                         SEQUENCE LISTING

<110>  DNX Biotech, LLC
       Datar, Rajiv
       Edwards, Carl  K. III
 
<120>  Compositions and methods for prevention and/or treatment of acute
       and chronic inflammatory and autoimmune diseases using 
       full-length or truncated forms of a soluble TNF-alpha receptor 
       modified for increased half-life

<130>  12998-001

<150>  62/108,825
<151>  2015-01-28

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  1362
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  1

Ala Thr Gly Gly Gly Cys Cys Thr Cys Thr Cys Cys Ala Cys Cys Gly 
1               5                   10                  15      


Thr Gly Cys Cys Thr Gly Ala Cys Cys Thr Gly Cys Thr Gly Cys Thr 
            20                  25                  30          


Gly Cys Cys Gly Cys Thr Gly Gly Thr Gly Cys Thr Cys Cys Thr Gly 
        35                  40                  45              


Gly Ala Gly Cys Thr Gly Thr Thr Gly Gly Thr Gly Gly Gly Ala Ala 
    50                  55                  60                  


Thr Ala Thr Ala Cys Cys Cys Cys Thr Cys Ala Gly Gly Gly Gly Thr 
65                  70                  75                  80  


Thr Ala Thr Thr Gly Gly Ala Cys Thr Gly Gly Thr Cys Cys Cys Thr 
                85                  90                  95      


Cys Ala Cys Cys Thr Ala Gly Gly Gly Gly Ala Cys Ala Gly Gly Gly 
            100                 105                 110         


Ala Gly Ala Ala Gly Ala Gly Ala Gly Ala Thr Ala Gly Thr Gly Thr 
        115                 120                 125             


Gly Thr Gly Thr Cys Cys Cys Cys Ala Ala Gly Gly Ala Ala Ala Ala 
    130                 135                 140                 


Thr Ala Thr Ala Thr Cys Cys Ala Cys Cys Cys Thr Cys Ala Ala Ala 
145                 150                 155                 160 


Ala Thr Ala Ala Thr Thr Cys Gly Ala Thr Thr Thr Gly Cys Thr Gly 
                165                 170                 175     


Thr Ala Cys Cys Ala Ala Gly Thr Gly Cys Cys Ala Cys Ala Ala Ala 
            180                 185                 190         


Gly Gly Ala Ala Cys Cys Thr Ala Cys Thr Thr Gly Thr Ala Cys Ala 
        195                 200                 205             


Ala Thr Gly Ala Cys Thr Gly Thr Cys Cys Ala Gly Gly Cys Cys Cys 
    210                 215                 220                 


Gly Gly Gly Gly Cys Ala Gly Gly Ala Thr Ala Cys Gly Gly Ala Cys 
225                 230                 235                 240 


Thr Gly Cys Ala Gly Gly Gly Ala Gly Thr Gly Thr Gly Ala Gly Ala 
                245                 250                 255     


Gly Cys Gly Gly Cys Thr Cys Cys Thr Thr Cys Ala Cys Cys Gly Cys 
            260                 265                 270         


Thr Thr Cys Ala Gly Ala Ala Ala Ala Cys Cys Ala Cys Cys Thr Cys 
        275                 280                 285             


Ala Gly Ala Cys Ala Cys Thr Gly Cys Cys Thr Cys Ala Gly Cys Thr 
    290                 295                 300                 


Gly Cys Thr Cys Cys Ala Ala Ala Thr Gly Cys Cys Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Gly Ala Ala Ala Thr Gly Gly Gly Thr Cys Ala Gly Gly Thr Gly 
                325                 330                 335     


Gly Ala Gly Ala Thr Cys Thr Cys Thr Thr Cys Thr Thr Gly Cys Ala 
            340                 345                 350         


Cys Ala Gly Thr Gly Gly Ala Cys Cys Gly Gly Gly Ala Cys Ala Cys 
        355                 360                 365             


Cys Gly Thr Gly Thr Gly Thr Gly Gly Cys Thr Gly Cys Ala Gly Gly 
    370                 375                 380                 


Ala Ala Gly Ala Ala Cys Cys Ala Gly Thr Ala Cys Cys Gly Gly Cys 
385                 390                 395                 400 


