﻿               SEQUENCE LISTING

<110> Guerra Emanuela
      Alberti Saverio

<120> Humanized anti-Trop-2 monoclonal antibodies and uses thereof

<130> PCT Alberti-Guerra

<150> IT2014A000032
<151> 2014-12-04

<160> 92

<170> BiSSAP 1.3

<210> 1
<211> 5
<212> PRT
<213> Mus musculus

<220> 
<223> CDR

<400> 1
Asn Tyr Trp Ile Gly 
1               5   

<210> 2
<211> 17
<212> PRT
<213> Mus musculus

<220> 
<223> CDR

<400> 2
Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 3
<211> 7
<212> PRT
<213> Mus musculus

<400> 3
Gly Thr Gly Gly Gly Asp Tyr 
1               5           

<210> 4
<211> 15
<212> PRT
<213> Mus musculus

<400> 4
Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Ser Tyr Met His 
1               5                   10                  15  

<210> 5
<211> 7
<212> PRT
<213> Mus musculus

<400> 5
Tyr Ala Ser Asn Leu Glu Ser 
1               5           

<210> 6
<211> 9
<212> PRT
<213> Mus musculus

<400> 6
Gln His Ser Trp Glu Ile Pro Tyr Thr 
1               5                   

<210> 7
<211> 5
<212> PRT
<213> Mus musculus

<400> 7
Ser Ser Tyr Ile Ser 
1               5   

<210> 8
<211> 17
<212> PRT
<213> Mus musculus

<400> 8
Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn Gln Lys Phe Thr 
1               5                   10                  15      
Gly 
    

<210> 9
<211> 10
<212> PRT
<213> Mus musculus

<400> 9
His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr 
1               5                   10  

<210> 10
<211> 11
<212> PRT
<213> Mus musculus

<400> 10
Ile Thr Ser Thr Asp Ile Asp Asp Asp Met Asn 
1               5                   10      

<210> 11
<211> 7
<212> PRT
<213> Mus musculus

<400> 11
Glu Gly Asn Thr Leu Arg Pro 
1               5           

<210> 12
<211> 9
<212> PRT
<213> Mus musculus

<400> 12
Leu Gln Ser Asp Asn Leu Pro Tyr Thr 
1               5                   

<210> 13
<211> 405
<212> DNA
<213> Mus musculus

<400> 13
atggaatgga gcggggtctt tatctttctc ctgtcagtga ctgcaggcgt ccactcccaa      60

gtccagctcc agcagtctgg agctgagctc gtgaggcctg ggacttcagt gaagatgtcc     120

tgcaaggctg ctggatacac cttcactaac tactggatcg gatgggtgaa gcagaggcct     180

ggacatggcc tcgagtggat tggagatatt taccctggag gaggctatac taactacaat     240

gagaagttca agggcaaggc cacactgact gcagacacat cctccagcac agcctacatg     300

cagctcagca gcctgacatc tgaggactct gccatctatt actgtgcaag aggaactgga     360

ggcggagact actggggcca agggactctg gtcactgtct ctgca                     405


<210> 14
<211> 135
<212> PRT
<213> Mus musculus

<400> 14
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          
Pro Gly Thr Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Trp Ile Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      
Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Thr Gly Gly Gly Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             
Thr Leu Val Thr Val Ser Ala 
    130                 135 

<210> 15
<211> 393
<212> DNA
<213> Mus musculus

<400> 15
atggagacag acacactcct gctatgggtg ctgctgctct gggttccagg ttccactggt      60

gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc     120

atctcatgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac     180

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct     240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat     300

cctgtggagg aggaggatac tgcaacatat tactgtcagc acagttggga gattccgtac     360

acgttcggag gggggaccaa gctggaaata aaa                                  393


<210> 16
<211> 131
<212> PRT
<213> Mus musculus

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          
Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  
Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Asn Ile His Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys 
            100                 105                 110         
Gln His Ser Trp Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys 
    130     

<210> 17
<211> 414
<212> DNA
<213> Mus musculus

<400> 17
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctattcccag      60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gaagctgtcc     120

tgcaagactt ctggcttcac cttcagcagt agctatataa gttggttgaa gcagaagcct     180

cgacagagtc ttgagtggat tgcatggatt tatgctggaa ctggtggtac tagctataat     240

cagaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg     300

caactcagca gcctgacatc tgaggactct gccatctatt actgtgcaag acataaccct     360

cgttactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca           414


<210> 18
<211> 138
<212> PRT
<213> Mus musculus

<400> 18
Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      
Val Tyr Ser Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Ser Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu 
    50                  55                  60                  
Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      
Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         
Tyr Tyr Cys Ala Arg His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135             

<210> 19
<211> 381
<212> DNA
<213> Mus musculus

<400> 19
atgttctcac tagctcttct cctcagtctt cttctcctct gtgtctctga ttctagggca      60

gaaacaactg tgacccagtc tccagcatcc ctgtccatgg ctataggaga aaaagtcacc     120

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca     180

ggggaacctc ctaagctcct tatttcagaa ggcaatactc ttcgtcctgg agtcccatcc     240

cgattctcca gcagtggcta tggtacagat tttgttttta caattgaaaa catgctctca     300

gaagatgttg cagattacta ctgtttgcaa agtgataact tgccgtacac gttcggaggg     360

gggaccaagc tggaaataaa a                                               381


<210> 20
<211> 127
<212> PRT
<213> Mus musculus

<400> 20
Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Asp Ser Arg Ala Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          
Met Ala Ile Gly Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp 
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro 
    50                  55                  60                  
Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu 
                85                  90                  95      
Asn Met Leu Ser Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         
Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         

