                         SEQUENCE LISTING

<110>  University of Leicester
 
<120>  SENESCENCE

<130>  AXH/75455PCT1

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  1
aactgagtgg ctgtgaaagg gtggggtttg ctcagactgt ccttcctctc tggactgtaa       60

gaatatgtct ccagggccag tgtctgctgc gatcgagtcc caccttccaa gtcctggcat      120

ctcaatgcat ctgggaagct acctgcatta agtcaggact gagcacacag gtgaactcca      180

gaaagaagaa gctatggccg cagtgattct ggagagcatc tttctgaagc gatcccaaca      240

gaaaaagaaa acatcacctc taaacttcaa gaagcgcctg tttctcttga ccgtgcacaa      300

actctcctac tatgagtatg actttgaacg tgggagaaga ggcagtaaga agggttcaat      360

agatgttgag aagatcactt gtgttgaaac agtggttcct gaaaaaaatc ctcctccaga      420

aagacagatt ccgagaagag gtgaagagtc cagtgaaatg gagcaaattt caatcattga      480

aaggttccct tatcccttcc aggttgtata tgatgaaggg cctctctacg tcttctcccc      540

aactgaagaa ctaaggaagc ggtggattca ccagctcaaa aacgtaatcc ggtacaacag      600

tgatctggtt cagaaatatc acccttgctt ctggatcgat gggcagtatc tctgctgctc      660

tcagacagcc aaaaatgcta tgggctgcca aattttggag aacaggaatg gaagcttaaa      720

acctgggagt tctcaccgga agacaaaaaa gcctcttccc ccaacgcctg aggaggacca      780

gatcttgaaa aagccactac cgcctgagcc agcagcagca ccagtctcca caagtgagct      840

gaaaaaggtt gtggcccttt atgattacat gccaatgaat gcaaatgatc tacagctgcg      900

gaagggtgat gaatatttta tcttggagga aagcaactta ccatggtgga gagcacgaga      960

taaaaatggg caggaaggct acattcctag taactatgtc actgaagcag aagactccat     1020

agaaatgtat gagtggtatt ccaaacacat gactcggagt caggctgagc aactgctaaa     1080

gcaagagggg aaagaaggag gtttcattgt cagagactcc agcaaagctg gcaaatatac     1140

agtgtctgtg tttgctaaat ccacagggga ccctcaaggg gtgatacgtc attatgttgt     1200

gtgttccaca cctcagagcc agtattacct ggctgagaag caccttttca gcaccatccc     1260

tgagctcatt aactaccatc agcacaactc tgcaggactc atatccaggc tcaaatatcc     1320

agtgtctcaa caaaacaaga atgcaccttc cactgcaggc ctgggatacg gatcatggga     1380

aattgatcca aaggacctga ccttcttgaa ggagctgggg actggacaat ttggggtagt     1440

gaagtatggg aaatggagag gccagtacga cgtggccatc aagatgatca aagaaggctc     1500

catgtctgaa gatgaattca ttgaagaagc caaagtcatg atgaatcttt cccatgagaa     1560

gctggtgcag ttgtatggcg tctgcaccaa gcagcgcccc atcttcatca tcactgagta     1620

catggccaat ggctgcctcc tgaactacct gagggagatg cgccaccgct tccagactca     1680

gcagctgcta gagatgtgca aggatgtctg tgaagccatg gaatacctgg agtcaaagca     1740

gttccttcac cgagacctgg cagctcgaaa ctgtttggta aacgatcaag gagttgttaa     1800

agtatctgat ttcggcctgt ccaggtatgt cctggatgat gaatacacaa gctcagtagg     1860

ctccaaattt ccagtccggt ggtccccacc ggaagtcctg atgtatagca agttcagcag     1920

caaatctgac atttgggctt ttggggtttt gatgtgggaa atttactccc tggggaagat     1980

gccatatgag agatttacta acagtgagac tgctgaacac attgcccaag gcctacgtct     2040

ctacaggcct catctggctt cagagaaggt atataccatc atgtacagtt gctggcatga     2100

gaaagcagat gagcgtccca ctttcaaaat tcttctgagc aatattctag atgtcatgga     2160

tgaagaatcc tgagctcgcc aataagcttc ttggttctac ttctcttctc cacaagcccc     2220

aatttcactt tctcagagga aatcccaagc ttaggagccc tggagccttt gtgctcccac     2280

tcaatacaaa aaggcccctc tctacatctg ggaatgcacc tcttctttga ttccctggga     2340

