                         SEQUENCE LISTING

<110>  F. Hoffmann-La Roche AG
 
<120>  Antigen Binding Molecules comprising a trimeric TNF family ligand

<130>  P32693-WO

<150>  EP15161880.8
<151>  2015-03-31

<160>  183   

<170>  PatentIn version 3.5

<210>  1
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu 
            180                 


<210>  2
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170 


<210>  3
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                165                 170                 175 


<210>  4
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  4

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200             


<210>  5
<211>  572
<212>  PRT
<213>  Artificial sequence

<220>
<223>  trimeric hu 4-1BBL (71-254) connected by (G4S)2 linker

<400>  5

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
        195                 200                 205             


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
    210                 215                 220                 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
225                 230                 235                 240 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                245                 250                 255     


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
            260                 265                 270         


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
        275                 280                 285             


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
    290                 295                 300                 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
305                 310                 315                 320 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                325                 330                 335     


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
            340                 345                 350         


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
        355                 360                 365             


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
385                 390                 395                 400 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                405                 410                 415     


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            420                 425                 430         


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        435                 440                 445             


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    450                 455                 460                 


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
465                 470                 475                 480 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                485                 490                 495     


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            500                 505                 510         


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        515                 520                 525             


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    530                 535                 540                 


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
545                 550                 555                 560 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                565                 570         


<210>  6
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu 
    130             


<210>  7
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
1               5                   10                  15      


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
            20                  25                  30          


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
        35                  40                  45              


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
    50                  55                  60                  


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
65                  70                  75                  80  


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
                85                  90                  95      


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
            100                 105                 110         


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
        115                 120                 125             


Phe Cys Val Leu 
    130         


<210>  8
<211>  419
<212>  PRT
<213>  Artificial sequence

<220>
<223>  trimeric huOX40L((51-183) connected by (G4S)2 linker

<400>  8

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
145                 150                 155                 160 


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
                165                 170                 175     


Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly 
            180                 185                 190         


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile 
        195                 200                 205             


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
    210                 215                 220                 


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
225                 230                 235                 240 


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
                245                 250                 255     


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
            260                 265                 270         


Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu 
    290                 295                 300                 


Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu 
305                 310                 315                 320 


Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe 
                325                 330                 335     


Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser 
            340                 345                 350         


Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
        355                 360                 365             


Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys 
    370                 375                 380                 


Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His 
385                 390                 395                 400 


Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
                405                 410                 415     


Cys Val Leu 
            


<210>  9
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) CDR-H1

<400>  9

Ser His Ala Met Ser 
1               5   


<210>  10
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) CDR-H2

<400>  10

Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  11
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) CDR-H3

<400>  11

Gly Trp Leu Gly Asn Phe Asp Tyr 
1               5               


<210>  12
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) CDR-L1

<400>  12

Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala 
1               5                   10          


<210>  13
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) CDR-L2

<400>  13

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) CDR-L3

<400>  14

Gln Gln Gly Gln Val Ile Pro Pro Thr 
1               5                   


<210>  15
<211>  809
<212>  PRT
<213>  Artificial sequence

<220>
<223>  trimeric hu 4-1BBL(71-254) plus Fc knob chain

<400>  15

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly 
            180                 185                 190         


Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu 
        195                 200                 205             


Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
    210                 215                 220                 


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
225                 230                 235                 240 


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
                245                 250                 255     


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
            260                 265                 270         


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
        275                 280                 285             


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
    290                 295                 300                 


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
305                 310                 315                 320 


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
                325                 330                 335     


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
            340                 345                 350         


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
        355                 360                 365             


Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala 
385                 390                 395                 400 


Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln 
                405                 410                 415     


Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly 
            420                 425                 430         


Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr 
        435                 440                 445             


Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln 
    450                 455                 460                 


Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser 
465                 470                 475                 480 


Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala 
                485                 490                 495     


Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn 
            500                 505                 510         


Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln 
        515                 520                 525             


Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp 
    530                 535                 540                 


Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro 
545                 550                 555                 560 


Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Ser Pro Gly 
                565                 570                 575     


Ser Ser Ser Ser Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
            580                 585                 590         


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        595                 600                 605             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    610                 615                 620                 


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
625                 630                 635                 640 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                645                 650                 655     


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            660                 665                 670         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        675                 680                 685             


Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    690                 695                 700                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
705                 710                 715                 720 


Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro 
                725                 730                 735     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            740                 745                 750         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        755                 760                 765             


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
    770                 775                 780                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
785                 790                 795                 800 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                805                 


<210>  16
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) VH

<400>  16

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  17
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  FAP(28H1) VL

<400>  17

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  18
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-FAP(28H1) Fc hole chain

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Trp Ala Ser Gly Glu Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Trp Leu Gly Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  19
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-FAP(28H1) light chain

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Ile Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Gln Val Ile Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  20
<211>  656
<212>  PRT
<213>  Artificial sequence

<220>
<223>  trimeric hu OX40L(51-183) plus Fc knob chain

<400>  20

Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe 
1               5                   10                  15      


Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu 
            20                  25                  30          


Asp Glu Ile Met Lys Val Gln Asp Asn Ser Val Ile Ile Asn Cys Asp 
        35                  40                  45              


Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asp 
    50                  55                  60                  


Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys 
65                  70                  75                  80  


Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys 
                85                  90                  95      


Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp 
            100                 105                 110         


Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly 
        115                 120                 125             


Glu Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr 
145                 150                 155                 160 


Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp 
                165                 170                 175     


Glu Ile Met Lys Val Gln Asp Asn Ser Val Ile Ile Asn Cys Asp Gly 
            180                 185                 190         


Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asp Ile 
        195                 200                 205             


Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys 
    210                 215                 220                 


Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp 
225                 230                 235                 240 


Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe 
                245                 250                 255     


His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu 
            260                 265                 270         


Phe Cys Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val 
        275                 280                 285             


Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu 
    290                 295                 300                 


Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu 
305                 310                 315                 320 


Ile Met Lys Val Gln Asp Asn Ser Val Ile Ile Asn Cys Asp Gly Phe 
                325                 330                 335     


Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu Val Asp Ile Ser 
            340                 345                 350         


Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val 
        355                 360                 365             


Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys 
    370                 375                 380                 


Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His 
385                 390                 395                 400 


Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe 
                405                 410                 415     


Cys Val Leu Gly Ser Pro Gly Ser Ser Ser Ser Gly Ser Asp Lys Thr 
            420                 425                 430         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
        435                 440                 445             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    450                 455                 460                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
465                 470                 475                 480 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                485                 490                 495     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            500                 505                 510         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        515                 520                 525             


Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr 
    530                 535                 540                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
545                 550                 555                 560 


Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys 
                565                 570                 575     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            580                 585                 590         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        595                 600                 605             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    610                 615                 620                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
625                 630                 635                 640 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650                 655     


<210>  21
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  22
<211>  748
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hu FAP ectodomain + poly-lys-tag + his tag

<400>  22

Arg Pro Ser Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 
                725                 730                 735     


Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745             


<210>  23
<211>  2244
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA hu FAP ectodomain + poly-lys-tag + his tag

<400>  23
cgcccttcaa gagttcataa ctctgaagaa aatacaatga gagcactcac actgaaggat       60

attttaaatg gaacattttc ttataaaaca ttttttccaa actggatttc aggacaagaa      120

tatcttcatc aatctgcaga taacaatata gtactttata atattgaaac aggacaatca      180

tataccattt tgagtaatag aaccatgaaa agtgtgaatg cttcaaatta cggcttatca      240

cctgatcggc aatttgtata tctagaaagt gattattcaa agctttggag atactcttac      300

acagcaacat attacatcta tgaccttagc aatggagaat ttgtaagagg aaatgagctt      360

cctcgtccaa ttcagtattt atgctggtcg cctgttggga gtaaattagc atatgtctat      420

caaaacaata tctatttgaa acaaagacca ggagatccac cttttcaaat aacatttaat      480

ggaagagaaa ataaaatatt taatggaatc ccagactggg tttatgaaga ggaaatgctt      540

gctacaaaat atgctctctg gtggtctcct aatggaaaat ttttggcata tgcggaattt      600

aatgatacgg atataccagt tattgcctat tcctattatg gcgatgaaca atatcctaga      660

acaataaata ttccataccc aaaggctgga gctaagaatc ccgttgttcg gatatttatt      720

atcgatacca cttaccctgc gtatgtaggt ccccaggaag tgcctgttcc agcaatgata      780

gcctcaagtg attattattt cagttggctc acgtgggtta ctgatgaacg agtatgtttg      840

cagtggctaa aaagagtcca gaatgtttcg gtcctgtcta tatgtgactt cagggaagac      900

tggcagacat gggattgtcc aaagacccag gagcatatag aagaaagcag aactggatgg      960

gctggtggat tctttgtttc aacaccagtt ttcagctatg atgccatttc gtactacaaa     1020

atatttagtg acaaggatgg ctacaaacat attcactata tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccataaata tattcagagt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa gaataccctg gaagaagaaa catctacaga     1200

attagcattg gaagctatcc tccaagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc gactacgcca agtactatgc acttgtctgc     1320

tacggcccag gcatccccat ttccaccctt catgatggac gcactgatca agaaattaaa     1380

atcctggaag aaaacaagga attggaaaat gctttgaaaa atatccagct gcctaaagag     1440

gaaattaaga aacttgaagt agatgaaatt actttatggt acaagatgat tcttcctcct     1500

caatttgaca gatcaaagaa gtatcccttg ctaattcaag tgtatggtgg tccctgcagt     1560

cagagtgtaa ggtctgtatt tgctgttaat tggatatctt atcttgcaag taaggaaggg     1620

atggtcattg ccttggtgga tggtcgagga acagctttcc aaggtgacaa actcctctat     1680

gcagtgtatc gaaagctggg tgtttatgaa gttgaagacc agattacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaaaaa agaatagcca tatggggctg gtcctatgga     1800

ggatacgttt catcactggc ccttgcatct ggaactggtc ttttcaaatg tggtatagca     1860

gtggctccag tctccagctg ggaatattac gcgtctgtct acacagagag attcatgggt     1920

ctcccaacaa aggatgataa tcttgagcac tataagaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcaaaact cagcacagat tgctaaagct ctggttaatg cacaagtgga tttccaggca     2100

atgtggtact ctgaccagaa ccacggctta tccggcctgt ccacgaacca cttatacacc     2160

cacatgaccc acttcctaaa gcagtgtttc tctttgtcag acggcaaaaa gaaaaagaaa     2220

aagggccacc accatcacca tcac                                            2244


<210>  24
<211>  761
<212>  PRT
<213>  mus musculus

<400>  24

Met Lys Thr Trp Leu Lys Thr Val Phe Gly Val Thr Thr Leu Ala Ala 
1               5                   10                  15      


Leu Ala Leu Val Val Ile Cys Ile Val Leu Arg Pro Ser Arg Val Tyr 
            20                  25                  30          


Lys Pro Glu Gly Asn Thr Lys Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Tyr Phe Pro Asn Trp Ile Ser Glu 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Glu Asp Asp Asn Ile Val Phe Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu Ser Asn Ser Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Thr Asp Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly Glu Phe Val Arg Gly Tyr 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Tyr Thr Gly Arg Glu Asn Arg Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asp Gly Lys Phe Leu Ala Tyr Val 
    210                 215                 220                 


Glu Phe Asn Asp Ser Asp Ile Pro Ile Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Gly Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Val Phe Ile Val Asp Thr Thr Tyr Pro 
            260                 265                 270         


His His Val Gly Pro Met Glu Val Pro Val Pro Glu Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Ser Ser Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp His Ala Trp Glu Cys Pro Lys Asn Gln 
                325                 330                 335     


Glu His Val Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Ala Phe Ser Gln Asp Ala Thr Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Tyr Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Asn Ser 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr Lys Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Leu Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Gln Val Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ser Leu Arg Asn Ile Gln Leu Pro Lys Val Glu Ile Lys Lys Leu Lys 
            500                 505                 510         


Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Lys Ser Val Phe Ala Val Asn Trp Ile Thr Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Ile Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Phe Leu His Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Leu Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Glu Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Ile 
                725                 730                 735     


Ser Ser Gly Arg Ser Gln Asn His Leu Tyr Thr His Met Thr His Phe 
            740                 745                 750         


Leu Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760     


<210>  25
<211>  749
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine FAP ectodomain + poly-lys-tag + his tag

<400>  25

Arg Pro Ser Arg Val Tyr Lys Pro Glu Gly Asn Thr Lys Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Tyr Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Glu Gln Glu Tyr Leu His Gln Ser Glu Asp Asp 
        35                  40                  45              


Asn Ile Val Phe Tyr Asn Ile Glu Thr Arg Glu Ser Tyr Ile Ile Leu 
    50                  55                  60                  


Ser Asn Ser Thr Met Lys Ser Val Asn Ala Thr Asp Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Gln Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Tyr Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Tyr Thr 
145                 150                 155                 160 


Gly Arg Glu Asn Arg Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asp Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Val Glu Phe Asn Asp Ser Asp Ile Pro Ile Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Gly Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Val Val Arg Val Phe Ile 
225                 230                 235                 240 


Val Asp Thr Thr Tyr Pro His His Val Gly Pro Met Glu Val Pro Val 
                245                 250                 255     


Pro Glu Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Ser Ser Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp His Ala Trp 
    290                 295                 300                 


Glu Cys Pro Lys Asn Gln Glu His Val Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Ala Phe Ser Gln Asp Ala Thr 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Tyr Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Gly Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Asn Ser Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Tyr Lys 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Leu Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Gln Val Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ser Leu Arg Asn Ile Gln Leu Pro Lys Val 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Lys Asp Gly Gly Leu Thr Phe Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Lys Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Thr Tyr Leu Ala Ser Lys Glu Gly Ile Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Phe Leu His 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Leu Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Glu Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Ile Tyr Ser Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Ile Leu Ser Gly Arg Ser Gln Asn His Leu Tyr 
705                 710                 715                 720 


Thr His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly 
                725                 730                 735     


Lys Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745                 


<210>  26
<211>  2247
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Murine FAP ectodomain + poly-lys-tag + his tag

