 730                 735     


Gly Met Leu Ser Met Ala Gly Leu His Tyr Ser Thr Cys Leu Gln Arg 
            740                 745                 750         


Gln Ile Gln Ser Thr Asp Cys Ser Gly Glu Arg Asn Ser Leu Gln Asp 
        755                 760                 765             


Pro Ser Ser Cys His Gly Ser Asn His Glu Val Arg Gln Leu Tyr Arg 
    770                 775                 780                 


Tyr Asp Lys Pro Val Glu Cys Gly Tyr His Val Lys Thr Glu Asp Pro 
785                 790                 795                 800 


Asp Leu Arg Thr Ser Ser Trp Ile Lys Gln Phe Asp Thr Ser Arg Phe 
                805                 810                 815     


His Pro Gln Asp Leu Ser Arg Ser Gln Lys Cys Ile Arg Lys Glu Gly 
            820                 825                 830         


Ser Ser Glu Ile Ser Gln Arg Val Gln Ser Arg Asn Tyr Val Asp Ser 
        835                 840                 845             


Ser Gly Ser Ser Leu Gln Asn Gly Lys Tyr Met Gln Asn Ser Asn Leu 
    850                 855                 860                 


Thr Ser Gly Ala Cys Gln Ile Ser Asn Gly Ser Leu Ser Pro Glu Arg 
865                 870                 875                 880 


Pro Val Gly Glu Thr Ser Phe Ser Val Pro Leu His Pro Thr Lys Arg 
                885                 890                 895     


Pro Ala Ser Asn Pro Pro Pro Ile Ser Asn Gln Ala Thr Lys Gly Lys 
            900                 905                 910         


Arg Pro Lys Lys Gly Met Ala Thr Ala Lys Gln Arg Leu Gly Lys Ile 
        915                 920                 925             


Leu Lys Leu Asn Arg Asn Gly His Ala Arg Phe Phe Val 
    930                 935                 940     


<210>  76
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Asp Val Leu Ala Ser Tyr Ser Ile Phe Gln Glu Leu Gln Leu Val 
1               5                   10                  15      


His Asp Thr Gly Tyr Phe Ser Ala Leu Pro Ser Leu Glu Glu Thr Trp 
            20                  25                  30          


Gln Gln Thr Cys Leu Glu Leu Glu Arg Tyr Leu Gln Thr Glu Pro Arg 
        35                  40                  45              


Arg Ile Ser Glu Thr Phe Gly Glu Asp Leu Asp Cys Phe Leu His Ala 
    50                  55                  60                  


Ser Pro Pro Pro Cys Ile Glu Glu Ser Phe Arg Arg Leu Asp Pro Leu 
65                  70                  75                  80  


Leu Leu Pro Val Glu Ala Ala Ile Cys Glu Lys Ser Ser Ala Val Asp 
                85                  90                  95      


Ile Leu Leu Ser Arg Asp Lys Leu Leu Ser Glu Thr Cys Leu Ser Leu 
            100                 105                 110         


Gln Pro Ala Ser Ser Ser Leu Asp Ser Tyr Thr Ala Val Asn Gln Ala 
        115                 120                 125             


Gln Leu Asn Ala Val Thr Ser Leu Thr Pro Pro Ser Ser Pro Glu Leu 
    130                 135                 140                 


Ser Arg His Leu Val Lys Thr Ser Gln Thr Leu Ser Ala Val Asp Gly 
145                 150                 155                 160 


Thr Val Thr Leu Lys Leu Val Ala Lys Lys Ala Ala Leu Ser Ser Val 
                165                 170                 175     


Lys Val Gly Gly Val Ala Thr Ala Ala Ala Ala Val Thr Ala Ala Gly 
            180                 185                 190         


Ala Val Lys Ser Gly Gln Ser Asp Ser Asp Gln Gly Gly Leu Gly Ala 
        195                 200                 205             


Glu Ala Cys Pro Glu Asn Lys Lys Arg Val His Arg Cys Gln Phe Asn 
    210                 215                 220                 


Gly Cys Arg Lys Val Tyr Thr Lys Ser Ser His Leu Lys Ala His Gln 
225                 230                 235                 240 


Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Trp Glu Gly Cys 
                245                 250                 255     


Glu Trp Arg Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg Lys 
            260                 265                 270         


