                               SEQUENCE LISTING

<110> ANVIL BIOSCIENCES, LLC 
 
<120> SERPINS FOR THE TREATMENT OF NEUROINFLAMMATORY DISEASES 

<130> ANV002W

<140>
<141>

<150> 62/131,073
<151> 2015-03-10

<160> 63    

<170> PatentIn version 3.5

<210> 1
<211> 418
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          


Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              


Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  


Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  


Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      


His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         


Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             


Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 


Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 


Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     


Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         


Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             


Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 


Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 


Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     


Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         


Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             


Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 


Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 


Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     


Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         


Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             


Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 


Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 


Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     


Gln Lys 
        


<210> 2
<211> 1257
<212> DNA
<213> Homo sapiens

<400> 2
atgccgtctt ctgtctcgtg gggcatcctc ctgctggcag gcctgtgctg cctggtccct       60

gtctccctgg ctgaggatcc ccagggagat gctgcccaga agacagatac atcccaccat      120

gatcaggatc acccaacctt caacaagatc acccccaacc tggctgagtt cgccttcagc      180

ctataccgcc agctggcaca ccagtccaac agcaccaata tcttcttctc cccagtgagc      240

atcgctacag cctttgcaat gctctccctg gggaccaagg ctgacactca cgatgaaatc      300

ctggagggcc tgaatttcaa cctcacggag attccggagg ctcagatcca tgaaggcttc      360

caggaactcc tccgtaccct caaccagcca gacagccagc tccagctgac caccggcaat      420

ggcctgttcc tcagcgaggg cctgaagcta gtggataagt ttttggagga tgttaaaaag      480

ttgtaccact cagaagcctt cactgtcaac ttcggggaca ccgaagaggc caagaaacag      540

atcaacgatt acgtggagaa gggtactcaa gggaaaattg tggatttggt caaggagctt      600

gacagagaca cagtttttgc tctggtgaat tacatcttct ttaaaggcaa atgggagaga      660

ccctttgaag tcaaggacac cgaggaagag gacttccacg tggaccaggt gaccaccgtg      720

aaggtgccta tgatgaagcg tttaggcatg tttaacatcc agcactgtaa gaagctgtcc      780

agctgggtgc tgctgatgaa atacctgggc aatgccaccg ccatcttctt cctgcctgat      840

gaggggaaac tacagcacct ggaaaatgaa ctcacccacg atatcatcac caagttcctg      900

gaaaatgaag acagaaggtc tgccagctta catttaccca aactgtccat tactggaacc      960

tatgatctga agagcgtcct gggtcaactg ggcatcacta aggtcttcag caatggggct     1020

gacctctccg gggtcacaga ggaggcaccc ctgaagctct ccaaggccgt gcataaggct     1080

gtgctgacca tcgacgagaa agggactgaa gctgctgggg ccatgttttt agaggccata     1140

cccatgtcta tcccccccga ggtcaagttc aacaaaccct ttgtcttctt aatgattgaa     1200

caaaatacca agtctcccct cttcatggga aaagtggtga atcccaccca aaaataa        1257


<210> 3
<211> 341
<212> PRT
<213> Cowpox virus

<400> 3
Met Asp Ile Phe Arg Glu Ile Ala Ser Ser Met Lys Gly Glu Asn Val 
1               5                   10                  15      


Phe Ile Ser Pro Pro Ser Ile Ser Ser Val Leu Thr Ile Leu Tyr Tyr 
            20                  25                  30          


Gly Ala Asn Gly Ser Thr Ala Glu Gln Leu Ser Lys Tyr Val Glu Lys 
        35                  40                  45              


Glu Ala Asp Lys Asn Lys Asp Asp Ile Ser Phe Lys Ser Met Asn Lys 
    50                  55                  60                  


Val Tyr Gly Arg Tyr Ser Ala Val Phe Lys Asp Ser Phe Leu Arg Lys 
65                  70                  75                  80  


Ile Gly Asp Asn Phe Gln Thr Val Asp Phe Thr Asp Cys Arg Thr Val 
                85                  90                  95      


Asp Ala Ile Asn Lys Cys Val Asp Ile Phe Thr Glu Gly Lys Ile Asn 
            100                 105                 110         


Pro Leu Leu Asp Glu Pro Leu Ser Pro Asp Thr Cys Leu Leu Ala Ile 
        115                 120                 125             


Ser Ala Val Tyr Phe Lys Ala Lys Trp Leu Met Pro Phe Glu Lys Glu 
    130                 135                 140                 


Phe Thr Ser Asp Tyr Pro Phe Tyr Val Ser Pro Thr Glu Met Val Asp 
145                 150                 155                 160 


Val Ser Met Met Ser Met Tyr Gly Glu Ala Phe Asn His Ala Ser Val 
                165                 170                 175     


Lys Glu Ser Phe Gly Asn Phe Ser Ile Ile Glu Leu Pro Tyr Val Gly 
            180                 185                 190         


Asp Thr Ser Met Val Val Ile Leu Pro Asp Asn Ile Asp Gly Leu Glu 
        195                 200                 205             


Ser Ile Glu Gln Asn Leu Thr Asp Thr Asn Phe Lys Lys Trp Cys Asp 
    210                 215                 220                 


Ser Met Asp Ala Met Phe Ile Asp Val His Ile Pro Lys Phe Lys Val 
225                 230                 235                 240 


Thr Gly Ser Tyr Asn Leu Val Asp Ala Leu Val Lys Leu Gly Leu Thr 
                245                 250                 255     


Glu Val Phe Gly Ser Thr Gly Asp Tyr Ser Asn Met Cys Asn Ser Asp 
            260                 265                 270         


Val Ser Val Asp Ala Met Ile His Lys Thr Tyr Ile Asp Val Asn Glu 
        275                 280                 285             


Glu Tyr Thr Glu Ala Ala Ala Ala Thr Cys Ala Leu Val Ala Asp Cys 
    290                 295                 300                 


Ala Ser Thr Val Thr Asn Glu Phe Cys Ala Asp His Pro Phe Ile Tyr 
305                 310                 315                 320 


Val Ile Arg His Val Asp Gly Lys Ile Leu Phe Val Gly Arg Tyr Cys 
                325                 330                 335     


Ser Pro Thr Thr Asn 
            340     


<210> 4
<211> 1026
<212> DNA
<213> Cowpox virus

<400> 4
atggatatct tcagggaaat cgcatcttct atgaaaggag agaatgtatt catttctcca       60

ccgtcaatct cgtcagtatt gacaatactg tattatggag ctaatggatc cactgctgaa      120

cagctatcaa aatatgtaga aaaggaggcg gacaagaata aggatgatat ctcattcaag      180

tccatgaata aagtatatgg gcgatattct gcagtgttta aagattcctt tttgagaaaa      240

attggagata atttccaaac tgttgacttc actgattgtc gcactgtaga tgcgatcaac      300

aagtgtgttg atatcttcac tgaggggaaa attaatccac tattggatga accattgtct      360

ccagatacct gtctcctagc aattagtgcc gtatacttta aagcaaaatg gttgatgcca      420

tttgaaaagg aatttaccag tgattatccc ttttacgtat ctccaacgga aatggtagat      480

gtaagtatga tgtctatgta cggcgaggca tttaatcacg catctgtaaa agaatcattc      540

ggcaactttt caatcataga actgccatat gttggagata ctagtatggt ggtaattctt      600

ccagacaata ttgatggact agaatccata gaacaaaatc taacagatac aaattttaag      660

aaatggtgtg actctatgga tgctatgttt atcgatgtgc acattcccaa gtttaaggta      720

acaggctcgt ataatctggt ggatgcgcta gtaaagttgg gactgacaga ggtgttcggt      780

tcaactggag attatagcaa tatgtgtaat tcagatgtga gtgtcgacgc tatgatccac      840

aaaacgtata tagatgtcaa tgaagagtat acagaagcag ctgcagcaac ttgtgcgctg      900

gtggcagact gtgcatcaac agttacaaat gagttctgtg cagatcatcc gttcatctat      960

gtgattaggc atgtcgatgg caaaattctt ttcgttggta gatattgctc tccaacaact     1020

aattaa                                                                1026


<210> 5
<211> 391
<212> PRT
<213> Arabidopsis thaliana

<400> 5
Met Asp Val Arg Glu Ser Ile Ser Leu Gln Asn Gln Val Ser Met Asn 
1               5                   10                  15      


Leu Ala Lys His Val Ile Thr Thr Val Ser Gln Asn Ser Asn Val Ile 
            20                  25                  30          


Phe Ser Pro Ala Ser Ile Asn Val Val Leu Ser Ile Ile Ala Ala Gly 
        35                  40                  45              


Ser Ala Gly Ala Thr Lys Asp Gln Ile Leu Ser Phe Leu Lys Phe Ser 
    50                  55                  60                  


Ser Thr Asp Gln Leu Asn Ser Phe Ser Ser Glu Ile Val Ser Ala Val 
65                  70                  75                  80  


Leu Ala Asp Gly Ser Ala Asn Gly Gly Pro Lys Leu Ser Val Ala Asn 
                85                  90                  95      


Gly Ala Trp Ile Asp Lys Ser Leu Ser Phe Lys Pro Ser Phe Lys Gln 
            100                 105                 110         


Leu Leu Glu Asp Ser Tyr Lys Ala Ala Ser Asn Gln Ala Asp Phe Gln 
        115                 120                 125             


Ser Lys Ala Val Glu Val Ile Ala Glu Val Asn Ser Trp Ala Glu Lys 
    130                 135                 140                 


Glu Thr Asn Gly Leu Ile Thr Glu Val Leu Pro Glu Gly Ser Ala Asp 
145                 150                 155                 160 


Ser Met Thr Lys Leu Ile Phe Ala Asn Ala Leu Tyr Phe Lys Gly Thr 
                165                 170                 175     


Trp Asn Glu Lys Phe Asp Glu Ser Leu Thr Gln Glu Gly Glu Phe His 
            180                 185                 190         


Leu Leu Asp Gly Asn Lys Val Thr Ala Pro Phe Met Thr Ser Lys Lys 
        195                 200                 205             


Lys Gln Tyr Val Ser Ala Tyr Asp Gly Phe Lys Val Leu Gly Leu Pro 
    210                 215                 220                 


Tyr Leu Gln Gly Gln Asp Lys Arg Gln Phe Ser Met Tyr Phe Tyr Leu 
225                 230                 235                 240 


Pro Asp Ala Asn Asn Gly Leu Ser Asp Leu Leu Asp Lys Ile Val Ser 
                245                 250                 255     


Thr Pro Gly Phe Leu Asp Asn His Ile Pro Arg Arg Gln Val Lys Val 
            260                 265                 270         


Arg Glu Phe Lys Ile Pro Lys Phe Lys Phe Ser Phe Gly Phe Asp Ala 
        275                 280                 285             


Ser Asn Val Leu Lys Gly Leu Gly Leu Thr Ser Pro Phe Ser Gly Glu 
    290                 295                 300                 


Glu Gly Leu Thr Glu Met Val Glu Ser Pro Glu Met Gly Lys Asn Leu 
305                 310                 315                 320 


Cys Val Ser Asn Ile Phe His Lys Ala Cys Ile Glu Val Asn Glu Glu 
                325                 330                 335     


Gly Thr Glu Ala Ala Ala Ala Ser Ala Gly Val Ile Lys Leu Arg Gly 
            340                 345                 350         


Leu Leu Met Glu Glu Asp Glu Ile Asp Phe Val Ala Asp His Pro Phe 
        355                 360                 365             


Leu Leu Val Val Thr Glu Asn Ile Thr Gly Val Val Leu Phe Ile Gly 
    370                 375                 380                 


Gln Val Val Asp Pro Leu His 
385                 390     


<210> 6
<211> 1446
<212> DNA
<213> Arabidopsis thaliana

<400> 6
cgtcttctcc taaacccagc aaattcgttt accagtcatc accaccacaa cctccggcga       60

aaatggacgt gcgtgaatca atctcactgc aaaaccaagt ctccatgaat ctcgcaaaac      120

acgtaatcac caccgtctct caaaactcca acgtcatctt ctcaccggct tcaatcaacg      180

tcgtactcag tataatcgcc gctggatccg ccggcgctac caaagatcag atcctctcgt      240

ttctcaaatt ctcttccact gatcaactta attcattctc ttccgaaatc gtctccgctg      300

ttctcgctga cggtagtgct aacggtggtc ctaagctctc ggtggctaat ggcgcctgga      360

tcgataagtc tctctccttt aaaccttcct ttaaacagct cttggaagat tcgtataaag      420

ctgcttcgaa tcaagctgat tttcaatcga aggctgtgga ggtgattgct gaagtgaatt      480

catgggctga aaaggagaca aatggtctca tcactgaggt tcttccagaa ggatcagctg      540

atagtatgac caaactgata tttgcaaatg cattgtactt caagggaaca tggaacgaga      600

aattcgatga gtcgttaaca caagaaggcg agtttcacct tcttgacggt aacaaagtga      660

ctgcaccatt catgaccagc aagaagaaac aatacgtaag tgcttacgat ggtttcaaag      720

ttttgggact tccttactta caaggacagg ataagcgaca attctccatg tacttttatc      780

ttcccgatgc aaacaacgga ctgtctgatc ttctggacaa aatagtttcc actcctgggt      840

tcttagacaa ccacatccca cgcagacaag ttaaagtccg cgaattcaag attccaaagt      900

ttaaattctc tttcgggttc gatgcttcaa atgttttaaa aggattggga ctgacttcgc      960

ctttcagcgg tgaagaaggt ttaactgaga tggttgaatc tcctgagatg gggaagaatc     1020

tatgcgtatc gaacattttc cataaagcgt gtatcgaagt gaatgaagaa ggaacagaag     1080

ctgcagctgc atcagctgga gttataaagc taagaggatt gcttatggag gaagatgaaa     1140

tagattttgt tgcagaccat ccgtttctat tggtggtcac agagaacata acaggagtgg     1200

ttctgttcat tggccaagtt gttgatccgt tgcattaatc taaagctaat gtggaagttt     1260

ttggttttac ttaaaataaa tgagtcattg gttttgagga ctcatcttta tgtaacatcc     1320

tttgtcttga ctctttgatg tgtgtaagaa taatagtgat acataacagc ttttcttctg     1380

tatttggatc acatgtactg aactgataga catacataca tgtgatgcat cttaatgatt     1440

cactgt                                                                1446


<210> 7
<211> 376
<212> PRT
<213> Homo sapiens

<400> 7
Met Glu Thr Leu Ser Asn Ala Ser Gly Thr Phe Ala Ile Arg Leu Leu 
1               5                   10                  15      


Lys Ile Leu Cys Gln Asp Asn Pro Ser His Asn Val Phe Cys Ser Pro 
            20                  25                  30          


Val Ser Ile Ser Ser Ala Leu Ala Met Val Leu Leu Gly Ala Lys Gly 
        35                  40                  45              


Asn Thr Ala Thr Gln Met Ala Gln Ala Leu Ser Leu Asn Thr Glu Glu 
    50                  55                  60                  


Asp Ile His Arg Ala Phe Gln Ser Leu Leu Thr Glu Val Asn Lys Ala 
65                  70                  75                  80  


Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                85                  90                  95      


Thr Cys Gln Phe Leu Ser Thr Phe Lys Glu Ser Cys Leu Gln Phe Tyr 
            100                 105                 110         


His Ala Glu Leu Lys Glu Leu Ser Phe Ile Arg Ala Ala Glu Glu Ser 
        115                 120                 125             


Arg Lys His Ile Asn Thr Trp Val Ser Lys Lys Thr Glu Gly Lys Ile 
    130                 135                 140                 


Glu Glu Leu Leu Pro Gly Ser Ser Ile Asp Ala Glu Thr Arg Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Pro Phe Asp 
                165                 170                 175     


Glu Thr Tyr Thr Arg Glu Met Pro Phe Lys Ile Asn Gln Glu Glu Gln 
            180                 185                 190         


Arg Pro Val Gln Met Met Tyr Gln Glu Ala Thr Phe Lys Leu Ala His 
        195                 200                 205             


Val Gly Glu Val Arg Ala Gln Leu Leu Glu Leu Pro Tyr Ala Arg Lys 
    210                 215                 220                 


Glu Leu Ser Leu Leu Val Leu Leu Pro Asp Asp Gly Val Glu Leu Ser 
225                 230                 235                 240 


Thr Val Glu Lys Ser Leu Thr Phe Glu Lys Leu Thr Ala Trp Thr Lys 
                245                 250                 255     


Pro Asp Cys Met Lys Ser Thr Glu Val Glu Val Leu Leu Pro Lys Phe 
            260                 265                 270         


Lys Leu Gln Glu Asp Tyr Asp Met Glu Ser Val Leu Arg His Leu Gly 
        275                 280                 285             


Ile Val Asp Ala Phe Gln Gln Gly Lys Ala Asp Leu Ser Ala Met Ser 
    290                 295                 300                 


Ala Glu Arg Asp Leu Cys Leu Ser Lys Phe Val His Lys Ser Phe Val 
305                 310                 315                 320 


Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Ser Ser Cys Phe 
                325                 330                 335     


Val Val Ala Glu Cys Cys Met Glu Ser Gly Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Arg His Asn Arg Ala Asn Ser Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 8
<211> 1068
<212> DNA
<213> Homo sapiens