<400>  26
cgtccctcaa gagtttacaa acctgaagga aacacaaaga gagctcttac cttgaaggat       60

attttaaatg gaacattctc atataaaaca tattttccca actggatttc agaacaagaa      120

tatcttcatc aatctgagga tgataacata gtattttata atattgaaac aagagaatca      180

tatatcattt tgagtaatag caccatgaaa agtgtgaatg ctacagatta tggtttgtca      240

cctgatcggc aatttgtgta tctagaaagt gattattcaa agctctggcg atattcatac      300

acagcgacat actacatcta cgaccttcag aatggggaat ttgtaagagg atacgagctc      360

cctcgtccaa ttcagtatct atgctggtcg cctgttggga gtaaattagc atatgtatat      420

caaaacaata tttatttgaa acaaagacca ggagatccac cttttcaaat aacttatact      480

ggaagagaaa atagaatatt taatggaata ccagactggg tttatgaaga ggaaatgctt      540

gccacaaaat atgctctttg gtggtctcca gatggaaaat ttttggcata tgtagaattt      600

aatgattcag atataccaat tattgcctat tcttattatg gtgatggaca gtatcctaga      660

actataaata ttccatatcc aaaggctggg gctaagaatc cggttgttcg tgtttttatt      720

gttgacacca cctaccctca ccacgtgggc ccaatggaag tgccagttcc agaaatgata      780

gcctcaagtg actattattt cagctggctc acatgggtgt ccagtgaacg agtatgcttg      840

cagtggctaa aaagagtgca gaatgtctca gtcctgtcta tatgtgattt cagggaagac      900

tggcatgcat gggaatgtcc aaagaaccag gagcatgtag aagaaagcag aacaggatgg      960

gctggtggat tctttgtttc gacaccagct tttagccagg atgccacttc ttactacaaa     1020

atatttagcg acaaggatgg ttacaaacat attcactaca tcaaagacac tgtggaaaat     1080

gctattcaaa ttacaagtgg caagtgggag gccatatata tattccgcgt aacacaggat     1140

tcactgtttt attctagcaa tgaatttgaa ggttaccctg gaagaagaaa catctacaga     1200

attagcattg gaaactctcc tccgagcaag aagtgtgtta cttgccatct aaggaaagaa     1260

aggtgccaat attacacagc aagtttcagc tacaaagcca agtactatgc actcgtctgc     1320

tatggccctg gcctccccat ttccaccctc catgatggcc gcacagacca agaaatacaa     1380

gtattagaag aaaacaaaga actggaaaat tctctgagaa atatccagct gcctaaagtg     1440

gagattaaga agctcaaaga cgggggactg actttctggt acaagatgat tctgcctcct     1500

cagtttgaca gatcaaagaa gtaccctttg ctaattcaag tgtatggtgg tccttgtagc     1560

cagagtgtta agtctgtgtt tgctgttaat tggataactt atctcgcaag taaggagggg     1620

atagtcattg ccctggtaga tggtcggggc actgctttcc aaggtgacaa attcctgcat     1680

gccgtgtatc gaaaactggg tgtatatgaa gttgaggacc agctcacagc tgtcagaaaa     1740

ttcatagaaa tgggtttcat tgatgaagaa agaatagcca tatggggctg gtcctacgga     1800

ggttatgttt catccctggc ccttgcatct ggaactggtc ttttcaaatg tggcatagca     1860

gtggctccag tctccagctg ggaatattac gcatctatct actcagagag attcatgggc     1920

ctcccaacaa aggacgacaa tctcgaacac tataaaaatt caactgtgat ggcaagagca     1980

gaatatttca gaaatgtaga ctatcttctc atccacggaa cagcagatga taatgtgcac     2040

tttcagaact cagcacagat tgctaaagct ttggttaatg cacaagtgga tttccaggcg     2100

atgtggtact ctgaccagaa ccatggtata ttatctgggc gctcccagaa tcatttatat     2160

acccacatga cgcacttcct caagcaatgc ttttctttat cagacggcaa aaagaaaaag     2220

aaaaagggcc accaccatca ccatcac                                         2247


<210>  27
<211>  748
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cynomolgus FAP ectodomain + poly-lys-tag + his tag

<400>  27

Arg Pro Pro Arg Val His Asn Ser Glu Glu Asn Thr Met Arg Ala Leu 
1               5                   10                  15      


Thr Leu Lys Asp Ile Leu Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe 
            20                  25                  30          


Pro Asn Trp Ile Ser Gly Gln Glu Tyr Leu His Gln Ser Ala Asp Asn 
        35                  40                  45              


Asn Ile Val Leu Tyr Asn Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu 
    50                  55                  60                  


Ser Asn Arg Thr Met Lys Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser 
65                  70                  75                  80  


Pro Asp Arg Gln Phe Val Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp 
                85                  90                  95      


Arg Tyr Ser Tyr Thr Ala Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly 
            100                 105                 110         


Glu Phe Val Arg Gly Asn Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys 
        115                 120                 125             


Trp Ser Pro Val Gly Ser Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile 
    130                 135                 140                 


Tyr Leu Lys Gln Arg Pro Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn 
145                 150                 155                 160 


Gly Arg Glu Asn Lys Ile Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu 
                165                 170                 175     


Glu Glu Met Leu Ala Thr Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly 
            180                 185                 190         


Lys Phe Leu Ala Tyr Ala Glu Phe Asn Asp Thr Asp Ile Pro Val Ile 
        195                 200                 205             


Ala Tyr Ser Tyr Tyr Gly Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile 
    210                 215                 220                 


Pro Tyr Pro Lys Ala Gly Ala Lys Asn Pro Phe Val Arg Ile Phe Ile 
225                 230                 235                 240 


Ile Asp Thr Thr Tyr Pro Ala Tyr Val Gly Pro Gln Glu Val Pro Val 
                245                 250                 255     


Pro Ala Met Ile Ala Ser Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp 
            260                 265                 270         


Val Thr Asp Glu Arg Val Cys Leu Gln Trp Leu Lys Arg Val Gln Asn 
        275                 280                 285             


Val Ser Val Leu Ser Ile Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp 
    290                 295                 300                 


Asp Cys Pro Lys Thr Gln Glu His Ile Glu Glu Ser Arg Thr Gly Trp 
305                 310                 315                 320 


Ala Gly Gly Phe Phe Val Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile 
                325                 330                 335     


Ser Tyr Tyr Lys Ile Phe Ser Asp Lys Asp Gly Tyr Lys His Ile His 
            340                 345                 350         


Tyr Ile Lys Asp Thr Val Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys 
        355                 360                 365             


Trp Glu Ala Ile Asn Ile Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr 
    370                 375                 380                 


Ser Ser Asn Glu Phe Glu Asp Tyr Pro Gly Arg Arg Asn Ile Tyr Arg 
385                 390                 395                 400 


Ile Ser Ile Gly Ser Tyr Pro Pro Ser Lys Lys Cys Val Thr Cys His 
                405                 410                 415     


Leu Arg Lys Glu Arg Cys Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr 
            420                 425                 430         


Ala Lys Tyr Tyr Ala Leu Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser 
        435                 440                 445             


Thr Leu His Asp Gly Arg Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu 
    450                 455                 460                 


Asn Lys Glu Leu Glu Asn Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu 
465                 470                 475                 480 


Glu Ile Lys Lys Leu Glu Val Asp Glu Ile Thr Leu Trp Tyr Lys Met 
                485                 490                 495     


Ile Leu Pro Pro Gln Phe Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile 
            500                 505                 510         


Gln Val Tyr Gly Gly Pro Cys Ser Gln Ser Val Arg Ser Val Phe Ala 
        515                 520                 525             


Val Asn Trp Ile Ser Tyr Leu Ala Ser Lys Glu Gly Met Val Ile Ala 
    530                 535                 540                 


Leu Val Asp Gly Arg Gly Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr 
545                 550                 555                 560 


Ala Val Tyr Arg Lys Leu Gly Val Tyr Glu Val Glu Asp Gln Ile Thr 
                565                 570                 575     


Ala Val Arg Lys Phe Ile Glu Met Gly Phe Ile Asp Glu Lys Arg Ile 
            580                 585                 590         


Ala Ile Trp Gly Trp Ser Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu 
        595                 600                 605             


Ala Ser Gly Thr Gly Leu Phe Lys Cys Gly Ile Ala Val Ala Pro Val 
    610                 615                 620                 


Ser Ser Trp Glu Tyr Tyr Ala Ser Val Tyr Thr Glu Arg Phe Met Gly 
625                 630                 635                 640 


Leu Pro Thr Lys Asp Asp Asn Leu Glu His Tyr Lys Asn Ser Thr Val 
                645                 650                 655     


Met Ala Arg Ala Glu Tyr Phe Arg Asn Val Asp Tyr Leu Leu Ile His 
            660                 665                 670         


Gly Thr Ala Asp Asp Asn Val His Phe Gln Asn Ser Ala Gln Ile Ala 
        675                 680                 685             


Lys Ala Leu Val Asn Ala Gln Val Asp Phe Gln Ala Met Trp Tyr Ser 
    690                 695                 700                 


Asp Gln Asn His Gly Leu Ser Gly Leu Ser Thr Asn His Leu Tyr Thr 
705                 710                 715                 720 


His Met Thr His Phe Leu Lys Gln Cys Phe Ser Leu Ser Asp Gly Lys 
                725                 730                 735     


Lys Lys Lys Lys Lys Gly His His His His His His 
            740                 745             


<210>  28
<211>  2244
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cynomolgus FAP ectodomain + poly-lys-tag + his tag

<400>  28

Cys Gly Cys Cys Cys Thr Cys Cys Ala Ala Gly Ala Gly Thr Thr Cys 
1               5                   10                  15      


Ala Thr Ala Ala Cys Thr Cys Thr Gly Ala Ala Gly Ala Ala Ala Ala 
            20                  25                  30          


Thr Ala Cys Ala Ala Thr Gly Ala Gly Ala Gly Cys Ala Cys Thr Cys 
        35                  40                  45              


Ala Cys Ala Cys Thr Gly Ala Ala Gly Gly Ala Thr Ala Thr Thr Thr 
    50                  55                  60                  


Thr Ala Ala Ala Thr Gly Gly Gly Ala Cys Ala Thr Thr Thr Thr Cys 
65                  70                  75                  80  


Thr Thr Ala Thr Ala Ala Ala Ala Cys Ala Thr Thr Thr Thr Thr Thr 
                85                  90                  95      


Cys Cys Ala Ala Ala Cys Thr Gly Gly Ala Thr Thr Thr Cys Ala Gly 
            100                 105                 110         


Gly Ala Cys Ala Ala Gly Ala Ala Thr Ala Thr Cys Thr Thr Cys Ala 
        115                 120                 125             


Thr Cys Ala Ala Thr Cys Thr Gly Cys Ala Gly Ala Thr Ala Ala Cys 
    130                 135                 140                 


Ala Ala Thr Ala Thr Ala Gly Thr Ala Cys Thr Thr Thr Ala Thr Ala 
145                 150                 155                 160 


Ala Thr Ala Thr Thr Gly Ala Ala Ala Cys Ala Gly Gly Ala Cys Ala 
                165                 170                 175     


Ala Thr Cys Ala Thr Ala Thr Ala Cys Cys Ala Thr Thr Thr Thr Gly 
            180                 185                 190         


Ala Gly Thr Ala Ala Cys Ala Gly Ala Ala Cys Cys Ala Thr Gly Ala 
        195                 200                 205             


Ala Ala Ala Gly Thr Gly Thr Gly Ala Ala Thr Gly Cys Thr Thr Cys 
    210                 215                 220                 


Ala Ala Ala Thr Thr Ala Thr Gly Gly Cys Thr Thr Ala Thr Cys Ala 
225                 230                 235                 240 


Cys Cys Thr Gly Ala Thr Cys Gly Gly Cys Ala Ala Thr Thr Thr Gly 
                245                 250                 255     


Thr Ala Thr Ala Thr Cys Thr Ala Gly Ala Ala Ala Gly Thr Gly Ala 
            260                 265                 270         


Thr Thr Ala Thr Thr Cys Ala Ala Ala Gly Cys Thr Thr Thr Gly Gly 
        275                 280                 285             


Ala Gly Ala Thr Ala Cys Thr Cys Thr Thr Ala Cys Ala Cys Ala Gly 
    290                 295                 300                 


Cys Ala Ala Cys Ala Thr Ala Thr Thr Ala Cys Ala Thr Cys Thr Ala 
305                 310                 315                 320 


Thr Gly Ala Cys Cys Thr Thr Ala Gly Cys Ala Ala Thr Gly Gly Ala 
                325                 330                 335     


Gly Ala Ala Thr Thr Thr Gly Thr Ala Ala Gly Ala Gly Gly Ala Ala 
            340                 345                 350         


Ala Thr Gly Ala Gly Cys Thr Thr Cys Cys Thr Cys Gly Thr Cys Cys 
        355                 360                 365             


Ala Ala Thr Thr Cys Ala Gly Thr Ala Thr Thr Thr Ala Thr Gly Cys 
    370                 375                 380                 


Thr Gly Gly Thr Cys Gly Cys Cys Thr Gly Thr Thr Gly Gly Gly Ala 
385                 390                 395                 400 


Gly Thr Ala Ala Ala Thr Thr Ala Gly Cys Ala Thr Ala Thr Gly Thr 
                405                 410                 415     


Cys Thr Ala Thr Cys Ala Ala Ala Ala Cys Ala Ala Thr Ala Thr Cys 
            420                 425                 430         


Thr Ala Thr Thr Thr Gly Ala Ala Ala Cys Ala Ala Ala Gly Ala Cys 
        435                 440                 445             


Cys Ala Gly Gly Ala Gly Ala Thr Cys Cys Ala Cys Cys Thr Thr Thr 
    450                 455                 460                 


Thr Cys Ala Ala Ala Thr Ala Ala Cys Ala Thr Thr Thr Ala Ala Thr 
465                 470                 475                 480 


Gly Gly Ala Ala Gly Ala Gly Ala Ala Ala Ala Thr Ala Ala Ala Ala 
                485                 490                 495     


Thr Ala Thr Thr Thr Ala Ala Thr Gly Gly Ala Ala Thr Cys Cys Cys 
            500                 505                 510         


Ala Gly Ala Cys Thr Gly Gly Gly Thr Thr Thr Ala Thr Gly Ala Ala 
        515                 520                 525             


Gly Ala Gly Gly Ala Ala Ala Thr Gly Cys Thr Thr Gly Cys Thr Ala 
    530                 535                 540                 


Cys Ala Ala Ala Ala Thr Ala Thr Gly Cys Thr Cys Thr Cys Thr Gly 
545                 550                 555                 560 


Gly Thr Gly Gly Thr Cys Thr Cys Cys Thr Ala Ala Thr Gly Gly Ala 
                565                 570                 575     


Ala Ala Ala Thr Thr Thr Thr Thr Gly Gly Cys Ala Thr Ala Thr Gly 
            580                 585                 590         


Cys Gly Gly Ala Ala Thr Thr Thr Ala Ala Thr Gly Ala Thr Ala Cys 
        595                 600                 605             


Ala Gly Ala Thr Ala Thr Ala Cys Cys Ala Gly Thr Thr Ala Thr Thr 
    610                 615                 620                 


Gly Cys Cys Thr Ala Thr Thr Cys Cys Thr Ala Thr Thr Ala Thr Gly 
625                 630                 635                 640 


Gly Cys Gly Ala Thr Gly Ala Ala Cys Ala Ala Thr Ala Thr Cys Cys 
                645                 650                 655     


Cys Ala Gly Ala Ala Cys Ala Ala Thr Ala Ala Ala Thr Ala Thr Thr 
            660                 665                 670         


Cys Cys Ala Thr Ala Cys Cys Cys Ala Ala Ala Gly Gly Cys Cys Gly 
        675                 680                 685             


Gly Ala Gly Cys Thr Ala Ala Gly Ala Ala Thr Cys Cys Thr Thr Thr 
    690                 695                 700                 


Thr Gly Thr Thr Cys Gly Gly Ala Thr Ala Thr Thr Thr Ala Thr Thr 
705                 710                 715                 720 


