               SEQUENCE LISTING

<110> Mediagnost Gesellschaft fr Forschung und Herstellung von Diagnostika GmbH

<120> Zusammenstellung von Nachweisreagenzien, In-vitro-Verfahren zum Nachweisen von mutiertem Leptin und Verwendung eines Nachweisreagenzes

<130> E/53284WO/AW/kn

<160> 10

<170> BiSSAP 1.0

<210> 1
<211> 167
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..167
<223> /mol_type="protein"
      /note="Leptin Precursor"
      /organism="Homo sapiens"

<400> 1
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                   15    
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                   25                  30        
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                   40                  45            
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                   55                  60                
Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                   70                  75                  80
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                   90                  95    
Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                  105                110        
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                  120                125            
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                  135                140                
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                  150                155                  160
Leu Asp Leu Ser Pro Gly Cys 
                165        

<210> 2
<211> 167
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..167
<223> /mol_type="protein"
      /note="Leptin Precursor Variante D100Y"
      /organism="Homo sapiens"

<400> 2
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                   15    
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                   25                  30        
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                   40                  45            
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                   55                  60                
Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                   70                  75                  80
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                   90                  95    
Ile Ser Asn Tyr Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                  105                110        
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                  120                125            
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                  135                140                
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                  150                155                  160
Leu Asp Leu Ser Pro Gly Cys 
                165        

<210> 3
<211> 167
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..167
<223> /mol_type="protein"
      /note="Leptin Precursor Variante N103K"
      /organism="Homo sapiens"

<400> 3
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                   15    
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                   25                  30        
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                   40                  45            
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                   55                  60                
Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                   70                  75                  80
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                   90                  95    
Ile Ser Asn Asp Leu Glu Lys Leu Arg Asp Leu Leu His Val Leu Ala 
            100                  105                110        
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                  120                125            
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                  135                140                
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                  150                155                  160
Leu Asp Leu Ser Pro Gly Cys 
                165        

<210> 4
<211> 167
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..167
<223> /mol_type="protein"
      /note="Leptin Precursor Variante L72S"
      /organism="Homo sapiens"

<400> 4
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                   15    
Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                   25                  30        
Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                   40                  45            
Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                   55                  60                
Gly Leu His Pro Ile Leu Thr Ser Ser Lys Met Asp Gln Thr Leu Ala 
65                   70                  75                  80
Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                   90                  95    
Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                  105                110        
Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                  120                125            
Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                  135                140                
Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                  150                155                  160
Leu Asp Leu Ser Pro Gly Cys 
                165        

<210> 5
<211> 896
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..896
<223> /mol_type="protein"
      /note="Leptinrezeptor Isoform A"
      /organism="Homo sapiens"

<400> 5
Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                   15    
Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                   25                  30        
Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                   40                  45            
Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                   55                  60                
Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                   70                  75                  80
Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                   90                  95    
Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                  105                110        
Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                  120                125            
Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                  135                140                
Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                  150                155                  160
Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                  170                175    
Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                  185                190        
Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                  200                205            
Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                  215                220                
Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                  230                235                  240
Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                  250                255    
Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                  265                270        
Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                  280                285            
Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                  295                300                
Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                  310                315                  320
Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                  330                335    
Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                  345                350        
Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                  360                365            
Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                  375                380                
Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                  390                395                  400
Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                  410                415    
Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                  425                430        
Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                  440                445            
Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                  455                460                
Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                  470                475                  480
Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                  490                495    
Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                  505                510        
Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                  520                525            
Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                  535                540                
Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                  550                555                  560
Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                  570                575    
Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                  585                590        
Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                  600                605            
Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                  615                620                
Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                  630                635                  640
Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                  650                655    
Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                  665                670        
Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                  680                685            
Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                  695                700                
Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                  710                715                  720
Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                  730                735    
Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                  745                750        
Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                  760                765            
Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                  775                780                
Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                  790                795                  800
Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                  810                815    
Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                  825                830        
Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                  840                845            
Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                  855                860                
Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                  870                875                  880
Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Arg Thr Asp Ile Leu 
                885                  890                895    

