                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       SHALGI, Ruth
       CHUDERLAND, Dana
 
<120>  PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT OF 
       UTERINE FIBROIDS

<130>  64145

<150>  US 62/083,356
<151>  2014-11-24

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1490
<212>  DNA
<213>  Homo sapiens

<400>  1
ggacgctgga ttagaaggca gcaaaaaaag atctgtgctg gctggagccc cctcagtgtg       60

caggcttaga gggactaggc tgggtgtgga gctgcagcgt atccacaggc cccaggatgc      120

aggccctggt gctactcctc tgcattggag ccctcctcgg gcacagcagc tgccagaacc      180

ctgccagccc cccggaggag ggctccccag accccgacag cacaggggcg ctggtggagg      240

aggaggatcc tttcttcaaa gtccccgtga acaagctggc agcggctgtc tccaacttcg      300

gctatgacct gtaccgggtg cgatccagca tgagccccac gaccaacgtg ctcctgtctc      360

ctctcagtgt ggccacggcc ctctcggccc tctcgctggg agcggacgag cgaacagaat      420

ccatcattca ccgggctctc tactatgact tgatcagcag cccagacatc catggtacct      480

ataaggagct ccttgacacg gtcactgccc cccagaagaa cctcaagagt gcctcccgga      540

tcgtctttga gaagaagctr cgcataaaat ccagctttgt ggcacctctg gaaaagtcat      600

atgggaccag gcccagagtc ctgacgggca accctcgctt ggacctgcaa gagatcaaca      660

actgggtgca ggcgcagatg aaagggaagc tcgccaggtc cacaaaggaa attcccgatg      720

agatcagcat tctccttctc ggtgtggcgc acttcaaggg gcagtgggta acaaagtttg      780

actccagaaa gacttccctc gaggatttct acttggatga agagaggacc gtgagggtcc      840

ccatgatgtc ggaccctaag gctgttttac gctatggctt ggattcagat ctcagctgca      900

agattgccca gctgcccttg accggaagca tgagtatcat cttcttcctg cccctgaaag      960

tgacccagaa tttgaccttg atagaggaga gcctcacctc cgagttcatt catgacatag     1020

accgagaact gaagaccgtg caggcggtcc tcactgtccc caagctgaag ctgagttacg     1080

aaggcgaagt caccaagtcc ctgcaggaga tgaagctgca atccttgttt gattcaccag     1140

actttagcaa gatcacaggc aaacccatca agctgactca ggtggaacac cgggctggct     1200

ttgagtggaa cgaggatggg gcgggaacca cccccagccc agggctgcag cctgcccacc     1260

tcaccttccc gctggactat caccttaacc agcctttcat cttcgtactg agggacacag     1320

acacaggggc ccttctcttc attggcaaga ttctggaccc caggggcccc taatatccca     1380

gtttaatatt ccaataccct agaagaaaac ccgagggaca gcagattcca caggacacga     1440

aggctgcccc tgtaaggttt caatgcatac aataaaagag ctttatccct                1490


<210>  2
<211>  1552
<212>  DNA
<213>  Homo sapiens

<400>  2
ggtcgcttta agaaaggagt agctgtaatc tgaagcctgc tggacgctgg attagaaggc       60

