                               SEQUENCE LISTING

<110> DUKE UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR EPIGENOME EDITING

<130> 028193-9190-WO00

<140> PCT/US2016/017221
<141> 2016-02-09

<150> 62/113,569
<151> 2015-02-09

<160> 278   

<170> PatentIn version 3.5

<210> 1
<211> 1368
<212> PRT
<213> Streptococcus pyogenes

<400> 1
Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 2
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Met Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210> 3
<211> 617
<212> PRT
<213> Homo sapiens

<400> 3
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Ser Tyr Leu Asp 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr His 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Thr 
    370                 375                 380                 


Thr Gly His Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 4
<211> 617
<212> PRT
<213> Homo sapiens

<400> 4
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Ser Tyr Leu Tyr 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr His 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Thr 
    370                 375                 380                 


Thr Gly His Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 5
<211> 617
<212> PRT
<213> Homo sapiens

<400> 5
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Ser Tyr Leu Asp 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr His 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Thr 
    370                 375                 380                 


Thr Gly His Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Glu Glu Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 6
<211> 617
<212> PRT
<213> Homo sapiens

<400> 6
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Arg Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Ser Tyr Leu Asp 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr His 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Thr 
    370                 375                 380                 


Thr Gly His Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 7
<211> 617
<212> PRT
<213> Homo sapiens

<400> 7
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Ser Tyr Leu Asp 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr His 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Thr 
    370                 375                 380                 


Thr Gly His Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Phe Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 8
<211> 617
<212> PRT
<213> Homo sapiens

<400> 8
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Trp Trp Leu Asp 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr His 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Glu Tyr Val Lys Lys Leu Gly Tyr Thr 
    370                 375                 380                 


Thr Gly His Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 9
<211> 617
<212> PRT
<213> Homo sapiens

<400> 9
Ile Phe Lys Pro Glu Glu Leu Arg Gln Ala Leu Met Pro Thr Leu Glu 
1               5                   10                  15      


Ala Leu Tyr Arg Gln Asp Pro Glu Ser Leu Pro Phe Arg Gln Pro Val 
            20                  25                  30          


Asp Pro Gln Leu Leu Gly Ile Pro Asp Tyr Phe Asp Ile Val Lys Ser 
        35                  40                  45              


Pro Met Asp Leu Ser Thr Ile Lys Arg Lys Leu Asp Thr Gly Gln Tyr 
    50                  55                  60                  


Gln Glu Pro Trp Gln Tyr Val Asp Asp Ile Trp Leu Met Phe Asn Asn 
65                  70                  75                  80  


Ala Trp Leu Tyr Asn Arg Lys Thr Ser Arg Val Tyr Lys Tyr Cys Ser 
                85                  90                  95      


Lys Leu Ser Glu Val Phe Glu Gln Glu Ile Asp Pro Val Met Gln Ser 
            100                 105                 110         


Leu Gly Tyr Cys Cys Gly Arg Lys Leu Glu Phe Ser Pro Gln Thr Leu 
        115                 120                 125             


Cys Cys Tyr Gly Lys Gln Leu Cys Thr Ile Pro Arg Asp Ala Thr Tyr 
    130                 135                 140                 


Tyr Ser Tyr Gln Asn Arg Tyr His Phe Cys Glu Lys Cys Phe Asn Glu 
145                 150                 155                 160 


Ile Gln Gly Glu Ser Val Ser Leu Gly Asp Asp Pro Ser Gln Pro Gln 
                165                 170                 175     


Thr Thr Ile Asn Lys Glu Gln Phe Ser Lys Arg Lys Asn Asp Thr Leu 
            180                 185                 190         


Asp Pro Glu Leu Phe Val Glu Cys Thr Glu Cys Gly Arg Lys Met His 
        195                 200                 205             


Gln Ile Cys Val Leu His His Glu Ile Ile Trp Pro Ala Gly Phe Val 
    210                 215                 220                 


Cys Asp Gly Cys Leu Lys Lys Ser Ala Arg Thr Arg Lys Glu Asn Lys 
225                 230                 235                 240 


Phe Ser Ala Lys Arg Leu Pro Ser Thr Arg Leu Gly Thr Phe Leu Glu 
                245                 250                 255     


Asn Arg Val Asn Asp Phe Leu Arg Arg Gln Asn His Pro Glu Ser Gly 
            260                 265                 270         


Glu Val Thr Val Arg Val Val His Ala Ser Asp Lys Thr Val Glu Val 
        275                 280                 285             


Lys Pro Gly Met Lys Ala Arg Phe Val Asp Ser Gly Glu Met Ala Glu 
    290                 295                 300                 


Ser Phe Pro Tyr Arg Thr Lys Ala Leu Phe Ala Phe Glu Glu Ile Asp 
305                 310                 315                 320 


Gly Val Asp Leu Cys Phe Phe Gly Met His Val Gln Glu Tyr Gly Ser 
                325                 330                 335     


Asp Cys Pro Pro Pro Asn Gln Arg Arg Val Tyr Ile Ser Tyr Leu Asp 
            340                 345                 350         


Ser Val His Phe Phe Arg Pro Lys Cys Leu Arg Thr Ala Val Tyr Ala 
        355                 360                 365             


Glu Ile Leu Ile Gly Tyr Leu Ala Ala Val Lys Lys Ser Gly Ala Thr 
    370                 375                 380                 


Thr Gly Ala Ile Trp Ala Cys Pro Pro Ser Glu Gly Asp Asp Tyr Ile 
385                 390                 395                 400 


Phe His Cys His Pro Pro Asp Gln Lys Ile Pro Lys Pro Lys Arg Leu 
                405                 410                 415     


Gln Glu Trp Tyr Lys Lys Met Leu Asp Lys Ala Val Ser Glu Arg Ile 
            420                 425                 430         


Val His Asp Tyr Lys Asp Ile Phe Lys Gln Ala Thr Glu Asp Arg Leu 
        435                 440                 445             


Thr Ser Ala Lys Glu Leu Pro Tyr Phe Glu Gly Asp Phe Trp Pro Asn 
    450                 455                 460                 


Val Leu Glu Glu Ser Ile Lys Glu Leu Glu Gln Glu Glu Glu Glu Arg 
465                 470                 475                 480 


Lys Arg Glu Glu Asn Thr Ser Asn Glu Ser Thr Asp Val Thr Lys Gly 
                485                 490                 495     


Asp Ser Lys Asn Ala Lys Lys Lys Asn Asn Lys Lys Thr Ser Lys Asn 
            500                 505                 510         


Lys Ser Ser Leu Ser Arg Gly Asn Lys Lys Lys Pro Gly Met Pro Asn 
        515                 520                 525             


Val Ser Asn Asp Leu Ser Gln Lys Leu Tyr Ala Thr Met Glu Lys His 
    530                 535                 540                 


Lys Glu Val Phe Phe Val Ile Arg Leu Ile Ala Gly Pro Ala Ala Asn 
545                 550                 555                 560 


Ser Leu Pro Pro Ile Val Asp Pro Asp Pro Leu Ile Pro Cys Asp Leu 
                565                 570                 575     


Met Asp Gly Arg Asp Ala Phe Leu Thr Leu Ala Arg Asp Lys His Leu 
            580                 585                 590         


Glu Phe Ser Ser Leu Arg Arg Ala Gln Trp Ser Thr Met Cys Met Leu 
        595                 600                 605             


Val Glu Leu His Thr Gln Ser Gln Asp 
    610                 615         


<210> 10
<211> 1082
<212> PRT
<213> Neisseria meningitidis

<400> 10
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Ala 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Ala Ala Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Ala Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg 
    1070                 1075                 1080         


<210> 11
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Pro Lys Lys Lys Arg Lys Val Gly 
1               5               


<210> 13
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
1               5                   10  


<210> 14
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
1               5                   10                  15      


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
            20                  25                  30          


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        35                  40                  45              


Met Leu 
    50  


<210> 15
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 15
gggctcctcc ttgtact                                                      17


<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
acgcagataa gaaccagt                                                     18


<210> 17
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
ggcatcaagt cagccat                                                      17


<210> 18
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
agcctgagtc accctcct                                                     18


<210> 19
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
gggctcctcc ttgtact                                                      17


<210> 20
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
acgcagataa gaaccagt                                                     18


<210> 21
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ggcatcaagt cagccat                                                      17


<210> 22
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
agcctgagtc accctcct                                                     18


<210> 23
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
tgtactctct gaggtgctc                                                    19


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
acgcagataa gaaccagtt                                                    19


<210> 25
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
catcaagtca gccatcagc                                                    19


<210> 26
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
gagtcaccct cctggaaac                                                    19


<210> 27
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 27
cctgggctcc ggggcgttt                                                    19


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 28
ggcccctgcg gccaccccg                                                    19


<210> 29
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
ctccctccct gcccggtag                                                    19


<210> 30
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
aggtttggaa agggcgtgc                                                    19


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
actccactgc actccagtct                                                   20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
tctgtggggg acctgcactg                                                   20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
ggggcgccag ttgtgtctcc                                                   20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
acaccattgc caccaccatt                                                   20


<210> 35
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
tgttttcagc ttccaaact                                                    19


<210> 36
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 36
catgaagaca gcagaagcc                                                    19


<210> 37
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 37
ggcccacatt cctttccag                                                    19


<210> 38
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 38
ggctggattg ggtttccag                                                    19


<210> 39
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 39
caactgagtc ctgaggttt                                                    19


<210> 40
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 40
ctcacagcac agccagtgt                                                    19


<210> 41
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 41
cagcagctgg tcacaaagc                                                    19


<210> 42
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 42
cttcctataa acttctgag                                                    19


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 43
agtgataaga cacccgcttt                                                   20


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 44
cagacatcta ataccacggt                                                   20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 45
agggagaacg gggcctaccg                                                   20


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 46
acttcaggtt caaagaagcc                                                   20


