                         SEQUENCE LISTING

<110>  Q Therapeutics, Inc.
       Rao, Mahendra S
       Zeng, Xianmin
 
<120>  METHODS AND COMPOSITIONS FOR RAPID GENERATION OF SINGLE AND MULTIPLEXED 
       REPORTERS IN CELLS

<130>  QT0006WO

<150>  US 62/091,792
<151>  2014-12-15


<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  DNA
<213>  HUMAN

<400>  1
cttacccttc tcccatt                                                      17


<210>  2
<211>  1692
<212>  DNA
<213>  HUMAN

<400>  2
ctgaccccgg accaagtggt ggctatcgcc agccacgatg gcggcaagca agcgctcgaa       60

acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg      120

gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaacggtgca gcggctgttg      180

ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac      240

ggtggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac      300

catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg      360

ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gactccggac      420

caagtggtgg ctatcgccag ccacgatggc ggcaagcaag cgctcgaaac ggtgcagcgg      480

ctgttgccgg tgctgtgcca ggaccatggc ctgactccgg accaagtggt ggctatcgcc      540

agccacgatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc      600

caggaccatg gcctgactcc ggaccaagtg gtggctatcg ccagccacga tggcggcaag      660

caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc      720

ccggaccaag tggtggctat cgccagcaac ggtggcggca agcaagcgct cgaaacggtg      780

cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct      840

atcgccagca acggtggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg      900

ctgtgccagg accatggcct gactccggac caagtggtgg ctatcgccag ccacgatggc      960

ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc     1020

ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa     1080

acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg     1140

gtggctatcg ccagccacga tggcggcaag caagcgctcg aaacggtgca gcggctgttg     1200

ccggtgctgt gccaggacca tggcctgact ccggaccaag tggtggctat cgccagccac     1260

gatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac     1320

catggcctga ctccggacca agtggtggct atcgccagcc acgatggcgg caagcaagcg     1380

ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac     1440

caagtggtgg ctatcgccag caacattggc ggcaagcaag cgctcgaaac ggtgcagcgg     1500

ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc     1560

agcaacggtg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc     1620

caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag     1680

caagcgctcg aa                                                         1692


<210>  3
<211>  16
<212>  DNA
<213>  HUMAN

<400>  3
cccaaaatat atttat                                                       16


<210>  4
<211>  1590
<212>  DNA
<213>  HUMAN

<400>  4
ctgaccccgg accaagtggt ggctatcgcc agccacgatg gcggcaagca agcgctcgaa       60

acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgactcc ggaccaagtg      120

gtggctatcg ccagccacga tggcggcaag caagcgctcg aaacggtgca gcggctgttg      180

ccggtgctgt gccaggacca tggcctgact ccggaccaag tggtggctat cgccagccac      240

gatggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac      300

catggcctga ccccggacca agtggtggct atcgccagca acattggcgg caagcaagcg      360

ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac      420

caagtggtgg ctatcgccag caacattggc ggcaagcaag cgctcgaaac ggtgcagcgg      480

ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc      540

agcaacattg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc      600

caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacat tggcggcaag      660

caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc      720

ccggaccaag tggtggctat cgccagcaac ggtggcggca agcaagcgct cgaaacggtg      780

cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct      840

atcgccagca acattggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg      900

ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacggtggc      960

ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc     1020

ctgaccccgg accaagtggt ggctatcgcc agcaacattg gcggcaagca agcgctcgaa     1080

acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg     1140

gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaacggtgca gcggctgttg     1200

ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac     1260

ggtggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac     1320

catggcctga ccccggacca agtggtggct atcgccagca acggtggcgg caagcaagcg     1380

ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac     1440

caagtggtgg ctatcgccag caacattggc ggcaagcaag cgctcgaaac ggtgcagcgg     1500

ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc     1560

agcaacggtg gcggcaagca agcgctcgaa                                      1590


<210>  5
<211>  2889
<212>  DNA
<213>  HUMAN

<400>  5
gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc       60

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      120

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      180

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      240

tcgggagcgc gagcacttga ggccttgctg actgtggcgg gtgagcttag ggggcctccg      300

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      360

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccctgaacct gaccccggac      420

caagtggtgg ctatcgccag ccacgatggc ggcaagcaag cgctcgaaac ggtgcagcgg      480

ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc      540

agcaacggtg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc      600

caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag      660

caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc      720

ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaacggtg      780

cagcggctgt tgccggtgct gtgccaggac catggcctga ctccggacca agtggtggct      840

atcgccagcc acgatggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg      900

ctgtgccagg accatggcct gactccggac caagtggtgg ctatcgccag ccacgatggc      960

ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc     1020

ctgactccgg accaagtggt ggctatcgcc agccacgatg gcggcaagca agcgctcgaa     1080

acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg     1140

gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaacggtgca gcggctgttg     1200

ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac     1260

ggtggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac     1320

catggcctga ctccggacca agtggtggct atcgccagcc acgatggcgg caagcaagcg     1380

ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac     1440

caagtggtgg ctatcgccag caacggtggc ggcaagcaag cgctcgaaac ggtgcagcgg     1500

ctgttgccgg tgctgtgcca ggaccatggc ctgactccgg accaagtggt ggctatcgcc     1560

agccacgatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc     1620

caggaccatg gcctgactcc ggaccaagtg gtggctatcg ccagccacga tggcggcaag     1680

caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgact     1740

ccggaccaag tggtggctat cgccagccac gatggcggca agcaagcgct cgaaacggtg     1800

cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct     1860

atcgccagca acattggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg     1920

ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacggtggc     1980

ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc     2040

ctgaccccgg accaagtggt ggctatcgcc agcaacggtg gcggcaagca agcgctcgaa     2100

agcattgtgg cccagctgag ccggcctgat ccggcgttgg ccgcgttgac caacgaccat     2160

ctggtggcgt tggcatgtct tggtggacgt cccgcgctcg atgcagtcaa aaagggtctg     2220

cctcatgctc ccgcattgat caaaagaacc aaccggcgga ttcccgagag aacttcccat     2280

cgagtcgcgg gatcccaact agtcaaaagt gaactggagg agaagaaatc tgaacttcgt     2340

cataaattga aatatgtgcc tcatgaatat attgaattaa ttgaaattgc cagaaattcc     2400

actcaggata gaattcttga aatgaaggta atggaatttt ttatgaaagt ttatggatat     2460

agaggtaaac atttgggtgg atcaaggaaa ccggacggag caatttatac tgtcggatct     2520

cctattgatt acggtgtgat cgtggatact aaagcttata gcggaggtta taatctgcca     2580

attggccaag cagatgaaat gcaacgatat gtcgaagaaa atcaaacacg aaacaaacat     2640

atcaacccta atgaatggtg gaaagtctat ccatcttctg taacggaatt taagttttta     2700

tttgtgagtg gtcactttaa aggaaactac aaagctcagc ttacacgatt aaatcatatc     2760

actaattgta atggagctgt tcttagtgta gaagagcttt taattggtgg agaaatgatt     2820

aaagccggca cattaacctt agaggaagtc agacggaaat ttaataacgg cgagataaac     2880

tttagatct                                                             2889


<210>  6
<211>  2787
<212>  DNA
<213>  HUMAN

<400>  6
gtggacttga ggacactcgg ttattcgcaa cagcaacagg agaaaatcaa gcctaaggtc       60

aggagcaccg tcgcgcaaca ccacgaggcg cttgtggggc atggcttcac tcatgcgcat      120

attgtcgcgc tttcacagca ccctgcggcg cttgggacgg tggctgtcaa ataccaagat      180

atgattgcgg ccctgcccga agccacgcac gaggcaattg taggggtcgg taaacagtgg      240

tcgggagcgc gagcacttga ggccttgctg actgtggcgg gtgagcttag ggggcctccg      300

ctccagctcg acaccgggca gctgctgaag atcgcgaaga gagggggagt aacagcggta      360

gaggcagtgc acgcctggcg caatgcgctc accggggccc ccctgaacct gaccccggac      420

caagtggtgg ctatcgccag ccacgatggc ggcaagcaag cgctcgaaac ggtgcagcgg      480

ctgttgccgg tgctgtgcca ggaccatggc ctgactccgg accaagtggt ggctatcgcc      540

agccacgatg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc      600

caggaccatg gcctgactcc ggaccaagtg gtggctatcg ccagccacga tggcggcaag      660

caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc      720

ccggaccaag tggtggctat cgccagcaac attggcggca agcaagcgct cgaaacggtg      780

cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct      840

atcgccagca acattggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg      900

ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacattggc      960

ggcaagcaag cgctcgaaac ggtgcagcgg ctgttgccgg tgctgtgcca ggaccatggc     1020

ctgaccccgg accaagtggt ggctatcgcc agcaacattg gcggcaagca agcgctcgaa     1080

acggtgcagc ggctgttgcc ggtgctgtgc caggaccatg gcctgacccc ggaccaagtg     1140

gtggctatcg ccagcaacgg tggcggcaag caagcgctcg aaacggtgca gcggctgttg     1200

ccggtgctgt gccaggacca tggcctgacc ccggaccaag tggtggctat cgccagcaac     1260

attggcggca agcaagcgct cgaaacggtg cagcggctgt tgccggtgct gtgccaggac     1320

catggcctga ccccggacca agtggtggct atcgccagca acggtggcgg caagcaagcg     1380

ctcgaaacgg tgcagcggct gttgccggtg ctgtgccagg accatggcct gaccccggac     1440

caagtggtgg ctatcgccag caacattggc ggcaagcaag cgctcgaaac ggtgcagcgg     1500

ctgttgccgg tgctgtgcca ggaccatggc ctgaccccgg accaagtggt ggctatcgcc     1560

agcaacggtg gcggcaagca agcgctcgaa acggtgcagc ggctgttgcc ggtgctgtgc     1620

caggaccatg gcctgacccc ggaccaagtg gtggctatcg ccagcaacgg tggcggcaag     1680

caagcgctcg aaacggtgca gcggctgttg ccggtgctgt gccaggacca tggcctgacc     1740

ccggaccaag tggtggctat cgccagcaac ggtggcggca agcaagcgct cgaaacggtg     1800

cagcggctgt tgccggtgct gtgccaggac catggcctga ccccggacca agtggtggct     1860

atcgccagca acattggcgg caagcaagcg ctcgaaacgg tgcagcggct gttgccggtg     1920

ctgtgccagg accatggcct gaccccggac caagtggtgg ctatcgccag caacggtggc     1980

ggcaagcaag cgctcgaaag cattgtggcc cagctgagcc ggcctgatcc ggcgttggcc     2040

gcgttgacca acgaccatct ggtggcgttg gcatgtcttg gtggacgtcc cgcgctcgat     2100

gcagtcaaaa agggtctgcc tcatgctccc gcattgatca aaagaaccaa ccggcggatt     2160

cccgagagaa cttcccatcg agtcgcggga tcccaactag tcaaaagtga actggaggag     2220

aagaaatctg aacttcgtca taaattgaaa tatgtgcctc atgaatatat tgaattaatt     2280

gaaattgcca gaaattccac tcaggataga attcttgaaa tgaaggtaat ggaatttttt     2340

atgaaagttt atggatatag aggtaaacat ttgggtggat caaggaaacc ggacggagca     2400

atttatactg tcggatctcc tattgattac ggtgtgatcg tggatactaa agcttatagc     2460

ggaggttata atctgccaat tggccaagca gatgaaatgc aacgatatgt cgaagaaaat     2520

caaacacgaa acaaacatat caaccctaat gaatggtgga aagtctatcc atcttctgta     2580

acggaattta agtttttatt tgtgagtggt cactttaaag gaaactacaa agctcagctt     2640

acacgattaa atcatatcac taattgtaat ggagctgttc ttagtgtaga agagctttta     2700

attggtggag aaatgattaa agccggcaca ttaaccttag aggaagtcag acggaaattt     2760

aataacggcg agataaactt tagatct                                         2787


<210>  7
<211>  564
<212>  PRT
<213>  HUMAN

<400>  7

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            20                  25                  30          