agcaaaaaaa gctctgtgct ggctggagcc ccctcagtgt gcaggcttag agggactagg      120

ctgggtgtgg agctgcagcg tatccacagg ccccaggatg caggccctgg tgctactcct      180

ctgcattgga gccctcctcg ggcacagcag ctgccagaac cctgccagcc ccccggagga      240

gggctcccca gaccccgaca gcacaggggc gctggtggag gaggaggatc ctttcttcaa      300

agtccccgtg aacaagctgg cagcggctgt ctccaacttc ggctatgacc tgtaccgggt      360

gcgatccagc acgagcccca cgaccaacgt gctcctgtct cctctcagtg tggccacggc      420

cctctcggcc ctctcgctgg gagcggagca gcgaacagaa tccatcattc accgggctct      480

ctactatgac ttgatcagca gcccagacat ccatggtacc tataaggagc tccttgacac      540

ggtcactgcc ccccagaaga acctcaagag tgcctcccgg atcgtctttg agaagaagct      600

gcgcataaaa tccagctttg tggcacctct ggaaaagtca tatgggacca ggcccagagt      660

cctgacgggc aaccctcgct tggacctgca agagatcaac aactgggtgc aggcgcagat      720

gaaagggaag ctcgccaggt ccacaaagga aattcccgat gagatcagca ttctccttct      780

cggtgtggcg cacttcaagg ggcagtgggt aacaaagttt gactccagaa agacttccct      840

cgaggatttc tacttggatg aagagaggac cgtgagggtc cccatgatgt cggaccctaa      900

ggctgtttta cgctatggct tggattcaga tctcagctgc aagattgccc agctgccctt      960

gaccggaagc atgagtatca tcttcttcct gcccctgaaa gtgacccaga atttgacctt     1020

gatagaggag agcctcacct ccgagttcat tcatgacata gaccgagaac tgaagaccgt     1080

gcaggcggtc ctcactgtcc ccaagctgaa gctgagttat gaaggcgaag tcaccaagtc     1140

cctgcaggag atgaagctgc aatccttgtt tgattcacca gactttagca agatcacagg     1200

caaacccatc aagctgactc aggtggaaca ccgggctggc tttgagtgga acgaggatgg     1260

ggcgggaacc acccccagcc cagggctgca gcctgcccac ctcaccttcc cgctggacta     1320

tcaccttaac cagcctttca tcttcgtact gagggacaca gacacagggg cccttctctt     1380

cattggcaag attctggacc ccaggggccc ctaatatccc agtttaatat tccaataccc     1440

tagaagaaaa cccgagggac agcagattcc acaggacacg aaggctgccc ctgtaaggtt     1500

tcaatgcata caataaaaga gctttatccc taaaaaaaaa aaaaaaaaaa aa             1552


<210>  3
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys Gln Asn Pro Ala Ser Pro Pro Glu Glu Gly Ser Pro Asp 
            20                  25                  30          


Pro Asp Ser Thr Gly Ala Leu Val Glu Glu Glu Asp Pro Phe Phe Lys 
        35                  40                  45              


Val Pro Val Asn Lys Leu Ala Ala Ala Val Ser Asn Phe Gly Tyr Asp 
    50                  55                  60                  


Leu Tyr Arg Val Arg Ser Ser Thr Ser Pro Thr Thr Asn Val Leu Leu 
65                  70                  75                  80  


Ser Pro Leu Ser Val Ala Thr Ala Leu Ser Ala Leu Ser Leu Gly Ala 
                85                  90                  95      


Glu Gln Arg Thr Glu Ser Ile Ile His Arg Ala Leu Tyr Tyr Asp Leu 
            100                 105                 110         


Ile Ser Ser Pro Asp Ile His Gly Thr Tyr Lys Glu Leu Leu Asp Thr 
        115                 120                 125             


Val Thr Ala Pro Gln Lys Asn Leu Lys Ser Ala Ser Arg Ile Val Phe 
    130                 135                 140                 


Glu Lys Lys Leu Arg Ile Lys Ser Ser Phe Val Ala Pro Leu Glu Lys 
145                 150                 155                 160 


Ser Tyr Gly Thr Arg Pro Arg Val Leu Thr Gly Asn Pro Arg Leu Asp 
                165                 170                 175     


Leu Gln Glu Ile Asn Asn Trp Val Gln Ala Gln Met Lys Gly Lys Leu 
            180                 185                 190         


Ala Arg Ser Thr Lys Glu Ile Pro Asp Glu Ile Ser Ile Leu Leu Leu 
        195                 200                 205             


Gly Val Ala His Phe Lys Gly Gln Trp Val Thr Lys Phe Asp Ser Arg 
    210                 215                 220                 


Lys Thr Ser Leu Glu Asp Phe Tyr Leu Asp Glu Glu Arg Thr Val Arg 
225                 230                 235                 240 


Val Pro Met Met Ser Asp Pro Lys Ala Val Leu Arg Tyr Gly Leu Asp 
                245                 250                 255     


Ser Asp Leu Ser Cys Lys Ile Ala Gln Leu Pro Leu Thr Gly Ser Met 
            260                 265                 270         


Ser Ile Ile Phe Phe Leu Pro Leu Lys Val Thr Gln Asn Leu Thr Leu 
        275                 280                 285             


Ile Glu Glu Ser Leu Thr Ser Glu Phe Ile His Asp Ile Asp Arg Glu 
    290                 295                 300                 


Leu Lys Thr Val Gln Ala Val Leu Thr Val Pro Lys Leu Lys Leu Ser 
305                 310                 315                 320 


Tyr Glu Gly Glu Val Thr Lys Ser Leu Gln Glu Met Lys Leu Gln Ser 
                325                 330                 335     


Leu Phe Asp Ser Pro Asp Phe Ser Lys Ile Thr Gly Lys Pro Ile Lys 
            340                 345                 350         


Leu Thr Gln Val Glu His Arg Ala Gly Phe Glu Trp Asn Glu Asp Gly 
        355                 360                 365             


Ala Gly Thr Thr Pro Ser Pro Gly Leu Gln Pro Ala His Leu Thr Phe 
    370                 375                 380                 


Pro Leu Asp Tyr His Leu Asn Gln Pro Phe Ile Phe Val Leu Arg Asp 
385                 390                 395                 400 


Thr Asp Thr Gly Ala Leu Leu Phe Ile Gly Lys Ile Leu Asp Pro Arg 
                405                 410                 415     


Gly Pro 
        


<210>  4
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  4
gtgaaggtcg gtgtgaacgg                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  5
gtgatggcat ggactgtggt c                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  6
tgtggcctca ttcctcctac                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  7
tgagaatggg gacactgtga                                                   20


<210>  8
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  8
ttgccattga gaaccctg                                                     18


<210>  9
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  9
tgggatggca atgtccac                                                     18


<210>  10
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
ctcatggact gattatggac agga                                              24


<210>  11
<211>  25
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
gcaggtcagc aaagaactta tagcc                                             25


<210>  12
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
ctatgcagat catgcggatc a                                                 21


<210>  13
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  13
tatgctgcag gaagctcatc tc                                                22


