                         SEQUENCE LISTING

<110>  Singapore Health Services Pte Ltd
 
<120>  Identification of novel single polymorphisms in KCNH2 gene and 
       uses thereof

<130>  FP7933

<150>  SG 10201501047U
<151>  2015-02-11

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1159
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Lys Asn Asp Ile Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly 
                805                 810                 815     


Lys Ser Asn Gly Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys 
            820                 825                 830         


Ile His Arg Asp Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe 
        835                 840                 845             


Ser Asp His Phe Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp 
    850                 855                 860                 


Thr Asn Met Ile Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly 
865                 870                 875                 880 


Phe Ser Arg Gln Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp 
                885                 890                 895     


Lys Asp Thr Glu Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg 
            900                 905                 910         


Ala Gly Ala Gly Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly 
        915                 920                 925             


Glu Ser Pro Ser Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu 
    930                 935                 940                 


Gly Pro Gly Arg Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser 
945                 950                 955                 960 


Pro Arg Pro Pro Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp 
                965                 970                 975     


Cys Glu Lys Ser Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser 
            980                 985                 990         


Gly Val Ser Asn Ile Phe Ser Phe  Trp Gly Asp Ser Arg  Gly Arg Gln 
        995                 1000                 1005             


Tyr Gln  Glu Leu Pro Arg Cys  Pro Ala Pro Thr Pro  Ser Leu Leu 
    1010                 1015                 1020             


Asn Ile  Pro Leu Ser Ser Pro  Gly Arg Arg Pro Arg  Gly Asp Val 
    1025                 1030                 1035             


Glu Ser  Arg Leu Asp Ala Leu  Gln Arg Gln Leu Asn  Arg Leu Glu 
    1040                 1045                 1050             


Thr Arg  Leu Ser Ala Asp Met  Ala Thr Val Leu Gln  Leu Leu Gln 
    1055                 1060                 1065             


Arg Gln  Met Thr Leu Val Pro  Pro Ala Tyr Ser Ala  Val Thr Thr 
    1070                 1075                 1080             


Pro Gly  Pro Gly Pro Thr Ser  Thr Ser Pro Leu Leu  Pro Val Ser 
    1085                 1090                 1095             


Pro Leu  Pro Thr Leu Thr Leu  Asp Ser Leu Ser Gln  Val Ser Gln 
    1100                 1105                 1110             


Phe Met  Ala Cys Glu Glu Leu  Pro Pro Gly Ala Pro  Glu Leu Pro 
    1115                 1120                 1125             


Gln Glu  Gly Pro Thr Arg Arg  Leu Ser Leu Pro Gly  Gln Leu Gly 
    1130                 1135                 1140             


Ala Leu  Thr Ser Gln Pro Leu  His Arg His Gly Ser  Asp Pro Gly 
    1145                 1150                 1155             


Ser 
    


<210>  2
<211>  888
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Val Arg Arg Gly His Val Ala Pro Gln Asn Thr Phe Leu Asp 
1               5                   10                  15      


Thr Ile Ile Arg Lys Phe Glu Gly Gln Ser Arg Lys Phe Ile Ile Ala 
            20                  25                  30          


Asn Ala Arg Val Glu Asn Cys Ala Val Ile Tyr Cys Asn Asp Gly Phe 
        35                  40                  45              


Cys Glu Leu Cys Gly Tyr Ser Arg Ala Glu Val Met Gln Arg Pro Cys 
    50                  55                  60                  


Thr Cys Asp Phe Leu His Gly Pro Arg Thr Gln Arg Arg Ala Ala Ala 
65                  70                  75                  80  


Gln Ile Ala Gln Ala Leu Leu Gly Ala Glu Glu Arg Lys Val Glu Ile 
                85                  90                  95      


Ala Phe Tyr Arg Lys Asp Gly Ser Cys Phe Leu Cys Leu Val Asp Val 
            100                 105                 110         


Val Pro Val Lys Asn Glu Asp Gly Ala Val Ile Met Phe Ile Leu Asn 
        115                 120                 125             


Phe Glu Val Val Met Glu Lys Asp Met Val Gly Ser Pro Ala His Asp 
    130                 135                 140                 


Thr Asn His Arg Gly Pro Pro Thr Ser Trp Leu Ala Pro Gly Arg Ala 
145                 150                 155                 160 


Lys Thr Phe Arg Leu Lys Leu Pro Ala Leu Leu Ala Leu Thr Ala Arg 
                165                 170                 175     


Glu Ser Ser Val Arg Ser Gly Gly Ala Gly Gly Ala Gly Ala Pro Gly 
            180                 185                 190         


