SEQUENCE LISTING

<110>   4D Pharma Research Ltd

<120>   Polypeptide and immune modulation

<130>   P067638WO

<150>	GB 1423083.3
<151>	2014-12-23

<160>   8

<210>   1
<211>   705
<212>   DNA
<213>   Bacteroides thetaiotaomicron VPI-5482

<400>   1
atgaaaaaag taatcgacag agcttcatca agaggctatt ttaatcatgg ctggctcaaa  60
acccaccaca cattcagttt tgctaactat tacaatccgg aaagaatcca tttcggagcc  120
ttgcgagtgc tgaatgatga cagtgtagac ccgtcgatgg gatttgatac tcatccacat  180
aaaaatatgg aagtaatttc cattccgttg aaagggtatc tgagacatgg cgacagtgta  240
caaaatacga aaacgattac tcccggtgat atccaagtga tgagtacggg cagtggtatc  300
tatcatagtg agtataacga cagcaaggaa gaacaattgg aattcctgca aatatgggta  360
ttcccccgaa tcgagaatac gaaacccgaa tataacaatt tcgatatacg tccgctgctg  420
aaaccgaacg agttatctct gttcatttca ccgaacggca agacaccggc ctccatcaaa  480
caggatgcct ggttctctat gggagacttc gatacggaaa gaaccatcga atattgtatg  540
catcaggaag gtaacggagc ttatctgttt gtgatagaag gagagatcag cgtggccgat  600
gaacatctgg ccaaacgtga cggcatcgga atatgggata ccaaaagctt ctctatccgt  660
gctactaaag ggaccaaact tctggtaatg gaagtaccca tgtaa                  705

<210>   2
<211>   234
<212>   PRT
<213>   Bacteroides thetaiotaomicron VPI-5482

<400>   2
Met Lys Lys Val Ile Asp Arg Ala Ser Ser Arg Gly Tyr Phe Asn His 
1               5                   10                  15      

Gly Trp Leu Lys Thr His His Thr Phe Ser Phe Ala Asn Tyr Tyr Asn 
            20                  25                  30          

Pro Glu Arg Ile His Phe Gly Ala Leu Arg Val Leu Asn Asp Asp Ser 
        35                  40                  45              

Val Asp Pro Ser Met Gly Phe Asp Thr His Pro His Lys Asn Met Glu 
    50                  55                  60                  

Val Ile Ser Ile Pro Leu Lys Gly Tyr Leu Arg His Gly Asp Ser Val 
65                  70                  75                  80  

Gln Asn Thr Lys Thr Ile Thr Pro Gly Asp Ile Gln Val Met Ser Thr 
                85                  90                  95      

Gly Ser Gly Ile Tyr His Ser Glu Tyr Asn Asp Ser Lys Glu Glu Gln 
            100                 105                 110         

Leu Glu Phe Leu Gln Ile Trp Val Phe Pro Arg Ile Glu Asn Thr Lys 
        115                 120                 125             

Pro Glu Tyr Asn Asn Phe Asp Ile Arg Pro Leu Leu Lys Pro Asn Glu 
    130                 135                 140                 

Leu Ser Leu Phe Ile Ser Pro Asn Gly Lys Thr Pro Ala Ser Ile Lys 
145                 150                 155                 160 

Gln Asp Ala Trp Phe Ser Met Gly Asp Phe Asp Thr Glu Arg Thr Ile 
                165                 170                 175     

Glu Tyr Cys Met His Gln Glu Gly Asn Gly Ala Tyr Leu Phe Val Ile 
            180                 185                 190         

Glu Gly Glu Ile Ser Val Ala Asp Glu His Leu Ala Lys Arg Asp Gly 
        195                 200                 205             

Ile Gly Ile Trp Asp Thr Lys Ser Phe Ser Ile Arg Ala Thr Lys Gly 
    210                 215                 220                 

Thr Lys Leu Leu Val Met Glu Val Pro Met 
225                 230                 

<210>   3
<211>   720
<212>   DNA
<213>   Artificial Sequence 

<220>
<223> 	B. thetaiotaomicron VPI-5482 sequence codon optimised for expression in E. coli