<400> 8
atggaaactc tttctaatgc aagtggtact tttgccatac gccttttaaa gatactgtgt       60

caagataacc cttcgcacaa cgtgttctgt tctcctgtga gcatctcctc tgccctggcc      120

atggttctcc taggggcaaa gggaaacacc gcaacccaga tggcccaggc actgtcttta      180

aacacagagg aagacattca tcgggctttc cagtcgcttc tcactgaagt gaacaaggct      240

ggcacacagt acctgctgag aacggccaac aggctctttg gagagaaaac ttgtcagttc      300

ctctcaacgt ttaaggaatc ctgtcttcaa ttctaccatg ctgagctgaa ggagctttcc      360

tttatcagag ctgcagaaga gtccaggaaa cacatcaaca cctgggtctc aaaaaagacc      420

gaaggtaaaa ttgaagagtt gttgccgggt agctcaattg atgcagaaac caggctggtt      480

cttgtcaatg ccatctactt caaaggaaag tggaatgaac cgtttgacga aacatacaca      540

agggaaatgc cctttaaaat aaaccaggag gagcaaaggc cagtgcagat gatgtatcag      600

gaggccacgt ttaagctcgc ccacgtgggc gaggtgcgcg cgcagctgct ggagctgccc      660

tacgccagga aggagctgag cctgctggtg ctgctgcctg acgacggcgt ggagctcagc      720

aagagtactg aggttgaagt tctccttcca aaatttaaac tacaagagga ttatgacatg      780

gaatctgtgc ttcggcattt gggaattgtt gatgccttcc aacagggcaa ggctgacttg      840

tcggcaatgt cagcggagag agacctgtgt ctgtccaagt tcgtgcacaa gagttttgtg      900

gaggtgaatg aagaaggcac cgaggcagcg gcagcgtcga gctgctttgt agttgcagag      960

tgctgcatgg aatctggccc caggttctgt gctgaccacc ctttcctttt cttcatcagg     1020

cacaacagag ccaacagcat tctgttctgt ggcaggttct catcgcca                  1068


<210> 9
<211> 95
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Arg Met Leu Pro Leu Leu Thr Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Ser 
    50                  55                  60                  


Pro Arg Trp Ser Ile Arg Leu Cys Leu Met Tyr Leu Arg Arg Ala Gln 
65                  70                  75                  80  


Lys His Leu Leu Pro Gln Gln Ser Lys Ser Pro Ser Phe Leu His 
                85                  90                  95  


<210> 10
<211> 423
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Arg Met Leu Pro Leu Leu Ala Leu Gly Leu Leu Ala Ala Gly 
1               5                   10                  15      


Phe Cys Pro Ala Val Leu Cys His Pro Asn Ser Pro Leu Asp Glu Glu 
            20                  25                  30          


Asn Leu Thr Gln Glu Asn Gln Asp Arg Gly Thr His Val Asp Leu Gly 
        35                  40                  45              


Leu Ala Ser Ala Asn Val Asp Phe Ala Phe Ser Leu Tyr Lys Gln Leu 
    50                  55                  60                  


Val Leu Lys Ala Pro Asp Lys Asn Val Ile Phe Ser Pro Leu Ser Ile 
65                  70                  75                  80  


Ser Thr Ala Leu Ala Phe Leu Ser Leu Gly Ala His Asn Thr Thr Leu 
                85                  90                  95      


Thr Glu Ile Leu Lys Gly Leu Lys Phe Asn Leu Thr Glu Thr Ser Glu 
            100                 105                 110         


Ala Glu Ile His Gln Ser Phe Gln His Leu Leu Arg Thr Leu Asn Gln 
        115                 120                 125             


Ser Ser Asp Glu Leu Gln Leu Ser Met Gly Asn Ala Met Phe Val Lys 
    130                 135                 140                 


Glu Gln Leu Ser Leu Leu Asp Arg Phe Thr Glu Asp Ala Lys Arg Leu 
145                 150                 155                 160 


Tyr Gly Ser Glu Ala Phe Ala Thr Asp Phe Gln Asp Ser Ala Ala Ala 
                165                 170                 175     


Lys Lys Leu Ile Asn Asp Tyr Val Lys Asn Gly Thr Arg Gly Lys Ile 
            180                 185                 190         


Thr Asp Leu Ile Lys Asp Leu Asp Ser Gln Thr Met Met Val Leu Val 
        195                 200                 205             


Asn Tyr Ile Phe Phe Lys Ala Lys Trp Glu Met Pro Phe Asp Pro Gln 
    210                 215                 220                 


Asp Thr His Gln Ser Arg Phe Tyr Leu Ser Lys Lys Lys Trp Val Met 
225                 230                 235                 240 


Val Pro Met Met Ser Leu His His Leu Thr Ile Pro Tyr Phe Arg Asp 
                245                 250                 255     


Glu Glu Leu Ser Cys Thr Val Val Glu Leu Lys Tyr Thr Gly Asn Ala 
            260                 265                 270         


Ser Ala Leu Phe Ile Leu Pro Asp Gln Asp Lys Met Glu Glu Val Glu 
        275                 280                 285             


Ala Met Leu Leu Pro Glu Thr Leu Lys Arg Trp Arg Asp Ser Leu Glu 
    290                 295                 300                 


Phe Arg Glu Ile Gly Glu Leu Tyr Leu Pro Lys Phe Ser Ile Ser Arg 
305                 310                 315                 320 


Asp Tyr Asn Leu Asn Asp Ile Leu Leu Gln Leu Gly Ile Glu Glu Ala 
                325                 330                 335     


Phe Thr Ser Lys Ala Asp Leu Ser Gly Ile Thr Gly Ala Arg Asn Leu 
            340                 345                 350         


Ala Val Ser Gln Val Val His Lys Ala Val Leu Asp Val Phe Glu Glu 
        355                 360                 365             


Gly Thr Glu Ala Ser Ala Ala Thr Ala Val Lys Ile Thr Leu Leu Ser 
    370                 375                 380                 


Ala Leu Val Glu Thr Arg Thr Ile Val Arg Phe Asn Arg Pro Phe Leu 
385                 390                 395                 400 


Met Ile Ile Val Pro Thr Asp Thr Gln Asn Ile Phe Phe Met Ser Lys 
                405                 410                 415     


Val Thr Asn Pro Lys Gln Ala 
            420             


<210> 11
<211> 1272
<212> DNA
<213> Homo sapiens

<400> 11
atggagagaa tgttacctct cctggctctg gggctcttgg cggctgggtt ctgccctgct       60

gtcctctgcc accctaacag cccacttgac gaggagaatc tgacccagga gaaccaagac      120

cgagggacac acgtggacct cggattagcc tccgccaacg tggacttcgc tttcagcctg      180

tacaagcagt tagtcctgaa ggcccctgat aagaatgtca tcttctcccc actgagcatc      240

tccaccgcct tggccttcct gtctctgggg gcccataata ccaccctgac agagattctc      300

aaaggcctca agttcaacct cacggagact tctgaggcag aaattcacca gagcttccag      360

cacctcctgc gcaccctcaa tcagtccagc gatgagctgc agctgagtat gggaaatgcc      420

atgtttgtca aagagcaact cagtctgctg gacaggttca cggaggatgc caagaggctg      480

tatggctccg aggcctttgc cactgacttt caggactcag ctgcagctaa gaagctcatc      540

aacgactacg tgaagaatgg aactaggggg aaaatcacag atctgatcaa ggaccttgac      600

tcgcagacaa tgatggtcct ggtgaattac atcttcttta aagccaaatg ggagatgccc      660

tttgaccccc aagatactca tcagtcaagg ttctacttga gcaagaaaaa gtgggtaatg      720

gtgcccatga tgagtttgca tcacctgact ataccttact tccgggacga ggagctgtcc      780

tgcaccgtgg tggagctgaa gtacacaggc aatgccagcg cactcttcat cctccctgat      840

caagacaaga tggaggaagt ggaagccatg ctgctcccag agaccctgaa gcggtggaga      900

gactctctgg agttcagaga gataggtgag ctctacctgc caaagttttc catctcgagg      960

gactataacc tgaacgacat acttctccag ctgggcattg aggaagcctt caccagcaag     1020

gctgacctgt cagggatcac aggggccagg aacctagcag tctcccaggt ggtccataag     1080

gctgtgcttg atgtatttga ggagggcaca gaagcatctg ctgccacagc agtcaaaatc     1140

accctccttt ctgcattagt ggagacaagg accattgtgc gtttcaacag gcccttcctg     1200

atgatcattg tccctacaga cacccagaac atcttcttca tgagcaaagt caccaatccc     1260

aagcaagcct ag                                                         1272


<210> 12
<211> 427
<212> PRT
<213> Homo sapiens

<400> 12
Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu Val Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser His Gly Gln Leu His Val Glu His Asp Gly Glu Ser Cys Ser 
            20                  25                  30          


Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly Glu Gly Ser Pro Ser 
        35                  40                  45              


Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala Phe Arg Phe Tyr Tyr 
    50                  55                  60                  


Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile Phe Phe Ser Pro Leu 
65                  70                  75                  80  


Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu Gly Ala Cys Ser His 
                85                  90                  95      


Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr Glu Leu 
            100                 105                 110         


Ser Glu Ser Asp Val His Arg Gly Phe Gln His Leu Leu His Thr Leu 
        115                 120                 125             


Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val Gly Ser Ala Leu Phe 
    130                 135                 140                 


Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe Leu Asn Asp Thr Met 
145                 150                 155                 160 


Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn Phe Tyr Asp Thr Val 
                165                 170                 175     


Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys Lys Glu Thr Arg Gly 
            180                 185                 190         


Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys Asp Val Leu Met Val 
        195                 200                 205             


Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp Glu Lys Pro Phe Ile 
    210                 215                 220                 


Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val Asp Glu Asn Thr Thr 
225                 230                 235                 240 


Val Arg Val Pro Met Met Leu Gln Asp Gln Glu His His Trp Tyr Leu 
                245                 250                 255     


His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg Met Asp Tyr Lys Gly 
            260                 265                 270         


Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln Gly Lys Met Arg Glu 
        275                 280                 285             


Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met Arg Trp Asn Asn Leu 
    290                 295                 300                 


Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu Leu His Leu Pro Lys 
305                 310                 315                 320 


Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln Ile Leu Pro Arg Leu 
                325                 330                 335     


Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp Leu Ser Gly Ile Thr 
            340                 345                 350         


Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe His Lys Ala Thr Leu 
        355                 360                 365             


Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala Ala Thr Ser Phe Ala 
    370                 375                 380                 


Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn 
385                 390                 395                 400 


Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln Ser Val Leu 
                405                 410                 415     


Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro 
            420                 425         


<210> 13
<211> 1284
<212> DNA
<213> Homo sapiens

<400> 13
atgcatctta tcgactacct gctcctcctg ctggttggac tactggccct ttctcatggc       60

cagctgcacg ttgagcatga tggtgagagt tgcagtaaca gctcccacca gcagattctg      120

gagacaggtg agggctcccc cagcctcaag atagcccctg ccaatgctga ctttgccttc      180

cgcttctact acctgatcgc ttcggagacc ccggggaaga acatcttttt ctccccgctg      240

agcatctcgg cggcctacgc catgctttcc ctgggggcct gctcacacag ccgcagccag      300

atccttgagg gcctgggctt caacctcacc gagctgtctg agtccgatgt ccataggggc      360

ttccagcacc tcctgcacac tctcaacctc cccggccatg ggctggaaac acgcgtgggc      420

agtgctctgt tcctgagcca caacctgaag ttccttgcaa aattcctgaa tgacaccatg      480

gccgtctatg aggctaaact cttccacacc aacttctacg acactgtggg cacaatccag      540

cttatcaacg accacgtcaa gaaggaaact cgagggaaga ttgtggattt ggtcagtgag      600

ctcaagaagg acgtcttgat ggtgctggtg aattacattt acttcaaagc cctgtgggag      660

aaaccattca tttcctcaag gaccactccc aaagacttct atgttgatga gaacacaaca      720

gtccgggtgc ccatgatgct gcaggaccag gagcatcact ggtatcttca tgacagatac      780

ttgccctgct cggtgctacg gatggattac aaaggagacg caaccgtgtt tttcattctc      840

cctaaccaag gcaaaatgag ggagattgaa gaggttctga ctccagagat gctaatgagg      900

tggaacaact tgttgcggaa gaggaatttt tacaagaagc tagagttgca tcttcccaag      960

ttctccattt ctggctccta tgtattagat cagattttgc ccaggctggg cttcacggat     1020

ctgttctcca agtgggctga cttatccggc atcaccaaac agcaaaaact ggaggcatcc     1080

aaaagtttcc acaaggccac cttggacgtg gatgaggctg gcaccgaggc tgcagcagcc     1140

accagcttcg cgatcaaatt cttctctgcc cagaccaatc gccacatcct gcgattcaac     1200

cggcccttcc ttgtggtgat cttttccacc agcacccaga gtgtcctctt tctgggcaag     1260

gtcgtcgacc ccacgaaacc atag                                            1284


<210> 14
<211> 427
<212> PRT
<213> Homo sapiens

<400> 14
Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu Val Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser His Gly Gln Leu His Val Glu His Asp Gly Glu Ser Cys Ser 
            20                  25                  30          


Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly Glu Gly Ser Pro Ser 
        35                  40                  45              


Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala Phe Arg Phe Tyr Tyr 
    50                  55                  60                  


Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile Phe Phe Ser Pro Leu 
65                  70                  75                  80  


Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu Gly Ala Cys Ser His 
                85                  90                  95      


Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr Glu Leu 
            100                 105                 110         


Ser Glu Ser Asp Val His Arg Gly Phe Gln His Leu Leu His Thr Leu 
        115                 120                 125             


Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val Gly Ser Ala Leu Phe 
    130                 135                 140                 


Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe Leu Asn Asp Thr Met 
145                 150                 155                 160 


Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn Phe Tyr Asp Thr Val 
                165                 170                 175     


Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys Lys Glu Thr Arg Gly 
            180                 185                 190         


Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys Asp Val Leu Met Val 
        195                 200                 205             


Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp Glu Lys Pro Phe Ile 
    210                 215                 220                 


Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val Asp Glu Asn Thr Thr 
225                 230                 235                 240 


Val Arg Val Pro Met Met Leu Gln Asp Gln Glu His His Trp Tyr Leu 
                245                 250                 255     


His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg Met Asp Tyr Lys Gly 
            260                 265                 270         


Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln Gly Lys Met Arg Glu 
        275                 280                 285             


Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met Arg Trp Asn Asn Leu 
    290                 295                 300                 


Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu Leu His Leu Pro Lys 
305                 310                 315                 320 


Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln Ile Leu Pro Arg Leu 
                325                 330                 335     


Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp Leu Ser Gly Ile Thr 
            340                 345                 350         


Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe His Lys Ala Thr Leu 
        355                 360                 365             


Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala Ala Thr Ser Phe Ala 
    370                 375                 380                 


Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn 
385                 390                 395                 400 


Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln Ser Val Leu 
                405                 410                 415     


Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro 
            420                 425         


<210> 15
<211> 1284
<212> DNA
<213> Homo sapiens

<400> 15
atgcatctta tcgactacct gctcctcctg ctggttggac tactggccct ttctcatggc       60

cagctgcacg ttgagcatga tggtgagagt tgcagtaaca gctcccacca gcagattctg      120

gagacaggtg agggctcccc cagcctcaag atagcccctg ccaatgctga ctttgccttc      180

cgcttctact acctgatcgc ttcggagacc ccggggaaga acatcttttt ctccccgctg      240

agcatctcgg cggcctacgc catgctttcc ctgggggcct gctcacacag ccgcagccag      300

atccttgagg gcctgggctt caacctcacc gagctgtctg agtccgatgt ccataggggc      360

ttccagcacc tcctgcacac tctcaacctc cccggccatg ggctggaaac acgcgtgggc      420

agtgctctgt tcctgagcca caacctgaag ttccttgcaa aattcctgaa tgacaccatg      480

gccgtctatg aggctaaact cttccacacc aacttctacg acactgtggg cacaatccag      540

cttatcaacg accacgtcaa gaaggaaact cgagggaaga ttgtggattt ggtcagtgag      600

ctcaagaagg acgtcttgat ggtgctggtg aattacattt acttcaaagc cctgtgggag      660

aaaccattca tttcctcaag gaccactccc aaagacttct atgttgatga gaacacaaca      720

gtccgggtgc ccatgatgct gcaggaccag gagcatcact ggtatcttca tgacagatac      780

ttgccctgct cggtgctacg gatggattac aaaggagacg caaccgtgtt tttcattctc      840

cctaaccaag gcaaaatgag ggagattgaa gaggttctga ctccagagat gctaatgagg      900

tggaacaact tgttgcggaa gaggaatttt tacaagaagc tagagttgca tcttcccaag      960

ttctccattt ctggctccta tgtattagat cagattttgc ccaggctggg cttcacggat     1020

ctgttctcca agtgggctga cttatccggc atcaccaaac agcaaaaact ggaggcatcc     1080

aaaagtttcc acaaggccac cttggacgtg gatgaggctg gcaccgaggc tgcagcagcc     1140

accagcttcg cgatcaaatt cttctctgcc cagaccaatc gccacatcct gcgattcaac     1200

cggcccttcc ttgtggtgat cttttccacc agcacccaga gtgtcctctt tctgggcaag     1260

gtcgtcgacc ccacgaaacc atag                                            1284


<210> 16
<211> 464
<212> PRT
<213> Homo sapiens

<400> 16
Met Pro Gly Asp Pro Glu Lys Pro Pro Pro Gly Thr His Ser Trp Tyr 
1               5                   10                  15      


Arg Ala Ala Leu Thr Glu Gly Gln Gly Leu Leu Ala Ala Asn Pro Gly 
            20                  25                  30          


Leu Arg Val Gln Arg Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu 
        35                  40                  45              


Val Gly Leu Leu Ala Leu Ser His Gly Gln Leu His Val Glu His Asp 
    50                  55                  60                  


Gly Glu Ser Cys Ser Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly 
65                  70                  75                  80  


Glu Gly Ser Pro Ser Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala 
                85                  90                  95      


Phe Arg Phe Tyr Tyr Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile 
            100                 105                 110         


Phe Phe Ser Pro Leu Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu 
        115                 120                 125             


Gly Ala Cys Ser His Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe 
    130                 135                 140                 


