                               SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
 
<120> MODULATION OF SH2B3 TO IMPROVE RED BLOOD CELL PRODUCTION FROM 
      STEM CELLS AND/OR PROGENITOR CELLS

<130> 701039-083741-PCT

<140> PCT/US2015/062333
<141> 2015-11-24

<150> 62/083,439
<151> 2014-11-24

<160> 52    

<170> PatentIn version 3.5

<210> 1
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
ccggcctgac aacctttaca cctttctcga gaaaggtgta aaggttgtca ggtttttg         58


<210> 2
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
ccgggcctga caacctttac accttctcga gaaggtgtaa aggttgtcag gctttttg         58


<210> 3
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
gtgtgcacca ccggacctcc tgg                                               23


<210> 4
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
gctccagcat ccaggaggtc cgg                                               23


<210> 5
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(60)

<400> 5
tgc tcc agc atc cag gag gtc cgg cgg tgc aca cgg ctt gag atg cct         48
Cys Ser Ser Ile Gln Glu Val Arg Arg Cys Thr Arg Leu Glu Met Pro           
1               5                   10                  15                

gac aac ctt tac                                                         60
Asp Asn Leu Tyr                                                           
            20                                                            


<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Cys Ser Ser Ile Gln Glu Val Arg Arg Cys Thr Arg Leu Glu Met Pro 
1               5                   10                  15      


Asp Asn Leu Tyr 
            20  


<210> 7
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
tgctccagca tccaggagtc cggcggtgca cacggcttga gatgcctgac aacctttac        59


<210> 8
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
tgctccagca tccaggagtc cggcggtgca cacggcttga gatgcctgac aacctttac        59


<210> 9
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
tgctccagca tccaggagca cacggcttga gatgcctgac aacctttac                   49


<210> 10
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
tgctccagca tccagtccgg cggtgcacac ggcttgagat gcctgacaac ctttac           56


<210> 11
<211> 52
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
tgctccagca tccaggaggt gcacacggct tgagatgcct gacaaccttt ac               52


<210> 12
<211> 59
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
tgctccagca tccaggagtc cggcggtgca cacggcttga gatgcctgac aacctttac        59


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
gctccagcat ccaggaggtc                                                   20


<210> 14
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
ccaccggacc tcctggatgc tggagctg                                          28


<210> 15
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
cagctccagc atccaggagg tccggtgg                                          28


<210> 16
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 16
Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  


<210> 17
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 17
Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala 
1               5                   10                  15      


Glu Ala Leu Ala Glu Ala Leu Ala Ala Ala Ala Gly Gly Cys 
            20                  25                  30  


<210> 18
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 18
Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15  


<210> 19
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 19
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Trp Asp Tyr Gly 
            20          


<210> 20
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 20
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly 
            20              


<210> 21
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 21
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Trp Tyr Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly 
            20                  25                  30          


Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly Cys 
        35                  40                  45              


<210> 22
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 22
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Asp Gly Gly Cys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile 
            20                  25                  30          


Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Gly Cys 
        35                  40                  


<210> 23
<211> 35
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 23
Gly Leu Phe Gly Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu 
1               5                   10                  15      


His Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly 
            20                  25                  30          


Gly Ser Cys 
        35  


<210> 24
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 24
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala Gly Gly 
            20                  25                  30          


Ser Cys 
        


<210> 25
<211> 41
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide


<220>
<221> MOD_RES
<222> (17)..(17)
<223> Norleucine

<220>
<221> MOD_RES
<222> (38)..(38)
<223> Norleucine

<400> 25
Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Xaa Ile Asp Gly Lys Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu 
            20                  25                  30          


Asn Gly Trp Glu Gly Xaa Ile Asp Gly 
        35                  40      


<210> 26
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 26
Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu Leu 
1               5                   10                  15      


Leu Glu Ala 
            


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 27
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu 
1               5                   10                  15      


Leu Leu Lys Ala 
            20  


<210> 28
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 28
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Leu Arg Ala 
            20  


<210> 29
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 29
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala 
            20                  25                  30  


<210> 30
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 30
Gly Leu Phe Phe Glu Ala Ile Ala Glu Phe Ile Glu Gly Gly Trp Glu 
1               5                   10                  15      


Gly Leu Ile Glu Gly Cys 
            20          


<210> 31
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 31
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 32
His His His His His Trp Tyr Gly 
1               5               


