                         SEQUENCE LISTING

<110>  The United States of America as Represented by the 
       Secretary, Department of Health and Human Services
       Connors, Mark
       Huang, Jinghe
       Kang, Byong
       Mascola, John
       Ishida, Elise
       Zheng, Anqi
       Zhou, Tongqing
       Kwong, Peter
 
<120>  NEUTRALIZING ANTIBODIES TO GP120 AND THEIR USE

<130>  4239-94622-03

<150>  US 62/136,228
<151>  2015-03-20

<150>  US 62/250,378
<151>  2015-11-03

<160>  115   

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  1

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  2
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  2

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  3
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  3

Arg Ala His Leu Val Gln Ser Gly Thr Ala Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Tyr Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Asp Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  4
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  4

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Arg Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Arg His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu Asp Phe Lys 
            100             


<210>  5
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Leu Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Ala Ser Ala 
        115                 120         


<210>  6
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  6

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  7
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  7

Ala His Ile Leu Phe 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  8

Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  9
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  9

Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala 
1               5                   10              


<210>  10
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  10

Gln Thr Ser Gln Gly Val Gly Ser Asp Leu His 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  11

His Thr Ser Ser Val Glu Asp 
1               5           


<210>  12
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  12

Gln Val Leu Gln Phe 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  13

Ala His Ile Leu Tyr 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  homo sapiens

<400>  14

Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  13
<212>  PRT
<213>  homo sapiens

<400>  15

Asp Arg Ser Tyr Asp Asp Ser Ser Trp Ala Leu Asp Ala 
1               5                   10              


<210>  16
<211>  11
<212>  PRT
<213>  homo sapiens

<400>  16

Gln Thr Ser Gln Gly Val Gly Arg Asp Leu His 
1               5                   10      


<210>  17
<211>  7
<212>  PRT
<213>  homo sapiens

<400>  17

His Ala Ser Ser Val Glu Asp 
1               5           


<210>  18
<211>  5
<212>  PRT
<213>  homo sapiens

<400>  18

Gln Val Leu Glu Ser 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is F or Y

<400>  19

Ala His Ile Leu Xaa 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is D or G

<400>  20

Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe Arg 
1               5                   10                  15      


Xaa 
    


<210>  21
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is G or D

<400>  21

Ala Arg Asp Arg Ser Tyr Xaa Asp Ser Ser Trp Ala Leu Asp Ala Trp 
1               5                   10                  15      


<210>  22
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is G or S

<400>  22

Gln Thr Ser Gln Gly Val Gly Xaa Asp Leu His 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is A or T

<400>  23

His Xaa Ser Ser Val Glu Asp 
1               5           


<210>  24
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is E or Q

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is S or F

<400>  24

Gln Val Leu Xaa Xaa Phe 
1               5       


<210>  25
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  25

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  26
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  26

Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro Ala Phe 
1               5                   10                  15      


Leu Leu Ile Pro Asp Thr 
            20          


<210>  27
<211>  236
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  27

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
225                 230                 235     


<210>  28
<211>  69
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  28

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys 
65                  


<210>  29
<211>  67
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  29

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg 
65          


<210>  30
<211>  112
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  30

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  31
<211>  84
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  31

Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro 
1               5                   10                  15      


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
            20                  25                  30          


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
        35                  40                  45              


Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly 
    50                  55                  60                  


Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Asn 
65                  70                  75                  80  


His Arg Asn Arg 
                


<210>  32
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  32

Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
1               5                   10                  15      


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
            20                  25                  30          


Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40  


<210>  33
<211>  42
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  33

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  34
<211>  47
<212>  PRT
<213>  artificial sequence

<220>
<223>  CAR sequence

<400>  34

Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
1               5                   10                  15      


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
            20                  25                  30          


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40                  45          


<210>  35
<211>  856
<212>  PRT
<213>  human immunodeficiency virus

<400>  35

Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      


Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          


Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              


Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  


Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  


Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      


Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         


Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             


Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 


Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 


Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     


Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         


Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             


Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 


Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 


Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     


Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         


Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             


Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 


Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 


Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     


Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         


Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             


Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 


Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 


Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     


Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         


Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             


Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 


Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 


Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     


Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         


Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             


Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 


Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 


Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     


Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         


Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             


Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 


His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 


Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     


Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         


Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             


Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 


Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 


Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     


Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         


Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             


His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 


Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 


Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     


Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         


Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             


Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     


<210>  36
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  36
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc       60

tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagacg tatatagaga gattgcgtac      240

atggacatca gaggccttaa acctgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tccgcg                                                                 366


