                               SEQUENCE LISTING

<110> UNIVERSITY OF WASHINGTON
 
<120> PROLONGED ANTI-DIABETIC EFFECT OF FIBROBLAST GROWTH FACTOR 1 
      (FGF1) ADMINISTERED VIA THE INTRACEREBROVENTRICULAR (ICV) ROUTE

<130> 034186-086312-PCT

<140>
<141>

<150> 62/217,344
<151> 2015-09-11

<150> 62/114,451
<151> 2015-02-10

<160> 108   

<170> PatentIn version 3.5

<210> 1
<211> 155
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Glu Gly Glu Ile Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210> 2
<211> 131
<212> PRT
<213> Homo sapiens

<400> 2
Lys Pro Lys Leu Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile 
1               5                   10                  15      


Leu Pro Asp Gly Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His 
            20                  25                  30          


Ile Gln Leu Gln Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys 
        35                  40                  45              


Ser Thr Glu Thr Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu 
    50                  55                  60                  


Tyr Gly Ser Gln Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu 
65                  70                  75                  80  


Glu Glu Asn His Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys 
                85                  90                  95      


Asn Trp Phe Val Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro 
            100                 105                 110         


Arg Thr His Tyr Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val 
        115                 120                 125             


Ser Ser Asp 
    130     


<210> 3
<211> 127
<212> PRT
<213> Homo sapiens

<400> 3
Leu Tyr Cys Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly 
1               5                   10                  15      


Thr Val Asp Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln 
            20                  25                  30          


Leu Ser Ala Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr 
        35                  40                  45              


Gly Gln Tyr Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln 
    50                  55                  60                  


Thr Pro Asn Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His 
65                  70                  75                  80  


Tyr Asn Thr Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val 
                85                  90                  95      


Gly Leu Lys Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr 
            100                 105                 110         


Gly Gln Lys Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
        115                 120                 125         


<210> 4
<211> 155
<212> PRT
<213> Mus musculus

<400> 4
Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210> 5
<211> 155
<212> PRT
<213> Rattus norvegicus

<400> 5
Met Ala Glu Gly Glu Ile Thr Thr Phe Ala Ala Leu Thr Glu Arg Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala Glu 
    50                  55                  60                  


Ser Ala Gly Glu Val Tyr Ile Lys Gly Thr Glu Thr Gly Gln Tyr Leu 
65                  70                  75                  80  


Ala Met Asp Thr Glu Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Thr Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210> 6
<211> 155
<212> PRT
<213> Bos taurus

<400> 6
Met Ala Glu Gly Glu Thr Thr Thr Phe Thr Ala Leu Thr Glu Lys Phe 
1               5                   10                  15      


Asn Leu Pro Leu Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys Ser 
            20                  25                  30          


Asn Gly Gly Tyr Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp Gly 
        35                  40                  45              


Thr Lys Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Cys Ala Glu 
    50                  55                  60                  


Ser Ile Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Phe Leu 
65                  70                  75                  80  


Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn Glu 
                85                  90                  95      


Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr Tyr 
            100                 105                 110         


Ile Ser Lys Lys His Ala Glu Lys His Trp Phe Val Gly Leu Lys Lys 
        115                 120                 125             


Asn Gly Arg Ser Lys Leu Gly Pro Arg Thr His Phe Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
145                 150                 155 


<210> 7
<211> 288
<212> PRT
<213> Homo sapiens

<400> 7
Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210> 8
<211> 155
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210> 9
<211> 154
<212> PRT
<213> Mus musculus

<400> 9
Met Ala Ala Ser Gly Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ala Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210> 10
<211> 154
<212> PRT
<213> Rattus norvegicus

<400> 10
Met Ala Ala Gly Ser Ile Thr Ser Leu Pro Ala Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu Tyr 
            20                  25                  30          


Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg Val 
        35                  40                  45              


Asp Gly Val Arg Glu Lys Ser Asp Pro His Val Lys Leu Gln Leu Gln 
    50                  55                  60                  


Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn Arg 
65                  70                  75                  80  


Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys Val 
                85                  90                  95      


Thr Glu Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr Asn 
            100                 105                 110         


Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys Arg 
        115                 120                 125             


Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly Gln Lys Ala 
    130                 135                 140                 


Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 


<210> 11
<211> 155
<212> PRT
<213> Bos taurus

<400> 11
Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ser Leu Pro Glu Asp Gly 
1               5                   10                  15      


Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys Asp Pro Lys Arg Leu 
            20                  25                  30          


Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile His Pro Asp Gly Arg 
        35                  40                  45              


Val Asp Gly Val Arg Glu Lys Ser Asp Pro His Ile Lys Leu Gln Leu 
    50                  55                  60                  


Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys Gly Val Cys Ala Asn 
65                  70                  75                  80  


Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu Leu Ala Ser Lys Cys 
                85                  90                  95      


Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu Glu Ser Asn Asn Tyr 
            100                 105                 110         


Asn Thr Tyr Arg Ser Arg Lys Tyr Ser Ser Trp Tyr Val Ala Leu Lys 
        115                 120                 125             


Arg Thr Gly Gln Tyr Lys Leu Gly Pro Lys Thr Gly Pro Gly Gln Lys 
    130                 135                 140                 


Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
145                 150                 155 


<210> 12
<211> 239
<212> PRT
<213> Homo sapiens

<400> 12
Met Gly Leu Ile Trp Leu Leu Leu Leu Ser Leu Leu Glu Pro Gly Trp 
1               5                   10                  15      


Pro Ala Ala Gly Pro Gly Ala Arg Leu Arg Arg Asp Ala Gly Gly Arg 
            20                  25                  30          


Gly Gly Val Tyr Glu His Leu Gly Gly Ala Pro Arg Arg Arg Lys Leu 
        35                  40                  45              


Tyr Cys Ala Thr Lys Tyr His Leu Gln Leu His Pro Ser Gly Arg Val 
    50                  55                  60                  


Asn Gly Ser Leu Glu Asn Ser Ala Tyr Ser Ile Leu Glu Ile Thr Ala 
65                  70                  75                  80  


Val Glu Val Gly Ile Val Ala Ile Arg Gly Leu Phe Ser Gly Arg Tyr 
                85                  90                  95      


Leu Ala Met Asn Lys Arg Gly Arg Leu Tyr Ala Ser Glu His Tyr Ser 
            100                 105                 110         


Ala Glu Cys Glu Phe Val Glu Arg Ile His Glu Leu Gly Tyr Asn Thr 
        115                 120                 125             


Tyr Ala Ser Arg Leu Tyr Arg Thr Val Ser Ser Thr Pro Gly Ala Arg 
    130                 135                 140                 


Arg Gln Pro Ser Ala Glu Arg Leu Trp Tyr Val Ser Val Asn Gly Lys 
145                 150                 155                 160 


Gly Arg Pro Arg Arg Gly Phe Lys Thr Arg Arg Thr Gln Lys Ser Ser 
                165                 170                 175     


Leu Phe Leu Pro Arg Val Leu Asp His Arg Asp His Glu Met Val Arg 
            180                 185                 190         


Gln Leu Gln Ser Gly Leu Pro Arg Pro Pro Gly Lys Gly Val Gln Pro 
        195                 200                 205             


Arg Arg Arg Arg Gln Lys Gln Ser Pro Asp Asn Leu Glu Pro Ser His 
    210                 215                 220                 


Val Gln Ala Ser Arg Leu Gly Ser Gln Leu Glu Ala Ser Ala His 
225                 230                 235                 


<210> 13
<211> 245
<212> PRT
<213> Mus musculus

<400> 13
Met Gly Leu Ile Trp Leu Leu Leu Leu Ser Leu Leu Glu Pro Ser Trp 
1               5                   10                  15      


Pro Thr Thr Gly Pro Gly Thr Arg Leu Arg Arg Asp Ala Gly Gly Arg 
            20                  25                  30          


Gly Gly Val Tyr Glu His Leu Gly Gly Ala Pro Arg Arg Arg Lys Leu 
        35                  40                  45              


Tyr Cys Ala Thr Lys Tyr His Leu Gln Leu His Pro Ser Gly Arg Val 
    50                  55                  60                  


Asn Gly Ser Leu Glu Asn Ser Ala Tyr Ser Ile Leu Glu Ile Thr Ala 
65                  70                  75                  80  


Val Glu Val Gly Val Val Ala Ile Lys Gly Leu Phe Ser Gly Arg Tyr 
                85                  90                  95      


Leu Ala Met Asn Lys Arg Gly Arg Leu Tyr Ala Ser Asp His Tyr Asn 
            100                 105                 110         


Ala Glu Cys Glu Phe Val Glu Arg Ile His Glu Leu Gly Tyr Asn Thr 
        115                 120                 125             


Tyr Ala Ser Arg Leu Tyr Arg Thr Gly Ser Ser Gly Pro Gly Ala Gln 
    130                 135                 140                 


Arg Gln Pro Gly Ala Gln Arg Pro Trp Tyr Val Ser Val Asn Gly Lys 
145                 150                 155                 160 


Gly Arg Pro Arg Arg Gly Phe Lys Thr Arg Arg Thr Gln Lys Ser Ser 
                165                 170                 175     


Leu Phe Leu Pro Arg Val Leu Gly His Lys Asp His Glu Met Val Arg 
            180                 185                 190         


Leu Leu Gln Ser Ser Gln Pro Arg Ala Pro Gly Glu Gly Ser Gln Pro 
        195                 200                 205             


Arg Gln Arg Arg Gln Lys Lys Gln Ser Pro Ser Asp His Gly Lys Met 
    210                 215                 220                 


Glu Thr Leu Ser Thr Arg Ala Thr Pro Ser Thr Gln Leu His Thr Gly 
225                 230                 235                 240 


Gly Leu Ala Val Ala 
                245 


<210> 14
<211> 245
<212> PRT
<213> Rattus norvegicus

<400> 14
Met Gly Leu Ile Trp Leu Leu Leu Leu Ser Leu Leu Glu Pro Gly Trp 
1               5                   10                  15      


Pro Ala Thr Gly Pro Gly Thr Arg Leu Arg Arg Asp Ala Gly Gly Arg 
            20                  25                  30          


Gly Gly Val Tyr Glu His Leu Gly Gly Ala Pro Arg Arg Arg Lys Leu 
        35                  40                  45              


Tyr Cys Ala Thr Lys Tyr His Leu Gln Leu His Pro Ser Gly Arg Val 
    50                  55                  60                  


Asn Gly Ser Leu Glu Asn Ser Ala Tyr Ser Ile Leu Glu Ile Thr Ala 
65                  70                  75                  80  


Val Glu Val Gly Val Val Ala Ile Lys Gly Leu Phe Ser Gly Arg Tyr 
                85                  90                  95      


Leu Ala Met Asn Lys Arg Gly Arg Leu Tyr Ala Ser Glu His Tyr Asn 
            100                 105                 110         


Ala Glu Cys Glu Phe Val Glu Arg Ile His Glu Leu Gly Tyr Asn Thr 
        115                 120                 125             


Tyr Ala Ser Arg Leu Tyr Arg Thr Gly Pro Ser Gly Pro Gly Ala Arg 
    130                 135                 140                 


Arg Gln Pro Gly Ala Gln Arg Pro Trp Tyr Val Ser Val Asn Gly Lys 
145                 150                 155                 160 


Gly Arg Pro Arg Arg Gly Phe Lys Thr Arg Arg Thr Gln Lys Ser Ser 
                165                 170                 175     


Leu Phe Leu Pro Arg Val Leu Gly His Lys Asp His Glu Met Val Arg 
            180                 185                 190         


Leu Leu Gln Ser Gly Gln Pro Gln Ala Pro Gly Glu Gly Ser Gln Pro 
        195                 200                 205             


Arg Gln Arg Arg Gln Lys Lys Gln Ser Pro Gly Asp His Gly Lys Met 
    210                 215                 220                 


Glu His Leu Pro Thr Lys Ala Thr Thr Ser Ala Gln Leu Asp Thr Gly 
225                 230                 235                 240 


Gly Leu Ala Met Ala 
                245 


<210> 15
<211> 236
<212> PRT
<213> Bos taurus

<400> 15
Met Asp Leu Ile Trp Leu Leu Leu Leu Ser Leu Leu Glu Pro Gly Trp 
1               5                   10                  15      


Pro Ala Ala Gly Pro Val Ala Arg Pro Arg Arg Asp Ala Gly Gly Arg 
            20                  25                  30          


Gly Gly Val Tyr Glu His Leu Gly Gly Ala Pro Arg Arg Arg Lys Leu 
        35                  40                  45              


Tyr Cys Ala Thr Lys Tyr His Leu Gln Leu His Pro Ser Gly Arg Val 
    50                  55                  60                  


Asn Gly Ser Leu Glu Asn Ser Ala Tyr Ser Ile Leu Glu Ile Thr Ala 
65                  70                  75                  80  


Val Glu Val Gly Val Val Ala Ile Lys Gly Leu Phe Ser Gly Arg Tyr 
                85                  90                  95      


Leu Ala Met Asn Lys Arg Gly Arg Leu Tyr Ala Ser Glu Ser Tyr Asn 
            100                 105                 110         


Ala Glu Cys Glu Phe Val Glu Arg Ile His Glu Leu Gly Tyr Asn Thr 
        115                 120                 125             


Tyr Ala Ser Arg Leu Tyr Arg Thr Ala Pro Ser Gly Arg Gly Ala Arg 
    130                 135                 140                 


Arg Gln Pro Ser Ala Glu Arg Leu Trp Tyr Val Ser Val Asn Gly Lys 
145                 150                 155                 160 


Gly Arg Pro Arg Arg Gly Phe Lys Thr Arg Arg Thr Gln Lys Ser Ser 
                165                 170                 175     


Leu Phe Leu Pro Arg Val Leu Asp Arg Lys Asp His Glu Met Val Arg 
            180                 185                 190         


Leu Leu Leu Gly Thr Ala Gly Leu Arg Gly Gly Gln Ala Arg Pro Pro 
        195                 200                 205             


Pro Pro Gly Arg Ala Ala Ser Met Arg Gln Arg Arg Arg Arg Gln Gln 
    210                 215                 220                 


Arg Arg Pro Arg Asp Arg Asp Arg Gly Gly Arg Ala 
225                 230                 235     


<210> 16
<211> 206
<212> PRT
<213> Homo sapiens

<400> 16
Met Ser Gly Pro Gly Thr Ala Ala Val Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Leu Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Leu Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Ala Leu Pro Asp Gly Arg Ile Gly Gly Ala His Ala Asp Thr Arg 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Thr Phe Lys Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Tyr Lys Tyr Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Thr Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210> 17
<211> 202
<212> PRT
<213> Mus musculus

<400> 17
Met Ala Lys Arg Gly Pro Thr Thr Gly Thr Leu Leu Pro Arg Val Leu 
1               5                   10                  15      


Leu Ala Leu Val Val Ala Leu Ala Asp Arg Gly Thr Ala Ala Pro Asn 
            20                  25                  30          


Gly Thr Arg His Ala Glu Leu Gly His Gly Trp Asp Gly Leu Val Ala 
        35                  40                  45              


Arg Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro Pro Gln Ala Ala 
    50                  55                  60                  


Val Arg Ser Gly Ala Gly Asp Tyr Leu Leu Gly Leu Lys Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu Gln Val Leu Pro 
                85                  90                  95      


Asp Gly Arg Ile Gly Gly Val His Ala Asp Thr Arg Asp Ser Leu Leu 
            100                 105                 110         


Glu Leu Ser Pro Val Gln Arg Gly Val Val Ser Ile Phe Gly Val Ala 
        115                 120                 125             


Ser Arg Phe Phe Val Ala Met Ser Ser Arg Gly Lys Leu Phe Gly Val 
    130                 135                 140                 


Pro Phe Phe Thr Asp Glu Cys Lys Phe Lys Glu Ile Leu Leu Pro Asn 
145                 150                 155                 160 


Asn Tyr Asn Ala Tyr Glu Ser Tyr Ala Tyr Pro Gly Met Phe Met Ala 
                165                 170                 175     


Leu Ser Lys Asn Gly Arg Thr Lys Lys Gly Asn Arg Val Ser Pro Thr 
            180                 185                 190         


Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200         


<210> 18
<211> 195
<212> PRT
<213> Rattus norvegicus

<400> 18
Met Ala Lys Arg Gly Pro Thr Thr Gly Thr Leu Leu Pro Gly Val Leu 
1               5                   10                  15      


Leu Ala Leu Val Val Ala Leu Ala Asp Arg Gly Thr Ala Ala Pro Asn 
            20                  25                  30          


Gly Thr Arg His Ala Glu Leu Gly His Gly Trp Asp Gly Leu Val Ala 
        35                  40                  45              


Arg Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro Pro His Ala Ala 
    50                  55                  60                  


Val Arg Ser Gly Ala Gly Asp Tyr Leu Leu Gly Leu Lys Arg Leu Arg 
65                  70                  75                  80  


Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu Gln Val Leu Pro 
                85                  90                  95      


Asp Gly Arg Ile Gly Gly Val Pro Arg Gly His Glu Gly Gln Gln Arg 
            100                 105                 110         


Gly Val Val Ser Ile Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met 
        115                 120                 125             


Ser Ser Arg Gly Lys Leu Phe Gly Val Pro Phe Phe Thr Asp Glu Cys 
    130                 135                 140                 


Lys Phe Lys Glu Ile Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser 
145                 150                 155                 160 


Tyr Ala Tyr Pro Gly Met Phe Met Ala Leu Ser Lys Asn Gly Arg Thr 
                165                 170                 175     


Lys Lys Gly Asn Arg Val Ser Pro Thr Met Lys Val Thr His Phe Leu 
            180                 185                 190         


Pro Arg Leu 
        195 


<210> 19
<211> 206
<212> PRT
<213> Bos taurus

<400> 19
Met Ala Gly Pro Gly Ala Ala Ala Ala Ala Leu Leu Pro Ala Val Leu 
1               5                   10                  15      


Leu Ala Val Leu Ala Pro Trp Ala Gly Arg Gly Gly Ala Ala Ala Pro 
            20                  25                  30          


Thr Ala Pro Asn Gly Thr Leu Glu Ala Glu Leu Glu Arg Arg Trp Glu 
        35                  40                  45              


Ser Leu Val Ala Arg Ser Leu Ala Arg Leu Pro Val Ala Ala Gln Pro 
    50                  55                  60                  