tagtggcttc tgagcaaagg ccaagaaatt attgtgcctg aaatttcccg agagaattaa     2400

gacagactga atttgcgatg aaaatatttt ttaggaggga ggatgtaaat agccgcacaa     2460

aggggtccaa cagctctttg agtaggcatt tggtagagct tgggggtgtg tgtgtggggg     2520

tggaccgaat ttggcaagaa tgaaatggtg tcataaagat gggaggggag ggtgttttga     2580

taaaataaaa ttactagaaa gcttgaaagt c                                    2611


<210>  2
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Val Ile Leu Glu Ser Ile Phe Leu Lys Arg Ser Gln Gln 
1               5                   10                  15      


Lys Lys Lys Thr Ser Pro Leu Asn Phe Lys Lys Arg Leu Phe Leu Leu 
            20                  25                  30          


Thr Val His Lys Leu Ser Tyr Tyr Glu Tyr Asp Phe Glu Arg Gly Arg 
        35                  40                  45              


Arg Gly Ser Lys Lys Gly Ser Ile Asp Val Glu Lys Ile Thr Cys Val 
    50                  55                  60                  


Glu Thr Val Val Pro Glu Lys Asn Pro Pro Pro Glu Arg Gln Ile Pro 
65                  70                  75                  80  


Arg Arg Gly Glu Glu Ser Ser Glu Met Glu Gln Ile Ser Ile Ile Glu 
                85                  90                  95      


Arg Phe Pro Tyr Pro Phe Gln Val Val Tyr Asp Glu Gly Pro Leu Tyr 
            100                 105                 110         


Val Phe Ser Pro Thr Glu Glu Leu Arg Lys Arg Trp Ile His Gln Leu 
        115                 120                 125             


Lys Asn Val Ile Arg Tyr Asn Ser Asp Leu Val Gln Lys Tyr His Pro 
    130                 135                 140                 


Cys Phe Trp Ile Asp Gly Gln Tyr Leu Cys Cys Ser Gln Thr Ala Lys 
145                 150                 155                 160 


Asn Ala Met Gly Cys Gln Ile Leu Glu Asn Arg Asn Gly Ser Leu Lys 
                165                 170                 175     


Pro Gly Ser Ser His Arg Lys Thr Lys Lys Pro Leu Pro Pro Thr Pro 
            180                 185                 190         


Glu Glu Asp Gln Ile Leu Lys Lys Pro Leu Pro Pro Glu Pro Ala Ala 
        195                 200                 205             


Ala Pro Val Ser Thr Ser Glu Leu Lys Lys Val Val Ala Leu Tyr Asp 
    210                 215                 220                 


Tyr Met Pro Met Asn Ala Asn Asp Leu Gln Leu Arg Lys Gly Asp Glu 
225                 230                 235                 240 


Tyr Phe Ile Leu Glu Glu Ser Asn Leu Pro Trp Trp Arg Ala Arg Asp 
                245                 250                 255     


Lys Asn Gly Gln Glu Gly Tyr Ile Pro Ser Asn Tyr Val Thr Glu Ala 
            260                 265                 270         


Glu Asp Ser Ile Glu Met Tyr Glu Trp Tyr Ser Lys His Met Thr Arg 
        275                 280                 285             


Ser Gln Ala Glu Gln Leu Leu Lys Gln Glu Gly Lys Glu Gly Gly Phe 
    290                 295                 300                 


Ile Val Arg Asp Ser Ser Lys Ala Gly Lys Tyr Thr Val Ser Val Phe 
305                 310                 315                 320 


Ala Lys Ser Thr Gly Asp Pro Gln Gly Val Ile Arg His Tyr Val Val 
                325                 330                 335     