Asn Leu Thr Glu Leu Ser Glu Ser Asp Val His Arg Gly Phe Gln His 
145                 150                 155                 160 


Leu Leu His Thr Leu Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val 
                165                 170                 175     


Gly Ser Ala Leu Phe Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe 
            180                 185                 190         


Leu Asn Asp Thr Met Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn 
        195                 200                 205             


Phe Tyr Asp Thr Val Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys 
    210                 215                 220                 


Lys Glu Thr Arg Gly Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys 
225                 230                 235                 240 


Asp Val Leu Met Val Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp 
                245                 250                 255     


Glu Lys Pro Phe Ile Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val 
            260                 265                 270         


Asp Glu Asn Thr Thr Val Arg Val Pro Met Met Leu Gln Asp Gln Glu 
        275                 280                 285             


His His Trp Tyr Leu His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg 
    290                 295                 300                 


Met Asp Tyr Lys Gly Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln 
305                 310                 315                 320 


Gly Lys Met Arg Glu Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met 
                325                 330                 335     


Arg Trp Asn Asn Leu Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu 
            340                 345                 350         


Leu His Leu Pro Lys Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln 
        355                 360                 365             


Ile Leu Pro Arg Leu Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp 
    370                 375                 380                 


Leu Ser Gly Ile Thr Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe 
385                 390                 395                 400 


His Lys Ala Thr Leu Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala 
                405                 410                 415     


Ala Thr Ser Phe Ala Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His 
            420                 425                 430         


Ile Leu Arg Phe Asn Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser 
        435                 440                 445             


Thr Gln Ser Val Leu Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro 
    450                 455                 460                 


<210> 17
<211> 1395
<212> DNA
<213> Homo sapiens

<400> 17
atgcccggag acccagaaaa gcctccccca gggacacaca gctggtacag ggcggcactg       60

actgagggcc aaggtcttct ggctgccaat ccaggcctga gagtgcagag gatgcatctt      120

atcgactacc tgctcctcct gctggttgga ctactggccc tttctcatgg ccagctgcac      180

gttgagcatg atggtgagag ttgcagtaac agctcccacc agcagattct ggagacaggt      240

gagggctccc ccagcctcaa gatagcccct gccaatgctg actttgcctt ccgcttctac      300

tacctgatcg cttcggagac cccggggaag aacatctttt tctccccgct gagcatctcg      360

gcggcctacg ccatgctttc cctgggggcc tgctcacaca gccgcagcca gatccttgag      420

ggcctgggct tcaacctcac cgagctgtct gagtccgatg tccatagggg cttccagcac      480

ctcctgcaca ctctcaacct ccccggccat gggctggaaa cacgcgtggg cagtgctctg      540

ttcctgagcc acaacctgaa gttccttgca aaattcctga atgacaccat ggccgtctat      600

gaggctaaac tcttccacac caacttctac gacactgtgg gcacaatcca gcttatcaac      660

gaccacgtca agaaggaaac tcgagggaag attgtggatt tggtcagtga gctcaagaag      720

gacgtcttga tggtgctggt gaattacatt tacttcaaag ccctgtggga gaaaccattc      780

atttcctcaa ggaccactcc caaagacttc tatgttgatg agaacacaac agtccgggtg      840

cccatgatgc tgcaggacca ggagcatcac tggtatcttc atgacagata cttgccctgc      900

tcggtgctac ggatggatta caaaggagac gcaaccgtgt ttttcattct ccctaaccaa      960

ggcaaaatga gggagattga agaggttctg actccagaga tgctaatgag gtggaacaac     1020

ttgttgcgga agaggaattt ttacaagaag ctagagttgc atcttcccaa gttctccatt     1080

tctggctcct atgtattaga tcagattttg cccaggctgg gcttcacgga tctgttctcc     1140

aagtgggctg acttatccgg catcaccaaa cagcaaaaac tggaggcatc caaaagtttc     1200

cacaaggcca ccttggacgt ggatgaggct ggcaccgagg ctgcagcagc caccagcttc     1260

gcgatcaaat tcttctctgc ccagaccaat cgccacatcc tgcgattcaa ccggcccttc     1320

cttgtggtga tcttttccac cagcacccag agtgtcctct ttctgggcaa ggtcgtcgac     1380

cccacgaaac catag                                                      1395


<210> 18
<211> 406
<212> PRT
<213> Homo sapiens

<400> 18
Met Gln Leu Phe Leu Leu Leu Cys Leu Val Leu Leu Ser Pro Gln Gly 
1               5                   10                  15      


Ala Ser Leu His Arg His His Pro Arg Glu Met Lys Lys Arg Val Glu 
            20                  25                  30          


Asp Leu His Val Gly Ala Thr Val Ala Pro Ser Ser Arg Arg Asp Phe 
        35                  40                  45              


Thr Phe Asp Leu Tyr Arg Ala Leu Ala Ser Ala Ala Pro Ser Gln Ser 
    50                  55                  60                  


Ile Phe Phe Ser Pro Val Ser Ile Ser Met Ser Leu Ala Met Leu Ser 
65                  70                  75                  80  


Leu Gly Ala Gly Ser Ser Thr Lys Met Gln Ile Leu Glu Gly Leu Gly 
                85                  90                  95      


Leu Asn Leu Gln Lys Ser Ser Glu Lys Glu Leu His Arg Gly Phe Gln 
            100                 105                 110         


Gln Leu Leu Gln Glu Leu Asn Gln Pro Arg Asp Gly Phe Gln Leu Ser 
        115                 120                 125             


Leu Gly Asn Ala Leu Phe Thr Asp Leu Val Val Asp Leu Gln Asp Thr 
    130                 135                 140                 


Phe Val Ser Ala Met Lys Thr Leu Tyr Leu Ala Asp Thr Phe Pro Thr 
145                 150                 155                 160 


Asn Phe Arg Asp Ser Ala Gly Ala Met Lys Gln Ile Asn Asp Tyr Val 
                165                 170                 175     


Ala Lys Gln Thr Lys Gly Lys Ile Val Asp Leu Leu Lys Asn Leu Asp 
            180                 185                 190         


Ser Asn Ala Val Val Ile Met Val Asn Tyr Ile Phe Phe Lys Ala Lys 
        195                 200                 205             


Trp Glu Thr Ser Phe Asn His Lys Gly Thr Gln Glu Gln Asp Phe Tyr 
    210                 215                 220                 


Val Thr Ser Glu Thr Val Val Arg Val Pro Met Met Ser Arg Glu Asp 
225                 230                 235                 240 


Gln Tyr His Tyr Leu Leu Asp Arg Asn Leu Ser Cys Arg Val Val Gly 
                245                 250                 255     


Val Pro Tyr Gln Gly Asn Ala Thr Ala Leu Phe Ile Leu Pro Ser Glu 
            260                 265                 270         


Gly Lys Met Gln Gln Val Glu Asn Gly Leu Ser Glu Lys Thr Leu Arg 
        275                 280                 285             


Lys Trp Leu Lys Met Phe Lys Lys Arg Gln Leu Glu Leu Tyr Leu Pro 
    290                 295                 300                 


Lys Phe Ser Ile Glu Gly Ser Tyr Gln Leu Glu Lys Val Leu Pro Ser 
305                 310                 315                 320 


Leu Gly Ile Ser Asn Val Phe Thr Ser His Ala Asp Leu Ser Gly Ile 
                325                 330                 335     


Ser Asn His Ser Asn Ile Gln Val Ser Glu Met Val His Lys Ala Val 
            340                 345                 350         


Val Glu Val Asp Glu Ser Gly Thr Arg Ala Ala Ala Ala Thr Gly Thr 
        355                 360                 365             


Ile Phe Thr Phe Arg Ser Ala Arg Leu Asn Ser Gln Arg Leu Val Phe 
    370                 375                 380                 


Asn Arg Pro Phe Leu Met Phe Ile Val Asp Asn Asn Ile Leu Phe Leu 
385                 390                 395                 400 


Gly Lys Val Asn Arg Pro 
                405     


<210> 19
<211> 1221
<212> DNA
<213> Homo sapiens

<400> 19
atgcagctct tcctcctctt gtgcctggtg cttctcagcc ctcagggggc ctcccttcac       60

cgccaccacc cccgggagat gaagaagaga gtcgaggacc tccatgtagg tgccacggtg      120

gcccccagca gcagaaggga ctttaccttt gacctctaca gggccttggc ttccgctgcc      180

cccagccaga gcatcttctt ctcccctgtg agcatctcca tgagcctggc catgctctcc      240

ctgggggctg ggtccagcac aaagatgcag atcctggagg gcctgggcct caacctccag      300

aaaagctcag agaaggagct gcacagaggc tttcagcagc tccttcagga actcaaccag      360

cccagagatg gcttccagct gagcctcggc aatgcccttt tcaccgacct ggtggtagac      420

ctgcaggaca ccttcgtaag tgccatgaag acgctgtacc tggcagacac tttccctacc      480

aactttaggg actctgcagg ggccatgaag cagatcaatg attatgtggc aaagcaaacg      540

aagggcaaga ttgtggactt gcttaagaac ctcgatagca atgcggtcgt gatcatggtg      600

aattacatct tctttaaagc taagtgggag acaagcttca accacaaagg cacccaagag      660

caagacttct acgtgacctc ggagactgtg gtgcgggtac ccatgatgag ccgcgaggat      720

cagtatcact acctcctgga ccggaacctc tcctgcaggg tggtgggggt cccctaccaa      780

ggcaatgcca cggctttgtt cattctcccc agtgagggaa agatgcagca ggtggagaat      840

ggactgagtg agaaaacgct gaggaagtgg cttaagatgt tcaaaaagag gcagctcgag      900

ctttaccttc ccaaattctc cattgagggc tcctatcagc tggagaaagt cctccccagt      960

ctggggatca gtaacgtctt cacctcccat gctgatctgt ccggcatcag caaccactca     1020

aatatccagg tgtctgagat ggtgcacaaa gctgtggtgg aggtggacga gtcgggaacc     1080

agagcagcgg cagccacggg gacaatattc actttcaggt cggcccgcct gaactctcag     1140

aggctagtgt tcaacaggcc ctttctgatg ttcattgtgg ataacaacat cctcttcctt     1200

ggcaaagtga accgcccctg a                                               1221


<210> 20
<211> 286
<212> PRT
<213> Homo sapiens

<400> 20
Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu Gln Leu Gln Ala Asn 
1               5                   10                  15      


Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala Glu Val Phe Ser Thr 
            20                  25                  30          


Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg Ile Asn Ser His Val 
        35                  40                  45              


Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile Ile Gln Gly Leu Asp 
    50                  55                  60                  


Leu Leu Thr Ala Met Val Leu Val Asn His Ile Phe Phe Lys Ala Lys 
65                  70                  75                  80  


Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg Lys Asn Phe Pro Phe 
                85                  90                  95      


Leu Val Gly Glu Gln Val Thr Val His Val Pro Met Met His Gln Lys 
            100                 105                 110         


Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu Asn Cys Phe Val Leu 
        115                 120                 125             


Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe Phe Val Leu Pro Ser 
    130                 135                 140                 


Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu Ser Ala Arg Thr Leu 
145                 150                 155                 160 


Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp Ile Glu Val Phe Ile 
                165                 170                 175     


Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu Glu Thr Ile Leu Pro 
            180                 185                 190         


Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn Ala Asp Phe Ser Gly 
        195                 200                 205             


Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys Ala Thr His Lys Ala 
    210                 215                 220                 


Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Thr Ala Ala Thr Thr 
225                 230                 235                 240 


Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr Val 
                245                 250                 255     


Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr Asn Lys Ala Thr Asp 
            260                 265                 270         


Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro Thr Lys Ser 
        275                 280                 285     


<210> 21
<211> 861
<212> DNA
<213> Homo sapiens

<400> 21
atgggaagtg ccctcttcgt caagaaggag ctgcagctgc aggcaaattt cttgggcaat       60

gtcaagaggc tgtatgaagc agaagtcttt tctacagatt tctccaaccc ctccattgcc      120

caggcgagga tcaacagcca tgtgaaaaag aagacccaag ggaaggttgt agacataatc      180

caaggccttg accttctgac ggccatggtt ctggtgaacc acattttctt taaagccaag      240

tgggagaagc cctttcaccc tgaatataca agaaagaact tcccattcct ggtgggcgag      300

caggtcactg tgcatgtccc catgatgcac cagaaagagc agttcgcttt tggggtggat      360

acagagctga actgctttgt gctgcagatg gattacaagg gagatgccgt ggccttcttt      420

gtcctcccta gcaagggcaa gatgaggcaa ctggaacagg ccttgtcagc cagaacactg      480

agaaagtgga gccactcact ccagaaaagg tggatagagg tgttcatccc cagattttcc      540

atttctgcct cctacaatct ggaaaccatc ctcccgaaga tgggcatcca aaatgtcttt      600

gacaaaaatg ctgatttttc tggaattgca aagagagact ccctgcaggt ttctaaagca      660

acccacaagg ctgtgctgga tgtcagtgaa gagggcactg aggccacagc agctaccacc      720

accaagttca tagtccgatc gaaggatggc ccctcttact tcactgtctc cttcaatagg      780

accttcctga tgatgattac aaataaagcc acagacggta ttctctttct agggaaagtg      840

gaaaatccca ctaaatccta g                                                861


<210> 22
<211> 399
<212> PRT
<213> Homo sapiens

<400> 22
Met Arg Ser Ala Gly Gly Arg Gly Glu Ile Lys Val Arg Arg Glu Leu 
1               5                   10                  15      


Gln Pro Ser Lys Gln Val Ser Gly Leu Thr Asn His Ala Arg Thr Gly 
            20                  25                  30          


Gln Glu Lys Arg Asn Leu Gln Arg Leu Val Leu Glu Thr Pro Ser Gln 
        35                  40                  45              


Asn Ile Phe Phe Ser Pro Val Ser Val Ser Thr Ser Leu Ala Met Leu 
    50                  55                  60                  


Ser Leu Gly Ala His Ser Val Thr Lys Thr Gln Ile Leu Gln Gly Leu 
65                  70                  75                  80  


Gly Phe Asn Leu Thr His Thr Pro Glu Ser Ala Ile His Gln Gly Phe 
                85                  90                  95      


Gln His Leu Val His Ser Leu Thr Val Pro Ser Lys Asp Leu Thr Leu 
            100                 105                 110         


Lys Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu Gln Leu Gln Ala 
        115                 120                 125             


Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala Glu Val Phe Ser 
    130                 135                 140                 


Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg Ile Asn Ser His 
145                 150                 155                 160 


Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile Ile Gln Gly Leu 
                165                 170                 175     


Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile Phe Phe Lys Ala 
            180                 185                 190         


Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg Lys Asn Phe Pro 
        195                 200                 205             


Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro Met Met His Gln 
    210                 215                 220                 


Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu Asn Cys Phe Val 
225                 230                 235                 240 


Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe Phe Val Leu Pro 
                245                 250                 255     


Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu Ser Ala Arg Thr 
            260                 265                 270         


Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp Ile Glu Val Phe 
        275                 280                 285             


Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu Glu Thr Ile Leu 
    290                 295                 300                 


Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn Ala Asp Phe Ser 
305                 310                 315                 320 


Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys Ala Thr His Lys 
                325                 330                 335     


Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Thr Ala Ala Thr 
            340                 345                 350         


Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr 
        355                 360                 365             


Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr Asn Lys Ala Thr 
    370                 375                 380                 


Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro Thr Lys Ser 
385                 390                 395                 


<210> 23
<211> 1200
<212> DNA
<213> Homo sapiens

<400> 23
atgagatcag ctggagggag aggagagatt aaagtgagga gagagctaca accaagtaag       60

caagtgtcag ggctcaccaa ccatgcaagg acagggcagg agaagaggaa cctgcaaagg      120

ctggttttgg agaccccgag tcagaacatc ttcttctccc ctgtgagtgt ctccacttcc      180

ctggccatgc tctcccttgg ggcccactca gtcaccaaga cccagattct ccagggcctg      240

ggcttcaacc tcacacacac accagagtct gccatccacc agggcttcca gcacctggtt      300

cactcactga ctgttcccag caaagacctg accttgaaga tgggaagtgc cctcttcgtc      360

aagaaggagc tgcagctgca ggcaaatttc ttgggcaatg tcaagaggct gtatgaagca      420

gaagtctttt ctacagattt ctccaacccc tccattgccc aggcgaggat caacagccat      480

gtgaaaaaga agacccaagg gaaggttgta gacataatcc aaggccttga ccttctgacg      540

gccatggttc tggtgaacca cattttcttt aaagccaagt gggagaagcc ctttcaccct      600

gaatatacaa gaaagaactt cccattcctg gtgggcgagc aggtcactgt gcatgtcccc      660

atgatgcacc agaaagagca gttcgctttt ggggtggata cagagctgaa ctgctttgtg      720

ctgcagatgg attacaaggg agatgccgtg gccttctttg tcctccctag caagggcaag      780

atgaggcaac tggaacaggc cttgtcagcc agaacactga gaaagtggag ccactcactc      840

cagaaaaggt ggatagaggt gttcatcccc agattttcca tttctgcctc ctacaatctg      900

gaaaccatcc tcccgaagat gggcatccaa aatgtctttg acaaaaatgc tgatttttct      960

ggaattgcaa agagagactc cctgcaggtt tctaaagcaa cccacaaggc tgtgctggat     1020

gtcagtgaag agggcactga ggccacagca gctaccacca ccaagttcat agtccgatcg     1080

aaggatggcc cctcttactt cactgtctcc ttcaatagga ccttcctgat gatgattaca     1140

aataaagcca cagacggtat tctctttcta gggaaagtgg aaaatcccac taaatcctag     1200


<210> 24
<211> 335
<212> PRT
<213> Homo sapiens

<400> 24
Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys 
1               5                   10                  15      


Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu 
            20                  25                  30          


