                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
 
<120>  Non Membrane Disruptive p53 Activating Stapled Peptides

<130>  9869SG3615

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-01; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<400>  1

Thr Ser Phe Xaa Glu Tyr Trp Xaa Leu Leu Pro Glu Asn Phe 
1               5                   10                  


<210>  2
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-02; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<400>  2

Thr Ser Phe Xaa Glu Tyr Trp Xaa Leu Leu Pro Glu Asn Tyr 
1               5                   10                  


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-03; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  3

Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu Asn Phe 
1               5                   10                  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-04; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  4

Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu Asn Tyr 
1               5                   10                  


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-05; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Thr Ser Phe Xaa Glu Tyr Trp Xaa Leu Leu Xaa Glu Asn Phe 
1               5                   10                  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-06; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Thr Ser Phe Xaa Glu Tyr Trp Xaa Leu Leu Xaa Glu Asn Tyr 
1               5                   10                  


<210>  7
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  YS-07; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is aminohexanoic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  7

Lys Lys Xaa Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu Asn 
1               5                   10                  15      


Phe 
    


<210>  8
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  YS-08; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is aminohexanoic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  8

Lys Lys Xaa Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu Asn 
1               5                   10                  15      


Tyr 
    


<210>  9
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  YS-08; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aminohexanoic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  9

Arg Arg Arg Xaa Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu 
1               5                   10                  15      


Asn Phe 
        


<210>  10
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  YS-10; capped, meaning acetylated N-terminus, NH2 at C-terminus.


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aminohexanoic acid

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is is (S)-2-(4'-pentenyl)alanine

<400>  10

Arg Arg Arg Xaa Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu 
1               5                   10                  15      


Asn Tyr 
        


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  YS-11 (SAH-p53-8)


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  11

Gln Thr Phe Xaa Asn Leu Trp Arg Leu Leu Xaa Gln Asn 
1               5                   10              


<210>  12
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  p53 WT

<400>  12

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10              


<210>  13
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  p53 WT-1

<400>  13

Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10                  


<210>  14
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  p53-WT (capped; meaning acetylated N-terminus, NH2 at C-terminus)

<400>  14

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
1               5                   10              


<210>  15
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Extended p53-a

<400>  15

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Phe 
1               5                   10                  


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Extended p53-b

<400>  16

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Tyr 
1               5                   10                  


<210>  17
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Extended p53-c

<400>  17

Thr Ser Phe Ser Glu Tyr Trp Lys Leu Leu Pro Glu Asn Phe 
1               5                   10                  


<210>  18
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Extended p53-d

<400>  18

Thr Ser Phe Ser Glu Tyr Trp Lys Leu Leu Pro Glu Asn Tyr 
1               5                   10                  


<210>  19
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-01 (uncapped)


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<400>  19

Thr Ser Phe Xaa Glu Tyr Trp Xaa Leu Leu Pro Glu Asn Phe 
1               5                   10                  


<210>  20
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-02 (uncapped)


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is either (S)-2-(4'-pentenyl)alanine or 
       (R)-2-(4'-pentenyl)alanine

<400>  20

Thr Ser Phe Xaa Glu Tyr Trp Xaa Leu Leu Pro Glu Asn Tyr 
1               5                   10                  


<210>  21
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-03 (uncapped)


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  21

Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu Asn Phe 
1               5                   10                  


<210>  22
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  YS-04 (uncapped)


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  22

Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa Glu Asn Tyr 
1               5                   10                  


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  12-1 peptide

<400>  23

Arg Phe Met Asp Tyr Trp Glu Gly Leu 
1               5                   


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  sMTide-02 (capped; meaning acetylated N-terminus, NH2 at 
       C-terminus)


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is either (R)-2-(7'-octenyl)alanine or 
       (S)-2-(7'-octenyl)alanine

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is (S)-2-(4'-pentenyl)alanine

<400>  24

Thr Ser Phe Xaa Glu Tyr Trp Ala Leu Leu Xaa 
1               5                   10      


<210>  25
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Mdm2-binding epitope

<400>  25

Phe Ser Asp Leu Trp Lys Leu Leu 
1               5               


<210>  26
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  p53 WT-2

<400>  26

Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu 
1               5                   10          


