                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
 
<120>  PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ADAM17 SUBSTRATE 
       DEPENDANT CANCERS

<130>  368307D34536

<150>  EP14307190.0
<151>  2014-12-24

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (X1)


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  X is N, D, Q, S, E, R, K, H, W, Y or T

<400>  1

Gly Phe Ser Leu Xaa Thr Ser Gly Met Gly 
1               5                   10  


<210>  2
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H2

<400>  2

Ile Tyr Trp Asp Asp Asp Lys 
1               5           


<210>  3
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H3

<400>  3

Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
1               5                   10                  15  


<210>  4
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-L1

<400>  4

Gln Asp Ile Ser Ser Tyr 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-L2

<400>  5

Tyr Thr Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-L3

<400>  6

Gln Gln Gly Lys Thr Leu Pro Leu Thr 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (N)

<400>  7

Gly Phe Ser Leu Asn Thr Ser Gly Met Gly 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (D)

<400>  8

Gly Phe Ser Leu Asp Thr Ser Gly Met Gly 
1               5                   10  


<210>  9
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (X1)


<220>
<221>  VARIANT
<222>  (30)..(30)
<223>  X is N, D, Q, S, E, R, K, H, W, Y or T

<400>  9

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Xaa Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser 
        115                 120             


<210>  10
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody light chain variable domain

<400>  10

Asp Val Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Lys Tyr Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Ala Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  11
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (N)

<400>  11

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser 
        115                 120             


<210>  12
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (D)

<400>  12

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser 
        115                 120             


<210>  13
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (X2)


<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  nnn is AAC, AAT, GAC, GAT, CAG, CAA, TCG, TCT, TCA, TCC, AGT, 
       AGC, GAA, GAG, CGA, CGT, CGC, CGG, AGA, AGG, AAA, AAG, CAT, CAC, 
       TGG, TAT, TAC, ACT, ACC, ACG or ACA

<400>  13
gggttttcac tgnnnacttc tggtatgggt                                        30


<210>  14
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H2

<400>  14
atttactggg atgacgacaa g                                                 21


<210>  15
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H3

<400>  15
gctcgaagat ctcactttgg taactattac tatgctatgg actac                       45


<210>  16
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-L1

<400>  16
caggacatta gtagttat                                                     18


<210>  17
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-L2

<400>  17
tacacatca                                                                9


<210>  18
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-L3

<400>  18
caacagggta aaacacttcc gctcacg                                           27


<210>  19
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (aac)

<400>  19
gggttttcac tgaacacttc tggtatgggt                                        30


<210>  20
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (aat)

<400>  20
gggttttcac tgaatacttc tggtatgggt                                        30


<210>  21
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (gac)

<400>  21
gggttttcac tggacacttc tggtatgggt                                        30


<210>  22
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody CDR-H1 (gat)

<400>  22
gggttttcac tggatacttc tggtatgggt                                        30


<210>  23
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (X2)


<220>
<221>  misc_feature
<222>  (88)..(90)
<223>  nnn is AAC, AAT, GAC, GAT, CAG, CAA, TCG, TCT, TCA, TCC, AGT, 
       AGC, GAA, GAG, CGA, CGT, CGC, CGG, AGA, AGG, AAA, AAG, CAT, CAC, 
       TGG, TAT, TAC, ACT, ACC, ACG or ACA

<400>  23
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgnnn acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga cgacaagcgc      180

tataatccat ccctgaagag ccggctcaca atctccaagg atacctccag caaccaggtt      240

ttcctcaaga tcaccagttt ggacactgca gatactgcca catactactg tgctcgaaga      300

tctcactttg gtaactatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtcacctca                                                              369


<210>  24
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (aac)

<400>  24
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgaac acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga cgacaagcgc      180

tataatccat ccctgaagag ccggctcaca atctccaagg atacctccag caaccaggtt      240

ttcctcaaga tcaccagttt ggacactgca gatactgcca catactactg tgctcgaaga      300

tctcactttg gtaactatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtcacctca                                                              369