<210> 21
<211> 405
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VH 

<400> 21
atggaatgga gcggggtctt tatctttctc ctgtcagtga ctgcaggcgt ccactcccaa      60

gtccagctcg tgcagtctgg agctgaagtg aagaaacctg gggcttcagt gaaggtgtcc     120

tgcaaggctt ctggatacac cttcactaac tactggatcg gatgggtcag acaggcccct     180

ggacagggcc tcgagtggat tggagatatt taccctggag gaggctatac taactacaat     240

gagaagttca agggcagagc cacactgact gcagacacat ccgccagcac agcctacatg     300

gagctcagca gcctgagatc tgaggacact gccgtgtatt actgtgcaag aggaactgga     360

ggcggagact actggggcca agggactctg gtcactgtct cttca                     405


<210> 22
<211> 135
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VH 

<400> 22
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Thr Gly Gly Gly Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser 
    130                 135 

<210> 23
<211> 405
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VH

<400> 23
atggaatgga gcggggtctt tatctttctc ctgtcagtga ctgcaggcgt ccactcccaa      60

gtccagctcg tgcagtctgg agctgaagtg aagaaacctg gggcttcagt gaaggtgtcc     120

tgcaaggctt ctggatacac cttcactaac tactggatcg gatgggtcag acaggcccct     180

ggacagggcc tcgagtggat tggagatatt taccctggag gaggctatac taactacaat     240

gagaagttca agggcagagc cacactgact gcagacacat ccaccagcac agcctacatg     300

gagctcagca gcctgagatc tgaggacact gccgtgtatt actgtgcaag aggaactgga     360

ggcggagact actggggcca agggactctg gtcactgtct cttca                     405


<210> 24
<211> 135
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VH

<400> 24
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Trp Ile Gly Trp Val Arg Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Thr Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Thr Gly Gly Gly Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser 
    130                 135 

<210> 25
<211> 405
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VH

<400> 25
atggaatgga gcggggtctt tatctttctc ctgtcagtga ctgcaggcgt ccactcccaa      60

gtccagctcg tgcagtctgg agctgaagtg aagaaacctg gggcttcagt gaaggtgtcc     120

tgcaaggctt ctggatacac cttcactaac tactggatcg gatgggtcag acaggcccct     180

ggacagggcc tcgagtggat tggagatatt taccctggag gaggctatac taactacaat     240

gagaagttca agggcagagc cacactgact gcagacacat ccaccagcac agcctacatg     300

gagctcagca gcctgagatc tgaggacact gccgtgtatt actgtgcaag aggaactgga     360

ggcggagact actggggcca agggactctg gtcactgtct cttca                     405


<210> 26
<211> 135
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VH

<400> 26
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Trp Ile Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Thr Gly Gly Gly Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser 
    130                 135 

<210> 27
<211> 394
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VL

<400> 27
atggagacag acacactcct gctgtgggtg ctgctgctct gggttccagg ctccactggc      60

gacattgtga tgacacagtc tcctgactcc ctggctgtgt ctctggggga gagggccacc     120

atcaactgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac     180

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctggaatct     240

ggggtccctg acagattcag tggcagtggg tctgggacag acttcaccct caccatcagc     300

tccctgcagg ccgaggatgt ggcagtctat tactgtcagc acagttggga gattccctac     360

accttcggac aggggaccaa gctggaaatc aaac                                 394


<210> 28
<211> 131
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VL

<400> 28
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          
Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            100                 105                 110         
Gln His Ser Trp Glu Ile Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys 
    130     

<210> 29
<211> 394
<212> DNA
<213> Artificial sequence

<220> 
<223> Hunanized VL 

<400> 29
atggagacag acacactcct gctgtgggtg ctgctgctct gggttccagg ctccactggc      60

gacattgtgc tgacacagtc tcctgactcc ctggctgtgt ctctggggga gagggccacc     120

atcaactgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac     180

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctggaatct     240

ggggtccctg acagattcag tggcagtggg tctgggacag acttcaccct caccatcagc     300

tccctgcagg ccgaggatgt ggcagtctat tactgtcagc acagttggga gattccctac     360

accttcggag gcgggaccaa gctggaaatc aaac                                 394


<210> 30
<211> 131
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 30
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          
Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            100                 105                 110         
Gln His Ser Trp Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys 
    130     

<210> 31
<211> 414
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VH 

<400> 31
atggaatgga actgggtcgt tctcttcctc ctgtcactga ctgcaggcgt ctattcccaa      60

gtgcagctcg tccagtctgg agctgaagtc aaaaagcctg gggcttcagt gaaagtctcc     120

tgcaaggctt ctggcttcac cttcagcagt agctatatca gttggttgag gcaggcccct     180

ggacagagac ttgagtggat tgcatggatt tatgctggaa ctggcggaac tagctataat     240

cagaagttca caggcaaggc cacactgact gtagacacat ccgccagcac agcctacatg     300

gaactcagca gcctgagatc tgaggacact gccgtctatt actgtgcaag acataaccct     360

cgttactatg ctatggacta ctggggccaa ggaaccacag tcaccgtctc ctca           414


<210> 32
<211> 138
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VH 

<400> 32
Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      
Val Tyr Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Ser Tyr Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  
Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135             