<210> 6
<211> 1165
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..1165
<223> /mol_type="protein"
      /note="Leptinrezeptor Isoform B"
      /organism="Homo sapiens"

<400> 6
Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                   15    
Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                   25                  30        
Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                   40                  45            
Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                   55                  60                
Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                   70                  75                  80
Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                   90                  95    
Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                  105                110        
Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                  120                125            
Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                  135                140                
Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                  150                155                  160
Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                  170                175    
Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                  185                190        
Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                  200                205            
Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                  215                220                
Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                  230                235                  240
Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                  250                255    
Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                  265                270        
Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                  280                285            
Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                  295                300                
Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                  310                315                  320
Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                  330                335    
Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                  345                350        
Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                  360                365            
Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                  375                380                
Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                  390                395                  400
Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                  410                415    
Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                  425                430        
Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                  440                445            
Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                  455                460                
Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                  470                475                  480
Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                  490                495    
Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                  505                510        
Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                  520                525            
Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                  535                540                
Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                  550                555                  560
Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                  570                575    
Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                  585                590        
Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                  600                605            
Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                  615                620                
Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                  630                635                  640
Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                  650                655    
Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                  665                670        
Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                  680                685            
Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                  695                700                
Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                  710                715                  720
Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                  730                735    
Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                  745                750        
Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                  760                765            
Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                  775                780                
Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                  790                795                  800
Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                  810                815    
Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                  825                830        
Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                  840                845            
Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                  855                860                
Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                  870                875                  880
Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Pro Glu Thr Phe Glu 
                885                  890                895    
His Leu Phe Ile Lys His Thr Ala Ser Val Thr Cys Gly Pro Leu Leu 
            900                  905                910        
Leu Glu Pro Glu Thr Ile Ser Glu Asp Ile Ser Val Asp Thr Ser Trp 
        915                  920                925            
Lys Asn Lys Asp Glu Met Met Pro Thr Thr Val Val Ser Leu Leu Ser 
    930                  935                940                
Thr Thr Asp Leu Glu Lys Gly Ser Val Cys Ile Ser Asp Gln Phe Asn 
945                  950                955                  960
Ser Val Asn Phe Ser Glu Ala Glu Gly Thr Glu Val Thr Tyr Glu Asp 
                965                  970                975    
Glu Ser Gln Arg Gln Pro Phe Val Lys Tyr Ala Thr Leu Ile Ser Asn 
            980                  985                990        
Ser Lys Pro Ser Glu Thr Gly Glu Glu Gln Gly Leu Ile Asn Ser Ser 
        995                  1000                1005            
Val Thr Lys Cys Phe Ser Ser Lys Asn Ser Pro Leu Lys Asp Ser Phe 
    1010                1015                1020                
Ser Asn Ser Ser Trp Glu Ile Glu Ala Gln Ala Phe Phe Ile Leu Ser 
1025                1030                1035                1040
Asp Gln His Pro Asn Ile Ile Ser Pro His Leu Thr Phe Ser Glu Gly 
                1045                1050                1055    
Leu Asp Glu Leu Leu Lys Leu Glu Gly Asn Phe Pro Glu Glu Asn Asn 
            1060                1065                1070        
Asp Lys Lys Ser Ile Tyr Tyr Leu Gly Val Thr Ser Ile Lys Lys Arg 
        1075                1080                1085            
Glu Ser Gly Val Leu Leu Thr Asp Lys Ser Arg Val Ser Cys Pro Phe 
    1090                1095                1100                
Pro Ala Pro Cys Leu Phe Thr Asp Ile Arg Val Leu Gln Asp Ser Cys 
1105                1110                1115                1120
Ser His Phe Val Glu Asn Asn Ile Asn Leu Gly Thr Ser Ser Lys Lys 
                1125                1130                1135    
Thr Phe Ala Ser Tyr Met Pro Gln Phe Gln Thr Cys Ser Thr Gln Thr 
            1140                1145                1150        
His Lys Ile Met Glu Asn Lys Met Cys Asp Leu Thr Val 
        1155                1160                1165

