                         SEQUENCE LISTING

<110>  Schulze, Dan
 
<120>  UNIVERSAL ANTIBODY-MEDIATED BIOSENSOR

<130>  2016-0324A

<150>  US 62/132,729
<151>  2015-03-13

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  320
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


<210>  2
<211>  233
<212>  PRT
<213>  Mus musculus

<400>  2

Met Thr Leu Asp Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
1               5                   10                  15      


Trp Leu Leu Pro Pro Leu Thr Ile Leu Leu Leu Phe Ala Phe Ala Asp 
            20                  25                  30          


Arg Gln Ser Ala Ala Leu Pro Lys Ala Val Val Lys Leu Asp Pro Pro 
        35                  40                  45              


Trp Ile Gln Val Leu Lys Glu Asp Met Val Thr Leu Met Cys Glu Gly 
    50                  55                  60                  


Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Trp Ser 
65                  70                  75                  80  


Ser Ile Arg Ser Gln Val Gln Ser Ser Tyr Thr Phe Lys Ala Thr Val 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser 
            100                 105                 110         


Asp Pro Val Asp Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
        115                 120                 125             


Pro Gln Arg Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys Pro 
    130                 135                 140                 


Ser Trp Arg Asn Lys Leu Leu Asn Arg Ile Ser Phe Phe His Asn Glu 
145                 150                 155                 160 


Lys Ser Val Arg Tyr His His Tyr Lys Ser Asn Phe Ser Ile Pro Lys 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly 
            180                 185                 190         


Ser Thr Gln His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Asp Pro 
        195                 200                 205             


Ala Thr Thr Ser Ser Ile Ser Leu Val Trp His His Thr Ala Phe Ser 
    210                 215                 220                 


Leu Val Met Cys Leu Leu Phe Ala Val 
225                 230             


<210>  3
<211>  286
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu 
        275                 280                 285     


<210>  4
<211>  207
<212>  PRT
<213>  Mus musculus

<400>  4

Met Thr Leu Asp Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
1               5                   10                  15      


Trp Leu Leu Pro Pro Leu Thr Ile Leu Leu Leu Phe Ala Phe Ala Asp 
            20                  25                  30          


Arg Gln Ser Ala Ala Leu Pro Lys Ala Val Val Lys Leu Asp Pro Pro 
        35                  40                  45              


Trp Ile Gln Val Leu Lys Glu Asp Met Val Thr Leu Met Cys Glu Gly 
    50                  55                  60                  


Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Trp Ser 
65                  70                  75                  80  


Ser Ile Arg Ser Gln Val Gln Ser Ser Tyr Thr Phe Lys Ala Thr Val 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser 
            100                 105                 110         


Asp Pro Val Asp Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
        115                 120                 125             


Pro Gln Arg Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys Pro 
    130                 135                 140                 


Ser Trp Arg Asn Lys Leu Leu Asn Arg Ile Ser Phe Phe His Asn Glu 
145                 150                 155                 160 


Lys Ser Val Arg Tyr His His Tyr Lys Ser Asn Phe Ser Ile Pro Lys 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly 
            180                 185                 190         


Ser Thr Gln His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Asp 
        195                 200                 205         


<210>  5
<211>  62
<212>  PRT
<213>  Mus musculus

<400>  5

Phe Arg Lys Arg Trp Gln Asn Glu Lys Phe Gly Val Asp Met Pro Asp 
1               5                   10                  15      


Asp Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys 
            20                  25                  30          


Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp 
        35                  40                  45              


Val Gly Asn Leu His Ile Gly Asp Ala Gln Leu Glu Lys Pro 
    50                  55                  60          


<210>  6
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly 
225                 230                 235                 240 


Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe 
                245                 250                 255     


Leu Leu Ser Val Cys Tyr Ser Ala Thr Ile Thr Phe Phe Lys Val Lys 
            260                 265                 270         


Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp 
        275                 280                 285             


Tyr Arg Asn Met Ile Arg Gln Gly Ala 
    290                 295         


<210>  7
<211>  1149
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRI and Ig 
       alpha

<400>  7
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960

ttcaggaaac ggtggcaaaa tgagaagttt ggggtggaca tgccagatga ctatgaagat     1020

gaaaatctct atgagggcct gaaccttgat gactgttcta tgtatgagga catctccagg     1080

ggactccagg gcacctacca ggatgtgggc aacctccaca ttggagatgc ccagctggaa     1140

aagccatga                                                             1149


<210>  8
<211>  382
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRI and Ig 
       alpha

<400>  8

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln 
        275                 280                 285             


Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe 
    290                 295                 300                 


Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val 
305                 310                 315                 320 


Phe Arg Lys Arg Trp Gln Asn Glu Lys Phe Gly Val Asp Met Pro Asp 
                325                 330                 335     


Asp Tyr Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys 
            340                 345                 350         


Ser Met Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp 
        355                 360                 365             


Val Gly Asn Leu His Ile Gly Asp Ala Gln Leu Glu Lys Pro 
    370                 375                 380         


<210>  9
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRIII and Ig 
       alpha

<400>  9
atgactttgg acacccagat gtttcagaat gcacactctg gaagccaatg gctacttcca       60

ccactgacaa ttctgctgct gtttgctttt gcagacaggc agagtgcagc tcttccgaag      120

gctgtggtga aactggaccc cccatggatc caggtgctca aggaagacat ggtgacactg      180

atgtgcgaag ggacccacaa ccctgggaac tcttctactc agtggttcca caactggagt      240

tccatccgga gccaggtcca atccagctac acgtttaagg ccacagtcaa tgacagtgga      300

gaatatcggt gtcaaatgga gcagacccgc ctcagcgacc ctgtagatct gggagtgatt      360

tctgactggc tgctgctcca gacccctcag cgggtgtttc tggaagggga aaccatcacg      420

ctaaggtgcc ctagctggag gaacaaacta ctgaacagga tctcgttctt ccataatgaa      480

aaatccgtga ggtatcatca ctacaaaagt aatttctcta tcccaaaagc caaccacagt      540

cacagtgggg actactactg caaaggaagt ctaggaagta cacagcacca gtccaagcct      600

gtcaccatca ctgtccaaga cccagcaact acatcctcca tctctctagt ctggcaccac      660

actgctttct ccctagtgat gtgcctcctg tttgcagtgt tcaggaaacg gtggcaaaat      720

gagaagtttg gggtggacat gccagatgac tatgaagatg aaaatctcta tgagggcctg      780

aaccttgatg actgttctat gtatgaggac atctccaggg gactccaggg cacctaccag      840

gatgtgggca acctccacat tggagatgcc cagctggaaa agccatga                   888


<210>  10
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRIII and Ig 
       alpha

