                         SEQUENCE LISTING

<110>  Danisco US, Inc.
 
<120>  COMPOSITIONS AND METHODS COMPRISING LG12-CLADE PROTEASE VARIANTS

<130>  40942-WO-PCT

<160>  272   

<170>  PatentIn version 3.5

<210>  1
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  1

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  2
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  placeholder

<400>  2

Gln Gln Gln Gln 
1               


<210>  3
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  3

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ala Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Val Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  4
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  4

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Val Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Ser Ser Thr Ala Thr Tyr 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  5
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  5

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  6
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  6

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  7
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  7

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  8
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  8

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  9
<211>  828
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  9
acgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtatctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgaa cgcggaacta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgcca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacaactcct ggtaacaatt atgccagctt caacggtaca      660

tcgatggctg ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta aagaatacgg caacgaattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaataa                   828


<210>  10
<211>  275
<212>  PRT
<213>  Bacillus sp.

<400>  10

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  11
<211>  10
<212>  DNA
<213>  artificial sequence

<220>
<223>  placeholder

<400>  11
aaaaaaaaaa                                                              10


<210>  12
<211>  828
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  12
gcgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtagctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgaa cgcggaacta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgtca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacaactcct ggtaacaatt atgccagctt aaacggtaca      660

tcgatggctg ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta aagaatacgg caacgaattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaataa                   828


<210>  13
<211>  825
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  13
acgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtatctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgaa cgcggaacta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgtca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacataccca ggttcaacgt atgccacatt aaacggtaca      660

tcgatggcta ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta tccagcacgg caacgtattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaa                      825


<210>  14
<211>  825
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  14
gcgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtatctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgaa cgcggaacta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgcca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacataccca ggttcaacgt atgccacatt aaacggtaca      660

tcgatggcta ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta aagaatacgg caacgaattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaa                      825


<210>  15
<211>  825
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  15
gcgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtatctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgag cgtatcccta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgcca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacaactcct ggtaacaatt atgccagctt aaacggtaca      660

tcgatggctg ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta aagaatacgg caacgaattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaa                      825


<210>  16
<211>  825
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  16
acgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtatctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgaa cgcggaacta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgcca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacataccca ggttcaacgt atgccacatt aaacggtaca      660

tcgatggcta ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta aagaatacgg caacgaattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaa                      825


<210>  17
<211>  825
<212>  DNA
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  17
acgcaaacag tgccatgggg aattcctcat atcaaagccg acaaagccca tgctgctgga       60

gtgacaggtt ctggtgtaaa agttgctatc ctcgatacag gtattgacgc aaaccatgcc      120

gacttaaatg taaaaggtgg cgctagcttt gtatctgggg aaccaaatgc tcttcaagat      180

gggaatgggc atggcacgca tgtggctggg acggtagctg ctttagataa ttcgattggc      240

gttcttggcg tagcaccgag cgtatcccta tacgctgtta aagtattagg ggcgagcggt      300

tcaggttcgg tcagctcgat tgcccaagga ttggaatggg cagggaacaa tggcatgcac      360

gttgctaatt tgagtttagg aagcccttcg ccaagtgcca cacttgagca agctgttaat      420

agcgcgactt ctagaggcgt tcttgttgta gcggcagctg ggaattcagg tacatcaggc      480

aatcggaata cgatggatta tccggcccgt tatagctctg taatcgcagt cggagctgtt      540

agtagcaaca acactcgcgc cagcttttca agtgtaggca gtgaacttga agtaatggca      600

ccaggtgtaa acattttgag cacgtaccca ggttcaacgt atgccacatt aaacggtaca      660

tcgatggctg ctcctcatgt tgcaggtgca gcagccctta tcaaagcgaa gtacccatct      720

atgacaaatg tacaaatccg caatcgtcta aagaatacgg caacgaattt aggagatcct      780

ttcttctatg gaaaaggagt catcaatgtg gaaagtgcat tacaa                      825


<210>  18
<211>  275
<212>  PRT
<213>  Bacillus sp.

<400>  18

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Arg Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ala Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ser Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ala Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Ile Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Asn Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Asn Glu Leu Glu Val Met Ala Pro Gly Ala Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asp Arg Leu Arg Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Asn Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  19
<211>  275
<212>  PRT
<213>  Bacillus horikoshii

<400>  19

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Asn Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ala Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Thr Gly Ser Thr Ala Leu Gln Gln Ala Ser Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Leu Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Ile Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Asn Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Asn 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asp Arg Leu Arg Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Arg Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  20
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  placeholder

<400>  20

Gln Gln Gln Gln 
1               


<210>  21
<211>  275
<212>  PRT
<213>  Bacillus amyloliquefaciens

<400>  21

Ala Gln Ser Val Pro Tyr Gly Val Ser Gln Ile Lys Ala Pro Ala Leu 
1               5                   10                  15      


His Ser Gln Gly Tyr Thr Gly Ser Asn Val Lys Val Ala Val Ile Asp 
            20                  25                  30          


Ser Gly Ile Asp Ser Ser His Pro Asp Leu Lys Val Ala Gly Gly Ala 
        35                  40                  45              


Ser Met Val Pro Ser Glu Thr Asn Pro Phe Gln Asp Asn Asn Ser His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Ala Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Asp Gly Ser Gly Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu 
            100                 105                 110         