<210> 7
<211> 958
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..958
<223> /mol_type="protein"
      /note="Leptinrezeptor Isoform C"
      /organism="Homo sapiens"

<400> 7
Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                   15    
Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                   25                  30        
Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                   40                  45            
Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                   55                  60                
Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                   70                  75                  80
Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                   90                  95    
Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                  105                110        
Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                  120                125            
Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                  135                140                
Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                  150                155                  160
Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                  170                175    
Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                  185                190        
Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                  200                205            
Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                  215                220                
Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                  230                235                  240
Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                  250                255    
Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                  265                270        
Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                  280                285            
Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                  295                300                
Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                  310                315                  320
Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                  330                335    
Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                  345                350        
Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                  360                365            
Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                  375                380                
Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                  390                395                  400
Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                  410                415    
Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                  425                430        
Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                  440                445            
Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                  455                460                
Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                  470                475                  480
Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                  490                495    
Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                  505                510        
Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                  520                525            
Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                  535                540                
Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                  550                555                  560
Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                  570                575    
Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                  585                590        
Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                  600                605            
Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                  615                620                
Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                  630                635                  640
Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                  650                655    
Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                  665                670        
Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                  680                685            
Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                  695                700                
Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                  710                715                  720
Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                  730                735    
Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                  745                750        
Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                  760                765            
Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                  775                780                
Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                  790                795                  800
Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                  810                815    
Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                  825                830        
Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                  840                845            
Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                  855                860                
Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                  870                875                  880
Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Met Leu Glu Gly Ser 
                885                  890                895    
Met Phe Val Lys Ser His His His Ser Leu Ile Ser Ser Thr Gln Gly 
            900                  905                910        
His Lys His Cys Gly Arg Pro Gln Gly Pro Leu His Arg Lys Thr Arg 
        915                  920                925            
Asp Leu Cys Ser Leu Val Tyr Leu Leu Thr Leu Pro Pro Leu Leu Ser 
    930                  935                940                
Tyr Asp Pro Ala Lys Ser Pro Ser Val Arg Asn Thr Gln Glu 
945                  950                955            

<210> 8
<211> 906
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..906
<223> /mol_type="protein"
      /note="Leptinrezeptor Isoform D"
      /organism="Homo sapiens"

<400> 8
Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                   15    
Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                   25                  30        
Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                   40                  45            
Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                   55                  60                
Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                   70                  75                  80
Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                   90                  95    
Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                  105                110        
Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                  120                125            
Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                  135                140                
Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                  150                155                  160
Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                  170                175    
Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                  185                190        
Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                  200                205            
Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                  215                220                
Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                  230                235                  240
Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                  250                255    
Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                  265                270        
Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                  280                285            
Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                  295                300                
Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                  310                315                  320
Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                  330                335    
Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                  345                350        
Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                  360                365            
Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                  375                380                
Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                  390                395                  400
Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                  410                415    
Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                  425                430        
Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                  440                445            
Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                  455                460                
Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                  470                475                  480
Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                  490                495    
Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                  505                510        
Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                  520                525            
Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                  535                540                
Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                  550                555                  560
Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                  570                575    
Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                  585                590        
Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                  600                605            
Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                  615                620                
Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                  630                635                  640
Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                  650                655    
Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                  665                670        
Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                  680                685            
Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                  695                700                
Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                  710                715                  720
Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                  730                735    
Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                  745                750        
Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                  760                765            
Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                  775                780                
Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                  790                795                  800
Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                  810                815    
Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                  825                830        
Ile Glu Lys His Gln Ser Asp Ala Gly Leu Tyr Val Ile Val Pro Val 
        835                  840                845            
Ile Ile Ser Ser Ser Ile Leu Leu Leu Gly Thr Leu Leu Ile Ser His 
    850                  855                860                
Gln Arg Met Lys Lys Leu Phe Trp Glu Asp Val Pro Asn Pro Lys Asn 
865                  870                875                  880
Cys Ser Trp Ala Gln Gly Leu Asn Phe Gln Lys Lys Met Pro Gly Thr 
                885                  890                895    
Lys Glu Leu Leu Gly Gly Gly Trp Leu Thr 
            900                  905    