<400>  10

Met Thr Leu Asp Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
1               5                   10                  15      


Trp Leu Leu Pro Pro Leu Thr Ile Leu Leu Leu Phe Ala Phe Ala Asp 
            20                  25                  30          


Arg Gln Ser Ala Ala Leu Pro Lys Ala Val Val Lys Leu Asp Pro Pro 
        35                  40                  45              


Trp Ile Gln Val Leu Lys Glu Asp Met Val Thr Leu Met Cys Glu Gly 
    50                  55                  60                  


Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Trp Ser 
65                  70                  75                  80  


Ser Ile Arg Ser Gln Val Gln Ser Ser Tyr Thr Phe Lys Ala Thr Val 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser 
            100                 105                 110         


Asp Pro Val Asp Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
        115                 120                 125             


Pro Gln Arg Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys Pro 
    130                 135                 140                 


Ser Trp Arg Asn Lys Leu Leu Asn Arg Ile Ser Phe Phe His Asn Glu 
145                 150                 155                 160 


Lys Ser Val Arg Tyr His His Tyr Lys Ser Asn Phe Ser Ile Pro Lys 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly 
            180                 185                 190         


Ser Thr Gln His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Asp Pro 
        195                 200                 205             


Ala Thr Thr Ser Ser Ile Ser Leu Val Trp His His Thr Ala Phe Ser 
    210                 215                 220                 


Leu Val Met Cys Leu Leu Phe Ala Val Phe Arg Lys Arg Trp Gln Asn 
225                 230                 235                 240 


Glu Lys Phe Gly Val Asp Met Pro Asp Asp Tyr Glu Asp Glu Asn Leu 
                245                 250                 255     


Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met Tyr Glu Asp Ile Ser 
            260                 265                 270         


Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly Asn Leu His Ile Gly 
        275                 280                 285             


Asp Ala Gln Leu Glu Lys Pro 
    290                 295 


<210>  11
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRI and 
       membrane Ig

<400>  11
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagga gcgcaaatgt tgtgtcgagt gcccaccgtg cccagcacca      900

cctgtggcag gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      960

tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga gccacgaaga ccccgaggtc     1020

cagttcaact ggtacgtgga cggcatggag gtgcataatg ccaagacaaa gccacgggag     1080

gagcagttca acagcacgtt ccgtgtggtc agcgtcctca ccgtcgtgca ccaggactgg     1140

ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag gcctcccagc ccccatcgag     1200

aaaaccatct ccaaaaccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1260

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac     1320

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1380

acacctccca tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1440

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1500

aaccactaca cacagaagag cctctccctg tctccggagc tgcaactgga ggagagctgt     1560

gcggaggcgc aggacgggga gctggacggg ctgtggacga ccatcaccat cttcatcaca     1620

ctcttcctgc taagcgtgtg ctacagtgcc accatcacct tcttcaaggt gaagtggatc     1680

ttctcctcag tggtggacct gaagcagacc atcgtccccg actacaggaa catgatcagg     1740

cagggggcct ag                                                         1752


<210>  12
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRI and 
       membrane Ig

<400>  12

Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu 
1               5                   10                  15      


Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala 
            20                  25                  30          


Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn 
        35                  40                  45              


Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr 
    50                  55                  60                  


Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr 
65                  70                  75                  80  


Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln 
                85                  90                  95      


Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn 
            100                 105                 110         


Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu 
        115                 120                 125             


Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn 
    130                 135                 140                 


Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser 
145                 150                 155                 160 


Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His 
                165                 170                 175     


Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile 
            180                 185                 190         


Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser 
        195                 200                 205             


Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn 
    210                 215                 220                 


Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val 
225                 230                 235                 240 


Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile 
                245                 250                 255     


Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala 
            260                 265                 270         


Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Glu Arg 
        275                 280                 285             


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
    290                 295                 300                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
305                 310                 315                 320 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                325                 330                 335     


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val His 
            340                 345                 350         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
        355                 360                 365             


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
    370                 375                 380                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
385                 390                 395                 400 


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                405                 410                 415     


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
            420                 425                 430         


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        435                 440                 445             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
    450                 455                 460                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
465                 470                 475                 480 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                485                 490                 495     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            500                 505                 510         


Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu 
        515                 520                 525             


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu 
    530                 535                 540                 


Ser Val Cys Tyr Ser Ala Thr Ile Thr Phe Phe Lys Val Lys Trp Ile 
545                 550                 555                 560 


Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp Tyr Arg 
                565                 570                 575     


Asn Met Ile Arg Gln Gly Ala 
            580             


<210>  13
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRIII and 
       membrane Ig