Trp Ala Ile Ala Asn Asn Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Pro Ser Gly Ser Ala Ala Leu Lys Ala Ala Val Asp Lys Ala Val Ala 
    130                 135                 140                 


Ser Gly Val Val Val Val Ala Ala Ala Gly Asn Glu Gly Thr Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Thr Val Gly Tyr Pro Gly Lys Tyr Pro Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Asp Val Met Ala Pro Gly Val Ser Ile Gln Ser Thr 
        195                 200                 205             


Leu Pro Gly Asn Lys Tyr Gly Ala Tyr Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His Pro Asn 
225                 230                 235                 240 


Trp Thr Asn Thr Gln Val Arg Ser Ser Leu Glu Asn Thr Thr Thr Lys 
                245                 250                 255     


Leu Gly Asp Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala 
            260                 265                 270         


Ala Ala Gln 
        275 


<210>  22
<211>  269
<212>  PRT
<213>  Bacillus lentus

<400>  22

Ala Gln Ser Val Pro Trp Gly Ile Ser Arg Val Gln Ala Pro Ala Ala 
1               5                   10                  15      


His Asn Arg Gly Leu Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Ser Thr His Pro Asp Leu Asn Ile Arg Gly Gly Ala Ser 
        35                  40                  45              


Phe Val Pro Gly Glu Pro Ser Thr Gln Asp Gly Asn Gly His Gly Thr 
    50                  55                  60                  


His Val Ala Gly Thr Ile Ala Ala Leu Asn Asn Ser Ile Gly Val Leu 
65                  70                  75                  80  


Gly Val Ala Pro Ser Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
                85                  90                  95      


Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala 
            100                 105                 110         


Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser Pro Ser 
        115                 120                 125             


Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser Arg Gly 
    130                 135                 140                 


Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Gly Ser Ile Ser 
145                 150                 155                 160 


Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
                165                 170                 175     


Asn Asn Asn Arg Ala Ser Phe Ser Gln Tyr Gly Ala Gly Leu Asp Ile 
            180                 185                 190         


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Ser Thr Tyr 
        195                 200                 205             


Ala Ser Leu Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    210                 215                 220                 


Ala Ala Leu Val Lys Gln Lys Asn Pro Ser Trp Ser Asn Val Gln Ile 
225                 230                 235                 240 


Arg Asn His Leu Lys Asn Thr Ala Thr Ser Leu Gly Ser Thr Asn Leu 
                245                 250                 255     


Tyr Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            260                 265                 


<210>  23
<211>  274
<212>  PRT
<213>  Bacillus licheniformis

<400>  23

Ala Gln Thr Val Pro Tyr Gly Ile Pro Leu Ile Lys Ala Asp Lys Val 
1               5                   10                  15      


Gln Ala Gln Gly Phe Lys Gly Ala Asn Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Gln Ala Ser His Pro Asp Leu Asn Val Val Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ala Gly Glu Ala Tyr Asn Thr Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu Asn 
                85                  90                  95      


Ser Ser Gly Ser Gly Ser Tyr Ser Gly Ile Val Ser Gly Ile Glu Trp 
            100                 105                 110         


Ala Thr Thr Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly Ala 
        115                 120                 125             


Ser Gly Ser Thr Ala Met Lys Gln Ala Val Asp Asn Ala Tyr Ala Arg 
    130                 135                 140                 


Gly Val Val Val Val Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn 
145                 150                 155                 160 


Thr Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asp Ser Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Asp Ser Asn Ser Asn Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Ala Glu Leu Glu Val Met Ala Pro Gly Ala Gly Val Tyr Ser Thr Tyr 
        195                 200                 205             


Pro Thr Asn Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Ser Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His Pro Asn Leu 
225                 230                 235                 240 


Ser Ala Ser Gln Val Arg Asn Arg Leu Ser Ser Thr Ala Thr Tyr Leu 
                245                 250                 255     


Gly Ser Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Glu Ala Ala 
            260                 265                 270         


Ala Gln 
        


<210>  24
<211>  269
<212>  PRT
<213>  Bacillus gibsonii

<400>  24

Gln Gln Thr Val Pro Trp Gly Ile Thr Arg Val Gln Ala Pro Ala Val 
1               5                   10                  15      


His Asn Arg Gly Ile Thr Gly Ser Gly Val Arg Val Ala Ile Leu Asp 
            20                  25                  30          


Ser Gly Ile Ser Ala His Ser Asp Leu Asn Ile Arg Gly Gly Ala Ser 
        35                  40                  45              


Phe Val Pro Gly Glu Pro Thr Thr Ala Asp Leu Asn Gly His Gly Thr 
    50                  55                  60                  


His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ser Ile Gly Val Ile 
65                  70                  75                  80  


Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu Gly Ala 
                85                  90                  95      


Asn Gly Ser Gly Ser Val Ser Gly Ile Ala Gln Gly Leu Glu Trp Ala 
            100                 105                 110         


Ala Thr Asn Asn Met His Ile Ala Asn Met Ser Leu Gly Ser Asp Phe 
        115                 120                 125             


Pro Ser Ser Thr Leu Glu Arg Ala Val Asn Tyr Ala Thr Ser Arg Asp 
    130                 135                 140                 