Ala Thr Thr Ala Thr Thr Gly Gly Ala Gly Thr Gly Ala Ala Ala Ala 
                405                 410                 415     


Cys Cys Thr Thr Thr Thr Cys Cys Ala Gly Thr Gly Cys Thr Thr Cys 
            420                 425                 430         


Ala Ala Thr Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Cys Cys 
        435                 440                 445             


Thr Cys Ala Ala Thr Gly Gly Gly Ala Cys Cys Gly Thr Gly Cys Ala 
    450                 455                 460                 


Cys Cys Thr Cys Thr Cys Cys Thr Gly Cys Cys Ala Gly Gly Ala Gly 
465                 470                 475                 480 


Ala Ala Ala Cys Ala Gly Ala Ala Cys Ala Cys Cys Gly Thr Gly Thr 
                485                 490                 495     


Gly Cys Ala Cys Cys Thr Gly Cys Cys Ala Thr Gly Cys Ala Gly Gly 
            500                 505                 510         


Thr Thr Thr Cys Thr Thr Thr Cys Thr Ala Ala Gly Ala Gly Ala Ala 
        515                 520                 525             


Ala Ala Cys Gly Ala Gly Thr Gly Thr Gly Thr Cys Thr Cys Cys Thr 
    530                 535                 540                 


Gly Thr Ala Gly Thr Ala Ala Cys Thr Gly Thr Ala Ala Gly Ala Ala 
545                 550                 555                 560 


Ala Ala Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Cys Ala Cys Gly 
                565                 570                 575     


Ala Ala Gly Thr Thr Gly Thr Gly Cys Cys Thr Ala Cys Cys Cys Cys 
            580                 585                 590         


Ala Gly Ala Thr Thr Gly Ala Gly Ala Ala Thr Gly Thr Thr Ala Ala 
        595                 600                 605             


Gly Gly Gly Cys Ala Cys Thr Gly Ala Gly Gly Ala Cys Thr Cys Ala 
    610                 615                 620                 


Gly Gly Cys Ala Cys Cys Ala Cys Ala Gly Thr Gly Cys Thr Gly Thr 
625                 630                 635                 640 


Thr Gly Cys Cys Cys Cys Thr Gly Gly Thr Cys Ala Thr Thr Thr Thr 
                645                 650                 655     


Cys Thr Thr Thr Gly Gly Thr Cys Thr Thr Thr Gly Cys Cys Thr Thr 
            660                 665                 670         


Thr Thr Ala Thr Cys Cys Cys Thr Cys Cys Thr Cys Thr Thr Cys Ala 
        675                 680                 685             


Thr Thr Gly Gly Thr Thr Thr Ala Ala Thr Gly Thr Ala Thr Cys Gly 
    690                 695                 700                 


Cys Thr Ala Cys Cys Ala Ala Cys Gly Gly Thr Gly Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Cys Cys Ala Ala Gly Cys Thr Cys Thr Ala Cys Thr Cys Cys Ala 
                725                 730                 735     


Thr Thr Gly Thr Thr Thr Gly Thr Gly Gly Gly Ala Ala Ala Thr Cys 
            740                 745                 750         


Gly Ala Cys Ala Cys Cys Thr Gly Ala Ala Ala Ala Ala Gly Ala Gly 
        755                 760                 765             


Gly Gly Gly Gly Ala Gly Cys Thr Thr Gly Ala Ala Gly Gly Ala Ala 
    770                 775                 780                 


Cys Thr Ala Cys Thr Ala Cys Thr Ala Ala Gly Cys Cys Cys Cys Thr 
785                 790                 795                 800 


Gly Gly Cys Cys Cys Cys Ala Ala Ala Cys Cys Cys Ala Ala Gly Cys 
                805                 810                 815     


Thr Thr Cys Ala Gly Thr Cys Cys Cys Ala Cys Thr Cys Cys Ala Gly 
            820                 825                 830         


Gly Cys Thr Thr Cys Ala Cys Cys Cys Cys Cys Ala Cys Cys Cys Thr 
        835                 840                 845             