<400>  13
atgactttgg acacccagat gtttcagaat gcacactctg gaagccaatg gctacttcca       60

ccactgacaa ttctgctgct gtttgctttt gcagacaggc agagtgcagc tcttccgaag      120

gctgtggtga aactggaccc cccatggatc caggtgctca aggaagacat ggtgacactg      180

atgtgcgaag ggacccacaa ccctgggaac tcttctactc agtggttcca caactggagt      240

tccatccgga gccaggtcca atccagctac acgtttaagg ccacagtcaa tgacagtgga      300

gaatatcggt gtcaaatgga gcagacccgc ctcagcgacc ctgtagatct gggagtgatt      360

tctgactggc tgctgctcca gacccctcag cgggtgtttc tggaagggga aaccatcacg      420

ctaaggtgcc ctagctggag gaacaaacta ctgaacagga tctcgttctt ccataatgaa      480

aaatccgtga ggtatcatca ctacaaaagt aatttctcta tcccaaaagc caaccacagt      540

cacagtgggg actactactg caaaggaagt ctaggaagta cacagcacca gtccaagcct      600

gtcaccatca ctgtccaaga cgagcgcaaa tgttgtgtcg agtgcccacc gtgcccagca      660

ccacctgtgg caggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      720

atctcccgga cccctgaggt cacgtgcgtg gtggtggacg tgagccacga agaccccgag      780

gtccagttca actggtacgt ggacggcatg gaggtgcata atgccaagac aaagccacgg      840

gaggagcagt tcaacagcac gttccgtgtg gtcagcgtcc tcaccgtcgt gcaccaggac      900

tggctgaacg gcaaggagta caagtgcaag gtctccaaca aaggcctccc agcccccatc      960

gagaaaacca tctccaaaac caaagggcag ccccgagaac cacaggtgta caccctgccc     1020

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1080

taccccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1140

accacacctc ccatgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1200

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1260

cacaaccact acacacagaa gagcctctcc ctgtctccgg agctgcaact ggaggagagc     1320

tgtgcggagg cgcaggacgg ggagctggac gggctgtgga cgaccatcac catcttcatc     1380

acactcttcc tgctaagcgt gtgctacagt gccaccatca ccttcttcaa ggtgaagtgg     1440

atcttctcct cagtggtgga cctgaagcag accatcgtcc ccgactacag gaacatgatc     1500

aggcaggggg cctag                                                      1515


<210>  14
<211>  504
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRIII and 
       membrane Ig

<400>  14

Met Thr Leu Asp Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln 
1               5                   10                  15      


Trp Leu Leu Pro Pro Leu Thr Ile Leu Leu Leu Phe Ala Phe Ala Asp 
            20                  25                  30          


Arg Gln Ser Ala Ala Leu Pro Lys Ala Val Val Lys Leu Asp Pro Pro 
        35                  40                  45              


Trp Ile Gln Val Leu Lys Glu Asp Met Val Thr Leu Met Cys Glu Gly 
    50                  55                  60                  


Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Trp Ser 
65                  70                  75                  80  


Ser Ile Arg Ser Gln Val Gln Ser Ser Tyr Thr Phe Lys Ala Thr Val 
                85                  90                  95      


Asn Asp Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser 
            100                 105                 110         


Asp Pro Val Asp Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr 
        115                 120                 125             


Pro Gln Arg Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys Pro 
    130                 135                 140                 


Ser Trp Arg Asn Lys Leu Leu Asn Arg Ile Ser Phe Phe His Asn Glu 
145                 150                 155                 160 


Lys Ser Val Arg Tyr His His Tyr Lys Ser Asn Phe Ser Ile Pro Lys 
                165                 170                 175     


Ala Asn His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly 
            180                 185                 190         


Ser Thr Gln His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Asp Glu 
        195                 200                 205             


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
    210                 215                 220                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
225                 230                 235                 240 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                245                 250                 255     


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val 
            260                 265                 270         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
        275                 280                 285             


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
    290                 295                 300                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
305                 310                 315                 320 


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
                325                 330                 335     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            340                 345                 350         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        355                 360                 365             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    370                 375                 380                 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
385                 390                 395                 400 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                405                 410                 415     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            420                 425                 430         


Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu 
        435                 440                 445             


Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu 
    450                 455                 460                 


Leu Ser Val Cys Tyr Ser Ala Thr Ile Thr Phe Phe Lys Val Lys Trp 
465                 470                 475                 480 


Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp Tyr 
                485                 490                 495     


Arg Asn Met Ile Arg Gln Gly Ala 
            500                 


<210>  15
<211>  1215
<212>  DNA
<213>  Mus musculus


<220>
<221>  exon
<222>  (1)..(1212)

<400>  15
atg att ctt acc agc ttt gga gat gac atg tgg ctt cta aca act ctg         48
Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu           
1               5                   10                  15                

cta ctt tgg gtt cca gtc ggt ggg gaa gtg gtt aat gcc acc aag gct         96
Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala           
            20                  25                  30                    

gtg atc acc ttg cag cct cca tgg gtc agt att ttc cag aag gaa aat        144
Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn           
        35                  40                  45                        

gtc act tta tgg tgt gag ggg cct cac ctg cct gga gac agt tcc aca        192
Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr           
    50                  55                  60                            

caa tgg ttt atc aac gga aca gcc gtt cag atc tcc acg cct agt tat        240
Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr           
65                  70                  75                  80            

agc atc cca gag gcc agt ttt cag gac agt ggc gaa tac agg tgt cag        288
Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln           
                85                  90                  95                

ata ggt tcc tca atg cca agt gac cct gtg cag ttg caa atc cac aat        336
Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn           
            100                 105                 110                   

gat tgg ctg cta ctc cag gcc tcc cgc aga gtc ctc aca gaa gga gaa        384
Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu           
        115                 120                 125                       

ccc ctg gcc ttg agg tgt cac gga tgg aag aat aaa ctg gtg tac aat        432
Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn           
    130                 135                 140                           

gtg gtt ttc tat aga aat gga aaa tcc ttt cag ttt tct tca gat tcg        480
Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser           
145                 150                 155                 160           

gag gtc gcc att ctg aaa acc aac ctg agt cac agc ggc atc tac cac        528
Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His           
                165                 170                 175               

tgc tca ggc acg gga aga cac cgc tac aca tct gca gga gtg tcc atc        576
Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile           
            180                 185                 190                   

acg gtg aaa gag ctg ttt acc acg cca gtg ctg aga gca tcc gtg tca        624
Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser           
        195                 200                 205                       

tct ccc ttc ccg gag ggg agt ctg gtc acc ctg aac tgt gag acg aat        672
Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn           
    210                 215                 220                           

ttg ctc ctg cag aga ccc ggc tta cag ctt cac ttc tcc ttc tac gtg        720
Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val           
225                 230                 235                 240           