<210> 33
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      endosomolytic/fusogenic peptide

<400> 33
Cys His Lys Lys Lys Lys Lys Lys His Cys 
1               5                   10  


<210> 34
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 34
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 35
<211> 14
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 35
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys 
1               5                   10                  


<210> 36
<211> 27
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 36
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210> 37
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 37
Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210> 38
<211> 26
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 38
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210> 39
<211> 18
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 39
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210> 40
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 40
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 41
<211> 10
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 41
Lys Phe Phe Lys Phe Phe Lys Phe Phe Lys 
1               5                   10  


<210> 42
<211> 37
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 42
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210> 43
<211> 31
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 43
Ser Trp Leu Ser Lys Thr Ala Lys Lys Leu Glu Asn Ser Ala Lys Lys 
1               5                   10                  15      


Arg Ile Ser Glu Gly Ile Ala Ile Ala Ile Gln Gly Gly Pro Arg 
            20                  25                  30      


<210> 44
<211> 30
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 44
Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210> 45
<211> 36
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 45
Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210> 46
<211> 42
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 46
Arg Arg Arg Pro Arg Pro Pro Tyr Leu Pro Arg Pro Arg Pro Pro Pro 
1               5                   10                  15      


Phe Phe Pro Pro Arg Leu Pro Pro Arg Ile Pro Pro Gly Phe Pro Pro 
            20                  25                  30          


Arg Phe Pro Pro Arg Phe Pro Gly Lys Arg 
        35                  40          


<210> 47
<211> 13
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 47
Ile Leu Pro Trp Lys Trp Pro Trp Trp Pro Trp Arg Arg 
1               5                   10              


<210> 48
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 48
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 49
<211> 11
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 49
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 50
<211> 12
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: Cell permeation peptide

<400> 50
Arg Lys Cys Arg Ile Val Val Ile Arg Val Cys Arg 
1               5                   10          


<210> 51
<211> 575
<212> PRT
<213> Homo sapiens

<400> 51
Met Asn Gly Pro Ala Leu Gln Pro Ser Ser Pro Ser Ser Ala Pro Ser 
1               5                   10                  15      


Ala Ser Pro Ala Ala Ala Pro Arg Gly Trp Ser Glu Phe Cys Glu Leu 
            20                  25                  30          


His Ala Val Ala Ala Ala Arg Glu Leu Ala Arg Gln Tyr Trp Leu Phe 
        35                  40                  45              


Ala Arg Glu His Pro Gln His Ala Pro Leu Arg Ala Glu Leu Val Ser 
    50                  55                  60                  


Leu Gln Phe Thr Asp Leu Phe Gln Arg Tyr Phe Cys Arg Glu Val Arg 
65                  70                  75                  80  


Asp Gly Arg Ala Pro Gly Arg Asp Tyr Arg Asp Thr Gly Arg Gly Pro 
                85                  90                  95      


Pro Ala Lys Ala Glu Ala Ser Pro Glu Pro Gly Pro Gly Pro Ala Ala 
            100                 105                 110         


Pro Gly Leu Pro Lys Ala Arg Ser Ser Glu Glu Leu Ala Pro Pro Arg 
        115                 120                 125             


Pro Pro Gly Pro Cys Ser Phe Gln His Phe Arg Arg Ser Leu Arg His 
    130                 135                 140                 


Ile Phe Arg Arg Arg Ser Ala Gly Glu Leu Pro Ala Ala His Thr Ala 
145                 150                 155                 160 


Ala Ala Pro Gly Thr Pro Gly Glu Ala Ala Glu Thr Pro Ala Arg Pro 
                165                 170                 175     


Gly Leu Ala Lys Lys Phe Leu Pro Trp Ser Leu Ala Arg Glu Pro Pro 
            180                 185                 190         


Pro Glu Ala Leu Lys Glu Ala Val Leu Arg Tyr Ser Leu Ala Asp Glu 
        195                 200                 205             


Ala Ser Met Asp Ser Gly Ala Arg Trp Gln Arg Gly Arg Leu Ala Leu 
    210                 215                 220                 


Arg Arg Ala Pro Gly Pro Asp Gly Pro Asp Arg Val Leu Glu Leu Phe 
225                 230                 235                 240 


Asp Pro Pro Lys Ser Ser Arg Pro Lys Leu Gln Ala Ala Cys Ser Ser 
                245                 250                 255     


