                         SEQUENCE LISTING

<110>  CASE WESTERN RESERVE UNIVERSITY
 
<120>  INSULIN ANALOGUES OF ENHANCED STABILITY AND REDUCED MITOGENICITY

<130>  200512.00322

<150>  62/096,776
<151>  2014-12-24

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is any amino acid other than Val, Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu, Trp or Tyr

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is Tyr or Glu

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Asn, Asp, Ala or Gly

<400>  4

Gly Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Xaa Xaa Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Xaa 
            20      


<210>  5
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Xaa is Phe-Val-Asn, Val-Asn,  Asn or 0 amino acids

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Phe or a halogenated Phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Pro, Lys, Ala, or Gln

<220>
<221>  MISC_FEATURE
<222>  (31)..(32)
<223>  Xaa is 0-2 amino acids wherein at least one amino acid residue is
       Glu or Asp, if present

<400>  5

Xaa Xaa Xaa Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Xaa Glu Thr Xaa Xaa 
            20                  25                  30          


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  7
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Ile Val Glu Gln Cys Cys Glu Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  8
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
            20                  25                  30          


<210>  9
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is ortho fluoro Phe

<400>  9

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  10
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Xaa is Phe-Val-Asn, Val-Asn, Asn or 0 amino acids

<400>  10

Xaa Xaa Xaa Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  11
<211>  32
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Xaa is Phe-Val-Asn, Val-Asn, Asn or 0 amino acids

<400>  11

Xaa Xaa Xaa Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Glu Thr Glu Glu 
            20                  25                  30          


<210>  12
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  Xaa is Phe-Val-Asn, Val-Asn, Asn or 0 amino acids

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is ortho fluoro Phe

<400>  12

Xaa Xaa Xaa Gln His Leu Cys Gly Ser Asp Leu Ala Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Xaa Phe Tyr Thr Pro Glu Thr 
            20                  25                  30  


<210>  13
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  13
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  14
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  14
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctaaggct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  15
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  15
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  16
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  16
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cattgtacca attggagaac tactgcaact aatagttcta c               171


<210>  17
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  17
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  18
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is  TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  18
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  19
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  19
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctaaggct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  20
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is  TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is  TAT, TAC, GAA or GAG

<400>  20
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  21
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is  TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is  TAT, TAC, GAA or GAG

<400>  21
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  22
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  22
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  23
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  23
aargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  24
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  24
aargtcaatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctaaggct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  25
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  25
aargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  26
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  26
aargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  27
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  27
aargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  28
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  28
ttcaaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  29
<211>  161
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (132)..(134)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (135)..(137)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  29
ttcaaratca acacttgtgt ggtagtgact tggcagaggc tttgtacttg gtctgtggtg       60

agagaggatt cttctacacc cctaaggctg ctaagggaat cgttgagcaa tgctgtactt      120

ccatctgctc annnnnncaa ttggagaact actgcaacta a                          161


<210>  30
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  30
ttcaaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  31
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  31
ttcaaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  32
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  32
ttcaaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  33
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  33
ttcgtcaarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  34
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  34
ttcgtcaarc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctaaggct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  35
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  35
ttcgtcaarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  36
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  36
ttcgtcaarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  37
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  37
ttcgtcaarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaaaggag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  38
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  38
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccagargag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  39
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  39
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctgargct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  40
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  40
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccagargag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  41
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  41
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccagargag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  42
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  42
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccagargag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cattgtacca attggagaac tactgcaact aa                         162


<210>  43
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  43
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccagargag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  44
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  44
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctgargct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  45
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  45
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccagargag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  46
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  46
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccagargag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  47
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  47
ttcgtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccagargag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  48
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  48
gargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaagarag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  49
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  49
gargtcaatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctagarct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  50
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  50
gargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaagarag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  51
<211>  161
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (132)..(134)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (135)..(137)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  51
gargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctaccc ccaagaragt ggaagggtat cgttgagcaa tgttgtactt      120

ccatctgctc annnnnncaa ttggagaact actgcaacta a                          161


<210>  52
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  52
gargtcaatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tagttctacc cccaagarag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  53
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  53
ttcgaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaagarag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  54
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  54
ttcgaraatc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctagarct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  55
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  55
ttcgaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccaagarag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  56
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  56
ttcgaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaagarag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  57
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  57
ttcgaraatc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccaagarag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  58
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  58
ttcgtcgarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccagargag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  59
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  59
ttcgtcgarc aacacttgtg tggtagtgac ttggcagagg ctttgtactt ggtctgtggt       60

gagagaggat tcttctacac ccctgargct gctaagggaa tcgttgagca atgctgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  60
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  60
ttcgtcgarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat tcttctacac cccagargag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  61
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  61
ttcgtcgarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccagargag tggaagggta tcgttgagca atgttgtact      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


<210>  62
<211>  162
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (133)..(135)
<223>  NNN is TTA, TTG, CTT, CTC, CTG, TAT, TAC, or TGG

<220>
<221>  misc_feature
<222>  (136)..(138)
<223>  NNN is TAT, TAC, GAA or GAG

<400>  62
ttcgtcgarc aacacttgtg tggtagtgac ttggcagagg cattgtactt ggtctgtggt       60

gagagaggat agttctacac cccagargag tggaagggta tcgttgagca atgttgtgaa      120

tccatctgct cannnnnnca attggagaac tactgcaact aa                         162