<210> 47
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 47
ttttccccac ccagggccta                                                   20


<210> 48
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 48
ccctgggtgg ggaaaaccag                                                   20


<210> 49
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 49
ggaggaacat gcttcggaac                                                   20


<210> 50
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
gtgccgtgat ggttctgtcc                                                   20


<210> 51
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 51
ggtctgccgg aaggtctaca                                                   20


<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 52
tcggccttta actgcccaaa                                                   20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 53
gcatgacaaa ggtgccgtga                                                   20


<210> 54
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 54
cctgcctttt gggcagttaa                                                   20


<210> 55
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 55
aatatgtcac attctgtctc                                                   20


<210> 56
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 56
ggactatggg aggtcactaa                                                   20


<210> 57
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 57
gaaggttaca cagaaccaga                                                   20


<210> 58
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 58
gccctgtaag catcctgctg                                                   20


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 59
ccactgctaa ctgaaagaga                                                   20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 60
agccacagtt tcagcgcagt                                                   20


<210> 61
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
ctgtttcatc ttagaaaaat                                                   20


<210> 62
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 62
gaatgttctt tggcaggtac                                                   20


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
cgcacatctt atgtcttaga                                                   20


<210> 64
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
cttaagagag ctagaactgg                                                   20


<210> 65
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
tcccaaagta cagtaccttg                                                   20


<210> 66
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
tccctagaga ggacagacag                                                   20


<210> 67
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
tcatagagaa atgaaaagag                                                   20


<210> 68
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 68
ataatatacc ctgactccta                                                   20


<210> 69
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 69
aggccacctg caagataaat                                                   20


<210> 70
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 70
tgttgttatc aattgccata                                                   20


<210> 71
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
atcccttcca gcatcctcat                                                   20


<210> 72
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
gtgcttcaaa accatttgct                                                   20


<210> 73
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 73
gatacatgtt ttattcttat                                                   20


<210> 74
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 74
caatgacccc ttcattgacc                                                   20


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 75
ttgattttgg agggatctcg                                                   20


<210> 76
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 76
ggaatccatg gagggaagat                                                   20


<210> 77
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 77
tgttctcgct caggtcagtg                                                   20


<210> 78
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 78
tccctctttc acggtctcac                                                   20


<210> 79
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 79
aacacccgac tgctgtatcc                                                   20


<210> 80
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 80
cgaaagagaa agcgaaccag tatcgagaac                                        30


<210> 81
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 81
cgttgtgcat agtcgctgct tgatcgc                                           27


<210> 82
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 82
gcacgtggat cctgagaact                                                   20


<210> 83
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 83
attggacagc aagaaagcga g                                                 21


<210> 84
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 84
gcacgtggat cctgagaact                                                   20


<210> 85
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 85
caggaaacag tccaggatct ca                                                22


<210> 86
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 86
gctgagtgaa ctgcactgtg a                                                 21


<210> 87
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 87
gaattctttg ccgaaatgga                                                   20


<210> 88
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 88
tcactagcaa gctctcaggc                                                   20


<210> 89
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 89
aacaacgagg agtctgccc                                                    19


<210> 90
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 90
gcagacagtg accatctaca gctt                                              24


<210> 91
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 91
caatccctct cgtccagtcg                                                   20


<210> 92
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 92
tgcttggact atgggaggtc                                                   20


<210> 93
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 93
gcaggtgctt caaaaccatt                                                   20


<210> 94
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 94
tcaggtggtc agcttctcct                                                   20


<210> 95
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 95
aagcaaacct tctggctcaa                                                   20


<210> 96
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 96
ccacacaggt gaaccctttt                                                   20


<210> 97
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 97
ggacacatgc tcacatacgg                                                   20


<210> 98
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 98
attcgatcca tgtgcctga                                                    19


<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 99
caatgctgga atttgtggaa                                                   20


<210> 100
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 100
ggggtgattc cctagagagg                                                   20


<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 101
aagcaggaca gacaggcaag                                                   20


<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 102
gagggtcagc agtgatggat                                                   20


<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 103
tggaaaagga gaatgggaga                                                   20


<210> 104
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 104
tggtcaagtt tgccttgtca                                                   20


<210> 105
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 105
ggaatgactg aatcggaaca a                                                 21


<210> 106
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 106
cctccagcat cttccacatt                                                   20


<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 107
gaagcaccct tcagcagttc                                                   20


<210> 108
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 108
ccacagtttc agcgcagtaa ta                                                22


<210> 109
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 109
atcagccagc acacacactt                                                   20


<210> 110
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 110
ccctgtcagg agggacagat                                                   20


<210> 111
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 111
ggctcaccgg aagcatgaat                                                   20


<210> 112
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 112
aagctacaag caggttcgct                                                   20


<210> 113
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 113
aataacaggg tccatcccgc                                                   20


<210> 114
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 114
tgttccctcc acctggaata                                                   20


<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 115
gggaaaatcc aaagcaggat                                                   20


<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 116
tcctaggtcc ctcaaaagca                                                   20


<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 117
gtccccaacg ctctaacaaa                                                   20


<210> 118
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 118
gttagagcgt tggggacctt                                                   20


<210> 119
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 119
cacatgcaga gaactgagct g                                                 21


<210> 120
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 120
gttggggtaa gcacgaagg                                                    19


<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 121
tttccaggag ggtgactcag                                                   20


<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 122
ttctctgcat gtgacctccc                                                   20


<210> 123
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 123
acacactcac agagggttgg                                                   20


<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 124
tgagtcaccc tcctggaaac                                                   20


<210> 125
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 125
ctccttccag agcacctcag                                                   20


<210> 126
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 126
gctgggctcc tccttgtact                                                   20


<210> 127
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 127
gctgctgccc ataaagtagc                                                   20


<210> 128
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 128
ggactgtggc ccaggtact                                                    19


<210> 129
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 129
ggcctcatag gacaggaggt                                                   20


<210> 130
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 130
ttatgggcag cagctcagtt                                                   20


<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 131
gacattttcc tggacgcttg                                                   20


<210> 132
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 132
ccctccccat ggctttaggt                                                   20


<210> 133
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 133
agctccatgc gcttgacatt                                                   20


<210> 134
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 134
agcgtccagg aaaatgtcaa                                                   20


<210> 135
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 135
atgaccctca cactccaagg                                                   20


<210> 136
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 136
gttgggtgct ccagctttta                                                   20


<210> 137
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 137
cctcaaaact cctggactcg                                                   20


<210> 138
<211> 1434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 138
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Leu Ile Asn Tyr  Pro Tyr Asp 
    1415                 1420                 1425             


Val Pro  Asp Tyr Ala Ser 
    1430                 


<210> 139
<211> 1483
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 139
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Asp Ala Leu Asp  Asp Phe Asp 
    1415                 1420                 1425             


Leu Asp  Met Leu Gly Ser Asp  Ala Leu Asp Asp Phe  Asp Leu Asp 
    1430                 1435                 1440             


Met Leu  Gly Ser Asp Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu 
    1445                 1450                 1455             


Gly Ser  Asp Ala Leu Asp Asp  Phe Asp Leu Asp Met  Leu Ile Asn 
    1460                 1465                 1470             


Tyr Pro  Tyr Asp Val Pro Asp  Tyr Ala Ser 
    1475                 1480             


<210> 140
<211> 3844
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 140
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ala Glu Asn Val  Val Glu Pro 
    1415                 1420                 1425             


Gly Pro  Pro Ser Ala Lys Arg  Pro Lys Leu Ser Ser  Pro Ala Leu 
    1430                 1435                 1440             


Ser Ala  Ser Ala Ser Asp Gly  Thr Asp Phe Gly Ser  Leu Phe Asp 
    1445                 1450                 1455             


Leu Glu  His Asp Leu Pro Asp  Glu Leu Ile Asn Ser  Thr Glu Leu 
    1460                 1465                 1470             


Gly Leu  Thr Asn Gly Gly Asp  Ile Asn Gln Leu Gln  Thr Ser Leu 
    1475                 1480                 1485             


Gly Met  Val Gln Asp Ala Ala  Ser Lys His Lys Gln  Leu Ser Glu 
    1490                 1495                 1500             


Leu Leu  Arg Ser Gly Ser Ser  Pro Asn Leu Asn Met  Gly Val Gly 
    1505                 1510                 1515             


Gly Pro  Gly Gln Val Met Ala  Ser Gln Ala Gln Gln  Ser Ser Pro 
    1520                 1525                 1530             


Gly Leu  Gly Leu Ile Asn Ser  Met Val Lys Ser Pro  Met Thr Gln 
    1535                 1540                 1545             


Ala Gly  Leu Thr Ser Pro Asn  Met Gly Met Gly Thr  Ser Gly Pro 
    1550                 1555                 1560             


Asn Gln  Gly Pro Thr Gln Ser  Thr Gly Met Met Asn  Ser Pro Val 
    1565                 1570                 1575             


Asn Gln  Pro Ala Met Gly Met  Asn Thr Gly Met Asn  Ala Gly Met 
    1580                 1585                 1590             


Asn Pro  Gly Met Leu Ala Ala  Gly Asn Gly Gln Gly  Ile Met Pro 
    1595                 1600                 1605             


Asn Gln  Val Met Asn Gly Ser  Ile Gly Ala Gly Arg  Gly Arg Gln 
    1610                 1615                 1620             


Asn Met  Gln Tyr Pro Asn Pro  Gly Met Gly Ser Ala  Gly Asn Leu 
    1625                 1630                 1635             


Leu Thr  Glu Pro Leu Gln Gln  Gly Ser Pro Gln Met  Gly Gly Gln 
    1640                 1645                 1650             


Thr Gly  Leu Arg Gly Pro Gln  Pro Leu Lys Met Gly  Met Met Asn 
    1655                 1660                 1665             


Asn Pro  Asn Pro Tyr Gly Ser  Pro Tyr Thr Gln Asn  Pro Gly Gln 
    1670                 1675                 1680             