Cys Ser Thr Pro Gln Ser Gln Tyr Tyr Leu Ala Glu Lys His Leu Phe 
            340                 345                 350         


Ser Thr Ile Pro Glu Leu Ile Asn Tyr His Gln His Asn Ser Ala Gly 
        355                 360                 365             


Leu Ile Ser Arg Leu Lys Tyr Pro Val Ser Gln Gln Asn Lys Asn Ala 
    370                 375                 380                 


Pro Ser Thr Ala Gly Leu Gly Tyr Gly Ser Trp Glu Ile Asp Pro Lys 
385                 390                 395                 400 


Asp Leu Thr Phe Leu Lys Glu Leu Gly Thr Gly Gln Phe Gly Val Val 
                405                 410                 415     


Lys Tyr Gly Lys Trp Arg Gly Gln Tyr Asp Val Ala Ile Lys Met Ile 
            420                 425                 430         


Lys Glu Gly Ser Met Ser Glu Asp Glu Phe Ile Glu Glu Ala Lys Val 
        435                 440                 445             


Met Met Asn Leu Ser His Glu Lys Leu Val Gln Leu Tyr Gly Val Cys 
    450                 455                 460                 


Thr Lys Gln Arg Pro Ile Phe Ile Ile Thr Glu Tyr Met Ala Asn Gly 
465                 470                 475                 480 


Cys Leu Leu Asn Tyr Leu Arg Glu Met Arg His Arg Phe Gln Thr Gln 
                485                 490                 495     


Gln Leu Leu Glu Met Cys Lys Asp Val Cys Glu Ala Met Glu Tyr Leu 
            500                 505                 510         


Glu Ser Lys Gln Phe Leu His Arg Asp Leu Ala Ala Arg Asn Cys Leu 
        515                 520                 525             


Val Asn Asp Gln Gly Val Val Lys Val Ser Asp Phe Gly Leu Ser Arg 
    530                 535                 540                 


Tyr Val Leu Asp Asp Glu Tyr Thr Ser Ser Val Gly Ser Lys Phe Pro 
545                 550                 555                 560 


Val Arg Trp Ser Pro Pro Glu Val Leu Met Tyr Ser Lys Phe Ser Ser 
                565                 570                 575     


Lys Ser Asp Ile Trp Ala Phe Gly Val Leu Met Trp Glu Ile Tyr Ser 
            580                 585                 590         


Leu Gly Lys Met Pro Tyr Glu Arg Phe Thr Asn Ser Glu Thr Ala Glu 
        595                 600                 605             


His Ile Ala Gln Gly Leu Arg Leu Tyr Arg Pro His Leu Ala Ser Glu 
    610                 615                 620                 


Lys Val Tyr Thr Ile Met Tyr Ser Cys Trp His Glu Lys Ala Asp Glu 
625                 630                 635                 640 


Arg Pro Thr Phe Lys Ile Leu Leu Ser Asn Ile Leu Asp Val Met Asp 
                645                 650                 655     


Glu Glu Ser 
            


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Btk siRNA-1 (accession no. NM_000061 and L29788); targeted region
       (cDNA)

<400>  3
ttggtaaacg atcaaggag                                                    19


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Btk sense siRNA

<400>  4
uugguaaacg aucaaggagu u                                                 21


<210>  5
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Btk antisense siRNA

<400>  5
uuaaccauuu gcuaguuccu c                                                 21


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Btk siRNA-2; targeted region (cDNA)

<400>  6
gggaaagaag gaggtttca                                                    19


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Btk sense siRNA-2

<400>  7
gggaaagaag gagguuucau u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Btk antisense siRNA-2

<400>  8
uucccuuucu uccuccaaag u                                                 21


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Btk siRNA-3; targeted region (cDNA)

<400>  9
gaagcttaaa acctgggag                                                    19


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  BTk sense siRNA-3

<400>  10
gaagcuuaaa accugggagu u                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Btk antisense siRNA-3

<400>  11
uucuucgaau uuuccacccu c                                                 21