Ile Gln Glu Val Arg Trp Cys Thr Arg Leu Glu Met Pro Asp Asn Leu 
            260                 265                 270         


Tyr Thr Phe Val Leu Lys Val Lys Asp Arg Thr Asp Ile Ile Phe Glu 
        275                 280                 285             


Val Gly Asp Glu Gln Gln Leu Asn Ser Trp Met Ala Glu Leu Ser Glu 
    290                 295                 300                 


Cys Thr Gly Arg Gly Leu Glu Ser Thr Glu Ala Glu Met His Ile Pro 
305                 310                 315                 320 


Ser Ala Leu Glu Pro Ser Thr Ser Ser Ser Pro Arg Gly Ser Thr Asp 
                325                 330                 335     


Ser Leu Asn Gln Gly Ala Ser Pro Gly Gly Leu Leu Asp Pro Ala Cys 
            340                 345                 350         


Gln Lys Thr Asp His Phe Leu Ser Cys Tyr Pro Trp Phe His Gly Pro 
        355                 360                 365             


Ile Ser Arg Val Lys Ala Ala Gln Leu Val Gln Leu Gln Gly Pro Asp 
    370                 375                 380                 


Ala His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg Arg Gly Glu 
385                 390                 395                 400 


Tyr Val Leu Thr Phe Asn Phe Gln Gly Ile Ala Lys His Leu Arg Leu 
                405                 410                 415     


Ser Leu Thr Glu Arg Gly Gln Cys Arg Val Gln His Leu His Phe Pro 
            420                 425                 430         


Ser Val Val Asp Met Leu His His Phe Gln Arg Ser Pro Ile Pro Leu 
        435                 440                 445             


Glu Cys Gly Ala Ala Cys Asp Val Arg Leu Ser Ser Tyr Val Val Val 
    450                 455                 460                 


Val Ser Gln Pro Pro Gly Ser Cys Asn Thr Val Leu Phe Pro Phe Ser 
465                 470                 475                 480 


Leu Pro His Trp Asp Ser Glu Ser Leu Pro His Trp Gly Ser Glu Leu 
                485                 490                 495     


Gly Leu Pro His Leu Ser Ser Ser Gly Cys Pro Arg Gly Leu Ser Pro 
            500                 505                 510         


Glu Gly Leu Pro Gly Arg Ser Ser Pro Pro Glu Gln Ile Phe His Leu 
        515                 520                 525             


Val Pro Ser Pro Glu Glu Leu Ala Asn Ser Leu Gln His Leu Glu His 
    530                 535                 540                 


Glu Pro Val Asn Arg Ala Arg Asp Ser Asp Tyr Glu Met Asp Ser Ser 
545                 550                 555                 560 


Ser Arg Ser His Leu Arg Ala Ile Asp Asn Gln Tyr Thr Pro Leu 
                565                 570                 575 


<210> 52
<211> 5425
<212> DNA
<213> Homo sapiens

<400> 52
cccgggccac cgcctccgcc cggctgcccg cccggactgt cgcggcccgc ggtggcgacg       60