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
225                 230                 235                 240 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            260                 265                 270         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    290                 295                 300                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
            500                 505                 510         


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
    530                 535                 540                 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu 
                


<210>  8
<211>  963
<212>  PRT
<213>  HUMAN

<400>  8

Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
1               5                   10                  15      


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            20                  25                  30          


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        35                  40                  45              


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
    50                  55                  60                  


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
65                  70                  75                  80  


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
                85                  90                  95      


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
            100                 105                 110         


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
        115                 120                 125             


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
225                 230                 235                 240 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            260                 265                 270         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    290                 295                 300                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His 
            340                 345                 350         


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
            500                 505                 510         


Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
    530                 535                 540                 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
                565                 570                 575     


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
    610                 615                 620                 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
625                 630                 635                 640 


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
                645                 650                 655     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
            660                 665                 670         


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
        675                 680                 685             


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala 
    690                 695                 700                 


Gln Leu Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His 
705                 710                 715                 720 


Leu Val Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val 
                725                 730                 735     


Lys Lys Gly Leu Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg 
            740                 745                 750         


Arg Ile Pro Glu Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val 
        755                 760                 765             


Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys 
    770                 775                 780                 


Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser 
785                 790                 795                 800 


Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys 
                805                 810                 815     


Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp 
            820                 825                 830         


Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val 
        835                 840                 845             


Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala 
    850                 855                 860                 


Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His 
865                 870                 875                 880 


Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu 
                885                 890                 895     


Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala 
            900                 905                 910         


Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu 
        915                 920                 925             


Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr 
    930                 935                 940                 


Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn 
945                 950                 955                 960 


Phe Arg Ser 
            


<210>  9
<211>  3006
<212>  DNA
<213>  HUMAN

<400>  9
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca tccacggggt acctatggtg      120

gacttgagga cactcggtta ttcgcaacag caacaggaga aaatcaagcc taaggtcagg      180

agcaccgtcg cgcaacacca cgaggcgctt gtggggcatg gcttcactca tgcgcatatt      240

gtcgcgcttt cacagcaccc tgcggcgctt gggacggtgg ctgtcaaata ccaagatatg      300

attgcggccc tgcccgaagc cacgcacgag gcaattgtag gggtcggtaa acagtggtcg      360

ggagcgcgag cacttgaggc cttgctgact gtggcgggtg agcttagggg gcctccgctc      420

cagctcgaca ccgggcagct gctgaagatc gcgaagagag ggggagtaac agcggtagag      480

gcagtgcacg cctggcgcaa tgcgctcacc ggggcccccc tgaacctgac cccggaccaa      540

gtggtggcta tcgccagcca cgatggcggc aagcaagcgc tcgaaacggt gcagcggctg      600

ttgccggtgc tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc      660

aacggtggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag      720

gaccatggcc tgaccccgga ccaagtggtg gctatcgcca gcaacggtgg cggcaagcaa      780

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg      840

gaccaagtgg tggctatcgc cagcaacatt ggcggcaagc aagcgctcga aacggtgcag      900

cggctgttgc cggtgctgtg ccaggaccat ggcctgactc cggaccaagt ggtggctatc      960

gccagccacg atggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg     1020

tgccaggacc atggcctgac tccggaccaa gtggtggcta tcgccagcca cgatggcggc     1080

aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg     1140

actccggacc aagtggtggc tatcgccagc cacgatggcg gcaagcaagc gctcgaaacg     1200

gtgcagcggc tgttgccggt gctgtgccag gaccatggcc tgaccccgga ccaagtggtg     1260

gctatcgcca gcaacggtgg cggcaagcaa gcgctcgaaa cggtgcagcg gctgttgccg     1320

gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg tggctatcgc cagcaacggt     1380