His Thr Gly Ala Lys Pro Phe Lys Cys Asn His Cys Asp Arg Cys Phe 
        275                 280                 285             


Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Ile 
    290                 295                 300         


<210>  77
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Ser Ala Ala Ala Tyr Met Asp Phe Val Ala Ala Gln Cys Leu Val 
1               5                   10                  15      


Ser Ile Ser Asn Arg Ala Ala Val Pro Glu His Gly Val Ala Pro Asp 
            20                  25                  30          


Ala Glu Arg Leu Arg Leu Pro Glu Arg Glu Val Thr Lys Glu His Gly 
        35                  40                  45              


Asp Pro Gly Asp Thr Trp Lys Asp Tyr Cys Thr Leu Val Thr Ile Ala 
    50                  55                  60                  


Lys Ser Leu Leu Asp Leu Asn Lys Tyr Arg Pro Ile Gln Thr Pro Ser 
65                  70                  75                  80  


Val Cys Ser Asp Ser Leu Glu Ser Pro Asp Glu Asp Met Gly Ser Asp 
                85                  90                  95      


Ser Asp Val Thr Thr Glu Ser Gly Ser Ser Pro Ser His Ser Pro Glu 
            100                 105                 110         


Glu Arg Gln Asp Pro Gly Ser Ala Pro Ser Pro Leu Ser Leu Leu His 
        115                 120                 125             


Pro Gly Val Ala Ala Lys Gly Lys His Ala Ser Glu Lys Arg His Lys 
    130                 135                 140                 


Cys Pro Tyr Ser Gly Cys Gly Lys Val Tyr Gly Lys Ser Ser His Leu 
145                 150                 155                 160 


Lys Ala His Tyr Arg Val His Thr Gly Glu Arg Pro Phe Pro Cys Thr 
                165                 170                 175     


Trp Pro Asp Cys Leu Lys Lys Phe Ser Arg Ser Asp Glu Leu Thr Arg 
            180                 185                 190         


His Tyr Arg Thr His Thr Gly Glu Lys Gln Phe Arg Cys Pro Leu Cys 
        195                 200                 205             


Glu Lys Arg Phe Met Arg Ser Asp His Leu Thr Lys His Ala Arg Arg 
    210                 215                 220                 


His Thr Glu Phe His Pro Ser Met Ile Lys Arg Ser Lys Lys Ala Leu 
225                 230                 235                 240 


Ala Asn Ala Leu 
                


<210>  78
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Ser Val Asp Pro Leu Ser Ser Lys Ala Leu Lys Ile Lys Arg Glu 
1               5                   10                  15      


Leu Ser Glu Asn Thr Pro His Leu Ser Asp Glu Ala Leu Met Gly Leu 
            20                  25                  30          


Ser Val Arg Glu Leu Asn Arg His Leu Arg Gly Leu Ser Ala Glu Glu 
        35                  40                  45              


Val Thr Arg Leu Lys Gln Arg Arg Arg Thr Leu Lys Asn Arg Gly Tyr 
    50                  55                  60                  


Ala Ala Ser Cys Arg Val Lys Arg Val Cys Gln Lys Glu Glu Leu Gln 
65                  70                  75                  80  


Lys Gln Lys Ser Glu Leu Glu Arg Glu Val Asp Lys Leu Ala Arg Glu 
                85                  90                  95      


Asn Ala Ala Met Arg Leu Glu Leu Asp Ala Leu Arg Gly Lys Cys Glu 
            100                 105                 110         


Ala Leu Gln Gly Phe Ala Arg Ser Val Ala Ala Ala Arg Gly Pro Ala 
        115                 120                 125             


Thr Leu Val Ala Pro Ala Ser Val Ile Thr Ile Val Lys Ser Thr Pro 
    130                 135                 140                 


Gly Ser Gly Ser Gly Pro Ala His Gly Pro Asp Pro Ala His Gly Pro 
145                 150                 155                 160 


Ala Ser Cys Ser 
                


<210>  79
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Ser Gln Trp Asn Gln Val Gln Gln Leu Glu Ile Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val Asp Gln Phe Tyr Asp Asp Asn Phe Pro Met Glu Ile Arg His 
            20                  25                  30          


Leu Leu Ala Gln Trp Ile Glu Asn Gln Asp Trp Glu Ala Ala Ser Asn 
        35                  40                  45              