Cys Ala Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser Ala Tyr 
        35                  40                  45              


Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser 
    50                  55                  60                  


Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu 
65                  70                  75                  80  


Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Ala Arg Ile Asn Ser His 
                85                  90                  95      


Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile Ile Gln Gly Leu 
            100                 105                 110         


Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile Phe Phe Lys Ala 
        115                 120                 125             


Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg Lys Asn Phe Pro 
    130                 135                 140                 


Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro Met Met His Gln 
145                 150                 155                 160 


Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu Asn Cys Phe Val 
                165                 170                 175     


Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe Phe Val Leu Pro 
            180                 185                 190         


Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu Ser Ala Arg Thr 
        195                 200                 205             


Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp Ile Glu Val Phe 
    210                 215                 220                 


Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu Glu Thr Ile Leu 
225                 230                 235                 240 


Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn Ala Asp Phe Ser 
                245                 250                 255     


Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys Ala Thr His Lys 
            260                 265                 270         


Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala Thr Ala Ala Thr 
        275                 280                 285             


Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro Ser Tyr Phe Thr 
    290                 295                 300                 


Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr Asn Lys Ala Thr 
305                 310                 315                 320 


Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro Thr Lys Ser 
                325                 330                 335 


<210> 25
<211> 1008
<212> DNA
<213> Homo sapiens

<400> 25
atgcaaggac agggcaggag aagaggaacc tgcaaagaca tattttgttc caaaatggca       60

tcttaccttt atggagtact ctttgctgtt ggcctctgtg ctccaatcta ctgtgtgtcc      120

ccggccaatg cccccagtgc atacccccgc ccttcctcca caaagagcac ccctgcctca      180

caggtgtatt ccctcaacac cgactttgcc ttccgcctat accgcaggct ggttttggag      240

accccgagtc agaacatctt cttctcccct gcgaggatca acagccatgt gaaaaagaag      300

acccaaggga aggttgtaga cataatccaa ggccttgacc ttctgacggc catggttctg      360

gtgaaccaca ttttctttaa agccaagtgg gagaagccct ttcaccctga atatacaaga      420

aagaacttcc cattcctggt gggcgagcag gtcactgtgc atgtccccat gatgcaccag      480

aaagagcagt tcgcttttgg ggtggataca gagctgaact gctttgtgct gcagatggat      540

tacaagggag atgccgtggc cttctttgtc ctccctagca agggcaagat gaggcaactg      600

gaacaggcct tgtcagccag aacactgaga aagtggagcc actcactcca gaaaaggtgg      660

atagaggtgt tcatccccag attttccatt tctgcctcct acaatctgga aaccatcctc      720

ccgaagatgg gcatccaaaa tgtctttgac aaaaatgctg atttttctgg aattgcaaag      780

agagactccc tgcaggtttc taaagcaacc cacaaggctg tgctggatgt cagtgaagag      840

ggcactgagg ccacagcagc taccaccacc aagttcatag tccgatcgaa ggatggcccc      900

tcttacttca ctgtctcctt caataggacc ttcctgatga tgattacaaa taaagccaca      960

gacggtattc tctttctagg gaaagtggaa aatcccacta aatcctag                  1008


<210> 26
<211> 435
<212> PRT
<213> Homo sapiens

<400> 26
Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile Phe Cys 
1               5                   10                  15      


Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val Gly Leu 
            20                  25                  30          


Cys Ala Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser Ala Tyr 
        35                  40                  45              


Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val Tyr Ser 
    50                  55                  60                  


Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val Leu Glu 
65                  70                  75                  80  


Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Val Ser Val Ser Thr Ser 
                85                  90                  95      


Leu Ala Met Leu Ser Leu Gly Ala His Ser Val Thr Lys Thr Gln Ile 
            100                 105                 110         


Leu Gln Gly Leu Gly Phe Asn Leu Thr His Thr Pro Glu Ser Ala Ile 
        115                 120                 125             


His Gln Gly Phe Gln His Leu Val His Ser Leu Thr Val Pro Ser Lys 
    130                 135                 140                 


Asp Leu Thr Leu Lys Met Gly Ser Ala Leu Phe Val Lys Lys Glu Leu 
145                 150                 155                 160 


Gln Leu Gln Ala Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr Glu Ala 
                165                 170                 175     


Glu Val Phe Ser Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln Ala Arg 
            180                 185                 190         


Ile Asn Ser His Val Lys Lys Lys Thr Gln Gly Lys Val Val Asp Ile 
        195                 200                 205             


Ile Gln Gly Leu Asp Leu Leu Thr Ala Met Val Leu Val Asn His Ile 
    210                 215                 220                 


Phe Phe Lys Ala Lys Trp Glu Lys Pro Phe His Pro Glu Tyr Thr Arg 
225                 230                 235                 240 


Lys Asn Phe Pro Phe Leu Val Gly Glu Gln Val Thr Val His Val Pro 
                245                 250                 255     


Met Met His Gln Lys Glu Gln Phe Ala Phe Gly Val Asp Thr Glu Leu 
            260                 265                 270         


Asn Cys Phe Val Leu Gln Met Asp Tyr Lys Gly Asp Ala Val Ala Phe 
        275                 280                 285             


Phe Val Leu Pro Ser Lys Gly Lys Met Arg Gln Leu Glu Gln Ala Leu 
    290                 295                 300                 


Ser Ala Arg Thr Leu Arg Lys Trp Ser His Ser Leu Gln Lys Arg Trp 
305                 310                 315                 320 


Ile Glu Val Phe Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr Asn Leu 
                325                 330                 335     


Glu Thr Ile Leu Pro Lys Met Gly Ile Gln Asn Val Phe Asp Lys Asn 
            340                 345                 350         


Ala Asp Phe Ser Gly Ile Ala Lys Arg Asp Ser Leu Gln Val Ser Lys 
        355                 360                 365             


Ala Thr His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr Glu Ala 
    370                 375                 380                 


Thr Ala Ala Thr Thr Thr Lys Phe Ile Val Arg Ser Lys Asp Gly Pro 
385                 390                 395                 400 


Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr Phe Leu Met Met Ile Thr 
                405                 410                 415     


Asn Lys Ala Thr Asp Gly Ile Leu Phe Leu Gly Lys Val Glu Asn Pro 
            420                 425                 430         


Thr Lys Ser 
        435 


<210> 27
<211> 1308
<212> DNA
<213> Homo sapiens

<400> 27
atgcaaggac agggcaggag aagaggaacc tgcaaagaca tattttgttc caaaatggca       60

tcttaccttt atggagtact ctttgctgtt ggcctctgtg ctccaatcta ctgtgtgtcc      120

ccggccaatg cccccagtgc atacccccgc ccttcctcca caaagagcac ccctgcctca      180

caggtgtatt ccctcaacac cgactttgcc ttccgcctat accgcaggct ggttttggag      240

accccgagtc agaacatctt cttctcccct gtgagtgtct ccacttccct ggccatgctc      300

tcccttgggg cccactcagt caccaagacc cagattctcc agggcctggg cttcaacctc      360

acacacacac cagagtctgc catccaccag ggcttccagc acctggttca ctcactgact      420

gttcccagca aagacctgac cttgaagatg ggaagtgccc tcttcgtcaa gaaggagctg      480

cagctgcagg caaatttctt gggcaatgtc aagaggctgt atgaagcaga agtcttttct      540

acagatttct ccaacccctc cattgcccag gcgaggatca acagccatgt gaaaaagaag      600

acccaaggga aggttgtaga cataatccaa ggccttgacc ttctgacggc catggttctg      660

gtgaaccaca ttttctttaa agccaagtgg gagaagccct ttcaccctga atatacaaga      720

aagaacttcc cattcctggt gggcgagcag gtcactgtgc atgtccccat gatgcaccag      780

aaagagcagt tcgcttttgg ggtggataca gagctgaact gctttgtgct gcagatggat      840

tacaagggag atgccgtggc cttctttgtc ctccctagca agggcaagat gaggcaactg      900

gaacaggcct tgtcagccag aacactgaga aagtggagcc actcactcca gaaaaggtgg      960

atagaggtgt tcatccccag attttccatt tctgcctcct acaatctgga aaccatcctc     1020

ccgaagatgg gcatccaaaa tgtctttgac aaaaatgctg atttttctgg aattgcaaag     1080

agagactccc tgcaggtttc taaagcaacc cacaaggctg tgctggatgt cagtgaagag     1140

ggcactgagg ccacagcagc taccaccacc aagttcatag tccgatcgaa ggatggcccc     1200

tcttacttca ctgtctcctt caataggacc ttcctgatga tgattacaaa taaagccaca     1260

gacggtattc tctttctagg gaaagtggaa aatcccacta aatcctag                  1308


<210> 28
<211> 444
<212> PRT
<213> Homo sapiens

<400> 28
Met Lys Val Val Pro Ser Leu Leu Leu Ser Val Leu Leu Ala Gln Val 
1               5                   10                  15      


Trp Leu Val Pro Gly Leu Ala Pro Ser Pro Gln Ser Pro Glu Thr Pro 
            20                  25                  30          


Ala Pro Gln Asn Gln Thr Ser Arg Val Val Gln Ala Pro Lys Glu Glu 
        35                  40                  45              


Glu Glu Asp Glu Gln Glu Ala Ser Glu Glu Lys Ala Ser Glu Glu Glu 
    50                  55                  60                  


Lys Ala Trp Leu Met Ala Ser Arg Gln Gln Leu Ala Lys Glu Thr Ser 
65                  70                  75                  80  


Asn Phe Gly Phe Ser Leu Leu Arg Lys Ile Ser Met Arg His Asp Gly 
                85                  90                  95      


Asn Met Val Phe Ser Pro Phe Gly Met Ser Leu Ala Met Thr Gly Leu 
            100                 105                 110         


Met Leu Gly Ala Thr Gly Pro Thr Glu Thr Gln Ile Lys Arg Gly Leu 
        115                 120                 125             


His Leu Gln Ala Leu Lys Pro Thr Lys Pro Gly Leu Leu Pro Ser Leu 
    130                 135                 140                 


Phe Lys Gly Leu Arg Glu Thr Leu Ser Arg Asn Leu Glu Leu Gly Leu 
145                 150                 155                 160 


Thr Gln Gly Ser Phe Ala Phe Ile His Lys Asp Phe Asp Val Lys Glu 
                165                 170                 175     


Thr Phe Phe Asn Leu Ser Lys Arg Tyr Phe Asp Thr Glu Cys Val Pro 
            180                 185                 190         


Met Asn Phe Arg Asn Ala Ser Gln Ala Lys Arg Leu Met Asn His Tyr 
        195                 200                 205             


Ile Asn Lys Glu Thr Arg Gly Lys Ile Pro Lys Leu Phe Asp Glu Ile 
    210                 215                 220                 


Asn Pro Glu Thr Lys Leu Ile Leu Val Asp Tyr Ile Leu Phe Lys Gly 
225                 230                 235                 240 


Lys Trp Leu Thr Pro Phe Asp Pro Val Phe Thr Glu Val Asp Thr Phe 
                245                 250                 255     


His Leu Asp Lys Tyr Lys Thr Ile Lys Val Pro Met Met Tyr Gly Ala 
            260                 265                 270         


Gly Lys Phe Ala Ser Thr Phe Asp Lys Asn Phe Arg Cys His Val Leu 
        275                 280                 285             


Lys Leu Pro Tyr Gln Gly Asn Ala Thr Met Leu Val Val Leu Met Glu 
    290                 295                 300                 


Lys Met Gly Asp His Leu Ala Leu Glu Asp Tyr Leu Thr Thr Asp Leu 
305                 310                 315                 320 


Val Glu Thr Trp Leu Arg Asn Met Lys Thr Arg Asn Met Glu Val Phe 
                325                 330                 335     


Phe Pro Lys Phe Lys Leu Asp Gln Lys Tyr Glu Met His Glu Leu Leu 
            340                 345                 350         


Arg Gln Met Gly Ile Arg Arg Ile Phe Ser Pro Phe Ala Asp Leu Ser 
        355                 360                 365             


Glu Leu Ser Ala Thr Gly Arg Asn Leu Gln Val Ser Arg Val Leu Gln 
    370                 375                 380                 


Arg Thr Val Ile Glu Val Asp Glu Arg Gly Thr Glu Ala Val Ala Gly 
385                 390                 395                 400 


Ile Leu Ser Glu Ile Thr Ala Tyr Ser Met Pro Pro Val Ile Lys Val 
                405                 410                 415     


Asp Arg Pro Phe His Phe Met Ile Tyr Glu Glu Thr Ser Gly Met Leu 
            420                 425                 430         


Leu Phe Leu Gly Arg Val Val Asn Pro Thr Leu Leu 
        435                 440                 


<210> 29
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 29
atgaaggtgg tgccaagtct cctgctctcc gtcctcctgg cacaggtgtg gctggtaccc       60

ggcttggccc ccagtcctca gtcgccagag accccagccc ctcagaacca gaccagcagg      120

gtagtgcagg ctcccaagga ggaagaggaa gatgagcagg aggccagcga ggagaaggcc      180

agtgaggaag agaaagcctg gctgatggcc agcaggcagc agcttgccaa ggagacttca      240

aacttcggat tcagcctgct gcgaaagatc tccatgaggc acgatggcaa catggtcttc      300

tctccatttg gcatgtcctt ggccatgaca ggcttgatgc tgggggccac agggccgact      360

gaaacccaga tcaagagagg gctccacttg caggccctga agcccaccaa gcccgggctc      420

ctgccttccc tctttaaggg actcagagag accctctccc gcaacctgga actgggcctc      480

acacagggga gttttgcctt catccacaag gattttgatg tcaaagagac tttcttcaat      540

ttatccaaga ggtattttga tacagagtgc gtgcctatga attttcgcaa tgcctcacag      600

gccaaaaggc tcatgaatca ttacattaac aaagagactc gggggaaaat tcccaaactg      660

tttgatgaga ttaatcctga aaccaaatta attcttgtgg attacatctt gttcaaaggg      720

aaatggttga ccccatttga ccctgtcttc accgaagtcg acactttcca cctggacaag      780

tacaagacca ttaaggtgcc catgatgtac ggtgcaggca agtttgcctc cacctttgac      840

aagaattttc gttgtcatgt cctcaaactg ccctaccaag gaaatgccac catgctggtg      900

gtcctcatgg agaaaatggg tgaccacctc gcccttgaag actacctgac cacagacttg      960

gtggagacat ggctcagaaa catgaaaacc agaaacatgg aagttttctt tccgaagttc     1020

aagctagatc agaagtatga gatgcatgag ctgcttaggc agatgggaat cagaagaatc     1080

ttctcaccct ttgctgacct tagtgaactc tcagctactg gaagaaatct ccaagtatcc     1140

agggttttac aaagaacagt gattgaagtt gatgaaaggg gcactgaggc agtggcagga     1200

atcttgtcag aaattactgc ttattccatg cctcctgtca tcaaagtgga ccggccattt     1260

catttcatga tctatgaaga aacctctgga atgcttctgt ttctgggcag ggtggtgaat     1320

ccgactctcc tataa                                                      1335


<210> 30
<211> 444
<212> PRT
<213> Homo sapiens

<400> 30
Met Lys Val Val Pro Ser Leu Leu Leu Ser Val Leu Leu Ala Gln Val 
1               5                   10                  15      


Trp Leu Val Pro Gly Leu Ala Pro Ser Pro Gln Ser Pro Glu Thr Pro 
            20                  25                  30          


Ala Pro Gln Asn Gln Thr Ser Arg Val Val Gln Ala Pro Lys Glu Glu 
        35                  40                  45              


Glu Glu Asp Glu Gln Glu Ala Ser Glu Glu Lys Ala Ser Glu Glu Glu 
    50                  55                  60                  


Lys Ala Trp Leu Met Ala Ser Arg Gln Gln Leu Ala Lys Glu Thr Ser 
65                  70                  75                  80  


Asn Phe Gly Phe Ser Leu Leu Arg Lys Ile Ser Met Arg His Asp Gly 
                85                  90                  95      


Asn Met Val Phe Ser Pro Phe Gly Met Ser Leu Ala Met Thr Gly Leu 
            100                 105                 110         


Met Leu Gly Ala Thr Gly Pro Thr Glu Thr Gln Ile Lys Arg Gly Leu 
        115                 120                 125             


His Leu Gln Ala Leu Lys Pro Thr Lys Pro Gly Leu Leu Pro Ser Leu 
    130                 135                 140                 


Phe Lys Gly Leu Arg Glu Thr Leu Ser Arg Asn Leu Glu Leu Gly Leu 
145                 150                 155                 160 


Thr Gln Gly Ser Phe Ala Phe Ile His Lys Asp Phe Asp Val Lys Glu 
                165                 170                 175     


Thr Phe Phe Asn Leu Ser Lys Arg Tyr Phe Asp Thr Glu Cys Val Pro 
            180                 185                 190         


Met Asn Phe Arg Asn Ala Ser Gln Ala Lys Arg Leu Met Asn His Tyr 
        195                 200                 205             


Ile Asn Lys Glu Thr Arg Gly Lys Ile Pro Lys Leu Phe Asp Glu Ile 
    210                 215                 220                 


Asn Pro Glu Thr Lys Leu Ile Leu Val Asp Tyr Ile Leu Phe Lys Gly 
225                 230                 235                 240 


Lys Trp Leu Thr Pro Phe Asp Pro Val Phe Thr Glu Val Asp Thr Phe 
                245                 250                 255     


His Leu Asp Lys Tyr Lys Thr Ile Lys Val Pro Met Met Tyr Gly Ala 
            260                 265                 270         


Gly Lys Phe Ala Ser Thr Phe Asp Lys Asn Phe Arg Cys His Val Leu 
        275                 280                 285             


Lys Leu Pro Tyr Gln Gly Asn Ala Thr Met Leu Val Val Leu Met Glu 
    290                 295                 300                 