<210>  25
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (gat)

<400>  25
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactggat acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga cgacaagcgc      180

tataatccat ccctgaagag ccggctcaca atctccaagg atacctccag caaccaggtt      240

ttcctcaaga tcaccagttt ggacactgca gatactgcca catactactg tgctcgaaga      300

tctcactttg gtaactatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtcacctca                                                              369


<210>  26
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody light chain variable domain

<400>  26
gatgtccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gggcaagtca ggacattagt agttatttaa attggtatca gcagaaacca      120

gatggaactt ttaaactcct gatcttctac acatcaagat tacagtcagg agtcccatca      180

aaatacagtg gcagtgggtc tggaacagat tattctctca ccattagtaa cctggagcaa      240

gaagatattg ccgcttactt ttgccaacag ggtaaaacac ttccgctcac gttcggggct      300

gggaccaagc tggaactgaa a                                                321


<210>  27
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (aat)

<400>  27
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgaat acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga cgacaagcgc      180

tataatccat ccctgaagag ccggctcaca atctccaagg atacctccag caaccaggtt      240

ttcctcaaga tcaccagttt ggacactgca gatactgcca catactactg tgctcgaaga      300

tctcactttg gtaactatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtcacctca                                                              369


<210>  28
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain variable domain (gac)

<400>  28
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactggac acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga cgacaagcgc      180

tataatccat ccctgaagag ccggctcaca atctccaagg atacctccag caaccaggtt      240

ttcctcaaga tcaccagttt ggacactgca gatactgcca catactactg tgctcgaaga      300

tctcactttg gtaactatta ctatgctatg gactactggg gtcaaggaac ctcagtcacc      360

gtcacctca                                                              369


<210>  29
<211>  824
<212>  PRT
<213>  artificial

<220>
<223>  ADAM17

<400>  29

Met Arg Gln Ser Leu Leu Phe Leu Thr Ser Val Val Pro Phe Val Leu 
1               5                   10                  15      


Ala Pro Arg Pro Pro Asp Asp Pro Gly Phe Gly Pro His Gln Arg Leu 
            20                  25                  30          


Glu Lys Leu Asp Ser Leu Leu Ser Asp Tyr Asp Ile Leu Ser Leu Ser 
        35                  40                  45              


Asn Ile Gln Gln His Ser Val Arg Lys Arg Asp Leu Gln Thr Ser Thr 
    50                  55                  60                  


His Val Glu Thr Leu Leu Thr Phe Ser Ala Leu Lys Arg His Phe Lys 
65                  70                  75                  80  


Leu Tyr Leu Thr Ser Ser Thr Glu Arg Phe Ser Gln Asn Phe Lys Val 
                85                  90                  95      


Val Val Val Asp Gly Lys Asn Glu Ser Glu Tyr Thr Val Lys Trp Gln 
            100                 105                 110         


Asp Phe Phe Thr Gly His Val Val Gly Glu Pro Asp Ser Arg Val Leu 
        115                 120                 125             


Ala His Ile Arg Asp Asp Asp Val Ile Ile Arg Ile Asn Thr Asp Gly 
    130                 135                 140                 


Ala Glu Tyr Asn Ile Glu Pro Leu Trp Arg Phe Val Asn Asp Thr Lys 
145                 150                 155                 160 


Asp Lys Arg Met Leu Val Tyr Lys Ser Glu Asp Ile Lys Asn Val Ser 
                165                 170                 175     


Arg Leu Gln Ser Pro Lys Val Cys Gly Tyr Leu Lys Val Asp Asn Glu 
            180                 185                 190         


Glu Leu Leu Pro Lys Gly Leu Val Asp Arg Glu Pro Pro Glu Glu Leu 
        195                 200                 205             


Val His Arg Val Lys Arg Arg Ala Asp Pro Asp Pro Met Lys Asn Thr 
    210                 215                 220                 


Cys Lys Leu Leu Val Val Ala Asp His Arg Phe Tyr Arg Tyr Met Gly 
225                 230                 235                 240 