<210> 9
<211> 839
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..839
<223> /mol_type="protein"
      /note="Leptinrezeptor Isoform E"
      /organism="Homo sapiens"

<400> 9
Met Ile Cys Gln Lys Phe Cys Val Val Leu Leu His Trp Glu Phe Ile 
1               5                   10                   15    
Tyr Val Ile Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg 
            20                   25                  30        
Phe Lys Leu Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu 
        35                   40                  45            
Leu Pro Ala Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr 
    50                   55                  60                
Glu Thr Ala Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser 
65                   70                  75                  80
Asn Leu Ser Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp 
                85                   90                  95    
Arg Asn Cys Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val 
            100                  105                110        
Ser Thr Val Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn 
        115                  120                125            
Ile Gln Cys Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val 
    130                  135                140                
Glu Ser Leu Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His 
145                  150                155                  160
Leu Leu Tyr Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro 
                165                  170                175    
Gln Lys Gly Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu 
            180                  185                190        
Cys Cys Glu Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr 
        195                  200                205            
Leu Leu Met Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser 
    210                  215                220                
Pro Leu Met Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro 
225                  230                235                  240
Leu Gly Leu His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser 
                245                  250                255    
Trp Ser Ser Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys 
            260                  265                270        
Tyr Ser Glu Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val 
        275                  280                285            
Ser Ala Thr Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr 
    290                  295                300                
Glu Val Gln Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser 
305                  310                315                  320
Asp Trp Ser Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe 
                325                  330                335    
Pro Pro Lys Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys 
            340                  345                350        
Ile Tyr Lys Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp 
        355                  360                365            
Trp Met Asn Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val 
    370                  375                380                
Ser Asp His Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys 
385                  390                395                  400
Pro Arg Gly Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His 
                405                  410                415    
Glu Cys His His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile 
            420                  425                430        
Asn Ile Ser Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg 
        435                  440                445            
Trp Ser Thr Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu 
    450                  455                460                
Arg Tyr His Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His 
465                  470                475                  480
Pro Ile Ser Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr 
                485                  490                495    
Glu Cys Ile Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp 
            500                  505                510        
Ile Arg Ile Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys 
        515                  520                525            
Val Leu Pro Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys 
    530                  535                540                
Ala Glu Ile Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys 
545                  550                555                  560
Pro Val Phe Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu 
                565                  570                575    
Ser Gly Lys Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys 
            580                  585                590        
Ser Lys Ser Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala 
        595                  600                605            
Val Gln Val Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn 
    610                  615                620                
Trp Ser Asn Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met 
625                  630                635                  640
Arg Gly Pro Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys 
                645                  650                655    
Glu Lys Asn Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser 
            660                  665                670        
Leu Cys Ser Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn 
        675                  680                685            
Gly Thr Trp Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu 
    690                  695                700                
Trp Thr Glu Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile 
705                  710                715                  720
Gly Ala Ser Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser 
                725                  730                735    
Lys Val Asn Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser 
            740                  745                750        
Cys Val Ile Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met 
        755                  760                765            
Tyr Phe Ile Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys 
    770                  775                780                
Trp Leu Arg Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His 
785                  790                795                  800
Phe Ile Pro Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met 
                805                  810                815    
Glu Gly Val Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp 
            820                  825                830        
Ile Glu Lys His Gln Ser Asp 
        835                

<210> 10
<211> 820
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..820
<223> /mol_type="protein"
      /note="Leptinrezeptor Isoform B Fragment Thr20 - Asp839"
      /organism="Homo sapiens"