ggc agc aag atc ctg gag tac agg aac aca tcc tca gag tac cat ata        768
Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile           
                245                 250                 255               

gca agg gcg gaa aga gaa gat gct gga ttc tac tgg tgt gag gta gcc        816
Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala           
            260                 265                 270                   

acg gag gac agc agt gtc ctt aag cgc agc cct gag ttg gag ctc caa        864
Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Leu Gln           
        275                 280                 285                       

gtg ctt ggt ccc cag tca tca gct cct gtc tgg ttt cac atc ctg ttt        912
Val Leu Gly Pro Gln Ser Ser Ala Pro Val Trp Phe His Ile Leu Phe           
    290                 295                 300                           

tat ctg tca gtg gga ata atg ttt tcg ttg aac acg gtt ctc tat gtg        960
Tyr Leu Ser Val Gly Ile Met Phe Ser Leu Asn Thr Val Leu Tyr Val           
305                 310                 315                 320           

aaa ata cac agg ctg cag aga gag aag aaa tac aac tta gaa gtc cct       1008
Lys Ile His Arg Leu Gln Arg Glu Lys Lys Tyr Asn Leu Glu Val Pro           
                325                 330                 335               

ttg gtt tct gag cag gga aag aaa gca aat tcc ttt cag caa gtt aga       1056
Leu Val Ser Glu Gln Gly Lys Lys Ala Asn Ser Phe Gln Gln Val Arg           
            340                 345                 350                   

agc gat ggc gtg tat gaa gaa gta aca gcc act gcg agc cag acc aca       1104
Ser Asp Gly Val Tyr Glu Glu Val Thr Ala Thr Ala Ser Gln Thr Thr           
        355                 360                 365                       

cca aaa gaa gcg ccc gat gga cct cga agc tca gtg ggt gac tgt gga       1152
Pro Lys Glu Ala Pro Asp Gly Pro Arg Ser Ser Val Gly Asp Cys Gly           
    370                 375                 380                           

ccc gag cag cct gaa ccc ctt cct ccc agt gac agt act ggg gca caa       1200
Pro Glu Gln Pro Glu Pro Leu Pro Pro Ser Asp Ser Thr Gly Ala Gln           
385                 390                 395                 400           

act tcc caa agt tga                                                   1215
Thr Ser Gln Ser                                                           
                                                                          


<210>  16
<211>  804
<212>  DNA
<213>  Mus musculus


<220>
<221>  exon
<222>  (1)..(801)

<400>  16
atg act ttg gac acc cag atg ttt cag aat gca cac tct gga agc caa         48
Met Thr Leu Asp Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln           
1               5                   10                  15                

tgg cta ctt cca cca ctg aca att ctg ctg ctg ttt gct ttt gca gac         96
Trp Leu Leu Pro Pro Leu Thr Ile Leu Leu Leu Phe Ala Phe Ala Asp           
            20                  25                  30                    

agg cag agt gca gct ctt ccg aag gct gtg gtg aaa ctg gac ccc cca        144
Arg Gln Ser Ala Ala Leu Pro Lys Ala Val Val Lys Leu Asp Pro Pro           
        35                  40                  45                        

tgg atc cag gtg ctc aag gaa gac atg gtg aca ctg atg tgc gaa ggg        192
Trp Ile Gln Val Leu Lys Glu Asp Met Val Thr Leu Met Cys Glu Gly           
    50                  55                  60                            

acc cac aac cct ggg aac tct tct act cag tgg ttc cac aac tgg agt        240
Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Trp Ser           
65                  70                  75                  80            

tcc atc cgg agc cag gtc caa tcc agc tac acg ttt aag gcc aca gtc        288
Ser Ile Arg Ser Gln Val Gln Ser Ser Tyr Thr Phe Lys Ala Thr Val           
                85                  90                  95                

aat gac agt gga gaa tat cgg tgt caa atg gag cag acc cgc ctc agc        336
Asn Asp Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser           
            100                 105                 110                   

gac cct gta gat ctg gga gtg att tct gac tgg ctg ctg ctc cag acc        384
Asp Pro Val Asp Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr           
        115                 120                 125                       

cct cag cgg gtg ttt ctg gaa ggg gaa acc atc acg cta agg tgc cct        432
Pro Gln Arg Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys Pro           
    130                 135                 140                           

agc tgg agg aac aaa cta ctg aac agg atc tcg ttc ttc cat aat gaa        480
Ser Trp Arg Asn Lys Leu Leu Asn Arg Ile Ser Phe Phe His Asn Glu           
145                 150                 155                 160           

aaa tcc gtg agg tat cat cac tac aaa agt aat ttc tct atc cca aaa        528
Lys Ser Val Arg Tyr His His Tyr Lys Ser Asn Phe Ser Ile Pro Lys           
                165                 170                 175               

gcc aac cac agt cac agt ggg gac tac tac tgc aaa gga agt cta gga        576
Ala Asn His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly           
            180                 185                 190                   

agt aca cag cac cag tcc aag cct gtc acc atc act gtc caa gac cca        624
Ser Thr Gln His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Asp Pro           
        195                 200                 205                       

gca act aca tcc tcc atc tct cta gtc tgg cac cac act gct ttc tcc        672
Ala Thr Thr Ser Ser Ile Ser Leu Val Trp His His Thr Ala Phe Ser           
    210                 215                 220                           

cta gtg atg tgc ctc ctg ttt gca gtg gac acg ggc ctt tat ttc tat        720
Leu Val Met Cys Leu Leu Phe Ala Val Asp Thr Gly Leu Tyr Phe Tyr           
225                 230                 235                 240           

gta cgg aga aat ctt caa acc ccg agg gat tac tgg agg aag tcc ctg        768
Val Arg Arg Asn Leu Gln Thr Pro Arg Asp Tyr Trp Arg Lys Ser Leu           
                245                 250                 255               

tca atc aga aag cac cag gct cct caa gac aag tga                        804
Ser Ile Arg Lys His Gln Ala Pro Gln Asp Lys                               
            260                 265                                       