Lys Met Gly Asp His Leu Ala Leu Glu Asp Tyr Leu Thr Thr Asp Leu 
305                 310                 315                 320 


Val Glu Thr Trp Leu Arg Asn Met Lys Thr Arg Asn Met Glu Val Phe 
                325                 330                 335     


Phe Pro Lys Phe Lys Leu Asp Gln Lys Tyr Glu Met His Glu Leu Leu 
            340                 345                 350         


Arg Gln Met Gly Ile Arg Arg Ile Phe Ser Pro Phe Ala Asp Leu Ser 
        355                 360                 365             


Glu Leu Ser Ala Thr Gly Arg Asn Leu Gln Val Ser Arg Val Leu Gln 
    370                 375                 380                 


Arg Thr Val Ile Glu Val Asp Glu Arg Gly Thr Glu Ala Val Ala Gly 
385                 390                 395                 400 


Ile Leu Ser Glu Ile Thr Ala Tyr Ser Met Pro Pro Val Ile Lys Val 
                405                 410                 415     


Asp Arg Pro Phe His Phe Met Ile Tyr Glu Glu Thr Ser Gly Met Leu 
            420                 425                 430         


Leu Phe Leu Gly Arg Val Val Asn Pro Thr Leu Leu 
        435                 440                 


<210> 31
<211> 1335
<212> DNA
<213> Homo sapiens

<400> 31
atgaaggtgg tgccaagtct cctgctctcc gtcctcctgg cacaggtgtg gctggtaccc       60

ggcttggccc ccagtcctca gtcgccagag accccagccc ctcagaacca gaccagcagg      120

gtagtgcagg ctcccaagga ggaagaggaa gatgagcagg aggccagcga ggagaaggcc      180

agtgaggaag agaaagcctg gctgatggcc agcaggcagc agcttgccaa ggagacttca      240

aacttcggat tcagcctgct gcgaaagatc tccatgaggc acgatggcaa catggtcttc      300

tctccatttg gcatgtcctt ggccatgaca ggcttgatgc tgggggccac agggccgact      360

gaaacccaga tcaagagagg gctccacttg caggccctga agcccaccaa gcccgggctc      420

ctgccttccc tctttaaggg actcagagag accctctccc gcaacctgga actgggcctc      480

acacagggga gttttgcctt catccacaag gattttgatg tcaaagagac tttcttcaat      540

ttatccaaga ggtattttga tacagagtgc gtgcctatga attttcgcaa tgcctcacag      600

gccaaaaggc tcatgaatca ttacattaac aaagagactc gggggaaaat tcccaaactg      660

tttgatgaga ttaatcctga aaccaaatta attcttgtgg attacatctt gttcaaaggg      720

aaatggttga ccccatttga ccctgtcttc accgaagtcg acactttcca cctggacaag      780

tacaagacca ttaaggtgcc catgatgtac ggtgcaggca agtttgcctc cacctttgac      840

aagaattttc gttgtcatgt cctcaaactg ccctaccaag gaaatgccac catgctggtg      900

gtcctcatgg agaaaatggg tgaccacctc gcccttgaag actacctgac cacagacttg      960

gtggagacat ggctcagaaa catgaaaacc agaaacatgg aagttttctt tccgaagttc     1020

aagctagatc agaagtatga gatgcatgag ctgcttaggc agatgggaat cagaagaatc     1080

ttctcaccct ttgctgacct tagtgaactc tcagctactg gaagaaatct ccaagtatcc     1140

agggttttac aaagaacagt gattgaagtt gatgaaaggg gcactgaggc agtggcagga     1200

atcttgtcag aaattactgc ttattccatg cctcctgtca tcaaagtgga ccggccattt     1260

catttcatga tctatgaaga aacctctgga atgcttctgt ttctgggcag ggtggtgaat     1320

ccgactctcc tataa                                                      1335


<210> 32
<211> 414
<212> PRT
<213> Homo sapiens

<400> 32
Met Asn Pro Thr Leu Gly Leu Ala Ile Phe Leu Ala Val Leu Leu Thr 
1               5                   10                  15      


Val Lys Gly Leu Leu Lys Pro Ser Phe Ser Pro Arg Asn Tyr Lys Ala 
            20                  25                  30          


Leu Ser Glu Val Gln Gly Trp Lys Gln Arg Met Ala Ala Lys Glu Leu 
        35                  40                  45              


Ala Arg Gln Asn Met Asp Leu Gly Phe Lys Leu Leu Lys Lys Leu Ala 
    50                  55                  60                  


Phe Tyr Asn Pro Gly Arg Asn Ile Phe Leu Ser Pro Leu Ser Ile Ser 
65                  70                  75                  80  


Thr Ala Phe Ser Met Leu Cys Leu Gly Ala Gln Asp Ser Thr Leu Asp 
                85                  90                  95      


Glu Ile Lys Gln Gly Phe Asn Phe Arg Lys Met Pro Glu Lys Asp Leu 
            100                 105                 110         


His Glu Gly Phe His Tyr Ile Ile His Glu Leu Thr Gln Lys Thr Gln 
        115                 120                 125             


Asp Leu Lys Leu Ser Ile Gly Asn Thr Leu Phe Ile Asp Gln Arg Leu 
    130                 135                 140                 


Gln Pro Gln Arg Lys Phe Leu Glu Asp Ala Lys Asn Phe Tyr Ser Ala 
145                 150                 155                 160 


Glu Thr Ile Leu Thr Asn Phe Gln Asn Leu Glu Met Ala Gln Lys Gln 
                165                 170                 175     


Ile Asn Asp Phe Ile Ser Gln Lys Thr His Gly Lys Ile Asn Asn Leu 
            180                 185                 190         


Ile Glu Asn Ile Asp Pro Gly Thr Val Met Leu Leu Ala Asn Tyr Ile 
        195                 200                 205             


Phe Phe Arg Ala Arg Trp Lys His Glu Phe Asp Pro Asn Val Thr Lys 
    210                 215                 220                 


Glu Glu Asp Phe Phe Leu Glu Lys Asn Ser Ser Val Lys Val Pro Met 
225                 230                 235                 240 


Met Phe Arg Ser Gly Ile Tyr Gln Val Gly Tyr Asp Asp Lys Leu Ser 
                245                 250                 255     


Cys Thr Ile Leu Glu Ile Pro Tyr Gln Lys Asn Ile Thr Ala Ile Phe 
            260                 265                 270         


Ile Leu Pro Asp Glu Gly Lys Leu Lys His Leu Glu Lys Gly Leu Gln 
        275                 280                 285             


Val Asp Thr Phe Ser Arg Trp Lys Thr Leu Leu Ser Arg Arg Val Val 
    290                 295                 300                 


Asp Val Ser Val Pro Arg Leu His Met Thr Gly Thr Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Thr Leu Ser Tyr Ile Gly Val Ser Lys Ile Phe Glu Glu His Gly 
                325                 330                 335     


Asp Leu Thr Lys Ile Ala Pro His Arg Ser Leu Lys Val Gly Glu Ala 
            340                 345                 350         


Val His Lys Ala Glu Leu Lys Met Asp Glu Arg Gly Thr Glu Gly Ala 
        355                 360                 365             


Ala Gly Thr Gly Ala Gln Thr Leu Pro Met Glu Thr Pro Leu Val Val 
    370                 375                 380                 


Lys Ile Asp Lys Pro Tyr Leu Leu Leu Ile Tyr Ser Glu Lys Ile Pro 
385                 390                 395                 400 


Ser Val Leu Phe Leu Gly Lys Ile Val Asn Pro Ile Gly Lys 
                405                 410                 


<210> 33
<211> 1245
<212> DNA
<213> Homo sapiens

<400> 33
atgaacccca cactaggcct ggccattttt ctggctgttc tcctcacggt gaaaggtctt       60

ctaaagccga gcttctcacc aaggaattat aaagctttga gcgaggtcca aggatggaag      120

caaaggatgg cagccaagga gcttgcaagg cagaacatgg acttaggctt taagctgctc      180

aagaagctgg ccttttacaa ccctggcagg aacatcttcc tatccccctt gagcatctct      240

acagctttct ccatgctgtg cctgggtgcc caggacagca ccctggacga gatcaagcag      300

gggttcaact tcagaaagat gccagaaaaa gatcttcatg agggcttcca ttacatcatc      360

cacgagctga cccagaagac ccaggacctc aaactgagca ttgggaacac gctgttcatt      420

gaccagaggc tgcagccaca gcgtaagttt ttggaagatg ccaagaactt ttacagtgcc      480

gaaaccatcc ttaccaactt tcagaatttg gaaatggctc agaagcagat caatgacttt      540

atcagtcaaa aaacccatgg gaaaattaac aacctgatcg agaatataga ccccggcact      600

gtgatgcttc ttgcaaatta tattttcttt cgagccaggt ggaaacatga gtttgatcca      660

aatgtaacta aagaggaaga tttctttctg gagaaaaaca gttcagtcaa ggtgcccatg      720

atgttccgta gtggcatata ccaagttggc tatgacgata agctctcttg caccatcctg      780

gaaataccct accagaaaaa tatcacagcc atcttcatcc ttcctgatga gggcaagctg      840

aagcacttgg agaagggatt gcaggtggac actttctcca gatggaaaac attactgtca      900

cgcagggtcg tagacgtgtc tgtacccaga ctccacatga cgggcacctt cgacctgaag      960

aagactctct cctacatagg tgtctccaaa atctttgagg aacatggtga tctcaccaag     1020

atcgcccctc atcgcagcct gaaagtgggc gaggctgtgc acaaggctga gctgaagatg     1080

gatgagaggg gtacggaagg ggccgctggc accggagcac agactctgcc catggagaca     1140

ccactcgtcg tcaagataga caaaccctat ctgctgctga tttacagcga gaaaatacct     1200

tccgtgctct tcctgggaaa gattgttaac cctattggaa aataa                     1245


<210> 34
<211> 414
<212> PRT
<213> Homo sapiens

<400> 34
Met Asn Pro Thr Leu Gly Leu Ala Ile Phe Leu Ala Val Leu Leu Thr 
1               5                   10                  15      


Val Lys Gly Leu Leu Lys Pro Ser Phe Ser Pro Arg Asn Tyr Lys Ala 
            20                  25                  30          


Leu Ser Glu Val Gln Gly Trp Lys Gln Arg Met Ala Ala Lys Glu Leu 
        35                  40                  45              


Ala Arg Gln Asn Met Asp Leu Gly Phe Lys Leu Leu Lys Lys Leu Ala 
    50                  55                  60                  


Phe Tyr Asn Pro Gly Arg Asn Ile Phe Leu Ser Pro Leu Ser Ile Ser 
65                  70                  75                  80  


Thr Ala Phe Ser Met Leu Cys Leu Gly Ala Gln Asp Ser Thr Leu Asp 
                85                  90                  95      


Glu Ile Lys Gln Gly Phe Asn Phe Arg Lys Met Pro Glu Lys Asp Leu 
            100                 105                 110         


His Glu Gly Phe His Tyr Ile Ile His Glu Leu Thr Gln Lys Thr Gln 
        115                 120                 125             


Asp Leu Lys Leu Ser Ile Gly Asn Thr Leu Phe Ile Asp Gln Arg Leu 
    130                 135                 140                 


Gln Pro Gln Arg Lys Phe Leu Glu Asp Ala Lys Asn Phe Tyr Ser Ala 
145                 150                 155                 160 


Glu Thr Ile Leu Thr Asn Phe Gln Asn Leu Glu Met Ala Gln Lys Gln 
                165                 170                 175     


Ile Asn Asp Phe Ile Ser Gln Lys Thr His Gly Lys Ile Asn Asn Leu 
            180                 185                 190         


Ile Glu Asn Ile Asp Pro Gly Thr Val Met Leu Leu Ala Asn Tyr Ile 
        195                 200                 205             


Phe Phe Arg Ala Arg Trp Lys His Glu Phe Asp Pro Asn Val Thr Lys 
    210                 215                 220                 


Glu Glu Asp Phe Phe Leu Glu Lys Asn Ser Ser Val Lys Val Pro Met 
225                 230                 235                 240 


Met Phe Arg Ser Gly Ile Tyr Gln Val Gly Tyr Asp Asp Lys Leu Ser 
                245                 250                 255     


Cys Thr Ile Leu Glu Ile Pro Tyr Gln Lys Asn Ile Thr Ala Ile Phe 
            260                 265                 270         


Ile Leu Pro Asp Glu Gly Lys Leu Lys His Leu Glu Lys Gly Leu Gln 
        275                 280                 285             


Val Asp Thr Phe Ser Arg Trp Lys Thr Leu Leu Ser Arg Arg Val Val 
    290                 295                 300                 


Asp Val Ser Val Pro Arg Leu His Met Thr Gly Thr Phe Asp Leu Lys 
305                 310                 315                 320 


Lys Thr Leu Ser Tyr Ile Gly Val Ser Lys Ile Phe Glu Glu His Gly 
                325                 330                 335     


Asp Leu Thr Lys Ile Ala Pro His Arg Ser Leu Lys Val Gly Glu Ala 
            340                 345                 350         


Val His Lys Ala Glu Leu Lys Met Asp Glu Arg Gly Thr Glu Gly Ala 
        355                 360                 365             


Ala Gly Thr Gly Ala Gln Thr Leu Pro Met Glu Thr Pro Leu Val Val 
    370                 375                 380                 


Lys Ile Asp Lys Pro Tyr Leu Leu Leu Ile Tyr Ser Glu Lys Ile Pro 
385                 390                 395                 400 


Ser Val Leu Phe Leu Gly Lys Ile Val Asn Pro Ile Gly Lys 
                405                 410                 


<210> 35
<211> 1245
<212> DNA
<213> Homo sapiens

<400> 35
atgaacccca cactaggcct ggccattttt ctggctgttc tcctcacggt gaaaggtctt       60

ctaaagccga gcttctcacc aaggaattat aaagctttga gcgaggtcca aggatggaag      120

caaaggatgg cagccaagga gcttgcaagg cagaacatgg acttaggctt taagctgctc      180

aagaagctgg ccttttacaa ccctggcagg aacatcttcc tatccccctt gagcatctct      240

acagctttct ccatgctgtg cctgggtgcc caggacagca ccctggacga gatcaagcag      300

gggttcaact tcagaaagat gccagaaaaa gatcttcatg agggcttcca ttacatcatc      360

cacgagctga cccagaagac ccaggacctc aaactgagca ttgggaacac gctgttcatt      420

gaccagaggc tgcagccaca gcgtaagttt ttggaagatg ccaagaactt ttacagtgcc      480

gaaaccatcc ttaccaactt tcagaatttg gaaatggctc agaagcagat caatgacttt      540

atcagtcaaa aaacccatgg gaaaattaac aacctgatcg agaatataga ccccggcact      600

gtgatgcttc ttgcaaatta tattttcttt cgagccaggt ggaaacatga gtttgatcca      660

aatgtaacta aagaggaaga tttctttctg gagaaaaaca gttcagtcaa ggtgcccatg      720

atgttccgta gtggcatata ccaagttggc tatgacgata agctctcttg caccatcctg      780

gaaataccct accagaaaaa tatcacagcc atcttcatcc ttcctgatga gggcaagctg      840

aagcacttgg agaagggatt gcaggtggac actttctcca gatggaaaac attactgtca      900

cgcagggtcg tagacgtgtc tgtacccaga ctccacatga cgggcacctt cgacctgaag      960

aagactctct cctacatagg tgtctccaaa atctttgagg aacatggtga tctcaccaag     1020

atcgcccctc atcgcagcct gaaagtgggc gaggctgtgc acaaggctga gctgaagatg     1080

gatgagaggg gtacggaagg ggccgctggc accggagcac agactctgcc catggagaca     1140

ccactcgtcg tcaagataga caaaccctat ctgctgctga tttacagcga gaaaatacct     1200

tccgtgctct tcctgggaaa gattgttaac cctattggaa aataa                     1245


<210> 36
<211> 379
<212> PRT
<213> Homo sapiens

<400> 36
Met Glu Gln Leu Ser Ser Ala Asn Thr Arg Phe Ala Leu Asp Leu Phe 
1               5                   10                  15      


Leu Ala Leu Ser Glu Asn Asn Pro Ala Gly Asn Ile Phe Ile Ser Pro 
            20                  25                  30          


Phe Ser Ile Ser Ser Ala Met Ala Met Val Phe Leu Gly Thr Arg Gly 
        35                  40                  45              


Asn Thr Ala Ala Gln Leu Ser Lys Thr Phe His Phe Asn Thr Val Glu 
    50                  55                  60                  


Glu Val His Ser Arg Phe Gln Ser Leu Asn Ala Asp Ile Asn Lys Arg 
65                  70                  75                  80  


Gly Ala Ser Tyr Ile Leu Lys Leu Ala Asn Arg Leu Tyr Gly Glu Lys 
                85                  90                  95      


Thr Tyr Asn Phe Leu Pro Glu Phe Leu Val Ser Thr Gln Lys Thr Tyr 
            100                 105                 110         


Gly Ala Asp Leu Ala Ser Val Asp Phe Gln His Ala Ser Glu Asp Ala 
        115                 120                 125             


Arg Lys Thr Ile Asn Gln Trp Val Lys Gly Gln Thr Glu Gly Lys Ile 
    130                 135                 140                 


Pro Glu Leu Leu Ala Ser Gly Met Val Asp Asn Met Thr Lys Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Asn Trp Lys Asp Lys Phe Met 
                165                 170                 175     


Lys Glu Ala Thr Thr Asn Ala Pro Phe Arg Leu Asn Lys Lys Asp Arg 
            180                 185                 190         


Lys Thr Val Lys Met Met Tyr Gln Lys Lys Lys Phe Ala Tyr Gly Tyr 
        195                 200                 205             