Asn Glu Thr Met Ala Thr Ile Leu Leu Gln Asn Leu Leu Ile Gln Leu 
    50                  55                  60                  


Asp Glu Gln Leu Gly Arg Val Ser Lys Glu Lys Asn Leu Leu Leu Ile 
65                  70                  75                  80  


His Asn Leu Lys Arg Ile Arg Lys Val Leu Gln Gly Lys Phe His Gly 
                85                  90                  95      


Asn Pro Met His Val Ala Val Val Ile Ser Asn Cys Leu Arg Glu Glu 
            100                 105                 110         


Arg Arg Ile Leu Ala Ala Ala Asn Met Pro Val Gln Gly Pro Leu Glu 
        115                 120                 125             


Lys Ser Leu Gln Ser Ser Ser Val Ser Glu Arg Gln Arg Asn Val Glu 
    130                 135                 140                 


His Lys Val Ala Ala Ile Lys Asn Ser Val Gln Met Thr Glu Gln Asp 
145                 150                 155                 160 


Thr Lys Tyr Leu Glu Asp Leu Gln Asp Glu Phe Asp Tyr Arg Tyr Lys 
                165                 170                 175     


Thr Ile Gln Thr Met Asp Gln Ser Asp Lys Asn Ser Ala Met Val Asn 
            180                 185                 190         


Gln Glu Val Leu Thr Leu Gln Glu Met Leu Asn Ser Leu Asp Phe Lys 
        195                 200                 205             


Arg Lys Glu Ala Leu Ser Lys Met Thr Gln Ile Ile His Glu Thr Asp 
    210                 215                 220                 


Leu Leu Met Asn Thr Met Leu Ile Glu Glu Leu Gln Asp Trp Lys Arg 
225                 230                 235                 240 


Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Leu His Asn Gly Leu Asp 
                245                 250                 255     


Gln Leu Gln Asn Cys Phe Thr Leu Leu Ala Glu Ser Leu Phe Gln Leu 
            260                 265                 270         


Arg Arg Gln Leu Glu Lys Leu Glu Glu Gln Ser Thr Lys Met Thr Tyr 
        275                 280                 285             


Glu Gly Asp Pro Ile Pro Met Gln Arg Thr His Met Leu Glu Arg Val 
    290                 295                 300                 


Thr Phe Leu Ile Tyr Asn Leu Phe Lys Asn Ser Phe Val Val Glu Arg 
305                 310                 315                 320 


Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys Thr 
                325                 330                 335     


Leu Ile Gln Phe Thr Val Lys Leu Arg Leu Leu Ile Lys Leu Pro Glu 
            340                 345                 350         


Leu Asn Tyr Gln Val Lys Val Lys Ala Ser Ile Asp Lys Asn Val Ser 
        355                 360                 365             


Thr Leu Ser Asn Arg Arg Phe Val Leu Cys Gly Thr Asn Val Lys Ala 
    370                 375                 380                 


Met Ser Ile Glu Glu Ser Ser Asn Gly Ser Leu Ser Val Glu Phe Arg 
385                 390                 395                 400 


His Leu Gln Pro Lys Glu Met Lys Ser Ser Ala Gly Gly Lys Gly Asn 
                405                 410                 415     


Glu Gly Cys His Met Val Thr Glu Glu Leu His Ser Ile Thr Phe Glu 
            420                 425                 430         


Thr Gln Ile Cys Leu Tyr Gly Leu Thr Ile Asp Leu Glu Thr Ser Ser 
        435                 440                 445             


Leu Pro Val Val Met Ile Ser Asn Val Ser Gln Leu Pro Asn Ala Trp 
    450                 455                 460                 


Ala Ser Ile Ile Trp Tyr Asn Val Ser Thr Asn Asp Ser Gln Asn Leu 
465                 470                 475                 480 


Val Phe Phe Asn Asn Pro Pro Pro Ala Thr Leu Ser Gln Leu Leu Glu 
                485                 490                 495     


Val Met Ser Trp Gln Phe Ser Ser Tyr Val Gly Arg Gly Leu Asn Ser 
            500                 505                 510         


Asp Gln Leu His Met Leu Ala Glu Lys Leu Thr Val Gln Ser Ser Tyr 
        515                 520                 525             