Lys Glu Ala Ala Val Gln Ser Gly Ala Gly Asp Tyr Leu Leu Gly Ile 
65                  70                  75                  80  


Lys Arg Leu Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe His Leu 
                85                  90                  95      


Gln Val Leu Pro Asp Gly Arg Ile Gly Gly Val His Ala Asp Thr Ser 
            100                 105                 110         


Asp Ser Leu Leu Glu Leu Ser Pro Val Glu Arg Gly Val Val Ser Ile 
        115                 120                 125             


Phe Gly Val Ala Ser Arg Phe Phe Val Ala Met Ser Ser Arg Gly Arg 
    130                 135                 140                 


Leu Tyr Gly Ser Pro Phe Phe Thr Asp Glu Cys Arg Phe Arg Glu Ile 
145                 150                 155                 160 


Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Cys Asp Arg His Pro Gly 
                165                 170                 175     


Met Phe Ile Ala Leu Ser Lys Asn Gly Lys Ala Lys Lys Gly Asn Arg 
            180                 185                 190         


Val Ser Pro Thr Met Lys Val Thr His Phe Leu Pro Arg Leu 
        195                 200                 205     


<210> 20
<211> 268
<212> PRT
<213> Homo sapiens

<400> 20
Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Phe Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Asp Arg Asn Pro Arg Gly Ser Ser Ser Arg Gln 
        35                  40                  45              


Ser Ser Ser Ser Ala Met Ser Ser Ser Ser Ala Ser Ser Ser Pro Ala 
    50                  55                  60                  


Ala Ser Leu Gly Ser Gln Gly Ser Gly Leu Glu Gln Ser Ser Phe Gln 
65                  70                  75                  80  


Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly 
                85                  90                  95      


Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser 
            100                 105                 110         


His Glu Ala Asn Met Leu Ser Val Leu Glu Ile Phe Ala Val Ser Gln 
        115                 120                 125             


Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met 
    130                 135                 140                 


Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys 
145                 150                 155                 160 


Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser 
                165                 170                 175     


Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu 
            180                 185                 190         


Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro 
        195                 200                 205             


Gln His Ile Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln 
    210                 215                 220                 


Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro 
225                 230                 235                 240 


Ser Pro Ile Lys Pro Lys Ile Pro Leu Ser Ala Pro Arg Lys Asn Thr 
                245                 250                 255     


Asn Ser Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265             


<210> 21
<211> 264
<212> PRT
<213> Mus musculus

<400> 21
Met Ser Leu Ser Leu Leu Phe Leu Ile Phe Cys Ser His Leu Ile His 
1               5                   10                  15      


Ser Ala Trp Ala His Gly Glu Lys Arg Leu Thr Pro Glu Gly Gln Pro 
            20                  25                  30          


Ala Pro Pro Arg Asn Pro Gly Asp Ser Ser Gly Ser Arg Gly Arg Ser 
        35                  40                  45              


Ser Ala Thr Phe Ser Ser Ser Ser Ala Ser Ser Pro Val Ala Ala Ser 
    50                  55                  60                  


Pro Gly Ser Gln Gly Ser Gly Ser Glu His Ser Ser Phe Gln Trp Ser 
65                  70                  75                  80  


Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly Ile Gly 
                85                  90                  95      


Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser His Glu 
            100                 105                 110         


Ala Ser Val Leu Ser Ile Leu Glu Ile Phe Ala Val Ser Gln Gly Ile 
        115                 120                 125             


Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met Ser Lys 
    130                 135                 140                 


Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys Lys Phe 
145                 150                 155                 160 


Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser Ala Ile 
                165                 170                 175     


His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu Asn Lys 
            180                 185                 190         


Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro Gln His 
        195                 200                 205             


Val Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln Pro Glu 
    210                 215                 220                 


Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro Val Lys 
225                 230                 235                 240 


Pro Lys Val Pro Leu Ser Gln Pro Arg Arg Ser Pro Ser Pro Val Lys 
                245                 250                 255     


Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 


<210> 22
<211> 266
<212> PRT
<213> Rattus norvegicus

<400> 22
Met Ser Leu Ser Leu Leu Phe Leu Ile Phe Cys Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Pro Ala Gln Gly Glu Lys Arg Leu Thr Pro Glu Gly Gln Pro 
            20                  25                  30          


Ala Pro Pro Arg Asn Pro Gly Asp Ser Ser Gly Ser Arg Gly Arg Ser 
        35                  40                  45              


Ser Ala Thr Phe Ala Ser Ser Ser Ala Ser Ser Pro Val Ala Ala Ser 
    50                  55                  60                  


Pro Gly Ser Gln Gly Ser Gly Ser Glu His Ser Ser Phe Gln Trp Ser 
65                  70                  75                  80  


Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg Val Gly Ile Gly 
                85                  90                  95      


Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn Gly Ser His Glu 
            100                 105                 110         


Ala Ser Val Leu Ser Ile Leu Glu Ile Phe Ala Val Ser Gln Gly Ile 
        115                 120                 125             


Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu Ala Met Ser Lys 
    130                 135                 140                 


Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp Asp Cys Lys Phe 
145                 150                 155                 160 


Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr Ala Ser Ala Ile 
                165                 170                 175     


His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val Ala Leu Asn Lys 
            180                 185                 190         


Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val Lys Pro Gln His 
        195                 200                 205             


Val Ser Thr His Phe Leu Pro Arg Phe Lys Gln Ser Glu Gln Pro Glu 
    210                 215                 220                 


Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys Pro Pro Ser Pro 
225                 230                 235                 240 


Val Lys Pro Lys Val Pro Leu Ser Pro Pro Arg Arg Ser Pro Ser Pro 
                245                 250                 255     


Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265     


<210> 23
<211> 270
<212> PRT
<213> Bos taurus

<400> 23
Met Ser Leu Ser Phe Leu Leu Leu Leu Phe Leu Ser His Leu Ile Leu 
1               5                   10                  15      


Ser Ala Trp Ala Gln Gly Glu Lys Arg Leu Ala Pro Lys Gly Gln Pro 
            20                  25                  30          


Gly Pro Ala Ala Thr Glu Arg Asn Pro Gly Gly Ala Ser Ser Arg Arg 
        35                  40                  45              


Ser Ser Ser Ser Thr Ala Thr Ser Ser Ser Ser Pro Ala Ser Ser Ser 
    50                  55                  60                  


Ser Ala Ala Ser Arg Gly Gly Pro Gly Ser Ser Leu Glu Gln Ser Ser 
65                  70                  75                  80  


Phe Gln Trp Ser Pro Ser Gly Arg Arg Thr Gly Ser Leu Tyr Cys Arg 
                85                  90                  95      


Val Gly Ile Gly Phe His Leu Gln Ile Tyr Pro Asp Gly Lys Val Asn 
            100                 105                 110         


Gly Ser His Glu Ala Asn Met Leu Ser Ile Leu Glu Ile Phe Ala Val 
        115                 120                 125             


Ser Gln Gly Ile Val Gly Ile Arg Gly Val Phe Ser Asn Lys Phe Leu 
    130                 135                 140                 


Ala Met Ser Lys Lys Gly Lys Leu His Ala Ser Ala Lys Phe Thr Asp 
145                 150                 155                 160 


Asp Cys Lys Phe Arg Glu Arg Phe Gln Glu Asn Ser Tyr Asn Thr Tyr 
                165                 170                 175     


Ala Ser Ala Ile His Arg Thr Glu Lys Thr Gly Arg Glu Trp Tyr Val 
            180                 185                 190         


Ala Leu Asn Lys Arg Gly Lys Ala Lys Arg Gly Cys Ser Pro Arg Val 
        195                 200                 205             


Lys Pro Gln His Val Ser Thr His Phe Leu Pro Arg Phe Lys Gln Leu 
    210                 215                 220                 


Glu Gln Pro Glu Leu Ser Phe Thr Val Thr Val Pro Glu Lys Lys Lys 
225                 230                 235                 240 


Pro Pro Asn Pro Val Lys Pro Lys Val Pro Leu Ser Ala Pro Arg Arg 
                245                 250                 255     


Ser Pro Asn Thr Val Lys Tyr Arg Leu Lys Phe Arg Phe Gly 
            260                 265                 270 


<210> 24
<211> 208
<212> PRT
<213> Homo sapiens

<400> 24
Met Ala Leu Gly Gln Lys Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Leu Gln Gly Thr Leu Trp Ala Leu Val Phe Leu Gly Ile Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Asn Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Leu Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Arg Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Gln Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 25
<211> 208
<212> PRT
<213> Mus musculus

<400> 25
Met Ala Leu Gly Gln Arg Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Val Gln Gly Thr Leu Gln Ala Leu Val Phe Leu Gly Val Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Ala Arg Ala Asn Gly Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ser Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Pro Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Lys Ser Ala Leu Phe Ile Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Thr Thr Pro Ser Phe His Asp Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Arg Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 26
<211> 208
<212> PRT
<213> Rattus norvegicus

<400> 26
Met Ala Leu Gly Gln Arg Leu Phe Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Val Gln Gly Thr Leu Gln Ala Leu Val Phe Leu Gly Val Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Ala Arg Ala Asn Gly Thr Leu 
        35                  40                  45              


Leu Asp Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ser Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Pro Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Lys Ser Ala Leu Phe Ile Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Arg Leu Tyr Thr Thr Pro Ser Phe Gln Asp Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Arg Gly Thr Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Ile Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 27
<211> 208
<212> PRT
<213> Bos taurus

<400> 27
Met Ala Arg Gly Gln Thr Pro Leu Ile Thr Met Ser Arg Gly Ala Gly 
1               5                   10                  15      


Arg Pro Gln Gly Thr Leu Arg Ala Leu Val Phe Leu Gly Val Leu Val 
            20                  25                  30          


Gly Met Val Val Pro Ser Pro Ala Gly Thr Arg Ala Asn Gly Thr Leu 
        35                  40                  45              


Leu Ala Ser Arg Gly Trp Gly Thr Leu Leu Ser Arg Ser Arg Ala Gly 
    50                  55                  60                  


Leu Ala Gly Glu Ile Ala Gly Val Asn Trp Glu Ser Gly Tyr Leu Val 
65                  70                  75                  80  


Gly Ile Lys Arg Gln Arg Arg Leu Tyr Cys Asn Val Gly Ile Gly Phe 
                85                  90                  95      


His Leu Gln Val Pro Pro Asp Gly Arg Ile Ser Gly Thr His Glu Glu 
            100                 105                 110         


Asn Pro Tyr Ser Leu Leu Glu Ile Ser Thr Val Glu Arg Gly Val Val 
        115                 120                 125             


Ser Leu Phe Gly Val Lys Ser Ala Leu Phe Val Ala Met Asn Ser Lys 
    130                 135                 140                 


Gly Lys Leu Tyr Ala Thr Pro Ser Phe Gln Glu Glu Cys Lys Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Pro Asn Asn Tyr Asn Ala Tyr Glu Ser Asp Leu Tyr 
                165                 170                 175     


Arg Gly Ala Tyr Ile Ala Leu Ser Lys Tyr Gly Arg Val Lys Arg Gly 
            180                 185                 190         


Ser Lys Val Ser Pro Thr Met Thr Val Thr His Phe Leu Pro Arg Ile 
        195                 200                 205             


<210> 28
<211> 194
<212> PRT
<213> Homo sapiens

<400> 28
Met His Lys Trp Ile Leu Thr Trp Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210> 29
<211> 194
<212> PRT
<213> Mus musculus

<400> 29
Met Arg Lys Trp Ile Leu Thr Arg Ile Leu Pro Thr Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Leu Val Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Ser Pro Glu Gln Thr Ala Thr Ser Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Ser Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Tyr Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Ser Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Lys Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210> 30
<211> 194
<212> PRT
<213> Rattus norvegicus

<400> 30
Met Arg Lys Trp Ile Leu Thr Arg Ile Leu Pro Thr Pro Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Leu Val Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Ser Pro Glu Gln Thr Ala Thr Ser Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Arg Asn Ser Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Tyr Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Ser Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Leu Pro Val Lys Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210> 31
<211> 194
<212> PRT
<213> Bos taurus

<400> 31
Met Arg Lys Trp Ile Leu Thr Trp Ile Leu Pro Ser Leu Leu Tyr Arg 
1               5                   10                  15      


Ser Cys Phe His Ile Ile Cys Leu Val Gly Thr Ile Ser Leu Ala Cys 
            20                  25                  30          


Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser Ser 
        35                  40                  45              


Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp Ile 
    50                  55                  60                  


Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile Asp 
65                  70                  75                  80  


Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr Asn 
                85                  90                  95      


Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys Gly 
            100                 105                 110         


Val Glu Ser Glu Tyr Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu Tyr 
        115                 120                 125             


Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile Leu 
    130                 135                 140                 


Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Ser Gly 
145                 150                 155                 160 


Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Val Pro Val Arg Gly 
                165                 170                 175     


Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met Ala 
            180                 185                 190         


Ile Thr 
        


<210> 32
<211> 233
<212> PRT
<213> Homo sapiens

<400> 32
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Arg Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln His Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu 
    50                  55                  60                  


Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly 
65                  70                  75                  80  


Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu 
                85                  90                  95      


Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly 
            100                 105                 110         


Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met 
        115                 120                 125             


Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp 
    130                 135                 140                 


Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln 
145                 150                 155                 160 


Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg 
                165                 170                 175     


Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu Val His Phe 
            180                 185                 190         


Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln Ser Leu Arg 
        195                 200                 205             


Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser 
    210                 215                 220                 


Gln Arg Thr Trp Ala Pro Glu Pro Arg 
225                 230             


<210> 33
<211> 244
<212> PRT
<213> Mus musculus

<400> 33
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Gly Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Pro Thr Ser Leu Leu Arg Ala Gly Arg Glu Pro Gln Gly 
        35                  40                  45              


Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  


Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      


Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         


Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             


Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 


Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 


Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     


Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         


Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             


Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 


Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 


Pro Glu Pro Arg 
                


<210> 34
<211> 204
<212> PRT
<213> Rattus norvegicus

<400> 34
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln His Val Arg Glu Gln Ser Leu Val Thr 
            20                  25                  30          


Asp Gln Leu Ser Arg Arg Leu Ile Arg Thr Tyr Gln Leu Tyr Ser Arg 
        35                  40                  45              


Thr Ser Gly Lys His Val Gln Val Leu Ala Asn Lys Arg Ile Asn Ala 
    50                  55                  60                  


Met Ala Glu Asp Gly Asp Pro Phe Ala Lys Leu Ile Val Glu Thr Asp 
65                  70                  75                  80  


Thr Phe Gly Ser Arg Val Arg Val Arg Gly Ala Glu Thr Gly Leu Tyr 
                85                  90                  95      


Ile Cys Met Asn Lys Lys Gly Lys Leu Ile Ala Lys Ser Asn Gly Lys 
            100                 105                 110         


Gly Lys Asp Cys Val Phe Thr Glu Ile Val Leu Glu Asn Asn Tyr Thr 
        115                 120                 125             


Ala Leu Gln Asn Ala Lys Tyr Glu Gly Trp Tyr Met Ala Phe Thr Arg 
    130                 135                 140                 


Lys Gly Arg Pro Arg Lys Gly Ser Lys Thr Arg Gln His Gln Arg Glu 
145                 150                 155                 160 


Val His Phe Met Lys Arg Leu Pro Arg Gly His His Thr Thr Glu Gln 
                165                 170                 175     


Ser Leu Arg Phe Glu Phe Leu Asn Tyr Pro Pro Phe Thr Arg Ser Leu 
            180                 185                 190         


Arg Gly Ser Gln Arg Thr Trp Ala Pro Glu Pro Arg 
        195                 200                 


<210> 35
<211> 244
<212> PRT
<213> Bos taurus

<400> 35
Met Gly Ser Pro Arg Ser Ala Leu Ser Cys Leu Leu Leu His Leu Leu 
1               5                   10                  15      


Val Leu Cys Leu Gln Ala Gln Glu Gly Pro Gly Gly Gly Pro Ala Leu 
            20                  25                  30          


Gly Arg Glu Leu Ala Ser Leu Phe Arg Ala Gly Arg Glu Ser Gln Gly 
        35                  40                  45              


Val Ser Gln Gln Val Thr Val Gln Ser Ser Pro Asn Phe Thr Gln His 
    50                  55                  60                  


Val Arg Glu Gln Ser Leu Val Thr Asp Gln Leu Ser Arg Arg Leu Ile 
65                  70                  75                  80  


Arg Thr Tyr Gln Leu Tyr Ser Arg Thr Ser Gly Lys His Val Gln Val 
                85                  90                  95      


Leu Ala Asn Lys Arg Ile Asn Ala Met Ala Glu Asp Gly Asp Pro Phe 
            100                 105                 110         


Ala Lys Leu Ile Val Glu Thr Asp Thr Phe Gly Ser Arg Val Arg Val 
        115                 120                 125             


Arg Gly Ala Glu Thr Gly Leu Tyr Ile Cys Met Asn Lys Lys Gly Lys 
    130                 135                 140                 


Leu Ile Ala Lys Ser Asn Gly Lys Gly Lys Asp Cys Val Phe Thr Glu 
145                 150                 155                 160 


Ile Val Leu Glu Asn Asn Tyr Thr Ala Leu Gln Asn Ala Lys Tyr Glu 
                165                 170                 175     


Gly Trp Tyr Met Ala Phe Thr Arg Lys Gly Arg Pro Arg Lys Gly Ser 
            180                 185                 190         


Lys Thr Arg Gln His Gln Arg Glu Val His Phe Met Lys Arg Leu Pro 
        195                 200                 205             


Arg Gly His His Thr Thr Glu Gln Ser Leu Arg Phe Glu Phe Leu Asn 
    210                 215                 220                 


Tyr Pro Pro Phe Thr Arg Ser Leu Arg Gly Ser Gln Arg Thr Trp Ala 
225                 230                 235                 240 


Pro Glu Pro Arg 
                


<210> 36
<211> 208
<212> PRT
<213> Homo sapiens

<400> 36
Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210> 37
<211> 208
<212> PRT
<213> Mus musculus

<400> 37
Met Ala Pro Leu Gly Glu Val Gly Ser Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Cys Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210> 38
<211> 208
<212> PRT
<213> Rattus norvegicus

<400> 38
Met Ala Pro Leu Gly Glu Val Gly Ser Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Val Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Tyr Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210> 39
<211> 208
<212> PRT
<213> Bos taurus

<400> 39
Met Ala Pro Leu Gly Glu Val Gly Asn Tyr Phe Gly Val Gln Asp Ala 
1               5                   10                  15      