<210>  37
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  37
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagagtcacc       60

atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg      120

gggagagccc ctaaactctt gatccaccat acctcttctg tggaagacgg tgtcccctca      180

agattcagcg gctctggatt tcacacatct tttaatctga ccatcagcga cctacaggct      240

gacgacattg ccacatatta ctgtcaagtt ttacaatttt tcggccgagg gagtcgactc      300

catattaaa                                                              309


<210>  38
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  38
cgagcgcacc tggtacaatc agggactgcg gtgaagagac cgggggcctc agtaagggtc       60

tcctgcgaga cttctggata cacctttacc gcccacatat tatactggtt ccgacaggcc      120

cccgggcgag ggcttgagtg ggtggggtgg atcaagccac aatacggtgc cgtgaacttt      180

gggggtggtt ttcggggcag ggtcacattg acgcgagaca tatatagaga tactgcatat      240

atggacatca gtggcctgag atttgacgac acggccgtct actattgtgc gagagaccgt      300

tcttatgacg actcttcttg ggccttagat gcctggggcc agggaacgac ggtcgtcgtc      360

tccgcg                                                                 366


<210>  39
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  39
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctgctgggga cagagtcacc       60

atcaattgcc agacgagtca gggtgttggc cgtgacctac attggtatca acacaaaccg      120

gggagagccc ctaaactcct gatccgccac gcctcttctg tggaggacgg tgtcccgtca      180

agattcagtg gcactggatt tcacacatct tttaatttga ccatcaacga cctgcagtct      240

gacgacattg ccacatatta ctgtcaggtg ttagaatctt tcggccgagg gagtcgactg      300

gattttaaa                                                              309


<210>  40
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  40
caggtgcagc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagggtc       60

tcctgccaga cttctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag ggcttgagtg ggtgggatgg atcaagccac aatacggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagaca tatatagaga gattgcatac      240

atggacatca gaggccttaa acttgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgcc      360

tccgcg                                                                 366


<210>  41
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  41
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagagtcacc       60

atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg      120

gggagagccc ctaaactctt gatccaccat gcctcttctg tggaggacgg tgtcccgtca      180

agattcagtg gctctggatt tcacacatct tttaatctga ccatcaacga cctacaggct      240

gacgacattg ccacatatta ctgtcaggtt ttacaatttt tcggccgagg gagtcgactc      300

catattaaa                                                              309


<210>  42
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Tyr Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  43
<211>  121
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Gly Gly Gly Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  44
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120         


<210>  45
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  45

Gln Val Arg Leu Ser Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Asp 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asn Cys 
            20                  25                  30          


Pro Ile Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Met Lys Pro Arg His Gly Ala Val Ser Tyr Ala Arg Gln Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Met Tyr Ser Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Pro Val Thr Val Ser Ser 
        115                 120         


<210>  46
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Thr Gln Met Lys Glu Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Val Thr Ser Gly Tyr Glu Phe Val Glu Ile 
            20                  25                  30          


Leu Ile Asn Trp Val Arg Gln Val Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met Asn Pro Arg Gly Gly Gly Val Asn Tyr Ala Arg Gln Phe 
    50                  55                  60                  


Gln Gly Lys Val Thr Met Thr Arg Asp Val Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Leu Thr Leu Ser Gly Leu Thr Ser Gly Asp Thr Ala Lys Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Ile Val Ser Pro 
        115                 120         


<210>  47
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  47

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Gly Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  48
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  48

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Ala Arg Pro Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  49
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  49

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Tyr Cys Thr Ala Arg Asp Tyr Tyr Asn Trp Ala Leu 
            100                 105                 110         


Asp Ala Trp Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120                 125 


<210>  50
<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  50

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Ser Cys Cys Gly Gly Arg Arg His Cys Asn Gly Ala 
            100                 105                 110         


Asp Cys Phe Asn Trp Ala Leu Asp Ala Trp Gly Gln Gly Thr Thr Val 
        115                 120                 125             


Val Val Ser Ala 
    130         


<210>  51
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  51

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Lys Phe Gly Ala Val Asn Tyr Ala His Ser Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  52
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  52