<210> 33
<211> 414
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VH 

<400> 33
atggaatgga actgggtcgt tctcttcctc ctgtcactga ctgcaggcgt ctattcccaa      60

gtgcagctcg tccagtctgg agctgaagtc aaaaagcctg gggcttcagt gaaagtctcc     120

tgcaaggctt ctggcttcac cttcagcagt agctatatca gttggttgag gcaggcccct     180

ggacagagac ttgagtggat tgcatggatt tatgctggaa ctggcggaac tagctataat     240

cagaagttca caggcagagt cacactgact gtagacacat ccgccagcac agcctacatg     300

gaactcagca gcctgagatc tgaggacact gccgtctatt actgtgcaag acataaccct     360

cgttactatg ctatggacta ctggggccaa ggaaccacag tcaccgtctc ctca           414


<210> 34
<211> 138
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VH 

<400> 34
Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      
Val Tyr Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Ser Tyr Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  
Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Thr Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135             

<210> 35
<211> 382
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 35
atgttctcac tggctctgct cctcagtctg ctgctcctct gtgtctctga ttctagagca      60

gacatccaga tgacccagtc tccaagctcc ctgtccgcca gcgtgggaga tagagtcacc     120

atcacatgca tcaccagcac tgatattgat gatgatatga actggtacca gcagaagcca     180

gggaaagctc ctaagctcct gatttcagaa ggcaatactc tgcgccctgg agtcccatcc     240

cgattctccg gcagtggcta tggaacagat tttaccttta caattagctc cctgcagcca     300

gaagatattg caacctacta ctgtttgcaa agtgataacc tgccctacac cttcggaggg     360

gggaccaaag tcgaaatcaa ac                                              382


<210> 36
<211> 127
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 36
Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Asp Ser Arg Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp 
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         
Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         

<210> 37
<211> 382
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 37
atgttctcac tggctctgct cctcagtctg ctgctcctct gtgtctctga ttctagagca      60

gacatccaga tgacccagtc tccaagctcc ctgtccgcca gcgtgggaga tagagtcacc     120

atcacatgca tcaccagcac tgatattgat gatgatatga actggtacca gcagaagcca     180

gggaaagctc ctaagctcct gatttcagaa ggcaatactc tgcgccctgg agtcccatcc     240

cgattctccg gcagtggctc tggaacagat tttaccttta caattagctc cctgcagcca     300

gaagatattg caacctacta ctgtttgcaa agtgataacc tgccctacac cttcggaggg     360

gggaccaaag tcgaaatcaa ac                                              382


<210> 38
<211> 127
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 38
Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Asp Ser Arg Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp 
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         
Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         

<210> 39
<211> 382
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 39
atgttctcac tggctctgct cctcagtctg ctgctcctct gtgtctctga ttctagagca      60

gacacccaga tgacccagtc tccaagctcc ctgtccgcca gcgtgggaga tagagtcacc     120

atcacatgca tcaccagcac tgatattgat gatgatatga actggtacca gcagaagcca     180

gggaaagctc ctaagctcct gatttcagaa ggcaatactc tgcgccctgg agtcccatcc     240

cgattctccg gcagtggcta tggaacagat tttaccttta caattagctc cctgcagcca     300

gaagatattg caacctacta ctgtttgcaa agtgataacc tgccctacac cttcggaggg     360

gggaccaaag tcgaaatcaa ac                                              382


<210> 40
<211> 127
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized VL 

<400> 40
Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Asp Ser Arg Ala Asp Thr Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp 
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         
Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125         

<210> 41
<211> 1398
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 41
atggaatgga gcggggtctt tatctttctc ctgtcagtga ctgcaggcgt ccactcccaa      60

gtccagctcg tgcagtctgg agctgaagtg aagaaacctg gggcttcagt gaaggtgtcc     120

tgcaaggctt ctggatacac cttcactaac tactggatcg gatgggtcaa acaggcccct     180

ggacagggcc tcgagtggat tggagatatt taccctggag gaggctatac taactacaat     240

gagaagttca agggcagagc cacactgact gcagacacat ccgccagcac agcctacatg     300

gagctcagca gcctgagatc tgaggacact gccgtgtatt actgtgcaag aggaactgga     360

ggcggagact actggggcca agggactctg gtcactgtct cttcagcctc caccaagggc     420

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg     480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc     540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc     600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg     660

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa     720

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc     780

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     840

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     900

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     960

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag    1020

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag    1080

ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag    1140

gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag    1200

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc    1260

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc    1320

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc    1380

ctgtctccgg gtaaatga                                                  1398


<210> 42
<211> 465
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 42
Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              
Thr Asn Tyr Trp Ile Gly Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
    50                  55                  60                  
Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Thr Asn Tyr Asn 
65                  70                  75                  80  
Glu Lys Phe Lys Gly Arg Ala Thr Leu Thr Ala Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg Gly Thr Gly Gly Gly Asp Tyr Trp Gly Gln Gly 
        115                 120                 125             
Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
    130                 135                 140                 
Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
145                 150                 155                 160 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
                165                 170                 175     
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
            180                 185                 190         
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
        195                 200                 205             
Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
    210                 215                 220                 
Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
225                 230                 235                 240 
Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 
Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     
Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         
Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             
Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 
Lys 
465 