Val Pro Phe Gly Asn Gly Pro Val Leu Pro Val Asp Ser Pro Val Leu 
            20                  25                  30          


Leu Ser Asp His Leu Gly Gln Ser Glu Ala Gly Gly Leu Pro Arg Gly 
        35                  40                  45              


Pro Ala Val Thr Asp Leu Asp His Leu Lys Gly Ile Leu Arg Arg Arg 
    50                  55                  60                  


Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Glu Ile Phe Pro Asn Gly 
65                  70                  75                  80  


Thr Ile Gln Gly Thr Arg Lys Asp His Ser Arg Phe Gly Ile Leu Glu 
                85                  90                  95      


Phe Ile Ser Ile Ala Val Gly Leu Val Ser Ile Arg Gly Val Asp Ser 
            100                 105                 110         


Gly Leu Tyr Leu Gly Met Asn Glu Lys Gly Glu Leu Tyr Gly Ser Glu 
        115                 120                 125             


Lys Leu Thr Gln Glu Cys Val Phe Arg Glu Gln Phe Glu Glu Asn Trp 
    130                 135                 140                 


Tyr Asn Thr Tyr Ser Ser Asn Leu Tyr Lys His Val Asp Thr Gly Arg 
145                 150                 155                 160 


Arg Phe Tyr Val Ala Leu Asn Lys Asp Gly Thr Pro Arg Glu Gly Thr 
                165                 170                 175     


Arg Thr Lys Arg His Gln Lys Phe Thr His Phe Leu Pro Arg Pro Val 
            180                 185                 190         


Asp Pro Asp Lys Val Pro Glu Leu Tyr Lys Asp Ile Leu Ser Gln Ser 
        195                 200                 205             


<210> 40
<211> 208
<212> PRT
<213> Homo sapiens

<400> 40
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser 
            20                  25                  30          


Val Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu 
        35                  40                  45              


Ala Thr Asn Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala Gly 
    50                  55                  60                  


Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp Arg 
65                  70                  75                  80  


Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu Lys Ile Glu Lys Asn Gly 
                85                  90                  95      


Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro Tyr Ser Ile Leu Glu 
            100                 105                 110         


Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn Ser 
        115                 120                 125             


Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser Lys 
    130                 135                 140                 


Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn Gly 
145                 150                 155                 160 


Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln Met 
                165                 170                 175     


Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys Thr 
            180                 185                 190         


Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Val Val His Ser 
        195                 200                 205             


<210> 41
<211> 209
<212> PRT
<213> Mus musculus

<400> 41
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser Phe 
            20                  25                  30          


Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Gln Glu Ala 
        35                  40                  45              


Thr Asn Cys Ser Ser Ser Ser Ser Ser Phe Ser Ser Pro Ser Ser Ala 
    50                  55                  60                  


Gly Arg His Val Arg Ser Tyr Asn His Leu Gln Gly Asp Val Arg Trp 
65                  70                  75                  80  


Arg Arg Leu Phe Ser Phe Thr Lys Tyr Phe Leu Thr Ile Glu Lys Asn 
                85                  90                  95      


Gly Lys Val Ser Gly Thr Lys Asn Glu Asp Cys Pro Tyr Ser Val Leu 
            100                 105                 110         


Glu Ile Thr Ser Val Glu Ile Gly Val Val Ala Val Lys Ala Ile Asn 
        115                 120                 125             


Ser Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys Leu Tyr Gly Ser 
    130                 135                 140                 


Lys Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg Ile Glu Glu Asn 
145                 150                 155                 160 


Gly Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His Asn Gly Arg Gln 
                165                 170                 175     


Met Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg Arg Gly Gln Lys 
            180                 185                 190         


Thr Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro Met Thr Ile Gln 
        195                 200                 205             


Thr 
    


<210> 42
<211> 215
<212> PRT
<213> Rattus norvegicus

<400> 42
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Pro Gly Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser Val 
            20                  25                  30          


Pro Val Thr Cys Gln Ala Leu Gly Gln Asp Met Val Ser Pro Glu Ala 
        35                  40                  45              


Thr Asn Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Phe 
    50                  55                  60                  


Ser Ser Pro Ser Ser Ala Gly Arg His Val Arg Ser Tyr Asn His Leu 
65                  70                  75                  80  


Gln Gly Asp Val Arg Trp Arg Lys Leu Phe Ser Phe Thr Lys Tyr Phe 
                85                  90                  95      


Leu Lys Ile Glu Lys Asn Gly Lys Val Ser Gly Thr Lys Lys Glu Asn 
            100                 105                 110         


Cys Pro Tyr Ser Ile Leu Glu Ile Thr Ser Val Glu Ile Gly Val Val 
        115                 120                 125             


Ala Val Lys Ala Ile Asn Ser Asn Tyr Tyr Leu Ala Met Asn Lys Lys 
    130                 135                 140                 


Gly Lys Leu Tyr Gly Ser Lys Glu Phe Asn Asn Asp Cys Lys Leu Lys 
145                 150                 155                 160 


Glu Arg Ile Glu Glu Asn Gly Tyr Asn Thr Tyr Ala Ser Phe Asn Trp 
                165                 170                 175     


Gln His Asn Gly Arg Gln Met Tyr Val Ala Leu Asn Gly Lys Gly Ala 
            180                 185                 190         


Pro Arg Arg Gly Gln Lys Thr Arg Arg Lys Asn Thr Ser Ala His Phe 
        195                 200                 205             


Leu Pro Met Val Val His Ser 
    210                 215 


<210> 43
<211> 213
<212> PRT
<213> Bos taurus

<400> 43
Met Trp Lys Trp Ile Leu Thr His Cys Ala Ser Ala Phe Pro His Leu 
1               5                   10                  15      


Ser Gly Cys Cys Cys Cys Phe Leu Leu Leu Phe Leu Val Ser Ser Val 
            20                  25                  30          


Pro Val Thr Cys Gln Ala Leu Asp Gln Asp Met Val Ser Pro Gly Ala 
        35                  40                  45              


Thr Asn Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Val Ser 
    50                  55                  60                  


Leu Pro Ser Ser Ala Gly Arg His Val Arg Ser Tyr Asn His Leu Gln 
65                  70                  75                  80  


Gly Asp Val Arg Trp Arg Lys Leu Phe Ser Phe Thr Lys Tyr Phe Leu 
                85                  90                  95      


Lys Ile Glu Asn Gly Lys Val Ser Gly Thr Lys Lys Glu Asn Cys Pro 
            100                 105                 110         


Tyr Ser Ile Leu Glu Ile Thr Ser Val Glu Ile Gly Val Val Ala Val 
        115                 120                 125             


Lys Ala Ile Asn Ser Asn Tyr Tyr Leu Ala Met Asn Lys Lys Gly Lys 
    130                 135                 140                 


Leu Tyr Gly Ser Lys Glu Phe Asn Asn Asp Cys Lys Leu Lys Glu Arg 
145                 150                 155                 160 


Ile Glu Glu Asn Gly Tyr Asn Thr Tyr Ala Ser Phe Asn Trp Gln His 
                165                 170                 175     


Asn Gly Arg Gln Met Tyr Val Ala Leu Asn Gly Lys Gly Ala Pro Arg 
            180                 185                 190         


Arg Gly Gln Lys Thr Arg Arg Lys Asn Thr Ser Ala His Phe Leu Pro 
        195                 200                 205             


Met Val Val His Ser 
    210             


<210> 44
<211> 225
<212> PRT
<213> Homo sapiens

<400> 44
Met Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg 
1               5                   10                  15      


Glu Pro Gly Gly Ser Arg Pro Val Ser Ala Gln Arg Arg Val Cys Pro 
            20                  25                  30          


Arg Gly Thr Lys Ser Leu Cys Gln Lys Gln Leu Leu Ile Leu Leu Ser 
        35                  40                  45              


Lys Val Arg Leu Cys Gly Gly Arg Pro Ala Arg Pro Asp Arg Gly Pro 
    50                  55                  60                  


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Phe Cys Arg Gln Gly 
65                  70                  75                  80  


Phe Tyr Leu Gln Ala Asn Pro Asp Gly Ser Ile Gln Gly Thr Pro Glu 
                85                  90                  95      


Asp Thr Ser Ser Phe Thr His Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Thr Ile Gln Ser Ala Lys Leu Gly His Tyr Met Ala Met Asn 
        115                 120                 125             


Ala Glu Gly Leu Leu Tyr Ser Ser Pro His Phe Thr Ala Glu Cys Arg 
    130                 135                 140                 


Phe Lys Glu Cys Val Phe Glu Asn Tyr Tyr Val Leu Tyr Ala Ser Ala 
145                 150                 155                 160 


Leu Tyr Arg Gln Arg Arg Ser Gly Arg Ala Trp Tyr Leu Gly Leu Asp 
                165                 170                 175     


Lys Glu Gly Gln Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Ala 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Leu Leu Glu Val Ala Met Tyr Gln Glu 
        195                 200                 205             


Pro Ser Leu His Ser Val Pro Glu Ala Ser Pro Ser Ser Pro Pro Ala 
    210                 215                 220                 


Pro 
225 


<210> 45
<211> 197
<212> PRT
<213> Mus musculus

<400> 45
Met Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg 
1               5                   10                  15      


Glu Pro Gly Gly Ser Arg Pro Val Ser Ala Gln Arg Arg Val Cys Pro 
            20                  25                  30          


Arg Gly Thr Lys Ser Leu Cys Gln Lys Gln Leu Leu Ile Leu Leu Ser 
        35                  40                  45              


Lys Val Arg Leu Cys Gly Gly Arg Pro Thr Arg Gln Asp Arg Gly Pro 
    50                  55                  60                  


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Phe Cys Arg Gln Gly 
65                  70                  75                  80  


Phe Tyr Leu Gln Ala Asn Pro Asp Gly Ser Ile Gln Gly Thr Pro Glu 
                85                  90                  95      


Asp Thr Ser Ser Phe Thr His Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Thr Ile Gln Ser Ala Lys Leu Gly His Tyr Met Ala Met Asn 
        115                 120                 125             


Ala Glu Gly Leu Leu Tyr Ser Ser Arg Arg Ser Gly Arg Ala Trp Tyr 
    130                 135                 140                 


Leu Gly Leu Asp Lys Glu Gly Arg Val Met Lys Gly Asn Arg Val Lys 
145                 150                 155                 160 


Lys Thr Lys Ala Ala Ala His Phe Val Pro Lys Leu Leu Glu Val Ala 
                165                 170                 175     


Met Tyr Arg Glu Pro Ser Leu His Ser Val Pro Glu Thr Ser Pro Ser 
            180                 185                 190         


Ser Pro Pro Ala His 
        195         


<210> 46
<211> 225
<212> PRT
<213> Rattus norvegicus

<400> 46
Met Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg 
1               5                   10                  15      


Glu Pro Gly Gly Ser Arg Pro Val Ser Ala Gln Arg Arg Val Cys Pro 
            20                  25                  30          


Arg Gly Thr Lys Ser Leu Cys Gln Lys Gln Leu Leu Ile Leu Leu Ser 
        35                  40                  45              


Lys Val Arg Leu Cys Gly Gly Arg Pro Thr Arg Gln Asp Arg Gly Pro 
    50                  55                  60                  


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Phe Cys Arg Gln Gly 
65                  70                  75                  80  


Phe Tyr Leu Gln Ala Asn Pro Asp Gly Ser Ile Gln Gly Thr Pro Glu 
                85                  90                  95      


Asp Thr Ser Ser Phe Thr His Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Thr Ile Gln Ser Ala Lys Leu Gly His Tyr Met Ala Met Asn 
        115                 120                 125             


Ala Glu Gly Leu Leu Tyr Ser Ser Pro His Phe Thr Ala Glu Cys Arg 
    130                 135                 140                 


Phe Lys Glu Cys Val Phe Glu Asn Tyr Tyr Val Leu Tyr Ala Ser Ala 
145                 150                 155                 160 


Leu Tyr Arg Gln Arg Arg Ser Gly Arg Ala Trp Tyr Leu Gly Leu Asp 
                165                 170                 175     


Lys Glu Gly Arg Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Ala 
            180                 185                 190         


Ala Ala His Phe Val Pro Lys Leu Leu Glu Val Ala Val Tyr Arg Glu 
        195                 200                 205             


Pro Ser Leu His Ser Val Pro Glu Thr Ser Pro Ser Ser Pro Pro Ala 
    210                 215                 220                 


His 
225 


<210> 47
<211> 225
<212> PRT
<213> Bos taurus

<400> 47
Met Ala Ala Leu Ala Ser Ser Leu Ile Arg Gln Lys Arg Glu Val Arg 
1               5                   10                  15      


Glu Pro Gly Gly Ser Arg Pro Val Ser Ala Gln Arg Arg Val Cys Pro 
            20                  25                  30          


Arg Gly Thr Lys Ser Leu Cys Gln Lys Gln Leu Leu Ile Leu Leu Ser 
        35                  40                  45              


Lys Val Arg Leu Cys Gly Gly Arg Pro Ala Arg Thr Asp Arg Gly Pro 
    50                  55                  60                  


Glu Pro Gln Leu Lys Gly Ile Val Thr Lys Leu Phe Cys Arg Gln Gly 
65                  70                  75                  80  


Phe Tyr Leu Gln Ala Asn Pro Asp Gly Ser Ile Gln Gly Thr Pro Glu 
                85                  90                  95      


Asp Thr Ser Ser Phe Thr His Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Thr Ile Gln Ser Ala Lys Leu Gly His Tyr Met Ala Met Asn 
        115                 120                 125             


Ala Glu Gly Leu Leu Tyr Ser Ser Pro His Phe Thr Ala Glu Cys Arg 
    130                 135                 140                 


Phe Lys Glu Cys Val Phe Glu Asn Tyr Tyr Val Leu Tyr Ala Ser Ala 
145                 150                 155                 160 


Leu Tyr Arg Gln Arg Arg Ser Gly Arg Ala Trp Tyr Leu Gly Leu Asp 
                165                 170                 175     


Lys Glu Gly Arg Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Ala 
            180                 185                 190         


Ala Ala His Phe Val Pro Lys Leu Leu Glu Val Ala Met Tyr Arg Glu 
        195                 200                 205             


Pro Ser Leu His Ser Val Pro Glu Thr Ser Pro Ser Ser Pro Pro Ala 
    210                 215                 220                 


Pro 
225 


<210> 48
<211> 181
<212> PRT
<213> Homo sapiens

<400> 48
Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe 
1               5                   10                  15      


Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp 
            20                  25                  30          


Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro 
        35                  40                  45              


Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr 
    50                  55                  60                  


Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr 
65                  70                  75                  80  


Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile 
                85                  90                  95      


Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe 
            100                 105                 110         


Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys 
        115                 120                 125             


Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys 
    130                 135                 140                 


Met Tyr Arg Glu Gln Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val 
                165                 170                 175     


Asn Gln Asp Ser Thr 
            180     


<210> 49
<211> 181
<212> PRT
<213> Mus musculus

<400> 49
Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe 
1               5                   10                  15      


Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp 
            20                  25                  30          


Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro 
        35                  40                  45              


Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr 
    50                  55                  60                  


Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr 
65                  70                  75                  80  


Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile 
                85                  90                  95      


Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe 
            100                 105                 110         


Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys 
        115                 120                 125             


Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys 
    130                 135                 140                 


Met Tyr Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val 
                165                 170                 175     


Asn Gln Asp Ser Thr 
            180     


<210> 50
<211> 243
<212> PRT
<213> Rattus norvegicus


<220>
<221> MOD_RES
<222> (225)..(225)
<223> Any amino acid

<400> 50
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Ser Asn Ser Asp Arg Val Ser Ala Ser Lys Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asp Gly Arg Ser Leu Cys Glu Arg His Val Leu Gly Val 
        35                  40                  45              


Phe Ser Lys Val Arg Phe Cys Ser Gly Arg Lys Arg Pro Val Arg Arg 
    50                  55                  60                  


Arg Pro Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe Ser Gln 
65                  70                  75                  80  


Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp Gly Thr 
                85                  90                  95      


Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly 
            100                 105                 110         


Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr Val Ala 
        115                 120                 125             


Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr Pro Glu 
    130                 135                 140                 


Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser 
145                 150                 155                 160 


Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly 
                165                 170                 175     


Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys Lys Thr 
            180                 185                 190         


Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys Met Tyr 
        195                 200                 205             


Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg Ser Arg 
    210                 215                 220                 


Xaa Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val Asn Gln 
225                 230                 235                 240 


Asp Ser Thr 
            


<210> 51
<211> 181
<212> PRT
<213> Bos taurus

<400> 51
Met Glu Ser Lys Glu Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Phe 
1               5                   10                  15      


Ser Gln Gln Gly Tyr Phe Leu Gln Met His Pro Asp Gly Thr Ile Asp 
            20                  25                  30          


Gly Thr Lys Asp Glu Asn Ser Asp Tyr Thr Leu Phe Asn Leu Ile Pro 
        35                  40                  45              


Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Ala Ser Leu Tyr 
    50                  55                  60                  


Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Ser Ser Asp Val Phe Thr 
65                  70                  75                  80  


Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile 
                85                  90                  95      


Tyr Ser Ser Thr Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe 
            100                 105                 110         


Leu Gly Leu Asn Lys Glu Gly Gln Ile Met Lys Gly Asn Arg Val Lys 
        115                 120                 125             


Lys Thr Lys Pro Ser Ser His Phe Val Pro Lys Pro Ile Glu Val Cys 
    130                 135                 140                 


Met Tyr Arg Glu Pro Ser Leu His Glu Ile Gly Glu Lys Gln Gly Arg 
145                 150                 155                 160 


Ser Arg Lys Ser Ser Gly Thr Pro Thr Met Asn Gly Gly Lys Val Val 
                165                 170                 175     


Asn Gln Asp Ser Thr 
            180     


<210> 52
<211> 245
<212> PRT
<213> Homo sapiens

<400> 52
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu Leu Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210> 53
<211> 245
<212> PRT
<213> Mus musculus

<400> 53
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu His Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210> 54
<211> 245
<212> PRT
<213> Rattus norvegicus

<400> 54
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu His Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210> 55
<211> 245
<212> PRT
<213> Bos taurus

<400> 55
Met Ala Ala Ala Ile Ala Ser Ser Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Arg Glu Lys Ser Asn Ala Cys Lys Cys Val Ser Ser Pro Ser 
            20                  25                  30          