Val Leu Val Ile Ala Ala Thr Gly Asn Asn Gly Ser Gly Ser Val Gly 
145                 150                 155                 160 


Tyr Pro Ala Arg Tyr Ala Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
                165                 170                 175     


Asn Asn Arg Arg Ala Asn Phe Ser Gln Tyr Gly Thr Gly Ile Asp Ile 
            180                 185                 190         


Val Ala Pro Gly Val Asn Val Gln Ser Thr Tyr Pro Gly Asn Arg Tyr 
        195                 200                 205             


Val Ser Met Asn Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    210                 215                 220                 


Ala Ala Leu Val Lys Gln Arg Tyr Pro Ser Trp Asn Ala Thr Gln Ile 
225                 230                 235                 240 


Arg Asn His Leu Lys Asn Thr Ala Thr Asn Leu Gly Asn Ser Ser Gln 
                245                 250                 255     


Phe Gly Ser Gly Leu Val Asn Ala Glu Ala Ala Thr Arg 
            260                 265                 


<210>  25
<211>  277
<212>  PRT
<213>  Bacillus agaradhaerens

<400>  25

Gln Gln Gln Thr Pro Trp Gly Ile Thr Arg Val Gln Gly Ile Ala Ala 
1               5                   10                  15      


Gln Ser Gln Gly Tyr Thr Gly Asn Asn Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Ser Gly Ile Asp Arg Ser His Pro Asp Leu Ser Ala Asn Val Arg Gly 
        35                  40                  45              


Gly Tyr Ser Val Phe Gly Asp Ser Pro Tyr Asn Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Gly Ala Val Asn Asn Asn Ile Gly 
65                  70                  75                  80  


Val Ile Gly Val Ala Pro Gln Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Asn Asn Ser Gly Ser Gly Ser Tyr Ala Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Asn Asn Gly Met Asp Ile Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Ser Ser Ser Ile Leu Glu Gln Tyr Cys Asn Leu Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Leu Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ala Ala 
145                 150                 155                 160 


Gly Asn Thr Asn Thr Val Gly Tyr Pro Ala Arg Tyr Asn Ser Val Ile 
                165                 170                 175     


Ala Val Ala Ala Thr Asn Ser Asn Asn Val Arg Ala Asn Phe Ser Ser 
            180                 185                 190         


Thr Gly Pro Thr Val Glu Leu Ser Ala Pro Gly Val Ser Val Leu Ser 
        195                 200                 205             


Thr Thr Pro Gly Gly Asn Tyr Ala Ser Tyr Asn Gly Thr Ser Met Ala 
    210                 215                 220                 


Ser Pro His Val Ala Gly Val Ala Ala Gln Val Trp Gln Ala Arg Pro 
225                 230                 235                 240 


Asn Leu Ser Asn Ala Gln Leu Arg Gln Ile Leu Asn Ala Ser Ala Gln 
                245                 250                 255     


Asn Leu Gly Ser Ser Tyr Gln Tyr Gly Asn Gly Leu Val Arg Ser Leu 
            260                 265                 270         


Asn Ala Ile Gln Tyr 
        275         


<210>  26
<211>  276
<212>  PRT
<213>  Bacillus sp.

<400>  26

Met His Pro Asn Gln Gln Trp His Tyr Asn Met Ile Asn Ala Pro Gln 
1               5                   10                  15      


Ala Trp Gly Thr Thr Thr Gly Ser Ser Ser Val Ile Gln Ala Val Leu 
            20                  25                  30          


Asp Thr Gly Ile Asp His Asn His Gln Ser Leu Ala Asn Leu Val Asn 
        35                  40                  45              


Thr Ser Leu Gly Gln Ser Phe Val Gly Gly Ser Thr Met Asp Val Gln 
    50                  55                  60                  


Gly His Gly Thr His Val Ala Gly Thr Ile Ala Ser Tyr Gly Ser Val 
65                  70                  75                  80  


Ser Gly Val Met His Asn Ala Thr Leu Val Pro Val Lys Val Leu Asn 
                85                  90                  95      


Asp Ser Gly Ser Gly Ser Leu Phe Gly Ile Thr Gln Gly Ile Leu Tyr 
            100                 105                 110         


Ser Ala Asp Ile Gly Ala Asp Val Ile Asn Met Ser Leu Gly Gly Gly 
        115                 120                 125             


Gly Tyr Asn Gln Ser Met Ala Glu Ala Ala Gln Thr Ala Val Asn Ala 
    130                 135                 140                 


Gly Ser Ile Val Ile Ala Ala Ser Gly Asn Asp Gly Ala Gly Ser Ile 
145                 150                 155                 160 


Ser Tyr Pro Ala Ala Tyr Ser Ser Val Ile Ala Val Gly Ser Val Thr 
                165                 170                 175     


Ser Thr Gly Ala Arg Ser Asn Phe Ser Asn Tyr Gly Ser Gly Leu Glu 
            180                 185                 190         


Leu Met Ala Pro Gly Ser Asn Ile Tyr Ser Thr Val Pro Asn Asn Gly 
        195                 200                 205             


Tyr Ala Thr Phe Ser Gly Thr Ser Met Ala Ser Pro His Ala Ala Gly 
    210                 215                 220                 


Val Ala Gly Leu Met Arg Ala Val Asn Pro Asn Leu Ser Val Ser Asn 
225                 230                 235                 240 


Ala Arg Ser Ile Met Gln Asn Thr Ala Gln Tyr Ala Gly Ser Pro Thr 
                245                 250                 255     


Phe Tyr Gly Tyr Gly Ile Val Asp Ala Asn Ala Ala Val Gln Gln Ala 
            260                 265                 270         


Ser Gly Gly Ser 
        275     


<210>  27
<211>  269
<212>  PRT
<213>  Bacillus sp.

