                         SEQUENCE LISTING

<110>   UNIVERSITA' DEGLI STUDI DI PARMA 

<120>  Anti-NG2/CSPG4 pro-apoptotic antibodies and their uses for desease therapy

<130>  21.U0023A.12.WO.1

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2161D2 clone antibody 
       (protein)

<400>  1

Gln Val Lys Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Lys Leu Pro Ser Leu Cys Tyr Gly Leu Leu Gly Ser Arg 
                85                  90                  95      


Asp Leu Ser His Arg Leu Leu Ser Gln Asn Asp Thr Pro Ile Cys Leu 
            100                 105                 110         


<210>  2
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2161D2 clone antibody 
       (DNA)

<400>  2
caggtcaagc tggagcagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatac attagtagtg gcagtagtac cctccactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga aactaccctc actatgctat ggactactgg ggtcaaggga cctcagtcac      300

cgtctcctca gccaaaacga cacccccatc tgtcta                                336


<210>  3
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2161D2 clone antibody 
       (Protein)

<400>  3

Asp Ile Val Leu Thr Gln Thr Asn Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Tyr Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Asn Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Val Ser Asn Leu Glu Ser Gly Val Pro Val 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ile Arg 
                85                  90                  95      


Glu Leu Thr Arg Ser Glu Gly Gly Pro Ser Trp Lys 
            100                 105             


<210>  4
<211>  356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2161D2 clone antibody 
       (DNA)

<400>  4
gatattgtgc tcacccaaac taacgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcataca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggaac      120

caacagaaac caggacagcc acccagactc ctcatctatc ttgtatccaa cctagaatct      180

ggggtccctg tcaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acattaggga gcttacacgt      300

tcggaggggg gaccaagctg gaaataaaac gggctgatgc tgcaccaact gtatcc          356


<210>  5
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2164H5 clone antibody 
       (Protein)

<400>  5

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Ser Ser Thr Leu His Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Lys Leu Pro Ser Leu Cys Tyr Gly Leu Leu Gly Ser Arg 
                85                  90                  95      


Asn Leu Ser His Arg Leu Leu Ser Gln Asn Asp Thr Pro Ile Cys Leu 
            100                 105                 110         


<210>  6
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2164H5 clone antibody 
       (DNA)

<400>  6
gaagttcagc tgcaggagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggaa tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatac attagtagtg gcagtagtac cctccactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctgttc      240

ctgcaaatga aactaccctc actatgctat ggactactgg ggtcaaggaa cctcagtcac      300

cgtctcctca gccaaaacga cacccccatc tgtctat                               337


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2164H5  clone antibody 
       (Protein)

<400>  7

Asp Ile Val Ile Thr Gln Ser Asn Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Ser Arg Ala Ser Glu Ser Leu Glu Tyr Tyr 
            20                  25                  30          


Gly Ile Ser Leu Met His Trp Tyr Leu Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Ser Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120 


<210>  8
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2164H5 clone antibody 
       (DNA)

<400>  8
gatattgtga tcacccagtc taacgcctct ttggctgtgt ctctggggca gagagccacc       60

atctccagca gagccagtga aagtcttgaa tattatggca taagtttaat gcactggtac      120

ctacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tcagggacag acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccttcg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgggctg atgctgcacc aactgtatcc      360


<210>  9
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2172B12 clone antibody 
       (Protein)

<400>  9

Glu Val Gln Leu Glu Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Ile Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ala Met Ser Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Asn Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Val Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Tyr Tyr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125 


<210>  10
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2172B12 clone antibody 
       (DNA)

<400>  10
gaagtccagc tggagcagtc agggggaggc cttgtgaagc ctggagggtc cctaaaactc       60

tcctgtgcag cctctggaat tactttcagt ggctatgcca tgtcttggat tcgccagact      120

ccggagaaga gactggagtg ggtcgcaacc attagtagtg gtggtaatta cacctactat      180

ccagacactg tgaaggggcg tttcaccatc tccagagaca atgccaaaaa caccctatac      240

ttacaagtga gcagtctgag gtctgaggac acggccatat attactgtgc aagactttac      300

tacggattcg actactgggg ccaaggcacc actctcacag tctcctcagc caaaacgaca      360

cccccatctg tctat                                                       375


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2172B12 clone antibody 
       (Protein)

<400>  11

Asp Ile Val Leu Thr Gln Ser Asn Lys Ile Met Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly His Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Arg Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Thr Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr His Ser Tyr Pro Leu 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser 
        115         


<210>  12
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2172B12 clone antibody 
       (DNA)

<400>  12
gacattgtgc tcacccaatc taacaaaatc atgtccgcat cagtaggaga ccgggtcagt       60

gtcacctgca aggccagtca gaatgtggat agtaatgtgg cctggtatca acagaaacct      120

ggacattctc ccaaagcact aatttattcg gcatcctacc ggtacagtag agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcaccaa tgtgcagtct      240

gaagacttgg cagactattt ctgtcagcaa tatcacagct atcctcttct cacgttcggt      300

gctgggacca agctggagct gaaacgggct gatgctgcac caactgtatc c               351


<210>  13
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2166G4 clone antibody 
       (Protein)