<400>   3
ggtaccatga aaaaagtgat tgatcgtgcg agcagccgtg gctattttaa ccatggctgg  60
ctgaaaaccc atcatacctt tagcttcgcg aactattata atccggaacg cattcatttt  120
ggcgcgctgc gtgtgctgaa cgatgatagc gtggatccga gcatgggctt tgatacccat  180
ccgcacaaaa acatggaagt gattagcatt ccgctgaaag gctatctgcg tcatggcgat  240
agcgtgcaga acaccaaaac cattaccccg ggtgatattc aggtgatgag caccggcagc  300
ggcatttatc atagcgaata caacgatagc aaagaagaac agctggaatt tctgcagatt  360
tgggtgtttc cgcgtattga aaacaccaaa ccggaatata acaactttga tattcgcccg  420
ctgctgaaac cgaacgaact gagcctgttt attagcccga acggcaaaac cccggcgagc  480
attaaacagg atgcgtggtt tagcatgggc gattttgata ccgaacgcac cattgaatat  540
tgcatgcatc aggaaggcaa cggcgcgtac ctgtttgtga ttgaaggcga aattagcgtg  600
gcggatgaac atctggccaa acgtgatggc attggcattt gggataccaa aagcttcagc  660
attcgtgcga ccaaaggcac caaactgctg gtgatggaag tgccgatgta ataagagctc  720

<210>   4
<211>   238
<212>   PRT
<213>   Artificial Sequence

<220>
<223> 	B. thetaiotaomicron VPI-5482 sequence codon optimised for expression in E. coli

<400>   4
Gly Thr Met Lys Lys Val Ile Asp Arg Ala Ser Ser Arg Gly Tyr Phe 
1               5                   10                  15      

Asn His Gly Trp Leu Lys Thr His His Thr Phe Ser Phe Ala Asn Tyr 
            20                  25                  30          

Tyr Asn Pro Glu Arg Ile His Phe Gly Ala Leu Arg Val Leu Asn Asp 
        35                  40                  45              

Asp Ser Val Asp Pro Ser Met Gly Phe Asp Thr His Pro His Lys Asn 
    50                  55                  60                  

Met Glu Val Ile Ser Ile Pro Leu Lys Gly Tyr Leu Arg His Gly Asp 
65                  70                  75                  80  

Ser Val Gln Asn Thr Lys Thr Ile Thr Pro Gly Asp Ile Gln Val Met 
                85                  90                  95      

Ser Thr Gly Ser Gly Ile Tyr His Ser Glu Tyr Asn Asp Ser Lys Glu 
            100                 105                 110         

Glu Gln Leu Glu Phe Leu Gln Ile Trp Val Phe Pro Arg Ile Glu Asn 
        115                 120                 125             

Thr Lys Pro Glu Tyr Asn Asn Phe Asp Ile Arg Pro Leu Leu Lys Pro 
    130                 135                 140                 

Asn Glu Leu Ser Leu Phe Ile Ser Pro Asn Gly Lys Thr Pro Ala Ser 
145                 150                 155                 160 

Ile Lys Gln Asp Ala Trp Phe Ser Met Gly Asp Phe Asp Thr Glu Arg 
                165                 170                 175     

Thr Ile Glu Tyr Cys Met His Gln Glu Gly Asn Gly Ala Tyr Leu Phe 
            180                 185                 190         

Val Ile Glu Gly Glu Ile Ser Val Ala Asp Glu His Leu Ala Lys Arg 
        195                 200                 205             

Asp Gly Ile Gly Ile Trp Asp Thr Lys Ser Phe Ser Ile Arg Ala Thr 
    210                 215                 220                 

Lys Gly Thr Lys Leu Leu Val Met Glu Val Pro Met Glu Leu 
225                 230                 235             

<210>   5
<211>   720
<212>   DNA
<213>   Artificial Sequence

<220>
<223> 	B. thetaiotaomicron VPI-5482 sequence codon optimised for expression in L. lactis