Arg Gly Glu Glu Ser Thr Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp 
                245                 250                 255     


Arg Val Asp Asp Ile Tyr Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe 
            260                 265                 270         


Lys Gly Tyr Gly Ile Gln Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro 
        275                 280                 285             


Gln Glu Val Lys Pro Gly Glu Lys His Tyr Asn Met Ala Lys Ser Tyr 
    290                 295                 300                 


Pro Asn Glu Glu Lys Asp Ala Trp Asp Val Lys Met Leu Leu Glu Gln 
305                 310                 315                 320 


Phe Ser Phe Asp Ile Ala Glu Glu Ala Ser Lys Val Cys Leu Ala His 
                325                 330                 335     


Leu Phe Thr Tyr Gln Asp Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr 
            340                 345                 350         


Val Gly Ser Pro Arg Ala Asn Ser His Gly Gly Val Cys Pro Lys Ala 
        355                 360                 365             


Tyr Tyr Ser Pro Val Gly Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu 
    370                 375                 380                 


Thr Ser Thr Lys Asn Tyr Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp 
385                 390                 395                 400 


Leu Val Thr Thr His Glu Leu Gly His Asn Phe Gly Ala Glu His Asp 
                405                 410                 415     


Pro Asp Gly Leu Ala Glu Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys 
            420                 425                 430         


Tyr Val Met Tyr Pro Ile Ala Val Ser Gly Asp His Glu Asn Asn Lys 
        435                 440                 445             


Met Phe Ser Asn Cys Ser Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser 
    450                 455                 460                 


Lys Ala Gln Glu Cys Phe Gln Glu Arg Ser Asn Lys Val Cys Gly Asn 
465                 470                 475                 480 


Ser Arg Val Asp Glu Gly Glu Glu Cys Asp Pro Gly Ile Met Tyr Leu 
                485                 490                 495     


Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys Thr Leu Lys Glu Gly Val 
            500                 505                 510         


Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys Lys Asn Cys Gln Phe Glu 
        515                 520                 525             


Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile Asn Ala Thr Cys Lys Gly 
    530                 535                 540                 


Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu Cys Pro Pro Pro Gly Asn 
545                 550                 555                 560 


Ala Glu Asp Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly 
                565                 570                 575     


Lys Cys Ile Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala 
            580                 585                 590         


Cys Asn Glu Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser 
        595                 600                 605             


Gly Arg Cys Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu 
    610                 615                 620                 


Arg Lys Gly Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys 
625                 630                 635                 640 


Cys Glu Lys Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile 
                645                 650                 655     


Asp Gln Leu Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn Ile 
            660                 665                 670         


Val Gly Ser Val Leu Val Phe Ser Leu Ile Phe Trp Ile Pro Phe Ser 
        675                 680                 685             


Ile Leu Val His Cys Val Asp Lys Lys Leu Asp Lys Gln Tyr Glu Ser 
    690                 695                 700                 


Leu Ser Leu Phe His Pro Ser Asn Val Glu Met Leu Ser Ser Met Asp 
705                 710                 715                 720 


Ser Ala Ser Val Arg Ile Ile Lys Pro Phe Pro Ala Pro Gln Thr Pro 
                725                 730                 735     


Gly Arg Leu Gln Pro Ala Pro Val Ile Pro Ser Ala Pro Ala Ala Pro 
            740                 745                 750         


Lys Leu Asp His Gln Arg Met Asp Thr Ile Gln Glu Asp Pro Ser Thr 
        755                 760                 765             


Asp Ser His Met Asp Glu Asp Gly Phe Glu Lys Asp Pro Phe Pro Asn 
    770                 775                 780                 


Ser Ser Thr Ala Ala Lys Ser Phe Glu Asp Leu Thr Asp His Pro Val 
785                 790                 795                 800 


Thr Arg Ser Glu Lys Ala Ala Ser Phe Lys Leu Gln Arg Gln Asn Arg 
                805                 810                 815     