ggcggcaagc aagcgctcga aacggtgcag cggctgttgc cggtgctgtg ccaggaccat     1440

ggcctgactc cggaccaagt ggtggctatc gccagccacg atggcggcaa gcaagcgctc     1500

gaaacggtgc agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa     1560

gtggtggcta tcgccagcaa cggtggcggc aagcaagcgc tcgaaacggt gcagcggctg     1620

ttgccggtgc tgtgccagga ccatggcctg actccggacc aagtggtggc tatcgccagc     1680

cacgatggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag     1740

gaccatggcc tgactccgga ccaagtggtg gctatcgcca gccacgatgg cggcaagcaa     1800

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgactccg     1860

gaccaagtgg tggctatcgc cagccacgat ggcggcaagc aagcgctcga aacggtgcag     1920

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc     1980

gccagcaaca ttggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg     2040

tgccaggacc atggcctgac cccggaccaa gtggtggcta tcgccagcaa cggtggcggc     2100

aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg     2160

accccggacc aagtggtggc tatcgccagc aacggtggcg gcaagcaagc gctcgaaagc     2220

attgtggccc agctgagccg gcctgatccg gcgttggccg cgttgaccaa cgaccatctg     2280

gtggcgttgg catgtcttgg tggacgtccc gcgctcgatg cagtcaaaaa gggtctgcct     2340

catgctcccg cattgatcaa aagaaccaac cggcggattc ccgagagaac ttcccatcga     2400

gtcgcgggat cccaactagt caaaagtgaa ctggaggaga agaaatctga acttcgtcat     2460

aaattgaaat atgtgcctca tgaatatatt gaattaattg aaattgccag aaattccact     2520

caggatagaa ttcttgaaat gaaggtaatg gaatttttta tgaaagttta tggatataga     2580

ggtaaacatt tgggtggatc aaggaaaccg gacggagcaa tttatactgt cggatctcct     2640

attgattacg gtgtgatcgt ggatactaaa gcttatagcg gaggttataa tctgccaatt     2700

ggccaagcag atgaaatgca acgatatgtc gaagaaaatc aaacacgaaa caaacatatc     2760

aaccctaatg aatggtggaa agtctatcca tcttctgtaa cggaatttaa gtttttattt     2820

gtgagtggtc actttaaagg aaactacaaa gctcagctta cacgattaaa tcatatcact     2880

aattgtaatg gagctgttct tagtgtagaa gagcttttaa ttggtggaga aatgattaaa     2940

gccggcacat taaccttaga ggaagtcaga cggaaattta ataacggcga gataaacttt     3000

agatct                                                                3006


<210>  10
<211>  530
<212>  PRT
<213>  HUMAN

<400>  10

Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
            20                  25                  30          


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His Asp Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser His 
65                  70                  75                  80  


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
225                 230                 235                 240 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            260                 265                 270         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    290                 295                 300                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
            500                 505                 510         


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  11
<211>  929
<212>  PRT
<213>  HUMAN

<400>  11

Val Asp Leu Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile 
1               5                   10                  15      


Lys Pro Lys Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val 
            20                  25                  30          


Gly His Gly Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro 
        35                  40                  45              


Ala Ala Leu Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala 
    50                  55                  60                  


Leu Pro Glu Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp 
65                  70                  75                  80  


Ser Gly Ala Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu 
                85                  90                  95      


Arg Gly Pro Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala 
            100                 105                 110         


Lys Arg Gly Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn 
        115                 120                 125             


Ala Leu Thr Gly Ala Pro Leu Asn Leu Thr Pro Asp Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
225                 230                 235                 240 


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
            260                 265                 270         


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
    290                 295                 300                 


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Ile Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr Pro Asp 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly Leu Thr 
            500                 505                 510         


Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala 
        515                 520                 525             


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp His Gly 
    530                 535                 540                 


Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
545                 550                 555                 560 


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Asp 
                565                 570                 575     


His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
            580                 585                 590         


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
        595                 600                 605             


Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala Ser Asn 
    610                 615                 620                 


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
625                 630                 635                 640 


Leu Cys Gln Asp His Gly Leu Thr Pro Asp Gln Val Val Ala Ile Ala 
                645                 650                 655     


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Ser Ile Val Ala Gln Leu 
            660                 665                 670         