Ile Glu Asp Leu Lys Cys Arg Val Leu Glu Leu Pro Tyr Gln Gly Glu 
    210                 215                 220                 


Glu Leu Ser Met Val Ile Leu Leu Pro Asp Asp Ile Glu Asp Glu Ser 
225                 230                 235                 240 


Thr Gly Leu Lys Lys Ile Glu Glu Gln Leu Thr Leu Glu Lys Leu His 
                245                 250                 255     


Glu Trp Thr Lys Pro Glu Asn Leu Asp Phe Ile Glu Val Asn Val Ser 
            260                 265                 270         


Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Thr Leu Asn Ser Asp Leu 
        275                 280                 285             


Ala Arg Leu Gly Val Gln Asp Leu Phe Asn Ser Ser Lys Ala Asp Leu 
    290                 295                 300                 


Ser Gly Met Ser Gly Ala Arg Asp Ile Phe Ile Ser Lys Ile Val His 
305                 310                 315                 320 


Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala 
                325                 330                 335     


Thr Ala Gly Ile Ala Thr Phe Cys Met Leu Met Pro Glu Glu Asn Phe 
            340                 345                 350         


Thr Ala Asp His Pro Phe Leu Phe Phe Ile Arg His Asn Ser Ser Gly 
        355                 360                 365             


Ser Ile Leu Phe Leu Gly Arg Phe Ser Ser Pro 
    370                 375                 


<210> 37
<211> 1140
<212> DNA
<213> Homo sapiens

<400> 37
atggagcagc tgagctcagc aaacacccgc ttcgccttgg acctgttcct ggcgttgagt       60

gagaacaatc cggctggaaa catcttcatc tctcccttca gcatttcatc tgctatggcc      120

atggtttttc tggggaccag aggtaacacg gcagcacagc tgtccaagac tttccatttc      180

aacacggttg aagaggttca ttcaagattc cagagtctga atgctgatat caacaaacgt      240

ggagcgtctt atattctgaa acttgctaat agattatatg gagagaaaac ttacaatttc      300

cttcctgagt tcttggtttc gactcagaaa acatatggtg ctgacctggc cagtgtggat      360

tttcagcatg cctctgaaga tgcaaggaag accataaacc agtgggtcaa aggacagaca      420

gaaggaaaaa ttccggaact gttggcttcg ggcatggttg ataacatgac caaacttgtg      480

ctagtaaatg ccatctattt caagggaaac tggaaggata aattcatgaa agaagccacg      540

acgaatgcac cattcagatt gaataagaaa gacagaaaaa ctgtgaaaat gatgtatcag      600

aagaaaaaat ttgcatatgg ctacatcgag gaccttaagt gccgtgtgct ggaactgcct      660

taccaaggcg aggagctcag catggtcatc ctgctgccgg atgacattga ggacgagtcc      720

acgggcctga agaagattga ggaacagttg actttggaaa agttgcatga gtggactaaa      780

cctgagaatc tcgatttcat tgaagttaat gtcagcttgc ccaggttcaa actggaagag      840

agttacactc tcaactccga cctcgcccgc ctaggtgtgc aggatctctt taacagtagc      900

aaggctgatc tgtctggcat gtcaggagcc agagatattt ttatatcaaa aattgtccac      960

aagtcatttg tggaagtgaa tgaagaggga acagaggcgg cagctgccac agcaggcatc     1020

gcaactttct gcatgttgat gcccgaagaa aatttcactg ccgaccatcc attccttttc     1080

tttattcggc ataattcctc aggtagcatc ctattcttgg ggagattttc ttccccttag     1140


<210> 38
<211> 376
<212> PRT
<213> Homo sapiens

<400> 38
Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 39
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 39
atggatgttc tcgcagaagc aaatggcacc tttgccttaa accttttgaa aacgctgggt       60

aaagacaact cgaagaatgt gtttttctca cccatgagca tgtcctgtgc cctggccatg      120

gtctacatgg gggcaaaggg aaacaccgct gcacagatgg cccagatact ttctttcaat      180

aaaagtggcg gtggtggaga catccaccag ggcttccagt ctcttctcac cgaagtgaac      240

aagactggca cgcagtactt gcttaggatg gccaacaggc tctttgggga aaagtcttgt      300

gatttcctct catcttttag agattcctgc caaaaattct accaagcaga gatggaggag      360

cttgacttta tcagcgccgt agagaagtcc agaaaacaca taaacacctg ggtagctgaa      420

aagacagaag gtaaaattgc ggagttgctc tctccgggct cagtggatcc attgacaagg      480

ctggttctgg tgaatgctgt ctatttcaga ggaaactggg atgaacagtt tgacaaggag      540

aacaccgagg agagactgtt taaagtcagc aagaatgagg agaaacctgt gcaaatgatg      600

tttaagcaat ctacttttaa gaagacctat ataggagaaa tatttaccca aatcttggtg      660

cttccatatg ttggcaagga actgaatatg atcatcatgc ttccggacga gaccactgac      720

ttgagaacgg tggagaaaga actcacttac gagaagttcg tagaatggac gaggctggac      780

atgatggatg aagaggaggt ggaagtgtcc ctcccgcggt ttaaactaga ggaaagctac      840

gacatggaga gtgtcctgcg caacctgggc atgactgatg ccttcgagct gggcaaggca      900

gacttctctg gaatgtccca gacagacctg tctctgtcca aggtcgtgca caagtctttt      960

gtggaggtca atgaggaagg cacggaggct gcagccgcca cagctgccat catgatgatg     1020

cggtgtgcca gattcgtccc ccgcttctgc gccgaccacc ccttcctttt cttcatccag     1080

cacagcaaga ccaacgggat tctcttctgc ggccgctttt cctctccgtg a              1131


<210> 40
<211> 380
<212> PRT
<213> Homo sapiens

<400> 40
Met Ser Ala Ile Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala 
1               5                   10                  15      


Leu Asn Leu Leu Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe 
            20                  25                  30          


Phe Ser Pro Met Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly 
        35                  40                  45              


Ala Lys Gly Asn Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn 
    50                  55                  60                  


Lys Ser Gly Gly Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu 
65                  70                  75                  80  


Thr Glu Val Asn Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn 
                85                  90                  95      


Arg Leu Phe Gly Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp 
            100                 105                 110         


Ser Cys Gln Lys Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile 
        115                 120                 125             


Ser Ala Val Glu Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu 
    130                 135                 140                 


Lys Thr Glu Gly Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp 
145                 150                 155                 160 


Pro Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn 
                165                 170                 175     


Trp Asp Glu Gln Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys 
            180                 185                 190         


Val Ser Lys Asn Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser 
        195                 200                 205             


Thr Phe Lys Lys Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val 
    210                 215                 220                 


Leu Pro Tyr Val Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp 
225                 230                 235                 240 


Glu Thr Thr Asp Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys 
                245                 250                 255     


Phe Val Glu Trp Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu 
            260                 265                 270         


Val Ser Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser 
        275                 280                 285             


Val Leu Arg Asn Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala 
    290                 295                 300                 


Asp Phe Ser Gly Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val 
305                 310                 315                 320 


His Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala 
                325                 330                 335     


Ala Thr Ala Ala Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg 
            340                 345                 350         


Phe Cys Ala Asp His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr 
        355                 360                 365             


Asn Gly Ile Leu Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375                 380 


<210> 41
<211> 1143
<212> DNA
<213> Homo sapiens

<400> 41
atgtctgcca tcatggatgt tctcgcagaa gcaaatggca cctttgcctt aaaccttttg       60

aaaacgctgg gtaaagacaa ctcgaagaat gtgtttttct cacccatgag catgtcctgt      120

gccctggcca tggtctacat gggggcaaag ggaaacaccg ctgcacagat ggcccagata      180

ctttctttca ataaaagtgg cggtggtgga gacatccacc agggcttcca gtctcttctc      240

accgaagtga acaagactgg cacgcagtac ttgcttagga tggccaacag gctctttggg      300

gaaaagtctt gtgatttcct ctcatctttt agagattcct gccaaaaatt ctaccaagca      360

gagatggagg agcttgactt tatcagcgcc gtagagaagt ccagaaaaca cataaacacc      420

tgggtagctg aaaagacaga aggtaaaatt gcggagttgc tctctccggg ctcagtggat      480

ccattgacaa ggctggttct ggtgaatgct gtctatttca gaggaaactg ggatgaacag      540

tttgacaagg agaacaccga ggagagactg tttaaagtca gcaagaatga ggagaaacct      600

gtgcaaatga tgtttaagca atctactttt aagaagacct atataggaga aatatttacc      660

caaatcttgg tgcttccata tgttggcaag gaactgaata tgatcatcat gcttccggac      720

gagaccactg acttgagaac ggtggagaaa gaactcactt acgagaagtt cgtagaatgg      780

acgaggctgg acatgatgga tgaagaggag gtggaagtgt ccctcccgcg gtttaaacta      840

gaggaaagct acgacatgga gagtgtcctg cgcaacctgg gcatgactga tgccttcgag      900

ctgggcaagg cagacttctc tggaatgtcc cagacagacc tgtctctgtc caaggtcgtg      960

cacaagtctt ttgtggaggt caatgaggaa ggcacggagg ctgcagccgc cacagctgcc     1020

atcatgatga tgcggtgtgc cagattcgtc ccccgcttct gcgccgacca ccccttcctt     1080

ttcttcatcc agcacagcaa gaccaacggg attctcttct gcggccgctt ttcctctccg     1140

tga                                                                   1143


<210> 42
<211> 390
<212> PRT
<213> Homo sapiens

<400> 42
Met Gly Ala Ala Gln Ser Leu Pro Gly His Arg Ser Ala Ile Met Asp 
1               5                   10                  15      


Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu Lys Thr 
            20                  25                  30          


Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met Ser Met 
        35                  40                  45              


Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn Thr Ala 
    50                  55                  60                  


Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly Gly Gly 
65                  70                  75                  80  


Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn Lys Thr 
                85                  90                  95      


Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly Glu Lys 
            100                 105                 110         


Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys Phe Tyr 
        115                 120                 125             


Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu Lys Ser 
    130                 135                 140                 


Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly Lys Ile 
145                 150                 155                 160 


Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg Leu Val 
                165                 170                 175     


Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln Phe Asp 
            180                 185                 190         


Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn Glu Glu 
        195                 200                 205             


Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys Thr Tyr 
    210                 215                 220                 


Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val Gly Lys 
225                 230                 235                 240 


Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp Leu Arg 
                245                 250                 255     


Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp Thr Arg 
            260                 265                 270         


Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro Arg Phe 
        275                 280                 285             


Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn Leu Gly 
    290                 295                 300                 


Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly Met Ser 
305                 310                 315                 320 


Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe Val Glu 
                325                 330                 335     


Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala Ile Met 
            340                 345                 350         


Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp His Pro 
        355                 360                 365             


Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu Phe Cys 
    370                 375                 380                 


Gly Arg Phe Ser Ser Pro 
385                 390 


<210> 43
<211> 1173
<212> DNA
<213> Homo sapiens

<400> 43
atgggggcgg cgcagagcct cccgggccac aggtctgcca tcatggatgt tctcgcagaa       60

gcaaatggca cctttgcctt aaaccttttg aaaacgctgg gtaaagacaa ctcgaagaat      120

gtgtttttct cacccatgag catgtcctgt gccctggcca tggtctacat gggggcaaag      180

ggaaacaccg ctgcacagat ggcccagata ctttctttca ataaaagtgg cggtggtgga      240

gacatccacc agggcttcca gtctcttctc accgaagtga acaagactgg cacgcagtac      300

ttgcttagga tggccaacag gctctttggg gaaaagtctt gtgatttcct ctcatctttt      360

agagattcct gccaaaaatt ctaccaagca gagatggagg agcttgactt tatcagcgcc      420

gtagagaagt ccagaaaaca cataaacacc tgggtagctg aaaagacaga aggtaaaatt      480

gcggagttgc tctctccggg ctcagtggat ccattgacaa ggctggttct ggtgaatgct      540

gtctatttca gaggaaactg ggatgaacag tttgacaagg agaacaccga ggagagactg      600

tttaaagtca gcaagaatga ggagaaacct gtgcaaatga tgtttaagca atctactttt      660

aagaagacct atataggaga aatatttacc caaatcttgg tgcttccata tgttggcaag      720

gaactgaata tgatcatcat gcttccggac gagaccactg acttgagaac ggtggagaaa      780

gaactcactt acgagaagtt cgtagaatgg acgaggctgg acatgatgga tgaagaggag      840

gtggaagtgt ccctcccgcg gtttaaacta gaggaaagct acgacatgga gagtgtcctg      900

cgcaacctgg gcatgactga tgccttcgag ctgggcaagg cagacttctc tggaatgtcc      960

cagacagacc tgtctctgtc caaggtcgtg cacaagtctt ttgtggaggt caatgaggaa     1020

ggcacggagg ctgcagccgc cacagctgcc atcatgatga tgcggtgtgc cagattcgtc     1080

ccccgcttct gcgccgacca ccccttcctt ttcttcatcc agcacagcaa gaccaacggg     1140

attctcttct gcggccgctt ttcctctccg tga                                  1173


<210> 44
<211> 395
<212> PRT
<213> Homo sapiens

<400> 44
Met Ser Ser Arg Gln Arg Gly Asn Phe Asn Tyr Lys Leu Ala Phe Lys 
1               5                   10                  15      


Ser Ala Ile Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu 
            20                  25                  30          


Asn Leu Leu Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe 
        35                  40                  45              


Ser Pro Met Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala 
    50                  55                  60                  


Lys Gly Asn Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys 
65                  70                  75                  80  


Ser Gly Gly Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr 
                85                  90                  95      


Glu Val Asn Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg 
            100                 105                 110         


Leu Phe Gly Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser 
        115                 120                 125             


Cys Gln Lys Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser 
    130                 135                 140                 


Ala Val Glu Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys 
145                 150                 155                 160 


Thr Glu Gly Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro 
                165                 170                 175     


Leu Thr Arg Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp 
            180                 185                 190         


Asp Glu Gln Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val 
        195                 200                 205             


Ser Lys Asn Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr 
    210                 215                 220                 


Phe Lys Lys Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu 
225                 230                 235                 240 


Pro Tyr Val Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu 
                245                 250                 255     


Thr Thr Asp Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe 
            260                 265                 270         


Val Glu Trp Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val 
        275                 280                 285             


Ser Leu Pro Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val 
    290                 295                 300                 


Leu Arg Asn Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp 
305                 310                 315                 320 


Phe Ser Gly Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His 
                325                 330                 335     


Lys Ser Phe Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala 
            340                 345                 350         


Thr Ala Ala Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe 
        355                 360                 365             


Cys Ala Asp His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn 
    370                 375                 380                 


Gly Ile Leu Phe Cys Gly Arg Phe Ser Ser Pro 
385                 390                 395 


<210> 45
<211> 1188
<212> DNA
<213> Homo sapiens

<400> 45
atgtcttcaa ggcaaagagg aaactttaac tacaaattgg catttaagtc tgccatcatg       60

gatgttctcg cagaagcaaa tggcaccttt gccttaaacc ttttgaaaac gctgggtaaa      120

gacaactcga agaatgtgtt tttctcaccc atgagcatgt cctgtgccct ggccatggtc      180

tacatggggg caaagggaaa caccgctgca cagatggccc agatactttc tttcaataaa      240

agtggcggtg gtggagacat ccaccagggc ttccagtctc ttctcaccga agtgaacaag      300

actggcacgc agtacttgct taggatggcc aacaggctct ttggggaaaa gtcttgtgat      360

ttcctctcat cttttagaga ttcctgccaa aaattctacc aagcagagat ggaggagctt      420

gactttatca gcgccgtaga gaagtccaga aaacacataa acacctgggt agctgaaaag      480

acagaaggta aaattgcgga gttgctctct ccgggctcag tggatccatt gacaaggctg      540

gttctggtga atgctgtcta tttcagagga aactgggatg aacagtttga caaggagaac      600

accgaggaga gactgtttaa agtcagcaag aatgaggaga aacctgtgca aatgatgttt      660

aagcaatcta cttttaagaa gacctatata ggagaaatat ttacccaaat cttggtgctt      720

ccatatgttg gcaaggaact gaatatgatc atcatgcttc cggacgagac cactgacttg      780

agaacggtgg agaaagaact cacttacgag aagttcgtag aatggacgag gctggacatg      840

atggatgaag aggaggtgga agtgtccctc ccgcggttta aactagagga aagctacgac      900

atggagagtg tcctgcgcaa cctgggcatg actgatgcct tcgagctggg caaggcagac      960

ttctctggaa tgtcccagac agacctgtct ctgtccaagg tcgtgcacaa gtcttttgtg     1020

gaggtcaatg aggaaggcac ggaggctgca gccgccacag ctgccatcat gatgatgcgg     1080

tgtgccagat tcgtcccccg cttctgcgcc gaccacccct tccttttctt catccagcac     1140

agcaagacca acgggattct cttctgcggc cgcttttcct ctccgtga                  1188


<210> 46
<211> 376
<212> PRT
<213> Homo sapiens

<400> 46
Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 47
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 47
atggatgttc tcgcagaagc aaatggcacc tttgccttaa accttttgaa aacgctgggt       60