Val Asp Ser Lys Glu Thr Glu Cys 
            820                 


<210>  30
<211>  260
<212>  PRT
<213>  artificial

<220>
<223>  Metalloprotease domain of ADAM17

<400>  30

Arg Ala Asp Pro Asp Pro Met Lys Asn Thr Cys Lys Leu Leu Val Val 
1               5                   10                  15      


Ala Asp His Arg Phe Tyr Arg Tyr Met Gly Arg Gly Glu Glu Ser Thr 
            20                  25                  30          


Thr Thr Asn Tyr Leu Ile Glu Leu Ile Asp Arg Val Asp Asp Ile Tyr 
        35                  40                  45              


Arg Asn Thr Ser Trp Asp Asn Ala Gly Phe Lys Gly Tyr Gly Ile Gln 
    50                  55                  60                  


Ile Glu Gln Ile Arg Ile Leu Lys Ser Pro Gln Glu Val Lys Pro Gly 
65                  70                  75                  80  


Glu Lys His Tyr Asn Met Ala Lys Ser Tyr Pro Asn Glu Glu Lys Asp 
                85                  90                  95      


Ala Trp Asp Val Lys Met Leu Leu Glu Gln Phe Ser Phe Asp Ile Ala 
            100                 105                 110         


Glu Glu Ala Ser Lys Val Cys Leu Ala His Leu Phe Thr Tyr Gln Asp 
        115                 120                 125             


Phe Asp Met Gly Thr Leu Gly Leu Ala Tyr Val Gly Ser Pro Arg Ala 
    130                 135                 140                 


Asn Ser His Gly Gly Val Cys Pro Lys Ala Tyr Tyr Ser Pro Val Gly 
145                 150                 155                 160 


Lys Lys Asn Ile Tyr Leu Asn Ser Gly Leu Thr Ser Thr Lys Asn Tyr 
                165                 170                 175     


Gly Lys Thr Ile Leu Thr Lys Glu Ala Asp Leu Val Thr Thr His Glu 
            180                 185                 190         


Leu Gly His Asn Phe Gly Ala Glu His Asp Pro Asp Gly Leu Ala Glu 
        195                 200                 205             


Cys Ala Pro Asn Glu Asp Gln Gly Gly Lys Tyr Val Met Tyr Pro Ile 
    210                 215                 220                 


Ala Val Ser Gly Asp His Glu Asn Asn Lys Met Phe Ser Asn Cys Ser 
225                 230                 235                 240 


Lys Gln Ser Ile Tyr Lys Thr Ile Glu Ser Lys Ala Gln Glu Cys Phe 
                245                 250                 255     


Gln Glu Arg Ser 
            260 


<210>  31
<211>  89
<212>  PRT
<213>  artificial

<220>
<223>  Disintegrin domain of ADAM17

<400>  31

Asn Lys Val Cys Gly Asn Ser Arg Val Asp Glu Gly Glu Glu Cys Asp 
1               5                   10                  15      


Pro Gly Ile Met Tyr Leu Asn Asn Asp Thr Cys Cys Asn Ser Asp Cys 
            20                  25                  30          


Thr Leu Lys Glu Gly Val Gln Cys Ser Asp Arg Asn Ser Pro Cys Cys 
        35                  40                  45              


Lys Asn Cys Gln Phe Glu Thr Ala Gln Lys Lys Cys Gln Glu Ala Ile 
    50                  55                  60                  


Asn Ala Thr Cys Lys Gly Val Ser Tyr Cys Thr Gly Asn Ser Ser Glu 
65                  70                  75                  80  


Cys Pro Pro Pro Gly Asn Ala Glu Asp 
                85                  


<210>  32
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  Membrane proximal domain of ADAM17

<400>  32

Asp Thr Val Cys Leu Asp Leu Gly Lys Cys Lys Asp Gly Lys Cys Ile 
1               5                   10                  15      


Pro Phe Cys Glu Arg Glu Gln Gln Leu Glu Ser Cys Ala Cys Asn Glu 
            20                  25                  30          


Thr Asp Asn Ser Cys Lys Val Cys Cys Arg Asp Leu Ser Gly Arg Cys 
        35                  40                  45              


