                         SEQUENCE LISTING

<110>  Bayer Pharma AG
 
<120>  Anti-CEACAM6 Antibodies and Uses Thereof

<130>  BHC 14 1 064

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1173, h16C3-hIgG1, Heavy Chain

<400>  1

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1173, h16C3-hIgG1, Light Chain

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Thr Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, VH

<400>  3

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, HCDR1

<400>  4

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, HCDR2

<400>  5

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, HCDR3

<400>  6

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, VL

<400>  7

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, LCDR1

<400>  8

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, LCDR2

<400>  9

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, LCDR3

<400>  10

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  11
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, Heavy Chain

<400>  11

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu 
    


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2971, 792.15H12C9, Light Chain

<400>  12

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120         


<210>  13
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, VH

<400>  13

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Cys Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, HCDR1

<400>  14

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, HCDR2

<400>  15

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, HCDR3

<400>  16

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, VL

<400>  17

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  18
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, LCDR1

<400>  18

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, LCDR2

<400>  19

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, LCDR3

<400>  20

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  21
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, Heavy Chain

<400>  21

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Cys Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu 
    


<210>  22
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3186, 792.11G2D10, Light Chain

<400>  22

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120         


<210>  23
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, VH

<400>  23

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  24
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, HCDR1

<400>  24

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  25
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, HCDR2

<400>  25

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, HCDR3

<400>  26

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  27
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, VL

<400>  27

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  28
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, LCDR1

<400>  28

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, LCDR2

<400>  29

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, LCDR3

<400>  30

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  31
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, Heavy Chain

<400>  31

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu 
    


<210>  32
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3187, 792.15C4F4, Light Chain

<400>  32

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser 
        115                 120         


<210>  33
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, VH

<400>  33

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, HCDR1

<400>  34

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  35
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, HCDR2

<400>  35

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, HCDR3

<400>  36

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  37
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, VL

<400>  37

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  38
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, LCDR1

<400>  38

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, LCDR2

<400>  39

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, LCDR3

<400>  40

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  41
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, VH

<400>  41
caggtcacac tgaaagagag cggccctggc atcctgcagc ccagccagac cctgagcctg       60

acctgcagct tcagcggctt cagcctgagc acctacggca tcggcgtggg ctggatcaga      120

cagcccagcg gcaaggacct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacaacaccg ccctgaagtc ccggctgacc atcagcaagg acaccagcaa caaccaggtg      240

ttcctgaaga tcgccagcgt ggacaccgcc gataccgcca cctactactg cgcccggatc      300

agcctgccct acttcgacta ctggggccag ggcaccaccc tgaccgtgtc ctca            354


<210>  42
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, VL

<400>  42
gacatcgtga tgacccagag ccagaaattc atgagcacca gcgtgggcga ccgggtgtcc       60

atcacatgca aggccagcca gaacgtgggc accgccgtgg cctggtatca gcagaagccc      120

ggccagagcc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccgac      180

agattcacag gcagcggcag cggcaccgac ttcaccctga ccatcagcaa catgcagagc      240

gaggacctgg ccgactactt ctgccagcag tacagcagct accccctgac cttcggagcc      300

ggcaccaagc tggaactgaa a                                                321


<210>  43
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, Heavy Chain

<400>  43

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Asp Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  44
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, Light Chain

<400>  44

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  45
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, Heavy Chain

<400>  45
caggtcacac tgaaagagag cggccctggc atcctgcagc ccagccagac cctgagcctg       60

acctgcagct tcagcggctt cagcctgagc acctacggca tcggcgtggg ctggatcaga      120

cagcccagcg gcaaggacct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacaacaccg ccctgaagtc ccggctgacc atcagcaagg acaccagcaa caaccaggtg      240

ttcctgaaga tcgccagcgt ggacaccgcc gataccgcca cctactactg cgcccggatc      300

agcctgccct acttcgacta ctggggccag ggcaccaccc tgaccgtgtc ctcagccagc      360

accaagggcc ccagcgtgtt ccctctggcc ccttgtagca gaagcaccag cgagtctaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagcaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gccccccttg tcctgcccct ccagtggctg gcccttccgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      780

gtggatgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca acagcacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaagg gcctgcctgc ccccatcgag aaaaccatca gcaagaccaa aggccagccc     1020

cgcgagcccc aggtgtacac actgcctcca agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1140

aacggccagc ccgagaacaa ctacaagacc acccccccca tgctggacag cgacggctca     1200

ttcttcctgt acagcaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1320

agccctggc                                                             1329


<210>  46
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3308, TPP-2971X1-hIgG2Kappa, Light Chain

<400>  46
gacatcgtga tgacccagag ccagaaattc atgagcacca gcgtgggcga ccgggtgtcc       60

atcacatgca aggccagcca gaacgtgggc accgccgtgg cctggtatca gcagaagccc      120

ggccagagcc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccgac      180

agattcacag gcagcggcag cggcaccgac ttcaccctga ccatcagcaa catgcagagc      240

gaggacctgg ccgactactt ctgccagcag tacagcagct accccctgac cttcggagcc      300

ggcaccaagc tggaactgaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  47
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, VH

<400>  47

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, HCDR1

<400>  48

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, HCDR2

<400>  49

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, HCDR3

<400>  50

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, VL

<400>  51

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, LCDR1

<400>  52

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, LCDR2

<400>  53

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, LCDR3

<400>  54

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  55
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, VH

<400>  55
caagtgaccc tgagagagtc cggccctgcc ctcgtgaagc ctacccagac cctgacactg       60

acctgcacct tctccggctt ctccctgtcc acctacggca tcggcgtggg ctggatcaga      120

cagcctcctg gcaaggccct ggaatggctg gctcacatct ggtggaacga caacaagtac      180

tactccacct ccctgaaaac ccggctgacc atctccaagg acacctccaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagaatc      300

tccctgccct acttcgacta ctggggccag ggcaccacac tgaccgtcag ctca            354


<210>  56
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, VL

<400>  56
gatatccagc tgacccagtc ccccagcttc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtgggc accgccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgccctct      180

agattctccg gctctggctc tggcaccgag tttaccctga ccatctccag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactcctcct accccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa g                                                321


<210>  57
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, Heavy Chain

<400>  57

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, Light Chain

<400>  58

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  59
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, Heavy Chain

<400>  59
caagtgaccc tgagagagtc cggccctgcc ctcgtgaagc ctacccagac cctgacactg       60

acctgcacct tctccggctt ctccctgtcc acctacggca tcggcgtggg ctggatcaga      120

cagcctcctg gcaaggccct ggaatggctg gctcacatct ggtggaacga caacaagtac      180

tactccacct ccctgaaaac ccggctgacc atctccaagg acacctccaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagaatc      300

tccctgccct acttcgacta ctggggccag ggcaccacac tgaccgtcag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  60
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3310, TPP-2971HU1-hIgG2Kappa, Light Chain