aaagacaact cgaagaatgt gtttttctca cccatgagca tgtcctgtgc cctggccatg      120

gtctacatgg gggcaaaggg aaacaccgct gcacagatgg cccagatact ttctttcaat      180

aaaagtggcg gtggtggaga catccaccag ggcttccagt ctcttctcac cgaagtgaac      240

aagactggca cgcagtactt gcttaggatg gccaacaggc tctttgggga aaagtcttgt      300

gatttcctct catcttttag agattcctgc caaaaattct accaagcaga gatggaggag      360

cttgacttta tcagcgccgt agagaagtcc agaaaacaca taaacacctg ggtagctgaa      420

aagacagaag gtaaaattgc ggagttgctc tctccgggct cagtggatcc attgacaagg      480

ctggttctgg tgaatgctgt ctatttcaga ggaaactggg atgaacagtt tgacaaggag      540

aacaccgagg agagactgtt taaagtcagc aagaatgagg agaaacctgt gcaaatgatg      600

tttaagcaat ctacttttaa gaagacctat ataggagaaa tatttaccca aatcttggtg      660

cttccatatg ttggcaagga actgaatatg atcatcatgc ttccggacga gaccactgac      720

ttgagaacgg tggagaaaga actcacttac gagaagttcg tagaatggac gaggctggac      780

atgatggatg aagaggaggt ggaagtgtcc ctcccgcggt ttaaactaga ggaaagctac      840

gacatggaga gtgtcctgcg caacctgggc atgactgatg ccttcgagct gggcaaggca      900

gacttctctg gaatgtccca gacagacctg tctctgtcca aggtcgtgca caagtctttt      960

gtggaggtca atgaggaagg cacggaggct gcagccgcca cagctgccat catgatgatg     1020

cggtgtgcca gattcgtccc ccgcttctgc gccgaccacc ccttcctttt cttcatccag     1080

cacagcaaga ccaacgggat tctcttctgc ggccgctttt cctctccgtg a              1131


<210> 48
<211> 376
<212> PRT
<213> Homo sapiens

<400> 48
Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 49
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 49
atggatgttc tcgcagaagc aaatggcacc tttgccttaa accttttgaa aacgctgggt       60

aaagacaact cgaagaatgt gtttttctca cccatgagca tgtcctgtgc cctggccatg      120

gtctacatgg gggcaaaggg aaacaccgct gcacagatgg cccagatact ttctttcaat      180

aaaagtggcg gtggtggaga catccaccag ggcttccagt ctcttctcac cgaagtgaac      240

aagactggca cgcagtactt gcttaggatg gccaacaggc tctttgggga aaagtcttgt      300

gatttcctct catcttttag agattcctgc caaaaattct accaagcaga gatggaggag      360

cttgacttta tcagcgccgt agagaagtcc agaaaacaca taaacacctg ggtagctgaa      420

aagacagaag gtaaaattgc ggagttgctc tctccgggct cagtggatcc attgacaagg      480

ctggttctgg tgaatgctgt ctatttcaga ggaaactggg atgaacagtt tgacaaggag      540

aacaccgagg agagactgtt taaagtcagc aagaatgagg agaaacctgt gcaaatgatg      600

tttaagcaat ctacttttaa gaagacctat ataggagaaa tatttaccca aatcttggtg      660

cttccatatg ttggcaagga actgaatatg atcatcatgc ttccggacga gaccactgac      720

ttgagaacgg tggagaaaga actcacttac gagaagttcg tagaatggac gaggctggac      780

atgatggatg aagaggaggt ggaagtgtcc ctcccgcggt ttaaactaga ggaaagctac      840

gacatggaga gtgtcctgcg caacctgggc atgactgatg ccttcgagct gggcaaggca      900

gacttctctg gaatgtccca gacagacctg tctctgtcca aggtcgtgca caagtctttt      960

gtggaggtca atgaggaagg cacggaggct gcagccgcca cagctgccat catgatgatg     1020

cggtgtgcca gattcgtccc ccgcttctgc gccgaccacc ccttcctttt cttcatccag     1080

cacagcaaga ccaacgggat tctcttctgc ggccgctttt cctctccgtg a              1131


<210> 50
<211> 376
<212> PRT
<213> Homo sapiens

<400> 50
Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 51
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 51
atggatgttc tcgcagaagc aaatggcacc tttgccttaa accttttgaa aacgctgggt       60

aaagacaact cgaagaatgt gtttttctca cccatgagca tgtcctgtgc cctggccatg      120

gtctacatgg gggcaaaggg aaacaccgct gcacagatgg cccagatact ttctttcaat      180

aaaagtggcg gtggtggaga catccaccag ggcttccagt ctcttctcac cgaagtgaac      240

aagactggca cgcagtactt gcttaggatg gccaacaggc tctttgggga aaagtcttgt      300

gatttcctct catcttttag agattcctgc caaaaattct accaagcaga gatggaggag      360

cttgacttta tcagcgccgt agagaagtcc agaaaacaca taaacacctg ggtagctgaa      420

aagacagaag gtaaaattgc ggagttgctc tctccgggct cagtggatcc attgacaagg      480

ctggttctgg tgaatgctgt ctatttcaga ggaaactggg atgaacagtt tgacaaggag      540

aacaccgagg agagactgtt taaagtcagc aagaatgagg agaaacctgt gcaaatgatg      600

tttaagcaat ctacttttaa gaagacctat ataggagaaa tatttaccca aatcttggtg      660

cttccatatg ttggcaagga actgaatatg atcatcatgc ttccggacga gaccactgac      720

ttgagaacgg tggagaaaga actcacttac gagaagttcg tagaatggac gaggctggac      780

atgatggatg aagaggaggt ggaagtgtcc ctcccgcggt ttaaactaga ggaaagctac      840

gacatggaga gtgtcctgcg caacctgggc atgactgatg ccttcgagct gggcaaggca      900

gacttctctg gaatgtccca gacagacctg tctctgtcca aggtcgtgca caagtctttt      960

gtggaggtca atgaggaagg cacggaggct gcagccgcca cagctgccat catgatgatg     1020

cggtgtgcca gattcgtccc ccgcttctgc gccgaccacc ccttcctttt cttcatccag     1080

cacagcaaga ccaacgggat tctcttctgc ggccgctttt cctctccgtg a              1131


<210> 52
<211> 376
<212> PRT
<213> Homo sapiens

<400> 52
Met Asp Val Leu Ala Glu Ala Asn Gly Thr Phe Ala Leu Asn Leu Leu 
1               5                   10                  15      


Lys Thr Leu Gly Lys Asp Asn Ser Lys Asn Val Phe Phe Ser Pro Met 
            20                  25                  30          


Ser Met Ser Cys Ala Leu Ala Met Val Tyr Met Gly Ala Lys Gly Asn 
        35                  40                  45              


Thr Ala Ala Gln Met Ala Gln Ile Leu Ser Phe Asn Lys Ser Gly Gly 
    50                  55                  60                  


Gly Gly Asp Ile His Gln Gly Phe Gln Ser Leu Leu Thr Glu Val Asn 
65                  70                  75                  80  


Lys Thr Gly Thr Gln Tyr Leu Leu Arg Met Ala Asn Arg Leu Phe Gly 
                85                  90                  95      


Glu Lys Ser Cys Asp Phe Leu Ser Ser Phe Arg Asp Ser Cys Gln Lys 
            100                 105                 110         


Phe Tyr Gln Ala Glu Met Glu Glu Leu Asp Phe Ile Ser Ala Val Glu 
        115                 120                 125             


Lys Ser Arg Lys His Ile Asn Thr Trp Val Ala Glu Lys Thr Glu Gly 
    130                 135                 140                 


Lys Ile Ala Glu Leu Leu Ser Pro Gly Ser Val Asp Pro Leu Thr Arg 
145                 150                 155                 160 


Leu Val Leu Val Asn Ala Val Tyr Phe Arg Gly Asn Trp Asp Glu Gln 
                165                 170                 175     


Phe Asp Lys Glu Asn Thr Glu Glu Arg Leu Phe Lys Val Ser Lys Asn 
            180                 185                 190         


Glu Glu Lys Pro Val Gln Met Met Phe Lys Gln Ser Thr Phe Lys Lys 
        195                 200                 205             


Thr Tyr Ile Gly Glu Ile Phe Thr Gln Ile Leu Val Leu Pro Tyr Val 
    210                 215                 220                 


Gly Lys Glu Leu Asn Met Ile Ile Met Leu Pro Asp Glu Thr Thr Asp 
225                 230                 235                 240 


Leu Arg Thr Val Glu Lys Glu Leu Thr Tyr Glu Lys Phe Val Glu Trp 
                245                 250                 255     


Thr Arg Leu Asp Met Met Asp Glu Glu Glu Val Glu Val Ser Leu Pro 
            260                 265                 270         


Arg Phe Lys Leu Glu Glu Ser Tyr Asp Met Glu Ser Val Leu Arg Asn 
        275                 280                 285             


Leu Gly Met Thr Asp Ala Phe Glu Leu Gly Lys Ala Asp Phe Ser Gly 
    290                 295                 300                 


Met Ser Gln Thr Asp Leu Ser Leu Ser Lys Val Val His Lys Ser Phe 
305                 310                 315                 320 


Val Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Ala Ala 
                325                 330                 335     


Ile Met Met Met Arg Cys Ala Arg Phe Val Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Gln His Ser Lys Thr Asn Gly Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 53
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 53
atggatgttc tcgcagaagc aaatggcacc tttgccttaa accttttgaa aacgctgggt       60

aaagacaact cgaagaatgt gtttttctca cccatgagca tgtcctgtgc cctggccatg      120

gtctacatgg gggcaaaggg aaacaccgct gcacagatgg cccagatact ttctttcaat      180

aaaagtggcg gtggtggaga catccaccag ggcttccagt ctcttctcac cgaagtgaac      240

aagactggca cgcagtactt gcttaggatg gccaacaggc tctttgggga aaagtcttgt      300

gatttcctct catcttttag agattcctgc caaaaattct accaagcaga gatggaggag      360

cttgacttta tcagcgccgt agagaagtcc agaaaacaca taaacacctg ggtagctgaa      420

aagacagaag gtaaaattgc ggagttgctc tctccgggct cagtggatcc attgacaagg      480

ctggttctgg tgaatgctgt ctatttcaga ggaaactggg atgaacagtt tgacaaggag      540

aacaccgagg agagactgtt taaagtcagc aagaatgagg agaaacctgt gcaaatgatg      600

tttaagcaat ctacttttaa gaagacctat ataggagaaa tatttaccca aatcttggtg      660

cttccatatg ttggcaagga actgaatatg atcatcatgc ttccggacga gaccactgac      720

ttgagaacgg tggagaaaga actcacttac gagaagttcg tagaatggac gaggctggac      780

atgatggatg aagaggaggt ggaagtgtcc ctcccgcggt ttaaactaga ggaaagctac      840

gacatggaga gtgtcctgcg caacctgggc atgactgatg ccttcgagct gggcaaggca      900

gacttctctg gaatgtccca gacagacctg tctctgtcca aggtcgtgca caagtctttt      960

gtggaggtca atgaggaagg cacggaggct gcagccgcca cagctgccat catgatgatg     1020

cggtgtgcca gattcgtccc ccgcttctgc gccgaccacc ccttcctttt cttcatccag     1080

cacagcaaga ccaacgggat tctcttctgc ggccgctttt cctctccgtg a              1131


<210> 54
<211> 376
<212> PRT
<213> Homo sapiens

<400> 54
Met Glu Thr Leu Ser Asn Ala Ser Gly Thr Phe Ala Ile Arg Leu Leu 
1               5                   10                  15      


Lys Ile Leu Cys Gln Asp Asn Pro Ser His Asn Val Phe Cys Ser Pro 
            20                  25                  30          


Val Ser Ile Ser Ser Ala Leu Ala Met Val Leu Leu Gly Ala Lys Gly 
        35                  40                  45              


Asn Thr Ala Thr Gln Met Ala Gln Ala Leu Ser Leu Asn Thr Glu Glu 
    50                  55                  60                  


Asp Ile His Arg Ala Phe Gln Ser Leu Leu Thr Glu Val Asn Lys Ala 
65                  70                  75                  80  


Gly Thr Gln Tyr Leu Leu Arg Thr Ala Asn Arg Leu Phe Gly Glu Lys 
                85                  90                  95      


Thr Cys Gln Phe Leu Ser Thr Phe Lys Glu Ser Cys Leu Gln Phe Tyr 
            100                 105                 110         


His Ala Glu Leu Lys Glu Leu Ser Phe Ile Arg Ala Ala Glu Glu Ser 
        115                 120                 125             


Arg Lys His Ile Asn Thr Trp Val Ser Lys Lys Thr Glu Gly Lys Ile 
    130                 135                 140                 


Glu Glu Leu Leu Pro Gly Ser Ser Ile Asp Ala Glu Thr Arg Leu Val 
145                 150                 155                 160 


Leu Val Asn Ala Ile Tyr Phe Lys Gly Lys Trp Asn Glu Pro Phe Asp 
                165                 170                 175     


Glu Thr Tyr Thr Arg Glu Met Pro Phe Lys Ile Asn Gln Glu Glu Gln 
            180                 185                 190         


Arg Pro Val Gln Met Met Tyr Gln Glu Ala Thr Phe Lys Leu Ala His 
        195                 200                 205             


Val Gly Glu Val Arg Ala Gln Leu Leu Glu Leu Pro Tyr Ala Arg Lys 
    210                 215                 220                 


Glu Leu Ser Leu Leu Val Leu Leu Pro Asp Asp Gly Val Glu Leu Ser 
225                 230                 235                 240 


Thr Val Glu Lys Ser Leu Thr Phe Glu Lys Leu Thr Ala Trp Thr Lys 
                245                 250                 255     


Pro Asp Cys Met Lys Ser Thr Glu Val Glu Val Leu Leu Pro Lys Phe 
            260                 265                 270         


Lys Leu Gln Glu Asp Tyr Asp Met Glu Ser Val Leu Arg His Leu Gly 
        275                 280                 285             


Ile Val Asp Ala Phe Gln Gln Gly Lys Ala Asp Leu Ser Ala Met Ser 
    290                 295                 300                 


Ala Glu Arg Asp Leu Cys Leu Ser Lys Phe Val His Lys Ser Phe Val 
305                 310                 315                 320 


Glu Val Asn Glu Glu Gly Thr Glu Ala Ala Ala Ala Ser Ser Cys Phe 
                325                 330                 335     


Val Val Ala Glu Cys Cys Met Glu Ser Gly Pro Arg Phe Cys Ala Asp 
            340                 345                 350         


His Pro Phe Leu Phe Phe Ile Arg His Asn Arg Ala Asn Ser Ile Leu 
        355                 360                 365             


Phe Cys Gly Arg Phe Ser Ser Pro 
    370                 375     


<210> 55
<211> 1131
<212> DNA
<213> Homo sapiens

<400> 55
atggaaactc tttctaatgc aagtggtact tttgccatac gccttttaaa gatactgtgt       60

caagataacc cttcgcacaa cgtgttctgt tctcctgtga gcatctcctc tgccctggcc      120

atggttctcc taggggcaaa gggaaacacc gcaacccaga tggcccaggc actgtcttta      180

aacacagagg aagacattca tcgggctttc cagtcgcttc tcactgaagt gaacaaggct      240

ggcacacagt acctgctgag aacggccaac aggctctttg gagagaaaac ttgtcagttc      300

ctctcaacgt ttaaggaatc ctgtcttcaa ttctaccatg ctgagctgaa ggagctttcc      360

tttatcagag ctgcagaaga gtccaggaaa cacatcaaca cctgggtctc aaaaaagacc      420

gaaggtaaaa ttgaagagtt gttgccgggt agctcaattg atgcagaaac caggctggtt      480

cttgtcaatg ccatctactt caaaggaaag tggaatgaac cgtttgacga aacatacaca      540

agggaaatgc cctttaaaat aaaccaggag gagcaaaggc cagtgcagat gatgtatcag      600

gaggccacgt ttaagctcgc ccacgtgggc gaggtgcgcg cgcagctgct ggagctgccc      660

tacgccagga aggagctgag cctgctggtg ctgctgcctg acgacggcgt ggagctcagc      720

acggtggaaa aaagtctcac ttttgagaaa ctcacagcct ggaccaagcc agactgtatg      780

aagagtactg aggttgaagt tctccttcca aaatttaaac tacaagagga ttatgacatg      840

gaatctgtgc ttcggcattt gggaattgtt gatgccttcc aacagggcaa ggctgacttg      900

tcggcaatgt cagcggagag agacctgtgt ctgtccaagt tcgtgcacaa gagttttgtg      960

gaggtgaatg aagaaggcac cgaggcagcg gcagcgtcga gctgctttgt agttgcagag     1020

tgctgcatgg aatctggccc caggttctgt gctgaccacc ctttcctttt cttcatcagg     1080

cacaacagag ccaacagcat tctgttctgt ggcaggttct catcgccata a              1131


<210> 56
<211> 500
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210> 57
<211> 1503
<212> DNA
<213> Homo sapiens

<400> 57
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

tga                                                                   1503


<210> 58
<211> 500
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Ser Arg Leu Thr Leu Leu Thr Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Gly Asp Arg Ala Ser Ser Asn Pro Asn Ala Thr Ser Ser Ser Ser Gln 
            20                  25                  30          


Asp Pro Glu Ser Leu Gln Asp Arg Gly Glu Gly Lys Val Ala Thr Thr 
        35                  40                  45              


Val Ile Ser Lys Met Leu Phe Val Glu Pro Ile Leu Glu Val Ser Ser 
    50                  55                  60                  


Leu Pro Thr Thr Asn Ser Thr Thr Asn Ser Ala Thr Lys Ile Thr Ala 
65                  70                  75                  80  


Asn Thr Thr Asp Glu Pro Thr Thr Gln Pro Thr Thr Glu Pro Thr Thr 
                85                  90                  95      


Gln Pro Thr Ile Gln Pro Thr Gln Pro Thr Thr Gln Leu Pro Thr Asp 
            100                 105                 110         


Ser Pro Thr Gln Pro Thr Thr Gly Ser Phe Cys Pro Gly Pro Val Thr 
        115                 120                 125             


Leu Cys Ser Asp Leu Glu Ser His Ser Thr Glu Ala Val Leu Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Phe Ser Leu Lys Leu Tyr His Ala Phe Ser Ala Met 
145                 150                 155                 160 