<400> 10
Thr Ala Phe Asn Leu Ser Tyr Pro Ile Thr Pro Trp Arg Phe Lys Leu 
1               5                   10                   15    
Ser Cys Met Pro Pro Asn Ser Thr Tyr Asp Tyr Phe Leu Leu Pro Ala 
            20                   25                  30        
Gly Leu Ser Lys Asn Thr Ser Asn Ser Asn Gly His Tyr Glu Thr Ala 
        35                   40                  45            
Val Glu Pro Lys Phe Asn Ser Ser Gly Thr His Phe Ser Asn Leu Ser 
    50                   55                  60                
Lys Thr Thr Phe His Cys Cys Phe Arg Ser Glu Gln Asp Arg Asn Cys 
65                   70                  75                  80
Ser Leu Cys Ala Asp Asn Ile Glu Gly Lys Thr Phe Val Ser Thr Val 
                85                   90                  95    
Asn Ser Leu Val Phe Gln Gln Ile Asp Ala Asn Trp Asn Ile Gln Cys 
            100                  105                110        
Trp Leu Lys Gly Asp Leu Lys Leu Phe Ile Cys Tyr Val Glu Ser Leu 
        115                  120                125            
Phe Lys Asn Leu Phe Arg Asn Tyr Asn Tyr Lys Val His Leu Leu Tyr 
    130                  135                140                
Val Leu Pro Glu Val Leu Glu Asp Ser Pro Leu Val Pro Gln Lys Gly 
145                  150                155                  160
Ser Phe Gln Met Val His Cys Asn Cys Ser Val His Glu Cys Cys Glu 
                165                  170                175    
Cys Leu Val Pro Val Pro Thr Ala Lys Leu Asn Asp Thr Leu Leu Met 
            180                  185                190        
Cys Leu Lys Ile Thr Ser Gly Gly Val Ile Phe Gln Ser Pro Leu Met 
        195                  200                205            
Ser Val Gln Pro Ile Asn Met Val Lys Pro Asp Pro Pro Leu Gly Leu 
    210                  215                220                
His Met Glu Ile Thr Asp Asp Gly Asn Leu Lys Ile Ser Trp Ser Ser 
225                  230                235                  240
Pro Pro Leu Val Pro Phe Pro Leu Gln Tyr Gln Val Lys Tyr Ser Glu 
                245                  250                255    
Asn Ser Thr Thr Val Ile Arg Glu Ala Asp Lys Ile Val Ser Ala Thr 
            260                  265                270        
Ser Leu Leu Val Asp Ser Ile Leu Pro Gly Ser Ser Tyr Glu Val Gln 
        275                  280                285            
Val Arg Gly Lys Arg Leu Asp Gly Pro Gly Ile Trp Ser Asp Trp Ser 
    290                  295                300                
Thr Pro Arg Val Phe Thr Thr Gln Asp Val Ile Tyr Phe Pro Pro Lys 
305                  310                315                  320
Ile Leu Thr Ser Val Gly Ser Asn Val Ser Phe His Cys Ile Tyr Lys 
                325                  330                335    
Lys Glu Asn Lys Ile Val Pro Ser Lys Glu Ile Val Trp Trp Met Asn 
            340                  345                350        
Leu Ala Glu Lys Ile Pro Gln Ser Gln Tyr Asp Val Val Ser Asp His 
        355                  360                365            
Val Ser Lys Val Thr Phe Phe Asn Leu Asn Glu Thr Lys Pro Arg Gly 
    370                  375                380                
Lys Phe Thr Tyr Asp Ala Val Tyr Cys Cys Asn Glu His Glu Cys His 
385                  390                395                  400
His Arg Tyr Ala Glu Leu Tyr Val Ile Asp Val Asn Ile Asn Ile Ser 