Lys Gly Lys Thr Ser Cys Asp Lys Asn Lys Leu Asn Val Phe Ser Arg 
        35                  40                  45              


Val Lys Leu Phe Gly Ser Lys Lys Arg Arg Arg Arg Arg Pro Glu Pro 
    50                  55                  60                  


Gln Leu Lys Gly Ile Val Thr Lys Leu Tyr Ser Arg Gln Gly Tyr His 
65                  70                  75                  80  


Leu Gln Leu Gln Ala Asp Gly Thr Ile Asp Gly Thr Lys Asp Glu Asp 
                85                  90                  95      


Ser Thr Tyr Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg Val Val 
            100                 105                 110         


Ala Ile Gln Gly Val Gln Thr Lys Leu Tyr Leu Ala Met Asn Ser Glu 
        115                 120                 125             


Gly Tyr Leu Tyr Thr Ser Glu His Phe Thr Pro Glu Cys Lys Phe Lys 
    130                 135                 140                 


Glu Ser Val Phe Glu Asn Tyr Tyr Val Thr Tyr Ser Ser Met Ile Tyr 
145                 150                 155                 160 


Arg Gln Gln Gln Ser Gly Arg Gly Trp Tyr Leu Gly Leu Asn Lys Glu 
                165                 170                 175     


Gly Glu Ile Met Lys Gly Asn His Val Lys Lys Asn Lys Pro Ala Ala 
            180                 185                 190         


His Phe Leu Pro Lys Pro Leu Lys Val Ala Met Tyr Lys Glu Pro Ser 
        195                 200                 205             


Leu His Asp Leu Thr Glu Phe Ser Arg Ser Gly Ser Gly Thr Pro Thr 
    210                 215                 220                 


Lys Ser Arg Ser Val Ser Gly Val Leu Asn Gly Gly Lys Ser Met Ser 
225                 230                 235                 240 


His Asn Glu Ser Thr 
                245 


<210> 56
<211> 252
<212> PRT
<213> Homo sapiens

<400> 56
Met Val Lys Pro Val Pro Leu Phe Arg Arg Thr Asp Phe Lys Leu Leu 
1               5                   10                  15      


Leu Cys Asn His Lys Asp Leu Phe Phe Leu Arg Val Ser Lys Leu Leu 
            20                  25                  30          


Asp Cys Phe Ser Pro Lys Ser Met Trp Phe Leu Trp Asn Ile Phe Ser 
        35                  40                  45              


Lys Gly Thr His Met Leu Gln Cys Leu Cys Gly Lys Ser Leu Lys Lys 
    50                  55                  60                  


Asn Lys Asn Pro Thr Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu 
65                  70                  75                  80  


Tyr Cys Arg Gln Gly Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu 
                85                  90                  95      


Asp Gly Thr Lys Asp Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile 
            100                 105                 110         


Pro Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu 
        115                 120                 125             


Tyr Ile Ala Met Asn Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe 
    130                 135                 140                 


Thr Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val 
145                 150                 155                 160 


Ile Tyr Ser Ser Met Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp 
                165                 170                 175     


Phe Leu Gly Leu Asn Lys Glu Gly Gln Ala Met Lys Gly Asn Arg Val 
            180                 185                 190         


Lys Lys Thr Lys Pro Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val 
        195                 200                 205             


Ala Met Tyr Arg Glu Pro Ser Leu His Asp Val Gly Glu Thr Val Pro 
    210                 215                 220                 


Lys Pro Gly Val Thr Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met 
225                 230                 235                 240 


Asn Gly Gly Lys Pro Val Asn Lys Ser Lys Thr Thr 
                245                 250         


<210> 57
<211> 247
<212> PRT
<213> Mus musculus

<400> 57
Met Ala Ala Ala Ile Ala Ser Gly Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Gln His Trp Asp Arg Pro Ser Ala Ser Arg Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asn Arg Gly Leu Cys Asn Gly Asn Leu Val Asp Ile Phe 
        35                  40                  45              


Ser Lys Val Arg Ile Phe Gly Leu Lys Lys Arg Arg Leu Arg Arg Gln 
    50                  55                  60                  


Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Tyr Cys Arg Gln Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu Asp Gly Thr Lys Asp 
                85                  90                  95      


Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu Tyr Ile Ala Met Asn 
        115                 120                 125             


Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe Thr Pro Glu Cys Lys 
    130                 135                 140                 


Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser Ser Met 
145                 150                 155                 160 


Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly Leu Asn 
                165                 170                 175     


Lys Glu Gly Gln Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Pro 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val Ala Met Tyr Arg Glu 
        195                 200                 205             


Pro Ser Leu His Asp Val Gly Glu Thr Val Pro Lys Ala Gly Val Thr 
    210                 215                 220                 


Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met Asn Gly Gly Lys Pro 
225                 230                 235                 240 


Val Asn Lys Cys Lys Thr Thr 
                245         


<210> 58
<211> 247
<212> PRT
<213> Rattus norvegicus

<400> 58
Met Ala Ala Ala Ile Ala Ser Gly Leu Ile Arg Gln Lys Arg Gln Ala 
1               5                   10                  15      


Arg Glu Gln His Trp Asp Arg Pro Ser Ala Ser Arg Arg Arg Ser Ser 
            20                  25                  30          


Pro Ser Lys Asn Arg Gly Leu Cys Asn Gly Asn Leu Val Asp Ile Phe 
        35                  40                  45              


Ser Lys Val Arg Ile Phe Gly Leu Lys Lys Arg Arg Leu Arg Arg Gln 
    50                  55                  60                  


Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu Tyr Cys Arg Gln Gly 
65                  70                  75                  80  


Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu Asp Gly Thr Lys Asp 
                85                  90                  95      


Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile Pro Val Gly Leu Arg 
            100                 105                 110         


Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu Tyr Ile Ala Met Asn 
        115                 120                 125             


Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe Thr Pro Glu Cys Lys 
    130                 135                 140                 


Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val Ile Tyr Ser Ser Met 
145                 150                 155                 160 


Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp Phe Leu Gly Leu Asn 
                165                 170                 175     


Lys Glu Gly Gln Val Met Lys Gly Asn Arg Val Lys Lys Thr Lys Pro 
            180                 185                 190         


Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val Ala Met Tyr Arg Glu 
        195                 200                 205             


Pro Ser Leu His Asp Val Gly Glu Thr Val Pro Lys Ala Gly Val Thr 
    210                 215                 220                 


Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met Asn Gly Gly Lys Pro 
225                 230                 235                 240 


Val Asn Lys Cys Lys Thr Thr 
                245         


<210> 59
<211> 252
<212> PRT
<213> Bos taurus

<400> 59
Met Val Lys Pro Val Pro Leu Phe Arg Arg Thr Asp Phe Lys Leu Leu 
1               5                   10                  15      


Leu Cys Asn His Lys Asp Leu Phe Phe Leu Arg Val Ser Lys Leu Leu 
            20                  25                  30          


Asp Cys Phe Ser Pro Lys Ser Met Trp Phe Leu Trp Asn Ile Phe Ser 
        35                  40                  45              


Lys Gly Thr His Met Leu Gln Cys Leu Cys Gly Lys Ser Leu Lys Lys 
    50                  55                  60                  


Asn Lys Asn Pro Thr Asp Pro Gln Leu Lys Gly Ile Val Thr Arg Leu 
65                  70                  75                  80  


Tyr Cys Arg Gln Gly Tyr Tyr Leu Gln Met His Pro Asp Gly Ala Leu 
                85                  90                  95      


Asp Gly Thr Lys Glu Asp Ser Thr Asn Ser Thr Leu Phe Asn Leu Ile 
            100                 105                 110         


Pro Val Gly Leu Arg Val Val Ala Ile Gln Gly Val Lys Thr Gly Leu 
        115                 120                 125             


Tyr Val Ala Met Asn Gly Glu Gly Tyr Leu Tyr Pro Ser Glu Leu Phe 
    130                 135                 140                 


Thr Pro Glu Cys Lys Phe Lys Glu Ser Val Phe Glu Asn Tyr Tyr Val 
145                 150                 155                 160 


Ile Tyr Ser Ser Met Leu Tyr Arg Gln Gln Glu Ser Gly Arg Ala Trp 
                165                 170                 175     


Phe Leu Gly Leu Asn Lys Glu Gly Gln Val Met Lys Gly Asn Arg Val 
            180                 185                 190         


Lys Lys Thr Lys Pro Ala Ala His Phe Leu Pro Lys Pro Leu Glu Val 
        195                 200                 205             


Ala Met Tyr Arg Glu Pro Ser Leu His Asp Val Gly Glu Thr Val Pro 
    210                 215                 220                 


Lys Ala Gly Val Thr Pro Ser Lys Ser Thr Ser Ala Ser Ala Ile Met 
225                 230                 235                 240 


Asn Gly Gly Lys Pro Val Asn Lys Ser Lys Thr Thr 
                245                 250         


<210> 60
<211> 218
<212> PRT
<213> Mus musculus

<400> 60
Met Ala Arg Lys Trp Asn Gly Arg Ala Val Ala Arg Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Leu Trp Leu Ala Val Ser Gly Arg Pro Leu Ala Gln Gln Ser 
            20                  25                  30          


Gln Ser Val Ser Asp Glu Asp Pro Leu Phe Leu Tyr Gly Trp Gly Lys 
        35                  40                  45              


Ile Thr Arg Leu Gln Tyr Leu Tyr Ser Ala Gly Pro Tyr Val Ser Asn 
    50                  55                  60                  


Cys Phe Leu Arg Ile Arg Ser Asp Gly Ser Val Asp Cys Glu Glu Asp 
65                  70                  75                  80  


Gln Asn Glu Arg Asn Leu Leu Glu Phe Arg Ala Val Ala Leu Lys Thr 
                85                  90                  95      


Ile Ala Ile Lys Asp Val Ser Ser Val Arg Tyr Leu Cys Met Ser Ala 
            100                 105                 110         


Asp Gly Lys Ile Tyr Gly Leu Ile Arg Tyr Ser Glu Glu Asp Cys Thr 
        115                 120                 125             


Phe Arg Glu Glu Met Asp Cys Leu Gly Tyr Asn Gln Tyr Arg Ser Met 
    130                 135                 140                 


Lys His His Leu His Ile Ile Phe Ile Gln Ala Lys Pro Arg Glu Gln 
145                 150                 155                 160 


Leu Gln Asp Gln Lys Pro Ser Asn Phe Ile Pro Val Phe His Arg Ser 
                165                 170                 175     


Phe Phe Glu Thr Gly Asp Gln Leu Arg Ser Lys Met Phe Ser Leu Pro 
            180                 185                 190         


Leu Glu Ser Asp Ser Met Asp Pro Phe Arg Met Val Glu Asp Val Asp 
        195                 200                 205             


His Leu Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215             


<210> 61
<211> 218
<212> PRT
<213> Rattus norvegicus

<400> 61
Met Ala Arg Lys Trp Ser Gly Arg Ile Val Ala Arg Ala Leu Val Leu 
1               5                   10                  15      


Ala Thr Leu Trp Leu Ala Val Ser Gly Arg Pro Leu Val Gln Gln Ser 
            20                  25                  30          


Gln Ser Val Ser Asp Glu Gly Pro Leu Phe Leu Tyr Gly Trp Gly Lys 
        35                  40                  45              


Ile Thr Arg Leu Gln Tyr Leu Tyr Ser Ala Gly Pro Tyr Val Ser Asn 
    50                  55                  60                  


Cys Phe Leu Arg Ile Arg Ser Asp Gly Ser Val Asp Cys Glu Glu Asp 
65                  70                  75                  80  


Gln Asn Glu Arg Asn Leu Leu Glu Phe Arg Ala Val Ala Leu Lys Thr 
                85                  90                  95      


Ile Ala Ile Lys Asp Val Ser Ser Val Arg Tyr Leu Cys Met Ser Ala 
            100                 105                 110         


Asp Gly Lys Ile Tyr Gly Leu Ile Arg Tyr Ser Glu Glu Asp Cys Thr 
        115                 120                 125             


Phe Arg Glu Glu Met Asp Cys Leu Gly Tyr Asn Gln Tyr Arg Ser Met 
    130                 135                 140                 


Lys His His Leu His Ile Ile Phe Ile Lys Ala Lys Pro Arg Glu Gln 
145                 150                 155                 160 


Leu Gln Gly Gln Lys Pro Ser Asn Phe Ile Pro Ile Phe His Arg Ser 
                165                 170                 175     


Phe Phe Glu Ser Thr Asp Gln Leu Arg Ser Lys Met Phe Ser Leu Pro 
            180                 185                 190         


Leu Glu Ser Asp Ser Met Asp Pro Phe Arg Met Val Glu Asp Val Asp 
        195                 200                 205             


His Leu Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215             


<210> 62
<211> 216
<212> PRT
<213> Homo sapiens

<400> 62
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210> 63
<211> 353
<212> PRT
<213> Bos taurus

<400> 63
Met Asn Ala Thr Glu Asp Ile Ser Glu Ser Ser Ser Ala Leu Arg Ser 
1               5                   10                  15      


Val Ile Thr Val Arg Cys Ser Pro Val Pro Ala Arg Arg Ala Pro Arg 
            20                  25                  30          


Glu Leu His Ala Gln Pro Leu Glu Lys Leu Ser Gly Thr Gln Gly Gln 
        35                  40                  45              


His Arg Arg Arg Lys Thr Gln Gln Lys Gln Arg Ser Leu Pro Ala Leu 
    50                  55                  60                  


Arg Ala Leu Glu Arg Thr Ala Ala Gly Arg Ala Arg Pro Ile Pro Gly 
65                  70                  75                  80  


Leu Lys Arg His Leu Ala Leu Ala Arg Ala Thr Leu Leu Phe Leu Arg 
                85                  90                  95      


Glu Pro Arg Ser Arg Leu Ala Pro Ser Arg Gly Thr Lys Ala Ser Gly 
            100                 105                 110         


Pro Pro Pro Ser Leu Pro His Pro His Arg Gln Ile Cys Ala Gln Ser 
        115                 120                 125             


Ser Glu Pro Glu Gly Gly Ala Met Arg Ser Ala Pro Ser Arg Cys Ala 
    130                 135                 140                 


Val Ala Arg Ala Leu Val Leu Ala Gly Leu Trp Leu Ala Ala Ala Gly 
145                 150                 155                 160 


Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Tyr Gly Trp 
                165                 170                 175     


Gly Glu Ser Val Arg Leu Arg His Leu Tyr Thr Ala Gly Pro Gln Gly 
            180                 185                 190         


Leu Tyr Ser Cys Phe Leu Arg Ile His Ser Asp Gly Ala Val Asp Cys 
        195                 200                 205             


Ala Gln Val Gln Ser Ala His Ser Leu Met Glu Ile Arg Ala Val Ala 
    210                 215                 220                 


Leu Ser Thr Val Ala Ile Lys Gly Glu Arg Ser Val Leu Tyr Leu Cys 
225                 230                 235                 240 


Met Asp Ala Asp Gly Lys Met Gln Gly Leu Thr Gln Tyr Ser Ala Glu 
                245                 250                 255     


Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr 
            260                 265                 270         


Trp Ser Arg Lys His His Leu Pro Val Ser Leu Ser Ser Ser Arg Gln 
        275                 280                 285             


Arg Gln Leu Phe Lys Ser Arg Gly Phe Leu Pro Leu Ser His Phe Leu 
    290                 295                 300                 


Pro Met Leu Ser Thr Ile Pro Ala Glu Pro Glu Asp Leu Gln Glu Pro 
305                 310                 315                 320 


Leu Lys Pro Asp Phe Phe Leu Pro Leu Lys Thr Asp Ser Met Asp Pro 
                325                 330                 335     


Phe Gly Leu Ala Thr Lys Leu Gly Ser Val Lys Ser Pro Ser Phe Tyr 
            340                 345                 350         


Asn 
    


<210> 64
<211> 211
<212> PRT
<213> Homo sapiens

<400> 64
Met Ala Pro Leu Ala Glu Val Gly Gly Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Ser Ala Ala Glu Arg Ser Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ala Ala Gln Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Thr 
    210     


<210> 65
<211> 212
<212> PRT
<213> Mus musculus

<400> 65
Met Ala Pro Leu Thr Glu Val Gly Ala Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Gly Ala Leu Glu Arg Gly Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ser Val Glu Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Thr Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asn 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg Arg Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Thr Gly 
    210         


<210> 66
<211> 212
<212> PRT
<213> Rattus norvegicus

<400> 66
Met Ala Pro Leu Thr Glu Val Gly Ala Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Gly Ala Leu Glu Arg Gly Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ser Val Glu Leu Ala His Leu His Gly Ile Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Gly Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Val Tyr Thr Gly 
    210         


<210> 67
<211> 211
<212> PRT
<213> Bos taurus

<400> 67
Met Ala Pro Leu Ala Glu Val Gly Gly Phe Leu Gly Gly Leu Glu Gly 
1               5                   10                  15      


Leu Gly Gln Gln Val Gly Ser His Phe Leu Leu Pro Pro Ala Gly Glu 
            20                  25                  30          


Arg Pro Pro Leu Leu Gly Glu Arg Arg Ser Ala Ala Glu Arg Gly Ala 
        35                  40                  45              


Arg Gly Gly Pro Gly Ala Ala Glu Leu Ala His Leu His Gly Phe Leu 
    50                  55                  60                  


Arg Arg Arg Gln Leu Tyr Cys Arg Thr Gly Phe His Leu Gln Ile Leu 
65                  70                  75                  80  


Pro Asp Gly Ser Val Gln Gly Thr Arg Gln Asp His Ser Leu Phe Gly 
                85                  90                  95      


Ile Leu Glu Phe Ile Ser Val Ala Val Gly Leu Val Ser Ile Arg Gly 
            100                 105                 110         


Val Asp Ser Gly Leu Tyr Leu Gly Met Asn Asp Lys Gly Glu Leu Tyr 
        115                 120                 125             


Gly Ser Glu Lys Leu Thr Ser Glu Cys Ile Phe Arg Glu Gln Phe Glu 
    130                 135                 140                 


Glu Asn Trp Tyr Asn Thr Tyr Ser Ser Asn Ile Tyr Lys His Gly Asp 
145                 150                 155                 160 


Thr Gly Arg Arg Tyr Phe Val Ala Leu Asn Lys Asp Gly Thr Pro Arg 
                165                 170                 175     