Lys Lys Val Glu Thr Asn Met Ala Phe Ser Pro Phe Ser Ile Ala Ser 
                165                 170                 175     


Leu Leu Thr Gln Val Leu Leu Gly Ala Gly Glu Asn Thr Lys Thr Asn 
            180                 185                 190         


Leu Glu Ser Ile Leu Ser Tyr Pro Lys Asp Phe Thr Cys Val His Gln 
        195                 200                 205             


Ala Leu Lys Gly Phe Thr Thr Lys Gly Val Thr Ser Val Ser Gln Ile 
    210                 215                 220                 


Phe His Ser Pro Asp Leu Ala Ile Arg Asp Thr Phe Val Asn Ala Ser 
225                 230                 235                 240 


Arg Thr Leu Tyr Ser Ser Ser Pro Arg Val Leu Ser Asn Asn Ser Asp 
                245                 250                 255     


Ala Asn Leu Glu Leu Ile Asn Thr Trp Val Ala Lys Asn Thr Asn Asn 
            260                 265                 270         


Lys Ile Ser Arg Leu Leu Asp Ser Leu Pro Ser Asp Thr Arg Leu Val 
        275                 280                 285             


Leu Leu Asn Ala Ile Tyr Leu Ser Ala Lys Trp Lys Thr Thr Phe Asp 
    290                 295                 300                 


Pro Lys Lys Thr Arg Met Glu Pro Phe His Phe Lys Asn Ser Val Ile 
305                 310                 315                 320 


Lys Val Pro Met Met Asn Ser Lys Lys Tyr Pro Val Ala His Phe Ile 
                325                 330                 335     


Asp Gln Thr Leu Lys Ala Lys Val Gly Gln Leu Gln Leu Ser His Asn 
            340                 345                 350         


Leu Ser Leu Val Ile Leu Val Pro Gln Asn Leu Lys His Arg Leu Glu 
        355                 360                 365             


Asp Met Glu Gln Ala Leu Ser Pro Ser Val Phe Lys Ala Ile Met Glu 
    370                 375                 380                 


Lys Leu Glu Met Ser Lys Phe Gln Pro Thr Leu Leu Thr Leu Pro Arg 
385                 390                 395                 400 


Ile Lys Val Thr Thr Ser Gln Asp Met Leu Ser Ile Met Glu Lys Leu 
                405                 410                 415     


Glu Phe Phe Asp Phe Ser Tyr Asp Leu Asn Leu Cys Gly Leu Thr Glu 
            420                 425                 430         


Asp Pro Asp Leu Gln Val Ser Ala Met Gln His Gln Thr Val Leu Glu 
        435                 440                 445             


Leu Thr Glu Thr Gly Val Glu Ala Ala Ala Ala Ser Ala Ile Ser Val 
    450                 455                 460                 


Ala Arg Thr Leu Leu Val Phe Glu Val Gln Gln Pro Phe Leu Phe Val 
465                 470                 475                 480 


Leu Trp Asp Gln Gln His Lys Phe Pro Val Phe Met Gly Arg Val Tyr 
                485                 490                 495     


Asp Pro Arg Ala 
            500 


<210> 59
<211> 1503
<212> DNA
<213> Homo sapiens

<400> 59
atggcctcca ggctgaccct gctgaccctc ctgctgctgc tgctggctgg ggatagagcc       60

tcctcaaatc caaatgctac cagctccagc tcccaggatc cagagagttt gcaagacaga      120

ggcgaaggga aggtcgcaac aacagttatc tccaagatgc tattcgttga acccatcctg      180

gaggtttcca gcttgccgac aaccaactca acaaccaatt cagccaccaa aataacagct      240

aataccactg atgaacccac cacacaaccc accacagagc ccaccaccca acccaccatc      300

caacccaccc aaccaactac ccagctccca acagattctc ctacccagcc cactactggg      360

tccttctgcc caggacctgt tactctctgc tctgacttgg agagtcattc aacagaggcc      420

gtgttggggg atgctttggt agatttctcc ctgaagctct accacgcctt ctcagcaatg      480

aagaaggtgg agaccaacat ggccttttcc ccattcagca tcgccagcct ccttacccag      540

gtcctgctcg gggctgggga gaacaccaaa acaaacctgg agagcatcct ctcttacccc      600

aaggacttca cctgtgtcca ccaggccctg aagggcttca cgaccaaagg tgtcacctca      660

gtctctcaga tcttccacag cccagacctg gccataaggg acacctttgt gaatgcctct      720

cggaccctgt acagcagcag ccccagagtc ctaagcaaca acagtgacgc caacttggag      780

ctcatcaaca cctgggtggc caagaacacc aacaacaaga tcagccggct gctagacagt      840

ctgccctccg atacccgcct tgtcctcctc aatgctatct acctgagtgc caagtggaag      900

acaacatttg atcccaagaa aaccagaatg gaaccctttc acttcaaaaa ctcagttata      960

aaagtgccca tgatgaatag caagaagtac cctgtggccc atttcattga ccaaactttg     1020

aaagccaagg tggggcagct gcagctctcc cacaatctga gtttggtgat cctggtaccc     1080

cagaacctga aacatcgtct tgaagacatg gaacaggctc tcagcccttc tgttttcaag     1140

gccatcatgg agaaactgga gatgtccaag ttccagccca ctctcctaac actaccccgc     1200

atcaaagtga cgaccagcca ggatatgctc tcaatcatgg agaaattgga attcttcgat     1260

ttttcttatg accttaacct gtgtgggctg acagaggacc cagatcttca ggtttctgcg     1320

atgcagcacc agacagtgct ggaactgaca gagactgggg tggaggcggc tgcagcctcc     1380

gccatctctg tggcccgcac cctgctggtc tttgaagtgc agcagccctt cctcttcgtg     1440

ctctgggacc agcagcacaa gttccctgtc ttcatggggc gagtatatga ccccagggcc     1500

tga                                                                   1503


<210> 60
<211> 410
<212> PRT
<213> Homo sapiens

<400> 60
Met Ala Phe Leu Gly Leu Phe Ser Leu Leu Val Leu Gln Ser Met Ala 
1               5                   10                  15      


Thr Gly Ala Thr Phe Pro Glu Glu Ala Ile Ala Asp Leu Ser Val Asn 
            20                  25                  30          


Met Tyr Asn Arg Leu Arg Ala Thr Gly Glu Asp Glu Asn Ile Leu Phe 
        35                  40                  45              


Ser Pro Leu Ser Ile Ala Leu Ala Met Gly Met Met Glu Leu Gly Ala 
    50                  55                  60                  


Gln Gly Ser Thr Gln Lys Glu Ile Arg His Ser Met Gly Tyr Asp Ser 
65                  70                  75                  80  


Leu Lys Asn Gly Glu Glu Phe Ser Phe Leu Lys Glu Phe Ser Asn Met 
                85                  90                  95      


Val Thr Ala Lys Glu Ser Gln Tyr Val Met Lys Ile Ala Asn Ser Leu 
            100                 105                 110         


Phe Val Gln Asn Gly Phe His Val Asn Glu Glu Phe Leu Gln Met Met 
        115                 120                 125             


Lys Lys Tyr Phe Asn Ala Ala Val Asn His Val Asp Phe Ser Gln Asn 
    130                 135                 140                 


Val Ala Val Ala Asn Tyr Ile Asn Lys Trp Val Glu Asn Asn Thr Asn 
145                 150                 155                 160 


Asn Leu Val Lys Asp Leu Val Ser Pro Arg Asp Phe Asp Ala Ala Thr 
                165                 170                 175     


Tyr Leu Ala Leu Ile Asn Ala Val Tyr Phe Lys Gly Asn Trp Lys Ser 
            180                 185                 190         


Gln Phe Arg Pro Glu Asn Thr Arg Thr Phe Ser Phe Thr Lys Asp Asp 
        195                 200                 205             


Glu Ser Glu Val Gln Ile Pro Met Met Tyr Gln Gln Gly Glu Phe Tyr 
    210                 215                 220                 


Tyr Gly Glu Phe Ser Asp Gly Ser Asn Glu Ala Gly Gly Ile Tyr Gln 
225                 230                 235                 240 


Val Leu Glu Ile Pro Tyr Glu Gly Asp Glu Ile Ser Met Met Leu Val 
                245                 250                 255     


Leu Ser Arg Gln Glu Val Pro Leu Ala Thr Leu Glu Pro Leu Val Lys 
            260                 265                 270         


Ala Gln Leu Val Glu Glu Trp Ala Asn Ser Val Lys Lys Gln Lys Val 
        275                 280                 285             


Glu Val Tyr Leu Pro Arg Phe Thr Val Glu Gln Glu Ile Asp Leu Lys 
    290                 295                 300                 


Asp Val Leu Lys Ala Leu Gly Ile Thr Glu Ile Phe Ile Lys Asp Ala 
305                 310                 315                 320 


Asn Leu Thr Gly Leu Ser Asp Asn Lys Glu Ile Phe Leu Ser Lys Ala 
                325                 330                 335     


Ile His Lys Ser Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala 
            340                 345                 350         


Ala Val Ser Gly Met Ile Ala Ile Ser Arg Met Ala Val Leu Tyr Pro 
        355                 360                 365             


Gln Val Ile Val Asp His Pro Phe Phe Phe Leu Ile Arg Asn Arg Arg 
    370                 375                 380                 


Thr Gly Thr Ile Leu Phe Met Gly Arg Val Met His Pro Glu Thr Met 
385                 390                 395                 400 


Asn Thr Ser Gly His Asp Phe Glu Glu Leu 
                405                 410 


<210> 61
<211> 1233
<212> DNA
<213> Homo sapiens

<400> 61
atggctttcc ttggactctt ctctttgctg gttctgcaaa gtatggctac aggggccact       60

ttccctgagg aagccattgc tgacttgtca gtgaatatgt ataatcgtct tagagccact      120

ggtgaagatg aaaatattct cttctctcca ttgagtattg ctcttgcaat gggaatgatg      180

gaacttgggg cccaaggatc tacccagaaa gaaatccgcc actcaatggg atatgacagc      240

ctaaaaaatg gtgaagaatt ttctttcttg aaggagtttt caaacatggt aactgctaaa      300

gagagccaat atgtgatgaa aattgccaat tccttgtttg tgcaaaatgg atttcatgtc      360

aatgaggagt ttttgcaaat gatgaaaaaa tattttaatg cagcagtaaa tcatgtggac      420

ttcagtcaaa atgtagccgt ggccaactac atcaataagt gggtggagaa taacacaaac      480

aatctggtga aagatttggt atccccaagg gattttgatg ctgccactta tctggccctc      540

attaatgctg tctatttcaa ggggaactgg aagtcgcagt ttaggcctga aaatactaga      600

accttttctt tcactaaaga tgatgaaagt gaagtccaaa ttccaatgat gtatcagcaa      660

ggagaatttt attatgggga atttagtgat ggctccaatg aagctggtgg tatctaccaa      720

gtcctagaaa taccatatga aggagatgaa ataagcatga tgctggtgct gtccagacag      780

gaagttcctc ttgctactct ggagccatta gtcaaagcac agctggttga agaatgggca      840

aactctgtga agaagcaaaa agtagaagta tacctgccca ggttcacagt ggaacaggaa      900

attgatttaa aagatgtttt gaaggctctt ggaataactg aaattttcat caaagatgca      960

aatttgacag gcctctctga taataaggag atttttcttt ccaaagcaat tcacaagtcc     1020

ttcctagagg ttaatgaaga aggctcagaa gctgctgctg tctcaggaat gattgcaatt     1080

agtaggatgg ctgtgctgta tcctcaagtt attgtcgacc atccattttt ctttcttatc     1140

agaaacagga gaactggtac aattctattc atgggacgag tcatgcatcc tgaaacaatg     1200

aacacaagtg gacatgattt cgaagaactt taa                                  1233


<210> 62
<211> 410
<212> PRT
<213> Homo sapiens

<400> 62
Met Ala Phe Leu Gly Leu Phe Ser Leu Leu Val Leu Gln Ser Met Ala 
1               5                   10                  15      


Thr Gly Ala Thr Phe Pro Glu Glu Ala Ile Ala Asp Leu Ser Val Asn 
            20                  25                  30          


Met Tyr Asn Arg Leu Arg Ala Thr Gly Glu Asp Glu Asn Ile Leu Phe 
        35                  40                  45              


Ser Pro Leu Ser Ile Ala Leu Ala Met Gly Met Met Glu Leu Gly Ala 
    50                  55                  60                  


Gln Gly Ser Thr Gln Lys Glu Ile Arg His Ser Met Gly Tyr Asp Ser 
65                  70                  75                  80  


Leu Lys Asn Gly Glu Glu Phe Ser Phe Leu Lys Glu Phe Ser Asn Met 
                85                  90                  95      


Val Thr Ala Lys Glu Ser Gln Tyr Val Met Lys Ile Ala Asn Ser Leu 
            100                 105                 110         


Phe Val Gln Asn Gly Phe His Val Asn Glu Glu Phe Leu Gln Met Met 
        115                 120                 125             


Lys Lys Tyr Phe Asn Ala Ala Val Asn His Val Asp Phe Ser Gln Asn 
    130                 135                 140                 


Val Ala Val Ala Asn Tyr Ile Asn Lys Trp Val Glu Asn Asn Thr Asn 
145                 150                 155                 160 


Asn Leu Val Lys Asp Leu Val Ser Pro Arg Asp Phe Asp Ala Ala Thr 
                165                 170                 175     


Tyr Leu Ala Leu Ile Asn Ala Val Tyr Phe Lys Gly Asn Trp Lys Ser 
            180                 185                 190         


Gln Phe Arg Pro Glu Asn Thr Arg Thr Phe Ser Phe Thr Lys Asp Asp 
        195                 200                 205             


Glu Ser Glu Val Gln Ile Pro Met Met Tyr Gln Gln Gly Glu Phe Tyr 
    210                 215                 220                 


Tyr Gly Glu Phe Ser Asp Gly Ser Asn Glu Ala Gly Gly Ile Tyr Gln 
225                 230                 235                 240 


Val Leu Glu Ile Pro Tyr Glu Gly Asp Glu Ile Ser Met Met Leu Val 
                245                 250                 255     


Leu Ser Arg Gln Glu Val Pro Leu Ala Thr Leu Glu Pro Leu Val Lys 
            260                 265                 270         


Ala Gln Leu Val Glu Glu Trp Ala Asn Ser Val Lys Lys Gln Lys Val 
        275                 280                 285             


Glu Val Tyr Leu Pro Arg Phe Thr Val Glu Gln Glu Ile Asp Leu Lys 
    290                 295                 300                 


Asp Val Leu Lys Ala Leu Gly Ile Thr Glu Ile Phe Ile Lys Asp Ala 
305                 310                 315                 320 


Asn Leu Thr Gly Leu Ser Asp Asn Lys Glu Ile Phe Leu Ser Lys Ala 
                325                 330                 335     


Ile His Lys Ser Phe Leu Glu Val Asn Glu Glu Gly Ser Glu Ala Ala 
            340                 345                 350         


Ala Val Ser Gly Met Ile Ala Ile Ser Arg Met Ala Val Leu Tyr Pro 
        355                 360                 365             


Gln Val Ile Val Asp His Pro Phe Phe Phe Leu Ile Arg Asn Arg Arg 
    370                 375                 380                 


Thr Gly Thr Ile Leu Phe Met Gly Arg Val Met His Pro Glu Thr Met 
385                 390                 395                 400 


Asn Thr Ser Gly His Asp Phe Glu Glu Leu 
                405                 410 


<210> 63
<211> 1233
<212> DNA
<213> Homo sapiens

<400> 63
atggctttcc ttggactctt ctctttgctg gttctgcaaa gtatggctac aggggccact       60

ttccctgagg aagccattgc tgacttgtca gtgaatatgt ataatcgtct tagagccact      120

ggtgaagatg aaaatattct cttctctcca ttgagtattg ctcttgcaat gggaatgatg      180

gaacttgggg cccaaggatc tacccagaaa gaaatccgcc actcaatggg atatgacagc      240

ctaaaaaatg gtgaagaatt ttctttcttg aaggagtttt caaacatggt aactgctaaa      300

gagagccaat atgtgatgaa aattgccaat tccttgtttg tgcaaaatgg atttcatgtc      360

aatgaggagt ttttgcaaat gatgaaaaaa tattttaatg cagcagtaaa tcatgtggac      420

ttcagtcaaa atgtagccgt ggccaactac atcaataagt gggtggagaa taacacaaac      480

aatctggtga aagatttggt atccccaagg gattttgatg ctgccactta tctggccctc      540

attaatgctg tctatttcaa ggggaactgg aagtcgcagt ttaggcctga aaatactaga      600

accttttctt tcactaaaga tgatgaaagt gaagtccaaa ttccaatgat gtatcagcaa      660

ggagaatttt attatgggga atttagtgat ggctccaatg aagctggtgg tatctaccaa      720

gtcctagaaa taccatatga aggagatgaa ataagcatga tgctggtgct gtccagacag      780

gaagttcctc ttgctactct ggagccatta gtcaaagcac agctggttga agaatgggca      840

aactctgtga agaagcaaaa agtagaagta tacctgccca ggttcacagt ggaacaggaa      900

attgatttaa aagatgtttt gaaggctctt ggaataactg aaattttcat caaagatgca      960

aatttgacag gcctctctga taataaggag atttttcttt ccaaagcaat tcacaagtcc     1020

ttcctagagg ttaatgaaga aggctcagaa gctgctgctg tctcaggaat gattgcaatt     1080

agtaggatgg ctgtgctgta tcctcaagtt attgtcgacc atccattttt ctttcttatc     1140

agaaacagga gaactggtac aattctattc atgggacgag tcatgcatcc tgaaacaatg     1200

aacacaagtg gacatgattt cgaagaactt taa                                  1233