Val Pro Tyr Val Asp Ala Glu Gln Lys Asn Leu Phe Leu Arg Lys Gly 
    50                  55                  60                  


Lys Pro Cys Thr Val Gly Phe Cys Asp Met Asn Gly Lys Cys Glu Lys 
65                  70                  75                  80  


Arg Val Gln Asp Val Ile Glu Arg Phe Trp Asp Phe Ile Asp Gln Leu 
                85                  90                  95      


Ser Ile Asn Thr Phe Gly Lys Phe Leu Ala Asp Asn 
            100                 105             


<210>  33
<211>  452
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Chimeric (c) IgG1

<400>  33

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  34
<211>  452
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Chimeric (c) IgG1 AlaAla

<400>  34

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asn Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  35
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody light chain Chimeric (c) IgG1

<400>  35

Asp Val Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Lys Tyr Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Ala Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  36
<211>  1356
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Chimeric (c)

<400>  36
caggtgaccc tgaaggaaag cggacctggc attctgcagc catcacaaac actttcactg       60

acatgcagtt tttccggttt ttctctgaat accagcggga tgggggtcag ctggatccgc      120

cagcccagcg gtaagggact cgagtggctt gcccacatct attgggatga cgataagcgg      180

tacaacccct ccctcaaaag cagactgact attagtaaag acacttctag taatcaggtg      240

ttcttgaaga tcacctctct tgacacagcc gatactgcaa cttactactg cgctaggcga      300

tcccatttcg gcaactatta ctatgccatg gattattggg gccagggcac atctgtcaca      360

gttacctctg cttccaccaa gggcccttcc gtgttcccgc tagcccccag cagcaagagc      420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgtcct ggaacagcgg agccctgacc tccggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

acccagacct acatctgtaa cgtgaaccac aagcccagca acaccaaggt ggacaagaga      660

gtggagccca agagctgtga caagacccac acctgccccc cctgcccagc ccccgagctg      720

ctgggcggac ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      780

agaacccccg aggtgacctg tgtggtggtg gacgtgtccc acgaggaccc agaggtgaag      840

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc cagagaggag      900

cagtacaaca gcacctacag ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaagg agtacaagtg taaggtgtcc aacaaggccc tgccagcccc aatcgaaaag     1020

accatcagca aggccaaggg ccagccaaga gagccccagg tgtacaccct gccacccagc     1080

agggaggaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctaccca     1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

cccccagtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1260

agcagatggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagagcct gagcctgtcc ccaggc                               1356


<210>  37
<211>  1356
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Chimeric (c) AlaAla

<400>  37
caggtgaccc tgaaggaaag cggacctggc attctgcagc catcacaaac actttcactg       60

acatgcagtt tttccggttt ttctctgaat accagcggga tgggggtcag ctggatccgc      120

cagcccagcg gtaagggact cgagtggctt gcccacatct attgggatga cgataagcgg      180

tacaacccct ccctcaaaag cagactgact attagtaaag acacttctag taatcaggtg      240

ttcttgaaga tcacctctct tgacacagcc gatactgcaa cttactactg cgctaggcga      300

tcccatttcg gcaactatta ctatgccatg gattattggg gccagggcac atctgtcaca      360

gttacctctg cttccaccaa gggcccaagc gtgttccccc tggcccccag cagcaagagc      420

accagcggcg gcacagccgc cctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgtcct ggaacagcgg agccctgacc tccggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtgaccg tgcccagcag cagcctgggc      600