                405                  410                415    
Cys Glu Thr Asp Gly Tyr Leu Thr Lys Met Thr Cys Arg Trp Ser Thr 
            420                  425                430        
Ser Thr Ile Gln Ser Leu Ala Glu Ser Thr Leu Gln Leu Arg Tyr His 
        435                  440                445            
Arg Ser Ser Leu Tyr Cys Ser Asp Ile Pro Ser Ile His Pro Ile Ser 
    450                  455                460                
Glu Pro Lys Asp Cys Tyr Leu Gln Ser Asp Gly Phe Tyr Glu Cys Ile 
465                  470                475                  480
Phe Gln Pro Ile Phe Leu Leu Ser Gly Tyr Thr Met Trp Ile Arg Ile 
                485                  490                495    
Asn His Ser Leu Gly Ser Leu Asp Ser Pro Pro Thr Cys Val Leu Pro 
            500                  505                510        
Asp Ser Val Val Lys Pro Leu Pro Pro Ser Ser Val Lys Ala Glu Ile 
        515                  520                525            
Thr Ile Asn Ile Gly Leu Leu Lys Ile Ser Trp Glu Lys Pro Val Phe 
    530                  535                540                
Pro Glu Asn Asn Leu Gln Phe Gln Ile Arg Tyr Gly Leu Ser Gly Lys 
545                  550                555                  560
Glu Val Gln Trp Lys Met Tyr Glu Val Tyr Asp Ala Lys Ser Lys Ser 
                565                  570                575    
Val Ser Leu Pro Val Pro Asp Leu Cys Ala Val Tyr Ala Val Gln Val 
            580                  585                590        
Arg Cys Lys Arg Leu Asp Gly Leu Gly Tyr Trp Ser Asn Trp Ser Asn 
        595                  600                605            
Pro Ala Tyr Thr Val Val Met Asp Ile Lys Val Pro Met Arg Gly Pro 
    610                  615                620                
Glu Phe Trp Arg Ile Ile Asn Gly Asp Thr Met Lys Lys Glu Lys Asn 
625                  630                635                  640
Val Thr Leu Leu Trp Lys Pro Leu Met Lys Asn Asp Ser Leu Cys Ser 
                645                  650                655    
Val Gln Arg Tyr Val Ile Asn His His Thr Ser Cys Asn Gly Thr Trp 
            660                  665                670        
Ser Glu Asp Val Gly Asn His Thr Lys Phe Thr Phe Leu Trp Thr Glu 
        675                  680                685            
Gln Ala His Thr Val Thr Val Leu Ala Ile Asn Ser Ile Gly Ala Ser 
    690                  695                700                
Val Ala Asn Phe Asn Leu Thr Phe Ser Trp Pro Met Ser Lys Val Asn 
705                  710                715                  720
Ile Val Gln Ser Leu Ser Ala Tyr Pro Leu Asn Ser Ser Cys Val Ile 
                725                  730                735    
Val Ser Trp Ile Leu Ser Pro Ser Asp Tyr Lys Leu Met Tyr Phe Ile 
            740                  745                750        
Ile Glu Trp Lys Asn Leu Asn Glu Asp Gly Glu Ile Lys Trp Leu Arg 
        755                  760                765            
Ile Ser Ser Ser Val Lys Lys Tyr Tyr Ile His Asp His Phe Ile Pro 
    770                  775                780                
Ile Glu Lys Tyr Gln Phe Ser Leu Tyr Pro Ile Phe Met Glu Gly Val 
785                  790                795                  800
Gly Lys Pro Lys Ile Ile Asn Ser Phe Thr Gln Asp Asp Ile Glu Lys 
                805                  810                815    
His Gln Ser Asp 
            820