Gly Gly Gly Cys Thr Thr Cys Ala Gly Thr Cys Cys Cys Gly Thr Gly 
    850                 855                 860                 


Cys Cys Cys Ala Gly Thr Thr Cys Cys Ala Cys Cys Thr Thr Cys Ala 
865                 870                 875                 880 


Cys Cys Thr Cys Cys Ala Gly Cys Thr Cys Cys Ala Cys Cys Thr Ala 
                885                 890                 895     


Thr Ala Cys Cys Cys Cys Cys Gly Gly Thr Gly Ala Cys Thr Gly Thr 
            900                 905                 910         


Cys Cys Cys Ala Ala Cys Thr Thr Thr Gly Cys Gly Gly Cys Thr Cys 
        915                 920                 925             


Cys Cys Cys Gly Cys Ala Gly Ala Gly Ala Gly Gly Thr Gly Gly Cys 
    930                 935                 940                 


Ala Cys Cys Ala Cys Cys Cys Thr Ala Thr Cys Ala Gly Gly Gly Gly 
945                 950                 955                 960 


Gly Cys Thr Gly Ala Cys Cys Cys Cys Ala Thr Cys Cys Thr Thr Gly 
                965                 970                 975     


Cys Gly Ala Cys Ala Gly Cys Cys Cys Thr Cys Gly Cys Cys Thr Cys 
            980                 985                 990         


Cys Gly Ala Cys Cys Cys Cys Ala  Thr Cys Cys Cys Cys  Ala Ala Cys 
        995                 1000                 1005             


Cys Cys  Cys Cys Thr Thr Cys  Ala Gly Ala Ala Gly  Thr Gly Gly 
    1010                 1015                 1020             


Gly Ala  Gly Gly Ala Cys Ala  Gly Thr Gly Cys Cys  Cys Ala Cys 
    1025                 1030                 1035             


Ala Ala  Gly Cys Cys Ala Cys  Ala Gly Ala Gly Cys  Cys Thr Ala 
    1040                 1045                 1050             


Gly Ala  Cys Ala Cys Thr Gly  Ala Thr Gly Ala Cys  Cys Cys Cys 
    1055                 1060                 1065             


Gly Cys  Gly Ala Cys Gly Cys  Thr Gly Thr Ala Cys  Gly Cys Cys 
    1070                 1075                 1080             


Gly Thr  Gly Gly Thr Gly Gly  Ala Gly Ala Ala Cys  Gly Thr Gly 
    1085                 1090                 1095             


Cys Cys  Cys Cys Cys Gly Thr  Thr Gly Cys Gly Cys  Thr Gly Gly 
    1100                 1105                 1110             


Ala Ala  Gly Gly Ala Ala Thr  Thr Cys Gly Thr Gly  Cys Gly Gly 
    1115                 1120                 1125             


Cys Gly  Cys Cys Thr Ala Gly  Gly Gly Cys Thr Gly  Ala Gly Cys 
    1130                 1135                 1140             


Gly Ala  Cys Cys Ala Cys Gly  Ala Gly Ala Thr Cys  Gly Ala Thr 
    1145                 1150                 1155             


Cys Gly  Gly Cys Thr Gly Gly  Ala Gly Cys Thr Gly  Cys Ala Gly 
    1160                 1165                 1170             


Ala Ala  Cys Gly Gly Gly Cys  Gly Cys Thr Gly Cys  Cys Thr Gly 
    1175                 1180                 1185             


Cys Gly  Cys Gly Ala Gly Gly  Cys Gly Cys Ala Ala  Thr Ala Cys 
    1190                 1195                 1200             


Ala Gly  Cys Ala Thr Gly Cys  Thr Gly Gly Cys Gly  Ala Cys Cys 
    1205                 1210                 1215             


Thr Gly  Gly Ala Gly Gly Cys  Gly Gly Cys Gly Cys  Ala Cys Cys 
    1220                 1225                 1230             


Cys Gly  Gly Cys Gly Cys Gly  Ala Gly Gly Cys Cys  Ala Cys Gly 
    1235                 1240                 1245             


Cys Thr  Gly Gly Ala Gly Cys  Thr Gly Cys Thr Gly  Gly Gly Ala 
    1250                 1255                 1260             


