
                                SEQUENCE LISTING

<110> Enumeral Biomedical Holdings, Inc.
      

<120> Anti-PD-1 Antibodies
  

<130> 5091.1000005

<150> US 62/095,675       
<151> 2014-12-22  

<150> US 62/220,199       
<151> 2015-09-17  

<150> us 62/251,082       
<151> 2015-11-04  

<150> US 62/261,118       
<151> 2015-11-30  

<160> 97

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 120
<212> PRT
<213> Mus musculus

<400> 1
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Thr Asn Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 2
<211> 120
<212> PRT
<213> Mus musculus

<400> 2
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Glu Pro Ser Ser Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 3
<211> 120
<212> PRT
<213> Mus musculus

<400> 3
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Asp Pro Tyr Ser Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ile Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Asp Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 4
<211> 120
<212> PRT
<213> Mus musculus

<400> 4
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Ala Thr Leu Asn Val Asp Lys Ser Ser Lys Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Asp Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Ser Val Thr Val Ser Ser
        115                 120 


<210> 5
<211> 117
<212> PRT
<213> Mus musculus

<400> 5
Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Met Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Ile Asp Thr Ser Asp Ser Tyr Thr Ser Tyr His Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Glu Asp Glu Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg Asp Tyr Gly Gly Phe Gly Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110         
Leu Thr Val Ser Ser
        115         


<210> 6
<211> 116
<212> PRT
<213> Mus musculus

<400> 6
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Lys Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 7
<211> 116
<212> PRT
<213> Mus musculus

<400> 7
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Arg Ala Ser Gly Tyr Ile Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Asp Lys Thr Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 8
<211> 116
<212> PRT
<213> Mus musculus

<400> 8
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Asn His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Asp Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 9
<211> 116
<212> PRT
<213> Mus musculus

<400> 9
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Ser Gly Gly Ser Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Arg Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 10
<211> 116
<212> PRT
<213> Mus musculus

<400> 10
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Ser Val Ser Ser
        115     


<210> 11
<211> 116
<212> PRT
<213> Mus musculus

<400> 11
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Asn Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 12
<211> 116
<212> PRT
<213> Mus musculus

<400> 12
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Ile Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 13
<211> 116
<212> PRT
<213> Mus musculus

<400> 13
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Ile Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Ala Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 14
<211> 116
<212> PRT
<213> Mus musculus

<400> 14
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Asn Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Lys Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 15
<211> 116
<212> PRT
<213> Mus musculus

<400> 15
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Met Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Ile Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 16
<211> 116
<212> PRT
<213> Mus musculus

<400> 16
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Val Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Val Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 17
<211> 116
<212> PRT
<213> Mus musculus

<400> 17
Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Asn Met Asp Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile
        35                  40                  45              
Gly Asp Ile Asp Pro Asn Thr Gly Thr Thr Phe Tyr Asn Gln Asp Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Trp Arg Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Leu
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 18
<211> 120
<212> PRT
<213> Mus musculus

<400> 18
Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Val Lys Ala Leu Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser
        115                 120 


<210> 19
<211> 120
<212> PRT
<213> Mus musculus

<400> 19
Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Glu Ile His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Ser Glu Lys Phe Gly Ser Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Thr Phe Thr Val Ser Ser
        115                 120 


<210> 20
<211> 118
<212> PRT
<213> Mus musculus

<400> 20
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Thr Tyr Ser Gly Ser Pro Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Gln Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Gly His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 21
<211> 118
<212> PRT
<213> Mus musculus

<400> 21
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp
            20                  25                  30          
Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Tyr Ile Thr Tyr Ser Gly Ser Pro Thr Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Gln Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Leu Gly Gly His Tyr Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Thr Leu Thr Val Ser Ser
        115             


<210> 22
<211> 117
<212> PRT
<213> Mus musculus

<400> 22
Glu Val Gln Leu Gln Glu Ser Gly Pro Asp Leu Val Lys Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
Tyr Ser Trp His Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp
        35                  40                  45              
Met Gly Phe Ile His Tyr Ser Gly Asp Thr Asn Tyr Asn Pro Ser Leu
    50                  55                  60                  
Lys Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe
65                  70                  75                  80  
Leu His Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95      
Ala Ser Pro Ser Arg Leu Leu Phe Asp Tyr Trp Gly His Gly Thr Thr
            100                 105                 110         
Leu Thr Val Ser Ser
        115         


<210> 23
<211> 113
<212> PRT
<213> Mus musculus

<400> 23
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val Asp Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Val Gly Ser Thr Asn Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Ser Asp Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 24
<211> 113
<212> PRT
<213> Mus musculus

<400> 24
Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
            20                  25                  30          
Gly Val Asp Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Gly Ile Gly Ser Thr Asn Tyr Asn Ser Ala Leu Lys
    50                  55                  60                  
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ser Asp Asp Thr Ala Met Tyr Tyr Cys Ala
                85                  90                  95      
Ser Asp Gly Phe Val Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
            100                 105                 110         
Ser
    