Asp Gly Ala Arg Ser Lys Arg His Gln Lys Phe Thr His Phe Leu Pro 
            180                 185                 190         


Arg Pro Val Asp Pro Glu Arg Val Pro Glu Leu Tyr Lys Asp Leu Leu 
        195                 200                 205             


Met Tyr Ser 
    210     


<210> 68
<211> 208
<212> PRT
<213> Homo sapiens

<400> 68
Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro Asp 
            20                  25                  30          


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
        35                  40                  45              


Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg Glu 
    50                  55                  60                  


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
65                  70                  75                  80  


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Lys 
                85                  90                  95      


Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
            100                 105                 110         


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
    130                 135                 140                 


Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 
145                 150                 155                 160 


Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu Pro 
                165                 170                 175     


Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
            180                 185                 190         


Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        195                 200                 205             


<210> 69
<211> 208
<212> PRT
<213> Rattus norvegicus

<400> 69
Met Asp Trp Met Lys Ser Arg Val Gly Ala Pro Gly Leu Trp Val Cys 
1               5                   10                  15      


Leu Leu Leu Pro Val Phe Leu Leu Gly Val Cys Glu Ala Tyr Pro Ile 
            20                  25                  30          


Ser Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
        35                  40                  45              


Tyr Leu Tyr Thr Asp Asp Asp Gln Asp Thr Glu Ala His Leu Glu Ile 
    50                  55                  60                  


Arg Glu Asp Gly Thr Val Val Gly Thr Ala His Arg Ser Pro Glu Ser 
65                  70                  75                  80  


Leu Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
                85                  90                  95      


Val Lys Ala Ser Arg Phe Leu Cys Gln Gln Pro Asp Gly Thr Leu Tyr 
            100                 105                 110         


Gly Ser Pro His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
        115                 120                 125             


Leu Lys Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
    130                 135                 140                 


Leu Arg Leu Pro Gln Lys Asp Ser Gln Asp Pro Ala Thr Arg Gly Pro 
145                 150                 155                 160 


Val Arg Phe Leu Pro Met Pro Gly Leu Pro His Glu Pro Gln Glu Gln 
                165                 170                 175     


Pro Gly Val Leu Pro Pro Glu Pro Pro Asp Val Gly Ser Ser Asp Pro 
            180                 185                 190         


Leu Ser Met Val Glu Pro Leu Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
        195                 200                 205             


<210> 70
<211> 209
<212> PRT
<213> Bos taurus

<400> 70
Met Gly Trp Asp Glu Ala Lys Phe Lys His Leu Gly Leu Trp Val Pro 
1               5                   10                  15      


Val Leu Ala Val Leu Leu Leu Gly Thr Cys Arg Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Glu Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Ala Asp Gly Thr Val Val Gly Ala Ala Arg Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Glu Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Gly Pro Asp Gly Lys Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Lys Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Thr Leu Gly Leu Pro Leu 
    130                 135                 140                 


Arg Leu Pro Pro Gln Arg Ser Ser Asn Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Ala Ala Pro Pro Asp 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Glu Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Tyr Gly Arg Ser Pro Ser Tyr Thr 
        195                 200                 205             


Ser 
    


<210> 71
<211> 170
<212> PRT
<213> Homo sapiens

<400> 71
Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Asp Ala Ala Gly Thr Pro Ser Ala Ser Arg Gly Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Arg Val Asp Pro Gly Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg His Gly Gln Asp Ser Ile Leu Glu Ile Arg Ser Val His 
65                  70                  75                  80  


Val Gly Val Val Val Ile Lys Ala Val Ser Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Arg Gly Arg Leu Tyr Gly Ser Arg Leu Tyr Thr Val Asp 
            100                 105                 110         


Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly His Asn Thr Tyr Ala 
        115                 120                 125             


Ser Gln Arg Trp Arg Arg Arg Gly Gln Pro Met Phe Leu Ala Leu Asp 
    130                 135                 140                 


Arg Arg Gly Gly Pro Arg Pro Gly Gly Arg Thr Arg Arg Tyr His Leu 
145                 150                 155                 160 


Ser Ala His Phe Leu Pro Val Leu Val Ser 
                165                 170 


<210> 72
<211> 126
<212> PRT
<213> Mus musculus

<400> 72
Met Arg Ser Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Gly Ala Pro Gly Gly Tyr Pro His Leu Glu Gly Asp Val Arg 
            20                  25                  30          


Trp Arg Arg Leu Phe Ser Ser Thr His Phe Phe Leu Arg Val Asp Leu 
        35                  40                  45              


Gly Gly Arg Val Gln Gly Thr Arg Trp Arg His Gly Gln Asp Ser Ile 
    50                  55                  60                  


Val Glu Ile Arg Ser Val Arg Val Gly Thr Val Val Ile Lys Ala Val 
65                  70                  75                  80  


Tyr Ser Gly Phe Tyr Val Ala Met Asn Arg Arg Gly Arg Leu Tyr Gly 
                85                  90                  95      


Ser Val Pro Gly Ala His Arg Gly Glu Arg Leu Gln His Ile Arg Leu 
            100                 105                 110         


Ala Thr Leu Glu Ala Pro Arg Pro Thr His Val Pro Gly Thr 
        115                 120                 125     


<210> 73
<211> 162
<212> PRT
<213> Rattus norvegicus

<400> 73
Met Arg Arg Arg Leu Trp Leu Gly Leu Ala Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Gly Ala Pro Gly Gly Tyr Pro His Leu Glu Gly Asp Val Arg 
            20                  25                  30          


Trp Arg Arg Leu Phe Ser Ser Thr His Phe Phe Leu Arg Val Asp Pro 
        35                  40                  45              


Gly Gly Arg Val Gln Gly Thr Arg Trp Arg His Gly Gln Asp Ser Ile 
    50                  55                  60                  


Val Glu Ile Arg Ser Val Arg Val Gly Thr Val Val Ile Lys Ala Val 
65                  70                  75                  80  


Tyr Ser Gly Phe Tyr Val Ala Met Asn Arg Arg Gly Arg Leu Tyr Gly 
                85                  90                  95      


Ser Arg Val Tyr Ser Val Asp Cys Arg Phe Arg Glu Arg Ile Glu Glu 
            100                 105                 110         


Asn Gly Tyr Asn Thr Tyr Ala Ser Arg Arg Trp Arg His His Gly Arg 
        115                 120                 125             


Pro Met Phe Leu Ala Leu Asp Ser Gln Gly Ile Pro Arg Gln Gly Arg 
    130                 135                 140                 


Arg Thr Arg Arg His Gln Leu Ser Thr His Phe Leu Pro Val Leu Val 
145                 150                 155                 160 


Ser Ser 
        


<210> 74
<211> 170
<212> PRT
<213> Bos taurus

<400> 74
Met Arg Gly Arg Leu Trp Leu Gly Leu Val Trp Leu Leu Leu Ala Arg 
1               5                   10                  15      


Ala Pro Gly Thr Ala Gly Thr Leu Asn Thr Pro Arg Arg Pro Arg Ser 
            20                  25                  30          


Tyr Pro His Leu Glu Gly Asp Val Arg Trp Arg Arg Leu Phe Ser Ser 
        35                  40                  45              


Thr His Phe Phe Leu Leu Val Asp Pro Ser Gly Arg Val Gln Gly Thr 
    50                  55                  60                  


Arg Trp Arg Asp Asn Pro Asp Ser Val Leu Glu Ile Arg Ser Ile Arg 
65                  70                  75                  80  


Val Gly Val Val Val Leu Lys Ala Val His Ser Gly Phe Tyr Val Ala 
                85                  90                  95      


Met Asn Arg Leu Gly Arg Leu Tyr Gly Ser Arg Phe Cys Ala Ala His 
            100                 105                 110         


Cys Arg Phe Arg Glu Arg Ile Glu Glu Asn Gly Tyr Asn Thr Tyr Ala 
        115                 120                 125             


Ser Val Arg Trp Arg His Gln Gly Arg Pro Met Phe Leu Ala Leu Asp 
    130                 135                 140                 


Gly Arg Gly Ala Pro Arg Leu Gly Gly Arg Thr Gln Arg His His Pro 
145                 150                 155                 160 


Ser Thr Leu Phe Leu Pro Val Leu Val Ser 
                165                 170 


<210> 75
<211> 251
<212> PRT
<213> Homo sapiens

<400> 75
Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210> 76
<211> 251
<212> PRT
<213> Mus musculus

<400> 76
Met Leu Gly Thr Cys Leu Arg Leu Leu Val Gly Val Leu Cys Thr Val 
1               5                   10                  15      


Cys Ser Leu Gly Thr Ala Arg Ala Tyr Pro Asp Thr Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Asn Trp Gly Ser Leu Thr His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Thr Ser Tyr His Leu Gln Ile His Arg Asp Gly His Val Asp Gly Thr 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Thr Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Ser Val Val Ile Thr Gly Ala Met Thr Arg Arg Phe Leu Cys Met 
                85                  90                  95      


Asp Leu His Gly Asn Ile Phe Gly Ser Leu His Phe Ser Pro Glu Asn 
            100                 105                 110         


Cys Lys Phe Arg Gln Trp Thr Leu Glu Asn Gly Tyr Asp Val Tyr Leu 
        115                 120                 125             


Ser Gln Lys His His Tyr Leu Val Ser Leu Gly Arg Ala Lys Arg Ile 
    130                 135                 140                 


Phe Gln Pro Gly Thr Asn Pro Pro Pro Phe Ser Gln Phe Leu Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Val Pro Leu Leu His Phe Tyr Thr Val Arg Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Pro Pro Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Pro Arg Ala Thr Pro Val Pro Val Ser Cys Ser Arg 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Glu Gly Gly Pro Ala Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Leu Arg Arg Gly Arg Gly Asp Ala Arg Gly Gly Ala Gly Gly 
225                 230                 235                 240 


Ala Asp Arg Cys Arg Pro Phe Pro Arg Phe Val 
                245                 250     


<210> 77
<211> 251
<212> PRT
<213> Rattus norvegicus

<400> 77
Met Leu Gly Ala Cys Leu Arg Leu Leu Val Gly Ala Leu Cys Thr Val 
1               5                   10                  15      


Cys Ser Leu Gly Thr Ala Arg Ala Tyr Ser Asp Thr Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Asn Trp Gly Ser Leu Thr His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Arg Asp Gly His Val Asp Gly Thr 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Thr Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Ser Val Val Ile Ile Gly Ala Met Thr Arg Arg Phe Leu Cys Met 
                85                  90                  95      


Asp Leu Arg Gly Asn Ile Phe Gly Ser Tyr His Phe Ser Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Arg Gln Trp Thr Leu Glu Asn Gly Tyr Asp Val Tyr Leu 
        115                 120                 125             


Ser Pro Lys His His Tyr Leu Val Ser Leu Gly Arg Ser Lys Arg Ile 
    130                 135                 140                 


Phe Gln Pro Gly Thr Asn Pro Pro Pro Phe Ser Gln Phe Leu Ala Arg 
145                 150                 155                 160 


Arg Asn Glu Val Pro Leu Leu His Phe Tyr Thr Ala Arg Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Pro Pro Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Pro Arg Ala Thr Pro Ile Pro Val Ser Cys Ser Arg 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Glu Gly Gly Pro Ala Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Leu Arg Arg Gly Arg Gly Asp Ala Arg Arg Gly Ala Gly Gly 
225                 230                 235                 240 


Thr Asp Arg Cys Arg Pro Phe Pro Arg Phe Val 
                245                 250     


<210> 78
<211> 245
<212> PRT
<213> Bos taurus

<400> 78
Met Leu Gly Ala Arg Leu Gly Leu Trp Val Cys Thr Leu Ser Cys Val 
1               5                   10                  15      


Val Gln Ala Tyr Pro Asn Ser Ser Pro Leu Leu Gly Ser Ser Trp Gly 
            20                  25                  30          


Gly Leu Thr His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu 
        35                  40                  45              


Gln Ile His Gly Asp Gly His Val Asp Gly Ser Pro Gln Gln Thr Val 
    50                  55                  60                  


Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala Gly Phe Val Val Ile 
65                  70                  75                  80  


Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met Asp Phe Thr Gly Asn 
                85                  90                  95      


Ile Phe Gly Ser His His Phe Ser Pro Glu Ser Cys Arg Phe Arg Gln 
            100                 105                 110         


Arg Thr Leu Glu Asn Gly Tyr Asp Val Tyr His Ser Pro Gln His Arg 
        115                 120                 125             


Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala Phe Leu Pro Gly Thr 
    130                 135                 140                 


Asn Pro Pro Pro Tyr Ala Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro 
145                 150                 155                 160 


Leu Pro His Phe Ala Ala Thr Ala Arg Pro Arg Arg His Thr Arg Ser 
                165                 170                 175     


Ala His Asp Ser Gly Asp Pro Leu Ser Val Leu Lys Pro Arg Ala Arg 
            180                 185                 190         


Ala Thr Pro Val Pro Ala Ala Cys Ser Gln Glu Leu Pro Ser Ala Glu 
        195                 200                 205             


Asp Ser Gly Pro Ala Ala Ser Asp Pro Leu Gly Val Leu Arg Gly His 
    210                 215                 220                 


Arg Leu Asp Val Arg Ala Gly Ser Ala Gly Ala Glu Arg Cys Arg Pro 
225                 230                 235                 240 


Phe Pro Gly Phe Ala 
                245 


<210> 79
<211> 820
<212> PRT
<213> Homo sapiens

<400> 79
Met Trp Ser Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ser Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Phe Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Gln Asp Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Met Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Val Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210> 80
<211> 820
<212> PRT
<213> Mus musculus

<400> 80
Met Trp Gly Trp Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Val Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Val Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Arg Asp Ser Ile Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 


Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     


Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         


Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             


Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 


Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         


Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 


Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             


Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 


Ile Ser Cys Met Leu Gly Ser Val Ile Ile Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Ile Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Thr Gln Leu Ala Asn Ser Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210> 81
<211> 822
<212> PRT
<213> Rattus norvegicus

<400> 81
Met Trp Gly Trp Arg Gly Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Arg Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Val Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Glu Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Arg Asp Ser Ile Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Asn Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Arg Arg Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys 
145                 150                 155                 160 


Met Glu Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe 
                165                 170                 175     


Lys Cys Pro Ser Ser Gly Thr Pro Ser Pro Thr Leu Arg Trp Leu Lys 
            180                 185                 190         


Asn Gly Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val 
        195                 200                 205             


Arg Tyr Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp 
    210                 215                 220                 


Lys Gly Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn 
225                 230                 235                 240 


His Thr Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile 
                245                 250                 255     


Leu Gln Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn 
            260                 265                 270         


Val Glu Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln 
        275                 280                 285             


Trp Leu Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn 
    290                 295                 300                 


Leu Pro Tyr Asp Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp 
305                 310                 315                 320 


Lys Glu Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala 
                325                 330                 335     


Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His 
            340                 345                 350         


Ser Ala Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val 
        355                 360                 365             


Met Thr Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala 
    370                 375                 380                 


Phe Leu Ile Ser Cys Met Val Gly Ser Val Ile Ile Tyr Lys Met Lys 
385                 390                 395                 400 


Ser Gly Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys 
                405                 410                 415     


Leu Ala Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp 
            420                 425                 430         


Ser Ser Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg 
        435                 440                 445             


Leu Ser Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu 
    450                 455                 460                 


Leu Pro Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu 
465                 470                 475                 480 


Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu 
                485                 490                 495     


Ala Ile Gly Leu Asp Lys Asp Lys Pro Asn Arg Val Thr Lys Val Ala 
            500                 505                 510         


Val Lys Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu 
        515                 520                 525             


Ile Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile 
    530                 535                 540                 


Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile 
545                 550                 555                 560 


Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg 
                565                 570                 575     


Arg Pro Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His Asn Pro Glu 
            580                 585                 590         


Glu Gln Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala 
        595                 600                 605             


Arg Gly Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu 
    610                 615                 620                 


Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala 
625                 630                 635                 640 


Asp Phe Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys 
                645                 650                 655     


Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu 
            660                 665                 670         


Phe Asp Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val 
        675                 680                 685             


Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Asn Pro Gly Val 
    690                 695                 700                 


Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp 
705                 710                 715                 720 


Lys Pro Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys 
                725                 730                 735     


Trp Asn Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu 
            740                 745                 750         


Asp Leu Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp 
        755                 760                 765             


Leu Ser Met Pro Leu Asp Gln Asp Ser Pro Ser Phe Pro Asp Thr Arg 
    770                 775                 780                 


Ser Ser Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro 
785                 790                 795                 800 


Phe Pro Glu Glu Pro Cys Leu Pro Arg His Pro Thr Gln Leu Ala Asn 
                805                 810                 815     


Gly Gly Leu Asn Arg Arg 
            820         


<210> 82
<211> 820
<212> PRT
<213> Bos taurus

<400> 82
Met Trp Ser Arg Lys Cys Leu Leu Phe Trp Ala Val Leu Val Thr Ala 
1               5                   10                  15      


Thr Leu Cys Thr Ala Lys Pro Ala Pro Thr Leu Pro Glu Gln Ala Gln 
            20                  25                  30          


Pro Trp Gly Ala Pro Val Glu Val Glu Ser Leu Leu Val His Pro Gly 
        35                  40                  45              


Asp Leu Leu Gln Leu Arg Cys Arg Leu Arg Asp Asp Val Gln Ser Ile 
    50                  55                  60                  


Asn Trp Leu Arg Asp Gly Val Gln Leu Ala Asp Ser Asn Arg Thr Arg 
65                  70                  75                  80  


Ile Thr Gly Glu Glu Val Glu Val Arg Gly Ser Val Pro Ala Asp Ser 
                85                  90                  95      


Gly Leu Tyr Ala Cys Val Thr Ser Ser Pro Ser Gly Ser Asp Thr Thr 
            100                 105                 110         


Tyr Phe Ser Val Asn Val Ser Asp Ala Leu Pro Ser Ser Glu Asp Asp 
        115                 120                 125             


Asp Asp Asp Asp Asp Ser Ser Ser Glu Glu Lys Glu Thr Asp Asn Thr 
    130                 135                 140                 


Lys Pro Asn Pro Val Ala Pro Tyr Trp Thr Ser Pro Glu Lys Met Glu 
145                 150                 155                 160 


Lys Lys Leu His Ala Val Pro Ala Ala Lys Thr Val Lys Phe Lys Cys 
                165                 170                 175     


Pro Ser Ser Gly Thr Pro Asn Pro Thr Leu Arg Trp Leu Lys Asn Gly 
            180                 185                 190         