Gln Ile  Gly Ala Ser Gly Leu  Gly Leu Gln Ile Gln  Thr Lys Thr 
    1685                 1690                 1695             


Val Leu  Ser Asn Asn Leu Ser  Pro Phe Ala Met Asp  Lys Lys Ala 
    1700                 1705                 1710             


Val Pro  Gly Gly Gly Met Pro  Asn Met Gly Gln Gln  Pro Ala Pro 
    1715                 1720                 1725             


Gln Val  Gln Gln Pro Gly Leu  Val Thr Pro Val Ala  Gln Gly Met 
    1730                 1735                 1740             


Gly Ser  Gly Ala His Thr Ala  Asp Pro Glu Lys Arg  Lys Leu Ile 
    1745                 1750                 1755             


Gln Gln  Gln Leu Val Leu Leu  Leu His Ala His Lys  Cys Gln Arg 
    1760                 1765                 1770             


Arg Glu  Gln Ala Asn Gly Glu  Val Arg Gln Cys Asn  Leu Pro His 
    1775                 1780                 1785             


Cys Arg  Thr Met Lys Asn Val  Leu Asn His Met Thr  His Cys Gln 
    1790                 1795                 1800             


Ser Gly  Lys Ser Cys Gln Val  Ala His Cys Ala Ser  Ser Arg Gln 
    1805                 1810                 1815             


Ile Ile  Ser His Trp Lys Asn  Cys Thr Arg His Asp  Cys Pro Val 
    1820                 1825                 1830             


Cys Leu  Pro Leu Lys Asn Ala  Gly Asp Lys Arg Asn  Gln Gln Pro 
    1835                 1840                 1845             


Ile Leu  Thr Gly Ala Pro Val  Gly Leu Gly Asn Pro  Ser Ser Leu 
    1850                 1855                 1860             


Gly Val  Gly Gln Gln Ser Ala  Pro Asn Leu Ser Thr  Val Ser Gln 
    1865                 1870                 1875             


Ile Asp  Pro Ser Ser Ile Glu  Arg Ala Tyr Ala Ala  Leu Gly Leu 
    1880                 1885                 1890             


Pro Tyr  Gln Val Asn Gln Met  Pro Thr Gln Pro Gln  Val Gln Ala 
    1895                 1900                 1905             


Lys Asn  Gln Gln Asn Gln Gln  Pro Gly Gln Ser Pro  Gln Gly Met 
    1910                 1915                 1920             


Arg Pro  Met Ser Asn Met Ser  Ala Ser Pro Met Gly  Val Asn Gly 
    1925                 1930                 1935             


Gly Val  Gly Val Gln Thr Pro  Ser Leu Leu Ser Asp  Ser Met Leu 
    1940                 1945                 1950             


His Ser  Ala Ile Asn Ser Gln  Asn Pro Met Met Ser  Glu Asn Ala 
    1955                 1960                 1965             


Ser Val  Pro Ser Met Gly Pro  Met Pro Thr Ala Ala  Gln Pro Ser 
    1970                 1975                 1980             


Thr Thr  Gly Ile Arg Lys Gln  Trp His Glu Asp Ile  Thr Gln Asp 
    1985                 1990                 1995             


Leu Arg  Asn His Leu Val His  Lys Leu Val Gln Ala  Ile Phe Pro 
    2000                 2005                 2010             


Thr Pro  Asp Pro Ala Ala Leu  Lys Asp Arg Arg Met  Glu Asn Leu 
    2015                 2020                 2025             


Val Ala  Tyr Ala Arg Lys Val  Glu Gly Asp Met Tyr  Glu Ser Ala 
    2030                 2035                 2040             


Asn Asn  Arg Ala Glu Tyr Tyr  His Leu Leu Ala Glu  Lys Ile Tyr 
    2045                 2050                 2055             


Lys Ile  Gln Lys Glu Leu Glu  Glu Lys Arg Arg Thr  Arg Leu Gln 
    2060                 2065                 2070             


Lys Gln  Asn Met Leu Pro Asn  Ala Ala Gly Met Val  Pro Val Ser 
    2075                 2080                 2085             


Met Asn  Pro Gly Pro Asn Met  Gly Gln Pro Gln Pro  Gly Met Thr 
    2090                 2095                 2100             


Ser Asn  Gly Pro Leu Pro Asp  Pro Ser Met Ile Arg  Gly Ser Val 
    2105                 2110                 2115             


Pro Asn  Gln Met Met Pro Arg  Ile Thr Pro Gln Ser  Gly Leu Asn 
    2120                 2125                 2130             


Gln Phe  Gly Gln Met Ser Met  Ala Gln Pro Pro Ile  Val Pro Arg 
    2135                 2140                 2145             


Gln Thr  Pro Pro Leu Gln His  His Gly Gln Leu Ala  Gln Pro Gly 
    2150                 2155                 2160             


Ala Leu  Asn Pro Pro Met Gly  Tyr Gly Pro Arg Met  Gln Gln Pro 
    2165                 2170                 2175             


Ser Asn  Gln Gly Gln Phe Leu  Pro Gln Thr Gln Phe  Pro Ser Gln 
    2180                 2185                 2190             


Gly Met  Asn Val Thr Asn Ile  Pro Leu Ala Pro Ser  Ser Gly Gln 
    2195                 2200                 2205             


Ala Pro  Val Ser Gln Ala Gln  Met Ser Ser Ser Ser  Cys Pro Val 
    2210                 2215                 2220             


Asn Ser  Pro Ile Met Pro Pro  Gly Ser Gln Gly Ser  His Ile His 
    2225                 2230                 2235             


Cys Pro  Gln Leu Pro Gln Pro  Ala Leu His Gln Asn  Ser Pro Ser 
    2240                 2245                 2250             


Pro Val  Pro Ser Arg Thr Pro  Thr Pro His His Thr  Pro Pro Ser 
    2255                 2260                 2265             


Ile Gly  Ala Gln Gln Pro Pro  Ala Thr Thr Ile Pro  Ala Pro Val 
    2270                 2275                 2280             


Pro Thr  Pro Pro Ala Met Pro  Pro Gly Pro Gln Ser  Gln Ala Leu 
    2285                 2290                 2295             


His Pro  Pro Pro Arg Gln Thr  Pro Thr Pro Pro Thr  Thr Gln Leu 
    2300                 2305                 2310             


Pro Gln  Gln Val Gln Pro Ser  Leu Pro Ala Ala Pro  Ser Ala Asp 
    2315                 2320                 2325             


Gln Pro  Gln Gln Gln Pro Arg  Ser Gln Gln Ser Thr  Ala Ala Ser 
    2330                 2335                 2340             


Val Pro  Thr Pro Thr Ala Pro  Leu Leu Pro Pro Gln  Pro Ala Thr 
    2345                 2350                 2355             


Pro Leu  Ser Gln Pro Ala Val  Ser Ile Glu Gly Gln  Val Ser Asn 
    2360                 2365                 2370             


Pro Pro  Ser Thr Ser Ser Thr  Glu Val Asn Ser Gln  Ala Ile Ala 
    2375                 2380                 2385             


Glu Lys  Gln Pro Ser Gln Glu  Val Lys Met Glu Ala  Lys Met Glu 
    2390                 2395                 2400             


Val Asp  Gln Pro Glu Pro Ala  Asp Thr Gln Pro Glu  Asp Ile Ser 
    2405                 2410                 2415             


Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu Ser Thr  Glu Thr Glu 
    2420                 2425                 2430             


Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile Lys Glu  Glu Glu Asp 
    2435                 2440                 2445             


Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser Pro Ala  Pro Gly Gln 
    2450                 2455                 2460             


Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu Leu Arg  Gln Ala Leu 
    2465                 2470                 2475             


Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln Asp Pro  Glu Ser Leu 
    2480                 2485                 2490             


Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu Leu Gly  Ile Pro Asp 
    2495                 2500                 2505             


Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp Leu Ser  Thr Ile Lys 
    2510                 2515                 2520             


Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu Pro Trp  Gln Tyr Val 
    2525                 2530                 2535             


Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala Trp Leu  Tyr Asn Arg 
    2540                 2545                 2550             


Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser Lys Leu  Ser Glu Val 
    2555                 2560                 2565             


Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln Ser Leu  Gly Tyr Cys 
    2570                 2575                 2580             


Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln Thr Leu  Cys Cys Tyr 
    2585                 2590                 2595             


Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp Ala Thr  Tyr Tyr Ser 
    2600                 2605                 2610             


Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys Cys Phe  Asn Glu Ile 
    2615                 2620                 2625             


Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp Pro Ser  Gln Pro Gln 
    2630                 2635                 2640             


Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys Arg Lys  Asn Asp Thr 
    2645                 2650                 2655             


Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr Glu Cys  Gly Arg Lys 
    2660                 2665                 2670             


Met His  Gln Ile Cys Val Leu  His His Glu Ile Ile  Trp Pro Ala 
    2675                 2680                 2685             


Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys Ser Ala  Arg Thr Arg 
    2690                 2695                 2700             


Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu Pro Ser  Thr Arg Leu 
    2705                 2710                 2715             


Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp Phe Leu  Arg Arg Gln 
    2720                 2725                 2730             


Asn His  Pro Glu Ser Gly Glu  Val Thr Val Arg Val  Val His Ala 
    2735                 2740                 2745             


Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly Met Lys  Ala Arg Phe 
    2750                 2755                 2760             


Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe Pro Tyr  Arg Thr Lys 
    2765                 2770                 2775             


Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly Val Asp  Leu Cys Phe 
    2780                 2785                 2790             


Phe Gly  Met His Val Gln Glu  Tyr Gly Ser Asp Cys  Pro Pro Pro 
    2795                 2800                 2805             


Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu Asp Ser  Val His Phe 
    2810                 2815                 2820             


Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val Tyr His  Glu Ile Leu 
    2825                 2830                 2835             


Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu Gly Tyr  Thr Thr Gly 
    2840                 2845                 2850             


His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly Asp Asp  Tyr Ile Phe 
    2855                 2860                 2865             


His Cys  His Pro Pro Asp Gln  Lys Ile Pro Lys Pro  Lys Arg Leu 
    2870                 2875                 2880             


Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys Ala Val  Ser Glu Arg 
    2885                 2890                 2895             


Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys Gln Ala  Thr Glu Asp 
    2900                 2905                 2910             


Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr Phe Glu  Gly Asp Phe 
    2915                 2920                 2925             


Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys Glu Leu  Glu Gln Glu 
    2930                 2935                 2940             


Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr Ser Asn  Glu Ser Thr 
    2945                 2950                 2955             


Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala Lys Lys  Lys Asn Asn 
    2960                 2965                 2970             


Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu Ser Arg  Gly Asn Lys 
    2975                 2980                 2985             


Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn Asp Leu  Ser Gln Lys 
    2990                 2995                 3000             


Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu Val Phe  Phe Val Ile 
    3005                 3010                 3015             


Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser Leu Pro  Pro Ile Val 
    3020                 3025                 3030             


Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu Met Asp  Gly Arg Asp 
    3035                 3040                 3045             


Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His Leu Glu  Phe Ser Ser 
    3050                 3055                 3060             


Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys Met Leu  Val Glu Leu 
    3065                 3070                 3075             


His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr Thr Cys  Asn Glu Cys 
    3080                 3085                 3090             


Lys His  His Val Glu Thr Arg  Trp His Cys Thr Val  Cys Glu Asp 
    3095                 3100                 3105             


Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr Lys Asn  His Asp His 
    3110                 3115                 3120             


Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp Asp Glu  Ser Asn Asn 
    3125                 3130                 3135             


Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly Asp Ser  Arg Arg Leu 
    3140                 3145                 3150             


Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val His Ala  Cys Gln Cys 
    3155                 3160                 3165             


Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys Gln Lys  Met Lys Arg 
    3170                 3175                 3180             


Val Val  Gln His Thr Lys Gly  Cys Lys Arg Lys Thr  Asn Gly Gly 
    3185                 3190                 3195             


Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu Cys Cys  Tyr His Ala 
    3200                 3205                 3210             


Lys His  Cys Gln Glu Asn Lys  Cys Pro Val Pro Phe  Cys Leu Asn 
    3215                 3220                 3225             


Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu Gln His  Arg Leu Gln 
    3230                 3235                 3240             


Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala Ser Met  Gln Arg Thr 
    3245                 3250                 3255             


Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro Ser Pro  Thr Pro Ala 
    3260                 3265                 3270             


Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro Thr Thr  Pro Gln Thr 
    3275                 3280                 3285             


Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr Pro Pro  Asn Ser Met 
    3290                 3295                 3300             


Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala Gly Pro  Val Ser Gln 
    3305                 3310                 3315             


Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro Thr Pro  Pro Gln Thr 
    3320                 3325                 3330             


Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro Ala Ala  Val Glu Met 
    3335                 3340                 3345             


Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr Gln Arg  Gln Met Ala 
    3350                 3355                 3360             


His Val  Gln Ile Phe Gln Arg  Pro Ile Gln His Gln  Met Pro Pro 
    3365                 3370                 3375             


Met Thr  Pro Met Ala Pro Met  Gly Met Asn Pro Pro  Pro Met Thr 
    3380                 3385                 3390             


Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly Met Gly  Pro Thr Gly 
    3395                 3400                 3405             


Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly Gly Leu  Pro Gln Pro 
    3410                 3415                 3420             


Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro Ala Met  Met Ser Val 
    3425                 3430                 3435             


Ala Gln  His Gly Gln Pro Leu  Asn Met Ala Pro Gln  Pro Gly Leu 
    3440                 3445                 3450             


Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro Gly Thr  Val Ser Gln 
    3455                 3460                 3465             


Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu Arg Ser  Pro Ser Ser 
    3470                 3475                 3480             


Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile Leu His  Ala Asn Pro 
    3485                 3490                 3495             


Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg Ala Ala  Lys Tyr Ala 
    3500                 3505                 3510             


Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln Pro Gly  Met Pro Gln 
    3515                 3520                 3525             


Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met Pro Gly  Gln Gln Gly 
    3530                 3535                 3540             


Val His  Ser Asn Pro Ala Met  Gln Asn Met Asn Pro  Met Gln Ala 
    3545                 3550                 3555             


Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln Gln Pro  Gln Gln Gln 
    3560                 3565                 3570             


Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro Gln Ala  Gln Gln Met 
    3575                 3580                 3585             


Asn Met  Asn His Asn Thr Met  Pro Ser Gln Phe Arg  Asp Ile Leu 
    3590                 3595                 3600             


Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln Gln Gln  Gly Ala Gly 
    3605                 3610                 3615             


Pro Gly  Ile Gly Pro Gly Met  Ala Asn His Asn Gln  Phe Gln Gln 
    3620                 3625                 3630             


Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln Gln Gln  Arg Met Gln 
    3635                 3640                 3645             


His His  Met Gln Gln Met Gln  Gln Gly Asn Met Gly  Gln Ile Gly 
    3650                 3655                 3660             


Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala Gly Ala  Ser Leu Gln 
    3665                 3670                 3675             


Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln Met Gly  Ser Pro Val 
    3680                 3685                 3690             


Gln Pro  Asn Pro Met Ser Pro  Gln Gln His Met Leu  Pro Asn Gln 
    3695                 3700                 3705             


Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln Ile Pro  Asn Ser Leu 
    3710                 3715                 3720             


Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val Pro Ser  Pro Arg Pro 
    3725                 3730                 3735             


Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser Pro Arg  Met Gln Pro 
    3740                 3745                 3750             


Gln Pro  Ser Pro His His Val  Ser Pro Gln Thr Ser  Ser Pro His 
    3755                 3760                 3765             


Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro Met Glu  Gln Gly His 
    3770                 3775                 3780             


Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu Ser Gln  Leu Ala Ser 
    3785                 3790                 3795             


Asn Pro  Gly Met Ala Asn Leu  His Gly Ala Ser Ala  Thr Asp Leu 
    3800                 3805                 3810             


Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn Ser Asn  Leu Ser Gln 
    3815                 3820                 3825             


Ser Thr  Leu Asp Ile His Tyr  Pro Tyr Asp Val Pro  Asp Tyr Ala 
    3830                 3835                 3840             


Ser 
    


<210> 141
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 141
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 142
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 142
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Tyr 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 143
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 143
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Glu Glu  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 144
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 144
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Arg 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 145
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 145
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Phe Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 146
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 146
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Trp  Trp Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


His Glu  Ile Leu Ile Gly Tyr  Leu Glu Tyr Val Lys  Lys Leu Gly 
    1790                 1795                 1800             


Tyr Thr  Thr Gly His Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 147
<211> 2048
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 147
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1085                 1090                 1095             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1100                 1105                 1110             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1115                 1120                 1125             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1130                 1135                 1140             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1145                 1150                 1155             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1160                 1165                 1170             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1175                 1180                 1185             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1190                 1195                 1200             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1205                 1210                 1215             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1220                 1225                 1230             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1235                 1240                 1245             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1250                 1255                 1260             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1265                 1270                 1275             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1280                 1285                 1290             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1295                 1300                 1305             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1310                 1315                 1320             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1325                 1330                 1335             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1340                 1345                 1350             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1355                 1360                 1365             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1370                 1375                 1380             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1385                 1390                 1395             


Gln Leu  Gly Gly Asp Pro Ile  Ala Gly Ser Lys Ala  Ser Pro Lys 
    1400                 1405                 1410             


Lys Lys  Arg Lys Val Gly Arg  Ala Ile Phe Lys Pro  Glu Glu Leu 
    1415                 1420                 1425             


Arg Gln  Ala Leu Met Pro Thr  Leu Glu Ala Leu Tyr  Arg Gln Asp 
    1430                 1435                 1440             


Pro Glu  Ser Leu Pro Phe Arg  Gln Pro Val Asp Pro  Gln Leu Leu 
    1445                 1450                 1455             


Gly Ile  Pro Asp Tyr Phe Asp  Ile Val Lys Ser Pro  Met Asp Leu 
    1460                 1465                 1470             


Ser Thr  Ile Lys Arg Lys Leu  Asp Thr Gly Gln Tyr  Gln Glu Pro 
    1475                 1480                 1485             


Trp Gln  Tyr Val Asp Asp Ile  Trp Leu Met Phe Asn  Asn Ala Trp 
    1490                 1495                 1500             


Leu Tyr  Asn Arg Lys Thr Ser  Arg Val Tyr Lys Tyr  Cys Ser Lys 
    1505                 1510                 1515             


Leu Ser  Glu Val Phe Glu Gln  Glu Ile Asp Pro Val  Met Gln Ser 
    1520                 1525                 1530             


Leu Gly  Tyr Cys Cys Gly Arg  Lys Leu Glu Phe Ser  Pro Gln Thr 
    1535                 1540                 1545             


Leu Cys  Cys Tyr Gly Lys Gln  Leu Cys Thr Ile Pro  Arg Asp Ala 
    1550                 1555                 1560             


Thr Tyr  Tyr Ser Tyr Gln Asn  Arg Tyr His Phe Cys  Glu Lys Cys 
    1565                 1570                 1575             


Phe Asn  Glu Ile Gln Gly Glu  Ser Val Ser Leu Gly  Asp Asp Pro 
    1580                 1585                 1590             


Ser Gln  Pro Gln Thr Thr Ile  Asn Lys Glu Gln Phe  Ser Lys Arg 
    1595                 1600                 1605             


Lys Asn  Asp Thr Leu Asp Pro  Glu Leu Phe Val Glu  Cys Thr Glu 
    1610                 1615                 1620             