<400>  60
gatatccagc tgacccagtc ccccagcttc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtgggc accgccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgccctct      180

agattctccg gctctggctc tggcaccgag tttaccctga ccatctccag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactcctcct accccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gcggaccgtg gccgctccct ccgtgtttat cttcccaccc      360

tccgacgagc agctgaagtc cggcacagct tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  61
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, VH

<400>  61

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Cys Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, HCDR1

<400>  62

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  63
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, HCDR2

<400>  63

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, HCDR3

<400>  64

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, VL

<400>  65

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, LCDR1

<400>  66

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, LCDR2

<400>  67

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, LCDR3

<400>  68

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  69
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, VH

<400>  69
caggtcacac tgaaagagag cggccctggc atcctgcagc ccagccagac cctgagcctg       60

acctgcagct tcagcggctt cagcctgagc acctacggca tcggcgtggg ctgcatcaga      120

cagcccagcg gcaagggcct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacaacaccg ccctgaagtc ccggctgacc atcagcaagg acaccagcaa caaccaggtg      240

ttcctgaaga tcgccagcgt ggacaccgcc gataccgcca cctactactg cgcccggatc      300

agcctgccct acttcgacta ctggggccag ggcaccaccc tgaccgtgtc ctca            354


<210>  70
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, VL

<400>  70
gacatcgtga tgacccagag ccagaaattc atgagcacca gcgtgggcga ccgggtgtcc       60

atcacatgca aggccagcca gaacgtgggc accgccgtgg cctggtatca gcagaagccc      120

ggccagagcc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccgac      180

agattcacag gcagcggcag cggcaccgac ttcaccttca ccatcagcaa catgcagagc      240

gaggacctgg ccgactactt ctgccagcag tacagcagct accccctgac cttcggagcc      300

ggcaccaagc tggaactgaa a                                                321


<210>  71
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, Heavy Chain

<400>  71

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Cys Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  72
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, Light Chain

<400>  72

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  73
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, Heavy Chain

<400>  73
caggtcacac tgaaagagag cggccctggc atcctgcagc ccagccagac cctgagcctg       60

acctgcagct tcagcggctt cagcctgagc acctacggca tcggcgtggg ctgcatcaga      120

cagcccagcg gcaagggcct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacaacaccg ccctgaagtc ccggctgacc atcagcaagg acaccagcaa caaccaggtg      240

ttcctgaaga tcgccagcgt ggacaccgcc gataccgcca cctactactg cgcccggatc      300

agcctgccct acttcgacta ctggggccag ggcaccaccc tgaccgtgtc ctcagccagc      360

accaagggcc ccagcgtgtt ccctctggcc ccttgtagca gaagcaccag cgagtctaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagcaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gccccccttg tcctgcccct ccagtggctg gcccttccgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      780

gtggatgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca acagcacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaagg gcctgcctgc ccccatcgag aaaaccatca gcaagaccaa aggccagccc     1020

cgcgagcccc aggtgtacac actgcctcca agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1140

aacggccagc ccgagaacaa ctacaagacc acccccccca tgctggacag cgacggctca     1200

ttcttcctgt acagcaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1320

agccctggc                                                             1329


<210>  74
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3322, TPP-3186X1-hIgG2, Light Chain

<400>  74
gacatcgtga tgacccagag ccagaaattc atgagcacca gcgtgggcga ccgggtgtcc       60

atcacatgca aggccagcca gaacgtgggc accgccgtgg cctggtatca gcagaagccc      120

ggccagagcc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccgac      180

agattcacag gcagcggcag cggcaccgac ttcaccttca ccatcagcaa catgcagagc      240

gaggacctgg ccgactactt ctgccagcag tacagcagct accccctgac cttcggagcc      300

ggcaccaagc tggaactgaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  75
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, VH

<400>  75

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, HCDR1

<400>  76

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, HCDR2

<400>  77

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala Leu Lys Ser 
1               5                   10                  15      


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, HCDR3

<400>  78

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  79
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, VL

<400>  79

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, LCDR1

<400>  80

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, LCDR2

<400>  81

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, LCDR3

<400>  82

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  83
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, VH

<400>  83
caagtgaccc tgaaagagtc cggccctggc atcctgcagc cttcccagac cctgtccctg       60

acctgctcct tctccggctt ctccctgacc acctacggca tcggcgtggg ctggatcaga      120

cagccttctg gcaagggcct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacaacaccg ccctgaagtc ccggctgacc atctccaagg acacctccaa caaccaggtg      240

ttcctgaaga tcgcctccgt ggacaccgcc gataccgcca cctactactg cgcccggatc      300

tccctgccct acttcgacta ttggggccag ggcaccaccc tgaccgtcag ctca            354


<210>  84
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, VL

<400>  84
gacatcgtga tgacccagtc ccagaaattc atgtccacct ccgtgggcga ccgggtgtcc       60

atcacatgca aggcctctca gaacgtgggc accgccgtgg cctggtatca gcagaagcct      120

ggccagtccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgcccgat      180

agattcaccg gctctggctc tggcaccgac ttcaccctga ccatctccaa catgcagtcc      240

gaggacctgg ccgactactt ctgccagcag tacaacaact accccctgac cttcggcgct      300

ggcaccaagc tggaactgaa g                                                321


<210>  85
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, Heavy Chain

<400>  85

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Asn Thr Ala 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Ala Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  86
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, Light Chain

<400>  86

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  87
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, Heavy Chain

<400>  87
caagtgaccc tgaaagagtc cggccctggc atcctgcagc cttcccagac cctgtccctg       60

acctgctcct tctccggctt ctccctgacc acctacggca tcggcgtggg ctggatcaga      120

cagccttctg gcaagggcct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacaacaccg ccctgaagtc ccggctgacc atctccaagg acacctccaa caaccaggtg      240

ttcctgaaga tcgcctccgt ggacaccgcc gataccgcca cctactactg cgcccggatc      300

tccctgccct acttcgacta ttggggccag ggcaccaccc tgaccgtcag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  88
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3323, TPP-3187X1-hIgG2, Light Chain

<400>  88
gacatcgtga tgacccagtc ccagaaattc atgtccacct ccgtgggcga ccgggtgtcc       60

atcacatgca aggcctctca gaacgtgggc accgccgtgg cctggtatca gcagaagcct      120

ggccagtccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgcccgat      180

agattcaccg gctctggctc tggcaccgac ttcaccctga ccatctccaa catgcagtcc      240

gaggacctgg ccgactactt ctgccagcag tacaacaact accccctgac cttcggcgct      300

ggcaccaagc tggaactgaa gagaaccgtg gccgctccct ccgtgtttat cttcccaccc      360

tccgacgagc agctgaagtc cggcacagct tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc taccctgacc      540

ctgtccaagg ccgattacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  89
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3688, h16C3-hIgG2Kappa, Heavy Chain