Ala Val Val Val Asp Val Asp Leu Thr Pro Ala Ala Pro Ser Ser Glu 
        195                 200                 205             


Ser Leu Ala Leu Asp Glu Val Thr Ala Met Asp Asn His Val Ala Gly 
    210                 215                 220                 


Leu Gly Pro Ala Glu Glu Arg Arg Ala Leu Val Gly Pro Gly Ser Pro 
225                 230                 235                 240 


Pro Arg Ser Ala Pro Gly Gln Leu Pro Ser Pro Arg Ala His Ser Leu 
                245                 250                 255     


Asn Pro Asp Ala Ser Gly Ser Ser Cys Ser Leu Ala Arg Thr Arg Ser 
            260                 265                 270         


Arg Glu Ser Cys Ala Ser Val Arg Arg Ala Ser Ser Ala Asp Asp Ile 
        275                 280                 285             


Glu Ala Met Arg Ala Gly Val Leu Pro Pro Pro Pro Arg His Ala Ser 
    290                 295                 300                 


Thr Gly Ala Met His Pro Leu Arg Ser Gly Leu Leu Asn Ser Thr Ser 
305                 310                 315                 320 


Asp Ser Asp Leu Val Arg Tyr Arg Thr Ile Ser Lys Ile Pro Gln Ile 
                325                 330                 335     


Thr Leu Asn Phe Val Asp Leu Lys Gly Asp Pro Phe Leu Ala Ser Pro 
            340                 345                 350         


Thr Ser Asp Arg Glu Ile Ile Ala Pro Lys Ile Lys Glu Arg Thr His 
        355                 360                 365             


Asn Val Thr Glu Lys Val Thr Gln Val Leu Ser Leu Gly Ala Asp Val 
    370                 375                 380                 


Leu Pro Glu Tyr Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile 
385                 390                 395                 400 


Leu His Tyr Ser Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu 
                405                 410                 415     


Leu Val Ile Tyr Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu 
            420                 425                 430         


Leu Lys Glu Thr Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala 
        435                 440                 445             


Cys Gln Pro Leu Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile 
    450                 455                 460                 


Val Asp Ile Leu Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu 
465                 470                 475                 480 


Glu Val Val Ser His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly 
                485                 490                 495     


Trp Phe Leu Ile Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile 
            500                 505                 510         


Phe Gly Ser Gly Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg 
        515                 520                 525             


Leu Leu Arg Leu Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu 
    530                 535                 540                 


Tyr Gly Ala Ala Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile 
545                 550                 555                 560 


Ala His Trp Leu Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln 
                565                 570                 575     


Pro His Met Asp Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln 
            580                 585                 590         


Ile Gly Lys Pro Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys 
        595                 600                 605             


Asp Lys Tyr Val Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser 
    610                 615                 620                 


Val Gly Phe Gly Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe 
625                 630                 635                 640 


Ser Ile Cys Val Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe 
                645                 650                 655     


Gly Asn Val Ser Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg 
            660                 665                 670         


Tyr His Thr Gln Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln 
        675                 680                 685             


Ile Pro Asn Pro Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala 
    690                 695                 700                 


Trp Ser Tyr Thr Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe 
705                 710                 715                 720 


Pro Glu Cys Leu Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu 
                725                 730                 735     


Leu Gln His Cys Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg 
            740                 745                 750         


Ala Leu Ala Met Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr 
        755                 760                 765             


Leu Val His Ala Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg 
    770                 775                 780                 


Gly Ser Ile Glu Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly 
785                 790                 795                 800 


Met Gly Trp Gly Ala Gly Thr Gly Leu Glu Met Pro Ser Ala Ala Ser 
                805                 810                 815     


Arg Gly Ala Ser Leu Leu Asn Met Gln Ser Leu Gly Leu Trp Thr Trp 
            820                 825                 830         


Asp Cys Leu Gln Gly His Trp Ala Pro Leu Ile His Leu Asn Ser Gly 
        835                 840                 845             


Pro Pro Ser Gly Ala Met Glu Arg Ser Pro Thr Trp Gly Glu Ala Ala 
    850                 855                 860                 


Glu Leu Trp Gly Ser His Ile Leu Leu Pro Phe Arg Ile Arg His Lys 
865                 870                 875                 880 


Gln Thr Leu Phe Ala Ser Leu Lys 
                885             


<210>  3
<211>  819
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Ala Pro Ala Gly Lys Ala Ser Arg Thr Gly Ala Leu Arg Pro 
1               5                   10                  15      