<400>  27

Ala Gln Ala Ile Pro Trp Gly Ile Ser Gln Ile Ser Ala Pro Glu Ala 
1               5                   10                  15      


Gln Ile Ala Gly Phe Thr Gly Glu Gly Val Asn Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Glu Asp His Pro Asp Leu Asn Val Gln Gly Gly Val Ser 
        35                  40                  45              


Phe Val Gln Gly Glu Pro Asp Tyr Gln Asp Gly Asn Gly His Gly Thr 
    50                  55                  60                  


His Val Ala Gly Thr Ile Ala Ala Leu Asp Asn Asp Glu Gly Val Ile 
65                  70                  75                  80  


Gly Val Ala Pro Asn Ala Asp Leu Tyr Ala Val Lys Val Leu Gly Ala 
                85                  90                  95      


Asn Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu Trp Ala 
            100                 105                 110         


Gly Glu Asn Gly Met Asp Ile Ala Asn Leu Ser Leu Gly Ser Ser Ala 
        115                 120                 125             


Pro Ser Ala Thr Leu Glu Gln Ala Val Asp Glu Ala Thr Ala Asn Gly 
    130                 135                 140                 


Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Ala Ser Ser Ile Gly 
145                 150                 155                 160 


Tyr Pro Ala Arg Tyr Asp Asn Ala Met Ala Val Gly Ala Thr Asp Gln 
                165                 170                 175     


Ser Asp Gly Leu Ala Ser Phe Ser Gln Tyr Gly Asp Gly Leu Asp Ile 
            180                 185                 190         


Val Ala Pro Gly Val Gly Ile Asp Ser Thr Tyr Pro Gly Ser Ser Tyr 
        195                 200                 205             


Asp Ser Leu Ser Gly Thr Ser Met Ala Thr Pro His Val Ala Gly Ala 
    210                 215                 220                 


Ala Ala Leu Val Lys Glu Lys Asn Pro Leu Trp Ser Asn Glu Gln Ile 
225                 230                 235                 240 


Arg Ala His Leu Asn Glu Thr Ala Thr Asp Leu Gly Asp Met Tyr Arg 
                245                 250                 255     


Phe Gly Asn Gly Leu Leu Asn Ala His Ala Ala Val Glu 
            260                 265                 


<210>  28
<211>  276
<212>  PRT
<213>  Bacillus sp.

<400>  28

Ser Gln Thr Val Pro Tyr Gly Ile Glu Asn Ile Gly Ala Val Asp Val 
1               5                   10                  15      


Gln Gln Asn Asp Gly Asn Thr Gly Asp Gly Val Ser Val Ala Val Leu 
            20                  25                  30          


Asp Thr Gly Ile Gln Pro His Glu Asp Leu Asn Val Leu Gly Gly Ala 
        35                  40                  45              


Ser Phe Ile Ser Asp Glu Pro Thr Trp Glu Asp Phe Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Asp Leu Gly Val 
65                  70                  75                  80  


Leu Gly Val Ser Pro Asp Val Asp Leu Tyr Ala Val Lys Val Leu Gly 
                85                  90                  95      


Ala Ser Gly Gly Gly Ser His Ala Ser Ile Ala Gln Gly Ile Glu Trp 
            100                 105                 110         


Ala Val Gln Asn Asp Met Asp Ile Val Asn Met Ser Leu Gly Ser Ser 
        115                 120                 125             


Thr Gly Ser Thr Thr Leu Arg Gln Ala Val Asp Tyr Ala His Gly Glu 
    130                 135                 140                 


Gly Val Thr Leu Val Ala Ala Ala Gly Asn Ser Gly Ser Phe Leu Phe 
145                 150                 155                 160 


Leu Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asp Asn Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Asp Glu Asn Asn Ser Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Asn Gln Leu Asp Val Met Ala Pro Gly Val Ala Thr His Ser Thr Tyr 
        195                 200                 205             


Leu Asp Asn Ser Tyr Ala Ser Leu Ser Gly Thr Ser Met Ala Ser Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Leu Leu Ala His Asn Pro Val Val 
225                 230                 235                 240 


Thr Asn Glu Gly Ile Arg Glu Ala Leu Asn Ser Thr Ala Ile Pro Leu 
                245                 250                 255     


Gly Ser His Phe Tyr Tyr Gly Asn Gly Val Ile Asp Val Arg Ala Ala 
            260                 265                 270         


Leu Glu Ala Gln 
        275     


<210>  29
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  29

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Asp Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Thr Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Glu Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Ser Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  30
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  30

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  31
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  31

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  32
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  32

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  33
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  33

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  34
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  34

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Leu Ile Ala Ala Ala Gly Asn His Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  35
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  35

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  36
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  36

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  37
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  37