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Ser Thr Tyr Ser Gly Asp Thr Lys Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Val Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Ser Gly Ser Arg Tyr Trp Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  90
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3688, h16C3-hIgG2Kappa, Light Chain

<400>  90

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Arg Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Ala Thr Gly Met Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Val Leu Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  91
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, VH

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Phe Ser Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Gly Tyr Ser Ser Pro Trp Tyr Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, HCDR1

<400>  92

Leu Tyr Gln Met His 
1               5   


<210>  93
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, HCDR2

<400>  93

Trp Ile Ser Phe Ser Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  94
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, HCDR3

<400>  94

Ala Thr Gly Tyr Ser Ser Pro Trp Tyr Leu Asp Pro 
1               5                   10          


<210>  95
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, VL

<400>  95

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Glu Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Trp Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gly Tyr Asp Asp Leu Ser Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  96
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, LCDR1

<400>  96

Gln Ala Ser His Glu Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, LCDR2

<400>  97

Asp Ala Tyr Trp Leu Lys Thr 
1               5           


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, LCDR3

<400>  98

Gln Gly Tyr Asp Asp Leu Ser Val Thr 
1               5                   


<210>  99
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, VH

<400>  99
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttcagc ctgtaccaga tgcactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtgtcctgg atctccttct ccggcggcaa taccggctac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagagccacc      300

ggctactcct ccccctggta tctggatcct tggggccagg gcacactcgt gaccgtcagc      360

tca                                                                    363


<210>  100
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, VL

<400>  100
gacatccaga tgacccagag cccttccagc ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc aggcctccca cgagatcgac aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgat gcctactggc tgaaaaccgg cgtgccctcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctgcagccc      240

gaggatatcg ccacctacta ttgtcagggc tacgacgacc tgtccgtgac ctttggcgga      300

ggcaccaagg tggacatcaa g                                                321


<210>  101
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, Heavy Chain

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Phe Ser Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Gly Tyr Ser Ser Pro Trp Tyr Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  102
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, Light Chain

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Glu Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Trp Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gly Tyr Asp Asp Leu Ser Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  103
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, Heavy Chain

<400>  103
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttcagc ctgtaccaga tgcactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtgtcctgg atctccttct ccggcggcaa taccggctac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagagccacc      300

ggctactcct ccccctggta tctggatcct tggggccagg gcacactcgt gaccgtcagc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctct      420

gagtctaccg ccgctctggg ctgcctggtg aaagactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct ttccagccgt gctgcagtcc      540

tccggcctgt actccctgtc ctccgtggtg acagtgccct cctccaactt cggcacccag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aggtggacaa gaccgtggaa      660

cggaagtgct gcgtggaatg cccaccctgt cctgctccac ctgtggctgg ccccagcgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggacgtgtc ccacgaggac cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa ctccaccttc      900

cgggtggtgt ccgtgctgac cgtggtgcat caggactggc tgaacggcaa agagtacaag      960

tgcaaggtct ccaacaaggg cctgcctgcc cccatcgaaa agaccatcag caagaccaag     1020

ggccagcccc gcgagcccca ggtgtacaca ctgcccccca gccgggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctggtgaaa ggcttctacc cctccgacat tgccgtggaa     1140

tgggagtcca acggacagcc tgagaacaac tacaagacca ccccccccat gctggactcc     1200

gacggctcat tcttcctgta ctccaagctg acagtggaca agtcccggtg gcagcagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctga gccccggc                                                   1338


<210>  104
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3705, 090E-M007-A09-Mat1-hIgG2-hIgG2Kappa, Light Chain

<400>  104
gacatccaga tgacccagag cccttccagc ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc aggcctccca cgagatcgac aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgat gcctactggc tgaaaaccgg cgtgccctcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctgcagccc      240

gaggatatcg ccacctacta ttgtcagggc tacgacgacc tgtccgtgac ctttggcgga      300

ggcaccaagg tggacatcaa gcggacagtg gccgctccct ccgtgtttat cttcccaccc      360

tccgacgagc agctgaagtc cggcacagct tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaagtg gataacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  105
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, VH

<400>  105

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Phe Ser Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Gly Tyr Ser Ser Pro Trp Tyr Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  106
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, HCDR1

<400>  106

Leu Tyr Gln Met His 
1               5   


<210>  107
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, HCDR2

<400>  107

Trp Ile Ser Phe Ser Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  108
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, HCDR3

<400>  108

Ala Thr Gly Tyr Ser Ser Pro Trp Tyr Leu Asp Pro 
1               5                   10          


<210>  109
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, VL

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Glu Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Trp Ser Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gly Tyr Asp Asp Leu Ser Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys 
            100                 105         


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, LCDR1

<400>  110

Gln Ala Ser His Glu Ile Asp Asn Tyr Leu Asn 
1               5                   10      


<210>  111
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, LCDR2

<400>  111

Asp Ala Tyr Trp Ser Lys Thr 
1               5           


<210>  112
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, LCDR3

<400>  112

Gln Gly Tyr Asp Asp Leu Ser Val Thr 
1               5                   


<210>  113
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, VH

<400>  113
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttcagc ctgtaccaga tgcactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtgtcctgg atctccttct ccggcggcaa taccggctac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagagccacc      300

ggctactcct ccccctggta tctggatcct tggggccagg gcacactcgt gaccgtcagc      360

tca                                                                    363


<210>  114
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, VL

<400>  114
gacatccaga tgacccagag cccttccagc ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc aggcctccca cgagatcgac aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgac gcctactggt ccaagaccgg cgtgccctcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctgcagccc      240

gaggatatcg ccacctacta ttgtcagggc tacgacgacc tgtccgtgac ctttggcgga      300

ggcaccaagg tggacatcaa g                                                321


<210>  115
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, Heavy Chain

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Leu Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Trp Ile Ser Phe Ser Gly Gly Asn Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Thr Gly Tyr Ser Ser Pro Trp Tyr Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  116
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, Light Chain

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Glu Ile Asp Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Tyr Trp Ser Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gly Tyr Asp Asp Leu Ser Val 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  117
<211>  1338
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, Heavy Chain