Arg Ala Gln Lys Gly Arg Val Arg Arg Ala Val Arg Ile Ser Ser Leu 
            20                  25                  30          


Val Ala Gln Glu Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr 
        35                  40                  45              


Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser 
    50                  55                  60                  


Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr 
65                  70                  75                  80  


Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Lys Glu Thr 
                85                  90                  95      


Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala Cys Gln Pro Leu 
            100                 105                 110         


Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Val Asp Ile Leu 
        115                 120                 125             


Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu Glu Val Val Ser 
    130                 135                 140                 


His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile 
145                 150                 155                 160 


Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly 
                165                 170                 175     


Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu 
            180                 185                 190         


Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala 
        195                 200                 205             


Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu 
    210                 215                 220                 


Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln Pro His Met Asp 
225                 230                 235                 240 


Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln Ile Gly Lys Pro 
                245                 250                 255     


Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys Asp Lys Tyr Val 
            260                 265                 270         


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
        275                 280                 285             


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe Ser Ile Cys Val 
    290                 295                 300                 


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
305                 310                 315                 320 


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln 
                325                 330                 335     


Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
            340                 345                 350         


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr 
        355                 360                 365             


Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu 
    370                 375                 380                 


Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu Leu Gln His Cys 
385                 390                 395                 400 


Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg Ala Leu Ala Met 
                405                 410                 415     


Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Ala 
            420                 425                 430         


Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu 
        435                 440                 445             


Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly Lys Asn Asp Ile 
    450                 455                 460                 


Phe Gly Glu Pro Leu Asn Leu Tyr Ala Arg Pro Gly Lys Ser Asn Gly 
465                 470                 475                 480 


Asp Val Arg Ala Leu Thr Tyr Cys Asp Leu His Lys Ile His Arg Asp 
                485                 490                 495     


Asp Leu Leu Glu Val Leu Asp Met Tyr Pro Glu Phe Ser Asp His Phe 
            500                 505                 510         


Trp Ser Ser Leu Glu Ile Thr Phe Asn Leu Arg Asp Thr Asn Met Ile 
        515                 520                 525             


Pro Gly Ser Pro Gly Ser Thr Glu Leu Glu Gly Gly Phe Ser Arg Gln 
    530                 535                 540                 


Arg Lys Arg Lys Leu Ser Phe Arg Arg Arg Thr Asp Lys Asp Thr Glu 
545                 550                 555                 560 


Gln Pro Gly Glu Val Ser Ala Leu Gly Pro Gly Arg Ala Gly Ala Gly 
                565                 570                 575     


Pro Ser Ser Arg Gly Arg Pro Gly Gly Pro Trp Gly Glu Ser Pro Ser 
            580                 585                 590         


Ser Gly Pro Ser Ser Pro Glu Ser Ser Glu Asp Glu Gly Pro Gly Arg 
        595                 600                 605             


Ser Ser Ser Pro Leu Arg Leu Val Pro Phe Ser Ser Pro Arg Pro Pro 
    610                 615                 620                 


Gly Glu Pro Pro Gly Gly Glu Pro Leu Met Glu Asp Cys Glu Lys Ser 
625                 630                 635                 640 


Ser Asp Thr Cys Asn Pro Leu Ser Gly Ala Phe Ser Gly Val Ser Asn 
                645                 650                 655     


Ile Phe Ser Phe Trp Gly Asp Ser Arg Gly Arg Gln Tyr Gln Glu Leu 
            660                 665                 670         


Pro Arg Cys Pro Ala Pro Thr Pro Ser Leu Leu Asn Ile Pro Leu Ser 
        675                 680                 685             


Ser Pro Gly Arg Arg Pro Arg Gly Asp Val Glu Ser Arg Leu Asp Ala 
    690                 695                 700                 


Leu Gln Arg Gln Leu Asn Arg Leu Glu Thr Arg Leu Ser Ala Asp Met 
705                 710                 715                 720 


Ala Thr Val Leu Gln Leu Leu Gln Arg Gln Met Thr Leu Val Pro Pro 
                725                 730                 735     


Ala Tyr Ser Ala Val Thr Thr Pro Gly Pro Gly Pro Thr Ser Thr Ser 
            740                 745                 750         


Pro Leu Leu Pro Val Ser Pro Leu Pro Thr Leu Thr Leu Asp Ser Leu 
        755                 760                 765             


Ser Gln Val Ser Gln Phe Met Ala Cys Glu Glu Leu Pro Pro Gly Ala 
    770                 775                 780                 


Pro Glu Leu Pro Gln Glu Gly Pro Thr Arg Arg Leu Ser Leu Pro Gly 
785                 790                 795                 800 