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Tyr Asp Gly Ser Ser Trp Arg Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  53
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  53

Ser Gln Arg Leu Val Gln Ser Gly Pro Gln Val Arg Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Thr Phe Asn Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  54
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  54

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Ser Phe Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  55
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  55

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Ile Thr Leu Thr Arg Asp Ile Tyr Arg Glu Thr Ala Phe 
65                  70                  75                  80  


Leu Asp Leu Thr Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  56
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  56

Arg Ala His Leu Val Gln Ser Gly Thr Ala Val Lys Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  57
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  57

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  58
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  58

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  59
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  59

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Arg His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  60
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  60

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ser 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  61
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  61

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu Asp Phe Lys 
            100             


<210>  62
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  62

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Arg Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  63
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  63

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  64
<211>  103
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant antibody sequence

<400>  64

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  65
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  65
ttgctacttg tgattgctcc atgt                                              24


<210>  66
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  66
tagagccctg gaagcatcca ggaag                                             25


<210>  67
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  67
ttgctacttg tgattgctcc atgt                                              24


<210>  68
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  68
caccttaggc atctcctatg gcaggaagaa g                                      31


<210>  69
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  69
gtctcgagat actgctccca ccc                                               23


<210>  70
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  70
caccatggca ggaagaag                                                     18


<210>  71
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  oligonucleotide primer

<400>  71
gtctcgagat actgctccca ccc                                               23


<210>  72
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic peptide

<400>  72

Ala Phe Ile Leu Met Tyr Trp Val 
1               5               


<210>  73
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Gly Gln Met Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Met Arg Ile Ser Cys Arg Ala Ser Gly Tyr Glu Phe Ile Asp Cys 
            20                  25                  30          


Thr Leu Asn Trp Ile Arg Leu Ala Pro Gly Lys Arg Pro Glu Trp Met 
        35                  40                  45              


Gly Trp Leu Lys Pro Arg Gly Gly Ala Val Asn Tyr Ala Arg Pro Leu 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Val Tyr Ser Asp Thr Ala Phe 
65                  70                  75                  80  


Leu Glu Leu Arg Ser Leu Thr Val Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Thr Arg Gly Lys Asn Cys Asp Tyr Asn Trp Asp Phe Glu His Trp Gly 
            100                 105                 110         


Arg Gly Thr Pro Val Ile Val Ser Ser 
        115                 120     


<210>  74
<211>  104
<212>  PRT
<213>  homo sapiens

<400>  74

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ala Ile Ile Ser Cys Arg Thr Ser Gln Tyr Gly Ser Leu Ala 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Val Ile Tyr Ser 
        35                  40                  45              


Gly Ser Thr Arg Ala Ala Gly Ile Pro Asp Arg Phe Ser Gly Ser Arg 
    50                  55                  60                  


Trp Gly Pro Asp Tyr Asn Leu Thr Ile Ser Asn Leu Glu Ser Gly Asp 
65                  70                  75                  80  


Phe Gly Val Tyr Tyr Cys Gln Gln Tyr Glu Phe Phe Gly Gln Gly Thr 
                85                  90                  95      


Lys Val Gln Val Asp Ile Lys Arg 
            100                 


<210>  75
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  75

Gln Arg Leu Val Gln Ser Gly Pro Gln Val Arg Lys Pro Gly Ser Ser 
1               5                   10                  15      


Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Thr Phe Asn Ala Tyr Ile 
            20                  25                  30          


Leu His Trp Phe Arg Gln Ala Pro Gly Arg Ser Phe Glu Trp Met Gly 
        35                  40                  45              


Trp Ile Lys Pro Lys Phe Gly Ala Val Asn Tyr Ala His Ser Phe Gln 
    50                  55                  60                  


Gly Arg Ile Thr Leu Thr Arg Asp Ile Tyr Arg Glu Thr Ala Phe Leu 
65                  70                  75                  80  


Asp Leu Thr Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Arg Leu Tyr Asp Gly Ser Ser Trp Arg Leu Asp Pro Trp Gly 
            100                 105                 110         


Gln Gly Thr Arg Val Val Val Ser Ser 
        115                 120     


<210>  76
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  76

Phe Ala Leu Met Thr Gln Ser Pro Ala Thr Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Arg Pro Pro Lys Ile Leu Ile 
        35                  40                  45              