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Leu Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Lys Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Glu Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Asn Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asn Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ala Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Arg Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Phe Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  38
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  38

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Ala Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  39
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  39

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Ala Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  40
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  40

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  41
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  41

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Thr Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  42
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  42

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  43
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  43

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  44
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade sequence motif

<400>  44

Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His Gly Thr His 
1               5                   10                  


<210>  45
<211>  275
<212>  PRT
<213>  Bacillus horikoshii

<400>  45

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ser Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Thr Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ser Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ala Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Ala 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Arg Gly 
145                 150                 155                 160 


Lys Gln Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Asn Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asp Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  46
<211>  275
<212>  PRT
<213>  Bacillus horikoshii 

<400>  46

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Val Ala Asn Gly Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Ser Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Ala 
    130                 135                 140                 


Arg Gly Val Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Arg Gly 
145                 150                 155                 160 


Lys Gln Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Asn Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  47
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  placeholder

<400>  47

Gln Gln Gln Gln 
1               


<210>  48
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  BPN' mutant

<400>  48

Ala Gln Ser Val Pro Tyr Gly Val Ser Gln Ile Lys Ala Pro Ala Leu 
1               5                   10                  15      


His Ser Gln Gly Tyr Thr Gly Ser Asn Val Lys Val Ala Val Ile Asp 
            20                  25                  30          


Ser Gly Ile Asp Ser Ser His Pro Asp Leu Lys Val Ala Gly Gly Ala 
        35                  40                  45              


Ser Met Val Pro Ser Glu Thr Asn Pro Phe Gln Asp Asn Asn Ser His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Ala Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Asp Gly Ser Gly Gln Tyr Ser Trp Ile Ile Asn Gly Ile Glu 
            100                 105                 110         


Trp Ala Ile Ala Asn Asn Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Pro Ser Gly Ser Ala Ala Leu Lys Ala Ala Val Asp Lys Ala Val Ala 
    130                 135                 140                 


Ser Gly Val Val Val Val Ala Ala Ala Gly Asn Glu Gly Thr Ser Gly 
145                 150                 155                 160 


Ser Ser Ser Thr Val Gly Tyr Pro Gly Lys Tyr Pro Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Asp Val Met Ala Pro Gly Val Ser Ile Gln Ser Thr 
        195                 200                 205             


Leu Pro Gly Asn Lys Tyr Gly Ala Leu Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Leu Ser Lys His Pro Asn 
225                 230                 235                 240 


Trp Thr Asn Thr Gln Val Arg Ser Ser Leu Glu Asn Thr Thr Thr Lys 
                245                 250                 255     


Leu Gly Asp Ser Phe Tyr Tyr Gly Lys Gly Leu Ile Asn Val Gln Ala 
            260                 265                 270         


Ala Ala Gln 
        275 


<210>  49
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  49

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  50
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  50

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  51
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  51

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  52
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  52

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Met 
        115                 120                 125             


Val Phe Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  53
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  53

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  54
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  54

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  55
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  55

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  56
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  56

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Thr Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  57
<211>  275
<212>  PRT
<213>  Bacillus sp.

<400>  57

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Val Ala Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Ser Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Ala 
    130                 135                 140                 


Arg Gly Ile Val Val Val Ala Ala Ala Gly Asn Ser Gly Ser Arg Gly 
145                 150                 155                 160 


Lys Gln Asn Thr Ile Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Asn Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Ser Asn Val Gln Ile Arg Asp Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  58
<211>  275
<212>  PRT
<213>  Bacillus sp.

<400>  58

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Gly Thr Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ala Asn Asp Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Thr Leu Gln Gln Ala Cys Asp Asn Ala Tyr Ala 
    130                 135                 140                 


Ser Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Lys Gly 
145                 150                 155                 160 


Lys Arg Asn Thr Ile Gly Tyr Pro Ala Lys Tyr Asn Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Lys Tyr Ser Ser Phe Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Ile Ala Lys Tyr Pro Asn 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Phe Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  59
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  59

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ala Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  60
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  60

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Asn Ala Glu Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  61
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  61

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ala Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  62
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  62

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  63
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  63

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu His 
        275 


<210>  64
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  64

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ala Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ser Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  65
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  65

Thr Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Ser Ile Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Pro Ser Val Ser Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Gly Ala Ser Gly Ser Gly Ser Val Ser Ser Ile Ala Gln Gly Leu Glu 
            100                 105                 110         


Trp Ala Gly Asn Asn Gly Met His Val Ala Asn Leu Ser Leu Gly Ser 
        115                 120                 125             


Pro Ser Pro Ser Ala Thr Leu Glu Gln Ala Val Asn Ser Ala Thr Ser 
    130                 135                 140                 


Arg Gly Val Leu Val Val Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Tyr Pro Gly Ser Thr Tyr Ala Thr Leu Asn Gly Thr Ser Met Ala Thr 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  66
<211>  275
<212>  PRT
<213>  Bacillus sp.