Gln Leu Gly Ala Leu Thr Ser Gln Pro Leu His Arg His Gly Ser Asp 
                805                 810                 815     


Pro Gly Ser 
            


<210>  4
<211>  548
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Pro Ala Gly Lys Ala Ser Arg Thr Gly Ala Leu Arg Pro 
1               5                   10                  15      


Arg Ala Gln Lys Gly Arg Val Arg Arg Ala Val Arg Ile Ser Ser Leu 
            20                  25                  30          


Val Ala Gln Glu Val Leu Ser Leu Gly Ala Asp Val Leu Pro Glu Tyr 
        35                  40                  45              


Lys Leu Gln Ala Pro Arg Ile His Arg Trp Thr Ile Leu His Tyr Ser 
    50                  55                  60                  


Pro Phe Lys Ala Val Trp Asp Trp Leu Ile Leu Leu Leu Val Ile Tyr 
65                  70                  75                  80  


Thr Ala Val Phe Thr Pro Tyr Ser Ala Ala Phe Leu Leu Lys Glu Thr 
                85                  90                  95      


Glu Glu Gly Pro Pro Ala Thr Glu Cys Gly Tyr Ala Cys Gln Pro Leu 
            100                 105                 110         


Ala Val Val Asp Leu Ile Val Asp Ile Met Phe Ile Val Asp Ile Leu 
        115                 120                 125             


Ile Asn Phe Arg Thr Thr Tyr Val Asn Ala Asn Glu Glu Val Val Ser 
    130                 135                 140                 


His Pro Gly Arg Ile Ala Val His Tyr Phe Lys Gly Trp Phe Leu Ile 
145                 150                 155                 160 


Asp Met Val Ala Ala Ile Pro Phe Asp Leu Leu Ile Phe Gly Ser Gly 
                165                 170                 175     


Ser Glu Glu Leu Ile Gly Leu Leu Lys Thr Ala Arg Leu Leu Arg Leu 
            180                 185                 190         


Val Arg Val Ala Arg Lys Leu Asp Arg Tyr Ser Glu Tyr Gly Ala Ala 
        195                 200                 205             


Val Leu Phe Leu Leu Met Cys Thr Phe Ala Leu Ile Ala His Trp Leu 
    210                 215                 220                 


Ala Cys Ile Trp Tyr Ala Ile Gly Asn Met Glu Gln Pro His Met Asp 
225                 230                 235                 240 


Ser Arg Ile Gly Trp Leu His Asn Leu Gly Asp Gln Ile Gly Lys Pro 
                245                 250                 255     


Tyr Asn Ser Ser Gly Leu Gly Gly Pro Ser Ile Lys Asp Lys Tyr Val 
            260                 265                 270         


Thr Ala Leu Tyr Phe Thr Phe Ser Ser Leu Thr Ser Val Gly Phe Gly 
        275                 280                 285             


Asn Val Ser Pro Asn Thr Asn Ser Glu Lys Ile Phe Ser Ile Cys Val 
    290                 295                 300                 


Met Leu Ile Gly Ser Leu Met Tyr Ala Ser Ile Phe Gly Asn Val Ser 
305                 310                 315                 320 


Ala Ile Ile Gln Arg Leu Tyr Ser Gly Thr Ala Arg Tyr His Thr Gln 
                325                 330                 335     


Met Leu Arg Val Arg Glu Phe Ile Arg Phe His Gln Ile Pro Asn Pro 
            340                 345                 350         


Leu Arg Gln Arg Leu Glu Glu Tyr Phe Gln His Ala Trp Ser Tyr Thr 
        355                 360                 365             


Asn Gly Ile Asp Met Asn Ala Val Leu Lys Gly Phe Pro Glu Cys Leu 
    370                 375                 380                 


Gln Ala Asp Ile Cys Leu His Leu Asn Arg Ser Leu Leu Gln His Cys 
385                 390                 395                 400 


Lys Pro Phe Arg Gly Ala Thr Lys Gly Cys Leu Arg Ala Leu Ala Met 
                405                 410                 415     


Lys Phe Lys Thr Thr His Ala Pro Pro Gly Asp Thr Leu Val His Ala 
            420                 425                 430         


Gly Asp Leu Leu Thr Ala Leu Tyr Phe Ile Ser Arg Gly Ser Ile Glu 
        435                 440                 445             


Ile Leu Arg Gly Asp Val Val Val Ala Ile Leu Gly Met Gly Trp Gly 
    450                 455                 460                 