Ala Thr Cys Gly Ala Thr Ala Cys Cys Ala Cys Thr Thr Ala Cys Cys 
                725                 730                 735     


Cys Thr Gly Cys Gly Thr Ala Thr Gly Thr Ala Gly Gly Thr Cys Cys 
            740                 745                 750         


Cys Cys Ala Gly Gly Ala Ala Gly Thr Gly Cys Cys Thr Gly Thr Thr 
        755                 760                 765             


Cys Cys Ala Gly Cys Ala Ala Thr Gly Ala Thr Ala Gly Cys Cys Thr 
    770                 775                 780                 


Cys Ala Ala Gly Thr Gly Ala Thr Thr Ala Thr Thr Ala Thr Thr Thr 
785                 790                 795                 800 


Cys Ala Gly Thr Thr Gly Gly Cys Thr Cys Ala Cys Gly Thr Gly Gly 
                805                 810                 815     


Gly Thr Thr Ala Cys Thr Gly Ala Thr Gly Ala Ala Cys Gly Ala Gly 
            820                 825                 830         


Thr Ala Thr Gly Thr Thr Thr Gly Cys Ala Gly Thr Gly Gly Cys Thr 
        835                 840                 845             


Ala Ala Ala Ala Ala Gly Ala Gly Thr Cys Cys Ala Gly Ala Ala Thr 
    850                 855                 860                 


Gly Thr Thr Thr Cys Gly Gly Thr Cys Thr Thr Gly Thr Cys Thr Ala 
865                 870                 875                 880 


Thr Ala Thr Gly Thr Gly Ala Thr Thr Thr Cys Ala Gly Gly Gly Ala 
                885                 890                 895     


Ala Gly Ala Cys Thr Gly Gly Cys Ala Gly Ala Cys Ala Thr Gly Gly 
            900                 905                 910         


Gly Ala Thr Thr Gly Thr Cys Cys Ala Ala Ala Gly Ala Cys Cys Cys 
        915                 920                 925             


Ala Gly Gly Ala Gly Cys Ala Thr Ala Thr Ala Gly Ala Ala Gly Ala 
    930                 935                 940                 


Ala Ala Gly Cys Ala Gly Ala Ala Cys Thr Gly Gly Ala Thr Gly Gly 
945                 950                 955                 960 


Gly Cys Thr Gly Gly Thr Gly Gly Ala Thr Thr Cys Thr Thr Thr Gly 
                965                 970                 975     


Thr Thr Thr Cys Ala Ala Cys Ala Cys Cys Ala Gly Thr Thr Thr Thr 
            980                 985                 990         


Cys Ala Gly Cys Thr Ala Thr Gly  Ala Thr Gly Cys Cys  Ala Thr Thr 
        995                 1000                 1005             


Thr Cys  Ala Thr Ala Cys Thr  Ala Cys Ala Ala Ala  Ala Thr Ala 
    1010                 1015                 1020             


Thr Thr  Thr Ala Gly Thr Gly  Ala Cys Ala Ala Gly  Gly Ala Thr 
    1025                 1030                 1035             


Gly Gly  Cys Thr Ala Cys Ala  Ala Ala Cys Ala Thr  Ala Thr Thr 
    1040                 1045                 1050             


Cys Ala  Cys Thr Ala Thr Ala  Thr Cys Ala Ala Ala  Gly Ala Cys 
    1055                 1060                 1065             


Ala Cys  Thr Gly Thr Gly Gly  Ala Ala Ala Ala Thr  Gly Cys Thr 
    1070                 1075                 1080             


Ala Thr  Thr Cys Ala Ala Ala  Thr Thr Ala Cys Ala  Ala Gly Thr 
    1085                 1090                 1095             


Gly Gly  Cys Ala Ala Gly Thr  Gly Gly Gly Ala Gly  Gly Cys Cys 
    1100                 1105                 1110             


Ala Thr  Ala Ala Ala Thr Ala  Thr Ala Thr Thr Cys  Ala Gly Ala 
    1115                 1120                 1125             


Gly Thr  Ala Ala Cys Ala Cys  Ala Gly Gly Ala Thr  Thr Cys Ala 
    1130                 1135                 1140             


Cys Thr  Gly Thr Thr Thr Thr  Ala Thr Thr Cys Thr  Ala Gly Cys 
    1145                 1150                 1155             


Ala Ala  Thr Gly Ala Ala Thr  Thr Thr Gly Ala Ala  Gly Ala Thr 
    1160                 1165                 1170             


Thr Ala  Cys Cys Cys Thr Gly  Gly Ala Ala Gly Ala  Ala Gly Ala 
    1175                 1180                 1185             


Ala Ala  Cys Ala Thr Cys Thr  Ala Cys Ala Gly Ala  Ala Thr Thr 
    1190                 1195                 1200             


Ala Gly  Cys Ala Thr Thr Gly  Gly Ala Ala Gly Cys  Thr Ala Thr 
    1205                 1210                 1215             


Cys Cys  Thr Cys Cys Ala Ala  Gly Cys Ala Ala Gly  Ala Ala Gly 
    1220                 1225                 1230             


Thr Gly  Thr Gly Thr Thr Ala  Cys Thr Thr Gly Cys  Cys Ala Thr 
    1235                 1240                 1245             


Cys Thr  Ala Ala Gly Gly Ala  Ala Ala Gly Ala Ala  Ala Gly Gly 
    1250                 1255                 1260             


Thr Gly  Cys Cys Ala Ala Thr  Ala Thr Thr Ala Cys  Ala Cys Ala 
    1265                 1270                 1275             


Gly Cys  Ala Ala Gly Thr Thr  Thr Cys Ala Gly Cys  Gly Ala Cys 
    1280                 1285                 1290             


Thr Ala  Cys Gly Cys Cys Ala  Ala Gly Thr Ala Cys  Thr Ala Thr 
    1295                 1300                 1305             


Gly Cys  Ala Cys Thr Thr Gly  Thr Cys Thr Gly Cys  Thr Ala Thr 
    1310                 1315                 1320             


Gly Gly  Cys Cys Cys Ala Gly  Gly Cys Ala Thr Cys  Cys Cys Cys 
    1325                 1330                 1335             


Ala Thr  Thr Thr Cys Cys Ala  Cys Cys Cys Thr Thr  Cys Ala Thr 
    1340                 1345                 1350             


Gly Ala  Cys Gly Gly Ala Cys  Gly Cys Ala Cys Thr  Gly Ala Thr 
    1355                 1360                 1365             


Cys Ala  Ala Gly Ala Ala Ala  Thr Thr Ala Ala Ala  Ala Thr Cys 
    1370                 1375                 1380             


Cys Thr  Gly Gly Ala Ala Gly  Ala Ala Ala Ala Cys  Ala Ala Gly 
    1385                 1390                 1395             


Gly Ala  Ala Thr Thr Gly Gly  Ala Ala Ala Ala Thr  Gly Cys Thr 
    1400                 1405                 1410             


Thr Thr  Gly Ala Ala Ala Ala  Ala Thr Ala Thr Cys  Cys Ala Gly 
    1415                 1420                 1425             


Cys Thr  Gly Cys Cys Thr Ala  Ala Ala Gly Ala Gly  Gly Ala Ala 
    1430                 1435                 1440             


Ala Thr  Thr Ala Ala Gly Ala  Ala Ala Cys Thr Thr  Gly Ala Ala 
    1445                 1450                 1455             


Gly Thr  Ala Gly Ala Thr Gly  Ala Ala Ala Thr Thr  Ala Cys Thr 
    1460                 1465                 1470             


Thr Thr  Ala Thr Gly Gly Thr  Ala Cys Ala Ala Gly  Ala Thr Gly 
    1475                 1480                 1485             


Ala Thr  Thr Cys Thr Thr Cys  Cys Thr Cys Cys Thr  Cys Ala Ala 
    1490                 1495                 1500             


Thr Thr  Thr Gly Ala Cys Ala  Gly Ala Thr Cys Ala  Ala Ala Gly 
    1505                 1510                 1515             


Ala Ala  Gly Thr Ala Thr Cys  Cys Cys Thr Thr Gly  Cys Thr Ala 
    1520                 1525                 1530             


Ala Thr  Thr Cys Ala Ala Gly  Thr Gly Thr Ala Thr  Gly Gly Thr 
    1535                 1540                 1545             


Gly Gly  Thr Cys Cys Cys Thr  Gly Cys Ala Gly Thr  Cys Ala Gly 
    1550                 1555                 1560             


Ala Gly  Thr Gly Thr Ala Ala  Gly Gly Thr Cys Thr  Gly Thr Ala 
    1565                 1570                 1575             


Thr Thr  Thr Gly Cys Thr Gly  Thr Thr Ala Ala Thr  Thr Gly Gly 
    1580                 1585                 1590             


Ala Thr  Ala Thr Cys Thr Thr  Ala Thr Cys Thr Thr  Gly Cys Ala 
    1595                 1600                 1605             


Ala Gly  Thr Ala Ala Gly Gly  Ala Ala Gly Gly Gly  Ala Thr Gly 
    1610                 1615                 1620             


Gly Thr  Cys Ala Thr Thr Gly  Cys Cys Thr Thr Gly  Gly Thr Gly 
    1625                 1630                 1635             


Gly Ala  Thr Gly Gly Thr Cys  Gly Gly Gly Gly Ala  Ala Cys Ala 
    1640                 1645                 1650             


Gly Cys  Thr Thr Thr Cys Cys  Ala Ala Gly Gly Thr  Gly Ala Cys 
    1655                 1660                 1665             


Ala Ala  Ala Cys Thr Cys Cys  Thr Gly Thr Ala Thr  Gly Cys Ala 
    1670                 1675                 1680             


Gly Thr  Gly Thr Ala Thr Cys  Gly Ala Ala Ala Gly  Cys Thr Gly 
    1685                 1690                 1695             


Gly Gly  Thr Gly Thr Thr Thr  Ala Thr Gly Ala Ala  Gly Thr Thr 
    1700                 1705                 1710             


Gly Ala  Ala Gly Ala Cys Cys  Ala Gly Ala Thr Thr  Ala Cys Ala 
    1715                 1720                 1725             


Gly Cys  Thr Gly Thr Cys Ala  Gly Ala Ala Ala Ala  Thr Thr Cys 
    1730                 1735                 1740             


Ala Thr  Ala Gly Ala Ala Ala  Thr Gly Gly Gly Thr  Thr Thr Cys 
    1745                 1750                 1755             


Ala Thr  Thr Gly Ala Thr Gly  Ala Ala Ala Ala Ala  Ala Gly Ala 
    1760                 1765                 1770             


Ala Thr  Ala Gly Cys Cys Ala  Thr Ala Thr Gly Gly  Gly Gly Cys 
    1775                 1780                 1785             


Thr Gly  Gly Thr Cys Cys Thr  Ala Thr Gly Gly Ala  Gly Gly Ala 
    1790                 1795                 1800             


Thr Ala  Thr Gly Thr Thr Thr  Cys Ala Thr Cys Ala  Cys Thr Gly 
    1805                 1810                 1815             


Gly Cys  Cys Cys Thr Thr Gly  Cys Ala Thr Cys Thr  Gly Gly Ala 
    1820                 1825                 1830             


Ala Cys  Thr Gly Gly Thr Cys  Thr Thr Thr Thr Cys  Ala Ala Ala 
    1835                 1840                 1845             


Thr Gly  Thr Gly Gly Gly Ala  Thr Ala Gly Cys Ala  Gly Thr Gly 
    1850                 1855                 1860             


Gly Cys  Thr Cys Cys Ala Gly  Thr Cys Thr Cys Cys  Ala Gly Cys 
    1865                 1870                 1875             


Thr Gly  Gly Gly Ala Ala Thr  Ala Thr Thr Ala Cys  Gly Cys Gly 
    1880                 1885                 1890             


Thr Cys  Thr Gly Thr Cys Thr  Ala Cys Ala Cys Ala  Gly Ala Gly 
    1895                 1900                 1905             


Ala Gly  Ala Thr Thr Cys Ala  Thr Gly Gly Gly Thr  Cys Thr Cys 
    1910                 1915                 1920             


Cys Cys  Ala Ala Cys Ala Ala  Ala Gly Gly Ala Thr  Gly Ala Thr 
    1925                 1930                 1935             


Ala Ala  Thr Cys Thr Thr Gly  Ala Gly Cys Ala Cys  Thr Ala Thr 
    1940                 1945                 1950             


Ala Ala  Gly Ala Ala Thr Thr  Cys Ala Ala Cys Thr  Gly Thr Gly 
    1955                 1960                 1965             


Ala Thr  Gly Gly Cys Ala Ala  Gly Ala Gly Cys Ala  Gly Ala Ala 
    1970                 1975                 1980             


Thr Ala  Thr Thr Thr Cys Ala  Gly Ala Ala Ala Thr  Gly Thr Ala 
    1985                 1990                 1995             


Gly Ala  Cys Thr Ala Thr Cys  Thr Thr Cys Thr Cys  Ala Thr Cys 
    2000                 2005                 2010             


Cys Ala  Cys Gly Gly Ala Ala  Cys Ala Gly Cys Ala  Gly Ala Thr 
    2015                 2020                 2025             


Gly Ala  Thr Ala Ala Thr Gly  Thr Gly Cys Ala Cys  Thr Thr Thr 
    2030                 2035                 2040             


Cys Ala  Ala Ala Ala Cys Thr  Cys Ala Gly Cys Ala  Cys Ala Gly 
    2045                 2050                 2055             


Ala Thr  Thr Gly Cys Thr Ala  Ala Ala Gly Cys Thr  Cys Thr Gly 
    2060                 2065                 2070             


Gly Thr  Thr Ala Ala Thr Gly  Cys Ala Cys Ala Ala  Gly Thr Gly 
    2075                 2080                 2085             


Gly Ala  Thr Thr Thr Cys Cys  Ala Gly Gly Cys Ala  Ala Thr Gly 
    2090                 2095                 2100             


Thr Gly  Gly Thr Ala Cys Thr  Cys Thr Gly Ala Cys  Cys Ala Gly 
    2105                 2110                 2115             


Ala Ala  Cys Cys Ala Cys Gly  Gly Cys Thr Thr Ala  Thr Cys Cys 
    2120                 2125                 2130             


Gly Gly  Cys Cys Thr Gly Thr  Cys Cys Ala Cys Gly  Ala Ala Cys 
    2135                 2140                 2145             


Cys Ala  Cys Thr Thr Ala Thr  Ala Cys Ala Cys Cys  Cys Ala Cys 
    2150                 2155                 2160             


Ala Thr  Gly Ala Cys Cys Cys  Ala Cys Thr Thr Cys  Cys Thr Ala 
    2165                 2170                 2175             


Ala Ala  Gly Cys Ala Gly Thr  Gly Thr Thr Thr Cys  Thr Cys Thr 
    2180                 2185                 2190             


Thr Thr  Gly Thr Cys Ala Gly  Ala Cys Gly Gly Cys  Ala Ala Ala 
    2195                 2200                 2205             


Ala Ala  Gly Ala Ala Ala Ala  Ala Gly Ala Ala Ala  Ala Ala Gly 
    2210                 2215                 2220             