Ser Asp Gly His Leu Thr Trp Ala Lys Phe Cys Lys Glu His Leu Pro 
    530                 535                 540                 


Gly Lys Ser Phe Thr Phe Trp Thr Trp Leu Glu Ala Ile Leu Asp Leu 
545                 550                 555                 560 


Ile Lys Lys His Ile Leu Pro Leu Trp Ile Asp Gly Tyr Val Met Gly 
                565                 570                 575     


Phe Val Ser Lys Glu Lys Glu Arg Leu Leu Leu Lys Asp Lys Met Pro 
            580                 585                 590         


Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser His Leu Gly Gly Ile Thr 
        595                 600                 605             


Phe Thr Trp Val Asp His Ser Glu Ser Gly Glu Val Arg Phe His Ser 
    610                 615                 620                 


Val Glu Pro Tyr Asn Lys Gly Arg Leu Ser Ala Leu Pro Phe Ala Asp 
625                 630                 635                 640 


Ile Leu Arg Asp Tyr Lys Val Ile Met Ala Glu Asn Ile Pro Glu Asn 
                645                 650                 655     


Pro Leu Lys Tyr Leu Tyr Pro Asp Ile Pro Lys Asp Lys Ala Phe Gly 
            660                 665                 670         


Lys His Tyr Ser Ser Gln Pro Cys Glu Val Ser Arg Pro Thr Glu Arg 
        675                 680                 685             


Gly Asp Lys Gly Tyr Val Pro Ser Val Phe Ile Pro Ile Ser Thr Ile 
    690                 695                 700                 


Arg Ser Asp Ser Thr Glu Pro His Ser Pro Ser Asp Leu Leu Pro Met 
705                 710                 715                 720 


Ser Pro Ser Val Tyr Ala Val Leu Arg Glu Asn Leu Ser Pro Thr Thr 
                725                 730                 735     


Ile Glu Thr Ala Met Lys Ser Pro Tyr Ser Ala Glu 
            740                 745             


<210>  80
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asp Val Arg Phe Tyr Pro Pro Pro Ala Gln Pro Ala Ala Ala Pro 
1               5                   10                  15      


Asp Ala Pro Cys Leu Gly Pro Ser Pro Cys Leu Asp Pro Tyr Tyr Cys 
            20                  25                  30          


Asn Lys Phe Asp Gly Glu Asn Met Tyr Met Ser Met Thr Glu Pro Ser 
        35                  40                  45              


Gln Asp Tyr Val Pro Ala Ser Gln Ser Tyr Pro Gly Pro Ser Leu Glu 
    50                  55                  60                  


Ser Glu Asp Phe Asn Ile Pro Pro Ile Thr Pro Pro Ser Leu Pro Asp 
65                  70                  75                  80  


His Ser Leu Val His Leu Asn Glu Val Glu Ser Gly Tyr His Ser Leu 
                85                  90                  95      


Cys His Pro Met Asn His Asn Gly Leu Leu Pro Phe His Pro Gln Asn 
            100                 105                 110         


Met Asp Leu Pro Glu Ile Thr Val Ser Asn Met Leu Gly Gln Asp Gly 
        115                 120                 125             


Thr Leu Leu Ser Asn Ser Ile Ser Val Met Pro Asp Ile Arg Asn Pro 
    130                 135                 140                 


Glu Gly Thr Gln Tyr Ser Ser His Pro Gln Met Ala Ala Met Arg Pro 
145                 150                 155                 160 


Arg Gly Gln Pro Ala Asp Ile Arg Gln Gln Pro Gly Met Met Pro His 
                165                 170                 175     


Gly Gln Leu Thr Thr Ile Asn Gln Ser Gln Leu Ser Ala Gln Leu Gly 
            180                 185                 190         


Leu Asn Met Gly Gly Ser Asn Val Pro His Asn Ser Pro Ser Pro Pro 
        195                 200                 205             


Gly Ser Lys Ser Ala Thr Pro Ser Pro Ser Ser Ser Val His Glu Asp 
    210                 215                 220                 


Glu Gly Asp Asp Thr Ser Lys Ile Asn Gly Gly Glu Lys Arg Pro Ala 
225                 230                 235                 240 


Ser Asp Met Gly Lys Lys Pro Lys Thr Pro Lys Lys Lys Lys Lys Lys 
                245                 250                 255     