<400>  13

Glu Val Gln Leu Glu Glu Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Thr Asn Gly Asn Thr Asp Phe Asn Glu Asn Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Arg Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Lys Tyr Gly Tyr Ala Trp Phe Ala Tyr Trp Gly Arg Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr 
        115                 120                 125             


<210>  14
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region sequence of 2166G4 clone antibody 
       (DNA)

<400>  14
gaggtccagc tggaggagtc tggggctgaa ctggtgaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta ctccttcacc agctactata tgtactgggt gaaggagagg      120

cctggacaag gccttgagtg gattgggggg atcaatccta ccaatggtaa tactgacttc      180

aatgagaact tcaagaacaa ggccacactg actgtagaca aatcctccag cacagtctat      240

atgcgactca gcggcctgac atctgaggac tctgcggtct attattgttc aagatctaaa      300

tatggttacg cctggtttgc ttactggggc cgagggactc tggtcactgt ctctgcagcc      360

aaaacgacac ccccatctgt ctat                                             384


<210>  15
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2166G4 clone antibody 
       (Protein)

<400>  15

Asp Ile Val Leu Thr Gln Ser His Ala Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Ala Ile Ser Cys Arg Ser Ser Gln Ser Val Asn Thr Ser 
            20                  25                  30          


Ala Tyr Ser Tyr Val His Ser Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Val Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Ser Val Glu Glu Glu Asp Pro Thr Thr Tyr Asp Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile His Ser Arg Ser Ala Arg Gly Gln Ser Trp Lys Tyr Asn Gly 
            100                 105                 110         


Leu Met Leu Gln Thr Val Ser 
        115                 


<210>  16
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region sequence of 2166G4 clone antibody 
       (DNA)

<400>  16
gacattgtgc tgacccaatc tcacgcttcc ttaactgtat ctctggggca gagggccgcc       60

atctcatgca ggtccagcca aagtgtcaat acatctgcct atagttatgt gcactcctac      120

caacagagac caggccagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tgtcagtggg tctgggacag acttcaccct caacatccat      240

tctgtggagg aggaggatcc tacaacatat gactgtcagc acagttggga gattcattca      300

cgttcggctc gggggcaaag ttggaaatat aacgggctga tgctgcaaac tgtatcc         357


<210>  17
<211>  2322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NG2/CSPG4 ectodomain

<400>  17

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Heavy chain variable region 2161D2

<400>  18
ggattcactt tcagtagctt tgga                                              24


<210>  19
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Heavy chain variable region 2161D2

<400>  19
attagtagtg gcagtagtac cctc                                              24


<210>  20
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Light chain variable region 2161D2

<400>  20
aaaagtgtca gtacatctgg ctatagttat                                        30


<210>  21
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Light chain variable region 2161D2

<400>  21
cttgtatcc                                                                9


<210>  22
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 Light chain variable region 2161D2

<400>  22
cagcacatta gggagcttac acgt                                              24


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Heavy chain variable region 2164H5

<400>  23
ggattcactt tcagtagctt tgga                                              24


<210>  24
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Heavy chain variable region 2164H5

<400>  24
attagtagtg gcagtagtac cctc                                              24


<210>  25
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Light chain variable region 2164H5

<400>  25
gaaagtcttg aatattatgg cataagttta                                        30


<210>  26
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Light chain variable region 2164H5

<400>  26
gctgcatcc                                                                9


<210>  27
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 Light chain variable region 2164H5

<400>  27
cagcaaagta ggaaggttcc ttcgacg                                           27


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Heavy chain variable region 2166G4

<400>  28
ggctactcct tcaccagcta ctat                                              24


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Heavy chain variable region 2166G4

<400>  29
atcaatccta ccaatggtaa tact                                              24


<210>  30
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 Heavy chain variable region 2166G4

<400>  30
tcaagatcta aatatggtta cgcctgg                                           27


<210>  31
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Light chain variable region 2166G4

<400>  31
caaagtgtca atacatctgc ctatagttat                                        30


<210>  32
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Light chain variable region 2166G4

<400>  32
tatgcatcc                                                                9


<210>  33
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 Light chain variable region 2166G4

<400>  33
cagcacagtt gggagattca ttcacgt                                           27


<210>  34
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Heavy chain variable region 2172B12

<400>  34
ggaattactt tcagtggcta tgcc                                              24


<210>  35
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Heavy chain variable region 2172B12

<400>  35
attagtagtg gtggtaatta cacc                                              24


<210>  36
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 Heavy chain variable region 2172B12

<400>  36
gcaagacttt actacggatt cgactac                                           27


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR1 Light chain variable region 2172B12

<400>  37
cagaatgtgg atagtaat                                                     18


<210>  38
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR2 Light chain variable region 2172B12

<400>  38
tcggcatcc                                                                9


<210>  39
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDR3 Light chain variable region 2172B12

<400>  39
cagcaatatc acagctatcc tcttctcacg                                        30