<400>  66

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ser Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ala Asn Asp Met Asp Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Ala 
    130                 135                 140                 


Ser Gly Ile Val Val Val Ala Ala Ala Gly Asn Ser Gly Ser Lys Gly 
145                 150                 155                 160 


Lys Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asp Ser Ser Asn Asn Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Ser Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ser Ser Phe Asn Gly Thr Ser Met Ala Ser 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Lys Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Ala Phe Tyr Tyr Gly His Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  67
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  67

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Arg Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  68
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  68

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Asn Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Pro Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Ser Gly Ser Glu Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Asn 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  69
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  69

Ala Gln Val Val Pro Trp Gly Ile Val His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Arg Gly Val Thr Gly Thr Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Leu Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Pro Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Thr Gly Thr Leu Ser Gly Val Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Glu Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ala Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Glu Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Phe 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Lys 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  70
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  70

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Gly Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Asn Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  71
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  71

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Thr Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Leu Asp Leu Ser Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Lys Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Asn Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Arg Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Trp Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  72
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  72

Gly Gln Thr Val Pro Trp Gly Ile Thr His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Arg Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Ala His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Pro Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Ala Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Leu Gly Ser Gly Glu Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Trp Gly Ile Val Ser Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Ser Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  73
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  73

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asp Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Phe Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  74
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  74

Gly Gln Thr Val Pro Trp Gly Ile Ile His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Arg Gly Val Thr Gly Thr Gly Val Thr Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu His Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Thr Gly Thr Leu Ser Gly Thr Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Asp Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Ser Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Ser Asn Val Gln Ile Arg Glu Arg Leu Arg Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  75
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  75

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Gln Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asp Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Phe Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  76
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  76

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Gly Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Asn Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  77
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  77

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  78
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  78

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Gly Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Asn Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  79
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  79

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Glu Asp Leu Asp Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Val Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asn Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Thr Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  80
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  80

Gly Gln Glu Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Thr Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Gly Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Asp Ser Arg Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Asn Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  81
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  81

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Arg Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  82
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  82

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Ser Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Thr His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Asp Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Pro Tyr Ala Thr Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Glu Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Ser Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  83
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  83

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Thr Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Leu Asp Leu Ser Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Trp Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  84
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  84

Ala Gln Val Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Leu Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Pro Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Ala Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Thr Gly Thr Leu Ser Gly Thr Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Glu Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Gln Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Ala Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Tyr Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Gln Lys Tyr Pro Phe 
225                 230                 235                 240 


Met Thr Asn Val Gln Val Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  85
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  85

Gly Gln Glu Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Glu 
        35                  40                  45              


Ser Phe Val Thr Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Gly Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Asp Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Asn Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  86
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  86

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Thr Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Leu Asp Leu Ser Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Glu Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Asn Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Arg Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Trp Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  87
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  87

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Gly Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu His Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Asn Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Asn Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Asn Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  88
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  88

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Thr Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  89
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  89

Gly Gln Thr Val Pro Trp Gly Ile Thr His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Thr Gly Val Ser Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Pro Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Ala Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Thr Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Glu Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Tyr Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asn Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Tyr Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Val Lys Ala Lys Tyr Pro Phe 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Arg Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Phe Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  90
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  90

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asp Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Thr Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  91
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  91

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Val Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Asp Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Glu Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Ser Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  92
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  92

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Ser Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Val Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Asp Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Pro Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Glu Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Ser Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  93
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  93

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Ala Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  94
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  94

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Gln 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Val Ala Ala Ala Gly Asn Asn Gly Ser Asn Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Thr Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  95
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  95

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Ala Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ala Val Val Ile Ala Ala Ala Gly Asn Ser Gly Thr Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  96
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  96

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asp Val Lys Gly Gly Glu 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Thr Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  97
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  97

Gly Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Thr Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Leu Asp Leu Ser Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Glu Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Asn Gly Ile Val Asn Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Arg Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Trp Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  98
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  98

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Arg Gly Val Lys Val Ala Val Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Glu Asp Leu Asp Val Lys Gly Gly Glu 
        35                  40                  45              


Ser Phe Val Gln Asn Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Thr Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Asn Val Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ala Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Thr Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ser Gly Ala Ala Ala Leu Ile Lys Asn Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Trp Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  99
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  99

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ala 
        115                 120                 125             


Met Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  100
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  100

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Glu Leu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  101
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  101

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Lys His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  102
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  102

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  103
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  103

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Asn Met Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  104
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  104

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Asn Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  105
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  105

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Pro Phe Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  106
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  106

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Pro Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  107
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  107

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  108
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  108

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Ser Asn Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Asp 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  109
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  109

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Thr Phe Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  110
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  110

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Tyr Arg Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  111
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  111

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Glu 
        115                 120                 125             


Gly Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  112
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  112

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Glu 
        115                 120                 125             


His Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  113
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  113

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Glu 
        115                 120                 125             


Ser Arg Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  114
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  114

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Glu 
        115                 120                 125             


Val Met Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  115
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  115

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Asp Ala Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  116
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  116

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ile Ala Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  117
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  117

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Val Gln Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Arg 
        275 


<210>  118
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  118

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Lys Trp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  119
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  119

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Leu Leu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  120
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  120

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Met Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  121
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  121

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Asn Val Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  122
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  122

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Pro Leu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  123
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  123

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Pro Asn Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  124
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  124

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Pro Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  125
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  125

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Gln Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  126
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  126

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Gln Trp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  127
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  127

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Arg His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  128
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  128

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Ser Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  129
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  129

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Thr His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  130
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  130

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Thr Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  131
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  131

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Val His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  132
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  132

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Lys 
        115                 120                 125             


Ile Asn Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  133
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  133

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Gly Asn Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  134
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  134

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Met Gly Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  135
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  135

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Asn His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  136
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  136

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Thr Gln Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  137
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  137

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Val Val Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  138
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  138

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Tyr Met Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  139
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  139

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gln 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  140
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  140

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gln 
        115                 120                 125             


Arg Asn Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  141
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  141

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Arg 
        115                 120                 125             


Val Glu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  142
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  142