Asp Pro Asn Glu Pro Gln Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe 
            260                 265                 270         


Arg Asp Thr Gln Ala Ala Ile Lys Gly Gln Asn Pro Asn Ala Thr Phe 
        275                 280                 285             


Gly Glu Val Ser Lys Ile Val Ala Ser Met Trp Asp Gly Leu Gly Glu 
    290                 295                 300                 


Glu Gln Lys Gln Val Tyr Lys Lys Lys Thr Glu Ala Ala Lys Lys Glu 
305                 310                 315                 320 


Tyr Leu Lys Gln Leu Ala Ala Tyr Arg Ala Ser Leu Val Ser Lys Ser 
                325                 330                 335     


Tyr Ser Glu Pro Val Asp Val Lys Thr Ser Gln Pro Pro Gln Leu Ile 
            340                 345                 350         


Asn Ser Lys Pro Ser Val Phe His Gly Pro Ser Gln Ala His Ser Ala 
        355                 360                 365             


Leu Tyr Leu Ser Ser His Tyr His Gln Gln Pro Gly Met Asn Pro His 
    370                 375                 380                 


Leu Thr Ala Met His Pro Ser Leu Pro Arg Asn Ile Ala Pro Lys Pro 
385                 390                 395                 400 


Asn Asn Gln Met Pro Val Thr Val Ser Ile Ala Asn Met Ala Val Ser 
                405                 410                 415     


Pro Pro Pro Pro Leu Gln Ile Ser Pro Pro Leu His Gln His Leu Asn 
            420                 425                 430         


Met Gln Gln His Gln Pro Leu Thr Met Gln Gln Pro Leu Gly Asn Gln 
        435                 440                 445             


Leu Pro Met Gln Val Gln Ser Ala Leu His Ser Pro Thr Met Gln Gln 
    450                 455                 460                 


Gly Phe Thr Leu Gln Pro Asp Tyr Gln Thr Ile Ile Asn Pro Thr Ser 
465                 470                 475                 480 


Thr Ala Ala Gln Val Val Thr Gln Ala Met Glu Tyr Val Arg Ser Gly 
                485                 490                 495     


Cys Arg Asn Pro Pro Pro Gln Pro Val Asp Trp Asn Asn Asp Tyr Cys 
            500                 505                 510         


Ser Ser Gly Gly Met Gln Arg Asp Lys Ala Leu Tyr Leu Thr 
        515                 520                 525     


<210>  81
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Asp Leu Thr Lys Met Gly Met Ile Gln Leu Gln Asn Pro Ser His 
1               5                   10                  15      


Pro Thr Gly Leu Leu Cys Lys Ala Asn Gln Met Arg Leu Ala Gly Thr 
            20                  25                  30          


Leu Cys Asp Val Val Ile Met Val Asp Ser Gln Glu Phe His Ala His 
        35                  40                  45              


Arg Thr Val Leu Ala Cys Thr Ser Lys Met Phe Glu Ile Leu Phe His 
    50                  55                  60                  


Arg Asn Ser Gln His Tyr Thr Leu Asp Phe Leu Ser Pro Lys Thr Phe 
65                  70                  75                  80  


Gln Gln Ile Leu Glu Tyr Ala Tyr Thr Ala Thr Leu Gln Ala Lys Ala 
                85                  90                  95      


Glu Asp Leu Asp Asp Leu Leu Tyr Ala Ala Glu Ile Leu Glu Ile Glu 
            100                 105                 110         


Tyr Leu Glu Glu Gln Cys Leu Lys Met Leu Glu Thr Ile Gln Ala Ser 
        115                 120                 125             


Asp Asp Asn Asp Thr Glu Ala Thr Met Ala Asp Gly Gly Ala Glu Glu 
    130                 135                 140                 


Glu Glu Asp Arg Lys Ala Arg Tyr Leu Lys Asn Ile Phe Ile Ser Lys 
145                 150                 155                 160 


His Ser Ser Glu Glu Ser Gly Tyr Ala Ser Val Ala Gly Gln Ser Leu 
                165                 170                 175     


Pro Gly Pro Met Val Asp Gln Ser Pro Ser Val Ser Thr Ser Phe Gly 
            180                 185                 190         