Ala Gly Thr Gly Leu Glu Met Pro Ser Ala Ala Ser Arg Gly Ala Ser 
465                 470                 475                 480 


Leu Leu Asn Met Gln Ser Leu Gly Leu Trp Thr Trp Asp Cys Leu Gln 
                485                 490                 495     


Gly His Trp Ala Pro Leu Ile His Leu Asn Ser Gly Pro Pro Ser Gly 
            500                 505                 510         


Ala Met Glu Arg Ser Pro Thr Trp Gly Glu Ala Ala Glu Leu Trp Gly 
        515                 520                 525             


Ser His Ile Leu Leu Pro Phe Arg Ile Arg His Lys Gln Thr Leu Phe 
    530                 535                 540                 


Ala Ser Leu Lys 
545             


<210>  5
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  SNP 1.1 FP

<400>  5
accttcctgg acaccatcat ccg                                               23


<210>  6
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 1.1 RP

<400>  6
ggaattaggt gacagtctcc agggc                                             25


<210>  7
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 1.2 FP

<400>  7
cgggctgatc ttgtatcttg caacc                                             25


<210>  8
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  SNP 1.2 RP

<400>  8
aaggtgcaca cagctgccac tgtc                                              24


<210>  9
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  SNP 2.1 FP

<400>  9
accttcctgg acaccatcat ccg                                               23


<210>  10
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 2.1 RP

<400>  10
ggaattaggt gacagtctcc agggc                                             25


<210>  11
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SNP 2.2 FP

<400>  11
tgggacttcc agttcgtgca cc                                                22


<210>  12
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SNP 2.2 RP

<400>  12
gaaaggccag ggacattgca gg                                                22


<210>  13
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SNP 5.2 FP

<400>  13
actgcaacag ctgatgctgc gg                                                22


<210>  14
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 5.2 RP

<400>  14
atcgctctgg tctgcctcct atctc                                             25


<210>  15
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SNP 6.2 FP

<400>  15
ccgcatatct tggccactct cg                                                22


<210>  16
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  SNP 6.2 RP

<400>  16
ccctacttga caccacatac gggg                                              24


<210>  17
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 1 FP

<400>  17
agtttgatgg tggccttggg ctctg                                             25


<210>  18
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 1 RP

<400>  18
atggagggga ctttagggga gcacc                                             25


<210>  19
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 2 FP

<400>  19
accttcccag gcttctcagc aggag                                             25


<210>  20
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 2 RP

<400>  20
acagggagag agtgtgtgtg tgcgc                                             25


<210>  21
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 3 FP

<400>  21
aactgagtgc ttggcctaaa agggg                                             25


<210>  22
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 3 RP

<400>  22
ccactcagtg ggcagagcag aaagc                                             25


<210>  23
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 4 FP

<400>  23
aactgagtgc ttggcctaaa agggg                                             25


<210>  24
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 4 RP

<400>  24
ccactcagtg ggcagagcag aaagc                                             25


<210>  25
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SNP 5 FP

<400>  25
ggtgcctggg agatggaaat cc                                                22


<210>  26
<211>  22
<212>  DNA
<213>  artificial

<220>
<223>  SNP 5 RP

<400>  26
tccgaggtgg agttgagcaa gc                                                22


<210>  27
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 6 FP

<400>  27
ctggaatgtg cggaagccac tgtgt                                             25


<210>  28
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 6 RP

<400>  28
ctctgcagcc accagctcac ctatg                                             25


<210>  29
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 7 FP

<400>  29
ctgctgaagg agacggaaga aggcc                                             25


<210>  30
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 7 RP

<400>  30
agttggtgtt gggagagacg ttgcc                                             25


<210>  31
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 8 FP

<400>  31
ctgctgaagg agacggaaga aggcc                                             25


<210>  32
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 8 RP

<400>  32
agttggtgtt gggagagacg ttgcc                                             25


<210>  33
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 9 FP

<400>  33
ctgctgaagg agacggaaga aggcc                                             25


<210>  34
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 9 RP

<400>  34
agttggtgtt gggagagacg ttgcc                                             25


<210>  35
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 10 FP

<400>  35
tagagactcc aggggccacc atcgt                                             25


<210>  36
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 10 RP

<400>  36
gtttgctgtg ccaagaggtt cccct                                             25


<210>  37
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 11 FP

<400>  37
tctacttccc accttggtgc ctccc                                             25


<210>  38
<211>  25
<212>  DNA
<213>  artificial

<220>
<223>  SNP 11 RP

<400>  38
agttcctctc cccttccacg gtcag                                             25