Gly Gly  Cys Cys Ala Cys Cys  Ala Cys Cys Ala Thr  Cys Ala Cys 
    2225                 2230                 2235             


Cys Ala  Thr Cys Ala Cys 
    2240                 


<210>  29
<211>  702
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln 
1               5                   10                  15      


Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr 
            20                  25                  30          


Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly 
        35                  40                  45              


Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly 
    50                  55                  60                  


Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile 
65                  70                  75                  80  


Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser 
                85                  90                  95      


Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile 
            100                 105                 110         


Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp 
        115                 120                 125             


Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu 
    130                 135                 140                 


Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys 
145                 150                 155                 160 


Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr 
                165                 170                 175     


Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln 
            180                 185                 190         


Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn 
        195                 200                 205             


Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg 
    210                 215                 220                 


Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro 
225                 230                 235                 240 


Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn 
                245                 250                 255     


Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe 
            260                 265                 270         


Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn 
        275                 280                 285             


Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser 
    290                 295                 300                 


Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala 
305                 310                 315                 320 


Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu 
                325                 330                 335     


Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr 
            340                 345                 350         


Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg 
        355                 360                 365             


Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr 
    370                 375                 380                 


Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Lys Leu Ser 
385                 390                 395                 400 


Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp 
                405                 410                 415     


Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn 
            420                 425                 430         


Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser 
        435                 440                 445             


Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile 
    450                 455                 460                 


Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn 
465                 470                 475                 480 


Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val 
                485                 490                 495     


Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro 
            500                 505                 510         


Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln 
        515                 520                 525             


Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser 
    530                 535                 540                 


Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn 
545                 550                 555                 560 


Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser 
                565                 570                 575     


Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly 
            580                 585                 590         


Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly 
        595                 600                 605             


Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln 
    610                 615                 620                 


Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu 
625                 630                 635                 640 


Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe 
                645                 650                 655     


Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile 
            660                 665                 670         


Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr 
        675                 680                 685             


Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile 
    690                 695                 700         


<210>  30
<211>  2322
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gln Ser Gly Pro Arg Pro Pro Leu Pro Ala Pro Gly Leu Ala Leu 
1               5                   10                  15      


Ala Leu Thr Leu Thr Met Leu Ala Arg Leu Ala Ser Ala Ala Ser Phe 
            20                  25                  30          


Phe Gly Glu Asn His Leu Glu Val Pro Val Ala Thr Ala Leu Thr Asp 
        35                  40                  45              


Ile Asp Leu Gln Leu Gln Phe Ser Thr Ser Gln Pro Glu Ala Leu Leu 
    50                  55                  60                  


Leu Leu Ala Ala Gly Pro Ala Asp His Leu Leu Leu Gln Leu Tyr Ser 
65                  70                  75                  80  


Gly Arg Leu Gln Val Arg Leu Val Leu Gly Gln Glu Glu Leu Arg Leu 
                85                  90                  95      


Gln Thr Pro Ala Glu Thr Leu Leu Ser Asp Ser Ile Pro His Thr Val 
            100                 105                 110         


Val Leu Thr Val Val Glu Gly Trp Ala Thr Leu Ser Val Asp Gly Phe 
        115                 120                 125             


Leu Asn Ala Ser Ser Ala Val Pro Gly Ala Pro Leu Glu Val Pro Tyr 
    130                 135                 140                 


Gly Leu Phe Val Gly Gly Thr Gly Thr Leu Gly Leu Pro Tyr Leu Arg 
145                 150                 155                 160 


Gly Thr Ser Arg Pro Leu Arg Gly Cys Leu His Ala Ala Thr Leu Asn 
                165                 170                 175     


Gly Arg Ser Leu Leu Arg Pro Leu Thr Pro Asp Val His Glu Gly Cys 
            180                 185                 190         


Ala Glu Glu Phe Ser Ala Ser Asp Asp Val Ala Leu Gly Phe Ser Gly 
        195                 200                 205             


Pro His Ser Leu Ala Ala Phe Pro Ala Trp Gly Thr Gln Asp Glu Gly 
    210                 215                 220                 


Thr Leu Glu Phe Thr Leu Thr Thr Gln Ser Arg Gln Ala Pro Leu Ala 
225                 230                 235                 240 


Phe Gln Ala Gly Gly Arg Arg Gly Asp Phe Ile Tyr Val Asp Ile Phe 
                245                 250                 255     


Glu Gly His Leu Arg Ala Val Val Glu Lys Gly Gln Gly Thr Val Leu 
            260                 265                 270         


Leu His Asn Ser Val Pro Val Ala Asp Gly Gln Pro His Glu Val Ser 
        275                 280                 285             


Val His Ile Asn Ala His Arg Leu Glu Ile Ser Val Asp Gln Tyr Pro 
    290                 295                 300                 


Thr His Thr Ser Asn Arg Gly Val Leu Ser Tyr Leu Glu Pro Arg Gly 
305                 310                 315                 320 


Ser Leu Leu Leu Gly Gly Leu Asp Ala Glu Ala Ser Arg His Leu Gln 
                325                 330                 335     


Glu His Arg Leu Gly Leu Thr Pro Glu Ala Thr Asn Ala Ser Leu Leu 
            340                 345                 350         


Gly Cys Met Glu Asp Leu Ser Val Asn Gly Gln Arg Arg Gly Leu Arg 
        355                 360                 365             


Glu Ala Leu Leu Thr Arg Asn Met Ala Ala Gly Cys Arg Leu Glu Glu 
    370                 375                 380                 


Glu Glu Tyr Glu Asp Asp Ala Tyr Gly His Tyr Glu Ala Phe Ser Thr 
385                 390                 395                 400 


Leu Ala Pro Glu Ala Trp Pro Ala Met Glu Leu Pro Glu Pro Cys Val 
                405                 410                 415     


Pro Glu Pro Gly Leu Pro Pro Val Phe Ala Asn Phe Thr Gln Leu Leu 
            420                 425                 430         


Thr Ile Ser Pro Leu Val Val Ala Glu Gly Gly Thr Ala Trp Leu Glu 
        435                 440                 445             


Trp Arg His Val Gln Pro Thr Leu Asp Leu Met Glu Ala Glu Leu Arg 
    450                 455                 460                 


Lys Ser Gln Val Leu Phe Ser Val Thr Arg Gly Ala Arg His Gly Glu 
465                 470                 475                 480 


Leu Glu Leu Asp Ile Pro Gly Ala Gln Ala Arg Lys Met Phe Thr Leu 
                485                 490                 495     


Leu Asp Val Val Asn Arg Lys Ala Arg Phe Ile His Asp Gly Ser Glu 
            500                 505                 510         


Asp Thr Ser Asp Gln Leu Val Leu Glu Val Ser Val Thr Ala Arg Val 
        515                 520                 525             


Pro Met Pro Ser Cys Leu Arg Arg Gly Gln Thr Tyr Leu Leu Pro Ile 
    530                 535                 540                 


Gln Val Asn Pro Val Asn Asp Pro Pro His Ile Ile Phe Pro His Gly 
545                 550                 555                 560 


Ser Leu Met Val Ile Leu Glu His Thr Gln Lys Pro Leu Gly Pro Glu 
                565                 570                 575     


Val Phe Gln Ala Tyr Asp Pro Asp Ser Ala Cys Glu Gly Leu Thr Phe 
            580                 585                 590         


Gln Val Leu Gly Thr Ser Ser Gly Leu Pro Val Glu Arg Arg Asp Gln 
        595                 600                 605             


Pro Gly Glu Pro Ala Thr Glu Phe Ser Cys Arg Glu Leu Glu Ala Gly 
    610                 615                 620                 


Ser Leu Val Tyr Val His Arg Gly Gly Pro Ala Gln Asp Leu Thr Phe 
625                 630                 635                 640 


Arg Val Ser Asp Gly Leu Gln Ala Ser Pro Pro Ala Thr Leu Lys Val 
                645                 650                 655     


Val Ala Ile Arg Pro Ala Ile Gln Ile His Arg Ser Thr Gly Leu Arg 
            660                 665                 670         


Leu Ala Gln Gly Ser Ala Met Pro Ile Leu Pro Ala Asn Leu Ser Val 
        675                 680                 685             


Glu Thr Asn Ala Val Gly Gln Asp Val Ser Val Leu Phe Arg Val Thr 
    690                 695                 700                 


Gly Ala Leu Gln Phe Gly Glu Leu Gln Lys Gln Gly Ala Gly Gly Val 
705                 710                 715                 720 


Glu Gly Ala Glu Trp Trp Ala Thr Gln Ala Phe His Gln Arg Asp Val 
                725                 730                 735     


Glu Gln Gly Arg Val Arg Tyr Leu Ser Thr Asp Pro Gln His His Ala 
            740                 745                 750         


Tyr Asp Thr Val Glu Asn Leu Ala Leu Glu Val Gln Val Gly Gln Glu 
        755                 760                 765             


Ile Leu Ser Asn Leu Ser Phe Pro Val Thr Ile Gln Arg Ala Thr Val 
    770                 775                 780                 


Trp Met Leu Arg Leu Glu Pro Leu His Thr Gln Asn Thr Gln Gln Glu 
785                 790                 795                 800 


Thr Leu Thr Thr Ala His Leu Glu Ala Thr Leu Glu Glu Ala Gly Pro 
                805                 810                 815     


Ser Pro Pro Thr Phe His Tyr Glu Val Val Gln Ala Pro Arg Lys Gly 
            820                 825                 830         


Asn Leu Gln Leu Gln Gly Thr Arg Leu Ser Asp Gly Gln Gly Phe Thr 
        835                 840                 845             


Gln Asp Asp Ile Gln Ala Gly Arg Val Thr Tyr Gly Ala Thr Ala Arg 
    850                 855                 860                 


Ala Ser Glu Ala Val Glu Asp Thr Phe Arg Phe Arg Val Thr Ala Pro 
865                 870                 875                 880 


Pro Tyr Phe Ser Pro Leu Tyr Thr Phe Pro Ile His Ile Gly Gly Asp 
                885                 890                 895     


Pro Asp Ala Pro Val Leu Thr Asn Val Leu Leu Val Val Pro Glu Gly 
            900                 905                 910         


Gly Glu Gly Val Leu Ser Ala Asp His Leu Phe Val Lys Ser Leu Asn 
        915                 920                 925             


Ser Ala Ser Tyr Leu Tyr Glu Val Met Glu Arg Pro Arg His Gly Arg 
    930                 935                 940                 


Leu Ala Trp Arg Gly Thr Gln Asp Lys Thr Thr Met Val Thr Ser Phe 
945                 950                 955                 960 


Thr Asn Glu Asp Leu Leu Arg Gly Arg Leu Val Tyr Gln His Asp Asp 
                965                 970                 975     


Ser Glu Thr Thr Glu Asp Asp Ile Pro Phe Val Ala Thr Arg Gln Gly 
            980                 985                 990         


Glu Ser Ser Gly Asp Met Ala Trp  Glu Glu Val Arg Gly  Val Phe Arg 
        995                 1000                 1005             


Val Ala  Ile Gln Pro Val Asn  Asp His Ala Pro Val  Gln Thr Ile 
    1010                 1015                 1020             


Ser Arg  Ile Phe His Val Ala  Arg Gly Gly Arg Arg  Leu Leu Thr 
    1025                 1030                 1035             


Thr Asp  Asp Val Ala Phe Ser  Asp Ala Asp Ser Gly  Phe Ala Asp 
    1040                 1045                 1050             


Ala Gln  Leu Val Leu Thr Arg  Lys Asp Leu Leu Phe  Gly Ser Ile 
    1055                 1060                 1065             


Val Ala  Val Asp Glu Pro Thr  Arg Pro Ile Tyr Arg  Phe Thr Gln 
    1070                 1075                 1080             


Glu Asp  Leu Arg Lys Arg Arg  Val Leu Phe Val His  Ser Gly Ala 
    1085                 1090                 1095             


Asp Arg  Gly Trp Ile Gln Leu  Gln Val Ser Asp Gly  Gln His Gln 
    1100                 1105                 1110             


Ala Thr  Ala Leu Leu Glu Val  Gln Ala Ser Glu Pro  Tyr Leu Arg 
    1115                 1120                 1125             


Val Ala  Asn Gly Ser Ser Leu  Val Val Pro Gln Gly  Gly Gln Gly 
    1130                 1135                 1140             


Thr Ile  Asp Thr Ala Val Leu  His Leu Asp Thr Asn  Leu Asp Ile 
    1145                 1150                 1155             


Arg Ser  Gly Asp Glu Val His  Tyr His Val Thr Ala  Gly Pro Arg 
    1160                 1165                 1170             


Trp Gly  Gln Leu Val Arg Ala  Gly Gln Pro Ala Thr  Ala Phe Ser 
    1175                 1180                 1185             


Gln Gln  Asp Leu Leu Asp Gly  Ala Val Leu Tyr Ser  His Asn Gly 
    1190                 1195                 1200             


Ser Leu  Ser Pro Arg Asp Thr  Met Ala Phe Ser Val  Glu Ala Gly 
    1205                 1210                 1215             


Pro Val  His Thr Asp Ala Thr  Leu Gln Val Thr Ile  Ala Leu Glu 
    1220                 1225                 1230             


Gly Pro  Leu Ala Pro Leu Lys  Leu Val Arg His Lys  Lys Ile Tyr 
    1235                 1240                 1245             


Val Phe  Gln Gly Glu Ala Ala  Glu Ile Arg Arg Asp  Gln Leu Glu 
    1250                 1255                 1260             


Ala Ala  Gln Glu Ala Val Pro  Pro Ala Asp Ile Val  Phe Ser Val 
    1265                 1270                 1275             


Lys Ser  Pro Pro Ser Ala Gly  Tyr Leu Val Met Val  Ser Arg Gly 
    1280                 1285                 1290             


Ala Leu  Ala Asp Glu Pro Pro  Ser Leu Asp Pro Val  Gln Ser Phe 
    1295                 1300                 1305             


Ser Gln  Glu Ala Val Asp Thr  Gly Arg Val Leu Tyr  Leu His Ser 
    1310                 1315                 1320             


Arg Pro  Glu Ala Trp Ser Asp  Ala Phe Ser Leu Asp  Val Ala Ser 
    1325                 1330                 1335             


Gly Leu  Gly Ala Pro Leu Glu  Gly Val Leu Val Glu  Leu Glu Val 
    1340                 1345                 1350             


Leu Pro  Ala Ala Ile Pro Leu  Glu Ala Gln Asn Phe  Ser Val Pro 
    1355                 1360                 1365             


Glu Gly  Gly Ser Leu Thr Leu  Ala Pro Pro Leu Leu  Arg Val Ser 
    1370                 1375                 1380             


Gly Pro  Tyr Phe Pro Thr Leu  Leu Gly Leu Ser Leu  Gln Val Leu 
    1385                 1390                 1395             


Glu Pro  Pro Gln His Gly Ala  Leu Gln Lys Glu Asp  Gly Pro Gln 
    1400                 1405                 1410             