<400>   5
ggtaccatga aaaaagttat tgatcgtgct tcatcacgtg gatattttaa tcatggatgg  60
cttaaaactc atcatacatt tagttttgcc aattattata atccagaacg tattcatttt  120
ggtgctcttc gtgttcttaa tgatgattca gttgatccat caatgggatt tgatacacat  180
ccacataaaa atatggaagt tatttcaatt ccacttaaag gatatcttcg tcatggtgat  240
tcagttcaaa atacaaaaac aattacacct ggagatattc aagttatgtc tacaggatca  300
ggaatttatc attcagaata taatgattca aaagaagaac aacttgaatt tcttcaaatt  360
tgggtctttc cacgtattga aaatacaaaa ccagaatata ataatttcga cattcgtcca  420
cttcttaaac caaatgaact ttcacttttt atctcaccaa atggaaaaac accagcttca  480
attaaacaag atgcttggtt ttcaatggga gattttgata cagaacgtac aattgaatat  540
tgtatgcatc aagaaggtaa cggcgcttat ctttttgtta ttgaaggtga aatttcagtt  600
gctgatgaac atcttgctaa acgtgatgga attggaattt gggatacaaa atcattttca  660
attcgtgcta caaaaggtac aaaacttctt gttatggaag ttccaatgta ataagagctc  720

<210>   6
<211>   238
<212>   PRT
<213>   Artificial Sequence

<220>
<223> 	B. thetaiotaomicron VPI-5482 sequence codon optimised for expression in L. lactis

<400>   6
Gly Thr Met Lys Lys Val Ile Asp Arg Ala Ser Ser Arg Gly Tyr Phe 
1               5                   10                  15      

Asn His Gly Trp Leu Lys Thr His His Thr Phe Ser Phe Ala Asn Tyr 
            20                  25                  30          

Tyr Asn Pro Glu Arg Ile His Phe Gly Ala Leu Arg Val Leu Asn Asp 
        35                  40                  45              

Asp Ser Val Asp Pro Ser Met Gly Phe Asp Thr His Pro His Lys Asn 
    50                  55                  60                  

Met Glu Val Ile Ser Ile Pro Leu Lys Gly Tyr Leu Arg His Gly Asp 
65                  70                  75                  80  

Ser Val Gln Asn Thr Lys Thr Ile Thr Pro Gly Asp Ile Gln Val Met 
                85                  90                  95      

Ser Thr Gly Ser Gly Ile Tyr His Ser Glu Tyr Asn Asp Ser Lys Glu 
            100                 105                 110         

Glu Gln Leu Glu Phe Leu Gln Ile Trp Val Phe Pro Arg Ile Glu Asn 
        115                 120                 125             

Thr Lys Pro Glu Tyr Asn Asn Phe Asp Ile Arg Pro Leu Leu Lys Pro 
    130                 135                 140                 

Asn Glu Leu Ser Leu Phe Ile Ser Pro Asn Gly Lys Thr Pro Ala Ser 
145                 150                 155                 160 

Ile Lys Gln Asp Ala Trp Phe Ser Met Gly Asp Phe Asp Thr Glu Arg 
                165                 170                 175     

Thr Ile Glu Tyr Cys Met His Gln Glu Gly Asn Gly Ala Tyr Leu Phe 
            180                 185                 190         

Val Ile Glu Gly Glu Ile Ser Val Ala Asp Glu His Leu Ala Lys Arg 
        195                 200                 205             

Asp Gly Ile Gly Ile Trp Asp Thr Lys Ser Phe Ser Ile Arg Ala Thr 
    210                 215                 220                 

Lys Gly Thr Lys Leu Leu Val Met Glu Val Pro Met Glu Leu 
225                 230                 235             

<210>   7
<211>   234
<212>   PRT
<213>   Bacteroides thetaiotaomicron VPI-5482

<400>   7
Met Lys Lys Val Ile His Lys Ala Asp Thr Arg Gly His Ser Gln Tyr 
1               5                   10                  15      

Asp Trp Leu Asp Ser Tyr His Thr Phe Ser Phe Asp Glu Tyr Phe Asp 
            20                  25                  30          