<400>  117
gaagtgcagc tggtggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcttgtgccg cctccggctt caccttcagc ctgtaccaga tgcactgggt gcgacaggcc      120

cctggcaagg gactggaatg ggtgtcctgg atctccttct ccggcggcaa taccggctac      180

gccgactccg tgaagggccg gttcaccatc tcccgggaca actccaagaa caccctgtac      240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgtgc tagagccacc      300

ggctactcct ccccctggta tctggatcct tggggccagg gcacactcgt gaccgtcagc      360

tcagcttcca ccaagggccc ctccgtgttc cctctggccc cttgctcccg gtccacctct      420

gagtctaccg ccgctctggg ctgcctggtg aaagactact tccccgagcc cgtgaccgtg      480

tcctggaact ctggcgccct gacctccggc gtgcacacct ttccagccgt gctgcagtcc      540

tccggcctgt actccctgtc ctccgtggtg acagtgccct cctccaactt cggcacccag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aggtggacaa gaccgtggaa      660

cggaagtgct gcgtggaatg cccaccctgt cctgctccac ctgtggctgg ccccagcgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatct cccggacccc cgaagtgacc      780

tgcgtggtgg tggacgtgtc ccacgaggac cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagttcaa ctccaccttc      900

cgggtggtgt ccgtgctgac cgtggtgcat caggactggc tgaacggcaa agagtacaag      960

tgcaaggtct ccaacaaggg cctgcctgcc cccatcgaaa agaccatcag caagaccaag     1020

ggccagcccc gcgagcccca ggtgtacaca ctgcccccca gccgggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctggtgaaa ggcttctacc cctccgacat tgccgtggaa     1140

tgggagtcca acggacagcc tgagaacaac tacaagacca ccccccccat gctggactcc     1200

gacggctcat tcttcctgta ctccaagctg acagtggaca agtcccggtg gcagcagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctga gccccggc                                                   1338


<210>  118
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3707, 090E-M007-A09-Mat2-hIgG2-hIgG2Kappa, Light Chain

<400>  118
gacatccaga tgacccagag cccttccagc ctgtccgcct ctgtgggcga cagagtgacc       60

atcacctgtc aggcctccca cgagatcgac aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgac gcctactggt ccaagaccgg cgtgccctcc      180

agattctccg gctctggctc tggcaccgac tttaccctga ccatctccag cctgcagccc      240

gaggatatcg ccacctacta ttgtcagggc tacgacgacc tgtccgtgac ctttggcgga      300

ggcaccaagg tggacatcaa gcggacagtg gccgctccct ccgtgtttat cttcccaccc      360

tccgacgagc agctgaagtc cggcacagct tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaagtg gataacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  119
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, VH

<400>  119

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  120
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, HCDR1

<400>  120

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  121
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, HCDR2

<400>  121

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, HCDR3

<400>  122

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  123
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, VL

<400>  123

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, LCDR1

<400>  124

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, LCDR2

<400>  125

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  126
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, LCDR3

<400>  126

Gln Gln Tyr Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  127
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, VH

<400>  127
caagtgaccc tgagagagtc cggccctgcc ctcgtgaagc ctacccagac cctgacactg       60

acctgcacct tctccggctt ctccctgtcc acctacggca tcggcgtggg ctggatcaga      120

cagcctcctg gcaaggccct ggaatggctg gctcacatct ggtggaacga caacaagtac      180

tactccacct ccctgaaaac ccggctgacc atctccaagg acacctccaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagaatc      300

tccctgccct acttcgacta ctggggccag ggcacactcg tgaccgtcag ctca            354


<210>  128
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, VL

<400>  128
gatatccagc tgacccagtc ccccagcttc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtgggc accgccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgccctct      180

agattctccg gctctggctc tggcaccgag tttaccctga ccatctccag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactcctcct accccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa g                                                321


<210>  129
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, Heavy Chain

<400>  129

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  130
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, Light Chain

<400>  130

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  131
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, Heavy Chain

<400>  131
caagtgaccc tgagagagtc cggccctgcc ctcgtgaagc ctacccagac cctgacactg       60

acctgcacct tctccggctt ctccctgtcc acctacggca tcggcgtggg ctggatcaga      120

cagcctcctg gcaaggccct ggaatggctg gctcacatct ggtggaacga caacaagtac      180

tactccacct ccctgaaaac ccggctgacc atctccaagg acacctccaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagaatc      300

tccctgccct acttcgacta ctggggccag ggcacactcg tgaccgtcag ctcagcttcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc tgagtctacc      420

gccgctctgg gctgcctggt gaaagactac ttccccgagc ccgtgaccgt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc tttccagccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtggt gacagtgccc tcctccaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gcccaccctg tcctgctcca cctgtggctg gccccagcgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc tcccggaccc ccgaagtgac ctgcgtggtg      780

gtggacgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca actccacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtc      960

tccaacaagg gcctgcctgc ccccatcgaa aagaccatca gcaagaccaa gggccagccc     1020

cgcgagcccc aggtgtacac actgcccccc agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctggtgaa aggcttctac ccctccgaca ttgccgtgga atgggagtcc     1140

aacggacagc ctgagaacaa ctacaagacc acccccccca tgctggactc cgacggctca     1200

ttcttcctgt actccaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtccctg     1320

agccccggc                                                             1329


<210>  132
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3714, TPP-2971HU2-hIgG2Kappa, Light Chain

<400>  132
gatatccagc tgacccagtc ccccagcttc ctgtctgcct ctgtgggcga cagagtgacc       60

atcacatgca aggcctccca gaacgtgggc accgccgtgg cttggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctactcc gcctccaacc ggtacaccgg cgtgccctct      180

agattctccg gctctggctc tggcaccgag tttaccctga ccatctccag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tactcctcct accccctgac ctttggcgga      300

ggcaccaagg tggaaatcaa gcggaccgtg gccgctccct ccgtgtttat cttcccaccc      360

tccgacgagc agctgaagtc cggcacagct tccgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caactcccag      480

gaatccgtga ccgagcagga ctccaaggac agcacctact ccctgtcctc caccctgacc      540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gtctttcaac cggggcgagt gt                         642


<210>  133
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, VH

<400>  133

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, HCDR1

<400>  134

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  135
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, HCDR2

<400>  135

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  136
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, HCDR3

<400>  136

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  137
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, VL

<400>  137

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  138
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, LCDR1

<400>  138

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  139
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, LCDR2

<400>  139

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, LCDR3

<400>  140

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  141
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, VH

<400>  141
caagtgaccc tgagagagtc cggccctgcc ctcgtgaagc ctacccagac cctgacactg       60

acctgcacct tcagcggctt cagcctgacc acctacggca tcggcgtggg ctggatcaga      120

cagcctcctg gcaagggcct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagaatc      300

agcctgccct acttcgacta ctggggccag ggcaccctcg tgacagtgtc atca            354


<210>  142
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, VL

<400>  142
gatatccagc tgacccagag ccccagcttt ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca gaacgtgggc acagccgtgg cctggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgag ttcaccctga caatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accccctgac cttcggcgga      300

ggcaccaagg tggaaattaa a                                                321


<210>  143
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, Heavy Chain

<400>  143

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Thr Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  144
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, Light Chain

