                               SEQUENCE LISTING

<110> HELIX BIOPHARMA CORP.
 
<120> ANTIBODY-UREASE CONJUGATES FOR THERAPEUTIC PURPOSES

<130> 105013-1610

<140>
<141>

<150> 62/107,210
<151> 2015-01-23

<160> 9     

<170> PatentIn version 3.5

<210> 1
<211> 122
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 1
Met Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Val Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala His Asp Pro Ile Phe Asp Lys 
            20                  25                  30          


Asn Leu Met Gly Trp Gly Arg Gln Ala Pro Gly Lys Gln Arg Glu Tyr 
        35                  40                  45              


Val Ala Thr Ile Ser Gly Ser Gly Gly Thr Asn Tyr Ala Ser Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Ala Phe Ala Ile Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Glu Glu Asp Asp Gly Lys 
        115                 120         


<210> 2
<211> 840
<212> PRT
<213> Canavalia ensiformis

<400> 2
Met Lys Leu Ser Pro Arg Glu Val Glu Lys Leu Gly Leu His Asn Ala 
1               5                   10                  15      


Gly Tyr Leu Ala Gln Lys Arg Leu Ala Arg Gly Val Arg Leu Asn Tyr 
            20                  25                  30          


Thr Glu Ala Val Ala Leu Ile Ala Ser Gln Ile Met Glu Tyr Ala Arg 
        35                  40                  45              


Asp Gly Glu Lys Thr Val Ala Gln Leu Met Cys Leu Gly Gln His Leu 
    50                  55                  60                  


Leu Gly Arg Arg Gln Val Leu Pro Ala Val Pro His Leu Leu Asn Ala 
65                  70                  75                  80  


Val Gln Val Glu Ala Thr Phe Pro Asp Gly Thr Lys Leu Val Thr Val 
                85                  90                  95      


His Asp Pro Ile Ser Arg Glu Asn Gly Glu Leu Gln Glu Ala Leu Phe 
            100                 105                 110         


Gly Ser Leu Leu Pro Val Pro Ser Leu Asp Lys Phe Ala Glu Thr Lys 
        115                 120                 125             


Glu Asp Asn Arg Ile Pro Gly Glu Ile Leu Cys Glu Asp Glu Cys Leu 
    130                 135                 140                 


Thr Leu Asn Ile Gly Arg Lys Ala Val Ile Leu Lys Val Thr Ser Lys 
145                 150                 155                 160 


Gly Asp Arg Pro Ile Gln Val Gly Ser His Tyr His Phe Ile Glu Val 
                165                 170                 175     


Asn Pro Tyr Leu Thr Phe Asp Arg Arg Lys Ala Tyr Gly Met Arg Leu 
            180                 185                 190         


Asn Ile Ala Ala Gly Thr Ala Val Arg Phe Glu Pro Gly Asp Cys Lys 
        195                 200                 205             


Ser Val Thr Leu Val Ser Ile Glu Gly Asn Lys Val Ile Arg Gly Gly 
    210                 215                 220                 


Asn Ala Ile Ala Asp Gly Pro Val Asn Glu Thr Asn Leu Glu Ala Ala 
225                 230                 235                 240 


Met His Ala Val Arg Ser Lys Gly Phe Gly His Glu Glu Glu Lys Asp 
                245                 250                 255     


Ala Ser Glu Gly Phe Thr Lys Glu Asp Pro Asn Cys Pro Phe Asn Thr 
            260                 265                 270         


Phe Ile His Arg Lys Glu Tyr Ala Asn Lys Tyr Gly Pro Thr Thr Gly 
        275                 280                 285             


Asp Lys Ile Arg Leu Gly Asp Thr Asn Leu Leu Ala Glu Ile Glu Lys 
    290                 295                 300                 


Asp Tyr Ala Leu Tyr Gly Asp Glu Cys Val Phe Gly Gly Gly Lys Val 
305                 310                 315                 320 


Ile Arg Asp Gly Met Gly Gln Ser Cys Gly His Pro Pro Ala Ile Ser 
                325                 330                 335     


Leu Asp Thr Val Ile Thr Asn Ala Val Ile Ile Asp Tyr Thr Gly Ile 
            340                 345                 350         


Ile Lys Ala Asp Ile Gly Ile Lys Asp Gly Leu Ile Ala Ser Ile Gly 
        355                 360                 365             


Lys Ala Gly Asn Pro Asp Ile Met Asn Gly Val Phe Ser Asn Met Ile 
    370                 375                 380                 


Ile Gly Ala Asn Thr Glu Val Ile Ala Gly Glu Gly Leu Ile Val Thr 
385                 390                 395                 400 


Ala Gly Ala Ile Asp Cys His Val His Tyr Ile Cys Pro Gln Leu Val 
                405                 410                 415     


Tyr Glu Ala Ile Ser Ser Gly Ile Thr Thr Leu Val Gly Gly Gly Thr 
            420                 425                 430         


