                         SEQUENCE LISTING

<110>  MacDonald, Glen Christopher
       Cizeau, Jeannick
 
<120>  METHODS OF TREATMENT FOR EPCAM POSITIVE BLADDER CANCER

<130>  VIVE-030/00US 323208-2004

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  2084
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VB4-845


<220>
<221>  CDS
<222>  (66)..(2084)

<400>  1
gaattcctgc aggtctatgg aacgataaat gcccatgaaa attctatttc aaggagacag       60

tcata atg aaa tac cta ttg cct acg gca gcc gct gga ttg tta tta ctc      110
      Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu         
      1               5                   10                  15          

gct gcc caa cca gcg atg gcg cac cat cat cac cat cac gat atc cag        158
Ala Ala Gln Pro Ala Met Ala His His His His His His Asp Ile Gln           
                20                  25                  30                

atg acc cag tcc ccg tcc tcc ctg agt gct tct gtt ggt gac cgt gtt        206
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val           
            35                  40                  45                    

acc atc acc tgc cgt tcc acc aaa tcc ctc ctg cac tcc aac ggt atc        254
Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile           
        50                  55                  60                        

acc tac ctt tat tgg tat caa cag aaa ccg ggt aaa gct ccg aaa ctt        302
Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu           
    65                  70                  75                            

ctg atc tac cag atg tcc aac ctg gct tcc ggt gtt ccg tct cgt ttc        350
Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe           
80                  85                  90                  95            

tcc agt tct ggt tct ggt acc gac ttc acc ctg acc atc tct tct ctg        398
Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu           
                100                 105                 110               

cag ccg gaa gac ttc gct acc tac tac tgc gct cag aac ctg gaa atc        446
Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile           
            115                 120                 125                   

ccg cgt acc ttc ggt cag ggt acc aaa gtt gaa ctt aag cgc gct acc        494
Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Ala Thr           
        130                 135                 140                       

ccg tct cac aac tcc cac cag gtt cca tcc gca ggc ggt ccg act gct        542
Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro Thr Ala           
    145                 150                 155                           

aac tct gga act agt gga tcc gaa gta cag ctg gtt cag tcc ggc ccg        590
Asn Ser Gly Thr Ser Gly Ser Glu Val Gln Leu Val Gln Ser Gly Pro           
160                 165                 170                 175           

ggt ctt gtt caa ccg ggt ggt tcc gtt cgt atc tct tgc gct gct tct        638
Gly Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser           
                180                 185                 190               

ggt tac acg ttc acc aac tac ggc atg aac tgg gtc aaa cag gct ccg        686
Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro           
            195                 200                 205                   

ggt aaa ggc ctg gaa tgg atg ggc tgg atc aac acc tac acc ggt gaa        734
Gly Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu           
        210                 215                 220                       

tcc acc tac gct gac tcc ttc aaa ggt cgc ttc act ttc tcc ctc gac        782
Ser Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp           
    225                 230                 235                           

aca agt gct agt gct gca tac ctc caa atc aac tcg ctg cgt gca gag        830
Thr Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu           
240                 245                 250                 255           

gat aca gca gtc tat tac tgc gcc cgt ttc gct atc aaa ggt gac tac        878
Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr           
                260                 265                 270               

tgg ggt caa ggc acg ctg ctg acc gtt tcc tcg gaa ttt ggt ggc gcg        926
Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Glu Phe Gly Gly Ala           
            275                 280                 285                   

ccg gag ttc ccg aaa ccg tcc acc ccg ccg ggt tct tct ggt tta gag        974
Pro Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Leu Glu           
        290                 295                 300                       

ggc ggc agc ctg gcc gcg ctg acc gcg cac cag gcc tgc cac ctg ccg       1022
Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro           
    305                 310                 315                           

ctg gag act ttc acc cgt cat cgc cag ccg cgc ggc tgg gaa caa ctg       1070
Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu           
320                 325                 330                 335           

gag cag tgc ggc tat ccg gtg cag cgg ctg gtc gcc ctc tac ctg gcg       1118
Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala           
                340                 345                 350               

gcg cga ctg tca tgg aac cag gtc gac cag gtg atc cgc aac gcc ctg       1166
Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu           
            355                 360                 365                   

gcc agc ccc ggc agc ggc ggc gac ctg ggc gaa gcg atc cgc gag cag       1214
Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln           
        370                 375                 380                       