Cys Gly  Arg Lys Met His Gln  Ile Cys Val Leu His  His Glu Ile 
    1625                 1630                 1635             


Ile Trp  Pro Ala Gly Phe Val  Cys Asp Gly Cys Leu  Lys Lys Ser 
    1640                 1645                 1650             


Ala Arg  Thr Arg Lys Glu Asn  Lys Phe Ser Ala Lys  Arg Leu Pro 
    1655                 1660                 1665             


Ser Thr  Arg Leu Gly Thr Phe  Leu Glu Asn Arg Val  Asn Asp Phe 
    1670                 1675                 1680             


Leu Arg  Arg Gln Asn His Pro  Glu Ser Gly Glu Val  Thr Val Arg 
    1685                 1690                 1695             


Val Val  His Ala Ser Asp Lys  Thr Val Glu Val Lys  Pro Gly Met 
    1700                 1705                 1710             


Lys Ala  Arg Phe Val Asp Ser  Gly Glu Met Ala Glu  Ser Phe Pro 
    1715                 1720                 1725             


Tyr Arg  Thr Lys Ala Leu Phe  Ala Phe Glu Glu Ile  Asp Gly Val 
    1730                 1735                 1740             


Asp Leu  Cys Phe Phe Gly Met  His Val Gln Glu Tyr  Gly Ser Asp 
    1745                 1750                 1755             


Cys Pro  Pro Pro Asn Gln Arg  Arg Val Tyr Ile Ser  Tyr Leu Asp 
    1760                 1765                 1770             


Ser Val  His Phe Phe Arg Pro  Lys Cys Leu Arg Thr  Ala Val Tyr 
    1775                 1780                 1785             


Ala Glu  Ile Leu Ile Gly Tyr  Leu Ala Ala Val Lys  Lys Ser Gly 
    1790                 1795                 1800             


Ala Thr  Thr Gly Ala Ile Trp  Ala Cys Pro Pro Ser  Glu Gly Asp 
    1805                 1810                 1815             


Asp Tyr  Ile Phe His Cys His  Pro Pro Asp Gln Lys  Ile Pro Lys 
    1820                 1825                 1830             


Pro Lys  Arg Leu Gln Glu Trp  Tyr Lys Lys Met Leu  Asp Lys Ala 
    1835                 1840                 1845             


Val Ser  Glu Arg Ile Val His  Asp Tyr Lys Asp Ile  Phe Lys Gln 
    1850                 1855                 1860             


Ala Thr  Glu Asp Arg Leu Thr  Ser Ala Lys Glu Leu  Pro Tyr Phe 
    1865                 1870                 1875             


Glu Gly  Asp Phe Trp Pro Asn  Val Leu Glu Glu Ser  Ile Lys Glu 
    1880                 1885                 1890             


Leu Glu  Gln Glu Glu Glu Glu  Arg Lys Arg Glu Glu  Asn Thr Ser 
    1895                 1900                 1905             


Asn Glu  Ser Thr Asp Val Thr  Lys Gly Asp Ser Lys  Asn Ala Lys 
    1910                 1915                 1920             


Lys Lys  Asn Asn Lys Lys Thr  Ser Lys Asn Lys Ser  Ser Leu Ser 
    1925                 1930                 1935             


Arg Gly  Asn Lys Lys Lys Pro  Gly Met Pro Asn Val  Ser Asn Asp 
    1940                 1945                 1950             


Leu Ser  Gln Lys Leu Tyr Ala  Thr Met Glu Lys His  Lys Glu Val 
    1955                 1960                 1965             


Phe Phe  Val Ile Arg Leu Ile  Ala Gly Pro Ala Ala  Asn Ser Leu 
    1970                 1975                 1980             


Pro Pro  Ile Val Asp Pro Asp  Pro Leu Ile Pro Cys  Asp Leu Met 
    1985                 1990                 1995             


Asp Gly  Arg Asp Ala Phe Leu  Thr Leu Ala Arg Asp  Lys His Leu 
    2000                 2005                 2010             


Glu Phe  Ser Ser Leu Arg Arg  Ala Gln Trp Ser Thr  Met Cys Met 
    2015                 2020                 2025             


Leu Val  Glu Leu His Thr Gln  Ser Gln Asp Tyr Pro  Tyr Asp Val 
    2030                 2035                 2040             


Pro Asp  Tyr Ala Ser 
    2045             


<210> 148
<211> 1155
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 148
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Ala 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Ala Ala Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Ala Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg Ser 
    1070                 1075                 1080             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val Glu Ala  Ser Gly Ser 
    1085                 1090                 1095             


Gly Arg  Ala Asp Ala Leu Asp  Asp Phe Asp Leu Asp  Met Leu Gly 
    1100                 1105                 1110             


Ser Asp  Ala Leu Asp Asp Phe  Asp Leu Asp Met Leu  Gly Ser Asp 
    1115                 1120                 1125             


Ala Leu  Asp Asp Phe Asp Leu  Asp Met Leu Gly Ser  Asp Ala Leu 
    1130                 1135                 1140             


Asp Asp  Phe Asp Leu Asp Met  Leu Ile Asn Ser Arg  
    1145                 1150                 1155 


<210> 149
<211> 1726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 149
Met Ala Ala Phe Lys Pro Asn Pro Ile Asn Tyr Ile Leu Gly Leu Ala 
1               5                   10                  15      


Ile Gly Ile Ala Ser Val Gly Trp Ala Met Val Glu Ile Asp Glu Asp 
            20                  25                  30          


Glu Asn Pro Ile Cys Leu Ile Asp Leu Gly Val Arg Val Phe Glu Arg 
        35                  40                  45              


Ala Glu Val Pro Lys Thr Gly Asp Ser Leu Ala Met Ala Arg Arg Leu 
    50                  55                  60                  


Ala Arg Ser Val Arg Arg Leu Thr Arg Arg Arg Ala His Arg Leu Leu 
65                  70                  75                  80  


Arg Ala Arg Arg Leu Leu Lys Arg Glu Gly Val Leu Gln Ala Ala Asp 
                85                  90                  95      


Phe Asp Glu Asn Gly Leu Ile Lys Ser Leu Pro Asn Thr Pro Trp Gln 
            100                 105                 110         


Leu Arg Ala Ala Ala Leu Asp Arg Lys Leu Thr Pro Leu Glu Trp Ser 
        115                 120                 125             


Ala Val Leu Leu His Leu Ile Lys His Arg Gly Tyr Leu Ser Gln Arg 
    130                 135                 140                 


Lys Asn Glu Gly Glu Thr Ala Asp Lys Glu Leu Gly Ala Leu Leu Lys 
145                 150                 155                 160 


Gly Val Ala Asp Asn Ala His Ala Leu Gln Thr Gly Asp Phe Arg Thr 
                165                 170                 175     


Pro Ala Glu Leu Ala Leu Asn Lys Phe Glu Lys Glu Ser Gly His Ile 
            180                 185                 190         


Arg Asn Gln Arg Gly Asp Tyr Ser His Thr Phe Ser Arg Lys Asp Leu 
        195                 200                 205             


Gln Ala Glu Leu Ile Leu Leu Phe Glu Lys Gln Lys Glu Phe Gly Asn 
    210                 215                 220                 


Pro His Val Ser Gly Gly Leu Lys Glu Gly Ile Glu Thr Leu Leu Met 
225                 230                 235                 240 


Thr Gln Arg Pro Ala Leu Ser Gly Asp Ala Val Gln Lys Met Leu Gly 
                245                 250                 255     


His Cys Thr Phe Glu Pro Ala Glu Pro Lys Ala Ala Lys Asn Thr Tyr 
            260                 265                 270         


Thr Ala Glu Arg Phe Ile Trp Leu Thr Lys Leu Asn Asn Leu Arg Ile 
        275                 280                 285             


Leu Glu Gln Gly Ser Glu Arg Pro Leu Thr Asp Thr Glu Arg Ala Thr 
    290                 295                 300                 


Leu Met Asp Glu Pro Tyr Arg Lys Ser Lys Leu Thr Tyr Ala Gln Ala 
305                 310                 315                 320 


Arg Lys Leu Leu Gly Leu Glu Asp Thr Ala Phe Phe Lys Gly Leu Arg 
                325                 330                 335     


Tyr Gly Lys Asp Asn Ala Glu Ala Ser Thr Leu Met Glu Met Lys Ala 
            340                 345                 350         


Tyr His Ala Ile Ser Arg Ala Leu Glu Lys Glu Gly Leu Lys Asp Lys 
        355                 360                 365             


Lys Ser Pro Leu Asn Leu Ser Pro Glu Leu Gln Asp Glu Ile Gly Thr 
    370                 375                 380                 


Ala Phe Ser Leu Phe Lys Thr Asp Glu Asp Ile Thr Gly Arg Leu Lys 
385                 390                 395                 400 


Asp Arg Ile Gln Pro Glu Ile Leu Glu Ala Leu Leu Lys His Ile Ser 
                405                 410                 415     


Phe Asp Lys Phe Val Gln Ile Ser Leu Lys Ala Leu Arg Arg Ile Val 
            420                 425                 430         


Pro Leu Met Glu Gln Gly Lys Arg Tyr Asp Glu Ala Cys Ala Glu Ile 
        435                 440                 445             


Tyr Gly Asp His Tyr Gly Lys Lys Asn Thr Glu Glu Lys Ile Tyr Leu 
    450                 455                 460                 


Pro Pro Ile Pro Ala Asp Glu Ile Arg Asn Pro Val Val Leu Arg Ala 
465                 470                 475                 480 


Leu Ser Gln Ala Arg Lys Val Ile Asn Gly Val Val Arg Arg Tyr Gly 
                485                 490                 495     


Ser Pro Ala Arg Ile His Ile Glu Thr Ala Arg Glu Val Gly Lys Ser 
            500                 505                 510         