Cys Gly  Cys Gly Thr Gly Cys  Thr Cys Cys Gly Cys  Gly Ala Cys 
    1265                 1270                 1275             


Ala Thr  Gly Gly Ala Cys Cys  Thr Gly Cys Thr Gly  Gly Gly Cys 
    1280                 1285                 1290             


Thr Gly  Cys Thr Thr Gly Gly  Ala Gly Gly Ala Cys  Ala Thr Cys 
    1295                 1300                 1305             


Gly Ala  Gly Gly Ala Gly Gly  Cys Gly Cys Thr Thr  Thr Gly Cys 
    1310                 1315                 1320             


Gly Cys  Cys Cys Cys Gly Cys  Cys Gly Cys Thr Cys  Cys Cys Gly 
    1325                 1330                 1335             


Cys Cys  Cys Gly Cys Gly Cys  Cys Cys Ala Gly Thr  Cys Thr Thr 
    1340                 1345                 1350             


Cys Thr  Cys Ala Gly Ala Thr  Gly Ala 
    1355                 1360         


<210>  2
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  2

Gly Ala Thr Ala Gly Thr Gly Thr Gly Thr Gly Thr Cys Cys Cys Cys 
1               5                   10                  15      


Ala Ala Gly Gly Ala Ala Ala Ala Thr Ala Thr Ala Thr Cys Cys Ala 
            20                  25                  30          


Cys Cys Cys Thr Cys Ala Ala Ala Ala Thr Ala Ala Thr Thr Cys Gly 
        35                  40                  45              


Ala Thr Thr Thr Gly Cys Thr Gly Thr Ala Cys Cys Ala Ala Gly Thr 
    50                  55                  60                  


Gly Cys Cys Ala Cys Ala Ala Ala Gly Gly Ala Ala Cys Cys Thr Ala 
65                  70                  75                  80  


Cys Thr Thr Gly Thr Ala Cys Ala Ala Thr Gly Ala Cys Thr Gly Thr 
                85                  90                  95      


Cys Cys Ala Gly Gly Cys Cys Cys Gly Gly Gly Gly Cys Ala Gly Gly 
            100                 105                 110         


Ala Thr Ala Cys Gly Gly Ala Cys Thr Gly Cys Ala Gly Gly Gly Ala 
        115                 120                 125             


Gly Thr Gly Thr Gly Ala Gly Ala Gly Cys Gly Gly Cys Thr Cys Cys 
    130                 135                 140                 


Thr Thr Cys Ala Cys Cys Gly Cys Thr Thr Cys Ala Gly Ala Ala Ala 
145                 150                 155                 160 


Ala Cys Cys Ala Cys Cys Thr Cys Ala Gly Ala Cys Ala Cys Thr Gly 
                165                 170                 175     


Cys Cys Thr Cys Ala Gly Cys Thr Gly Cys Thr Cys Cys Ala Ala Ala 
            180                 185                 190         


Thr Gly Cys Cys Gly Ala Ala Ala Gly Gly Ala Ala Ala Thr Gly Gly 
        195                 200                 205             


Gly Thr Cys Ala Gly Gly Thr Gly Gly Ala Gly Ala Thr Cys Thr Cys 
    210                 215                 220                 


Thr Thr Cys Thr Thr Gly Cys Ala Cys Ala Gly Thr Gly Gly Ala Cys 
225                 230                 235                 240 


Cys Gly Gly Gly Ala Cys Ala Cys Cys Gly Thr Gly Thr Gly Thr Gly 
                245                 250                 255     


Gly Cys Thr Gly Cys Ala Gly Gly Ala Ala Gly Ala Ala Cys Cys Ala 
            260                 265                 270         


Gly Thr Ala Cys Cys Gly Gly Cys Ala Thr Thr Ala Thr Thr Gly Gly 
        275                 280                 285             


Ala Gly Thr Gly Ala Ala Ala Ala Cys Cys Thr Thr Thr Thr Cys Cys 
    290                 295                 300                 


Ala Gly Thr Gly Cys Thr Thr Cys Ala Ala Thr 
305                 310                 315 