Lys Glu Phe Lys Pro Asp His Arg Ile Gly Gly Tyr Lys Val Arg Tyr 
        195                 200                 205             


Ala Thr Trp Ser Ile Ile Met Asp Ser Val Val Pro Ser Asp Lys Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Ile Val Glu Asn Glu Tyr Gly Ser Ile Asn His Thr 
225                 230                 235                 240 


Tyr Gln Leu Asp Val Val Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Lys Thr Val Ala Leu Gly Ser Asn Val Glu 
            260                 265                 270         


Phe Met Cys Lys Val Tyr Ser Asp Pro Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Ile Glu Val Asn Gly Ser Lys Ile Gly Pro Asp Asn Leu Pro 
    290                 295                 300                 


Tyr Val Gln Ile Leu Lys Thr Ala Gly Val Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Met Glu Val Leu His Leu Arg Asn Val Ser Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Leu Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Thr Val Leu Glu Ala Leu Glu Glu Arg Pro Ala Val Met Thr 
        355                 360                 365             


Ser Pro Leu Tyr Leu Glu Ile Ile Ile Tyr Cys Thr Gly Ala Phe Leu 
    370                 375                 380                 


Ile Ser Cys Met Val Gly Ser Val Ile Ile Tyr Lys Met Lys Ser Gly 
385                 390                 395                 400 


Thr Lys Lys Ser Asp Phe His Ser Gln Met Ala Val His Lys Leu Ala 
                405                 410                 415     


Lys Ser Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala Asp Ser Ser 
            420                 425                 430         


Ala Ser Met Asn Ser Gly Val Leu Leu Val Arg Pro Ser Arg Leu Ser 
        435                 440                 445             


Ser Ser Gly Thr Pro Met Leu Ala Gly Val Ser Glu Tyr Glu Leu Pro 
    450                 455                 460                 


Glu Asp Pro Arg Trp Glu Leu Pro Arg Asp Arg Leu Val Leu Gly Lys 
465                 470                 475                 480 


Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Leu Ala Glu Ala Ile 
                485                 490                 495     


Gly Leu Asp Lys Asp Arg Pro Asn Arg Val Thr Lys Val Ala Val Lys 
            500                 505                 510         


Met Leu Lys Ser Asp Ala Thr Glu Lys Asp Leu Ser Asp Leu Ile Ser 
        515                 520                 525             


Glu Met Glu Met Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn 
    530                 535                 540                 


Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu Tyr Val Ile Val Glu 
545                 550                 555                 560 


Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu Gln Ala Arg Arg Pro 
                565                 570                 575     


Pro Gly Leu Glu Tyr Cys Tyr Asn Pro Ser His His Pro Glu Glu Gln 
            580                 585                 590         


Leu Ser Ser Lys Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly 
        595                 600                 605             


Met Glu Tyr Leu Ala Ser Lys Lys Cys Ile His Arg Asp Leu Ala Ala 
    610                 615                 620                 


Arg Asn Val Leu Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe 
625                 630                 635                 640 


Gly Leu Ala Arg Asp Ile His His Ile Asp Tyr Tyr Lys Lys Thr Thr 
                645                 650                 655     


Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp 
            660                 665                 670         


Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu 
        675                 680                 685             


Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro Gly Val Pro Val 
    690                 695                 700                 


Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro 
705                 710                 715                 720 


Ser Asn Cys Thr Asn Glu Leu Tyr Met Met Met Arg Asp Cys Trp His 
                725                 730                 735     


Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu 
            740                 745                 750         


Asp Arg Ile Val Ala Leu Thr Ser Asn Gln Glu Tyr Leu Asp Leu Ser 
        755                 760                 765             


Met Pro Leu Asp Gln Tyr Ser Pro Ser Phe Pro Asp Thr Arg Ser Ser 
    770                 775                 780                 


Thr Cys Ser Ser Gly Glu Asp Ser Val Phe Ser His Glu Pro Leu Pro 
785                 790                 795                 800 


Glu Glu Pro Cys Leu Pro Arg His Pro Ala Gln Leu Ala Asn Gly Gly 
                805                 810                 815     


Leu Lys Arg Arg 
            820 


<210> 83
<211> 821
<212> PRT
<213> Homo sapiens

<400> 83
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Val Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Val Tyr Val Ala Ala Pro Gly Glu Ser Leu Glu Val Arg Cys Leu Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ser Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Tyr Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Gly Ala Glu Asp Phe Val 
    130                 135                 140                 


Ser Glu Asn Ser Asn Asn Lys Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Met Pro Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Gly Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Leu Cys Arg Met 
385                 390                 395                 400 


Lys Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Ser Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210> 84
<211> 821
<212> PRT
<213> Mus musculus

<400> 84
Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Leu Val Thr Met Ala 
1               5                   10                  15      


Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu Asp Thr Thr 
            20                  25                  30          


Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser Gln Pro Glu 
        35                  40                  45              


Ala Tyr Val Val Ala Pro Gly Glu Ser Leu Glu Leu Gln Cys Met Leu 
    50                  55                  60                  


Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val His Leu Gly 
65                  70                  75                  80  


Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln Ile Lys Gly 
                85                  90                  95      


Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala Ala Arg Thr 
            100                 105                 110         


Val Asp Ser Glu Thr Trp Ile Phe Met Val Asn Val Thr Asp Ala Ile 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Ser Ser Glu Asp Val Val 
    130                 135                 140                 


Ser Glu Asn Arg Ser Asn Gln Arg Ala Pro Tyr Trp Thr Asn Thr Glu 
145                 150                 155                 160 


Lys Met Glu Lys Arg Leu His Ala Cys Pro Ala Ala Asn Thr Val Lys 
                165                 170                 175     


Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Ser Thr Met Arg Trp Leu 
            180                 185                 190         


Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly Gly Tyr Lys 
        195                 200                 205             


Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val Val Pro Ser 
    210                 215                 220                 


Asp Lys Gly Asn Tyr Thr Cys Leu Val Glu Asn Glu Tyr Gly Ser Ile 
225                 230                 235                 240 


Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro His Arg Pro 
                245                 250                 255     


Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val Val Gly Gly 
            260                 265                 270         


Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile 
        275                 280                 285             


Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Asn Gly Pro Asp 
    290                 295                 300                 


Gly Leu Pro Tyr Leu Lys Val Leu Lys Ala Ala Gly Val Asn Thr Thr 
305                 310                 315                 320 


Asp Lys Glu Ile Glu Val Leu Tyr Ile Arg Asn Val Thr Phe Glu Asp 
                325                 330                 335     


Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Ile Ser Phe 
            340                 345                 350         


His Ser Ala Trp Leu Thr Val Leu Pro Ala Pro Val Arg Glu Lys Glu 
        355                 360                 365             


Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile Tyr Cys Ile Gly 
    370                 375                 380                 


Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile Phe Cys Arg Met 
385                 390                 395                 400 


Lys Thr Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln Pro Ala Val His 
                405                 410                 415     


Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val Thr Val Ser Ala 
            420                 425                 430         


Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg Ile Thr 
        435                 440                 445             


Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly Val Ser 
    450                 455                 460                 


Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg Asp Lys 
465                 470                 475                 480 


Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
                485                 490                 495     


Met Ala Glu Ala Val Gly Ile Asp Lys Asp Lys Pro Lys Glu Ala Val 
            500                 505                 510         


Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys Asp Leu 
        515                 520                 525             


Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys His 
    530                 535                 540                 


Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly Pro Leu 
545                 550                 555                 560 


Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu Tyr Leu 
                565                 570                 575     


Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile Asn Arg 
            580                 585                 590         


Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val Ser Cys Thr Tyr 
        595                 600                 605             


Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile His 
    610                 615                 620                 


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn Val Met 
625                 630                 635                 640 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile Asp Tyr 
                645                 650                 655     


Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
            660                 665                 670         


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
        675                 680                 685             


Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
    690                 695                 700                 


Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly His 
705                 710                 715                 720 


Arg Met Asp Lys Pro Thr Asn Cys Thr Asn Glu Leu Tyr Met Met Met 
                725                 730                 735     


Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln 
            740                 745                 750         


Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn Glu Glu 
        755                 760                 765             


Tyr Leu Asp Leu Thr Gln Pro Leu Glu Gln Tyr Ser Pro Ser Tyr Pro 
    770                 775                 780                 


Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe Ser Pro 
785                 790                 795                 800 


Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His Ile Asn 
                805                 810                 815     


Gly Ser Val Lys Thr 
            820     


<210> 85
<211> 841
<212> PRT
<213> Rattus norvegicus

<400> 85
Met Gly Leu Pro Ser Thr Trp Arg Tyr Gly Thr Gly Pro Gly Ile Gly 
1               5                   10                  15      


Thr Val Thr Met Val Ser Trp Gly Arg Phe Ile Cys Leu Val Leu Val 
            20                  25                  30          


Thr Met Ala Thr Leu Ser Leu Ala Arg Pro Ser Phe Ser Leu Val Glu 
        35                  40                  45              


Asp Thr Thr Leu Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser 
    50                  55                  60                  


Gln Pro Glu Ala Cys Val Val Ala Pro Gly Glu Ser Leu Glu Leu Arg 
65                  70                  75                  80  


Cys Met Leu Lys Asp Ala Ala Val Ile Ser Trp Thr Lys Asp Gly Val 
                85                  90                  95      


His Leu Gly Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln 
            100                 105                 110         


Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Ala Ala 
        115                 120                 125             


Ala Arg Thr Val Asp Ser Glu Thr Leu Tyr Phe Met Val Asn Val Thr 
    130                 135                 140                 


Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Thr Asp Ser Ser Glu 
145                 150                 155                 160 


Asp Phe Val Ser Glu Asn Arg Ser Asn Gln Arg Ala Pro Tyr Trp Thr 
                165                 170                 175     


Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn 
            180                 185                 190         


Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Pro Thr Met 
        195                 200                 205             


Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly 
    210                 215                 220                 


Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val 
225                 230                 235                 240 


Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Leu Val Glu Asn Glu Tyr 
                245                 250                 255     


Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro 
            260                 265                 270         


His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val 
        275                 280                 285             


Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln 
    290                 295                 300                 


Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr 
305                 310                 315                 320 


Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile 
                325                 330                 335     


Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Met 
            340                 345                 350         


Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala 
        355                 360                 365             


Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Val 
    370                 375                 380                 


Arg Glu Lys Glu Ile Thr Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile 
385                 390                 395                 400 


Tyr Cys Ile Gly Val Phe Leu Ile Ala Cys Met Val Val Thr Val Ile 
                405                 410                 415     


Phe Cys Arg Met Lys Thr Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln 
            420                 425                 430         


Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val 
        435                 440                 445             


Thr Val Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu 
    450                 455                 460                 


Val Arg Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu 
465                 470                 475                 480 


Ala Gly Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe 
                485                 490                 495     


Pro Arg Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe 
            500                 505                 510         


Gly Gln Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Asp Arg Pro 
        515                 520                 525             


Lys Glu Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr 
    530                 535                 540                 


Glu Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met 
545                 550                 555                 560 


Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln 
                565                 570                 575     


Asp Gly Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu 
            580                 585                 590         


Arg Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr 
        595                 600                 605             


Asp Ile Asn Arg Val Pro Glu Glu Gln Met Thr Phe Lys Asp Leu Val 
    610                 615                 620                 


Ser Cys Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln 
625                 630                 635                 640 


Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu 
                645                 650                 655     


Asn Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn 
            660                 665                 670         


Asn Ile Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys 
        675                 680                 685             


Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser 
    690                 695                 700                 


Asp Val Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly 
705                 710                 715                 720 


Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu 
                725                 730                 735     


Lys Glu Gly His Arg Met Asp Lys Pro Thr Asn Cys Thr Asn Glu Leu 
            740                 745                 750         


Tyr Met Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro 
        755                 760                 765             


Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr 
    770                 775                 780                 


Thr Asn Glu Glu Tyr Leu Asp Leu Thr Gln Pro Leu Glu Gln Tyr Ser 
785                 790                 795                 800 


Pro Ser Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser 
                805                 810                 815     


Val Phe Ser Pro Asp Pro Met Pro Tyr Asp Pro Cys Leu Pro Gln Tyr 
            820                 825                 830         


Pro His Ile Asn Gly Ser Val Lys Thr 
        835                 840     


<210> 86
<211> 839
<212> PRT
<213> Bos taurus

<400> 86
Met Gly Leu Thr Ser Thr Trp Arg Tyr Gly Arg Gly Gln Gly Ile Gly 
1               5                   10                  15      


Thr Val Thr Met Val Ser Trp Gly Arg Phe Leu Cys Leu Val Val Val 
            20                  25                  30          


Thr Met Ala Thr Leu Ser Leu Ala Arg Pro Ser Phe Asn Leu Val Asp 
        35                  40                  45              


Asp Thr Thr Val Glu Pro Glu Glu Pro Pro Thr Lys Tyr Gln Ile Ser 
    50                  55                  60                  


Gln Pro Glu Val Tyr Val Ala Ala Pro Arg Glu Ser Leu Glu Leu Arg 
65                  70                  75                  80  


Cys Leu Leu Arg Asp Ala Ala Met Ile Ser Trp Thr Lys Asp Gly Val 
                85                  90                  95      


His Leu Gly Pro Asn Asn Arg Thr Val Leu Ile Gly Glu Tyr Leu Gln 
            100                 105                 110         


Ile Lys Gly Ala Thr Pro Arg Asp Ser Gly Leu Tyr Ala Cys Thr Ala 
        115                 120                 125             


Ala Arg Asn Val Asp Ser Glu Thr Val Tyr Phe Met Val Asn Val Thr 
    130                 135                 140                 


Asp Ala Ile Ser Ser Gly Asp Asp Glu Asp Asp Ala Asp Gly Ser Glu 
145                 150                 155                 160 


Asp Phe Val Ser Glu Asn Ser Asn Ser Lys Arg Ala Pro Tyr Trp Thr 
                165                 170                 175     


Asn Thr Glu Lys Met Glu Lys Arg Leu His Ala Val Pro Ala Ala Asn 
            180                 185                 190         


Thr Val Lys Phe Arg Cys Pro Ala Gly Gly Asn Pro Thr Pro Thr Met 
        195                 200                 205             


Arg Trp Leu Lys Asn Gly Lys Glu Phe Lys Gln Glu His Arg Ile Gly 
    210                 215                 220                 


Gly Tyr Lys Val Arg Asn Gln His Trp Ser Leu Ile Met Glu Ser Val 
225                 230                 235                 240 


Val Pro Ser Asp Lys Gly Asn Tyr Thr Cys Val Val Glu Asn Asp Tyr 
                245                 250                 255     


Gly Ser Ile Asn His Thr Tyr His Leu Asp Val Val Glu Arg Ser Pro 
            260                 265                 270         


His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Ala Ser Thr Val 
        275                 280                 285             


Val Gly Gly Asp Val Glu Phe Val Cys Lys Val Tyr Ser Asp Ala Gln 
    290                 295                 300                 


Pro His Ile Gln Trp Ile Lys His Val Glu Lys Asn Gly Ser Lys Tyr 
305                 310                 315                 320 


Gly Pro Asp Gly Leu Pro Tyr Leu Lys Val Leu Lys His Ser Gly Ile 
                325                 330                 335     


Asn Ser Ser Asn Ala Glu Val Leu Ala Leu Phe Asn Val Thr Glu Ala 
            340                 345                 350         


Asp Ala Gly Glu Tyr Ile Cys Lys Val Ser Asn Tyr Ile Gly Gln Ala 
        355                 360                 365             


Asn Gln Ser Ala Trp Leu Thr Val Leu Pro Lys Gln Gln Ala Pro Val 
    370                 375                 380                 


Arg Glu Lys Glu Ile Pro Ala Ser Pro Asp Tyr Leu Glu Ile Ala Ile 
385                 390                 395                 400 


Tyr Cys Ile Gly Val Phe Phe Ile Ala Cys Met Val Val Thr Val Ile 
                405                 410                 415     


Leu Cys Arg Met Arg Asn Thr Thr Lys Lys Pro Asp Phe Ser Ser Gln 
            420                 425                 430         


Pro Ala Val His Lys Leu Thr Lys Arg Ile Pro Leu Arg Arg Gln Val 
        435                 440                 445             


Ser Ala Glu Ser Ser Ser Ser Met Asn Ser Asn Thr Pro Leu Val Arg 
    450                 455                 460                 


Ile Thr Thr Arg Leu Ser Ser Thr Ala Asp Thr Pro Met Leu Ala Gly 
465                 470                 475                 480 


Val Ser Glu Tyr Glu Leu Pro Glu Asp Pro Lys Trp Glu Phe Pro Arg 
                485                 490                 495     


Asp Lys Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
            500                 505                 510         


Val Val Met Ala Glu Ala Val Gly Ile Asp Lys Glu Lys Pro Lys Glu 
        515                 520                 525             


Ala Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Glu Lys 
    530                 535                 540                 


Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly 
545                 550                 555                 560 


Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Asp Gly 
                565                 570                 575     


Pro Leu Tyr Val Ile Val Glu Tyr Ala Ser Lys Gly Asn Leu Arg Glu 
            580                 585                 590         


Tyr Leu Arg Ala Arg Arg Pro Pro Gly Met Glu Tyr Ser Tyr Asp Ile 
        595                 600                 605             


Asn Arg Val Pro Glu Glu Gln Met Ala Phe Lys Asp Leu Val Ser Cys 
    610                 615                 620                 


Thr Tyr Gln Leu Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys 
625                 630                 635                 640 


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asn Asn 
                645                 650                 655     


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Ile Asn Asn Ile 
            660                 665                 670         


Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met 
        675                 680                 685             


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
    690                 695                 700                 


Trp Ser Phe Gly Val Leu Met Trp Glu Ile Phe Thr Leu Gly Gly Ser 
705                 710                 715                 720 


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu 
                725                 730                 735     


Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr Asn Glu Leu Tyr Met 
            740                 745                 750         


Met Met Arg Asp Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe 
        755                 760                 765             


Lys Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Leu Thr Thr Asn 
    770                 775                 780                 


Glu Glu Tyr Leu Asp Leu Ser Gln Leu Leu Glu Gln Tyr Ser Pro Ser 
785                 790                 795                 800 


Tyr Pro Asp Thr Arg Ser Ser Cys Ser Ser Gly Asp Asp Ser Val Phe 
                805                 810                 815     


Ser Pro Asp Pro Met Pro Tyr Glu Pro Cys Leu Pro Gln Tyr Pro His 
            820                 825                 830         