<210> 25
<211> 114
<212> PRT
<213> Mus musculus

<400> 25
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Met
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Ala Ser Met Ile Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         
Ser Ser
        


<210> 26
<211> 114
<212> PRT
<213> Mus musculus

<400> 26
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Gln Pro Ser Gln
 1               5                  10                  15      
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
            20                  25                  30          
Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Val Ile Trp Arg Gly Gly Asn Thr Asp Tyr Asn Ala Ala Phe Met
    50                  55                  60                  
Ser Arg Leu Ser Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
65                  70                  75                  80  
Lys Phe His Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Ala
                85                  90                  95      
Ala Ser Met Ile Gly Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val
            100                 105                 110         
Ser Ser
        


<210> 27
<211> 108
<212> PRT
<213> Mus musculus

<400> 27
Asp Ile Val Leu Thr Gln Thr Pro Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 28
<211> 108
<212> PRT
<213> Mus musculus

<400> 28
Asp Ile Val Ile Thr Gln Thr Thr Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 29
<211> 108
<212> PRT
<213> Mus musculus

<400> 29
Asp Ile Val Met Thr Gln Thr Pro Ala Thr Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Asn Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Val Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys
            100                 105             


<210> 30
<211> 108
<212> PRT
<213> Mus musculus

<400> 30
Asp Ile Val Met Thr Gln Thr Thr Ala Thr Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Asn Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Val Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys
            100                 105             


<210> 31
<211> 108
<212> PRT
<213> Mus musculus

<400> 31
Asp Ile Val Leu Thr Gln Ser Thr Ala Ile Met Ser Ala Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Gly Val Asn Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu
65                  70                  75                  80  
Ala Glu Asp Ala Ala Ser Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 32
<211> 107
<212> PRT
<213> Mus musculus

<400> 32
Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 33
<211> 107
<212> PRT
<213> Mus musculus

<400> 33
Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 34
<211> 107
<212> PRT
<213> Mus musculus

<400> 34
Asp Ile Val Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 35
<211> 107
<212> PRT
<213> Mus musculus

<400> 35
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Arg Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 36
<211> 107
<212> PRT
<213> Mus musculus

<400> 36
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 37
<211> 107
<212> PRT
<213> Mus musculus

<400> 37
Asp Ile Val Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser His Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 38
<211> 107
<212> PRT
<213> Mus musculus

<400> 38
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser His Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Arg Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 39
<211> 107
<212> PRT
<213> Mus musculus

<400> 39
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 40
<211> 107
<212> PRT
<213> Mus musculus

<400> 40
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Tyr Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Leu Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Glu Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 41
<211> 107
<212> PRT
<213> Mus musculus

<400> 41
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Met Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Tyr Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 42
<211> 107
<212> PRT
<213> Mus musculus

<400> 42
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Gly Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Arg Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Asn Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 43
<211> 107
<212> PRT
<213> Mus musculus

<400> 43
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile
        35                  40                  45              
Tyr Tyr Thr Ser Asn Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asp Leu Ala Pro
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Tyr Leu Pro Trp
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 44
<211> 112
<212> PRT
<213> Mus musculus

<400> 44
Asp Ile Val Ile Thr Gln Ser Pro Leu Ser Leu Pro Val Gly Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser
                85                  90                  95      
Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 45
<211> 112
<212> PRT
<213> Mus musculus

<400> 45
Asp Ile Val Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 46
<211> 112
<212> PRT
<213> Mus musculus

<400> 46
Asp Ile Val Leu Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 47
<211> 112
<212> PRT
<213> Mus musculus

<400> 47
Asp Ile Val Ile Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 48
<211> 112
<212> PRT
<213> Mus musculus

<400> 48
Asp Ile Val Met Thr Gln Ser Thr Leu Ser Leu Pro Val Ser Leu Gly
 1               5                  10                  15      
Asp Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Asn Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 49
<211> 112
<212> PRT
<213> Mus musculus

<400> 49
Asp Ile Val Leu Thr Gln Asp Glu Leu Ser Asn Pro Val Thr Ser Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Val Leu Ile Tyr Phe Met Ser Thr Arg Ala Ser Gly Val Ser
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65                  70                  75                  80  
Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu
                85                  90                  95      
Val Asp Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110         


<210> 50
<211> 112
<212> PRT
<213> Mus musculus

<400> 50
Asp Ile Val Met Thr Gln Asp Glu Leu Tyr Asn Pro Val Thr Ser Gly
 1               5                  10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Lys
            20                  25                  30          
Asp Gly Lys Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Val Leu Ile Tyr Phe Met Ser Thr Arg Ala Ser Gly Val Ser
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Glu Ile
65                  70                  75                  80  
Ser Arg Val Lys Ala Glu Asp Val Gly Val Tyr Tyr Cys Gln Gln Leu
                85                  90                  95      
Val Asp Phe Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 51
<211> 113
<212> PRT
<213> Mus musculus