gcggccgctg caaagtttcc ccggcggcgg cggcccgggg gcgcatcctc ccgcaactgt      120

caagcgctgg cggcggaaat gatgaggcgc tggccatttt ccgagcccgg gtttcctgcc      180

tgagccccgc tcgagcgagc cgcgagcgag gagccggcgg gcgggagagg acgcgcccag      240

ggcgggggcc cgcccgcccc ctcgggattt cgagggcccg ggggcgcgcg acgccatggg      300

ccggccgggc ccagagctcc tgtctctcag cccggccgca ccacctgggt ctccgccatg      360

aacgggcctg ccctgcagcc ctcctcgccc tcttccgcgc cctcagcctc cccggcggcg      420

gccccgcggg gctggagcga gttctgtgag ttgcacgccg tagcggcggc ccgggagctg      480

gcccgccagt actggctgtt cgcccgggag catccgcagc acgcgccgct gcgcgccgag      540

ctggtgtcgc tgcagttcac cgacctcttc cagcgctact tctgccgcga ggtgcgcgac      600

ggacgggcgc cgggccgcga ctaccgggac acaggccgtg ggcccccagc caaggccgag      660

gcgtccccgg agccaggccc cggccccgcc gcccctggcc tgcccaaggc ccgcagctct      720

gaggagctgg ccccgccgcg gccgcccggg ccctgctcct tccagcactt tcgccgcagc      780

ctccgccaca tcttccgccg ccgctcggcc ggggagctgc cagcggccca caccgctgcc      840

gcccccggga cccccggaga ggctgctgag acccccgccc ggcctggcct ggccaagaag      900

ttcctgccct ggagcctggc ccgggagccg ccacccgagg cgctgaagga ggcggtgctg      960

cgctacagcc tggccgacga ggcctccatg gacagcgggg cacgctggca gcgcgggagg     1020

ctggcgctgc gccgggcccc gggccccgat ggccccgacc gcgtgctgga gctcttcgac     1080

ccacccaaga gttcaaggcc caagctacaa gcagcttgct ccagcatcca ggaggtccgg     1140

tggtgcacac ggcttgagat gcctgacaac ctttacacct ttgtgctgaa ggtgaaggac     1200

cggacagaca tcatctttga ggtgggagac gagcagcagc tgaattcatg gatggctgag     1260

ctctcggagt gcacaggccg agggctggag agcacagaag cagagatgca tattccctca     1320

gccctagagc ctagcacgtc cagctcccca aggggcagca cagattccct taaccaaggt     1380

gcttctcctg gggggctgct ggacccggcc tgccagaaga cggaccattt cctgtcctgc     1440

tacccctggt tccacggccc catctccaga gtgaaagcag ctcagctggt tcagctgcag     1500

ggccctgatg ctcatggagt gttcctggtg cggcagagcg agacgcggcg tggggaatac     1560

gtgctcactt tcaactttca ggggatagcc aagcacctgc gcctgtcgct gacagagcgg     1620

ggccagtgcc gtgtgcagca cctccacttt ccctcggtcg tggacatgct ccaccacttc     1680

cagcgctcgc ccatcccact cgagtgcggc gccgcctgtg atgtccggct ctccagctac     1740

gtggtagtcg tctcccaacc accaggttcc tgcaacacgg tcctcttccc tttctccctt     1800

cctcactggg attcagagtc ccttcctcac tggggttcag agttgggcct tccccacctt     1860

agttcttctg gctgtccccg ggggctcagc ccagagggtc tcccagggcg atcctcaccc     1920

cccgagcaga tcttccacct ggtgccttcg cccgaagaac tggccaacag cctgcagcac     1980

ctggagcatg agcctgtgaa tcgagcccgg gactcggact acgaaatgga ctcatcctcc     2040

cggagccacc tgcgggccat agacaatcag tacacacctc tctgaccagt gaggaattcc     2100

aggcctcaac agctgccctt gaggagcaca ggcagaagtg tgaacttgtg aatgtaattg     2160

atctttcctt ccttccagag aaagatttaa gggacactgt taactgctcg tgccagtttg     2220

gaagtgaccc ttctattagg cctgttgaag ggccctcctg taggtttcat ctatccacct     2280

ggctttctcc ttattgttta cagatgtagt tcttgttaga ggatgccgct agctcctgcc     2340

cggggtccct atgcccagtc cccgttactc ttagagaaag gagttggggt gagggccaga     2400

gctggcagtg gaaacttgtt ctctttttca ctgacactgt cacagcggat gacagacttt     2460

ctacggggag gaggggggga tcatcaggaa gcccagaaca ctaacaagcg gttctcccat     2520

ctaccgtcag tccacatggc aggtctgctg tgtccacacc acagatgacc acatctaatc     2580

ctgcttctac tctcagcttt aggacaaaag ctctgtcaga ggcacaagct gaaggtcaaa     2640

aatgatttaa aacattttac ctcagactaa tttctttaaa ggattcaggt tcaaaactta     2700

accactgctt atttcagtgc actgtttcaa ctaacaccca tgctattttt gtagtcagaa     2760