Gly Pro Ala Ala Gly Thr Arg Ala Thr Thr Cys Thr Pro Ser Pro Thr 
        435                 440                 445             


Gln Met Arg Leu Met Leu Gln Ser Thr Asp Asp Leu Pro Leu Asn Phe 
    450                 455                 460                 


Gly Phe Thr Gly Lys Gly Ser Ser Ser Lys Pro Asp Glu Leu His Glu 
465                 470                 475                 480 


Ile Ile Lys Ala Gly Ala Met Gly Leu Lys Leu His Glu Asp Trp Gly 
                485                 490                 495     


Ser Thr Pro Ala Ala Ile Asp Asn Cys Leu Thr Ile Ala Glu His His 
            500                 505                 510         


Asp Ile Gln Ile Asn Ile His Thr Asp Thr Leu Asn Glu Ala Gly Phe 
        515                 520                 525             


Val Glu His Ser Ile Ala Ala Phe Lys Gly Arg Thr Ile His Thr Tyr 
    530                 535                 540                 


His Ser Glu Gly Ala Gly Gly Gly His Ala Pro Asp Ile Ile Lys Val 
545                 550                 555                 560 


Cys Gly Ile Lys Asn Val Leu Pro Ser Ser Thr Asn Pro Thr Arg Pro 
                565                 570                 575     


Leu Thr Ser Asn Thr Ile Asp Glu His Leu Asp Met Leu Met Val Cys 
            580                 585                 590         


His His Leu Asp Arg Glu Ile Pro Glu Asp Leu Ala Phe Ala His Ser 
        595                 600                 605             


Arg Ile Arg Lys Lys Thr Ile Ala Ala Glu Asp Val Leu Asn Asp Ile 
    610                 615                 620                 


Gly Ala Ile Ser Ile Ile Ser Ser Asp Ser Gln Ala Met Gly Arg Val 
625                 630                 635                 640 


Gly Glu Val Ile Ser Arg Thr Trp Gln Thr Ala Asp Lys Met Lys Ala 
                645                 650                 655     


Gln Thr Gly Pro Leu Lys Cys Asp Ser Ser Asp Asn Asp Asn Phe Arg 
            660                 665                 670         


Ile Arg Arg Tyr Ile Ala Lys Tyr Thr Ile Asn Pro Ala Ile Ala Asn 
        675                 680                 685             


Gly Phe Ser Gln Tyr Val Gly Ser Val Glu Val Gly Lys Leu Ala Asp 
    690                 695                 700                 


Leu Val Met Trp Lys Pro Ser Phe Phe Gly Thr Lys Pro Glu Met Val 
705                 710                 715                 720 


Ile Lys Gly Gly Met Val Ala Trp Ala Asp Ile Gly Asp Pro Asn Ala 
                725                 730                 735     


Ser Ile Pro Thr Pro Glu Pro Val Lys Met Arg Pro Met Tyr Gly Thr 
            740                 745                 750         


Leu Gly Lys Ala Gly Gly Ala Leu Ser Ile Ala Phe Val Ser Lys Ala 
        755                 760                 765             


Ala Leu Asp Gln Arg Val Asn Val Leu Tyr Gly Leu Asn Lys Arg Val 
    770                 775                 780                 


Glu Ala Val Ser Asn Val Arg Lys Leu Thr Lys Leu Asp Met Lys Leu 
785                 790                 795                 800 


Asn Asp Ala Leu Pro Glu Ile Thr Val Asp Pro Glu Ser Tyr Thr Val 
                805                 810                 815     


Lys Ala Asp Gly Lys Leu Leu Cys Val Ser Glu Ala Thr Thr Val Pro 
            820                 825                 830         


Leu Ser Arg Asn Tyr Phe Leu Phe 
        835                 840 


<210> 3
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Ile Gln Asn Pro Ala Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asn 
1               5                   10                  15      


Val Leu Tyr Gly Pro Asp Gly Pro Thr Ile Ser Pro Ser Lys Ala Asn 
            20                  25                  30          


Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser Cys His Ala Ala Ser Asn 
        35                  40                  45              


Pro Pro 
    50  


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Glu Ile Gln Asn Pro Ala Ser Ala Asn Arg Ser Asp 
1               5                   10          


<210> 5
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
aaggcgaaag agtggatggc aacagtcta                                         29


<210> 6
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
aagaagcaac cggacagttc catgtatac                                         29


<210> 7
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Leu Ser Cys Ala Ala His Asp Pro Ile Phe Asp Lys Asn Leu Met Gly 
1               5                   10                  15      


Trp Gly Cys 
            


<210> 8
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Leu Ser Cys Ala Ala His Asp Pro Ile Phe Asp Lys Asn Leu Met Gly 
1               5                   10                  15      


Trp Gly Arg 
            


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Cys Asp Ser Ser Asp Asn Asp Asn Phe Arg 
1               5                   10  