acccagacct acatctgtaa cgtgaaccac aagcccagca acaccaaggt ggacaagaga      660

gtggagccca agagctgtga caagacccac acctgccccc cctgcccagc ccccgaggcg      720

gcgggcggac ccagcgtgtt cctgttcccc cccaagccca aggacaccct gatgatcagc      780

agaacccccg aggtgacctg tgtggtggtg gacgtgtccc acgaggaccc agaggtgaag      840

ttcaactggt acgtggacgg cgtggaggtg cacaacgcca agaccaagcc cagagaggag      900

cagtacaaca gcacctacag ggtggtgtcc gtgctgaccg tgctgcacca ggactggctg      960

aacggcaagg agtacaagtg taaggtgtcc aacaaggccc tgccagcccc aatcgaaaag     1020

accatcagca aggccaaggg ccagccaaga gagccccagg tgtacaccct gccacccagc     1080

agggaggaga tgaccaagaa ccaggtgtcc ctgacctgtc tggtgaaggg cttctaccca     1140

agcgacatcg ccgtggagtg ggagagcaac ggccagcccg agaacaacta caagaccacc     1200

cccccagtgc tggacagcga cggcagcttc ttcctgtaca gcaagctgac cgtggacaag     1260

agcagatggc agcagggcaa cgtgttcagc tgctccgtga tgcacgaggc cctgcacaac     1320

cactacaccc agaagagcct gagcctgtcc ccaggc                               1356


<210>  38
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody light chain Chimeric (c)

<400>  38
gacgtccaaa tgacacagac aacttcttcc ctgagcgctt ccttgggtga tcgagtgacc       60

attagttgca gagcaagcca ggacatctct tcatacctca actggtatca gcaaaaacct      120

gatggcacct tcaagctgct tattttctac accagtcggt tgcagtctgg cgttccatca      180

aagtattccg gctctgggag tggcaccgac tactccctca ccatcagcaa tcttgagcaa      240

gaggatatcg cagcctattt ctgccagcag ggaaagacac tccccctgac tttcggggct      300

gggaccaagc tggaactgaa acgtacggtg gccgctccca gcgtgttcat cttcccccca      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  39
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain humanized (hz) consensus sequence


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Thr may be replaced by Gln

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Lys may be replaced by Gln

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Ile may be replaced by Leu

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Leu may be replaced by Val

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Gln may be replaced by Lys

<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  Gln may be replaced by Glu

<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Ser may be replaced by Thr

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Phe may be replaced by Val

<220>
<221>  VARIANT
<222>  (36)..(36)
<223>  Val may be replaced by Trp

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  Ser may be replaced by Ala

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Leu may be replaced by Ile

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Ala may be replaced by Gly

<220>
<221>  VARIANT
<222>  (52)..(52)
<223>  His may be replaced by Arg

<220>
<221>  VARIANT
<222>  (60)..(60)
<223>  Arg may be replaced by Asn

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Leu may be replaced by Val

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Ile may be replaced by Met

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Lys may be replaced by Val

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Ser may be replaced by Lys

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Val may be replaced by Phe

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  Phe may be replaced by Ser

<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Ile may be replaced by Leu

<220>
<221>  VARIANT
<222>  (85)..(85)
<223>  Thr may be replaced by Ser

<220>
<221>  VARIANT
<222>  (87)..(87)
<223>  Leu may be replaced by Val

<220>
<221>  VARIANT
<222>  (88)..(88)
<223>  Asp may be replaced by Thr

<220>
<221>  VARIANT
<222>  (89)..(89)
<223>  Thr may be replaced by Ala

<220>
<221>  VARIANT
<222>  (94)..(94)
<223>  Thr may be replaced by Val

<220>
<221>  VARIANT
<222>  (118)..(118)
<223>  Ser may be replaced by Thr

<220>
<221>  VARIANT
<222>  (122)..(122)
<223>  Thr may be replaced by Ser

<400>  39

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Thr Ser 
        115                 120             


<210>  40
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Hz variable domain

<400>  40

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  41
<211>  452
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Hz full IgG1

<400>  41

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly 
    450         


<210>  42
<211>  448
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Hz full IgG2

<400>  42

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
    210                 215                 220                 


Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


<210>  43
<211>  469
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Hz full IgG3

<400>  43

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys 
    210                 215                 220                 


Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys Pro Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr 
                405                 410                 415     


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly 
465                 


<210>  44
<211>  449
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Hz full IgG4