<210>  17
<211>  663
<212>  DNA
<213>  Mus musculus


<220>
<221>  exon
<222>  (1)..(660)

<400>  17
atg cca ggg ggt cta gaa gcc ctc aga gcc ctg cct ctc ctc ctc ttc         48
Met Pro Gly Gly Leu Glu Ala Leu Arg Ala Leu Pro Leu Leu Leu Phe           
1               5                   10                  15                

ttg tca tac gcc tgt ttg ggt ccc gga tgc cag gcc ctg cgg gta gaa         96
Leu Ser Tyr Ala Cys Leu Gly Pro Gly Cys Gln Ala Leu Arg Val Glu           
            20                  25                  30                    

ggg ggt cca cca tcc ctg acg gtg aac ttg ggc gag gag gcc cgc ctc        144
Gly Gly Pro Pro Ser Leu Thr Val Asn Leu Gly Glu Glu Ala Arg Leu           
        35                  40                  45                        

acc tgt gaa aac aat ggc agg aac cct aat atc aca tgg tgg ttc agc        192
Thr Cys Glu Asn Asn Gly Arg Asn Pro Asn Ile Thr Trp Trp Phe Ser           
    50                  55                  60                            

ctt cag tct aac atc aca tgg ccc cca gtg cca ctg ggt cct ggc cag        240
Leu Gln Ser Asn Ile Thr Trp Pro Pro Val Pro Leu Gly Pro Gly Gln           
65                  70                  75                  80            

ggt acc aca ggc cag ctg ttc ttc ccc gaa gta aac aag aac cac agg        288
Gly Thr Thr Gly Gln Leu Phe Phe Pro Glu Val Asn Lys Asn His Arg           
                85                  90                  95                

ggc ttg tac tgg tgc caa gtg ata gaa aac aac ata tta aaa cgc tcc        336
Gly Leu Tyr Trp Cys Gln Val Ile Glu Asn Asn Ile Leu Lys Arg Ser           
            100                 105                 110                   

tgt ggt act tac ctc cgc gtg cgc aat cca gtc cct agg ccc ttc ctg        384
Cys Gly Thr Tyr Leu Arg Val Arg Asn Pro Val Pro Arg Pro Phe Leu           
        115                 120                 125                       

gac atg ggg gaa ggt acc aag aac cgc atc atc aca gca gaa ggg atc        432
Asp Met Gly Glu Gly Thr Lys Asn Arg Ile Ile Thr Ala Glu Gly Ile           
    130                 135                 140                           

atc ttg ctg ttc tgt gca gtg gtg cca ggg acg ctg ctg cta ttc agg        480
Ile Leu Leu Phe Cys Ala Val Val Pro Gly Thr Leu Leu Leu Phe Arg           
145                 150                 155                 160           

aaa cgg tgg caa aat gag aag ttt ggg gtg gac atg cca gat gac tat        528
Lys Arg Trp Gln Asn Glu Lys Phe Gly Val Asp Met Pro Asp Asp Tyr           
                165                 170                 175               

gaa gat gaa aat ctc tat gag ggc ctg aac ctt gat gac tgt tct atg        576
Glu Asp Glu Asn Leu Tyr Glu Gly Leu Asn Leu Asp Asp Cys Ser Met           
            180                 185                 190                   

tat gag gac atc tcc agg gga ctc cag ggc acc tac cag gat gtg ggc        624
Tyr Glu Asp Ile Ser Arg Gly Leu Gln Gly Thr Tyr Gln Asp Val Gly           
        195                 200                 205                       

aac ctc cac att gga gat gcc cag ctg gaa aag cca tga                    663
Asn Leu His Ile Gly Asp Ala Gln Leu Glu Lys Pro                           
    210                 215                 220                           


<210>  18
<211>  894
<212>  DNA
<213>  Homo sapiens


<220>
<221>  exon
<222>  (1)..(891)

<400>  18
gag cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg         48
Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val           
1               5                   10                  15                

gca gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc         96
Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu           
            20                  25                  30                    

atg atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc        144
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser           
        35                  40                  45                        

cac gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc atg gag        192
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu           
    50                  55                  60                            

gtg cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg        240
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr           
65                  70                  75                  80            

ttc cgt gtg gtc agc gtc ctc acc gtc gtg cac cag gac tgg ctg aac        288
Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn           
                85                  90                  95                

ggc aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc        336
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro           
            100                 105                 110                   

atc gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag        384
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln           
        115                 120                 125                       

gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc        432
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val           
    130                 135                 140                           

agc ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg        480
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val           
145                 150                 155                 160           

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct        528
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro           
                165                 170                 175               

ccc atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc        576
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr           
            180                 185                 190                   

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg        624
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val           
        195                 200                 205                       

atg cat gag gct ctg cac aac cac tac aca cag aag agc ctc tcc ctg        672
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu           
    210                 215                 220                           

tct ccg gag ctg caa ctg gag gag agc tgt gcg gag gcg cag gac ggg        720
Ser Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly           
225                 230                 235                 240           

gag ctg gac ggg ctg tgg acg acc atc acc atc ttc atc aca ctc ttc        768
Glu Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe           
                245                 250                 255               

ctg cta agc gtg tgc tac agt gcc acc atc acc ttc ttc aag gtg aag        816
Leu Leu Ser Val Cys Tyr Ser Ala Thr Ile Thr Phe Phe Lys Val Lys           
            260                 265                 270                   

tgg atc ttc tcc tca gtg gtg gac ctg aag cag acc atc gtc ccc gac        864
Trp Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp           
        275                 280                 285                       

tac agg aac atg atc agg cag ggg gcc tag                                894
Tyr Arg Asn Met Ile Arg Gln Gly Ala                                       
    290                 295                                               