Leu Ser Ala Met Ser Pro Thr Lys Ala Ala Val Asp Ser Leu Met Thr 
        195                 200                 205             


Ile Gly Gln Ser Leu Leu Gln Gly Thr Leu Gln Pro Pro Ala Gly Pro 
    210                 215                 220                 


Glu Glu Pro Thr Leu Ala Gly Gly Gly Arg His Pro Gly Val Ala Glu 
225                 230                 235                 240 


Val Lys Thr Glu Met Met Gln Val Asp Glu Val Pro Ser Gln Asp Ser 
                245                 250                 255     


Pro Gly Ala Ala Glu Ser Ser Ile Ser Gly Gly Met Gly Asp Lys Val 
            260                 265                 270         


Glu Glu Arg Gly Lys Glu Gly Pro Gly Thr Pro Thr Arg Ser Ser Val 
        275                 280                 285             


Ile Thr Ser Ala Arg Glu Leu His Tyr Gly Arg Glu Glu Ser Ala Glu 
    290                 295                 300                 


Gln Val Pro Pro Pro Ala Glu Ala Gly Gln Ala Pro Thr Gly Arg Pro 
305                 310                 315                 320 


Glu His Pro Ala Pro Pro Pro Glu Lys His Leu Gly Ile Tyr Ser Val 
                325                 330                 335     


Leu Pro Asn His Lys Ala Asp Ala Val Leu Ser Met Pro Ser Ser Val 
            340                 345                 350         


Thr Ser Gly Leu His Val Gln Pro Ala Leu Ala Val Ser Met Asp Phe 
        355                 360                 365             


Ser Thr Tyr Gly Gly Leu Leu Pro Gln Gly Phe Ile Gln Arg Glu Leu 
    370                 375                 380                 


Phe Ser Lys Leu Gly Glu Leu Ala Val Gly Met Lys Ser Glu Ser Arg 
385                 390                 395                 400 


Thr Ile Gly Glu Gln Cys Ser Val Cys Gly Val Glu Leu Pro Asp Asn 
                405                 410                 415     


Glu Ala Val Glu Gln His Arg Lys Leu His Ser Gly Met Lys Thr Tyr 
            420                 425                 430         


Gly Cys Glu Leu Cys Gly Lys Arg Phe Leu Asp Ser Leu Arg Leu Arg 
        435                 440                 445             


Met His Leu Leu Ala His Ser Ala Gly Ala Lys Ala Phe Val Cys Asp 
    450                 455                 460                 


Gln Cys Gly Ala Gln Phe Ser Lys Glu Asp Ala Leu Glu Thr His Arg 
465                 470                 475                 480 


Gln Thr His Thr Gly Thr Asp Met Ala Val Phe Cys Leu Leu Cys Gly 
                485                 490                 495     


Lys Arg Phe Gln Ala Gln Ser Ala Leu Gln Gln His Met Glu Val His 
            500                 505                 510         


Ala Gly Val Arg Ser Tyr Ile Cys Ser Glu Cys Asn Arg Thr Phe Pro 
        515                 520                 525             


Ser His Thr Ala Leu Lys Arg His Leu Arg Ser His Thr Gly Asp His 
    530                 535                 540                 


Pro Tyr Glu Cys Glu Phe Cys Gly Ser Cys Phe Arg Asp Glu Ser Thr 
545                 550                 555                 560 


Leu Lys Ser His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                565                 570                 575     


Asn Gly Cys Gly Lys Lys Phe Ser Leu Lys His Gln Leu Glu Thr His 
            580                 585                 590         


Tyr Arg Val His Thr Gly Glu Lys Pro Phe Glu Cys Lys Leu Cys His 
        595                 600                 605             


Gln Arg Ser Arg Asp Tyr Ser Ala Met Ile Lys His Leu Arg Thr His 
    610                 615                 620                 


Asn Gly Ala Ser Pro Tyr Gln Cys Thr Ile Cys Thr Glu Tyr Cys Pro 
625                 630                 635                 640 


Ser Leu Ser Ser Met Gln Lys His Met Lys Gly His Lys Pro Glu Glu 
                645                 650                 655     


Ile Pro Pro Asp Trp Arg Ile Glu Lys Thr Tyr Leu Tyr Leu Cys Tyr 
            660                 665                 670         


Val 
    