Ala Arg  Thr Leu Ser Ala Phe  Ser Trp Arg Met Val  Glu Glu Gln 
    1415                 1420                 1425             


Leu Ile  Arg Tyr Val His Asp  Gly Ser Glu Thr Leu  Thr Asp Ser 
    1430                 1435                 1440             


Phe Val  Leu Met Ala Asn Ala  Ser Glu Met Asp Arg  Gln Ser His 
    1445                 1450                 1455             


Pro Val  Ala Phe Thr Val Thr  Val Leu Pro Val Asn  Asp Gln Pro 
    1460                 1465                 1470             


Pro Ile  Leu Thr Thr Asn Thr  Gly Leu Gln Met Trp  Glu Gly Ala 
    1475                 1480                 1485             


Thr Ala  Pro Ile Pro Ala Glu  Ala Leu Arg Ser Thr  Asp Gly Asp 
    1490                 1495                 1500             


Ser Gly  Ser Glu Asp Leu Val  Tyr Thr Ile Glu Gln  Pro Ser Asn 
    1505                 1510                 1515             


Gly Arg  Val Val Leu Arg Gly  Ala Pro Gly Thr Glu  Val Arg Ser 
    1520                 1525                 1530             


Phe Thr  Gln Ala Gln Leu Asp  Gly Gly Leu Val Leu  Phe Ser His 
    1535                 1540                 1545             


Arg Gly  Thr Leu Asp Gly Gly  Phe Arg Phe Arg Leu  Ser Asp Gly 
    1550                 1555                 1560             


Glu His  Thr Ser Pro Gly His  Phe Phe Arg Val Thr  Ala Gln Lys 
    1565                 1570                 1575             


Gln Val  Leu Leu Ser Leu Lys  Gly Ser Gln Thr Leu  Thr Val Cys 
    1580                 1585                 1590             


Pro Gly  Ser Val Gln Pro Leu  Ser Ser Gln Thr Leu  Arg Ala Ser 
    1595                 1600                 1605             


Ser Ser  Ala Gly Thr Asp Pro  Gln Leu Leu Leu Tyr  Arg Val Val 
    1610                 1615                 1620             


Arg Gly  Pro Gln Leu Gly Arg  Leu Phe His Ala Gln  Gln Asp Ser 
    1625                 1630                 1635             


Thr Gly  Glu Ala Leu Val Asn  Phe Thr Gln Ala Glu  Val Tyr Ala 
    1640                 1645                 1650             


Gly Asn  Ile Leu Tyr Glu His  Glu Met Pro Pro Glu  Pro Phe Trp 
    1655                 1660                 1665             


Glu Ala  His Asp Thr Leu Glu  Leu Gln Leu Ser Ser  Pro Pro Ala 
    1670                 1675                 1680             


Arg Asp  Val Ala Ala Thr Leu  Ala Val Ala Val Ser  Phe Glu Ala 
    1685                 1690                 1695             


Ala Cys  Pro Gln Arg Pro Ser  His Leu Trp Lys Asn  Lys Gly Leu 
    1700                 1705                 1710             


Trp Val  Pro Glu Gly Gln Arg  Ala Arg Ile Thr Val  Ala Ala Leu 
    1715                 1720                 1725             


Asp Ala  Ser Asn Leu Leu Ala  Ser Val Pro Ser Pro  Gln Arg Ser 
    1730                 1735                 1740             


Glu His  Asp Val Leu Phe Gln  Val Thr Gln Phe Pro  Ser Arg Gly 
    1745                 1750                 1755             


Gln Leu  Leu Val Ser Glu Glu  Pro Leu His Ala Gly  Gln Pro His 
    1760                 1765                 1770             


Phe Leu  Gln Ser Gln Leu Ala  Ala Gly Gln Leu Val  Tyr Ala His 
    1775                 1780                 1785             


Gly Gly  Gly Gly Thr Gln Gln  Asp Gly Phe His Phe  Arg Ala His 
    1790                 1795                 1800             


Leu Gln  Gly Pro Ala Gly Ala  Ser Val Ala Gly Pro  Gln Thr Ser 
    1805                 1810                 1815             


Glu Ala  Phe Ala Ile Thr Val  Arg Asp Val Asn Glu  Arg Pro Pro 
    1820                 1825                 1830             


Gln Pro  Gln Ala Ser Val Pro  Leu Arg Leu Thr Arg  Gly Ser Arg 
    1835                 1840                 1845             


Ala Pro  Ile Ser Arg Ala Gln  Leu Ser Val Val Asp  Pro Asp Ser 
    1850                 1855                 1860             


Ala Pro  Gly Glu Ile Glu Tyr  Glu Val Gln Arg Ala  Pro His Asn 
    1865                 1870                 1875             


Gly Phe  Leu Ser Leu Val Gly  Gly Gly Leu Gly Pro  Val Thr Arg 
    1880                 1885                 1890             


Phe Thr  Gln Ala Asp Val Asp  Ser Gly Arg Leu Ala  Phe Val Ala 
    1895                 1900                 1905             


Asn Gly  Ser Ser Val Ala Gly  Ile Phe Gln Leu Ser  Met Ser Asp 
    1910                 1915                 1920             


Gly Ala  Ser Pro Pro Leu Pro  Met Ser Leu Ala Val  Asp Ile Leu 
    1925                 1930                 1935             


Pro Ser  Ala Ile Glu Val Gln  Leu Arg Ala Pro Leu  Glu Val Pro 
    1940                 1945                 1950             


Gln Ala  Leu Gly Arg Ser Ser  Leu Ser Gln Gln Gln  Leu Arg Val 
    1955                 1960                 1965             


Val Ser  Asp Arg Glu Glu Pro  Glu Ala Ala Tyr Arg  Leu Ile Gln 
    1970                 1975                 1980             


Gly Pro  Gln Tyr Gly His Leu  Leu Val Gly Gly Arg  Pro Thr Ser 
    1985                 1990                 1995             


Ala Phe  Ser Gln Phe Gln Ile  Asp Gln Gly Glu Val  Val Phe Ala 
    2000                 2005                 2010             


Phe Thr  Asn Phe Ser Ser Ser  His Asp His Phe Arg  Val Leu Ala 
    2015                 2020                 2025             


Leu Ala  Arg Gly Val Asn Ala  Ser Ala Val Val Asn  Val Thr Val 
    2030                 2035                 2040             


Arg Ala  Leu Leu His Val Trp  Ala Gly Gly Pro Trp  Pro Gln Gly 
    2045                 2050                 2055             


Ala Thr  Leu Arg Leu Asp Pro  Thr Val Leu Asp Ala  Gly Glu Leu 
    2060                 2065                 2070             


Ala Asn  Arg Thr Gly Ser Val  Pro Arg Phe Arg Leu  Leu Glu Gly 
    2075                 2080                 2085             


Pro Arg  His Gly Arg Val Val  Arg Val Pro Arg Ala  Arg Thr Glu 
    2090                 2095                 2100             


Pro Gly  Gly Ser Gln Leu Val  Glu Gln Phe Thr Gln  Gln Asp Leu 
    2105                 2110                 2115             


Glu Asp  Gly Arg Leu Gly Leu  Glu Val Gly Arg Pro  Glu Gly Arg 
    2120                 2125                 2130             


Ala Pro  Gly Pro Ala Gly Asp  Ser Leu Thr Leu Glu  Leu Trp Ala 
    2135                 2140                 2145             


Gln Gly  Val Pro Pro Ala Val  Ala Ser Leu Asp Phe  Ala Thr Glu 
    2150                 2155                 2160             


Pro Tyr  Asn Ala Ala Arg Pro  Tyr Ser Val Ala Leu  Leu Ser Val 
    2165                 2170                 2175             


Pro Glu  Ala Ala Arg Thr Glu  Ala Gly Lys Pro Glu  Ser Ser Thr 
    2180                 2185                 2190             


Pro Thr  Gly Glu Pro Gly Pro  Met Ala Ser Ser Pro  Glu Pro Ala 
    2195                 2200                 2205             


Val Ala  Lys Gly Gly Phe Leu  Ser Phe Leu Glu Ala  Asn Met Phe 
    2210                 2215                 2220             


Ser Val  Ile Ile Pro Met Cys  Leu Val Leu Leu Leu  Leu Ala Leu 
    2225                 2230                 2235             


Ile Leu  Pro Leu Leu Phe Tyr  Leu Arg Lys Arg Asn  Lys Thr Gly 
    2240                 2245                 2250             


Lys His  Asp Val Gln Val Leu  Thr Ala Lys Pro Arg  Asn Gly Leu 
    2255                 2260                 2265             


Ala Gly  Asp Thr Glu Thr Phe  Arg Lys Val Glu Pro  Gly Gln Ala 
    2270                 2275                 2280             


Ile Pro  Leu Thr Ala Val Pro  Gly Gln Gly Pro Pro  Pro Gly Gly 
    2285                 2290                 2295             


Gln Pro  Asp Pro Glu Leu Leu  Gln Phe Cys Arg Thr  Pro Asn Pro 
    2300                 2305                 2310             


Ala Leu  Lys Asn Gly Gln Tyr  Trp Val 
    2315                 2320         


<210>  31
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


<210>  32
<211>  556
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe Phe Lys Val 
                325                 330                 335     


Thr Pro Pro Pro Gly Ser Gly Pro Gln Asn Gln Tyr Gly Asn Val Leu 
            340                 345                 350         


Ser Leu Pro Thr Pro Thr Ser Gly Leu Gly Arg Ala Gln Arg Trp Ala 
        355                 360                 365             


Ala Gly Leu Gly Gly Thr Ala Pro Ser Tyr Gly Asn Pro Ser Ser Asp 
    370                 375                 380                 


Val Gln Ala Asp Gly Ala Leu Gly Ser Arg Ser Pro Pro Gly Val Gly 
385                 390                 395                 400 


Pro Glu Glu Glu Glu Gly Glu Gly Tyr Glu Glu Pro Asp Ser Glu Glu 
                405                 410                 415     


Asp Ser Glu Phe Tyr Glu Asn Asp Ser Asn Leu Gly Gln Asp Gln Leu 
            420                 425                 430         


Ser Gln Asp Gly Ser Gly Tyr Glu Asn Pro Glu Asp Glu Pro Leu Gly 
        435                 440                 445             


Pro Glu Asp Glu Asp Ser Phe Ser Asn Ala Glu Ser Tyr Glu Asn Glu 
    450                 455                 460                 


Asp Glu Glu Leu Thr Gln Pro Val Ala Arg Thr Met Asp Phe Leu Ser 
465                 470                 475                 480 


Pro His Gly Ser Ala Trp Asp Pro Ser Arg Glu Ala Thr Ser Leu Gly 
                485                 490                 495     


Ser Gln Ser Tyr Glu Asp Met Arg Gly Ile Leu Tyr Ala Ala Pro Gln 
            500                 505                 510         


Leu Arg Ser Ile Arg Gly Gln Pro Gly Pro Asn His Glu Glu Asp Ala 
        515                 520                 525             


Asp Ser Tyr Glu Asn Met Asp Asn Pro Asp Gly Pro Asp Pro Ala Trp 
    530                 535                 540                 


Gly Gly Gly Gly Arg Met Gly Thr Trp Ser Thr Arg 
545                 550                 555     


<210>  33
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  34
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  35
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  36
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  37
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  38
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Arg Val Gln Pro Leu Glu Glu Asn Val Gly Asn Ala Ala Arg 
1               5                   10                  15      


Pro Arg Phe Glu Arg Asn Lys Leu Leu Leu Val Ala Ser Val Ile Gln 
            20                  25                  30          


Gly Leu Gly Leu Leu Leu Cys Phe Thr Tyr Ile Cys Leu His Phe Ser 
        35                  40                  45              


Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser Ile Lys Val 
    50                  55                  60                  


Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu Thr Ser Gln 
65                  70                  75                  80  


Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val Ile Ile Asn 
                85                  90                  95      


Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe Ser Gln Glu 
            100                 105                 110         


Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro Leu Phe Gln 
        115                 120                 125             


Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala Ser Leu Thr 
    130                 135                 140                 


Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn Thr Ser Leu 
145                 150                 155                 160 


Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile His Gln Asn 
                165                 170                 175     


Pro Gly Glu Phe Cys Val Leu 
            180             


<210>  39
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  40
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  41
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Glu Glu Gly Ser Gly Cys Ser Val Arg Arg Arg Pro Tyr Gly 
1               5                   10                  15      


Cys Val Leu Arg Ala Ala Leu Val Pro Leu Val Ala Gly Leu Val Ile 
            20                  25                  30          


Cys Leu Val Val Cys Ile Gln Arg Phe Ala Gln Ala Gln Gln Gln Leu 
        35                  40                  45              


Pro Leu Glu Ser Leu Gly Trp Asp Val Ala Glu Leu Gln Leu Asn His 
    50                  55                  60                  


Thr Gly Pro Gln Gln Asp Pro Arg Leu Tyr Trp Gln Gly Gly Pro Ala 
65                  70                  75                  80  


Leu Gly Arg Ser Phe Leu His Gly Pro Glu Leu Asp Lys Gly Gln Leu 
                85                  90                  95      


Arg Ile His Arg Asp Gly Ile Tyr Met Val His Ile Gln Val Thr Leu 
            100                 105                 110         


Ala Ile Cys Ser Ser Thr Thr Ala Ser Arg His His Pro Thr Thr Leu 
        115                 120                 125             


Ala Val Gly Ile Cys Ser Pro Ala Ser Arg Ser Ile Ser Leu Leu Arg 
    130                 135                 140                 


Leu Ser Phe His Gln Gly Cys Thr Ile Ala Ser Gln Arg Leu Thr Pro 
145                 150                 155                 160 


Leu Ala Arg Gly Asp Thr Leu Cys Thr Asn Leu Thr Gly Thr Leu Leu 
                165                 170                 175     


Pro Ser Arg Asn Thr Asp Glu Thr Phe Phe Gly Val Gln Trp Val Arg 
            180                 185                 190         


Pro 
    


<210>  42
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asp Pro Gly Leu Gln Gln Ala Leu Asn Gly Met Ala Pro Pro Gly 
1               5                   10                  15      


Asp Thr Ala Met His Val Pro Ala Gly Ser Val Ala Ser His Leu Gly 
            20                  25                  30          


Thr Thr Ser Arg Ser Tyr Phe Tyr Leu Thr Thr Ala Thr Leu Ala Leu 
        35                  40                  45              


Cys Leu Val Phe Thr Val Ala Thr Ile Met Val Leu Val Val Gln Arg 
    50                  55                  60                  


Thr Asp Ser Ile Pro Asn Ser Pro Asp Asn Val Pro Leu Lys Gly Gly 
65                  70                  75                  80  


Asn Cys Ser Glu Asp Leu Leu Cys Ile Leu Lys Arg Ala Pro Phe Lys 
                85                  90                  95      


Lys Ser Trp Ala Tyr Leu Gln Val Ala Lys His Leu Asn Lys Thr Lys 
            100                 105                 110         


Leu Ser Trp Asn Lys Asp Gly Ile Leu His Gly Val Arg Tyr Gln Asp 
        115                 120                 125             