<210> 43
<211> 717
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 43
atggagacag acacactcct gctgtgggtg ctgctgctct gggttccagg ctccactggc      60

gacattgtgc tgacacagtc tcctgactcc ctggctgtgt ctctggggga gagggccacc     120

atcaactgca gggccagcca aagtgtcagt acatctagct atagttatat gcactggtac     180

caacagaaac caggacagcc acccaaactc ctcatcaagt atgcatccaa cctggaatct     240

ggggtccctg acagattcag tggcagtggg tctgggacag acttcaccct caccatcagc     300

tccctgcagg ccgaggatgt ggcagtctat tactgtcagc acagttggga gattccctac     360

accttcggag gcgggaccaa gctggaaatc aaacgaactg tggctgcacc atctgtcttc     420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg     480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg     540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc     600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc     660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag        717


<210> 44
<211> 238
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 44
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      
Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala 
            20                  25                  30          
Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser 
        35                  40                  45              
Val Ser Thr Ser Ser Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  
Gly Gln Pro Pro Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      
Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
            100                 105                 110         
Gln His Ser Trp Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             

<210> 45
<211> 1407
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 45
atggaatgga actgggtcgt tctcttcctc ctgtcactga ctgcaggcgt ctattcccaa      60

gtgcagctcg tccagtctgg agctgaagtc aaaaagcctg gggcttcagt gaaagtctcc     120

tgcaaggctt ctggcttcac cttcagcagt agctatatca gttggttgag gcaggcccct     180

ggacagagac ttgagtggat tgcatggatt tatgctggaa ctggcggaac tagctataat     240

cagaagttca caggcaaggc cacactgact gtagacacat ccgccagcac agcctacatg     300

gaactcagca gcctgagatc tgaggacact gccgtctatt actgtgcaag acataaccct     360

cgttactatg ctatggacta ctggggccaa ggaaccacag tcaccgtctc ctcagcctcc     420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct     720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc    1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc    1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg    1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac    1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag    1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag    1380

agcctctccc tgtctccggg taaatga                                        1407


<210> 46
<211> 468
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 46
Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      
Val Tyr Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Ser Tyr Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  
Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Thr Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 47
<211> 705
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 47
atgttctcac tggctctgct cctcagtctg ctgctcctct gtgtctctga ttctagagca      60

gacacccaga tgacccagtc tccaagctcc ctgtccgcca gcgtgggaga tagagtcacc     120

atcacatgca tcaccagcac tgatattgat gatgatatga actggtacca gcagaagcca     180

gggaaagctc ctaagctcct gatttcagaa ggcaatactc tgcgccctgg agtcccatcc     240

cgattctccg gcagtggcta tggaacagat tttaccttta caattagctc cctgcagcca     300

gaagatattg caacctacta ctgtttgcaa agtgataacc tgccctacac cttcggaggg     360

gggaccaaag tcgaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 48
<211> 234
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 48
Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Asp Ser Arg Ala Asp Thr Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          
Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ile Thr Ser Thr Asp 
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  
Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      
Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         
Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 49
<211> 1407
<212> DNA
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 49
atggaatgga actgggtcgt tctcttcctc ctgtcactga ctgcaggcgt ctattcccaa      60

gtgcagctcg tccagtctgg agctgaagtc aaaaagcctg gggcttcagt gaaagtctcc     120

tgcaaggctt ctggcttcac cttcagcagt agctatatca gttggttgag gcaggcccct     180

ggacagagac ttgagtggat tgcatggatt tatgctggaa ctggcggaac tagctataat     240

cagaagttca caggcagagt cacactgact gtagacacat ccgccagcac agcctacatg     300

gaactcagca gcctgagatc tgaggacact gccgtctatt actgtgcaag acataaccct     360

cgttactatg ctatggacta ctggggccaa ggaaccacag tcaccgtctc ctcagcctcc     420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct     720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc    1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc    1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg    1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac    1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag    1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag    1380

agcctctccc tgtctccggg taaatga                                        1407


<210> 50
<211> 468
<212> PRT
<213> Artificial sequence

<220> 
<223> Humanized IgG 

<400> 50
Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      
Val Tyr Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Ser Tyr Ile Ser Trp Leu Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  
Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Thr Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ala Ser 
                85                  90                  95      
Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         
Tyr Tyr Cys Ala Arg His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 51
<211> 21
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 51
tacaccttca ctaactactg g                                              21


<210> 52
<211> 18
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 52
cccagttcct ctgcacag                                                  18


<210> 53
<211> 20
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 53
gccagtggat agactgatgg                                                20


<210> 54
<211> 20
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 54
agccaaagtg tcagtacatc                                                20


<210> 55
<211> 29
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 55
ctccctctaa cactcattcc tgttgaagc                                      29


<210> 56
<211> 19
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 56
gaatctcccg actgtgctg                                                 19