ccg gag cag gcc cgt ctg gcc ctg acc ctg gcc gcc gcc gag agc gag       1262
Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu           
    385                 390                 395                           

cgc ttc gtc cgg cag ggc acc ggc aac gac gag gcc ggc gcg gcc agc       1310
Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser           
400                 405                 410                 415           

gcc gac gtg gtg agc ctg acc tgc ccg gtc gcc gcc ggt gaa tgc gcg       1358
Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala           
                420                 425                 430               

ggc ccg gcg gac agc ggc gac gcc ctg ctg gag cgc aac tat ccc act       1406
Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr           
            435                 440                 445                   

ggc gcg gag ttc ctc ggc gac ggt ggc gac gtc agc ttc agc acc cgc       1454
Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg           
        450                 455                 460                       

ggc acg cag aac tgg acg gtg gag cgg ctg ctc cag gcg cac cgc caa       1502
Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln           
    465                 470                 475                           

ctg gag gag cgc ggc tat gtg ttc gtc ggc tac cac ggc acc ttc ctc       1550
Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu           
480                 485                 490                 495           

gaa gcg gcg caa agc atc gtc ttc ggc ggg gtg cgc gcg cgc agc cag       1598
Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln           
                500                 505                 510               

gat ctc gac gcg atc tgg cgc ggt ttc tat atc gcc ggc gat ccg gcg       1646
Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala           
            515                 520                 525                   

ctg gcc tac ggc tac gcc cag gac cag gaa ccc gac gcg cgc ggc cgg       1694
Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg           
        530                 535                 540                       

atc cgc aac ggt gcc ctg ctg cgg gtc tat gtg ccg cgc tcc agc ctg       1742
Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu           
    545                 550                 555                           

ccg ggc ttc tac cgc acc ggc ctg acc ctg gcc gcg ccg gag gcg gcg       1790
Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala           
560                 565                 570                 575           

ggc gag gtc gaa cgg ctg atc ggc cat ccg ctg ccg ctg cgc ctg gac       1838
Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp           
                580                 585                 590               

gcc atc acc ggc ccc gag gag gaa ggc ggg cgc ctg gag acc att ctc       1886
Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu           
            595                 600                 605                   

ggc tgg ccg ctg gcc gag cgc acc gtg gtg att ccc tcg gcg atc ccc       1934
Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro           
        610                 615                 620                       

acc gac ccg cgc aac gtc ggt ggc gac ctc gac ccg tcc agc atc ccc       1982
Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro           
    625                 630                 635                           

gac aag gaa cag gcg atc agc gcc ctg ccg gac tac gcc agc cag ccc       2030
Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro           
640                 645                 650                 655           

ggc aaa ccg ccg cat cac cac cat cac cat aaa gac gaa ctg tag tga       2078
Gly Lys Pro Pro His His His His His His Lys Asp Glu Leu                   
                660                 665                                   

ctc gag                                                               2084
Leu Glu                                                                   
670                                                                       


<210>  2
<211>  669
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala His His His His His His Asp Ile Gln Met 
            20                  25                  30          


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
        35                  40                  45              


Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile Thr 
    50                  55                  60                  


Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
65                  70                  75                  80  


Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
                85                  90                  95      


Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
            100                 105                 110         


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn Leu Glu Ile Pro 
        115                 120                 125             


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys Arg Ala Thr Pro 
    130                 135                 140                 


Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro Thr Ala Asn 
145                 150                 155                 160 


Ser Gly Thr Ser Gly Ser Glu Val Gln Leu Val Gln Ser Gly Pro Gly 
                165                 170                 175     


Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys Ala Ala Ser Gly 
            180                 185                 190         


Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly 
        195                 200                 205             


Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser 
    210                 215                 220                 


Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr 
225                 230                 235                 240 


Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp 
                245                 250                 255     


Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp 
            260                 265                 270         


Gly Gln Gly Thr Leu Leu Thr Val Ser Ser Glu Phe Gly Gly Ala Pro 
        275                 280                 285             


Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly Ser Ser Gly Leu Glu Gly 
    290                 295                 300                 


Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu 
305                 310                 315                 320 


Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu 
                325                 330                 335     


Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala 
            340                 345                 350         


Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala 
        355                 360                 365             


Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro 
    370                 375                 380                 


Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg 
385                 390                 395                 400 


Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Ser Ala 
                405                 410                 415     


Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly 
            420                 425                 430         


Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly 
        435                 440                 445             


Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly 
    450                 455                 460                 


Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu 
465                 470                 475                 480 


Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu 
                485                 490                 495     


Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp 
            500                 505                 510         


Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu 
        515                 520                 525             


Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile 
    530                 535                 540                 


Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro 
545                 550                 555                 560 


Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly 
                565                 570                 575     


Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala 
            580                 585                 590         


Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly 
        595                 600                 605             


Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr 
    610                 615                 620                 


Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile Pro Asp 
625                 630                 635                 640 


Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly 
                645                 650                 655     


Lys Pro Pro His His His His His His Lys Asp Glu Leu 
            660                 665                 


<210>  3
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ep-CAM Binding Protein

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg Ala Thr Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly 
        115                 120                 125             


Pro Thr Ala Asn Ser Gly Thr Ser Gly Ser Glu Val Gln Leu Val Gln 
    130                 135                 140                 


Ser Gly Pro Gly Leu Val Gln Pro Gly Gly Ser Val Arg Ile Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Gly Met Asn Trp Val Lys 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Leu Glu Trp Met Gly Trp Ile Asn Thr Tyr 
            180                 185                 190         


Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe Lys Gly Arg Phe Thr Phe 
        195                 200                 205             


Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr Leu Gln Ile Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Phe Ala Ile Lys 
225                 230                 235                 240 


Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu Thr Val Ser Ser 
                245                 250                 


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (L)

<400>  4

Arg Ser Thr Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (L)

<400>  5

Gln Met Ser Asn Leu Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (L)

<400>  6

Ala Gln Asn Leu Glu Ile Pro Arg Thr 
1               5                   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 (H)

<400>  7

Asn Tyr Gly Met Asn 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 (H)

<400>  8

Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 (H)

<400>  9

Phe Ala Ile Lys Gly Asp Tyr 
1               5           


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  10

Glu Phe Gly Gly Ala Pro Glu Phe Pro Lys Pro Ser Thr Pro Pro Gly 
1               5                   10                  15      


Ser Ser Gly Leu 
            20  


<210>  11
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ETA(252-608)

<400>  11

Glu Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu 
1               5                   10                  15      


Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
            20                  25                  30          


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
        35                  40                  45              


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala 
    50                  55                  60                  


Leu Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu 
65                  70                  75                  80  


Gln Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser 
                85                  90                  95      


Glu Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala 
            100                 105                 110         


Ser Ala Asp Val Val Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys 
        115                 120                 125             


Ala Gly Pro Ala Asp Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro 
    130                 135                 140                 


Thr Gly Ala Glu Phe Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr 
145                 150                 155                 160 


Arg Gly Thr Gln Asn Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg 
                165                 170                 175     


Gln Leu Glu Glu Arg Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe 
            180                 185                 190         


Leu Glu Ala Ala Gln Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser 
        195                 200                 205             


Gln Asp Leu Asp Ala Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro 
    210                 215                 220                 


Ala Leu Ala Tyr Gly Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly 
225                 230                 235                 240 


Arg Ile Arg Asn Gly Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser 
                245                 250                 255     


Leu Pro Gly Phe Tyr Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala 
            260                 265                 270         


Ala Gly Glu Val Glu Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu 
        275                 280                 285             


Asp Ala Ile Thr Gly Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile 
    290                 295                 300                 


Leu Gly Trp Pro Leu Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile 
305                 310                 315                 320 


Pro Thr Asp Pro Arg Asn Val Gly Gly Asp Leu Asp Pro Ser Ser Ile 
                325                 330                 335     


Pro Asp Lys Glu Gln Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln 
            340                 345                 350         


Pro Gly Lys Pro Pro 
        355         


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB4-845 light chain variable region

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ser Thr Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      


Leu Glu Ile Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
            100                 105                 110         


Arg 
    


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB4-845 heavy chain variable region

<400>  13

Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ala Asp Ser Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Ala Ser Ala Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Ala Ile Lys Gly Asp Tyr Trp Gly Gln Gly Thr Leu Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  14
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VB4-845 light-heavy chain linker

<400>  14

Ala Thr Pro Ser His Asn Ser His Gln Val Pro Ser Ala Gly Gly Pro 
1               5                   10                  15      


Thr Ala Asn Ser Gly Thr Ser Gly Ser 
            20                  25  