<400>  44

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Asp Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Met Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Ser His Phe Gly Asn Tyr Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
        195                 200                 205             


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
    210                 215                 220                 


Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
        435                 440                 445             


Gly 
    


<210>  45
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody light chain humanized (hz) consensus sequence


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Val may be replaced by Ile

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Thr may be replaced by Ser

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Thr may be replaced by Pro

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Leu may be replaced by Val

<220>
<221>  VARIANT
<222>  (22)..(22)
<223>  Ser may be replaced by Thr

<220>
<221>  VARIANT
<222>  (41)..(41)
<223>  Asp may be replaced by Gly

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  Gly may be replaced by Lys

<220>
<221>  VARIANT
<222>  (43)..(43)
<223>  Thr may be replaced by Ala

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  Phe may be replaced by Pro

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Phe may be replaced by Tyr

<220>
<221>  VARIANT
<222>  (53)..(53)
<223>  Arg may be replaced by Ser

<220>
<221>  VARIANT
<222>  (61)..(61)
<223>  Lys may be replaced by Arg

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  Tyr may be replaced by Phe

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Tyr may be replaced by Phe

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Ser may be replaced by Thr

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  Asn may be replaced by Ser

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  Glu may be replaced by Gln

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Gln may be replaced by Pro

<220>
<221>  VARIANT
<222>  (83)..(83)
<223>  Ile may be replaced by Phe

<220>
<221>  VARIANT
<222>  (85)..(85)
<223>  Ala may be replaced by Thr

<220>
<221>  VARIANT
<222>  (87)..(87)
<223>  Phe may be replaced by Tyr

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  Ala may be replaced by Gly

<220>
<221>  VARIANT
<222>  (104)..(104)
<223>  Leu may be replaced by Val

<220>
<221>  VARIANT
<222>  (106)..(106)
<223>  Leu may be replaced by Ile

<400>  45

Asp Val Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Phe Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Lys Tyr Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Ala Tyr Phe Cys Gln Gln Gly Lys Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  46
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody light chain Hz variable domain

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  47
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  1022C3 antibody light chain Hz full

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Lys Thr Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  48
<211>  369
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody heavy chain Hz variable domain

<400>  48
caagttcagt tgcaggaatc cggtcctggt cttgttaagc cttccgagac tttgtccctc       60

acttgtaccg tgtccggctt tagccttgac actagcggaa tgggagtgag ttggatcagg      120

cagcccgcag gaaaaggcct ggagtggatt ggccatatat actgggatga tgataaaagg      180

tacaacccca gcctgaagtc acgtgtgaca atgagcaaag acacatctag caatcaggtg      240

agtctgaaac tgtcttctgt gaccgccgct gacaccgctg tgtactactg cgcccggcgc      300

tctcattttg ggaattatta ttatgccatg gactattggg ggcagggcac aaccgtcacc      360

gtgtcatca                                                              369


<210>  49
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  1022C3 antibody light chain Hz variable domain

<400>  49
gacatccaga tgacccaatc cccatcatcc ttgagcgctt cagtgggaga tagggtaacc       60

atcacctgca gggcatctca ggatatcagc tcttacctga actggtacca gcagaagccc      120

ggaaaggccc ctaaattgct gattttctac accagccgcc tgcagagtgg agttcctagt      180

cggttttccg gcagtggctc tgggactgat ttcactctga ctattagctc tctgcagccc      240

gaagacttcg ccacatatta ttgccagcag gggaagacac tccccctgac atttggcggg      300

ggcacaaaag tggagataaa g                                                321


<210>  50
<211>  97
<212>  PRT
<213>  artificial

<220>
<223>  Germline IGHV4-4*07

<400>  50

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Thr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  51
<211>  95
<212>  PRT
<213>  artificial

<220>
<223>  Germline IGKV1-39*01

<400>  51

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro 
                85                  90                  95  


<210>  52
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Germline IGHJ6*01

<400>  52

Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
1               5                   10                  15      


Thr Val Ser Ser 
            20  


<210>  53
<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  Germline IGKJ4*01

<400>  53

Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10          