<210>  19
<211>  960
<212>  DNA
<213>  Mus musculus

<400>  19
atgattctta ccagctttgg agatgacatg tggcttctaa caactctgct actttgggtt       60

ccagtcggtg gggaagtggt taatgccacc aaggctgtga tcaccttgca gcctccatgg      120

gtcagtattt tccagaagga aaatgtcact ttatggtgtg aggggcctca cctgcctgga      180

gacagttcca cacaatggtt tatcaacgga acagccgttc agatctccac gcctagttat      240

agcatcccag aggccagttt tcaggacagt ggcgaataca ggtgtcagat aggttcctca      300

atgccaagtg accctgtgca gttgcaaatc cacaatgatt ggctgctact ccaggcctcc      360

cgcagagtcc tcacagaagg agaacccctg gccttgaggt gtcacggatg gaagaataaa      420

ctggtgtaca atgtggtttt ctatagaaat ggaaaatcct ttcagttttc ttcagattcg      480

gaggtcgcca ttctgaaaac caacctgagt cacagcggca tctaccactg ctcaggcacg      540

ggaagacacc gctacacatc tgcaggagtg tccatcacgg tgaaagagct gtttaccacg      600

ccagtgctga gagcatccgt gtcatctccc ttcccggagg ggagtctggt caccctgaac      660

tgtgagacga atttgctcct gcagagaccc ggcttacagc ttcacttctc cttctacgtg      720

ggcagcaaga tcctggagta caggaacaca tcctcagagt accatatagc aagggcggaa      780

agagaagatg ctggattcta ctggtgtgag gtagccacgg aggacagcag tgtccttaag      840

cgcagccctg agttggagct ccaagtgctt ggtccccagt catcagctcc tgtctggttt      900

cacatcctgt tttatctgtc agtgggaata atgttttcgt tgaacacggt tctctatgtg      960


<210>  20
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  20
atgactttgg acacccagat gtttcagaat gcacactctg gaagccaatg gctacttcca       60

ccactgacaa ttctgctgct gtttgctttt gcagacaggc agagtgcagc tcttccgaag      120

gctgtggtga aactggaccc cccatggatc caggtgctca aggaagacat ggtgacactg      180

atgtgcgaag ggacccacaa ccctgggaac tcttctactc agtggttcca caactggagt      240

tccatccgga gccaggtcca atccagctac acgtttaagg ccacagtcaa tgacagtgga      300

gaatatcggt gtcaaatgga gcagacccgc ctcagcgacc ctgtagatct gggagtgatt      360

tctgactggc tgctgctcca gacccctcag cgggtgtttc tggaagggga aaccatcacg      420

ctaaggtgcc ctagctggag gaacaaacta ctgaacagga tctcgttctt ccataatgaa      480

aaatccgtga ggtatcatca ctacaaaagt aatttctcta tcccaaaagc caaccacagt      540

cacagtgggg actactactg caaaggaagt ctaggaagta cacagcacca gtccaagcct      600

gtcaccatca ctgtccaaga cccagcaact acatcctcca tctctctagt ctggcaccac      660

actgctttct ccctagtgat gtgcctcctg tttgcagtg                             699


<210>  21
<211>  189
<212>  DNA
<213>  Mus musculus

<400>  21
ttcaggaaac ggtggcaaaa tgagaagttt ggggtggaca tgccagatga ctatgaagat       60

gaaaatctct atgagggcct gaaccttgat gactgttcta tgtatgagga catctccagg      120

ggactccagg gcacctacca ggatgtgggc aacctccaca ttggagatgc ccagctggaa      180

aagccatga                                                              189


<210>  22
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRI and 
       membrane Ig


<220>
<221>  exon
<222>  (1)..(1749)

<400>  22
atg att ctt acc agc ttt gga gat gac atg tgg ctt cta aca act ctg         48
Met Ile Leu Thr Ser Phe Gly Asp Asp Met Trp Leu Leu Thr Thr Leu           
1               5                   10                  15                

cta ctt tgg gtt cca gtc ggt ggg gaa gtg gtt aat gcc acc aag gct         96
Leu Leu Trp Val Pro Val Gly Gly Glu Val Val Asn Ala Thr Lys Ala           
            20                  25                  30                    

gtg atc acc ttg cag cct cca tgg gtc agt att ttc cag aag gaa aat        144
Val Ile Thr Leu Gln Pro Pro Trp Val Ser Ile Phe Gln Lys Glu Asn           
        35                  40                  45                        

gtc act tta tgg tgt gag ggg cct cac ctg cct gga gac agt tcc aca        192
Val Thr Leu Trp Cys Glu Gly Pro His Leu Pro Gly Asp Ser Ser Thr           
    50                  55                  60                            

caa tgg ttt atc aac gga aca gcc gtt cag atc tcc acg cct agt tat        240
Gln Trp Phe Ile Asn Gly Thr Ala Val Gln Ile Ser Thr Pro Ser Tyr           
65                  70                  75                  80            

agc atc cca gag gcc agt ttt cag gac agt ggc gaa tac agg tgt cag        288
Ser Ile Pro Glu Ala Ser Phe Gln Asp Ser Gly Glu Tyr Arg Cys Gln           
                85                  90                  95                

ata ggt tcc tca atg cca agt gac cct gtg cag ttg caa atc cac aat        336
Ile Gly Ser Ser Met Pro Ser Asp Pro Val Gln Leu Gln Ile His Asn           
            100                 105                 110                   

gat tgg ctg cta ctc cag gcc tcc cgc aga gtc ctc aca gaa gga gaa        384
Asp Trp Leu Leu Leu Gln Ala Ser Arg Arg Val Leu Thr Glu Gly Glu           
        115                 120                 125                       

ccc ctg gcc ttg agg tgt cac gga tgg aag aat aaa ctg gtg tac aat        432
Pro Leu Ala Leu Arg Cys His Gly Trp Lys Asn Lys Leu Val Tyr Asn           
    130                 135                 140                           

gtg gtt ttc tat aga aat gga aaa tcc ttt cag ttt tct tca gat tcg        480
Val Val Phe Tyr Arg Asn Gly Lys Ser Phe Gln Phe Ser Ser Asp Ser           
145                 150                 155                 160           