<210> 57
<211> 443
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene
<400> 57
actagtgcca ccatggaatg gagcggggtc tttatctttc tcctgtcagt gactgcaggc      60

gtccactccc aagtccagct ccagcagtct ggagctgagc tcgtgaggcc tgggacttca     120

gtgaagatgt cctgcaaggc tgctggatac accttcacta actactggat cggatgggtg     180

aagcagaggc ctggacatgg cctcgagtgg attggagata tttaccctgg aggaggctat     240

actaactaca atgagaagtt caagggcaag gccacactga ctgcagacac atcctccagc     300

acagcctaca tgcagctcag cagcctgaca tctgaggact ctgccatcta ttactgtgca     360

agaggaactg gaggcggaga ctactggggc caagggactc tggtcactgt ctctgcaggt     420

gagtcctaac ttctcccaag ctt                                             443


<210> 58
<211> 430
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 58
gctagcgcca ccatggagac agacacactc ctgctgtggg tgctgctgct ctgggttcca      60

ggctccactg gcgacattgt gctgacacag tctcctgctt ccctggctgt gtctctgggg     120

cagagggcca ccatctcatg cagggccagc caaagtgtca gtacatctag ctatagttat     180

atgcactggt accaacagaa accaggacag ccacccaaac tcctcatcaa gtatgcatcc     240

aacctggaat ctggggtccc tgccagattc agtggcagtg ggtctgggac agacttcacc     300

ctcaacatcc atcctgtgga ggaggaggat actgcaacat attactgtca gcacagttgg     360

gagattccct acaccttcgg aggggggacc aagctggaaa tcaaacgtaa gtagtcttct     420

caacgaattc                                                            430


<210> 59
<211> 443
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 59
actagtgcca ccatggaatg gagcggggtc tttatctttc tcctgtcagt gactgcaggc      60

gtccactccc aagtccagct cgtgcagtct ggagctgaag tgaagaaacc tggggcttca     120

gtgaaggtgt cctgcaaggc ttctggatac accttcacta actactggat cggatgggtc     180

agacaggccc ctggacaggg cctcgagtgg attggagata tttaccctgg aggaggctat     240

actaactaca atgagaagtt caagggcaga gccacactga ctgcagacac atccgccagc     300

acagcctaca tggagctcag cagcctgaga tctgaggaca ctgccgtgta ttactgtgca     360

agaggaactg gaggcggaga ctactggggc caagggactc tggtcactgt ctcttcaggt     420

gagtcctaac ttctcccaag ctt                                             443


<210> 60
<211> 443
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 60
actagtgcca ccatggaatg gagcggggtc tttatctttc tcctgtcagt gactgcaggc      60

gtccactccc aagtccagct cgtgcagtct ggagctgaag tgaagaaacc tggggcttca     120

gtgaaggtgt cctgcaaggc ttctggatac accttcacta actactggat cggatgggtc     180

agacaggccc ctggacaggg cctcgagtgg attggagata tttaccctgg aggaggctat     240

actaactaca atgagaagtt caagggcaga gccacactga ctgcagacac atccaccagc     300

acagcctaca tggagctcag cagcctgaga tctgaggaca ctgccgtgta ttactgtgca     360

agaggaactg gaggcggaga ctactggggc caagggactc tggtcactgt ctcttcaggt     420

gagtcctaac ttctcccaag ctt                                             443


<210> 61
<211> 430
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 61
gctagcgcca ccatggagac agacacactc ctgctgtggg tgctgctgct ctgggttcca      60

ggctccactg gcgacattgt gatgacacag tctcctgact ccctggctgt gtctctgggg     120

gagagggcca ccatcaactg cagggccagc caaagtgtca gtacatctag ctatagttat     180

atgcactggt accaacagaa accaggacag ccacccaaac tcctcatcaa gtatgcatcc     240

aacctggaat ctggggtccc tgacagattc agtggcagtg ggtctgggac agacttcacc     300

ctcaccatca gctccctgca ggccgaggat gtggcagtct attactgtca gcacagttgg     360

gagattccct acaccttcgg acaggggacc aagctggaaa tcaaacgtaa gtagtcttct     420

caacgaattc                                                            430


<210> 62
<211> 24
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 62
gaaccgtcag atcgcctgga gacg                                           24


<210> 63
<211> 20
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 63
tgaaagatga gctggaggac                                                20


<210> 64
<211> 20
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 64
ctttcttgtc caccttggtg                                                20


<210> 65
<211> 17
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 65
gctgtcctac agtcctc                                                   17


<210> 66
<211> 18
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 66
acgtgccaag catcctcg                                                  18


<210> 67
<211> 443
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 67
actagtgcca ccatggaatg gagcggggtc tttatctttc tcctgtcagt gactgcaggc      60

gtccactccc aagtccagct cgtgcagtct ggagctgaag tgaagaaacc tggggcttca     120

gtgaaggtgt cctgcaaggc ttctggatac accttcacta actactggat cggatgggtc     180

agacaggccc ctggacaggg cctcgagtgg attggagata tttaccctgg aggaggctat     240

actaactaca atgagaagtt caagggcaga gccacactga ctgcagacac atccaccagc     300

acagcctaca tggagctcag cagcctgaga tctgaggaca ctgccgtgta ttactgtgca     360

agaggaactg gaggcggaga ctactggggc caagggactc tggtcactgt ctcttcaggt     420

gagtcctaac ttctcccaag ctt                                             443


<210> 68
<211> 430
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 68
gctagcgcca ccatggagac agacacactc ctgctgtggg tgctgctgct ctgggttcca      60