Ser Arg Pro Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val 
        675                 680                 685             


Ala Leu Ala Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys 
    690                 695                 700                 


Gly Leu Pro His Ala Pro Ala Leu Ile Lys Arg Thr Asn Arg Arg Ile 
705                 710                 715                 720 


Pro Glu Arg Thr Ser His Arg Val Ala Gly Ser Gln Leu Val Lys Ser 
                725                 730                 735     


Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val 
            740                 745                 750         


Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln 
        755                 760                 765             


Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr 
    770                 775                 780                 


Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala 
785                 790                 795                 800 


Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr 
                805                 810                 815     


Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu 
            820                 825                 830         


Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn 
        835                 840                 845             


Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys 
    850                 855                 860                 


Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu 
865                 870                 875                 880 


Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val 
                885                 890                 895     


Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr 
            900                 905                 910         


Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Arg 
        915                 920                 925             


Ser 
    


<210>  12
<211>  2904
<212>  DNA
<213>  HUMAN

<400>  12
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaaga tggcccccaa gaagaagagg aaggtgggca tccacggggt acctatggtg      120

gacttgagga cactcggtta ttcgcaacag caacaggaga aaatcaagcc taaggtcagg      180

agcaccgtcg cgcaacacca cgaggcgctt gtggggcatg gcttcactca tgcgcatatt      240

gtcgcgcttt cacagcaccc tgcggcgctt gggacggtgg ctgtcaaata ccaagatatg      300

attgcggccc tgcccgaagc cacgcacgag gcaattgtag gggtcggtaa acagtggtcg      360

ggagcgcgag cacttgaggc cttgctgact gtggcgggtg agcttagggg gcctccgctc      420

cagctcgaca ccgggcagct gctgaagatc gcgaagagag ggggagtaac agcggtagag      480

gcagtgcacg cctggcgcaa tgcgctcacc ggggcccccc tgaacctgac cccggaccaa      540

gtggtggcta tcgccagcca cgatggcggc aagcaagcgc tcgaaacggt gcagcggctg      600

ttgccggtgc tgtgccagga ccatggcctg actccggacc aagtggtggc tatcgccagc      660

cacgatggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag      720

gaccatggcc tgactccgga ccaagtggtg gctatcgcca gccacgatgg cggcaagcaa      780

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg      840

gaccaagtgg tggctatcgc cagcaacatt ggcggcaagc aagcgctcga aacggtgcag      900

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc      960

gccagcaaca ttggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg     1020

tgccaggacc atggcctgac cccggaccaa gtggtggcta tcgccagcaa cattggcggc     1080

aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg     1140

accccggacc aagtggtggc tatcgccagc aacattggcg gcaagcaagc gctcgaaacg     1200

gtgcagcggc tgttgccggt gctgtgccag gaccatggcc tgaccccgga ccaagtggtg     1260

gctatcgcca gcaacggtgg cggcaagcaa gcgctcgaaa cggtgcagcg gctgttgccg     1320

gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg tggctatcgc cagcaacatt     1380