Gly Asn Leu Val Ile Gln Phe Pro Gly Leu Tyr Phe Ile Ile Cys Gln 
    130                 135                 140                 


Leu Gln Phe Leu Val Gln Cys Pro Asn Asn Ser Val Asp Leu Lys Leu 
145                 150                 155                 160 


Glu Leu Leu Ile Asn Lys His Ile Lys Lys Gln Ala Leu Val Thr Val 
                165                 170                 175     


Cys Glu Ser Gly Met Gln Thr Lys His Val Tyr Gln Asn Leu Ser Gln 
            180                 185                 190         


Phe Leu Leu Asp Tyr Leu Gln Val Asn Thr Thr Ile Ser Val Asn Val 
        195                 200                 205             


Asp Thr Phe Gln Tyr Ile Asp Thr Ser Thr Phe Pro Leu Glu Asn Val 
    210                 215                 220                 


Leu Ser Ile Phe Leu Tyr Ser Asn Ser Asp 
225                 230                 


<210>  43
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  44
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  45
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Arg Arg Ala Ser Arg Asp Tyr Thr Lys Tyr Leu Arg Gly Ser Glu 
1               5                   10                  15      


Glu Met Gly Gly Gly Pro Gly Ala Pro His Glu Gly Pro Leu His Ala 
            20                  25                  30          


Pro Pro Pro Pro Ala Pro His Gln Pro Pro Ala Ala Ser Arg Ser Met 
        35                  40                  45              


Phe Val Ala Leu Leu Gly Leu Gly Leu Gly Gln Val Val Cys Ser Val 
    50                  55                  60                  


Ala Leu Phe Phe Tyr Phe Arg Ala Gln Met Asp Pro Asn Arg Ile Ser 
65                  70                  75                  80  


Glu Asp Gly Thr His Cys Ile Tyr Arg Ile Leu Arg Leu His Glu Asn 
                85                  90                  95      


Ala Asp Phe Gln Asp Thr Thr Leu Glu Ser Gln Asp Thr Lys Leu Ile 
            100                 105                 110         


Pro Asp Ser Cys Arg Arg Ile Lys Gln Ala Phe Gln Gly Ala Val Gln 
        115                 120                 125             


Lys Glu Leu Gln His Ile Val Gly Ser Gln His Ile Arg Ala Glu Lys 
    130                 135                 140                 


Ala Met Val Asp Gly Ser Trp Leu Asp Leu Ala Lys Arg Ser Lys Leu 
145                 150                 155                 160 


Glu Ala Gln Pro Phe Ala His Leu Thr Ile Asn Ala Thr Asp Ile Pro 
                165                 170                 175     


Ser Gly Ser His Lys Val Ser Leu Ser Ser Trp Tyr His Asp Arg Gly 
            180                 185                 190         


Trp Ala Lys Ile Ser Asn Met Thr Phe Ser Asn Gly Lys Leu Ile Val 
        195                 200                 205             


Asn Gln Asp Gly Phe Tyr Tyr Leu Tyr Ala Asn Ile Cys Phe Arg His 
    210                 215                 220                 


His Glu Thr Ser Gly Asp Leu Ala Thr Glu Tyr Leu Gln Leu Met Val 
225                 230                 235                 240 


Tyr Val Thr Lys Thr Ser Ile Lys Ile Pro Ser Ser His Thr Leu Met 
                245                 250                 255     


Lys Gly Gly Ser Thr Lys Tyr Trp Ser Gly Asn Ser Glu Phe His Phe 
            260                 265                 270         


Tyr Ser Ile Asn Val Gly Gly Phe Phe Lys Leu Arg Ser Gly Glu Glu 
        275                 280                 285             


Ile Ser Ile Glu Val Ser Asn Pro Ser Leu Leu Asp Pro Asp Gln Asp 
    290                 295                 300                 


Ala Thr Tyr Phe Gly Ala Phe Lys Val Arg Asp Ile Asp 
305                 310                 315         


<210>  46
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Ala Arg Arg Ser Gln Arg Arg Arg Gly Arg Arg Gly Glu Pro 
1               5                   10                  15      


Gly Thr Ala Leu Leu Val Pro Leu Ala Leu Gly Leu Gly Leu Ala Leu 
            20                  25                  30          


Ala Cys Leu Gly Leu Leu Leu Ala Val Val Ser Leu Gly Ser Arg Ala 
        35                  40                  45              


Ser Leu Ser Ala Gln Glu Pro Ala Gln Glu Glu Leu Val Ala Glu Glu 
    50                  55                  60                  


Asp Gln Asp Pro Ser Glu Leu Asn Pro Gln Thr Glu Glu Ser Gln Asp 
65                  70                  75                  80  


Pro Ala Pro Phe Leu Asn Arg Leu Val Arg Pro Arg Arg Ser Ala Pro 
                85                  90                  95      


Lys Gly Arg Lys Thr Arg Ala Arg Arg Ala Ile Ala Ala His Tyr Glu 
            100                 105                 110         


Val His Pro Arg Pro Gly Gln Asp Gly Ala Gln Ala Gly Val Asp Gly 
        115                 120                 125             


Thr Val Ser Gly Trp Glu Glu Ala Arg Ile Asn Ser Ser Ser Pro Leu 
    130                 135                 140                 


Arg Tyr Asn Arg Gln Ile Gly Glu Phe Ile Val Thr Arg Ala Gly Leu 
145                 150                 155                 160 


Tyr Tyr Leu Tyr Cys Gln Val His Phe Asp Glu Gly Lys Ala Val Tyr 
                165                 170                 175     


Leu Lys Leu Asp Leu Leu Val Asp Gly Val Leu Ala Leu Arg Cys Leu 
            180                 185                 190         


Glu Glu Phe Ser Ala Thr Ala Ala Ser Ser Leu Gly Pro Gln Leu Arg 
        195                 200                 205             


Leu Cys Gln Val Ser Gly Leu Leu Ala Leu Arg Pro Gly Ser Ser Leu 
    210                 215                 220                 


Arg Ile Arg Thr Leu Pro Trp Ala His Leu Lys Ala Ala Pro Phe Leu 
225                 230                 235                 240 


Thr Tyr Phe Gly Leu Phe Gln Val His 
                245                 


<210>  47
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Pro Ala Ser Ser Pro Phe Leu Leu Ala Pro Lys Gly Pro Pro Gly 
1               5                   10                  15      


Asn Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp 
            20                  25                  30          


Leu Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu 
        35                  40                  45              


Leu Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg 
    50                  55                  60                  


Leu Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp 
65                  70                  75                  80  


Gln Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn 
                85                  90                  95      


Gly Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys 
            100                 105                 110         


Lys Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
        115                 120                 125             


Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg 
    130                 135                 140                 


Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala 
145                 150                 155                 160 


Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe 
                165                 170                 175     


Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr 
            180                 185                 190         


Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr 
        195                 200                 205             


Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile 
    210                 215                 220                 


Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro 
225                 230                 235                 240 


His Gly Thr Phe Leu Gly Phe Val Lys Leu 
                245                 250 


<210>  48
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  49
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  50
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210>  51
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Thr Leu His Pro Ser Pro Ile Thr Cys Glu Phe Leu Phe Ser Thr 
1               5                   10                  15      


Ala Leu Ile Ser Pro Lys Met Cys Leu Ser His Leu Glu Asn Met Pro 
            20                  25                  30          


Leu Ser His Ser Arg Thr Gln Gly Ala Gln Arg Ser Ser Trp Lys Leu 
        35                  40                  45              


Trp Leu Phe Cys Ser Ile Val Met Leu Leu Phe Leu Cys Ser Phe Ser 
    50                  55                  60                  


Trp Leu Ile Phe Ile Phe Leu Gln Leu Glu Thr Ala Lys Glu Pro Cys 
65                  70                  75                  80  


Met Ala Lys Phe Gly Pro Leu Pro Ser Lys Trp Gln Met Ala Ser Ser 
                85                  90                  95      


Glu Pro Pro Cys Val Asn Lys Val Ser Asp Trp Lys Leu Glu Ile Leu 
            100                 105                 110         


Gln Asn Gly Leu Tyr Leu Ile Tyr Gly Gln Val Ala Pro Asn Ala Asn 
        115                 120                 125             


Tyr Asn Asp Val Ala Pro Phe Glu Val Arg Leu Tyr Lys Asn Lys Asp 
    130                 135                 140                 


Met Ile Gln Thr Leu Thr Asn Lys Ser Lys Ile Gln Asn Val Gly Gly 
145                 150                 155                 160 


Thr Tyr Glu Leu His Val Gly Asp Thr Ile Asp Leu Ile Phe Asn Ser 
                165                 170                 175     


Glu His Gln Val Leu Lys Asn Asn Thr Tyr Trp Gly Ile Ile Leu Leu 
            180                 185                 190         


Ala Asn Pro Gln Phe Ile Ser 
        195                 


<210>  52
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Gly Tyr Pro Glu Val Glu Arg Arg Glu Leu Leu Pro Ala Ala Ala 
1               5                   10                  15      


Pro Arg Glu Arg Gly Ser Gln Gly Cys Gly Cys Gly Gly Ala Pro Ala 
            20                  25                  30          


Arg Ala Gly Glu Gly Asn Ser Cys Leu Leu Phe Leu Gly Phe Phe Gly 
        35                  40                  45              


Leu Ser Leu Ala Leu His Leu Leu Thr Leu Cys Cys Tyr Leu Glu Leu 
    50                  55                  60                  


Arg Ser Glu Leu Arg Arg Glu Arg Gly Ala Glu Ser Arg Leu Gly Gly 
65                  70                  75                  80  


Ser Gly Thr Pro Gly Thr Ser Gly Thr Leu Ser Ser Leu Gly Gly Leu 
                85                  90                  95      


Asp Pro Asp Ser Pro Ile Thr Ser His Leu Gly Gln Pro Ser Pro Lys 
            100                 105                 110         


Gln Gln Pro Leu Glu Pro Gly Glu Ala Ala Leu His Ser Asp Ser Gln 
        115                 120                 125             


Asp Gly His Gln Met Ala Leu Leu Asn Phe Phe Phe Pro Asp Glu Lys 
    130                 135                 140                 


Pro Tyr Ser Glu Glu Glu Ser Arg Arg Val Arg Arg Asn Lys Arg Ser 
145                 150                 155                 160 


Lys Ser Asn Glu Gly Ala Asp Gly Pro Val Lys Asn Lys Lys Lys Gly 
                165                 170                 175     


Lys Lys Ala Gly Pro Pro Gly Pro Asn Gly Pro Pro Gly Pro Pro Gly 
            180                 185                 190         


Pro Pro Gly Pro Gln Gly Pro Pro Gly Ile Pro Gly Ile Pro Gly Ile 
        195                 200                 205             


Pro Gly Thr Thr Val Met Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly 
    210                 215                 220                 


Pro Gln Gly Pro Pro Gly Leu Gln Gly Pro Ser Gly Ala Ala Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Arg Glu Asn Gln Pro Ala Val Val His Leu Gln Gly Gln 
                245                 250                 255     


Gly Ser Ala Ile Gln Val Lys Asn Asp Leu Ser Gly Gly Val Leu Asn 
            260                 265                 270         


Asp Trp Ser Arg Ile Thr Met Asn Pro Lys Val Phe Lys Leu His Pro 
        275                 280                 285             


Arg Ser Gly Glu Leu Glu Val Leu Val Asp Gly Thr Tyr Phe Ile Tyr 
    290                 295                 300                 


Ser Gln Val Glu Val Tyr Tyr Ile Asn Phe Thr Asp Phe Ala Ser Tyr 
305                 310                 315                 320 


Glu Val Val Val Asp Glu Lys Pro Phe Leu Gln Cys Thr Arg Ser Ile 
                325                 330                 335     


Glu Thr Gly Lys Thr Asn Tyr Asn Thr Cys Tyr Thr Ala Gly Val Cys 
            340                 345                 350         


Leu Leu Lys Ala Arg Gln Lys Ile Ala Val Lys Met Val His Ala Asp 
        355                 360                 365             


Ile Ser Ile Asn Met Ser Lys His Thr Thr Phe Phe Gly Ala Ile Arg 
    370                 375                 380                 


Leu Gly Glu Ala Pro Ala Ser 
385                 390     


<210>  53
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala 
1               5                   10                  15      


Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro 
            20                  25                  30          


Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala 
        35                  40                  45              


Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro 
    50                  55                  60                  


Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp 
65                  70                  75                  80  


Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe 
                85                  90                  95      


Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val 
            100                 105                 110         


Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala 
        115                 120                 125             


Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg 
    130                 135                 140                 


Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly 
145                 150                 155                 160 


Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala 
                165                 170                 175     


Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr 
            180                 185                 190         


Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
        195                 200                 205 


<210>  54
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide Linker

<400>  54

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  55

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  56
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  56

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  57

Gly Ser Pro Gly Ser Ser Ser Ser Gly Ser 
1               5                   10  


<210>  58
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  58

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  59
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  59

Gly Ser Gly Ser Gly Asn Gly Ser 
1               5               


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  60

Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               


<210>  61
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  61

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  62
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  62

Gly Gly Ser Gly 
1               


<210>  63
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  63

Gly Gly Ser Gly Asn Gly Ser Gly 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  64

Gly Gly Asn Gly Ser Gly Ser Gly 
1               5               


<210>  65
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Peptide linker

<400>  65

Gly Gly Asn Gly Ser Gly 
1               5       


<210>  66
<211>  2427
<212>  DNA
<213>  Artificial sequence

<220>
<223>  trimeric hu 4-1BBL (71-254) Fc knob chain

<400>  66
agagagggcc ctgagctgag ccccgatgat cctgctggac tgctggacct gcggcagggc       60

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg atggccccct gtcctggtac      120