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Glu Trp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  143
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  143

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


His Gln Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  144
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  144

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Ile Arg Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  145
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  145

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Leu Glu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  146
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  146

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Leu Met Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  147
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  147

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Asn Val Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  148
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  148

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Pro Ala Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  149
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  149

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Gln Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  150
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  150

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Val Leu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  151
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  151

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Val Gln Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  152
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  152

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Thr 
        115                 120                 125             


Lys Leu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  153
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  153

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


His Glu Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  154
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  154

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Trp 
        115                 120                 125             


His Asp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  155
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  155

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Trp 
        115                 120                 125             


Leu Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  156
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  156

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Trp 
        115                 120                 125             


Gln Phe Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  157
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  157

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Trp 
        115                 120                 125             


Tyr Asp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  158
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  158

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Tyr 
        115                 120                 125             


Gly Thr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  159
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  159

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Tyr 
        115                 120                 125             


Pro Asp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  160
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  160

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Tyr 
        115                 120                 125             


Val Met Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  161
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  161

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Thr 
        115                 120                 125             


His Asp Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  162
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  162

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Leu 
        115                 120                 125             


Met Asn Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  163
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  163

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Met 
        115                 120                 125             


Leu Gln Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  164
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  164

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  165
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  165

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Thr His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  166
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  166

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Thr His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn His Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  167
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  167

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Thr His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn His Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Leu Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  168
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  168

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Thr His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn His Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  169
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  169

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Leu Ile Ala Ala Ala Gly Asn His Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asn Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  170
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  170

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Leu Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  171
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  171

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Thr His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Leu Ile Ala Ala Ala Gly Asn His Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  172
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  172

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Tyr Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Gln Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  173
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  173

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  174
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  174

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  175
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  175

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  176
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  176

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  177
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  177

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  178
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  178

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  179
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  179

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  180
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  180

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  181
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  181

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Lys Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  182
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  182

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  183
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  183

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  184
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  184

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  185
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  185

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  186
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  186

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  187
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  187

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  188
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  188

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Lys Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  189
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  189

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  190
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  190

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  191
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  191

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Glu 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  192
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  192

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Gly Ile Ala Ala Ala Gly Asn Asn Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  193
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  193

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Ser Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  194
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  194

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Gln Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  195
<211>  272
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  195

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Gln Asp Gly Asn Gly His Gly Thr His 
    50                  55                  60                  


Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly Val Leu Gly 
65                  70                  75                  80  


Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu Ser Ala Ser 
                85                  90                  95      


Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu Trp Ser Ile 
            100                 105                 110         


Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly Ser Ser Gly 
        115                 120                 125             


Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn Arg Gly Ile 
    130                 135                 140                 


Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn Arg Asn 
145                 150                 155                 160 


Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala Val Gly Ala 
                165                 170                 175     


Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val Gly Ser Glu 
            180                 185                 190         


Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr Thr Pro Gly 
        195                 200                 205             


Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala Pro His Val 
    210                 215                 220                 


Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser Met Thr Asn 
225                 230                 235                 240 


Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn Leu Gly Asp 
                245                 250                 255     


Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser Ala Leu Gln 
            260                 265                 270         


<210>  196
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  196

Ala Gln Thr Val Pro Trp Gly Ile Thr His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Arg Gly Gly Glu 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Ala Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asn 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asp Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Val Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Asn Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Pro Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Val Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Ala Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Pro 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Gln 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  197
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  197

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu Ser 
                85                  90                  95      


Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu Trp 
            100                 105                 110         


Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly Ser 
        115                 120                 125             


Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn Arg 
    130                 135                 140                 


Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn 
145                 150                 155                 160 


Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr Thr 
        195                 200                 205             


Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser Met 
225                 230                 235                 240 


Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn Leu 
                245                 250                 255     


Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser Ala 
            260                 265                 270         


Leu Gln 
        


<210>  198
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  198

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Asn Ala Leu Gln Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu Ser 
                85                  90                  95      


Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu Trp 
            100                 105                 110         


Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly Ser 
        115                 120                 125             


Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn Arg 
    130                 135                 140                 


Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn 
145                 150                 155                 160 


Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr Thr 
        195                 200                 205             


Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser Met 
225                 230                 235                 240 


Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn Leu 
                245                 250                 255     


Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser Ala 
            260                 265                 270         


Leu Gln 
        


<210>  199
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  199

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Leu Gln Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu Ser 
                85                  90                  95      


Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu Trp 
            100                 105                 110         


Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly Ser 
        115                 120                 125             


Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn Arg 
    130                 135                 140                 


Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn 
145                 150                 155                 160 


Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr Thr 
        195                 200                 205             


Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser Met 
225                 230                 235                 240 


Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn Leu 
                245                 250                 255     


Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser Ala 
            260                 265                 270         


Leu Gln 
        


<210>  200
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  200

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Asp Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Glu Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  201
<211>  274
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  201

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Gln Asp Gly Asn Gly His Gly 
    50                  55                  60                  


Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly Val 
65                  70                  75                  80  


Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu Ser 
                85                  90                  95      


Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu Trp 
            100                 105                 110         


Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly Ser 
        115                 120                 125             


Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn Arg 
    130                 135                 140                 


Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly Asn 
145                 150                 155                 160 


Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala Val 
                165                 170                 175     


Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val Gly 
            180                 185                 190         


Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr Thr 
        195                 200                 205             


Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala Pro 
    210                 215                 220                 


His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser Met 
225                 230                 235                 240 


Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn Leu 
                245                 250                 255     


Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser Ala 
            260                 265                 270         


Leu Gln 
        


<210>  202
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  202

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Ala Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Phe Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  203
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  203

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Gln His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Ala Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Ser Arg Met Asn Val Ile Asn Met Ser Leu Gly His 
        115                 120                 125             


Ser Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  204
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  204

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Met 
        115                 120                 125             


Ser Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Lys Cys Gly Lys 
            260                 265                 270         


Val Leu Tyr 
        275 


<210>  205
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  205

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Met 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  206
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  206

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Phe Phe Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  207
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  207

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Gly 
        115                 120                 125             


Phe Ser Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  208
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  208

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Met 
        115                 120                 125             


Phe Phe Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  209
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  209

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Asp Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Gln Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Ser 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Phe Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  210
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  210

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Met Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Lys Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  211
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  211

Ala Gln Thr Val Pro Trp Cys Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  212
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  212

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Thr Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  213
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  213

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  214
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  214

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Arg Ile Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Lys Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  215
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  215

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  216
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  216

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  217
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  217

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  218
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  218

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  219
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  219

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  220
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  220

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  221
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  221

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  222
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  222

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  223
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  223

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  224
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  224

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  225
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  225

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  226
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  226

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  227
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  227

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  228
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  228

Ala Gln Thr Val Pro Trp Cys Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  229
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  229

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  230
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  230

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  231
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  231

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  232
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  232

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Asp Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  233
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  233

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Arg 
        275 


<210>  234
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  234

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  235
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  235

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  236
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  236

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  237
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  237

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  238
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  238

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  239
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  239

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  240
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  240

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  241
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  241

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  242
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  242

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  243
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  243

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  244
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  244

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Val Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  245
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  245

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Arg 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  246
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  246

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  247
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  247

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Phe Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Asp 
        115                 120                 125             


Phe Tyr Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asn Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  248
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  248

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  249
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  249

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  250
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  250

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  251
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  251

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  252
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  252

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  253
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  253

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  254
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  254

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  255
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  255

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  256
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  256

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  257
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  257

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  258
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  258

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  259
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  259

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  260
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  260

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  261
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  261

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met His Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  262
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  262

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  263
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  263

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  264
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  264

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  265
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  265

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  266
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  266

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asp Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  267
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  267

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  268
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  268

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Phe Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  269
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  269

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Tyr Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  270
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  270

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Glu Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  271
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  271

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Thr Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asp Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Arg Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Asp Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Asp Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Glu 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Lys 
            260                 265                 270         


Ala Leu Gln 
        275 


<210>  272
<211>  275
<212>  PRT
<213>  artificial sequence

<220>
<223>  LG12-clade protease variant

<400>  272

Ala Gln Thr Val Pro Trp Gly Ile Pro His Ile Lys Ala Asp Lys Ala 
1               5                   10                  15      


His Ala Ala Gly Val Thr Gly Ser Gly Val Lys Val Ala Ile Leu Asp 
            20                  25                  30          


Thr Gly Ile Asp Ala Asn His Ala Asp Leu Asn Val Lys Gly Gly Ala 
        35                  40                  45              


Ser Phe Val Ser Gly Glu Pro Asn Ala Leu Gln Asp Gly Asn Gly His 
    50                  55                  60                  


Gly Thr His Val Ala Gly Thr Val Ala Ala Leu Asn Asn Thr Thr Gly 
65                  70                  75                  80  


Val Leu Gly Val Ala Tyr Asn Ala Asp Leu Tyr Ala Val Lys Val Leu 
                85                  90                  95      


Ser Ala Ser Gly Ser Gly Thr Leu Ser Gly Ile Ala Gln Gly Ile Glu 
            100                 105                 110         


Trp Ser Ile Ser Asn Gly Met Asn Val Ile Asn Met Ser Leu Gly Val 
        115                 120                 125             


Met His Gly Ser Thr Ala Leu Gln Gln Ala Cys Asn Asn Ala Tyr Asn 
    130                 135                 140                 


Arg Gly Ile Val Val Ile Ala Ala Ala Gly Asn Ser Gly Ser Ser Gly 
145                 150                 155                 160 


Asn Arg Asn Thr Met Gly Tyr Pro Ala Arg Tyr Ser Ser Val Ile Ala 
                165                 170                 175     


Val Gly Ala Val Ser Ser Asn Asn Thr Arg Ala Ser Phe Ser Ser Val 
            180                 185                 190         


Gly Ser Glu Leu Glu Val Met Ala Pro Gly Val Asn Ile Leu Ser Thr 
        195                 200                 205             


Thr Pro Gly Asn Asn Tyr Ala Ser Arg Asn Gly Thr Ser Met Ala Ala 
    210                 215                 220                 


Pro His Val Ala Gly Ala Ala Ala Leu Ile Lys Ala Lys Tyr Pro Ser 
225                 230                 235                 240 


Met Thr Asn Val Gln Ile Arg Asn Arg Leu Lys Asn Thr Ala Thr Asn 
                245                 250                 255     


Leu Gly Asp Pro Phe Phe Tyr Gly Lys Gly Val Ile Asn Val Glu Ser 
            260                 265                 270         


Ala Leu Gln 
        275 