ggctccactg gcgacattgt gctgacacag tctcctgact ccctggctgt gtctctgggg     120

gagagggcca ccatcaactg cagggccagc caaagtgtca gtacatctag ctatagttat     180

atgcactggt accaacagaa accaggacag ccacccaaac tcctcatcaa gtatgcatcc     240

aacctggaat ctggggtccc tgacagattc agtggcagtg ggtctgggac agacttcacc     300

ctcaccatca gctccctgca ggccgaggat gtggcagtct attactgtca gcacagttgg     360

gagattccct acaccttcgg aggcgggacc aagctggaaa tcaaacgtaa gtagtcttct     420

caacgaattc                                                            430


<210> 69
<211> 20
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 69
gccagtggat agaccgatgg                                                20


<210> 70
<211> 19
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 70
accagcactg atattgatg                                                 19


<210> 71
<211> 20
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 71
cgtgtacggc aagttatcac                                                20


<210> 72
<211> 449
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene

<400> 72
actagtacca ccatggaatg gaactgggtc gttctcttcc tcctgtcatt aactgcaggt      60

gtctattccc agggtcagat gcagcagtct ggagctgagc tggtgaagcc tggggcttca     120

gtgaagctgt cctgcaagac ttctggcttc accttcagca gtagctatat aagttggttg     180

aagcagaagc ctcgacagag tcttgagtgg attgcatgga tttatgctgg aactggtggt     240

actagctata atcagaagtt cacaggcaag gcccaactga ctgtagacac atcctccagc     300

acagcctaca tgcaactcag cagcctgaca tctgaggact ctgccatcta ttactgtgca     360

agacataacc ctcgttacta tgctatggac tactggggtc aaggaacctc agtcaccgtc     420

tcctcaggta agaatggcct ctcaagctt                                       449


<210> 73
<211> 33
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 73
gcaactagta ccaccatgga atggaactgg gtc                                  33


<210> 74
<211> 47
<212> DNA
<213> Artificial sequence

<220> 
<223> oligonucleotide

<400> 74
gggaagcttg agaggccatt cttacctgag gagacggtga ctgaggt                   47


<210> 75
<211> 416
<212> DNA
<213> Artificial sequence

<220> 
<223> Synthetic gene
<400> 75
gctagcacca ccatgttctc actagctctt ctcctcagtc ttcttctcct ctgtgtctct      60

gattctaggg cagaaacaac tgtgacccag tctccagcat ccctgtccat ggctatagga     120

gaaaaagtca ccatcagatg cataaccagc actgatattg atgatgatat gaactggtac     180

cagcagaagc caggggaacc tcctaagctc cttatttcag aaggcaatac tcttcgtcct     240

ggagtcccat cccgattctc cagcagtggc tatggtacag attttgtttt tacaattgaa     300

aacatgctct cagaagatgt tgcagattac tactgtttgc aaagtgataa cttgccgtac     360

acgttcggag gggggaccaa gctggaaatc aaacgtaagt agaatccaaa gaattc         416


<210> 76
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide

<400> 76
gctgctagca ccaccatgtt ctcactagct cttctcc                              37


<210> 77
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> oligonucleotide

<400> 77
cgagaattct ttggattcta cttacgtttg atttccagct tggtc                     45


<210> 78
<211> 449
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic gene

<400> 78
actagtacca ccatggaatg gaactgggtc gttctcttcc tcctgtcact gactgcaggc      60

gtctattccc aagtgcagct cgtccagtct ggagctgaag tcaaaaagcc tggggcttca     120

gtgaaagtct cctgcaaggc ttctggcttc accttcagca gtagctatat cagttggttg     180

aggcaggccc ctggacagag acttgagtgg attgcatgga tttatgctgg aactggcgga     240

actagctata atcagaagtt cacaggcaag gccacactga ctgtagacac atccgccagc     300

acagcctaca tggaactcag cagcctgaga tctgaggaca ctgccgtcta ttactgtgca     360

agacataacc ctcgttacta tgctatggac tactggggcc aaggaaccac agtcaccgtc     420

tcctcaggta agaatggcct ctcaagctt                                       449


<210> 79
<211> 449
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic gene

<400> 79
actagtacca ccatggaatg gaactgggtc gttctcttcc tcctgtcact gactgcaggc      60

gtctattccc aagtgcagct cgtccagtct ggagctgaag tcaaaaagcc tggggcttca     120

gtgaaagtct cctgcaaggc ttctggcttc accttcagca gtagctatat cagttggttg     180

aggcaggccc ctggacagag acttgagtgg attgcatgga tttatgctgg aactggcgga     240

actagctata atcagaagtt cacaggcaga gtcacactga ctgtagacac atccgccagc     300

acagcctaca tggaactcag cagcctgaga tctgaggaca ctgccgtcta ttactgtgca     360

agacataacc ctcgttacta tgctatggac tactggggcc aaggaaccac agtcaccgtc     420

tcctcaggta agaatggcct ctcaagctt                                       449


<210> 80
<211> 416
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic gene

<400> 80
gctagcacca ccatgttctc actggctctg ctcctcagtc tgctgctcct ctgtgtctct      60