acagctatgc aaaccctacc taatttacag tctgagccag catgctggct tgtctactgc     2820

atcctcggga cagtcacctg ccactgagtg gccactgtcc ttcctaaatg tcaagaagtg     2880

aagtatgtca ccctttcagg gaaattcagg caattactga aataggaggg tggcaagaac     2940

agttctatcc tggtgcctta cgaataaaaa actggattct ggtttacagc agctttacag     3000

tgatagttaa attaactggg gctaggggaa gagcaagcaa aaagggaaga aggactccta     3060

ggccctttct agtaaatcct tcagcaacaa ggctggcttg gtgccctcca agcatctaat     3120

ggcttattaa attatcccac aagtgggttt taggctcctt ttttgagcca aaatggaagc     3180

tgggaatctg gtgccataac taatgagaaa ctcctttaat agcccacaat cagtgttctg     3240

ttctagctgg ctactgcttc actggattga gaatctatct atctccttgc acacatgggc     3300

acacacaatc tccaccatcc agggaggtcc tgaagtcaaa tctctatcta tacaagtgat     3360

acaattcata gggggctggc tcctcccaga acctgtctgg aggctcagaa acgggggcag     3420

tgacagtgga gtcagctgct cttgggtgcc agcagagcca ttcagtacaa cccccaggct     3480

cacagcagtg gcttctagga aactgggagt ttagatcagc tttacagata catcgatcag     3540

aggctaaaat gaaacctcag cctaaaactc ataggactga ctgcctggga ggagggttag     3600

gtctgcttct tccacttata cttagtctct gtgctccaag aggtcaaatt tttgcttcta     3660

gaatttcctt ggggtctttc agagggtggg ggaacaaacc cctatgcact tttctttttt     3720

ttttttttga gatggagttt ctcttgtcaa ccgggctgga gtgcagtggt gcaatcttgg     3780

ctcactgcaa cctccacctt cctggttcaa gcgattctgc ctcgacctct caagtagctg     3840

ggattacaag caccagccac catgcctggc taattttgta tttttagtag agacagggtt     3900

tcaccatgtt ggccaggctg gtctcgaatg tctgacctca ggtgatccac ccgccttggc     3960

ctcccaaagt gctgggatta caggcgcgag ccaccgcgcc cagcctacac cacttttagt     4020

accaacactc ttgggtgatt tcatggaccc taaagcagac ctgacactga tccagatttg     4080

cagtccattt ttaaggacac ctgtctttat ttcctcaaag tcaagcagct ttctctggaa     4140

aatgaatgct aattagtgtg aaccaaaaga gtaagtaaga gtctgaagtt tttttaaagg     4200

agaaagctta ttatggaaag tcactggtcc tcccctccgc acaggaaagg tacccagtag     4260

ataatgaacc aaattaagtt ccctccctcc agccagaagt taaacatctg ggatatgacg     4320

tcttcatgcc aggggcactc atttcttagc agcctctcta catacatctc tcaggtggtg     4380

ccaagaggca caccaggtag agcaaactta gcagctctga ctaacaggct gcaaagtgca     4440

agttcagatt ctgtggcaga gatttggaag gcacccacct ccagactgct tcccgtccaa     4500

gttaccagga cagctcaaaa acatgctgac agaaaactcc catggctcta ggaagaagtg     4560

acactaagcc aacacctttc tttatgtggg agcagaatca gctgatgaag gggtgggcag     4620

cagtgtgggg caggcacccc actggctgca gctagcccac cataggcaca gcacatccca     4680

ccactctcct tccagtcctg accaggcccc agccggcaac ttctaccgag agccatggct     4740

caacaccaaa ctggacagta gacatcatga tccctccagt tagctctaat tacagacccc     4800

accagtacag cttgacagct cccggcacca tcccttcctt catctgactt attgaacttt     4860

tacaaactaa cagtcaccag caccaaagaa ttaagtcaac taacctgcct tgaattttag     4920

accagcaatc catatggctt tatctggtat aaatcttctg cctttgatca tttctggacc     4980

gtaggaaaaa ggaatagcaa tcattaaaat cttgggccag agaacactat ttttacataa     5040

cagtttctta acctaaagtc aaggccttgg actcttccct gagggttgcc tgagattcct     5100

tcatgctttc tattcaggac taagtccctt actgcaaatg tgttagctct aacatctccc     5160

acaagctaga ggaacttgcg agtatattaa caaggacaca tctgacatcc tgtgtttggt     5220

tagaatatac agcacattgt gataacataa agtggattca tcttgtatca ttataggcag     5280

aaggtatttg gcaaattttt atgtattgtt ttatgtactg tacaagtaac ttattcttga     5340

ataatgcaaa ttttgctata atgtacaaat tgctatatgt gaattaaaaa gttttcagaa     5400

tcttgaaaaa aaaaaaaaaa aaaaa                                           5425