His His Ala Ser Ala Arg Glu Glu Gly Val Pro Ser Arg Phe Gly Gly 
    50                  55                  60                  


Ser Gly Ser His Thr Ser Phe Ile Phe Thr Ile Asn Asp Leu Gln Leu 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Asp Ile Asn 
            100             


<210>  77
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  77

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Cys Gly Gly Asp Cys Tyr Asn Trp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  78
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  79
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  79

Arg Gly His Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Ile Leu His Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Lys Tyr Gly Ala Val Asn Tyr Ala His Ala Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Val Tyr Asp Asp Ser Ser Trp Gln Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Ile Val Ser Ser 
        115                 120         


<210>  80
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  80

Arg Gly His Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu His Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Lys Tyr Gly Ala Val Asn Tyr Ala His Ala Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Val Tyr Asp Asp Ser Ser Trp Gln Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Ile Val Ser 
        115                 120     


<210>  81
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  81

Arg Ala His Leu Val Gln Ser Gly Thr Ala Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Tyr Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Ser Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Asp Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  82
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  82

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Leu Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  83
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  83

Ser Gln Arg Leu Val Gln Ser Gly Pro Gln Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Glu Thr Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Ile Leu His Trp Phe Arg Gln Ala Pro Gly Arg Ser Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Lys Pro Lys Phe Gly Ala Val Asn Tyr Ala His Ser Phe 
    50                  55                  60                  


Gln Gly Arg Ile Thr Leu Thr Arg Asp Ile Tyr Arg Glu Ile Ala Phe 
65                  70                  75                  80  


Leu Asp Leu Thr Gly Leu Arg Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Tyr Asp Gly Ser Ser Trp Arg Leu Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Arg Val Ile Val Ser Ser 
        115                 120         


<210>  84
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  84

Tyr Ile Gln Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Val Gly Asn Asp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Glu Ala Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Glu Ile 
            100         


<210>  85
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  85

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Val Gly Asn Asp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Thr Leu Glu Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Gly Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Glu Ile 
            100         


<210>  86
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  86

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Thr Leu Glu Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Asp Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Glu Ile 
            100         


<210>  87
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  87

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu Asp Ile 
            100         


<210>  88
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  88

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Ser Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu Asp Ile 
            100         


<210>  89
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  89

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile 
            100         


<210>  90
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  90

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Arg Gly Arg Pro Pro Lys Ile Leu Ile 
        35                  40                  45              


His His Ala Ser Ala Arg Glu Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Asp Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Glu Ile 
            100         


<210>  91
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  91

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Arg Gly Arg Pro Pro Lys Ile Leu Ile 
        35                  40                  45              


His His Ala Ser Ala Arg Glu Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Asp Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Glu Ile 
            100         


<210>  92
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  92

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Arg Gly Arg Pro Pro Lys Ile Leu Ile 
        35                  40                  45              


His His Ala Ser Ala Arg Glu Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Asp Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Glu Ile 
            100         


<210>  93
<211>  102
<212>  PRT
<213>  homo sapiens

<400>  93

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Arg Gly Arg Pro Pro Lys Ile Leu Ile 
        35                  40                  45              


His His Ala Ser Ala Arg Glu Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Thr Phe Thr Ile Asn Asp Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Val Ala Thr Tyr Tyr Cys Gln Val Leu Glu Ser Phe Gly Gln 
                85                  90                  95      


Gly Thr Arg Leu Asp Ile 
            100         


<210>  94
<211>  452
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody heavy chain

<400>  94

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  95
<211>  1356
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody heavy chain

<400>  95
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc       60

tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagacg tatatagaga gattgcgtac      240

atggacatca gaggccttaa acctgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tccgcggcgt cgaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1356


<210>  96
<211>  210
<212>  PRT
<213>  homo sapiens

<400>  96

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Thr Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp 
    130                 135                 140                 


Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr 
145                 150                 155                 160 


Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr 
                165                 170                 175     


Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val 
            180                 185                 190         


Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly 
        195                 200                 205             