Arg Asn Gly Ser Val Lys Thr 
        835                 


<210> 87
<211> 806
<212> PRT
<213> Homo sapiens

<400> 87
Met Gly Ala Pro Ala Cys Ala Leu Ala Leu Cys Val Ala Val Ala Ile 
1               5                   10                  15      


Val Ala Gly Ala Ser Ser Glu Ser Leu Gly Thr Glu Gln Arg Val Val 
            20                  25                  30          


Gly Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Gly Gln Gln Glu Gln 
        35                  40                  45              


Leu Val Phe Gly Ser Gly Asp Ala Val Glu Leu Ser Cys Pro Pro Pro 
    50                  55                  60                  


Gly Gly Gly Pro Met Gly Pro Thr Val Trp Val Lys Asp Gly Thr Gly 
65                  70                  75                  80  


Leu Val Pro Ser Glu Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val 
                85                  90                  95      


Leu Asn Ala Ser His Glu Asp Ser Gly Ala Tyr Ser Cys Arg Gln Arg 
            100                 105                 110         


Leu Thr Gln Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala 
        115                 120                 125             


Pro Ser Ser Gly Asp Asp Glu Asp Gly Glu Asp Glu Ala Glu Asp Thr 
    130                 135                 140                 


Gly Val Asp Thr Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp 
145                 150                 155                 160 


Lys Lys Leu Leu Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys 
                165                 170                 175     


Pro Ala Ala Gly Asn Pro Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly 
            180                 185                 190         


Arg Glu Phe Arg Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg His 
        195                 200                 205             


Gln Gln Trp Ser Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly 
    210                 215                 220                 


Asn Tyr Thr Cys Val Val Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr 
225                 230                 235                 240 


Tyr Thr Leu Asp Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln 
                245                 250                 255     


Ala Gly Leu Pro Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu 
            260                 265                 270         


Phe His Cys Lys Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu 
        275                 280                 285             


Lys His Val Glu Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro 
    290                 295                 300                 


Tyr Val Thr Val Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu 
305                 310                 315                 320 


Leu Glu Val Leu Ser Leu His Asn Val Thr Phe Glu Asp Ala Gly Glu 
                325                 330                 335     


Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala 
            340                 345                 350         


Trp Leu Val Val Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Asp Glu 
        355                 360                 365             


Ala Gly Ser Val Tyr Ala Gly Ile Leu Ser Tyr Gly Val Gly Phe Phe 
    370                 375                 380                 


Leu Phe Ile Leu Val Val Ala Ala Val Thr Leu Cys Arg Leu Arg Ser 
385                 390                 395                 400 


Pro Pro Lys Lys Gly Leu Gly Ser Pro Thr Val His Lys Ile Ser Arg 
                405                 410                 415     


Phe Pro Leu Lys Arg Gln Val Ser Leu Glu Ser Asn Ala Ser Met Ser 
            420                 425                 430         


Ser Asn Thr Pro Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly 
        435                 440                 445             


Pro Thr Leu Ala Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys 
    450                 455                 460                 


Trp Glu Leu Ser Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu 
465                 470                 475                 480 


Gly Cys Phe Gly Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys 
                485                 490                 495     


Asp Arg Ala Ala Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp 
            500                 505                 510         


Asp Ala Thr Asp Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met 
        515                 520                 525             


Met Lys Met Ile Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala 
    530                 535                 540                 


Cys Thr Gln Gly Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys 
545                 550                 555                 560 


Gly Asn Leu Arg Glu Phe Leu Arg Ala Arg Arg Pro Pro Gly Leu Asp 
                565                 570                 575     


Tyr Ser Phe Asp Thr Cys Lys Pro Pro Glu Glu Gln Leu Thr Phe Lys 
            580                 585                 590         


Asp Leu Val Ser Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu 
        595                 600                 605             


Ala Ser Gln Lys Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu 
    610                 615                 620                 


Val Thr Glu Asp Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg 
625                 630                 635                 640 


Asp Val His Asn Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu 
                645                 650                 655     


Pro Val Lys Trp Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr 
            660                 665                 670         


His Gln Ser Asp Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe 
        675                 680                 685             


Thr Leu Gly Gly Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe 
    690                 695                 700                 


Lys Leu Leu Lys Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr 
705                 710                 715                 720 


His Asp Leu Tyr Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser 
                725                 730                 735     


Gln Arg Pro Thr Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu 
            740                 745                 750         


Thr Val Thr Ser Thr Asp Glu Tyr Leu Asp Leu Ser Ala Pro Phe Glu 
        755                 760                 765             


Gln Tyr Ser Pro Gly Gly Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly 
    770                 775                 780                 


Asp Asp Ser Val Phe Ala His Asp Leu Leu Pro Pro Ala Pro Pro Ser 
785                 790                 795                 800 


Ser Gly Gly Ser Arg Thr 
                805     


<210> 88
<211> 800
<212> PRT
<213> Mus musculus

<400> 88
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala 
1               5                   10                  15      


Gly Ala Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Val Arg Arg 
            20                  25                  30          


Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala 
        35                  40                  45              


Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly 
    50                  55                  60                  


Ala Pro Thr Gly Pro Thr Val Trp Ala Lys Asp Gly Thr Gly Leu Val 
65                  70                  75                  80  


Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn 
                85                  90                  95      


Ala Ser His Glu Asp Ala Gly Val Tyr Ser Cys Gln His Arg Leu Thr 
            100                 105                 110         


Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser 
        115                 120                 125             


Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala 
    130                 135                 140                 


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
145                 150                 155                 160 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
                165                 170                 175     


Thr Pro Ser Ile Ser Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu 
            180                 185                 190         


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
        195                 200                 205             


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
    210                 215                 220                 


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
225                 230                 235                 240 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                245                 250                 255     


Gln Thr Ala Ile Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
            260                 265                 270         


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
        275                 280                 285             


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
    290                 295                 300                 


Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu Ser Leu 
305                 310                 315                 320 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
            340                 345                 350         


Ala Glu Glu Glu Leu Met Glu Thr Asp Glu Ala Gly Ser Val Tyr Ala 
        355                 360                 365             


Gly Val Leu Ser Tyr Gly Val Val Phe Phe Leu Phe Ile Leu Val Val 
    370                 375                 380                 


Ala Ala Val Ile Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu 
385                 390                 395                 400 


Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln 
                405                 410                 415     


Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val 
            420                 425                 430         


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val 
        435                 440                 445             


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr 
    450                 455                 460                 


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
465                 470                 475                 480 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro 
                485                 490                 495     


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
            500                 505                 510         


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
        515                 520                 525             


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
    530                 535                 540                 


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
545                 550                 555                 560 


Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys 
                565                 570                 575     


Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala 
            580                 585                 590         


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
        595                 600                 605             


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
    610                 615                 620                 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
625                 630                 635                 640 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
                645                 650                 655     


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
            660                 665                 670         


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
        675                 680                 685             


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
    690                 695                 700                 


His Arg Met Asp Lys Pro Ala Ser Cys Thr His Asp Leu Tyr Met Ile 
705                 710                 715                 720 


Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
                725                 730                 735     


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr Asp 
            740                 745                 750         


Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
        755                 760                 765             


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Thr 
    770                 775                 780                 


His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg Thr 
785                 790                 795                 800 


<210> 89
<211> 800
<212> PRT
<213> Rattus norvegicus

<400> 89
Met Val Val Pro Ala Cys Val Leu Val Phe Cys Val Ala Val Val Ala 
1               5                   10                  15      


Gly Val Thr Ser Glu Pro Pro Gly Pro Glu Gln Arg Val Gly Arg Arg 
            20                  25                  30          


Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Gln Gln Glu Gln Val Ala 
        35                  40                  45              


Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys His Pro Pro Gly Gly 
    50                  55                  60                  


Ala Pro Thr Gly Pro Thr Leu Trp Ala Lys Asp Gly Val Gly Leu Val 
65                  70                  75                  80  


Ala Ser His Arg Ile Leu Val Gly Pro Gln Arg Leu Gln Val Leu Asn 
                85                  90                  95      


Ala Thr His Glu Asp Ala Gly Val Tyr Ser Cys Gln Gln Arg Leu Thr 
            100                 105                 110         


Arg Arg Val Leu Cys His Phe Ser Val Arg Val Thr Asp Ala Pro Ser 
        115                 120                 125             


Ser Gly Asp Asp Glu Asp Gly Glu Asp Val Ala Glu Asp Thr Gly Ala 
    130                 135                 140                 


Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu Ala Val 
145                 150                 155                 160 


Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly Asn Pro 
                165                 170                 175     


Thr Pro Ser Ile Pro Trp Leu Lys Asn Gly Lys Glu Phe Arg Gly Glu 
            180                 185                 190         


His Arg Ile Gly Gly Ile Lys Leu Arg His Gln Gln Trp Ser Leu Val 
        195                 200                 205             


Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys Val Val 
    210                 215                 220                 


Glu Asn Lys Phe Gly Ser Ile Arg Gln Thr Tyr Thr Leu Asp Val Leu 
225                 230                 235                 240 


Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn 
                245                 250                 255     


Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys Val Tyr 
            260                 265                 270         


Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu Val Asn 
        275                 280                 285             


Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val Leu Lys 
    290                 295                 300                 


Thr Ala Gly Ala Asn Thr Thr Asp Arg Glu Leu Glu Val Leu Ser Leu 
305                 310                 315                 320 


His Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val Leu Pro 
            340                 345                 350         


Ala Glu Glu Glu Leu Met Glu Val Asp Glu Ala Gly Ser Val Tyr Ala 
        355                 360                 365             


Gly Val Leu Ser Tyr Gly Val Gly Phe Phe Leu Phe Ile Leu Val Val 
    370                 375                 380                 


Ala Ala Val Thr Leu Cys Arg Leu Arg Ser Pro Pro Lys Lys Gly Leu 
385                 390                 395                 400 


Gly Ser Pro Thr Val His Lys Val Ser Arg Phe Pro Leu Lys Arg Gln 
                405                 410                 415     


Val Ser Leu Glu Ser Asn Ser Ser Met Asn Ser Asn Thr Pro Leu Val 
            420                 425                 430         


Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Val Leu Ala Asn Val 
        435                 440                 445             


Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser Arg Thr 
    450                 455                 460                 


Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
465                 470                 475                 480 


Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Thr Ala Lys Pro 
                485                 490                 495     


Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp Lys Asp 
            500                 505                 510         


Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile Gly Lys 
        515                 520                 525             


His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly Gly Pro 
    530                 535                 540                 


Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe 
545                 550                 555                 560 


Leu Arg Ala Arg Arg Pro Pro Gly Met Asp Tyr Ser Phe Asp Ala Cys 
                565                 570                 575     


Arg Leu Pro Glu Glu Gln Leu Thr Cys Lys Asp Leu Val Ser Cys Ala 
            580                 585                 590         


Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys Cys Ile 
        595                 600                 605             


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
    610                 615                 620                 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn Leu Asp 
625                 630                 635                 640 


Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
                645                 650                 655     


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
            660                 665                 670         


Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
        675                 680                 685             


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys Glu Gly 
    690                 695                 700                 


His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr Met Ile 
705                 710                 715                 720 


Met Arg Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys 
                725                 730                 735     


Gln Leu Val Glu Asp Leu Asp Arg Ile Leu Thr Val Thr Ser Thr Asp 
            740                 745                 750         


Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro Gly Gly 
        755                 760                 765             


Gln Asp Thr Pro Ser Ser Ser Ser Ser Gly Asp Asp Ser Val Phe Thr 
    770                 775                 780                 


His Asp Leu Leu Pro Pro Gly Pro Pro Ser Asn Gly Gly Pro Arg Thr 
785                 790                 795                 800 


<210> 90
<211> 802
<212> PRT
<213> Bos taurus

<400> 90
Met Gly Ala Pro Ala Arg Ala Leu Ala Phe Cys Val Ala Val Ala Val 
1               5                   10                  15      


Met Thr Gly Ala Ala Leu Gly Ser Pro Gly Val Glu Pro Arg Val Ala 
            20                  25                  30          


Arg Arg Ala Ala Glu Val Pro Gly Pro Glu Pro Ser Pro Gln Glu Arg 
        35                  40                  45              


Ala Phe Gly Ser Gly Asp Thr Val Glu Leu Ser Cys Arg Leu Pro Ala 
    50                  55                  60                  


Gly Val Pro Thr Glu Pro Thr Val Trp Val Lys Asp Gly Val Gly Leu 
65                  70                  75                  80  


Ala Pro Ser Asp Arg Val Leu Val Gly Pro Gln Arg Leu Gln Val Leu 
                85                  90                  95      


Asn Ala Ser His Glu Asp Ala Gly Ala Tyr Ser Cys Arg Gln Arg Leu 
            100                 105                 110         


Ser Gln Arg Leu Leu Cys Leu Phe Ser Val Arg Val Thr Asp Ala Pro 
        115                 120                 125             


Ser Ser Gly Asp Asp Glu Gly Gly Asp Asp Glu Ala Glu Asp Thr Ala 
    130                 135                 140                 


Gly Ala Pro Tyr Trp Thr Arg Pro Glu Arg Met Asp Lys Lys Leu Leu 
145                 150                 155                 160 


Ala Val Pro Ala Ala Asn Thr Val Arg Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Ser Ile Thr Trp Leu Lys Asn Gly Lys Glu Phe Arg 
            180                 185                 190         


Gly Glu His Arg Ile Gly Gly Ile Lys Leu Arg Gln Gln Gln Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Asn Tyr Thr Cys 
    210                 215                 220                 


Val Val Glu Asn Lys Phe Gly Arg Ile Gln Gln Thr Tyr Thr Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Gln Thr Ala Val Leu Gly Ser Asp Val Glu Phe His Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Glu 
        275                 280                 285             


Val Asn Gly Ser Lys Val Gly Pro Asp Gly Thr Pro Tyr Val Thr Val 
    290                 295                 300                 


Leu Lys Thr Ala Gly Ala Asn Thr Thr Asp Lys Glu Leu Glu Val Leu 
305                 310                 315                 320 


Ser Leu Arg Asn Val Thr Phe Glu Asp Ala Gly Glu Tyr Thr Cys Leu 
                325                 330                 335     


Ala Gly Asn Ser Ile Gly Phe Ser His His Ser Ala Trp Leu Val Val 
            340                 345                 350         


Leu Pro Ala Glu Glu Glu Leu Val Glu Ala Gly Glu Ala Gly Gly Val 
        355                 360                 365             


Phe Ala Gly Val Leu Ser Tyr Gly Leu Gly Phe Leu Leu Phe Ile Leu 
    370                 375                 380                 


Ala Val Ala Ala Val Thr Leu Tyr Arg Leu Arg Ser Pro Pro Lys Lys 
385                 390                 395                 400 


Gly Leu Gly Ser Pro Ala Val His Lys Val Ser Arg Phe Pro Leu Lys 
                405                 410                 415     


Arg Gln Val Ser Leu Glu Ser Ser Ser Ser Met Ser Ser Asn Thr Pro 
            420                 425                 430         


Leu Val Arg Ile Ala Arg Leu Ser Ser Gly Glu Gly Pro Thr Leu Ala 
        435                 440                 445             


Asn Val Ser Glu Leu Glu Leu Pro Ala Asp Pro Lys Trp Glu Leu Ser 
    450                 455                 460                 


Arg Ala Arg Leu Thr Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly 
465                 470                 475                 480 


Gln Val Val Met Ala Glu Ala Ile Gly Ile Asp Lys Asp Arg Ala Ala 
                485                 490                 495     


Lys Pro Val Thr Val Ala Val Lys Met Leu Lys Asp Asp Ala Thr Asp 
            500                 505                 510         


Lys Asp Leu Ser Asp Leu Val Ser Glu Met Glu Met Met Lys Met Ile 
        515                 520                 525             


Gly Lys His Lys Asn Ile Ile Asn Leu Leu Gly Ala Cys Thr Gln Gly 
    530                 535                 540                 


Gly Pro Leu Tyr Val Leu Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg 
545                 550                 555                 560 


Glu Tyr Leu Arg Ala Arg Arg Pro Pro Gly Thr Asp Tyr Ser Phe Asp 
                565                 570                 575     


Thr Cys Arg Leu Pro Glu Glu Gln Leu Thr Phe Lys Asp Leu Val Ser 
            580                 585                 590         


Cys Ala Tyr Gln Val Ala Arg Gly Met Glu Tyr Leu Ala Ser Gln Lys 
        595                 600                 605             


Cys Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp 
    610                 615                 620                 


Asn Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Asp Val His Asn 
625                 630                 635                 640 


Leu Asp Tyr Tyr Lys Lys Thr Thr Asn Gly Arg Leu Pro Val Lys Trp 
                645                 650                 655     


Met Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp 
            660                 665                 670         


Val Trp Ser Phe Gly Val Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly 
        675                 680                 685             


Ser Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Lys Leu Leu Lys 
    690                 695                 700                 


Glu Gly His Arg Met Asp Lys Pro Ala Asn Cys Thr His Asp Leu Tyr 
705                 710                 715                 720 


Met Ile Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr 
                725                 730                 735     


Phe Lys Gln Leu Val Glu Asp Leu Asp Arg Val Leu Thr Val Thr Ser 
            740                 745                 750         


Thr Asp Glu Tyr Leu Asp Leu Ser Val Pro Phe Glu Gln Tyr Ser Pro 
        755                 760                 765             


Gly Gly Gln Asp Thr Pro Ser Ser Gly Ser Ser Gly Asp Asp Ser Val 
    770                 775                 780                 


Phe Ala His Asp Leu Leu Pro Pro Ala Pro Ser Gly Ser Gly Gly Ser 
785                 790                 795                 800 


Arg Thr 
        


<210> 91
<211> 802
<212> PRT
<213> Homo sapiens

<400> 91
Met Arg Leu Leu Leu Ala Leu Leu Gly Val Leu Leu Ser Val Pro Gly 
1               5                   10                  15      


Pro Pro Val Leu Ser Leu Glu Ala Ser Glu Glu Val Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Leu Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Gly Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Ala Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Arg Tyr Leu Cys Leu Ala Arg Gly Ser Met Ile Val Leu Gln Asn 
            100                 105                 110         


Leu Thr Leu Ile Thr Gly Asp Ser Leu Thr Ser Ser Asn Asp Asp Glu 
        115                 120                 125             


Asp Pro Lys Ser His Arg Asp Pro Ser Asn Arg His Ser Tyr Pro Gln 
    130                 135                 140                 