gag gtc gcc att ctg aaa acc aac ctg agt cac agc ggc atc tac cac        528
Glu Val Ala Ile Leu Lys Thr Asn Leu Ser His Ser Gly Ile Tyr His           
                165                 170                 175               

tgc tca ggc acg gga aga cac cgc tac aca tct gca gga gtg tcc atc        576
Cys Ser Gly Thr Gly Arg His Arg Tyr Thr Ser Ala Gly Val Ser Ile           
            180                 185                 190                   

acg gtg aaa gag ctg ttt acc acg cca gtg ctg aga gca tcc gtg tca        624
Thr Val Lys Glu Leu Phe Thr Thr Pro Val Leu Arg Ala Ser Val Ser           
        195                 200                 205                       

tct ccc ttc ccg gag ggg agt ctg gtc acc ctg aac tgt gag acg aat        672
Ser Pro Phe Pro Glu Gly Ser Leu Val Thr Leu Asn Cys Glu Thr Asn           
    210                 215                 220                           

ttg ctc ctg cag aga ccc ggc tta cag ctt cac ttc tcc ttc tac gtg        720
Leu Leu Leu Gln Arg Pro Gly Leu Gln Leu His Phe Ser Phe Tyr Val           
225                 230                 235                 240           

ggc agc aag atc ctg gag tac agg aac aca tcc tca gag tac cat ata        768
Gly Ser Lys Ile Leu Glu Tyr Arg Asn Thr Ser Ser Glu Tyr His Ile           
                245                 250                 255               

gca agg gcg gaa aga gaa gat gct gga ttc tac tgg tgt gag gta gcc        816
Ala Arg Ala Glu Arg Glu Asp Ala Gly Phe Tyr Trp Cys Glu Val Ala           
            260                 265                 270                   

acg gag gac agc agt gtc ctt aag cgc agc cct gag ttg gag gag cgc        864
Thr Glu Asp Ser Ser Val Leu Lys Arg Ser Pro Glu Leu Glu Glu Arg           
        275                 280                 285                       

aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg gca gga        912
Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly           
    290                 295                 300                           

ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg atc        960
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile           
305                 310                 315                 320           

tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac gaa       1008
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu           
                325                 330                 335               

gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc atg gag gtg cat       1056
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val His           
            340                 345                 350                   

aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc cgt       1104
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg           
        355                 360                 365                       

gtg gtc agc gtc ctc acc gtc gtg cac cag gac tgg ctg aac ggc aag       1152
Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys           
    370                 375                 380                           

gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc gag       1200
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu           
385                 390                 395                 400           

aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg tac       1248
Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr           
                405                 410                 415               

acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc ctg       1296
Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu           
            420                 425                 430                   

acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg       1344
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp           
        435                 440                 445                       

gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc atg       1392
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met           
    450                 455                 460                           

ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg gac       1440
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp           
465                 470                 475                 480           

aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg cat       1488
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His           
                485                 490                 495               

gag gct ctg cac aac cac tac aca cag aag agc ctc tcc ctg tct ccg       1536
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro           
            500                 505                 510                   

gag ctg caa ctg gag gag agc tgt gcg gag gcg cag gac ggg gag ctg       1584
Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu Leu           
        515                 520                 525                       

gac ggg ctg tgg acg acc atc acc atc ttc atc aca ctc ttc ctg cta       1632
Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu Leu           
    530                 535                 540                           

agc gtg tgc tac agt gcc acc atc acc ttc ttc aag gtg aag tgg atc       1680
Ser Val Cys Tyr Ser Ala Thr Ile Thr Phe Phe Lys Val Lys Trp Ile           
545                 550                 555                 560           

ttc tcc tca gtg gtg gac ctg aag cag acc atc gtc ccc gac tac agg       1728
Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp Tyr Arg           
                565                 570                 575               

aac atg atc agg cag ggg gcc tag                                       1752
Asn Met Ile Arg Gln Gly Ala                                               
            580                                                           


<210>  23
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chimeric fusion protein construct comprising Fc-gammaRIII and 
       membrane Ig


<220>
<221>  exon
<222>  (1)..(1512)

<400>  23
atg act ttg gac acc cag atg ttt cag aat gca cac tct gga agc caa         48
Met Thr Leu Asp Thr Gln Met Phe Gln Asn Ala His Ser Gly Ser Gln           
1               5                   10                  15                

tgg cta ctt cca cca ctg aca att ctg ctg ctg ttt gct ttt gca gac         96
Trp Leu Leu Pro Pro Leu Thr Ile Leu Leu Leu Phe Ala Phe Ala Asp           
            20                  25                  30                    

agg cag agt gca gct ctt ccg aag gct gtg gtg aaa ctg gac ccc cca        144
Arg Gln Ser Ala Ala Leu Pro Lys Ala Val Val Lys Leu Asp Pro Pro           
        35                  40                  45                        

tgg atc cag gtg ctc aag gaa gac atg gtg aca ctg atg tgc gaa ggg        192
Trp Ile Gln Val Leu Lys Glu Asp Met Val Thr Leu Met Cys Glu Gly           
    50                  55                  60                            

acc cac aac cct ggg aac tct tct act cag tgg ttc cac aac tgg agt        240
Thr His Asn Pro Gly Asn Ser Ser Thr Gln Trp Phe His Asn Trp Ser           
65                  70                  75                  80            

tcc atc cgg agc cag gtc caa tcc agc tac acg ttt aag gcc aca gtc        288
Ser Ile Arg Ser Gln Val Gln Ser Ser Tyr Thr Phe Lys Ala Thr Val           
                85                  90                  95                

aat gac agt gga gaa tat cgg tgt caa atg gag cag acc cgc ctc agc        336
Asn Asp Ser Gly Glu Tyr Arg Cys Gln Met Glu Gln Thr Arg Leu Ser           
            100                 105                 110                   

gac cct gta gat ctg gga gtg att tct gac tgg ctg ctg ctc cag acc        384
Asp Pro Val Asp Leu Gly Val Ile Ser Asp Trp Leu Leu Leu Gln Thr           
        115                 120                 125                       