<400>  144

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  145
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, Heavy Chain

<400>  145
caagtgaccc tgagagagtc cggccctgcc ctcgtgaagc ctacccagac cctgacactg       60

acctgcacct tcagcggctt cagcctgacc acctacggca tcggcgtggg ctggatcaga      120

cagcctcctg gcaagggcct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgccagaatc      300

agcctgccct acttcgacta ctggggccag ggcaccctcg tgacagtgtc atcagccagc      360

accaagggcc ccagcgtgtt ccctctggcc ccttgtagca gaagcaccag cgagtctaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagcaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gccccccttg tcctgcccct ccagtggctg gcccttccgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      780

gtggatgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca acagcacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaagg gcctgcctgc ccccatcgag aaaaccatca gcaagaccaa aggccagccc     1020

cgcgagcccc aggtgtacac actgcctcca agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1140

aacggccagc ccgagaacaa ctacaagacc acccccccca tgctggacag cgacggctca     1200

ttcttcctgt acagcaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1320

agccctggc                                                             1329


<210>  146
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3820, 3187HU1-hIgG2Kappa, Light Chain

<400>  146
gatatccagc tgacccagag ccccagcttt ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca gaacgtgggc acagccgtgg cctggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgag ttcaccctga caatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accccctgac cttcggcgga      300

ggcaccaagg tggaaattaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  147
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, VH

<400>  147

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, HCDR1

<400>  148

Thr Tyr Gly Ile Gly Val Gly 
1               5           


<210>  149
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, HCDR2

<400>  149

His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  150
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, HCDR3

<400>  150

Ile Ser Leu Pro Tyr Phe Asp Tyr 
1               5               


<210>  151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, VL

<400>  151

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  152
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, LCDR1

<400>  152

Lys Ala Ser Gln Asn Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  153
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, LCDR2

<400>  153

Ser Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, LCDR3

<400>  154

Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
1               5                   


<210>  155
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, VH

<400>  155
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc acctacggca tcggcgtggg ctggatcaga      120

cagccccctg gcaaggccct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgcccggatc      300

agcctgccct acttcgacta ctggggccag ggcaccctgg tgaccgtgtc ctca            354


<210>  156
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, VL

<400>  156
gatatccagc tgacccagag ccccagcttt ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca gaacgtgggc acagccgtgg cctggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgag ttcaccctga caatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accccctgac cttcggcgga      300

ggcaccaagg tggaaattaa a                                                321


<210>  157
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, Heavy Chain

<400>  157

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440             


<210>  158
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, Light Chain

<400>  158

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  159
<211>  1329
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, Heavy Chain

<400>  159
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc acctacggca tcggcgtggg ctggatcaga      120

cagccccctg gcaaggccct ggaatggctg gcccacatct ggtggaacga caacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgcccggatc      300

agcctgccct acttcgacta ctggggccag ggcaccctgg tgaccgtgtc ctcagccagc      360

accaagggcc ccagcgtgtt ccctctggcc ccttgtagca gaagcaccag cgagtctaca      420

gccgccctgg gctgcctcgt gaaggactac tttcccgagc ccgtgaccgt gtcctggaac      480

tctggcgctc tgacaagcgg cgtgcacacc tttccagccg tgctgcagag cagcggcctg      540

tactctctga gcagcgtcgt gacagtgccc agcagcaact tcggcaccca gacctacacc      600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga acggaagtgc      660

tgcgtggaat gccccccttg tcctgcccct ccagtggctg gcccttccgt gttcctgttc      720

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg      780

gtggatgtgt cccacgagga ccccgaggtg cagttcaatt ggtacgtgga cggcgtggaa      840

gtgcacaacg ccaagaccaa gcccagagag gaacagttca acagcacctt ccgggtggtg      900

tccgtgctga ccgtggtgca tcaggactgg ctgaacggca aagagtacaa gtgcaaggtg      960

tccaacaagg gcctgcctgc ccccatcgag aaaaccatca gcaagaccaa aggccagccc     1020

cgcgagcccc aggtgtacac actgcctcca agccgggaag agatgaccaa gaaccaggtg     1080

tccctgacct gtctcgtgaa aggcttctac ccctccgata tcgccgtgga atgggagagc     1140

aacggccagc ccgagaacaa ctacaagacc acccccccca tgctggacag cgacggctca     1200

ttcttcctgt acagcaagct gacagtggac aagtcccggt ggcagcaggg caacgtgttc     1260

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     1320

agccctggc                                                             1329


<210>  160
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TPP-3821, 3187HU2-hIgG2Kappa, Light Chain

<400>  160
gatatccagc tgacccagag ccccagcttt ctgagcgcca gcgtgggcga cagagtgacc       60

atcacatgca aggccagcca gaacgtgggc acagccgtgg cctggtatca gcagaagcct      120

ggcaaggccc ccaagctgct gatctacagc gccagcaacc ggtacaccgg cgtgcccagc      180

agattttctg gcagcggctc cggcaccgag ttcaccctga caatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacaacaact accccctgac cttcggcgga      300

ggcaccaagg tggaaattaa acgaaccgtg gccgctccca gcgtgttcat cttcccacct      360

agcgacgagc agctgaagtc cggcacagcc tctgtcgtgt gcctgctgaa caacttctac      420

ccccgcgagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gaaagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac ccaccagggc      600

ctgtctagcc ccgtgaccaa gagcttcaac cggggcgagt gt                         642


<210>  161
<211>  532
<212>  PRT
<213>  Macaca mulatta (Rhesus monkey)

<400>  161

Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Leu Ile Gly Phe Asn 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Ala Lys Arg Leu Ile Val Ala Tyr 
        35                  40                  45              


Val Ile Glu Thr Gln Gln Thr Thr Pro Gly Pro Ala His Ser Gly Arg 
    50                  55                  60                  


Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Gly Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Arg Phe Trp Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Asp Phe Thr Cys Glu Pro Asp Ile His Ser Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Asp Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ala Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Leu Ser 
            180                 185                 190         


Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Val Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asn Ser Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Ser Trp Phe Val Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala Tyr Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Met Met Ile Thr Val Ser Gly Ile Glu 
        275                 280                 285             


Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
    290                 295                 300                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            500                 505                 510         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
        515                 520                 525             


His His His His 
    530         


<210>  162
<211>  292
<212>  PRT
<213>  Homo sapiens

<400>  162

Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly His His 
        275                 280                 285             


His His His His 
    290         


<210>  163
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  163

Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val Gly Tyr 
        35                  40                  45              


Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser Leu Ser 
    210                 215                 220                 


Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser Val Thr 
            260                 265                 270         


Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu Leu Ser 
        275                 280                 285             


Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr Val Thr 
    290                 295                 300                 


Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp Thr Gly 
305                 310                 315                 320 


Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser Ser Glu 
                325                 330                 335     


Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn Pro Val 
            340                 345                 350         


Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn Pro Ile 
        355                 360                 365             


Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr Asn Ala 
    370                 375                 380                 


Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly His His His His His His 
385                 390                 395                 400 


His His His His 
                


<210>  164
<211>  657
<212>  PRT
<213>  Homo sapiens

<400>  164

Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Ser 
                165                 170                 175     


Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser 
            180                 185                 190         


Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro Thr Ile 
        195                 200                 205             


Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Val Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser Asp Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala Glu Pro 
        275                 280                 285             


Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Glu 
    290                 295                 300                 


Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr Thr Tyr 
305                 310                 315                 320 


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
                325                 330                 335     


Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
            340                 345                 350         


Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser Val Asp 
        355                 360                 365             


His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Asp Pro 
    370                 375                 380                 


Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser 
385                 390                 395                 400 


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
                405                 410                 415     


Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile Ser Asn 
            420                 425                 430         


Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn Asn Ser 
        435                 440                 445             


Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala 
    450                 455                 460                 


Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu 
465                 470                 475                 480 


Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln Asn Thr 
                485                 490                 495     


Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg 
            500                 505                 510         


Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr 
        515                 520                 525             


Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser Val Ser 
    530                 535                 540                 


Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly Pro Asp 
545                 550                 555                 560 


Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn 
                565                 570                 575     


Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser 
            580                 585                 590         


Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu Phe Ile 
        595                 600                 605             


Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser 
    610                 615                 620                 


Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val 
625                 630                 635                 640 


Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala His His His His His 
                645                 650                 655     


His 
    


<210>  165
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1790, hCeacam6-WT-Fc-6xHis

<400>  165

Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly Ile Glu 
        275                 280                 285             


Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
    290                 295                 300                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            500                 505                 510         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
        515                 520                 525             


His His His His 
    530         


<210>  166
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1791, hCeacam6-Dom1-MacMul-Xa-Fc-His

<400>  166

Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Leu Ile Gly Phe Asn 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Ala Lys Arg Leu Ile Val Ala Tyr 
        35                  40                  45              


Val Ile Glu Thr Gln Gln Thr Thr Pro Gly Pro Ala His Ser Gly Arg 
    50                  55                  60                  


Glu Thr Val Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Gly Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Arg Phe Trp Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly Ile Glu 
        275                 280                 285             


Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
    290                 295                 300                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            500                 505                 510         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
        515                 520                 525             


His His His His 
    530         


<210>  167
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1792, hCeacam6-Dom2-MacMul-Xa-Fc-His

<400>  167

Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Asp Phe Thr Cys Glu Pro Asp Ile His Ser Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Asp Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ala Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Leu Ser 
            180                 185                 190         


Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe Ile Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly Ile Glu 
        275                 280                 285             


Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
    290                 295                 300                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            500                 505                 510         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
        515                 520                 525             


His His His His 
    530         


<210>  168
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1793, hCeacam6-Dom3-MacMul-Xa-Fc-His

<400>  168

Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn Arg Ser 
            180                 185                 190         


Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Val Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asn Ser Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Ser Trp Phe Val Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala Tyr Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Met Met Ile Thr Val Ser Gly Ile Glu 
        275                 280                 285             


Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
    290                 295                 300                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
305                 310                 315                 320 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                325                 330                 335     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            340                 345                 350         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        355                 360                 365             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    370                 375                 380                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
385                 390                 395                 400 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                405                 410                 415     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            420                 425                 430         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        435                 440                 445             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    450                 455                 460                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
465                 470                 475                 480 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                485                 490                 495     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            500                 505                 510         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
        515                 520                 525             


His His His His 
    530         


<210>  169
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-1794, hCeacam6-Dom1-8xHis (E.coli)

<400>  169

Met Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys 
1               5                   10                  15      


Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly Tyr 
            20                  25                  30          


Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly 
        35                  40                  45              


Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly 
    50                  55                  60                  


Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr 
65                  70                  75                  80  


Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu 
                85                  90                  95      


Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Gly Ser Gly 
            100                 105                 110         


Ser His His His His His His His His 
        115                 120     


<210>  170
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2443, cyno CEACAM-6-Xa-Fc-His

<400>  170

Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Thr Leu Gly Phe Asn 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Ala Lys Arg Leu Ile Val Ala Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Thr Thr Pro Gly Pro Ala His Ser Gly Arg 
    50                  55                  60                  


Glu Met Ile Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Ser Tyr Thr Leu Gln Ala Ile Lys Glu Asp Leu Val 
                85                  90                  95      


Thr Glu Glu Ala Thr Gly Arg Phe Trp Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Asp Phe Thr Cys Glu Pro Asp Ile His Ser Thr Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Asp Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn Asp Ala 
                165                 170                 175     


Gly Ala Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn Leu Ser 
            180                 185                 190         


Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Val Pro Thr Ile 
        195                 200                 205             


Ser Pro Ser Asn Ser Asn Tyr Arg Pro Gly Glu Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Ser Trp Phe Val Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn Ile Thr 
                245                 250                 255     


Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala Tyr Asn Ser Ala Thr 
            260                 265                 270         


Gly Leu Asn Arg Thr Thr Val Met Met Ile Thr Val Ser Gly Ser Ile 
        275                 280                 285             


Glu Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His 
    290                 295                 300                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
305                 310                 315                 320 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                325                 330                 335     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            340                 345                 350         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        355                 360                 365             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    370                 375                 380                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
385                 390                 395                 400 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                405                 410                 415     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            420                 425                 430         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        435                 440                 445             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    450                 455                 460                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
465                 470                 475                 480 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                485                 490                 495     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            500                 505                 510         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His 
        515                 520                 525             


His His His His His 
    530             


<210>  171
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-2452, cynomolgus Ceacam6-Dom1-Xa-Fc-His

<400>  171

Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Thr Leu Gly Phe Asn 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Ala Lys Arg Leu Ile Val Ala Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Thr Thr Pro Gly Pro Ala His Ser Gly Arg 
    50                  55                  60                  


Glu Met Ile Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Ser Tyr Thr Leu Gln Ala Ile Lys Glu Asp Leu Val 
                85                  90                  95      


Thr Glu Glu Ala Thr Gly Arg Phe Trp Val Tyr Pro Glu Leu Ile Glu 
            100                 105                 110         


Gly Arg Asp Met Asp Thr Gly Pro Lys Ser Cys Asp Lys Thr His Thr 
        115                 120                 125             


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
    130                 135                 140                 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
145                 150                 155                 160 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
                165                 170                 175     


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
            180                 185                 190         


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
        195                 200                 205             


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
    210                 215                 220                 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
225                 230                 235                 240 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
                245                 250                 255     