gattctagag cagacatcca gatgacccag tctccaagct ccctgtccgc cagcgtggga     120

gatagagtca ccatcacatg catcaccagc actgatattg atgatgatat gaactggtac     180

cagcagaagc cagggaaagc tcctaagctc ctgatttcag aaggcaatac tctgcgccct     240

ggagtcccat cccgattctc cggcagtggc tatggaacag attttacctt tacaattagc     300

tccctgcagc cagaagatat tgcaacctac tactgtttgc aaagtgataa cctgccctac     360

accttcggag gggggaccaa agtcgaaatc aaacgtaagt agaatccaaa gaattc         416


<210> 81
<211> 416
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic gene

<400> 81
gctagcacca ccatgttctc actggctctg ctcctcagtc tgctgctcct ctgtgtctct      60

gattctagag cagacatcca gatgacccag tctccaagct ccctgtccgc cagcgtggga     120

gatagagtca ccatcacatg catcaccagc actgatattg atgatgatat gaactggtac     180

cagcagaagc cagggaaagc tcctaagctc ctgatttcag aaggcaatac tctgcgccct     240

ggagtcccat cccgattctc cggcagtggc tctggaacag attttacctt tacaattagc     300

tccctgcagc cagaagatat tgcaacctac tactgtttgc aaagtgataa cctgccctac     360

accttcggag gggggaccaa agtcgaaatc aaacgtaagt agaatccaaa gaattc         416


<210> 82
<211> 416
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic gene

<400> 82
gctagcacca ccatgttctc actggctctg ctcctcagtc tgctgctcct ctgtgtctct      60

gattctagag cagacaccca gatgacccag tctccaagct ccctgtccgc cagcgtggga     120

gatagagtca ccatcacatg catcaccagc actgatattg atgatgatat gaactggtac     180

cagcagaagc cagggaaagc tcctaagctc ctgatttcag aaggcaatac tctgcgccct     240

ggagtcccat cccgattctc cggcagtggc tatggaacag attttacctt tacaattagc     300

tccctgcagc cagaagatat tgcaacctac tactgtttgc aaagtgataa cctgccctac     360

accttcggag gggggaccaa agtcgaaatc aaacgtaagt agaatccaaa gaattc         416


<210> 83
<211> 1407
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic IGg

<400> 83
atggaatgga actgggtcgt tctcttcctc ctgtcattaa ctgcaggtgt ctattcccag      60

ggtcagatgc agcagtctgg agctgagctg gtgaagcctg gggcttcagt gaagctgtcc     120

tgcaagactt ctggcttcac cttcagcagt agctatataa gttggttgaa gcagaagcct     180

cgacagagtc ttgagtggat tgcatggatt tatgctggaa ctggtggtac tagctataat     240

cagaagttca caggcaaggc ccaactgact gtagacacat cctccagcac agcctacatg     300

caactcagca gcctgacatc tgaggactct gccatctatt actgtgcaag acataaccct     360

cgttactatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctcagcctcc     420

accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca     480

gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac     540

tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc     600

tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc     660

tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct     720

tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca     780

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc     840

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg     900

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg     960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac    1020

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc    1080

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc    1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg    1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac    1260

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag    1320

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag    1380

agcctctccc tgtctccggg taaatga                                        1407


<210> 84
<211> 468
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic IGg

<400> 84
Met Glu Trp Asn Trp Val Val Leu Phe Leu Leu Ser Leu Thr Ala Gly 
1               5                   10                  15      
Val Tyr Ser Gln Gly Gln Met Gln Gln Ser Gly Ala Glu Leu Val Lys 
            20                  25                  30          
Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe 
        35                  40                  45              
Ser Ser Ser Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu 
    50                  55                  60                  
Glu Trp Ile Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  
Gln Lys Phe Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      
Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         
Tyr Tyr Cys Ala Arg His Asn Pro Arg Tyr Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             
Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 
Ser Pro Gly Lys 
465             

<210> 85
<211> 705
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic IGg

<400> 85
atgttctcac tagctcttct cctcagtctt cttctcctct gtgtctctga ttctagggca      60

gaaacaactg tgacccagtc tccagcatcc ctgtccatgg ctataggaga aaaagtcacc     120

atcagatgca taaccagcac tgatattgat gatgatatga actggtacca gcagaagcca     180

ggggaacctc ctaagctcct tatttcagaa ggcaatactc ttcgtcctgg agtcccatcc     240

cgattctcca gcagtggcta tggtacagat tttgttttta caattgaaaa catgctctca     300

gaagatgttg cagattacta ctgtttgcaa agtgataact tgccgtacac gttcggaggg     360

gggaccaagc tggaaatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca     420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat     480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag     540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg     600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc     660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                     705