Phe Lys Asp Arg Lys Glu Ile Glu Lys Arg Gln Glu Glu Asn Arg Lys 
        515                 520                 525             


Asp Arg Glu Lys Ala Ala Ala Lys Phe Arg Glu Tyr Phe Pro Asn Phe 
    530                 535                 540                 


Val Gly Glu Pro Lys Ser Lys Asp Ile Leu Lys Leu Arg Leu Tyr Glu 
545                 550                 555                 560 


Gln Gln His Gly Lys Cys Leu Tyr Ser Gly Lys Glu Ile Asn Leu Gly 
                565                 570                 575     


Arg Leu Asn Glu Lys Gly Tyr Val Glu Ile Ala Ala Ala Leu Pro Phe 
            580                 585                 590         


Ser Arg Thr Trp Asp Asp Ser Phe Asn Asn Lys Val Leu Val Leu Gly 
        595                 600                 605             


Ser Glu Ala Gln Asn Lys Gly Asn Gln Thr Pro Tyr Glu Tyr Phe Asn 
    610                 615                 620                 


Gly Lys Asp Asn Ser Arg Glu Trp Gln Glu Phe Lys Ala Arg Val Glu 
625                 630                 635                 640 


Thr Ser Arg Phe Pro Arg Ser Lys Lys Gln Arg Ile Leu Leu Gln Lys 
                645                 650                 655     


Phe Asp Glu Asp Gly Phe Lys Glu Arg Asn Leu Asn Asp Thr Arg Tyr 
            660                 665                 670         


Val Asn Arg Phe Leu Cys Gln Phe Val Ala Asp Arg Met Arg Leu Thr 
        675                 680                 685             


Gly Lys Gly Lys Lys Arg Val Phe Ala Ser Asn Gly Gln Ile Thr Asn 
    690                 695                 700                 


Leu Leu Arg Gly Phe Trp Gly Leu Arg Lys Val Arg Ala Glu Asn Asp 
705                 710                 715                 720 


Arg His His Ala Leu Asp Ala Val Val Val Ala Cys Ser Thr Val Ala 
                725                 730                 735     


Met Gln Gln Lys Ile Thr Arg Phe Val Arg Tyr Lys Glu Met Asn Ala 
            740                 745                 750         


Phe Asp Gly Lys Thr Ile Asp Lys Glu Thr Gly Glu Val Leu His Gln 
        755                 760                 765             


Lys Thr His Phe Pro Gln Pro Trp Glu Phe Phe Ala Gln Glu Val Met 
    770                 775                 780                 


Ile Arg Val Phe Gly Lys Pro Asp Gly Lys Pro Glu Phe Glu Glu Ala 
785                 790                 795                 800 


Asp Thr Pro Glu Lys Leu Arg Thr Leu Leu Ala Glu Lys Leu Ser Ser 
                805                 810                 815     


Arg Pro Glu Ala Val His Glu Tyr Val Thr Pro Leu Phe Val Ser Arg 
            820                 825                 830         


Ala Pro Asn Arg Lys Met Ser Gly Gln Gly His Met Glu Thr Val Lys 
        835                 840                 845             


Ser Ala Lys Arg Leu Asp Glu Gly Val Ser Val Leu Arg Val Pro Leu 
    850                 855                 860                 


Thr Gln Leu Lys Leu Lys Asp Leu Glu Lys Met Val Asn Arg Glu Arg 
865                 870                 875                 880 


Glu Pro Lys Leu Tyr Glu Ala Leu Lys Ala Arg Leu Glu Ala His Lys 
                885                 890                 895     


Asp Asp Pro Ala Lys Ala Phe Ala Glu Pro Phe Tyr Lys Tyr Asp Lys 
            900                 905                 910         


Ala Gly Asn Arg Thr Gln Gln Val Lys Ala Val Arg Val Glu Gln Val 
        915                 920                 925             


Gln Lys Thr Gly Val Trp Val Arg Asn His Asn Gly Ile Ala Asp Asn 
    930                 935                 940                 


Ala Thr Met Val Arg Val Asp Val Phe Glu Lys Gly Asp Lys Tyr Tyr 
945                 950                 955                 960 


Leu Val Pro Ile Tyr Ser Trp Gln Val Ala Lys Gly Ile Leu Pro Asp 
                965                 970                 975     


Arg Ala Val Val Gln Gly Lys Asp Glu Glu Asp Trp Gln Leu Ile Asp 
            980                 985                 990         


Asp Ser Phe Asn Phe Lys Phe Ser  Leu His Pro Asn Asp  Leu Val Glu 
        995                 1000                 1005             


Val Ile  Thr Lys Lys Ala Arg  Met Phe Gly Tyr Phe  Ala Ser Cys 
    1010                 1015                 1020             


His Arg  Gly Thr Gly Asn Ile  Asn Ile Arg Ile His  Asp Leu Asp 
    1025                 1030                 1035             


His Lys  Ile Gly Lys Asn Gly  Ile Leu Glu Gly Ile  Gly Val Lys 
    1040                 1045                 1050             


Thr Ala  Leu Ser Phe Gln Lys  Tyr Gln Ile Asp Glu  Leu Gly Lys 
    1055                 1060                 1065             


Glu Ile  Arg Pro Cys Arg Leu  Lys Lys Arg Pro Pro  Val Arg Ser 
    1070                 1075                 1080             


Arg Ala  Asp Pro Lys Lys Lys  Arg Lys Val Glu Ala  Ser Gly Arg 
    1085                 1090                 1095             


Ala Ile  Phe Lys Pro Glu Glu  Leu Arg Gln Ala Leu  Met Pro Thr 
    1100                 1105                 1110             


Leu Glu  Ala Leu Tyr Arg Gln  Asp Pro Glu Ser Leu  Pro Phe Arg 
    1115                 1120                 1125             


Gln Pro  Val Asp Pro Gln Leu  Leu Gly Ile Pro Asp  Tyr Phe Asp 
    1130                 1135                 1140             


Ile Val  Lys Ser Pro Met Asp  Leu Ser Thr Ile Lys  Arg Lys Leu 
    1145                 1150                 1155             


Asp Thr  Gly Gln Tyr Gln Glu  Pro Trp Gln Tyr Val  Asp Asp Ile 
    1160                 1165                 1170             


Trp Leu  Met Phe Asn Asn Ala  Trp Leu Tyr Asn Arg  Lys Thr Ser 
    1175                 1180                 1185             


Arg Val  Tyr Lys Tyr Cys Ser  Lys Leu Ser Glu Val  Phe Glu Gln 
    1190                 1195                 1200             


Glu Ile  Asp Pro Val Met Gln  Ser Leu Gly Tyr Cys  Cys Gly Arg 
    1205                 1210                 1215             


Lys Leu  Glu Phe Ser Pro Gln  Thr Leu Cys Cys Tyr  Gly Lys Gln 
    1220                 1225                 1230             


Leu Cys  Thr Ile Pro Arg Asp  Ala Thr Tyr Tyr Ser  Tyr Gln Asn 
    1235                 1240                 1245             


Arg Tyr  His Phe Cys Glu Lys  Cys Phe Asn Glu Ile  Gln Gly Glu 
    1250                 1255                 1260             


Ser Val  Ser Leu Gly Asp Asp  Pro Ser Gln Pro Gln  Thr Thr Ile 
    1265                 1270                 1275             


Asn Lys  Glu Gln Phe Ser Lys  Arg Lys Asn Asp Thr  Leu Asp Pro 
    1280                 1285                 1290             


Glu Leu  Phe Val Glu Cys Thr  Glu Cys Gly Arg Lys  Met His Gln 
    1295                 1300                 1305             


Ile Cys  Val Leu His His Glu  Ile Ile Trp Pro Ala  Gly Phe Val 
    1310                 1315                 1320             


Cys Asp  Gly Cys Leu Lys Lys  Ser Ala Arg Thr Arg  Lys Glu Asn 
    1325                 1330                 1335             


Lys Phe  Ser Ala Lys Arg Leu  Pro Ser Thr Arg Leu  Gly Thr Phe 
    1340                 1345                 1350             


Leu Glu  Asn Arg Val Asn Asp  Phe Leu Arg Arg Gln  Asn His Pro 
    1355                 1360                 1365             


Glu Ser  Gly Glu Val Thr Val  Arg Val Val His Ala  Ser Asp Lys 
    1370                 1375                 1380             


Thr Val  Glu Val Lys Pro Gly  Met Lys Ala Arg Phe  Val Asp Ser 
    1385                 1390                 1395             


Gly Glu  Met Ala Glu Ser Phe  Pro Tyr Arg Thr Lys  Ala Leu Phe 
    1400                 1405                 1410             


Ala Phe  Glu Glu Ile Asp Gly  Val Asp Leu Cys Phe  Phe Gly Met 
    1415                 1420                 1425             


His Val  Gln Glu Tyr Gly Ser  Asp Cys Pro Pro Pro  Asn Gln Arg 
    1430                 1435                 1440             


Arg Val  Tyr Ile Ser Tyr Leu  Asp Ser Val His Phe  Phe Arg Pro 
    1445                 1450                 1455             


Lys Cys  Leu Arg Thr Ala Val  Tyr His Glu Ile Leu  Ile Gly Tyr 
    1460                 1465                 1470             


Leu Glu  Tyr Val Lys Lys Leu  Gly Tyr Thr Thr Gly  His Ile Trp 
    1475                 1480                 1485             


Ala Cys  Pro Pro Ser Glu Gly  Asp Asp Tyr Ile Phe  His Cys His 
    1490                 1495                 1500             


Pro Pro  Asp Gln Lys Ile Pro  Lys Pro Lys Arg Leu  Gln Glu Trp 
    1505                 1510                 1515             


Tyr Lys  Lys Met Leu Asp Lys  Ala Val Ser Glu Arg  Ile Val His 
    1520                 1525                 1530             