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
            260                 265                 270         


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
        275                 280                 285             


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
    290                 295                 300                 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
305                 310                 315                 320 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
                325                 330                 335     


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His 
            340                 345                 350         


His His His His 
        355     


<210>  172
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  172

Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val Thr Gln 
65                  70                  75                  80  


Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn Ala Pro 
            100                 105                 110         


Gly Leu Pro Val Gly Ala Val Ala Gly His His His His His His 
        115                 120                 125         


<210>  173
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Gly His Leu Ser Ala Pro Leu His Arg Val Arg Val Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Thr Glu Ser Met Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Gln Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Val 
65                  70                  75                  80  


Gly Tyr Ala Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Asn Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Ile Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Thr Tyr Gly Pro Asp Thr Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr Arg Pro Gly Ala Asn Leu Ser 
                245                 250                 255     


Leu Ser Cys Tyr Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Leu 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys His Ala Asn Asn Ser 
    290                 295                 300                 


Val Thr Gly Cys Asn Arg Thr Thr Val Lys Thr Ile Ile Val Thr Glu 
305                 310                 315                 320 


Leu Ser Pro Val Val Ala Lys Pro Gln Ile Lys Ala Ser Lys Thr Thr 
                325                 330                 335     


Val Thr Gly Asp Lys Asp Ser Val Asn Leu Thr Cys Ser Thr Asn Asp 
            340                 345                 350         


Thr Gly Ile Ser Ile Arg Trp Phe Phe Lys Asn Gln Ser Leu Pro Ser 
        355                 360                 365             


Ser Glu Arg Met Lys Leu Ser Gln Gly Asn Thr Thr Leu Ser Ile Asn 
    370                 375                 380                 


Pro Val Lys Arg Glu Asp Ala Gly Thr Tyr Trp Cys Glu Val Phe Asn 
385                 390                 395                 400 


Pro Ile Ser Lys Asn Gln Ser Asp Pro Ile Met Leu Asn Val Asn Tyr 
                405                 410                 415     


Asn Ala Leu Pro Gln Glu Asn Gly Leu Ser Pro Gly Ala Ile Ala Gly 
            420                 425                 430         


Ile Val Ile Gly Val Val Ala Leu Val Ala Leu Ile Ala Val Ala Leu 
        435                 440                 445             


Ala Cys Phe Leu His Phe Gly Lys Thr Gly Arg Ala Ser Asp Gln Arg 
    450                 455                 460                 


Asp Leu Thr Glu His Lys Pro Ser Val Ser Asn His Thr Gln Asp His 
465                 470                 475                 480 


Ser Asn Asp Pro Pro Asn Lys Met Asn Glu Val Thr Tyr Ser Thr Leu 
                485                 490                 495     


Asn Phe Glu Ala Gln Gln Pro Thr Gln Pro Thr Ser Ala Ser Pro Ser 
            500                 505                 510         


Leu Thr Ala Thr Glu Ile Ile Tyr Ser Glu Val Lys Lys Gln 
        515                 520                 525     


<210>  174
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Glu Ile Pro Met Gly Thr Gln Gly Cys Phe Ser Lys Ser Leu Leu 
1               5                   10                  15      


Leu Ser Ala Ser Ile Leu Val Leu Trp Met Leu Gln Gly Ser Gln Ala 
            20                  25                  30          


Ala Leu Tyr Ile Gln Lys Ile Pro Glu Gln Pro Gln Lys Asn Gln Asp 
        35                  40                  45              


Leu Leu Leu Ser Val Gln Gly Val Pro Asp Thr Phe Gln Asp Phe Asn 
    50                  55                  60                  


Trp Tyr Leu Gly Glu Glu Thr Tyr Gly Gly Thr Arg Leu Phe Thr Tyr 
65                  70                  75                  80  


Ile Pro Gly Ile Gln Arg Pro Gln Arg Asp Gly Ser Ala Met Gly Gln 
                85                  90                  95      


Arg Asp Ile Val Gly Phe Pro Asn Gly Ser Met Leu Leu Arg Arg Ala 
            100                 105                 110         


Gln Pro Thr Asp Ser Gly Thr Tyr Gln Val Ala Ile Thr Ile Asn Ser 
        115                 120                 125             


Glu Trp Thr Met Lys Ala Lys Thr Glu Val Gln Val Ala Glu Lys Asn 
    130                 135                 140                 


Lys Glu Leu Pro Ser Thr His Leu Pro Thr Asn Ala Gly Ile Leu Ala 
145                 150                 155                 160 


Ala Thr Ile Ile Gly Ser Leu Ala Ala Gly Ala Leu Leu Ile Ser Cys 
                165                 170                 175     


Ile Ala Tyr Leu Leu Val Thr Arg Asn Trp Arg Gly Gln Ser His Arg 
            180                 185                 190         


Leu Pro Ala Pro Arg Gly Gln Gly Ser Leu Ser Ile Leu Cys Ser Ala 
        195                 200                 205             


Val Ser Pro Val Pro Ser Val Thr Pro Ser Thr Trp Met Ala Thr Thr 
    210                 215                 220                 


Glu Lys Pro Glu Leu Gly Pro Ala His Asp Ala Gly Asp Asn Asn Ile 
225                 230                 235                 240 


Tyr Glu Val Met Pro Ser Pro Val Leu Leu Val Ser Pro Ile Ser Asp 
                245                 250                 255     


Thr Arg Ser Ile Asn Pro Ala Arg Pro Leu Pro Thr Pro Pro His Leu 
            260                 265                 270         


Gln Ala Glu Pro Glu Asn His Gln Tyr Gln Gln Asp Leu Leu Asn Pro 
        275                 280                 285             


Asp Pro Ala Pro Tyr Cys Gln Leu Val Pro Thr Ser 
    290                 295                 300 


<210>  175
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Gly Pro Pro Ser Ala Ser Pro His Arg Glu Cys Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Leu Asn Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Met Pro Leu Ser Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Ala Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Thr Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Ile Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Gln Glu Asn 
    130                 135                 140                 


Ala Pro Gly Leu Pro Val Gly Ala Val Ala Gly Ile Val Thr Gly Val 
145                 150                 155                 160 


Leu Val Gly Val Ala Leu Val Ala Ala Leu Val Cys Phe Leu Leu Leu 
                165                 170                 175     


Ala Lys Thr Gly Arg Thr Ser Ile Gln Arg Asp Leu Lys Glu Gln Gln 
            180                 185                 190         


Pro Gln Ala Leu Ala Pro Gly Arg Gly Pro Ser His Ser Ser Ala Phe 
        195                 200                 205             


Ser Met Ser Pro Leu Ser Thr Ala Gln Ala Pro Leu Pro Asn Pro Arg 
    210                 215                 220                 


Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys His Asp Thr Asn Ile 
225                 230                 235                 240 


Tyr Cys Arg Met Asp His Lys Ala Glu Val Ala Ser 
                245                 250         


<210>  176
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  177
<211>  344
<212>  PRT
<213>  Macaca fascicularis (Cynomolgus monkey)

<400>  177

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Ile Cys Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Ser Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Thr Leu Gly 
    50                  55                  60                  


Phe Asn Trp Tyr Lys Gly Glu Arg Val Asp Ala Lys Arg Leu Ile Val 
65                  70                  75                  80  


Ala Tyr Val Ile Gly Thr Gln Gln Thr Thr Pro Gly Pro Ala His Ser 
                85                  90                  95      


Gly Arg Glu Met Ile Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Ser Tyr Thr Leu Gln Ala Ile Lys Glu Asp 
        115                 120                 125             


Leu Val Thr Glu Glu Ala Thr Gly Arg Phe Trp Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Tyr Ile Thr Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Asp Phe Thr Cys Glu Pro Asp Ile His Ser Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asp Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ala Tyr Glu Cys Glu Ile Gln Asn Pro Val Ser Ala Asn 
    210                 215                 220                 


Leu Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Val Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asn Ser Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Thr Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala Tyr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Met Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Gly Leu Ser Ala Val Ala Thr Val Gly Ile Met Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  178
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Gly Pro Ile Ser Ala Pro Ser Cys Arg Trp Arg Ile Pro Trp Gln 
1               5                   10                  15      


Gly Leu Leu Leu Thr Ala Ser Leu Phe Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Gln Leu Thr Ile Glu Ala Val Pro Ser Asn Ala Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln Asp Pro Arg Gly 
    50                  55                  60                  


Tyr Asn Trp Tyr Lys Gly Glu Thr Val Asp Ala Asn Arg Arg Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Ser Asn Gln Gln Ile Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Asn Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Met Arg Asn Val 
            100                 105                 110         


Thr Arg Asn Asp Thr Gly Ser Tyr Thr Leu Gln Val Ile Lys Leu Asn 
        115                 120                 125             


Leu Met Ser Glu Glu Val Thr Gly Gln Phe Ser Val His Pro Glu Thr 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Leu Ser Val Thr Arg Asn 
        195                 200                 205             


Asp Val Gly Pro Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Phe Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Asp Thr Tyr Tyr His Ala Gly Val Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ser Gln Tyr Ser Trp Ser 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Tyr Thr Gln Lys Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Thr Lys Asn Ser Gly Ser Tyr Ala Cys His Thr Thr Asn Ser 
    290                 295                 300                 


Ala Thr Gly Arg Asn Arg Thr Thr Val Arg Met Ile Thr Val Ser Asp 
305                 310                 315                 320 


Ala Leu Val Gln Gly Ser Ser Pro Gly Leu Ser Ala Arg Ala Thr Val 
                325                 330                 335     


Ser Ile Met Ile Gly Val Leu Ala Arg Val Ala Leu Ile 
            340                 345                 


<210>  179
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  179

Met Gly Pro Pro Ser Ala Pro Pro Cys Arg Leu His Val Pro Trp Lys 
1               5                   10                  15      


Glu Val Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Ile Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val 
            100                 105                 110         


Thr Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Asn Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Val Gln Asn Thr Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Met Thr Leu Thr Leu Leu Ser Val Lys Arg Asn 
        195                 200                 205             


Asp Ala Gly Ser Tyr Glu Cys Glu Ile Gln Asn Pro Ala Ser Ala Asn 
    210                 215                 220                 


Arg Ser Asp Pro Val Thr Leu Asn Val Leu Tyr Gly Pro Asp Gly Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Ser Lys Ala Asn Tyr Arg Pro Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Ile Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Met Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Ala Thr Gly Leu Asn Arg Thr Thr Val Thr Met Ile Thr Val Ser Gly 
305                 310                 315                 320 


Ser Ala Pro Val Leu Ser Ala Val Ala Thr Val Gly Ile Thr Ile Gly 
                325                 330                 335     


Val Leu Ala Arg Val Ala Leu Ile 
            340                 


<210>  180
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Macaca fascicularis CEACAM6-Domain 1-His

<400>  180

Met Gln Leu Thr Ile Glu Ser Arg Pro Phe Asn Val Ala Glu Gly Lys 
1               5                   10                  15      


Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Thr Leu Gly Phe 
            20                  25                  30          


Asn Trp Tyr Lys Gly Glu Arg Val Asp Ala Lys Arg Leu Ile Val Ala 
        35                  40                  45              


Tyr Val Ile Gly Thr Gln Gln Thr Thr Pro Gly Pro Ala His Ser Gly 
    50                  55                  60                  


Arg Glu Met Ile Tyr Ser Asn Ala Ser Leu Leu Ile Gln Asn Val Thr 
65                  70                  75                  80  


Gln Asn Asp Thr Gly Ser Tyr Thr Leu Gln Ala Ile Lys Glu Asp Leu 
                85                  90                  95      


Val Thr Glu Glu Ala Thr Gly Arg Phe Trp Val Tyr Pro Glu Leu Gly 
            100                 105                 110         


Ser Gly Ser His His His His His His His His 
        115                 120             


<210>  181
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-5468 - Heavy Chain

<400>  181

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445         


<210>  182
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-5468 - Light Chain

<400>  182

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  183
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APP-1574 - Heavy Chain (Fab)

<400>  183

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Ile Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asn Asp Asn Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ile Ser Leu Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His 
225 


<210>  184
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APP-1574 - Light Chain (Fab)

<400>  184

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  185
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-8697, hCEACAM6-Domain 1-His - I30L

<400>  185

Met Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys 
1               5                   10                  15      


Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Leu Gly Tyr 
            20                  25                  30          


Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly 
        35                  40                  45              


Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly 
    50                  55                  60                  


Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr 
65                  70                  75                  80  


Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu 
                85                  90                  95      


Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Gly Ser Gly 
            100                 105                 110         


Ser His His His His His His His His 
        115                 120     


<210>  186
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TPP-8698, hCEACAM6-Domain 1-His - I30F

<400>  186

Met Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys 
1               5                   10                  15      


Glu Val Leu Leu Leu Ala His Asn Leu Pro Gln Asn Arg Phe Gly Tyr 
            20                  25                  30          


Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Ser Leu Ile Val Gly 
        35                  40                  45              


Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly 
    50                  55                  60                  


Arg Glu Thr Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Val Thr 
65                  70                  75                  80  


Gln Asn Asp Thr Gly Phe Tyr Thr Leu Gln Val Ile Lys Ser Asp Leu 
                85                  90                  95      


Val Asn Glu Glu Ala Thr Gly Gln Phe His Val Tyr Pro Gly Ser Gly 
            100                 105                 110         


Ser His His His His His His His His 
        115                 120     