Gln Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His 
145                 150                 155                 160 


Ala Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly 
                165                 170                 175     


Asn Pro Thr Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Ala Phe His 
            180                 185                 190         


Gly Glu Asn Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser 
        195                 200                 205             


Leu Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys 
    210                 215                 220                 


Leu Val Glu Asn Ala Val Gly Ser Ile Arg Tyr Asn Tyr Leu Leu Asp 
225                 230                 235                 240 


Val Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro 
                245                 250                 255     


Ala Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys 
            260                 265                 270         


Val Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val 
        275                 280                 285             


Ile Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val 
    290                 295                 300                 


Leu Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu 
305                 310                 315                 320 


Arg Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly 
                325                 330                 335     


Asn Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro 
            340                 345                 350         


Glu Glu Asp Pro Thr Trp Thr Ala Ala Ala Pro Glu Ala Arg Tyr Thr 
        355                 360                 365             


Asp Ile Ile Leu Tyr Ala Ser Gly Ser Leu Ala Leu Ala Val Leu Leu 
    370                 375                 380                 


Leu Leu Ala Gly Leu Tyr Arg Gly Gln Ala Leu His Gly Arg His Pro 
385                 390                 395                 400 


Arg Pro Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg 
                405                 410                 415     


Gln Phe Ser Leu Glu Ser Gly Ser Ser Gly Lys Ser Ser Ser Ser Leu 
            420                 425                 430         


Val Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Ala Leu Leu Ala Gly 
        435                 440                 445             


Leu Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg 
    450                 455                 460                 


Asp Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln 
465                 470                 475                 480 


Val Val Arg Ala Glu Ala Phe Gly Met Asp Pro Ala Arg Pro Asp Gln 
                485                 490                 495     


Ala Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys 
            500                 505                 510         


Asp Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly 
        515                 520                 525             


Arg His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly 
    530                 535                 540                 


Pro Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu 
545                 550                 555                 560 


Phe Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly 
                565                 570                 575     


Pro Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Val Leu Val Ser Cys 
            580                 585                 590         


Ala Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys 
        595                 600                 605             


Ile His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn 
    610                 615                 620                 


Val Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile 
625                 630                 635                 640 


Asp Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met 
                645                 650                 655     


Ala Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val 
            660                 665                 670         


Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser 
        675                 680                 685             


Pro Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu 
    690                 695                 700                 


Gly His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly 
705                 710                 715                 720 


Leu Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe 
                725                 730                 735     


Lys Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu 
            740                 745                 750         


Glu Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ser Gly 
        755                 760                 765             


Gly Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His 
    770                 775                 780                 


Asp Pro Leu Pro Leu Gly Ser Ser Ser Phe Pro Phe Gly Ser Gly Val 
785                 790                 795                 800 


Gln Thr 
        


<210> 92
<211> 799
<212> PRT
<213> Mus musculus

<400> 92
Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Gly Thr Pro Ala 
1               5                   10                  15      


Leu Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Leu Ala 
            20                  25                  30          


Pro Ile Leu Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Leu Met Asp Asp Ser Leu Thr Ser Ile Ser Asn Asp Glu Asp Pro Lys 
        115                 120                 125             


Thr Leu Ser Ser Ser Ser Ser Gly His Val Tyr Pro Gln Gln Ala Pro 
    130                 135                 140                 


Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro 
145                 150                 155                 160 


Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met 
                165                 170                 175     


Pro Thr Ile His Trp Leu Lys Asp Gly Gln Ala Phe His Gly Glu Asn 
            180                 185                 190         


Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met 
        195                 200                 205             


Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu 
    210                 215                 220                 


Asn Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu 
225                 230                 235                 240 


Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr 
                245                 250                 255     


Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val Tyr Ser 
            260                 265                 270         


Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Val Val Ile Asn Gly 
        275                 280                 285             


Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr 
    290                 295                 300                 


Thr Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val 
305                 310                 315                 320 


Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile 
                325                 330                 335     


Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu Glu Asp 
            340                 345                 350         


Leu Thr Trp Thr Thr Ala Thr Pro Glu Ala Arg Tyr Thr Asp Ile Ile 
        355                 360                 365             


Leu Tyr Val Ser Gly Ser Leu Val Leu Leu Val Leu Leu Leu Leu Ala 
    370                 375                 380                 


Gly Val Tyr His Arg Gln Val Ile Arg Gly His Tyr Ser Arg Gln Pro 
385                 390                 395                 400 


Val Thr Ile Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe Ser 
                405                 410                 415     


Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg Gly 
            420                 425                 430         


Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val Asn 
        435                 440                 445             


Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg Leu 
    450                 455                 460                 


Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val Arg 
465                 470                 475                 480 


Ala Glu Ala Phe Gly Met Asp Pro Ser Arg Pro Asp Gln Thr Ser Thr 
                485                 490                 495     


Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu Ala 
            500                 505                 510         


Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg His Lys 
        515                 520                 525             


Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu Tyr 
    530                 535                 540                 


Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu Arg 
545                 550                 555                 560 


Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg Ser 
                565                 570                 575     


Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr Gln 
            580                 585                 590         


Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His Arg 
        595                 600                 605             


Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met Lys 
    610                 615                 620                 


Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr Tyr 
625                 630                 635                 640 


Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro Glu 
                645                 650                 655     


Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser Phe 
            660                 665                 670         


Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr Pro 
        675                 680                 685             


Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His Arg 
    690                 695                 700                 


Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met Arg 
705                 710                 715                 720 


Glu Cys Trp His Ala Val Pro Ser Gln Arg Pro Thr Phe Lys Gln Leu 
                725                 730                 735     


Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr Leu 
            740                 745                 750         


Asp Leu Arg Leu Thr Phe Gly Pro Phe Ser Pro Ser Asn Gly Asp Ala 
        755                 760                 765             


Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro Leu 
    770                 775                 780                 


Pro Leu Glu Pro Ser Pro Phe Pro Phe Ser Asp Ser Gln Thr Thr 
785                 790                 795                 


<210> 93
<211> 800
<212> PRT
<213> Rattus norvegicus

<400> 93
Met Trp Leu Leu Leu Ala Leu Leu Ser Ile Phe Gln Glu Thr Pro Ala 
1               5                   10                  15      


Phe Ser Leu Glu Ala Ser Glu Glu Met Glu Gln Glu Pro Cys Pro Ala 
            20                  25                  30          


Pro Ile Ser Glu Gln Gln Glu Gln Val Leu Thr Val Ala Leu Gly Gln 
        35                  40                  45              


Pro Val Arg Leu Cys Cys Gly Arg Thr Glu Arg Gly Arg His Trp Tyr 
    50                  55                  60                  


Lys Glu Gly Ser Arg Leu Ala Ser Ala Gly Arg Val Arg Gly Trp Arg 
65                  70                  75                  80  


Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala Gly Arg Tyr 
                85                  90                  95      


Leu Cys Leu Ala Arg Gly Ser Met Thr Val Val His Asn Leu Thr Leu 
            100                 105                 110         


Ile Met Asp Asp Ser Leu Pro Ser Ile Asn Asn Glu Asp Pro Lys Thr 
        115                 120                 125             


Leu Ser Ser Ser Ser Ser Gly His Ser Tyr Leu Gln Gln Ala Pro Tyr 
    130                 135                 140                 


Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala Val Pro Ala 
145                 150                 155                 160 


Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn Pro Met Pro 
                165                 170                 175     


Thr Ile His Trp Leu Lys Asn Gly Gln Ala Phe His Gly Glu Asn Arg 
            180                 185                 190         


Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu Val Met Glu 
        195                 200                 205             


Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu Val Glu Asn 
    210                 215                 220                 


Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val Leu Glu Arg 
225                 230                 235                 240 


Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala Asn Thr Thr 
                245                 250                 255     


Ala Val Val Gly Ser Asn Val Glu Leu Leu Cys Lys Val Tyr Ser Asp 
            260                 265                 270         


Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile Asn Gly Ser 
        275                 280                 285             


Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu Lys Thr Thr 
    290                 295                 300                 


Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg Asn Val Ser 
305                 310                 315                 320 


Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn Ser Ile Gly 
                325                 330                 335     


Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Ala Glu Glu Glu 
            340                 345                 350         


Asp Leu Ala Trp Thr Thr Ala Thr Ser Glu Ala Arg Tyr Thr Asp Ile 
        355                 360                 365             


Ile Leu Tyr Val Ser Gly Ser Leu Ala Leu Val Leu Leu Leu Leu Leu 
    370                 375                 380                 


Ala Gly Val Tyr His Arg Gln Ala Ile His Gly His His Ser Arg Gln 
385                 390                 395                 400 


Pro Val Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln Phe 
                405                 410                 415     


Ser Leu Glu Ser Arg Ser Ser Gly Lys Ser Ser Leu Ser Leu Val Arg 
            420                 425                 430         


Gly Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Thr Gly Leu Val 
        435                 440                 445             


Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp Arg 
    450                 455                 460                 


Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val Val 
465                 470                 475                 480 


Arg Ala Glu Ala Leu Gly Met Asp Ser Ser Arg Pro Asp Gln Thr Ser 
                485                 490                 495     


Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp Leu 
            500                 505                 510         


Ala Asp Leu Ile Ser Glu Met Glu Met Met Lys Leu Ile Gly Arg His 
        515                 520                 525             


Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro Leu 
    530                 535                 540                 


Tyr Val Ile Val Glu Tyr Ala Ala Lys Gly Asn Leu Arg Glu Phe Leu 
545                 550                 555                 560 


Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro Arg 
                565                 570                 575     


Ser Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala Tyr 
            580                 585                 590         


Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile His 
        595                 600                 605             


Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asp Val Met 
    610                 615                 620                 


Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Val His His Ile Asp Tyr 
625                 630                 635                 640 


Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala Pro 
                645                 650                 655     


Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp Ser 
            660                 665                 670         


Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro Tyr 
        675                 680                 685             


Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly His 
    690                 695                 700                 


Arg Met Glu Arg Pro Pro Asn Cys Pro Ser Glu Leu Tyr Gly Leu Met 
705                 710                 715                 720 


Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys Gln 
                725                 730                 735     


Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu Tyr 
            740                 745                 750         


Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Asn Asn Gly Asp 
        755                 760                 765             


Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp Pro 
    770                 775                 780                 


Leu Pro Leu Glu Pro Ser Pro Phe Pro Phe Pro Glu Ala Gln Thr Thr 
785                 790                 795                 800 


<210> 94
<211> 800
<212> PRT
<213> Bos taurus

<400> 94
Met Arg Leu Leu Leu Val Leu Leu Gly Val Leu Leu Gly Ala Pro Gly 
1               5                   10                  15      


Ala Pro Ala Leu Ser Phe Glu Ala Ser Glu Glu Thr Glu Leu Glu Pro 
            20                  25                  30          


Cys Leu Ala Pro Ser Pro Glu Gln Gln Glu Gln Glu Leu Thr Val Ala 
        35                  40                  45              


Leu Gly Gln Pro Val Arg Leu Cys Cys Gly Arg Ala Glu Arg Ser Gly 
    50                  55                  60                  


His Trp Tyr Lys Glu Gly Ser Arg Leu Thr Pro Ala Gly Arg Val Arg 
65                  70                  75                  80  


Gly Trp Arg Gly Arg Leu Glu Ile Ala Ser Phe Leu Pro Glu Asp Ala 
                85                  90                  95      


Gly Gln Tyr Leu Cys Leu Ser Arg Gly Ser Leu Leu Leu His Asn Val 
            100                 105                 110         


Thr Leu Val Val Asp Asp Ser Met Thr Ser Ser Asn Gly Asp Glu Asp 
        115                 120                 125             


Pro Lys Ile His Arg Gly Pro Leu Asn Gly His Val Tyr Pro Gln Gln 
    130                 135                 140                 


Ala Pro Tyr Trp Thr His Pro Gln Arg Met Glu Lys Lys Leu His Ala 
145                 150                 155                 160 


Val Pro Ala Gly Asn Thr Val Lys Phe Arg Cys Pro Ala Ala Gly Asn 
                165                 170                 175     


Pro Met Pro Thr Ile Arg Trp Leu Lys Asp Gly Gln Asp Phe His Gly 
            180                 185                 190         


Glu His Arg Ile Gly Gly Ile Arg Leu Arg His Gln His Trp Ser Leu 
        195                 200                 205             


Val Met Glu Ser Val Val Pro Ser Asp Arg Gly Thr Tyr Thr Cys Leu 
    210                 215                 220                 


Val Glu Asn Ser Leu Gly Ser Ile Arg Tyr Ser Tyr Leu Leu Asp Val 
225                 230                 235                 240 


Leu Glu Arg Ser Pro His Arg Pro Ile Leu Gln Ala Gly Leu Pro Ala 
                245                 250                 255     


Asn Thr Thr Ala Val Val Gly Ser Asp Val Glu Leu Leu Cys Lys Val 
            260                 265                 270         


Tyr Ser Asp Ala Gln Pro His Ile Gln Trp Leu Lys His Ile Val Ile 
        275                 280                 285             


Asn Gly Ser Ser Phe Gly Ala Asp Gly Phe Pro Tyr Val Gln Val Leu 
    290                 295                 300                 


Lys Thr Ala Asp Ile Asn Ser Ser Glu Val Glu Val Leu Tyr Leu Arg 
305                 310                 315                 320 


Asn Val Ser Ala Glu Asp Ala Gly Glu Tyr Thr Cys Leu Ala Gly Asn 
                325                 330                 335     


Ser Ile Gly Leu Ser Tyr Gln Ser Ala Trp Leu Thr Val Leu Pro Glu 
            340                 345                 350         


Glu Asp Leu Thr Trp Thr Ala Thr Ala Pro Glu Gly Arg Tyr Thr Asp 
        355                 360                 365             


Ile Ile Leu Tyr Ser Ser Gly Ser Leu Ala Leu Ile Val Phe Leu Leu 
    370                 375                 380                 


Leu Val Gly Leu Tyr Arg Arg Gln Thr Leu Leu Thr Arg His His Arg 
385                 390                 395                 400 


Gln Pro Ala Thr Val Gln Lys Leu Ser Arg Phe Pro Leu Ala Arg Gln 
                405                 410                 415     


Phe Ser Leu Glu Ser Gly Ser Ser Ala Lys Ser Ser Leu Ser Leu Val 
            420                 425                 430         


Arg Gly Val Arg Leu Ser Ser Ser Gly Pro Pro Leu Leu Ala Gly Leu 
        435                 440                 445             


Val Ser Leu Asp Leu Pro Leu Asp Pro Leu Trp Glu Phe Pro Arg Asp 
    450                 455                 460                 


Arg Leu Val Leu Gly Lys Pro Leu Gly Glu Gly Cys Phe Gly Gln Val 
465                 470                 475                 480 


Val Cys Ala Glu Ala Phe Gly Met Asp Pro Thr Arg Pro Asp Gln Ala 
                485                 490                 495     


Ser Thr Val Ala Val Lys Met Leu Lys Asp Asn Ala Ser Asp Lys Asp 
            500                 505                 510         


Leu Ala Asp Leu Val Ser Glu Met Glu Val Met Lys Leu Ile Gly Arg 
        515                 520                 525             


His Lys Asn Ile Ile Asn Leu Leu Gly Val Cys Thr Gln Glu Gly Pro 
    530                 535                 540                 


Leu Tyr Val Ile Val Glu Cys Ala Ala Lys Gly Asn Leu Arg Glu Phe 
545                 550                 555                 560 


Leu Arg Ala Arg Arg Pro Pro Gly Pro Asp Leu Ser Pro Asp Gly Pro 
                565                 570                 575     


Arg Ser Ser Glu Gly Pro Leu Ser Phe Pro Ala Leu Val Ser Cys Ala 
            580                 585                 590         


Tyr Gln Val Ala Arg Gly Met Gln Tyr Leu Glu Ser Arg Lys Cys Ile 
        595                 600                 605             


His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Thr Glu Asp Asn Val 
    610                 615                 620                 


Met Lys Ile Ala Asp Phe Gly Leu Ala Arg Gly Ile His His Ile Asp 
625                 630                 635                 640 


Tyr Tyr Lys Lys Thr Ser Asn Gly Arg Leu Pro Val Lys Trp Met Ala 
                645                 650                 655     


Pro Glu Ala Leu Phe Asp Arg Val Tyr Thr His Gln Ser Asp Val Trp 
            660                 665                 670         


Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe Thr Leu Gly Gly Ser Pro 
        675                 680                 685             


Tyr Pro Gly Ile Pro Val Glu Glu Leu Phe Ser Leu Leu Arg Glu Gly 
    690                 695                 700                 


His Arg Met Asp Arg Pro Pro His Cys Pro Pro Glu Leu Tyr Gly Leu 
705                 710                 715                 720 


Met Arg Glu Cys Trp His Ala Ala Pro Ser Gln Arg Pro Thr Phe Lys 
                725                 730                 735     


Gln Leu Val Glu Ala Leu Asp Lys Val Leu Leu Ala Val Ser Glu Glu 
            740                 745                 750         


Tyr Leu Asp Leu Arg Leu Thr Phe Gly Pro Tyr Ser Pro Ala Gly Gly 
        755                 760                 765             


Asp Ala Ser Ser Thr Cys Ser Ser Ser Asp Ser Val Phe Ser His Asp 
    770                 775                 780                 


Pro Leu Pro Leu Arg Pro Ser Ser Phe Ser Phe Pro Gly Val Gln Thr 
785                 790                 795                 800 


<210> 95
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 95
caagctgcac ccgagctt                                                     18


<210> 96
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 96
tgattcgatg aaggtgattt cg                                                22


<210> 97
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 97
tgatgattgg acgctgcaa                                                    19


<210> 98
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 98
cattggccac atcgcttg                                                     18


<210> 99
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 99
accaaggcca aaacgacag                                                    19


<210> 100
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 100
gggctcacat tgttctactt ga                                                22


<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 101
ggcggagcat atgctgatcc                                                   20


<210> 102
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 102
ccacaggcac tagggaaggc                                                   20


<210> 103
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 103
tcaacctcgt cttcaagtgg att                                               23


<210> 104
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 104
ctgctttatt ataggcacgg agct                                              24


<210> 105
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 105
actgccacac ctccagtcat t                                                 21


<210> 106
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 106
ctttgcctca ctcaggattg g                                                 21


<210> 107
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 107
cggacaggat tgacagattg                                                   20


<210> 108
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 108
caaatcgctc caccaactaa                                                   20