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc      180

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg      240

agagtggtgg ccggcgaagg atctggctct gtgtctctgg ccctgcatct gcagcctctg      300

agaagcgctg ctggcgctgc agctctggca ctgacagtgg atctgcctcc tgccagctcc      360

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag      420

aggctgggag tgcatctgca cacagaggcc agggctagac acgcctggca gctgacacag      480

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg cctgccttct      540

ccaagaagcg aaggcggagg cggatctggc ggcggaggat ctagagaggg acccgaactg      600

tcccctgacg atccagccgg gctgctggat ctgagacagg gaatgttcgc ccagctggtg      660

gctcagaatg tgctgctgat tgacggacct ctgagctggt actccgaccc agggctggca      720

ggggtgtccc tgactggggg actgtcctac aaagaagata caaaagaact ggtggtggct      780

aaagctgggg tgtactatgt gttttttcag ctggaactga ggcgggtggt ggctggggag      840

ggctcaggat ctgtgtccct ggctctgcat ctgcagccac tgcgctctgc tgctggcgca      900

gctgcactgg ctctgactgt ggacctgcca ccagcctcta gcgaggccag aaacagcgcc      960

ttcgggttcc aaggacgcct gctgcatctg agcgccggac agcgcctggg agtgcatctg     1020

catactgaag ccagagcccg gcatgcttgg cagctgactc agggggcaac tgtgctggga     1080

ctgtttcgcg tgacacctga gatccctgcc ggactgccaa gccctagatc agaagggggc     1140

ggaggaagcg gagggggagg aagtagagaa ggaccagagc tgtctccaga tgaccccgca     1200

ggactgctgg acctgagaca gggcatgttc gcacagctgg tggcccagaa tgtgctgctg     1260

atcgacgggc cactgtcttg gtattccgat cccggcctgg ccggcgtgtc cctgaccggc     1320

ggactgagtt acaaagagga tacaaaagaa ctggtggtgg caaaggcagg ggtgtactat     1380

gtgttctttc agctggaact gagaagggtg gtggccggcg agggaagcgg atcagtgtca     1440

ctggcactgc atctgcagcc cctgagatcc gctgcagggg ccgctgctct ggccctgacc     1500

gtggacctgc cccctgcttc ttccgaggct agaaactctg catttgggtt tcaaggacgc     1560

ctgctgcatc tgtcagccgg gcagagactg ggagtgcatc tgcataccga ggctcgcgcc     1620

agacatgcat ggcagctgac ccagggcgcc accgtgctgg gactgtttag agtgactcca     1680

gaaatccccg ctggcctgcc cagcccaaga tccgagggat ctcctggcag cagctctagc     1740

ggatccgaca aaactcacac atgcccaccg tgcccagcac ctgaagctgc agggggaccg     1800

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag     1860

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac     1920

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc     1980

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     2040

tacaagtgca aggtctccaa caaagccctc ggcgccccca tcgagaaaac catctccaaa     2100

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgccg ggatgagctg     2160

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc     2220

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     2280

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     2340

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     2400

aagagcctct ccctgtctcc gggtaaa                                         2427


<210>  67
<211>  1338
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-FAP(28H1) Fc hole chain

<400>  67
gaagtgcagc tgctggaatc cggcggaggc ctggtgcagc ctggcggatc tctgagactg       60

tcctgcgccg cctccggctt caccttctcc tcccacgcca tgtcctgggt ccgacaggct      120

cctggcaaag gcctggaatg ggtgtccgcc atctgggcct ccggcgagca gtactacgcc      180

gactctgtga agggccggtt caccatctcc cgggacaact ccaagaacac cctgtacctg      240

cagatgaact ccctgcgggc cgaggacacc gccgtgtact actgtgccaa gggctggctg      300

ggcaacttcg actactgggg acagggcacc ctggtcaccg tgtccagcgc tagcaccaag      360

ggcccctccg tgttccccct ggcccccagc agcaagagca ccagcggcgg cacagccgct      420

ctgggctgcc tggtcaagga ctacttcccc gagcccgtga ccgtgtcctg gaacagcgga      480

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agagttctgg cctgtatagc      540

ctgagcagcg tggtcaccgt gccttctagc agcctgggca cccagaccta catctgcaac      600

gtgaaccaca agcccagcaa caccaaggtg gacaagaagg tggagcccaa gagctgcgac      660

aaaactcaca catgcccacc gtgcccagca cctgaagctg cagggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cggcgccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtgcaccctg cccccatccc gggatgagct gaccaagaac     1080

caggtcagcc tctcgtgcgc agtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc cgggtaaa                                                   1338


<210>  68
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-FAP(28H1) light chain

<400>  68
gagatcgtgc tgacccagtc ccccggcacc ctgtctctga gccctggcga gagagccacc       60

ctgtcctgca gagcctccca gtccgtgtcc cggtcctacc tcgcctggta tcagcagaag      120

cccggccagg cccctcggct gctgatcatc ggcgcctcta ccagagccac cggcatccct      180

gaccggttct ccggctctgg ctccggcacc gacttcaccc tgaccatctc ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggccagg tcatccctcc cacctttggc      300

cagggcacca aggtggaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  69
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-DP47 Fc hole chain

<400>  69
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgtg caccctgccc ccatcccggg atgagctgac caagaaccag     1080

gtcagcctct cgtgcgcagt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1140

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1200

tccttcttcc tcgtgagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1260

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1320

ctgtctccgg gtaaa                                                      1335


<210>  70
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  anti-DP47 light chain

<400>  70
gaaatcgtgt taacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc       60

ctctcttgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa      120

cctggccagg ctcccaggct cctcatctat ggagcatcca gcagggccac tggcatccca      180

gacaggttca gtggcagtgg atccgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct gacgttcggc      300

caggggacca aagtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  71
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-DP47 Fc hole chain

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  72
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  anti-DP47 light chain

<400>  72

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  73
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  73

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  74
<211>  163
<212>  PRT
<213>  cynomolgus

<400>  74

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln 
            


<210>  75
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  75

Val Gln Asn Ser Cys Asp Asn Cys Gln Pro Gly Thr Phe Cys Arg Lys 
1               5                   10                  15      


Tyr Asn Pro Val Cys Lys Ser Cys Pro Pro Ser Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Gly Gln Pro Asn Cys Asn Ile Cys Arg Val Cys Ala Gly Tyr Phe 
        35                  40                  45              


Arg Phe Lys Lys Phe Cys Ser Ser Thr His Asn Ala Glu Cys Glu Cys 
    50                  55                  60                  


Ile Glu Gly Phe His Cys Leu Gly Pro Gln Cys Thr Arg Cys Glu Lys 
65                  70                  75                  80  


Asp Cys Arg Pro Gly Gln Glu Leu Thr Lys Gln Gly Cys Lys Thr Cys 
                85                  90                  95      


Ser Leu Gly Thr Phe Asn Asp Gln Asn Gly Thr Gly Val Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Arg Ser Val Leu Lys Thr Gly Thr 
        115                 120                 125             


Thr Glu Lys Asp Val Val Cys Gly Pro Pro Val Val Ser Phe Ser Pro 
    130                 135                 140                 


Ser Thr Thr Ile Ser Val Thr Pro Glu Gly Gly Pro Gly Gly His Ser 
145                 150                 155                 160 


Leu Gln Val Leu 
                


<210>  76
<211>  681
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fc hole chain

<400>  76
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  77
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  human 4-1BB Fc knob chain

<400>  77
ctgcaggacc cctgcagcaa ctgccctgcc ggcaccttct gcgacaacaa ccggaaccag       60

atctgcagcc cctgcccccc caacagcttc agctctgccg gcggacagcg gacctgcgac      120

atctgcagac agtgcaaggg cgtgttcaga acccggaaag agtgcagcag caccagcaac      180

gccgagtgcg actgcacccc cggcttccat tgtctgggag ccggctgcag catgtgcgag      240

caggactgca agcagggcca ggaactgacc aagaagggct gcaaggactg ctgcttcggc      300

accttcaacg accagaagcg gggcatctgc cggccctgga ccaactgtag cctggacggc      360

aagagcgtgc tggtcaacgg caccaaagaa cgggacgtcg tgtgcggccc cagccctgct      420

gatctgtctc ctggggccag cagcgtgacc cctcctgccc ctgccagaga gcctggccac      480

tctcctcagg tcgacgaaca gttatatttt cagggcggct cacccaaatc tgcagacaaa      540

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      600

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      660

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      720

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      780

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      840

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      900

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag      960

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1020

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1080

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1140

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1200

ctgtctccgg gtaaatccgg aggcctgaac gacatcttcg aggcccagaa gattgaatgg     1260

cacgag                                                                1266


<210>  78
<211>  1266
<212>  DNA
<213>  Artificial sequence

<220>
<223>  cynomolgus 4-1BB Fc knob chain

<400>  78
ttgcaggatc tgtgtagtaa ctgcccagct ggtacattct gtgataataa caggagtcag       60

atttgcagtc cctgtcctcc aaatagtttc tccagcgcag gtggacaaag gacctgtgac      120

atatgcaggc agtgtaaagg tgttttcaag accaggaagg agtgttcctc caccagcaat      180

gcagagtgtg actgcatttc agggtatcac tgcctggggg cagagtgcag catgtgtgaa      240

caggattgta aacaaggtca agaattgaca aaaaaaggtt gtaaagactg ttgctttggg      300

acatttaatg accagaaacg tggcatctgt cgcccctgga caaactgttc tttggatgga      360

aagtctgtgc ttgtgaatgg gacgaaggag agggacgtgg tctgcggacc atctccagcc      420

gacctctctc caggagcatc ctctgcgacc ccgcctgccc ctgcgagaga gccaggacac      480

tctccgcagg tcgacgaaca gttatatttt cagggcggct cacccaaatc tgcagacaaa      540

actcacacat gcccaccgtg cccagcacct gaactcctgg ggggaccgtc agtcttcctc      600

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      660

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      720

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      780

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      840

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag      900

ccccgagaac cacaggtgta caccctgccc ccatgccggg atgagctgac caagaaccag      960

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1020

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1080

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     1140

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc     1200

ctgtctccgg gtaaatccgg aggcctgaac gacatcttcg aggcccagaa gattgaatgg     1260

cacgag                                                                1266


<210>  79
<211>  1269
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Murine 4-1BB Fc knob chain

<400>  79
gtgcagaaca gctgcgacaa ctgccagccc ggcaccttct gccggaagta caaccccgtg       60

tgcaagagct gcccccccag caccttcagc agcatcggcg gccagcccaa ctgcaacatc      120

tgcagagtgt gcgccggcta cttccggttc aagaagttct gcagcagcac ccacaacgcc      180

gagtgcgagt gcatcgaggg cttccactgc ctgggccccc agtgcaccag atgcgagaag      240

gactgcagac ccggccagga actgaccaag cagggctgta agacctgcag cctgggcacc      300

ttcaacgacc agaacgggac cggcgtgtgc cggccttgga ccaattgcag cctggacggg      360

agaagcgtgc tgaaaaccgg caccaccgag aaggacgtcg tgtgcggccc tcccgtggtg      420

tccttcagcc ctagcaccac catcagcgtg acccctgaag gcggccctgg cggacactct      480

ctgcaggtcc tggtcgacga acagttatat tttcagggcg gctcacccaa atctgcagac      540

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      600

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      660

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      720

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      780

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      840

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      900

cagccccgag aaccacaggt gtacaccctg cccccatgcc gggatgagct gaccaagaac      960

caggtcagcc tgtggtgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1020

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1080

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1140

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1200

tccctgtctc cgggtaaatc cggaggcctg aacgacatct tcgaggccca gaagattgaa     1260

tggcacgag                                                             1269


<210>  80
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fc hole chain

<400>  80

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  81
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 4-1BB Fc knob chain

<400>  81

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys 
                165                 170                 175     


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  82
<211>  422
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cynomolgus 4-1BB Fc knob chain

<400>  82

Leu Gln Asp Leu Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Ser Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Lys Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Ile Ser Gly Tyr His Cys Leu Gly Ala Glu Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Ala Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys 
                165                 170                 175     


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            180                 185                 190         


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        195                 200                 205             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    210                 215                 220                 


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
225                 230                 235                 240 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                245                 250                 255     


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            260                 265                 270         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        275                 280                 285             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    290                 295                 300                 


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
305                 310                 315                 320 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                325                 330                 335     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            340                 345                 350         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        355                 360                 365             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    370                 375                 380                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
385                 390                 395                 400 


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
                405                 410                 415     


Lys Ile Glu Trp His Glu 
            420         


<210>  83
<211>  423
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine 4-1BB Fc knob chain

<400>  83

Val Gln Asn Ser Cys Asp Asn Cys Gln Pro Gly Thr Phe Cys Arg Lys 
1               5                   10                  15      


Tyr Asn Pro Val Cys Lys Ser Cys Pro Pro Ser Thr Phe Ser Ser Ile 
            20                  25                  30          


Gly Gly Gln Pro Asn Cys Asn Ile Cys Arg Val Cys Ala Gly Tyr Phe 
        35                  40                  45              


Arg Phe Lys Lys Phe Cys Ser Ser Thr His Asn Ala Glu Cys Glu Cys 
    50                  55                  60                  


Ile Glu Gly Phe His Cys Leu Gly Pro Gln Cys Thr Arg Cys Glu Lys 
65                  70                  75                  80  


Asp Cys Arg Pro Gly Gln Glu Leu Thr Lys Gln Gly Cys Lys Thr Cys 
                85                  90                  95      


Ser Leu Gly Thr Phe Asn Asp Gln Asn Gly Thr Gly Val Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Arg Ser Val Leu Lys Thr Gly Thr 
        115                 120                 125             


Thr Glu Lys Asp Val Val Cys Gly Pro Pro Val Val Ser Phe Ser Pro 
    130                 135                 140                 


Ser Thr Thr Ile Ser Val Thr Pro Glu Gly Gly Pro Gly Gly His Ser 
145                 150                 155                 160 


Leu Gln Val Leu Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro 
                165                 170                 175     


Lys Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            180                 185                 190         


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        195                 200                 205             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    210                 215                 220                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
225                 230                 235                 240 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                245                 250                 255     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            260                 265                 270         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        275                 280                 285             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    290                 295                 300                 


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
305                 310                 315                 320 


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                325                 330                 335     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            340                 345                 350         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        355                 360                 365             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    370                 375                 380                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
385                 390                 395                 400 


Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
                405                 410                 415     


Gln Lys Ile Glu Trp His Glu 
            420             


<210>  84
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Avi tag

<400>  84

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  85
<211>  594
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human 4-1BB his tagged

<400>  85
ctgcaggacc cctgcagcaa ctgccctgcc ggcaccttct gcgacaacaa ccggaaccag       60

atctgcagcc cctgcccccc caacagcttc agctctgccg gcggacagcg gacctgcgac      120

atctgcagac agtgcaaggg cgtgttcaga acccggaaag agtgcagcag caccagcaac      180

gccgagtgcg actgcacccc cggcttccat tgtctgggag ccggctgcag catgtgcgag      240

caggactgca agcagggcca ggaactgacc aagaagggct gcaaggactg ctgcttcggc      300

accttcaacg accagaagcg gggcatctgc cggccctgga ccaactgtag cctggacggc      360

aagagcgtgc tggtcaacgg caccaaagaa cgggacgtcg tgtgcggccc cagccctgct      420

gatctgtctc ctggggccag cagcgtgacc cctcctgccc ctgccagaga gcctggccac      480

tctcctcagg tcgacgaaca gttatatttt cagggcggct caggcctgaa cgacatcttc      540

gaggcccaga agatcgagtg gcacgaggct cgagctcacc accatcacca tcac            594


<210>  86
<211>  198
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human 4-1BB His tagged

<400>  86

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Gly Leu 
                165                 170                 175     


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Ala Arg Ala 
            180                 185                 190         