Asp Tyr  Lys Asp Ile Phe Lys  Gln Ala Thr Glu Asp  Arg Leu Thr 
    1535                 1540                 1545             


Ser Ala  Lys Glu Leu Pro Tyr  Phe Glu Gly Asp Phe  Trp Pro Asn 
    1550                 1555                 1560             


Val Leu  Glu Glu Ser Ile Lys  Glu Leu Glu Gln Glu  Glu Glu Glu 
    1565                 1570                 1575             


Arg Lys  Arg Glu Glu Asn Thr  Ser Asn Glu Ser Thr  Asp Val Thr 
    1580                 1585                 1590             


Lys Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1595                 1600                 1605             


Ser Lys  Asn Lys Ser Ser Leu  Ser Arg Gly Asn Lys  Lys Lys Pro 
    1610                 1615                 1620             


Gly Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1625                 1630                 1635             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  Arg Leu Ile 
    1640                 1645                 1650             


Ala Gly  Pro Ala Ala Asn Ser  Leu Pro Pro Ile Val  Asp Pro Asp 
    1655                 1660                 1665             


Pro Leu  Ile Pro Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1670                 1675                 1680             


Thr Leu  Ala Arg Asp Lys His  Leu Glu Phe Ser Ser  Leu Arg Arg 
    1685                 1690                 1695             


Ala Gln  Trp Ser Thr Met Cys  Met Leu Val Glu Leu  His Thr Gln 
    1700                 1705                 1710             


Ser Gln  Asp Tyr Pro Tyr Asp  Val Pro Asp Tyr Ala  Ser 
    1715                 1720                 1725     


<210> 150
<211> 295
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 150
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Ala Gln Ala Ala Leu Glu Pro Gly Glu Lys Pro Tyr 
        35                  40                  45              


Ala Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Cys Arg Asp Leu Ala 
    50                  55                  60                  


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
65                  70                  75                  80  


Cys Gly Lys Ser Phe Ser Arg Ser Asp Asp Leu Val Arg His Gln Arg 
                85                  90                  95      


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
            100                 105                 110         


Phe Ser Gln Ser Ser Asn Leu Val Arg His Gln Arg Thr His Thr Gly 
        115                 120                 125             


Glu Lys Pro Tyr Ala Cys Pro Glu Cys Gly Lys Ser Phe Ser Thr Ser 
    130                 135                 140                 


Gly Glu Leu Val Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
145                 150                 155                 160 


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Ala His Leu Glu 
                165                 170                 175     


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
            180                 185                 190         


Cys Gly Lys Ser Phe Ser Gln Ala Gly His Leu Ala Ser His Gln Arg 
        195                 200                 205             


Thr His Thr Gly Lys Lys Thr Ser Gly Gln Ala Gly Gln Ala Ser Pro 
    210                 215                 220                 


Lys Lys Lys Arg Lys Val Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp 
225                 230                 235                 240 


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
                245                 250                 255     


Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser 
            260                 265                 270         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Tyr Pro Tyr 
        275                 280                 285             


Asp Val Pro Asp Tyr Ala Ser 
    290                 295 


<210> 151
<211> 860
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 151
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Ala Gln Ala Ala Leu Glu Pro Gly Glu Lys Pro Tyr 
        35                  40                  45              


Ala Cys Pro Glu Cys Gly Lys Ser Phe Ser Asp Cys Arg Asp Leu Ala 
    50                  55                  60                  


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
65                  70                  75                  80  


Cys Gly Lys Ser Phe Ser Arg Ser Asp Asp Leu Val Arg His Gln Arg 
                85                  90                  95      


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly Lys Ser 
            100                 105                 110         


Phe Ser Gln Ser Ser Asn Leu Val Arg His Gln Arg Thr His Thr Gly 
        115                 120                 125             


Glu Lys Pro Tyr Ala Cys Pro Glu Cys Gly Lys Ser Phe Ser Thr Ser 
    130                 135                 140                 


Gly Glu Leu Val Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr 
145                 150                 155                 160 


Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Arg Ala His Leu Glu 
                165                 170                 175     


Arg His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Pro Glu 
            180                 185                 190         


Cys Gly Lys Ser Phe Ser Gln Ala Gly His Leu Ala Ser His Gln Arg 
        195                 200                 205             


Thr His Thr Gly Lys Lys Thr Ser Gly Gln Ala Gly Gln Ala Ser Pro 
    210                 215                 220                 


Lys Lys Lys Arg Lys Val Gly Arg Ala Ile Phe Lys Pro Glu Glu Leu 
225                 230                 235                 240 


Arg Gln Ala Leu Met Pro Thr Leu Glu Ala Leu Tyr Arg Gln Asp Pro 
                245                 250                 255     


Glu Ser Leu Pro Phe Arg Gln Pro Val Asp Pro Gln Leu Leu Gly Ile 
            260                 265                 270         


Pro Asp Tyr Phe Asp Ile Val Lys Ser Pro Met Asp Leu Ser Thr Ile 
        275                 280                 285             


Lys Arg Lys Leu Asp Thr Gly Gln Tyr Gln Glu Pro Trp Gln Tyr Val 
    290                 295                 300                 


Asp Asp Ile Trp Leu Met Phe Asn Asn Ala Trp Leu Tyr Asn Arg Lys 
305                 310                 315                 320 


Thr Ser Arg Val Tyr Lys Tyr Cys Ser Lys Leu Ser Glu Val Phe Glu 
                325                 330                 335     


Gln Glu Ile Asp Pro Val Met Gln Ser Leu Gly Tyr Cys Cys Gly Arg 
            340                 345                 350         


Lys Leu Glu Phe Ser Pro Gln Thr Leu Cys Cys Tyr Gly Lys Gln Leu 
        355                 360                 365             


Cys Thr Ile Pro Arg Asp Ala Thr Tyr Tyr Ser Tyr Gln Asn Arg Tyr 
    370                 375                 380                 


His Phe Cys Glu Lys Cys Phe Asn Glu Ile Gln Gly Glu Ser Val Ser 
385                 390                 395                 400 


Leu Gly Asp Asp Pro Ser Gln Pro Gln Thr Thr Ile Asn Lys Glu Gln 
                405                 410                 415     


Phe Ser Lys Arg Lys Asn Asp Thr Leu Asp Pro Glu Leu Phe Val Glu 
            420                 425                 430         


Cys Thr Glu Cys Gly Arg Lys Met His Gln Ile Cys Val Leu His His 
        435                 440                 445             


Glu Ile Ile Trp Pro Ala Gly Phe Val Cys Asp Gly Cys Leu Lys Lys 
    450                 455                 460                 


Ser Ala Arg Thr Arg Lys Glu Asn Lys Phe Ser Ala Lys Arg Leu Pro 
465                 470                 475                 480 


Ser Thr Arg Leu Gly Thr Phe Leu Glu Asn Arg Val Asn Asp Phe Leu 
                485                 490                 495     


Arg Arg Gln Asn His Pro Glu Ser Gly Glu Val Thr Val Arg Val Val 
            500                 505                 510         


His Ala Ser Asp Lys Thr Val Glu Val Lys Pro Gly Met Lys Ala Arg 
        515                 520                 525             


Phe Val Asp Ser Gly Glu Met Ala Glu Ser Phe Pro Tyr Arg Thr Lys 
    530                 535                 540                 


Ala Leu Phe Ala Phe Glu Glu Ile Asp Gly Val Asp Leu Cys Phe Phe 
545                 550                 555                 560 


Gly Met His Val Gln Glu Tyr Gly Ser Asp Cys Pro Pro Pro Asn Gln 
                565                 570                 575     


Arg Arg Val Tyr Ile Ser Tyr Leu Asp Ser Val His Phe Phe Arg Pro 
            580                 585                 590         


Lys Cys Leu Arg Thr Ala Val Tyr His Glu Ile Leu Ile Gly Tyr Leu 
        595                 600                 605             


Glu Tyr Val Lys Lys Leu Gly Tyr Thr Thr Gly His Ile Trp Ala Cys 
    610                 615                 620                 


Pro Pro Ser Glu Gly Asp Asp Tyr Ile Phe His Cys His Pro Pro Asp 
625                 630                 635                 640 


Gln Lys Ile Pro Lys Pro Lys Arg Leu Gln Glu Trp Tyr Lys Lys Met 
                645                 650                 655     


Leu Asp Lys Ala Val Ser Glu Arg Ile Val His Asp Tyr Lys Asp Ile 
            660                 665                 670         


Phe Lys Gln Ala Thr Glu Asp Arg Leu Thr Ser Ala Lys Glu Leu Pro 
        675                 680                 685             


Tyr Phe Glu Gly Asp Phe Trp Pro Asn Val Leu Glu Glu Ser Ile Lys 
    690                 695                 700                 


Glu Leu Glu Gln Glu Glu Glu Glu Arg Lys Arg Glu Glu Asn Thr Ser 
705                 710                 715                 720 


Asn Glu Ser Thr Asp Val Thr Lys Gly Asp Ser Lys Asn Ala Lys Lys 
                725                 730                 735     


Lys Asn Asn Lys Lys Thr Ser Lys Asn Lys Ser Ser Leu Ser Arg Gly 
            740                 745                 750         


Asn Lys Lys Lys Pro Gly Met Pro Asn Val Ser Asn Asp Leu Ser Gln 
        755                 760                 765             


Lys Leu Tyr Ala Thr Met Glu Lys His Lys Glu Val Phe Phe Val Ile 
    770                 775                 780                 


Arg Leu Ile Ala Gly Pro Ala Ala Asn Ser Leu Pro Pro Ile Val Asp 
785                 790                 795                 800 


Pro Asp Pro Leu Ile Pro Cys Asp Leu Met Asp Gly Arg Asp Ala Phe 
                805                 810                 815     


Leu Thr Leu Ala Arg Asp Lys His Leu Glu Phe Ser Ser Leu Arg Arg 
            820                 825                 830         