<210> 86
<211> 234
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic IGg

<400> 86
Met Phe Ser Leu Ala Leu Leu Leu Ser Leu Leu Leu Leu Cys Val Ser 
1               5                   10                  15      
Asp Ser Arg Ala Glu Thr Thr Val Thr Gln Ser Pro Ala Ser Leu Ser 
            20                  25                  30          
Met Ala Ile Gly Glu Lys Val Thr Ile Arg Cys Ile Thr Ser Thr Asp 
        35                  40                  45              
Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro 
    50                  55                  60                  
Lys Leu Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val Pro Ser 
65                  70                  75                  80  
Arg Phe Ser Ser Ser Gly Tyr Gly Thr Asp Phe Val Phe Thr Ile Glu 
                85                  90                  95      
Asn Met Leu Ser Glu Asp Val Ala Asp Tyr Tyr Cys Leu Gln Ser Asp 
            100                 105                 110         
Asn Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 

<210> 87
<211> 323
<212> PRT
<213> Homo sapiens

<220> 
<223> Human Trop-2

<400> 87
Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu 
1               5                   10                  15      
Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp 
            20                  25                  30          
Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly 
        35                  40                  45              
Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val 
    50                  55                  60                  
Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 
65                  70                  75                  80  
Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala 
                85                  90                  95      
Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly 
            100                 105                 110         
Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 
        115                 120                 125             
Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg 
    130                 135                 140                 
Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 
145                 150                 155                 160 
Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 
                165                 170                 175     
Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala 
            180                 185                 190         
Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 
        195                 200                 205             
Thr Ser Gln Lys Ala Ala Gly Asp Val Asp Ile Gly Asp Ala Ala Tyr 
    210                 215                 220                 
Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly 
225                 230                 235                 240 
Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr 
                245                 250                 255     
Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg 
            260                 265                 270         
Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu 
        275                 280                 285             
Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly 
    290                 295                 300                 
Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu 
305                 310                 315                 320 
Pro Ser Leu 
            

<210> 88
<211> 117
<212> PRT
<213> Homo sapiens

<220> 
<223> Framework of human VH M1775.1, wherein X is any of the 20 natural amino acids 

<400> 88
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr xxx xxx 
            20                  25                  30          
xxx xxx xxx Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx 
    50                  55                  60                  
xxx xxx Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg xxx xxx xxx xxx xxx xxx xxx xxx Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115                              

<210> 89
<211> 117
<212> PRT
<213> Homo sapiens

<220> 
<223> Framework of human VH L02325.1, wherein X is any of the 20 natural amino acids 

<400> 89
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr xxx xxx 
            20                  25                  30          
xxx xxx xxx Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx 
    50                  55                  60                  
xxx xxx Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg xxx xxx xxx xxx xxx xxx xxx xxx Trp Gly Gln Gly Thr Leu 
            100                 105                 110         
Val Thr Val Ser Ser 
        115                                     

<210> 90
<211> 119
<212> PRT
<213> Homo sapiens

<220> 
<223> Framework of human VH X65888.1, wherein X is any of the 20 natural amino acids 

<400> 90
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr xxx xxx 
            20                  25                  30          
xxx xxx xxx Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx 
    50                  55                  60                  
xxx xxx Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg xxx xxx xxx xxx xxx xxx xxx xxx xxx xxx Trp Gly Gln Gly 
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser 
        115                                  

<210> 91
<211> 111
<212> PRT
<213> Homo sapiens

<220> 
<223> Framework of human VL Z46622.1,wherein X is any of the 20 natural amino acids

<400> 91
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys xxx xxx xxx xxx xxx xxx xxx xxx xxx 
            20                  25                  30          
xxx xxx xxx xxx xxx xxx Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              
Lys Leu Leu Ile Tyr xxx xxx xxx xxx xxx xxx xxx Gly Val Pro Asp
    50                  55                  60                  
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser
65                  70                  75                  80  
Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys xxx xxx xxx xxx
                85                  90                  95      
xxx xxx xxx xxx xxx Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         

<210> 92
<211> 107
<212> PRT
<213> Homo sapiens

<220> 
<223> Framework of human VL AY043146.1, wherein X is any of the 20 natural amino acids

<400> 92
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys xxx xxx xxx xxx xxx xxx xxx xxx xxx 
            20                  25                  30          
xxx xxx Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr xxx xxx xxx xxx xxx xxx xxx Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys xxx xxx xxx xxx xxx xxx xxx xxx 
                85                  90                  95      
xxx Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210> 93
<211> 123
<212> PRT
<213> Homo sapiens

<220> 
<223> human VH M1775.1

<400> 93
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Met Ile Leu Arg Ile Gly His Gly Gln Pro Gln Gly Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210> 94
<211> 126
<212> PRT
<213> Homo sapiens

<220> 
<223> human VH L02325.1

<400> 94
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ala Pro His Gln Arg Thr Arg Ile Ala Ala Arg Pro Gly Glu 
            100                 105                 110         
Gly Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125  


<210> 95
<211> 124
<212> PRT
<213> Homo sapiens

<220> 
<223> human VH X65888.1

<400> 95
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              
Gly Trp Ile Asn Ala Gly Asn Gly Asn Thr Lys Tyr Ser Gln Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Leu Leu Cys Ser Gly Cys Asp Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120           

<210> 96
<211> 114
<212> PRT
<213> Homo sapiens

<220> 
<223> human VL Z46622.1

<400> 96
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      
Tyr Tyr Ser Thr Pro Ser Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu 
            100                 105                 110         
Ile Lys 
        

<210> 97
<211> 108
<212> PRT
<213> Homo sapiens

<220> 
<223> human VL AY043146.1

<400> 97
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ser 
                85                  90                  95      
Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                   