Glu Cys 
    210 


<210>  97
<211>  630
<212>  DNA
<213>  homo sapiens

<400>  97
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagagtcacc       60

atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg      120

gggagagccc ctaaactctt gatccaccat acctcttctg tggaagacgg tgtcccctca      180

agattcagcg gctctggatt tcacacatct tttaatctga ccatcagcga cctacaggct      240

gacgacattg ccacatatta ctgtcaagtt ttacaatttt tcggccgagg gagtcgactc      300

catattaaac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag      360

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctaccc cagagaagcc      420

aaagtgcagt ggaaggtgga caacgccctg cagagcggaa acagccagga aagcgtgaca      480

gagcaggatt ccaaggattc cacatacagc ctgagcagca cactgacact gtccaaggcc      540

gactacgaga agcacaaggt gtacgcctgc gaagtgacac accagggact gtcctcccct      600

gtgacaaaga gcttcaacag aggagaatgc                                       630


<210>  98
<211>  452
<212>  PRT
<213>  homo sapiens

<400>  98

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Val Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Glu Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  99
<211>  1356
<212>  DNA
<213>  homo sapiens

<400>  99
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc       60

tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagacg tatatagaga gattgcgtac      240

atggacatca gaggccttaa acctgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tccgcggcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc      420

tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg      480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag      540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc      600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt      660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      720

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      960

ggcgaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1080

gaggagatga ccaagaacca ggtcagcctg acctgccttg tcaaaggctt ctatcccagc     1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1200

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1320

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1356


<210>  100
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  100
cgagggcact tggtgcagtc agggactgag gtgaagaaac cgggggcctc agtgagagtc       60

tcctgcgaga cttctggata caccttcacc gcctacattt tacattggtt ccgacaggcc      120

cccggacgag ggcttgagtg gatggggtgg atcaagccaa aatatggagc cgtcaattat      180

gctcatgcat ttcagggcag ggtcaccctg accagagaca tatatagaga cactgcatac      240

atggacttga gtggcctaag attcgacgac acggccgtct attactgtgc gagagatcgc      300

gtttatgacg attcgtcttg gcaattggat ccctggggcc agggaacttc ggtcatcgtc      360

tcctca                                                                 366


<210>  101
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  101
cgagggcact tggtgcagtc agggactgag gtgaagaaac cgggggcctc agtgagagtc       60

tcctgcgaga cttctggata caccttcacc gcccacattt tacattggtt ccgacaggcc      120

cccggacgag ggcttgagtg gatggggtgg atcaagccaa aatatggagc cgtcaattat      180

gctcatgcat ttcagggcag ggtcaccctg accagagaca tatatagaga cactgcatac      240

atggacttga gtggcctaag attcgacgac acggccgtct attactgtgc gagagatcgc      300

gtttatgacg attcgtcttg gcaattggat ccctggggcc agggaacttc ggtcatcgtc      360

tcctca                                                                 366


<210>  102
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  102
cgagcgcact tggtgcagtc agggactgcg gtgaagaaac cgggggcctc agtgagagtc       60

tcctgcgaga cttctggata caccttcacc gcccacattt tatattggtt ccgacaggcc      120

cccggacgag ggcttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt      180

ggtggtggtt ttcggggcag ggtcaccctg accagagaca tatatagaga cactgcatac      240

atggacatca gtggcctaag attcgacgac acggccgtct attactgtgc gagagatcgc      300

tcctatgacg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tccgcg                                                                 366


<210>  103
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  103
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagagtc       60

tcctgccaga cctctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag gacttgagtg ggtggggtgg atcaagccac aatatggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagaca tatatagaga gattgcgtac      240

atggacatca gaggccttaa acttgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tccgcg                                                                 366


<210>  104
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  104

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Asp Pro Lys Leu Leu Ile 
        35                  40                  45              


Arg His Thr Thr Ser Val Glu Asp Gly Val Pro Ser Arg Val Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Ser Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  105
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  105
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagagtcacc       60

atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg      120

gggagagacc ctaaactctt gatccgccat accacttctg tggaagacgg tgtcccctca      180

agagtcagcg gctctggatt tcacacatct tttaatctga ccatcagcga cctacaggct      240

gacgacattg ccacatatta ctgtcaagtt ttacaatttt tcggccgagg gagtcgactc      300

catattaaa                                                              309


<210>  106
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  106

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  107
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  107
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagggtcacc       60

atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaagccg      120

gggagagccc ctaaactctt gattcatcat gcctcttctg tggacgacgg tgtcccgtca      180

agattcagtg gctctggatt tcacacatct tttaatctga ccatcaacga cctacaggct      240

gacgacattg ccacatatta ctgtcaggtt ttacaatttt tcggccgagg gagtcgactc      300

catattaaa                                                              309


<210>  108
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  108

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Val Gly Ser Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Ser Ser Val Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Gly Thr Tyr Tyr Cys Gln Val Leu Gln Ser Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu Asp Thr Lys 
            100             