Ser Asp Arg Ile Asn Phe Gly Ala Leu Arg Val Leu Asn Asp Asp Lys 
        35                  40                  45              

Val Ala Pro Gly Glu Gly Phe Gln Thr His Pro His Lys Asn Met Glu 
    50                  55                  60                  

Ile Ile Ser Ile Pro Leu Lys Gly His Leu Gln His Gly Asp Ser Lys 
65                  70                  75                  80  

Lys Asn Ser Arg Ile Ile Thr Val Gly Glu Ile Gln Thr Met Ser Ala 
                85                  90                  95      

Gly Thr Gly Ile Phe His Ser Glu Val Asn Ala Ser Pro Val Glu Pro 
            100                 105                 110         

Val Glu Phe Leu Gln Ile Trp Ile Met Pro Arg Glu Arg Asn Thr His 
        115                 120                 125             

Pro Val Tyr Lys Asp Phe Ser Ile Lys Glu Leu Glu Arg Pro Asn Glu 
    130                 135                 140                 

Leu Ala Val Ile Val Ser Pro Asp Gly Ser Thr Pro Ala Ser Leu Leu 
145                 150                 155                 160 

Gln Asp Thr Trp Phe Ser Ile Gly Lys Val Glu Ala Gly Lys Lys Leu 
                165                 170                 175     

Gly Tyr His Leu His Gln Ser His Gly Gly Val Tyr Ile Phe Leu Ile 
            180                 185                 190         

Glu Gly Glu Ile Val Val Asp Gly Glu Val Leu Lys Arg Arg Asp Gly 
        195                 200                 205             

Met Gly Val Tyr Asp Thr Lys Ser Phe Glu Leu Glu Thr Leu Lys Asp 
    210                 215                 220                 

Ser His Ile Leu Leu Ile Glu Val Pro Met 
225                 230                 

<210>   8
<211>   234
<212>   PRT
<213>   Bacteroides thetaiotaomicron CAG:40

<400>   8
Met Lys Lys Val Ile His Lys Ala Asp Thr Arg Gly His Ser Gln Tyr 
1               5                   10                  15      

Asp Trp Leu Asp Ser Tyr His Thr Phe Ser Phe Asp Glu Tyr Phe Asp 
            20                  25                  30          

Ser Asp Arg Ile Asn Phe Gly Ala Leu Arg Val Leu Asn Asp Asp Lys 
        35                  40                  45              

Val Ala Pro Gly Glu Gly Phe Gln Thr His Pro His Lys Asn Met Glu 
    50                  55                  60                  

Ile Ile Ser Ile Pro Leu Lys Gly His Leu Gln His Gly Asp Ser Lys 
65                  70                  75                  80  

Lys Asn Ser Arg Ile Ile Thr Val Gly Glu Ile Gln Thr Met Ser Ala 
                85                  90                  95      

Gly Thr Gly Ile Phe His Ser Glu Val Asn Ala Ser Pro Val Glu Pro 
            100                 105                 110         

Val Glu Phe Leu Gln Ile Trp Ile Met Pro Arg Glu Arg Asn Thr His 
        115                 120                 125             

Pro Val Tyr Lys Asp Phe Ser Ile Lys Glu Leu Glu Arg Pro Asn Glu 
    130                 135                 140                 

Leu Ala Val Ile Val Ser Pro Asp Gly Ser Thr Pro Ala Ser Leu Leu 
145                 150                 155                 160 

Gln Asp Thr Trp Phe Ser Ile Gly Lys Val Glu Ala Gly Lys Lys Leu 
                165                 170                 175     

Gly Tyr His Leu His Gln Ser His Gly Gly Val Tyr Ile Phe Leu Ile 
            180                 185                 190         

Glu Gly Glu Ile Val Val Asp Gly Glu Val Leu Lys Arg Arg Asp Gly 
        195                 200                 205             

Met Gly Val Tyr Asp Thr Lys Ser Phe Glu Leu Glu Thr Leu Lys Asp 
    210                 215                 220                 

Ser His Ile Leu Leu Ile Glu Val Pro Met 
225                 230                 