Ala Gln Trp Ser Thr Met Cys Met Leu Val Glu Leu His Thr Gln Ser 
        835                 840                 845             


Gln Asp Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser 
    850                 855                 860 


<210> 152
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 152
cctggtcttc aatgagaaga                                                   20


<210> 153
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 153
gattaggaca tgaacatggg                                                   20


<210> 154
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 154
cctcttctac attaacctta                                                   20


<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 155
tttttgaagc cagcaatcgt                                                   20


<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 156
cgttagtttc tggaggctct                                                   20


<210> 157
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 157
acaaattacc acgaatgtag                                                   20


<210> 158
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 158
tggcctgggc gcctgtctat                                                   20


<210> 159
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 159
attttgtaaa taaggtcttc                                                   20


<210> 160
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 160
agcaacaggg gatggggcag                                                   20


<210> 161
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 161
aggactcgta gtatgcaggc                                                   20


<210> 162
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 162
ctgagccacc aactatttaa                                                   20


<210> 163
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 163
ctgagccacc aactatttaa                                                   20


<210> 164
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 164
actctgggtc ggttacggaa                                                   20


<210> 165
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 165
gggctgggct tagcttggga                                                   20


<210> 166
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 166
atagggaggg gctctggagc                                                   20


<210> 167
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 167
atgggaaaag atacctgagt                                                   20


<210> 168
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 168
tgggagcgtt gtgtcgcagc                                                   20


<210> 169
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 169
tggaaaggct ttcattttct                                                   20


<210> 170
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 170
gtatctcgca gctccaatac                                                   20


<210> 171
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 171
acgcattccc ctcggtttga                                                   20


<210> 172
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 172
tcggaagctt ttcttctcag                                                   20


<210> 173
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 173
cgaaagggcg tgcgcgcccg                                                   20


<210> 174
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 174
ccggcgaaag ggaagcggcc                                                   20


<210> 175
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 175
ggctgcgcac gcccatcccc                                                   20


<210> 176
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 176
ggggcttgca ggtggttcgc                                                   20


<210> 177
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 177
cgagctaaag agcggatgcc                                                   20


<210> 178
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 178
agagggcggg agcagggcca                                                   20


<210> 179
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 179
aaccggctct taactctttg                                                   20


<210> 180
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 180
caggagcggc gagcggggtc                                                   20


<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 181
gggtatcaga tggcaaagtt                                                   20


<210> 182
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 182
tcataggctg ccggcgattg                                                   20


<210> 183
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 183
gaggttggcc aggagcagcg                                                   20


<210> 184
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 184
aattagcccc gcacggcgag                                                   20


<210> 185
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 185
tcccctgggt aggagtacag                                                   20


<210> 186
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 186
ggttgttagc tgcggtcagc                                                   20


<210> 187
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 187
ggtggagaac agggggcgcc                                                   20


<210> 188
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 188
cctggtcttc aatgagaaga ngg                                               23


<210> 189
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 189
gattaggaca tgaacatggg ngg                                               23


<210> 190
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 190
cctcttctac attaacctta ngg                                               23


<210> 191
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 191
tttttgaagc cagcaatcgt ngg                                               23


<210> 192
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 192
cgttagtttc tggaggctct ngg                                               23


<210> 193
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 193
acaaattacc acgaatgtag ngg                                               23


<210> 194
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 194
tggcctgggc gcctgtctat ngg                                               23


<210> 195
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 195
attttgtaaa taaggtcttc ngg                                               23


<210> 196
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 196
agcaacaggg gatggggcag ngg                                               23


<210> 197
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 197
aggactcgta gtatgcaggc ngg                                               23


<210> 198
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 198
ctgagccacc aactatttaa ngg                                               23


<210> 199
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 199
ctgagccacc aactatttaa ngg                                               23


<210> 200
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 200
actctgggtc ggttacggaa ngg                                               23


<210> 201
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 201
gggctgggct tagcttggga ngg                                               23


<210> 202
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 202
atagggaggg gctctggagc ngg                                               23


<210> 203
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 203
atgggaaaag atacctgagt ngg                                               23


<210> 204
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 204
tgggagcgtt gtgtcgcagc ngg                                               23


<210> 205
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 205
tggaaaggct ttcattttct ngg                                               23


<210> 206
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 206
gtatctcgca gctccaatac ngg                                               23


<210> 207
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 207
acgcattccc ctcggtttga ngg                                               23


<210> 208
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 208
tcggaagctt ttcttctcag ngg                                               23


<210> 209
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 209
cgaaagggcg tgcgcgcccg ngg                                               23


<210> 210
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 210
ccggcgaaag ggaagcggcc ngg                                               23


<210> 211
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 211
ggctgcgcac gcccatcccc ngg                                               23


<210> 212
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 212
ggggcttgca ggtggttcgc ngg                                               23


<210> 213
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 213
cgagctaaag agcggatgcc ngg                                               23


<210> 214
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 214
agagggcggg agcagggcca ngg                                               23


<210> 215
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 215
aaccggctct taactctttg ngg                                               23


<210> 216
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 216
caggagcggc gagcggggtc ngg                                               23


<210> 217
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 217
gggtatcaga tggcaaagtt ngg                                               23


<210> 218
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 218
tcataggctg ccggcgattg ngg                                               23


<210> 219
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 219
gaggttggcc aggagcagcg ngg                                               23


<210> 220
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 220
aattagcccc gcacggcgag ngg                                               23


<210> 221
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 221
tcccctgggt aggagtacag ngg                                               23


<210> 222
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 222
ggttgttagc tgcggtcagc ngg                                               23


<210> 223
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (21)..(21)
<223> a, c, t, g, unknown or other

<400> 223
ggtggagaac agggggcgcc ngg                                               23


<210> 224
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 224
gggggcgcga gtgatcagct                                                   20


<210> 225
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 225
cccgggtctc ctaggggacg                                                   20


<210> 226
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 226
tggtccggag aaagaaggcg                                                   20


<210> 227
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 227
gtctccgggc tcggaaactt                                                   20


<210> 228
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 228
agcgccagag cgcgagagcg                                                   20


<210> 229
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 229
cgattccggc cgcgttcccc                                                   20


<210> 230
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 230
gttgtgcggg ctgatgcgcc                                                   20


<210> 231
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 231
cctcgtgtgt tcctgggcct gctgc                                             25


<210> 232
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 232
tcccataaac aggattctgc tcaga                                             25


<210> 233
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 233
caccggccag atgacagaac agaaa                                             25


<210> 234
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 234
ttgtttgaaa atgccatttg tagggct                                           27


<210> 235
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 235
aaacgcagca ggcccaggaa cacac                                             25


<210> 236
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 236
aaactctgag cagaatcctg tttat                                             25


<210> 237
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 237
aaactttctg ttctgtcatc tggcc                                             25


<210> 238
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 238
aaacagccct acaaatggca ttttcaa                                           27


<210> 239
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 239
cctcgtctgc ttctgccgaa cctca                                             25


<210> 240
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 240
tcccacctaa agagcttgta ggccg                                             25


<210> 241
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 241
caccgagagc tggctacccg tccct                                             25


<210> 242
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 242
ttgtttgcgg tccttgttta tcagtag                                           27


<210> 243
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 243
aaactgaggt tcggcagaag cagac                                             25


<210> 244
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 244
aaaccggcct acaagctctt taggt                                             25


<210> 245
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 245
aaacagggac gggtagccag ctctc                                             25


<210> 246
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 246
aaacctactg ataaacaagg accgcaa                                           27


<210> 247
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 247
cctcggagct ggctacccgt cccta                                             25


<210> 248
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 248
tcccactttg gctgggttta aacca                                             25


<210> 249
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 249
caccggtcag ctcagggttt tggta                                             25


<210> 250
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 250
ttgtttggag ttagctcccc gacccag                                           27


<210> 251
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 251
aaactaggga cgggtagcca gctcc                                             25


<210> 252
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 252
aaactggttt aaacccagcc aaagt                                             25


<210> 253
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 253
aaactaccaa aaccctgagc tgacc                                             25


<210> 254
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 254
aaacctgggt cggggagcta actccaa                                           27


<210> 255
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 255
tgtgttcctg ggcctgctgc                                                   20


<210> 256
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 256
taaacaggat tctgctcaga                                                   20


<210> 257
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 257
gccagatgac agaacagaaa                                                   20


<210> 258
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 258
aaaatgccat ttgtagggct                                                   20


<210> 259
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 259
gcagcaggcc caggaacaca                                                   20


<210> 260
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 260
tctgagcaga atcctgttta                                                   20


<210> 261
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 261
tttctgttct gtcatctggc                                                   20


<210> 262
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 262
agccctacaa atggcatttt                                                   20


<210> 263
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 263
tctgcttctg ccgaacctca                                                   20


<210> 264
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 264
cctaaagagc ttgtaggccg                                                   20


<210> 265
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 265
agagctggct acccgtccct                                                   20


<210> 266
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 266
cggtccttgt ttatcagtag                                                   20


<210> 267
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 267
tgaggttcgg cagaagcaga                                                   20


<210> 268
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 268
cggcctacaa gctctttagg                                                   20


<210> 269
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 269
agggacgggt agccagctct                                                   20


<210> 270
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 270
ctactgataa acaaggaccg                                                   20


<210> 271
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 271
gagctggcta cccgtcccta                                                   20


<210> 272
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 272
ctttggctgg gtttaaacca                                                   20


<210> 273
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 273
gtcagctcag ggttttggta                                                   20


<210> 274
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 274
gagttagctc cccgacccag                                                   20


<210> 275
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 275
tagggacggg tagccagctc                                                   20


<210> 276
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 276
tggtttaaac ccagccaaag                                                   20


<210> 277
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 277
taccaaaacc ctgagctgac                                                   20


<210> 278
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 278
ctgggtcggg gagctaactc                                                   20


