                         SEQUENCE LISTING

<110>  UNIVERSITE PARIS DESCARTES
       ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
       UNIVERSITE PARIS-SUD
       UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT GUSTAVE-ROUSSY
 
<120>  Isolated peptides and fragments thereof from fibrinogen for use 
       as drugs, particularly in skin inflammatory diseases

<130>  B370068D34732

<150>  EP 15305414.3
<151>  2015-03-20

<160>  47    

<170>  PatentIn version 3.5

<210>  1
<211>  491
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  sub-unit Bbeta of fibrinogen

<400>  1

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210>  2
<211>  35
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1

<400>  2

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp 
        35  


<210>  3
<211>  35
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.2

<400>  3

Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys 
1               5                   10                  15      


Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro Pro Ile Ser 
            20                  25                  30          


Gly Gly Gly 
        35  


<210>  4
<211>  36
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.3

<400>  4

Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu 
1               5                   10                  15      


Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu His Ala Asp Pro Asp Leu 
            20                  25                  30          


Gly Val Leu Cys 
        35      


<210>  5
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.4

<400>  5

Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly Val Asn Asp Asn 
1               5                   10                  15      


Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.5

<400>  6

Ala Pro Ser Leu Arg Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr 
1               5                   10                  15      


Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val 
            20                  25                  30  


<210>  7
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1.1

<400>  7

Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly Val Asn Asp 
1               5                   10                  15  


<210>  8
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1.2

<400>  8

Leu Leu Leu Cys Val 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1.3

<400>  9

Phe Leu Val Lys Ser 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1.4

<400>  10

Gln Gly Val Asn Asp 
1               5   


<210>  11
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1.5

<400>  11

Leu Leu Leu Cys Val Phe Leu Val 
1               5               


<210>  12
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1.1.6

<400>  12

Lys Ser Gln Gly Val Asn Asp 
1               5           


<210>  13
<211>  211
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1

<400>  13

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr 
65                  70                  75                  80  


Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu His 
                85                  90                  95      


Ala Asp Pro Asp Leu Gly Val Leu Cys Met Lys Arg Met Val Ser Trp 
            100                 105                 110         


Ser Phe His Lys Leu Lys Thr Met Lys His Leu Leu Leu Leu Leu Leu 
        115                 120                 125             


Cys Val Phe Leu Val Lys Ser Gln Gly Val Asn Asp Asn Glu Glu Gly 
    130                 135                 140                 


Phe Phe Ser Ala Arg Gly His Arg Pro Leu Asp Lys Lys Arg Glu Glu 
145                 150                 155                 160 


Ala Pro Ser Leu Arg Pro Ala Pro Pro Pro Ile Ser Gly Gly Gly Tyr 
                165                 170                 175     


Arg Ala Arg Pro Ala Lys Ala Ala Ala Thr Gln Lys Lys Val Glu Arg 
            180                 185                 190         


Lys Ala Pro Asp Ala Gly Gly Cys Leu His Ala Asp Pro Asp Leu Gly 
        195                 200                 205             


Val Leu Cys 
    210     


<210>  14
<211>  147
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg2

<400>  14

Asp Ala Gly Gly Cys Leu His Ala Asp Pro Asp Leu Gly Val Leu Cys 
1               5                   10                  15      


Pro Thr Gly Cys Gln Leu Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro 
            20                  25                  30          


Ile Arg Asn Ser Val Asp Glu Leu Asn Asn Asn Val Glu Ala Val Ser 
        35                  40                  45              


Gln Thr Ser Ser Ser Ser Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu 
    50                  55                  60                  


Trp Gln Lys Arg Gln Lys Gln Val Lys Asp Asn Glu Asn Val Val Asn 
65                  70                  75                  80  


Glu Tyr Ser Ser Glu Leu Glu Lys His Gln Leu Tyr Ile Asp Glu Thr 
                85                  90                  95      


Val Asn Ser Asn Ile Pro Thr Asn Leu Arg Val Leu Arg Ser Ile Leu 
            100                 105                 110         


Glu Asn Leu Arg Ser Lys Ile Gln Lys Leu Glu Ser Asp Val Ser Ala 
        115                 120                 125             


Gln Met Glu Tyr Cys Arg Thr Pro Cys Thr Val Ser Cys Asn Ile Pro 
    130                 135                 140                 


Val Val Ser 
145         


<210>  15
<211>  154
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg3

<400>  15

Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg Thr Pro 
1               5                   10                  15      


Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu Cys Glu 
            20                  25                  30          


Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu Ile Gln 
        35                  40                  45              


Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met Asn Thr 
    50                  55                  60                  


Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly Ser Val 
65                  70                  75                  80  


Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly Asn Val 
                85                  90                  95      


Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly Glu Tyr 
            100                 105                 110         


Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly Pro Thr 
        115                 120                 125             


Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val Lys Ala 
    130                 135                 140                 


His Tyr Gly Gly Phe Thr Val Gln Asn Glu 
145                 150                 


<210>  16
<211>  154
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg4

<400>  16

Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
1               5                   10                  15      


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
            20                  25                  30          


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
        35                  40                  45              


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
    50                  55                  60                  


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
65                  70                  75                  80  


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
                85                  90                  95      


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
            100                 105                 110         


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
        115                 120                 125             


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
    130                 135                 140                 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln 
145                 150                 


<210>  17
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  17
gcaggaattc tgatgaaaag gatggtttct tgg                                    33


<210>  18
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  18
ggccgctcga gtacacaaca cccccaggtc tgg                                    33


<210>  19
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  19
gcaggaattc tggatgctgg aggctgtctt cac                                    33


<210>  20
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  20
ggccgctcga ctagacacca caggaatatt gca                                    33


<210>  21
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  21
gcaggaattc tgaagttaga atctgatgtc tca                                    33


<210>  22
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  22
ggccgctcga gtttcattct gtacagtgaa tcc                                    33


<210>  23
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  23
gcaggaattc tgcccacaga acttttgata gaa                                    33


<210>  24
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  primer

<400>  24
ggccgctcga gtctgtggga agaagggcct gat                                    33


<210>  25
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  25

Ala Gly Ile Asp Lys 
1               5   


<210>  26
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  26

Ala Ala Ile Ala Gly Ala Leu Val Lys 
1               5                   


<210>  27
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  27

Thr Ala Glu Gln Leu Glu Lys 
1               5           


<210>  28
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  28

Ile Val Thr His Leu Val Arg 
1               5           


<210>  29
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  29

Ala Ala Ala Ala Val Asp Leu Gly Ile Lys 
1               5                   10  


<210>  30
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  30

Ser Leu Ala Val Gln Ile Ala Pro Arg 
1               5                   


<210>  31
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  31

Ala Ala Ile Glu His Ile Ile Gly Arg 
1               5                   


<210>  32
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  32

Glu Pro Leu Leu Ala Leu Asn Thr Ala Lys 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  33

Gln Ile Val Asp Val Ile Thr Ala Asp Lys 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  34

Gln Ile Val Asp Val Ile Thr Ala Asp Lys 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  35

Lys Ala Ala Ile Glu His Ile Ile Gly Arg 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  36

Glu Leu Pro Ala Leu Asp Asp Leu Val Lys 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  37

Glu Gly Val Leu Leu Ile Asn His His Lys 
1               5                   10  


<210>  38
<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  38

Ala Glu Ile Ala Ala Gln Ala Ala Leu Leu Val Gly Arg 
1               5                   10              


<210>  39
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  39

Ala Gly Phe Ser Ser Ala Asp Ala Val Ala Leu Ala Pro Arg 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  40

Asp Ala Val Val Ala Asn Leu Val Ala Ala Gly Val Asp Lys 
1               5                   10                  


<210>  41
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  41

Asp Ala Val Val Ala Asn Leu Val Ala Ala Gly Val Asp Lys Lys 
1               5                   10                  15  


<210>  42
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  42

Ala Gly Phe Ser Ser Ala Asp Ala Val Ala Leu Ala Pro Arg Ile Ala 
1               5                   10                  15      


Lys 
    


<210>  43
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  43

Ala Thr Leu Ala Ala Thr Ile Ile Pro Asn Ala Leu His Ser Ala Ala 
1               5                   10                  15      


Phe Lys 
        


<210>  44
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  44

Ala Thr Ala Val Ala Ile Ala Ala Thr Ala Leu Asn Pro Ala Leu Gly 
1               5                   10                  15      


Pro Ile Ala Lys 
            20  


<210>  45
<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  45

Ser Phe Asp Ala Ala Val Ala Thr Ala Ile Val Ser Ser Pro Ile Leu 
1               5                   10                  15      


Asn Ala Arg 
            


<210>  46
<211>  33
<212>  PRT
<213>  artificial

<220>
<223>  fragment of P.acnes Pfg protein

<400>  46

Ser Gly Gly His Ser Gln Gly Gly Ser Gly Thr His Tyr Ile His His 
1               5                   10                  15      


Gly Val Ala Pro Val Leu Thr His Ser Ser Asp Leu Pro Ser Thr Gly 
            20                  25                  30          


Phe 
    


<210>  47
<211>  106
<212>  PRT
<213>  artificial

<220>
<223>  fragment Fg1

<400>  47

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys 
            100                 105     