<400> 51
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Gly Thr Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys
    


<210> 52
<211> 107
<212> PRT
<213> Mus musculus

<400> 52
Asp Ile Val Leu Thr Gln Thr Thr Ala Thr Leu Ser Val Thr Pro Gly
 1               5                  10                  15      
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Val Asn Ser Val Glu Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105         


<210> 53
<211> 107
<212> PRT
<213> Mus musculus

<400> 53
Asp Ile Val Leu Thr Gln Ser Pro Asp Thr Leu Ser Val Thr Pro Gly
 1               5                  10                  15      
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asp Tyr
            20                  25                  30          
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile
        35                  40                  45              
Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro
65                  70                  75                  80  
Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Ser Tyr Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
            100                 105         


<210> 54
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 54
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu
 1               5                  10                  15  


<210> 55
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 55
Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln Leu Gly Trp Arg
 1               5                  10                  15  


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 56
Val Trp Ala Val Leu Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu
 1               5                  10                  15  


<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 57
Gln Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg
 1               5                  10                  15  


<210> 58
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 58
Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro
 1               5                  10                  15  


<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 59
Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala
 1               5                  10                  15  


<210> 60
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 60
Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr
 1               5                  10                  15  


<210> 61
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 61
Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala
 1               5                  10                  15  


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 62
Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser
 1               5                  10                  15  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 63
Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser
 1               5                  10                  15  


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 64
Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu
 1               5                  10                  15  


<210> 65
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 65
Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met
 1               5                  10                  15  


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 66
Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln
 1               5                  10                  15  


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 67
Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala
 1               5                  10                  15  


<210> 68
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 68
Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp
 1               5                  10                  15  


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 69
Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly
 1               5                  10                  15  


<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 70
Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe
 1               5                  10                  15  


<210> 71
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 71
Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu
 1               5                  10                  15  


<210> 72
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 72
Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp
 1               5                  10                  15  


<210> 73
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 73
Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val
 1               5                  10                  15  


<210> 74
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 74
Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg
 1               5                  10                  15  


<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 75
Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr
 1               5                  10                  15  


<210> 76
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 76
Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala
 1               5                  10                  15  


<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 77
Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro
 1               5                  10                  15  


<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 78
Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys
 1               5                  10                  15  


<210> 79
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 79
Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala
 1               5                  10                  15  


<210> 80
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 80
Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr
 1               5                  10                  15  


<210> 81
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 81
Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu
 1               5                  10                  15  


<210> 82
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 82
Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His
 1               5                  10                  15  


<210> 83
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 83
Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro
 1               5                  10                  15  


<210> 84
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> PD-1 peptide sequence

<400> 84
Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe
 1               5                  10                  15      


<210> 85
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-heavy chain variable region

<400> 85
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Asn Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 86
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-heavy chain variable region

<400> 86
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Ser Leu Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Leu Asn Val Asp Lys Ser Thr Asn Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 87
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-heavy chain variable region

<400> 87
Glu Val Gln Leu Val Gln Ser Gly Thr Glu Val Thr Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu
        35                  40                  45              
Gly Met Ile Asp Pro Ser Asn Ser Glu Thr Thr Leu Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Thr Asn Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Thr Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Arg Gly Asn Tyr Ala Tyr Glu Met Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 88
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-heavy chain variable region

<400> 88
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 89
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-heavy chain variable region

<400> 89
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Ile Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 90
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-heavy chain variable region

<400> 90
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met
        35                  40                  45              
Gly Val Ile Asp Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Ser Glu Lys Phe Gly Ser Asn Tyr Tyr Phe Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 91
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-light chain variable region

<400> 91
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 92
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-light chain variable region

<400> 92
Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Thr Gly Ile Pro Ala Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105             


<210> 93
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-light chain variable region

<400> 93
Asp Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Lys Val Thr Leu Ser Cys Arg Ala Ser Ser Ser Val Ser Ser Asn
            20                  25                  30          
Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Val
        35                  40                  45              
Ile Tyr Ser Thr Ser Asn Leu Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Phe Cys His Gln Trp Ser Ser Tyr Pro
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105             


<210> 94
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-light chain variable region

<400> 94
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 95
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-light chain variable region

<400> 95
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 96
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> humanized-light chain variable region

<400> 96
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Ser Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Thr Ile Val His Ser
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln Arg Pro Gly Gln Pro
        35                  40                  45              
Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 97
<211> 143
<212> PRT
<213> Homo sapiens

<400> 97
Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val
 1               5                  10                  15      
Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr
            20                  25                  30          
Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln
        35                  40                  45              
Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln
    50                  55                  60                  
Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His
65                  70                  75                  80  
Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys
                85                  90                  95      
Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg
            100                 105                 110         
Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His
        115                 120                 125             
Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln Thr Val Val
    130                 135                 140             