<210>  3
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  3

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Arg Arg Glu Ala Thr 
                405                 410                 415     


Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly Cys 
            420                 425                 430         


Leu Glu Asp Ile Glu Glu Ala Leu Cys Ala Pro Pro Leu Pro Pro Ala 
        435                 440                 445             


Pro Ser Leu Leu Arg 
    450             


<210>  4
<211>  161
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  4

Asp Ser Val Cys Pro Gln Gly Lys Tyr Ile His Pro Gln Asn Asn Ser 
1               5                   10                  15      


Ile Cys Cys Thr Lys Cys His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys 
            20                  25                  30          


Pro Gly Pro Gly Gln Asp Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser 
        35                  40                  45              


Phe Thr Ala Ser Glu Asn His Leu Arg His Cys Leu Ser Cys Ser Lys 
    50                  55                  60                  


Cys Arg Lys Glu Met Gly Gln Val Glu Ile Ser Ser Cys Thr Val Asp 
65                  70                  75                  80  


Arg Asp Thr Val Cys Gly Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp 
                85                  90                  95      


Ser Glu Asn Leu Phe Gln Cys Phe Asn Cys Ser Leu Cys Leu Asn Gly 
            100                 105                 110         


Thr Val His Leu Ser Cys Gln Glu Lys Gln Asn Thr Val Cys Thr Cys 
        115                 120                 125             


His Ala Gly Phe Phe Leu Arg Glu Asn Glu Cys Val Ser Cys Ser Asn 
    130                 135                 140                 


Cys Lys Lys Ser Leu Glu Cys Thr Lys Leu Cys Leu Pro Gln Ile Glu 
145                 150                 155                 160 


Asn 
    


<210>  5
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  5

Asp Ser Val Cys Pro Gln Gly Lys Tyr Ile His Pro Gln Asn Asn Ser 
1               5                   10                  15      


Ile Cys Cys Thr Lys Cys His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys 
            20                  25                  30          


Pro Gly Pro Gly Gln Asp Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser 
        35                  40                  45              


Phe Thr Ala Ser Glu Asn His Leu Arg His Cys Leu Ser Cys Ser Lys 
    50                  55                  60                  


Cys Arg Lys Glu Met Gly Gln Val Glu Ile Ser Ser Cys Thr Val Asp 
65                  70                  75                  80  


Arg Asp Thr Val Cys Gly Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp 
                85                  90                  95      


Ser Glu Asn Leu Phe Gln Cys Phe Asn Cys Ser Leu Cys Leu Asn Gly 
            100                 105                 110         


Thr Val His Leu Ser Cys Gln Glu Lys Gln Asn Thr Val Cys Thr 
        115                 120                 125         


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  6

Asp Ser Val Cys Pro Gln Gly Lys Tyr Ile His Pro Gln Asn Asn Ser 
1               5                   10                  15      


Ile Cys Cys Thr Lys Cys His Lys Gly Thr Tyr Leu Tyr Asn Asp Cys 
            20                  25                  30          


Pro Gly Pro Gly Gln Asp Thr Asp Cys Arg Glu Cys Glu Ser Gly Ser 
        35                  40                  45              


Phe Thr Ala Ser Glu Asn His Leu Arg His Cys Leu Ser Cys Ser Lys 
    50                  55                  60                  


Cys Arg Lys Glu Met Gly Gln Val Glu Ile Ser Ser Cys Thr Val Asp 
65                  70                  75                  80  


Arg Asp Thr Val Cys Gly Cys Arg Lys Asn Gln Tyr Arg His Tyr Trp 
                85                  90                  95      


Ser Glu Asn Leu Phe Gln Cys Phe Asn Cys Ser Leu 
            100                 105             


<210>  7
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  7

Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
1               5                   10                  15      


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
            20                  25                  30          


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
        35                  40                  45              


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
    50                  55                  60                  


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
65                  70                  75                  80  


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
                85                  90                  95      


Asn Cys Ser Leu 
            100 


<210>  8
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  8

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  9
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The sequence was designed and synthesized

<400>  9

Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 
1               5                   10                  15      


Ser Ala Pro Ala 
            20  