<210>  109
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  109
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctatagggga cagagtcacc       60

atcaattgcc agacgagtca gggtgttggc agtgacctac attggtatca acacaaaccg      120

gggagagccc ctaaactcct gatccaccat gcctcttctg tggaggacgg tgtcccgtca      180

agattcagtg gcactggatt tcacacatct tttaatttga ccatcaacga cctgcaggct      240

gacgacattg gcacttatta ctgtcaggtg ttacaatctt tcggccgagg gagtcgactg      300

gatactaaa                                                              309


<210>  110
<211>  103
<212>  PRT
<213>  homo sapiens

<400>  110

Tyr Ile His Val Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Asn Cys Gln Thr Ser Gln Gly Phe Gly Arg Asp 
            20                  25                  30          


Leu His Trp Tyr Gln His Lys Pro Gly Arg Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His His Ala Pro Tyr Val Asp Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Phe His Thr Ser Phe Asn Leu Thr Ile Asn Asp Leu Gln Ala 
65                  70                  75                  80  


Asp Asp Ile Ala Thr Tyr Tyr Cys Gln Val Leu Gln Phe Phe Gly Arg 
                85                  90                  95      


Gly Ser Arg Leu His Ile Lys 
            100             


<210>  111
<211>  309
<212>  DNA
<213>  homo sapiens

<400>  111
tacatccacg tgacccagtc tccgtcctcc ctgtctgtgt ctattggaga cagggtcacc       60

atcaattgcc agacgagtca gggttttggc agggacctac attggtatca acacaagccg      120

gggagagccc ctaaactctt gattcatcat gccccttatg tggacgacgg tgtcccttca      180

agattcagtg gctctggatt tcacacatct tttaatctga ccatcaacga cctacaggct      240

gacgacattg ccacatatta ctgtcaggtt ttacaatttt tcggccgagg gagtcgactc      300

catattaaa                                                              309


<210>  112
<211>  121
<212>  PRT
<213>  homo sapiens

<400>  112

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Leu Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser 
        115                 120     


<210>  113
<211>  363
<212>  DNA
<213>  homo sapiens

<400>  113
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagggtc       60

tcctgccaga cttctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag ggctggagtg ggtgggatgg atcaagccac aatacggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagaca tatatagaga gattgcatac      240

atggacatca gaggccttaa acttgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tcc                                                                    363


<210>  114
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  114

Arg Ala His Leu Val Gln Ser Gly Thr Ala Met Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Val Ser Cys Gln Thr Ser Gly Tyr Thr Phe Thr Ala His 
            20                  25                  30          


Ile Leu Phe Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Lys Pro Gln Tyr Gly Ala Val Asn Phe Gly Gly Gly Phe 
    50                  55                  60                  


Arg Asp Arg Val Thr Leu Thr Arg Asp Ile Tyr Arg Glu Ile Ala Tyr 
65                  70                  75                  80  


Met Asp Ile Arg Gly Leu Lys Leu Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Ser Tyr Gly Asp Ser Ser Trp Ala Leu Asp Ala Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Val Val Ser Ala 
        115                 120         


<210>  115
<211>  366
<212>  DNA
<213>  homo sapiens

<400>  115
cgagcgcacc tggtacaatc agggactgcg atgaagaaac cgggggcctc agtaagggtc       60

tcctgccaga cttctggata cacctttacc gcccacatat tattttggtt ccgacaggcc      120

cccgggcgag ggctggagtg ggtgggatgg atcaagccac aatacggggc cgtgaatttt      180

ggtggtggtt ttcgggacag ggtcacattg actcgagaca tatatagaga gattgcatac      240

atggacatca gaggccttaa acttgacgac acggccgtct attactgtgc gagagaccgt      300

tcctatggcg actcctcttg ggccttagat gcctggggac agggaacgac ggtcgtcgtc      360

tccgcg                                                                 366