ggcggcaagc aagcgctcga aacggtgcag cggctgttgc cggtgctgtg ccaggaccat     1440

ggcctgaccc cggaccaagt ggtggctatc gccagcaacg gtggcggcaa gcaagcgctc     1500

gaaacggtgc agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa     1560

gtggtggcta tcgccagcaa cattggcggc aagcaagcgc tcgaaacggt gcagcggctg     1620

ttgccggtgc tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc     1680

aacggtggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag     1740

gaccatggcc tgaccccgga ccaagtggtg gctatcgcca gcaacggtgg cggcaagcaa     1800

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg     1860

gaccaagtgg tggctatcgc cagcaacggt ggcggcaagc aagcgctcga aacggtgcag     1920

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc     1980

gccagcaaca ttggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg     2040

tgccaggacc atggcctgac cccggaccaa gtggtggcta tcgccagcaa cggtggcggc     2100

aagcaagcgc tcgaaagcat tgtggcccag ctgagccggc ctgatccggc gttggccgcg     2160

ttgaccaacg accatctggt ggcgttggca tgtcttggtg gacgtcccgc gctcgatgca     2220

gtcaaaaagg gtctgcctca tgctcccgca ttgatcaaaa gaaccaaccg gcggattccc     2280

gagagaactt cccatcgagt cgcgggatcc caactagtca aaagtgaact ggaggagaag     2340

aaatctgaac ttcgtcataa attgaaatat gtgcctcatg aatatattga attaattgaa     2400

attgccagaa attccactca ggatagaatt cttgaaatga aggtaatgga attttttatg     2460

aaagtttatg gatatagagg taaacatttg ggtggatcaa ggaaaccgga cggagcaatt     2520

tatactgtcg gatctcctat tgattacggt gtgatcgtgg atactaaagc ttatagcgga     2580

ggttataatc tgccaattgg ccaagcagat gaaatgcaac gatatgtcga agaaaatcaa     2640

acacgaaaca aacatatcaa ccctaatgaa tggtggaaag tctatccatc ttctgtaacg     2700

gaatttaagt ttttatttgt gagtggtcac tttaaaggaa actacaaagc tcagcttaca     2760

cgattaaatc atatcactaa ttgtaatgga gctgttctta gtgtagaaga gcttttaatt     2820

ggtggagaaa tgattaaagc cggcacatta accttagagg aagtcagacg gaaatttaat     2880

aacggcgaga taaactttag atct                                            2904


<210>  13
<211>  199
<212>  PRT
<213>  HUMAN

<400>  13

Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg 
1               5                   10                  15      


His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile 
            20                  25                  30          


Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu 
        35                  40                  45              


Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser 
    50                  55                  60                  


Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr 
65                  70                  75                  80  


Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro 
                85                  90                  95      


Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr 
            100                 105                 110         


Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser 
        115                 120                 125             


Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly 
    130                 135                 140                 


Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn 
145                 150                 155                 160 


Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile 
                165                 170                 175     


Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn 
            180                 185                 190         


Gly Glu Ile Asn Phe Arg Ser 
        195                 


<210>  14
<211>  597
<212>  DNA
<213>  HUMAN

<400>  14
tcccaactag tcaaaagtga actggaggag aagaaatctg aacttcgtca taaattgaaa       60

tatgtgcctc atgaatatat tgaattaatt gaaattgcca gaaattccac tcaggataga      120

attcttgaaa tgaaggtaat ggaatttttt atgaaagttt atggatatag aggtaaacat      180

ttgggtggat caaggaaacc ggacggagca atttatactg tcggatctcc tattgattac      240

ggtgtgatcg tggatactaa agcttatagc ggaggttata atctgccaat tggccaagca      300

gatgaaatgc aacgatatgt cgaagaaaat caaacacgaa acaaacatat caaccctaat      360

gaatggtgga aagtctatcc atcttctgta acggaattta agtttttatt tgtgagtggt      420

cactttaaag gaaactacaa agctcagctt acacgattaa atcatatcac taattgtaat      480

ggagctgttc ttagtgtaga agagctttta attggtggag aaatgattaa agccggcaca      540

ttaaccttag aggaagtcag acggaaattt aataacggcg agataaactt tagatct         597


<210>  15
<211>  21
<212>  DNA
<213>  HUMAN

<400>  15
cccaagaaga agaggaaggt g                                                 21


<210>  16
<211>  7
<212>  PRT
<213>  HUMAN

<400>  16

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  17
<211>  69
<212>  DNA
<213>  HUMAN

<400>  17
atggactaca aagaccatga cggtgattat aaagatcatg acatcgatta caaggatgac       60

gatgacaag                                                               69


<210>  18
<211>  23
<212>  PRT
<213>  HUMAN

<400>  18

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys 
            20              


<210>  19
<211>  49
<212>  DNA
<213>  HUMAN

<400>  19
cttacccttc tcccatttcc tcatccttcc aacataaata tattttggg                   49


<210>  20
<211>  20
<212>  DNA
<213>  HUMAN

<400>  20
ctgccgtctc tctcctgagt                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  HUMAN

<400>  21
gtgggcttgt actcggtcat                                                   20