cct cag cgg gtg ttt ctg gaa ggg gaa acc atc acg cta agg tgc cct        432
Pro Gln Arg Val Phe Leu Glu Gly Glu Thr Ile Thr Leu Arg Cys Pro           
    130                 135                 140                           

agc tgg agg aac aaa cta ctg aac agg atc tcg ttc ttc cat aat gaa        480
Ser Trp Arg Asn Lys Leu Leu Asn Arg Ile Ser Phe Phe His Asn Glu           
145                 150                 155                 160           

aaa tcc gtg agg tat cat cac tac aaa agt aat ttc tct atc cca aaa        528
Lys Ser Val Arg Tyr His His Tyr Lys Ser Asn Phe Ser Ile Pro Lys           
                165                 170                 175               

gcc aac cac agt cac agt ggg gac tac tac tgc aaa gga agt cta gga        576
Ala Asn His Ser His Ser Gly Asp Tyr Tyr Cys Lys Gly Ser Leu Gly           
            180                 185                 190                   

agt aca cag cac cag tcc aag cct gtc acc atc act gtc caa gac gag        624
Ser Thr Gln His Gln Ser Lys Pro Val Thr Ile Thr Val Gln Asp Glu           
        195                 200                 205                       

cgc aaa tgt tgt gtc gag tgc cca ccg tgc cca gca cca cct gtg gca        672
Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala           
    210                 215                 220                           

gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc atg        720
Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met           
225                 230                 235                 240           

atc tcc cgg acc cct gag gtc acg tgc gtg gtg gtg gac gtg agc cac        768
Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His           
                245                 250                 255               

gaa gac ccc gag gtc cag ttc aac tgg tac gtg gac ggc atg gag gtg        816
Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Met Glu Val           
            260                 265                 270                   

cat aat gcc aag aca aag cca cgg gag gag cag ttc aac agc acg ttc        864
His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe           
        275                 280                 285                       

cgt gtg gtc agc gtc ctc acc gtc gtg cac cag gac tgg ctg aac ggc        912
Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly           
    290                 295                 300                           

aag gag tac aag tgc aag gtc tcc aac aaa ggc ctc cca gcc ccc atc        960
Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile           
305                 310                 315                 320           

gag aaa acc atc tcc aaa acc aaa ggg cag ccc cga gaa cca cag gtg       1008
Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val           
                325                 330                 335               

tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag gtc agc       1056
Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser           
            340                 345                 350                   

ctg acc tgc ctg gtc aaa ggc ttc tac ccc agc gac atc gcc gtg gag       1104
Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu           
        355                 360                 365                       

tgg gag agc aat ggg cag ccg gag aac aac tac aag acc aca cct ccc       1152
Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro           
    370                 375                 380                           

atg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc gtg       1200
Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val           
385                 390                 395                 400           

gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg atg       1248
Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met           
                405                 410                 415               

cat gag gct ctg cac aac cac tac aca cag aag agc ctc tcc ctg tct       1296
His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser           
            420                 425                 430                   

ccg gag ctg caa ctg gag gag agc tgt gcg gag gcg cag gac ggg gag       1344
Pro Glu Leu Gln Leu Glu Glu Ser Cys Ala Glu Ala Gln Asp Gly Glu           
        435                 440                 445                       

ctg gac ggg ctg tgg acg acc atc acc atc ttc atc aca ctc ttc ctg       1392
Leu Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Thr Leu Phe Leu           
    450                 455                 460                           

cta agc gtg tgc tac agt gcc acc atc acc ttc ttc aag gtg aag tgg       1440
Leu Ser Val Cys Tyr Ser Ala Thr Ile Thr Phe Phe Lys Val Lys Trp           
465                 470                 475                 480           

atc ttc tcc tca gtg gtg gac ctg aag cag acc atc gtc ccc gac tac       1488
Ile Phe Ser Ser Val Val Asp Leu Lys Gln Thr Ile Val Pro Asp Tyr           
                485                 490                 495               

agg aac atg atc agg cag ggg gcc tag                                   1515
Arg Asn Met Ile Arg Gln Gly Ala                                           
            500                                                           


<210>  24
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2A peptide sequence


<220>
<221>  exon
<222>  (1)..(63)

<400>  24
gga agc gga gct act aac ttc agc ctg ctg aag cag gcg gag acg gga         48
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Glu Thr Gly           
1               5                   10                  15                

gga gaa ccc tgg acc                                                     63
Gly Glu Pro Trp Thr                                                       
            20                                                            


<210>  25
<211>  261
<212>  DNA
<213>  Mus musculus


<220>
<221>  exon
<222>  (1)..(258)

<400>  25
atg atc tca gcc gtg atc ttg ttc ttg ctc ctt ttg gtg gaa caa gca         48
Met Ile Ser Ala Val Ile Leu Phe Leu Leu Leu Leu Val Glu Gln Ala           
1               5                   10                  15                

gcc gcc ctg gga gag ccg cag ctc tgc tat atc ctg gat gct gtc ctg         96
Ala Ala Leu Gly Glu Pro Gln Leu Cys Tyr Ile Leu Asp Ala Val Leu           
            20                  25                  30                    

ttt ttg tat ggt att gtc ctt acc cta ctc tac tgt cga ctc aag atc        144
Phe Leu Tyr Gly Ile Val Leu Thr Leu Leu Tyr Cys Arg Leu Lys Ile           
        35                  40                  45                        

cag gtc cga aag gca gct ata gcc agc cgt gag aaa gca gat gct gtc        192
Gln Val Arg Lys Ala Ala Ile Ala Ser Arg Glu Lys Ala Asp Ala Val           
    50                  55                  60                            

tac acg ggc ctg aac acc cgg agc cag gag aca tat gag act ctg aag        240
Tyr Thr Gly Leu Asn Thr Arg Ser Gln Glu Thr Tyr Glu Thr Leu Lys           
65                  70                  75                  80            

cat gag aaa cca ccc cag tag                                            261
His Glu Lys Pro Pro Gln                                                   
                85                                                        