His His His His His His 
        195             


<210>  87
<211>  1968
<212>  DNA
<213>  Artificial sequence

<220>
<223>  trimeric hu OX40L(51-183) Fc knob chain

<400>  87
caggtgtccc acagataccc cagaatccag agcatcaagg tgcagttcac cgagtacaag       60

aaagagaagg gcttcatcct gaccagccag aaagaggacg agatcatgaa ggtgcaggac      120

aacagcgtga tcatcaactg cgacggcttc tacctgatca gcctgaaggg ctacttcagc      180

caggaagtgg acatcagcct gcactaccag aaggacgagg aacccctgtt ccagctgaag      240

aaagtgcgga gcgtgaacag cctgatggtg gccagcctga cctacaagga caaggtgtac      300

ctgaacgtga ccaccgacaa caccagcctg gacgacttcc acgtgaacgg cggcgagctg      360

atcctgattc accagaaccc cggcgagttc tgcgtgctgg gaggcggagg atctggcgga      420

ggcggatctc aggtgtcaca ccgctacccc cggattcagt ccattaaggt gcagtttaca      480

gagtataaga aagaaaaagg ctttattctg acttcccaga aagaagatga gattatgaag      540

gtgcaggata attctgtgat catcaattgt gatgggtttt atctgatctc cctgaaagga      600

tactttagtc aggaagtgga tatttctctg cactatcaga aagatgaaga acctctgttc      660

cagctgaaaa aagtgcgctc cgtgaattct ctgatggtgg cttccctgac atacaaagac      720

aaagtgtatc tgaatgtgac aacagataat acctccctgg atgatttcca tgtgaatggg      780

ggggaactga ttctgatcca tcagaaccct ggggaatttt gtgtgctggg cggaggggga      840

agtggcggcg gaggcagtca ggtgtcccat cggtatccta gaatccagtc tatcaaagtg      900

cagtttactg agtacaaaaa agagaaagga ttcattctga cctctcagaa agaggacgaa      960

attatgaagg tgcaggataa cagtgtgatt attaactgtg atgggttcta cctgatttct     1020

ctgaagggat atttcagtca ggaagtggac atctcactgc attaccagaa ggatgaagaa     1080

ccactgttcc agctgaagaa agtgcgctct gtgaatagcc tgatggtggc ctctctgact     1140

tataaggata aggtgtacct gaatgtgaca actgacaata cttctctgga cgactttcat     1200

gtgaacgggg gagagctgat tctgatccac cagaatccag gcgagttttg tgtgctggga     1260

agccccggca gcagcagctc tggatccgac aaaactcaca catgcccacc gtgcccagca     1320

cctgaagctg cagggggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc     1380

atgatctccc ggacccctga ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct     1440

gaggtcaagt tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagccg     1500

cgggaggagc agtacaacag cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag     1560

gactggctga atggcaagga gtacaagtgc aaggtctcca acaaagccct cggcgccccc     1620

atcgagaaaa ccatctccaa agccaaaggg cagccccgag aaccacaggt gtacaccctg     1680

cccccatgcc gggatgagct gaccaagaac caggtcagcc tgtggtgcct ggtcaaaggc     1740

ttctatccca gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac     1800

aagaccacgc ctcccgtgct ggactccgac ggctccttct tcctctacag caagctcacc     1860

gtggacaaga gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct     1920

ctgcacaacc actacacgca gaagagcctc tccctgtctc cgggtaaa                  1968


<210>  88
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  88

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala 
            180                 185     


<210>  89
<211>  186
<212>  PRT
<213>  cynomolgus

<400>  89

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala 
            180                 185     


<210>  90
<211>  192
<212>  PRT
<213>  Mus musculus

<400>  90

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


<210>  91
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human OX40 Fc knob chain

<400>  91
ctgcactgcg tgggcgacac ctaccccagc aacgaccggt gctgccacga gtgcagaccc       60

ggcaacggca tggtgtcccg gtgcagccgg tcccagaaca ccgtgtgcag accttgcggc      120

cctggcttct acaacgacgt ggtgtccagc aagccctgca agccttgtac ctggtgcaac      180

ctgcggagcg gcagcgagcg gaagcagctg tgtaccgcca cccaggatac cgtgtgccgg      240

tgtagagccg gcacccagcc cctggacagc tacaaacccg gcgtggactg cgccccttgc      300

cctcctggcc acttcagccc tggcgacaac caggcctgca agccttggac caactgcacc      360

ctggccggca agcacaccct gcagcccgcc agcaatagca gcgacgccat ctgcgaggac      420

cgggatcctc ctgccaccca gcctcaggaa acccagggcc ctcccgccag acccatcacc      480

gtgcagccta cagaggcctg gcccagaacc agccaggggc ctagcaccag acccgtggaa      540

gtgcctggcg gcagagccgt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  92
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Cynomolgus OX40 Fc knob chain

<400>  92
ctccactgtg tcggggacac ctaccccagc aacgaccggt gctgtcagga gtgcaggcca       60

ggcaacggga tggtgagccg ctgcaaccgc tcccagaaca cggtgtgccg tccgtgcggg      120

cccggcttct acaacgacgt ggtcagcgcc aagccctgca aggcctgcac atggtgcaac      180

ctcagaagtg ggagtgagcg gaaacagccg tgcacggcca cacaggacac agtctgccgc      240

tgccgggcgg gcacccagcc cctggacagc tacaagcctg gagttgactg tgccccctgc      300

cctccagggc acttctcccc gggcgacaac caggcctgca agccctggac caactgcacc      360

ttggccggga agcacaccct gcagccagcc agcaatagct cggacgccat ctgtgaggac      420

agggaccccc cacccacaca gccccaggag acccagggcc ccccggccag gcccaccact      480

gtccagccca ctgaagcctg gcccagaacc tcacagagac cctccacccg gcccgtggag      540

gtccccaggg gccctgcggt cgacgaacag ttatattttc agggcggctc acccaaatct      600

gcagacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg gggaccgtca      660

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      720

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      780

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      840

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      900

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      960

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgccggga tgagctgacc     1020

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg     1080

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1140

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag     1200

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag     1260

agcctctccc tgtctccggg taaatccgga ggcctgaacg acatcttcga ggcccagaag     1320

attgaatggc acgag                                                      1335


<210>  93
<211>  1353
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Murine OX40 Fc knob chain

<400>  93
gtgaccgcca gacggctgaa ctgcgtgaag cacacctacc ccagcggcca caagtgctgc       60

agagagtgcc agcccggcca cggcatggtg tccagatgcg accacacacg ggacaccctg      120

tgccaccctt gcgagacagg cttctacaac gaggccgtga actacgatac ctgcaagcag      180

tgcacccagt gcaaccacag aagcggcagc gagctgaagc agaactgcac ccccacccag      240

gataccgtgt gcagatgcag acccggcacc cagcccagac aggacagcgg ctacaagctg      300

ggcgtggact gcgtgccctg ccctcctggc cacttcagcc ccggcaacaa ccaggcctgc      360

aagccctgga ccaactgcac cctgagcggc aagcagacca gacaccccgc cagcgacagc      420

ctggatgccg tgtgcgagga cagaagcctg ctggccaccc tgctgtggga gacacagcgg      480

cccaccttca gacccaccac cgtgcagagc accaccgtgt ggcccagaac cagcgagctg      540

cccagtcctc ctaccctcgt gacacctgag ggccccgtcg acgaacagtt atattttcag      600

ggcggctcac ccaaatctgc agacaaaact cacacatgcc caccgtgccc agcacctgaa      660

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      720

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      780

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      840

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      900

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag      960

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1020

tgccgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1080

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1140

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1200

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1260

aaccactaca cgcagaagag cctctccctg tctccgggta aatccggagg cctgaacgac     1320

atcttcgagg cccagaagat tgaatggcac gag                                  1353


<210>  94
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human OX40 Fc knob chain

<400>  94

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  95
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Cynomolgus OX40 Fc knob chain

<400>  95

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys Gln 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Asn Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ala Lys Pro Cys Lys Ala Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Pro Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Pro Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Thr Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Arg Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Arg Gly Pro Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp Lys Thr His Thr Cys Pro 
        195                 200                 205             


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    210                 215                 220                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
225                 230                 235                 240 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                245                 250                 255     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            260                 265                 270         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        275                 280                 285             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    290                 295                 300                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
305                 310                 315                 320 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg 
                325                 330                 335     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly 
            340                 345                 350         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        355                 360                 365             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    370                 375                 380                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
385                 390                 395                 400 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                405                 410                 415     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu 
            420                 425                 430         


Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
        435                 440                 445 


<210>  96
<211>  451
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Murine OX40 Fc knob chain

<400>  96

Val Thr Ala Arg Arg Leu Asn Cys Val Lys His Thr Tyr Pro Ser Gly 
1               5                   10                  15      


His Lys Cys Cys Arg Glu Cys Gln Pro Gly His Gly Met Val Ser Arg 
            20                  25                  30          


Cys Asp His Thr Arg Asp Thr Leu Cys His Pro Cys Glu Thr Gly Phe 
        35                  40                  45              


Tyr Asn Glu Ala Val Asn Tyr Asp Thr Cys Lys Gln Cys Thr Gln Cys 
    50                  55                  60                  


Asn His Arg Ser Gly Ser Glu Leu Lys Gln Asn Cys Thr Pro Thr Gln 
65                  70                  75                  80  


Asp Thr Val Cys Arg Cys Arg Pro Gly Thr Gln Pro Arg Gln Asp Ser 
                85                  90                  95      


Gly Tyr Lys Leu Gly Val Asp Cys Val Pro Cys Pro Pro Gly His Phe 
            100                 105                 110         


Ser Pro Gly Asn Asn Gln Ala Cys Lys Pro Trp Thr Asn Cys Thr Leu 
        115                 120                 125             


Ser Gly Lys Gln Thr Arg His Pro Ala Ser Asp Ser Leu Asp Ala Val 
    130                 135                 140                 


Cys Glu Asp Arg Ser Leu Leu Ala Thr Leu Leu Trp Glu Thr Gln Arg 
145                 150                 155                 160 


Pro Thr Phe Arg Pro Thr Thr Val Gln Ser Thr Thr Val Trp Pro Arg 
                165                 170                 175     


Thr Ser Glu Leu Pro Ser Pro Pro Thr Leu Val Thr Pro Glu Gly Pro 
            180                 185                 190         


Val Asp Glu Gln Leu Tyr Phe Gln Gly Gly Ser Pro Lys Ser Ala Asp 
        195                 200                 205             


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
    210                 215                 220                 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
225                 230                 235                 240 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
                245                 250                 255     


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
            260                 265                 270         


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
        275                 280                 285             


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
    290                 295                 300                 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
305                 310                 315                 320 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
                325                 330                 335     


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
            340                 345                 350         


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
        355                 360                 365             


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
    370                 375                 380                 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
385                 390                 395                 400 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
                405                 410                 415     


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
            420                 425                 430         


Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
        435                 440                 445             


Trp His Glu 
    450     


<210>  97
<211>  663
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Human OX40 His tagged

<400>  97
ctgcactgcg tgggcgacac ctaccccagc aacgaccggt gctgccacga gtgcagaccc       60

ggcaacggca tggtgtcccg gtgcagccgg tcccagaaca ccgtgtgcag accttgcggc      120

cctggcttct acaacgacgt ggtgtccagc aagccctgca agccttgtac ctggtgcaac      180

ctgcggagcg gcagcgagcg gaagcagctg tgtaccgcca cccaggatac cgtgtgccgg      240

tgtagagccg gcacccagcc cctggacagc tacaaacccg gcgtggactg cgccccttgc      300

cctcctggcc acttcagccc tggcgacaac caggcctgca agccttggac caactgcacc      360

ctggccggca agcacaccct gcagcccgcc agcaatagca gcgacgccat ctgcgaggac      420

cgggatcctc ctgccaccca gcctcaggaa acccagggcc ctcccgccag acccatcacc      480

gtgcagccta cagaggcctg gcccagaacc agccaggggc ctagcaccag acccgtggaa      540

gtgcctggcg gcagagccgt cgacgaacag ttatattttc agggcggctc aggcctgaac      600

gacatcttcg aggcccagaa gatcgagtgg cacgaggctc gagctcacca ccatcaccat      660

cac                                                                    663


<210>  98
<211>  221
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Human OX40 His tagged

<400>  98

Leu His Cys Val Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His 
1               5                   10                  15      


Glu Cys Arg Pro Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln 
            20                  25                  30          


Asn Thr Val Cys Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val 
        35                  40                  45              


Ser Ser Lys Pro Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly 
    50                  55                  60                  


Ser Glu Arg Lys Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg 
65                  70                  75                  80  


Cys Arg Ala Gly Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp 
                85                  90                  95      


Cys Ala Pro Cys Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala 
            100                 105                 110         


Cys Lys Pro Trp Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln 
        115                 120                 125             


Pro Ala Ser Asn Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro 
    130                 135                 140                 


Ala Thr Gln Pro Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr 
145                 150                 155                 160 


Val Gln Pro Thr Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr 
                165                 170                 175     


Arg Pro Val Glu Val Pro Gly Gly Arg Ala Val Asp Glu Gln Leu Tyr 
            180                 185                 190         


Phe Gln Gly Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
        195                 200                 205             


Glu Trp His Glu Ala Arg Ala His His His His His His 
    210                 215                 220     


<210>  99
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  99

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu 
        


<210>  100
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  100

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val 
1               5                   10                  15      


Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala 
            20                  25                  30          


Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu 
        35                  40                  45              


Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu 
    50                  55                  60                  


Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala 
65                  70                  75                  80  


Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala 
                85                  90                  95      


Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala 
            100                 105                 110         


Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu 
        115                 120                 125             


Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu 
    130                 135                 140                 


Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile 
145                 150                 155                 160 


Pro Ala Gly Leu 
                


<210>  101
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  101

Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu 
1               5                   10                  15      


Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser 
            20                  25                  30          


Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys 
        35                  40                  45              


Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val 
    50                  55                  60                  


Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly 
65                  70                  75                  80  


Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly 
                85                  90                  95      


Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu 
            100                 105                 110         


Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser 
        115                 120                 125             


Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg 
    130                 135                 140                 


His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg 
145                 150                 155                 160 


Val Thr Pro Glu Ile Pro Ala Gly Leu 
                165                 


<210>  102
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  102

Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser Ala Ala Ser 
1               5                   10                  15      


Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly 
            20                  25                  30          


Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn 
        35                  40                  45              


Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu 
    50                  55                  60                  


Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys 
65                  70                  75                  80  


Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu 
                85                  90                  95      


Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu 
            100                 105                 110         


Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu 
        115                 120                 125             


Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser 
    130                 135                 140                 


Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg 
145                 150                 155                 160 


Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln 
                165                 170                 175     


Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu 
            180                 185                 190         


Ile Pro Ala Gly Leu 
        195         


<210>  103
<211>  555
<212>  PRT
<213>  Artificial sequence

<220>
<223>  trimeric hu 4-1BBL (71-248) connected by (G4S)2 linker

<400>  103

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
1               5                   10                  15      


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
            20                  25                  30          


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
        35                  40                  45              


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
    50                  55                  60                  


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
65                  70                  75                  80  


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
                85                  90                  95      


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
            100                 105                 110         


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
        115                 120                 125             


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
    130                 135                 140                 


His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln 
145                 150                 155                 160 


Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala 
                165                 170                 175     


Gly Leu Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly 
            180                 185                 190         


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
        195                 200                 205             


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
    210                 215                 220                 


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
225                 230                 235                 240 


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
                245                 250                 255     


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
            260                 265                 270         


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
        275                 280                 285             


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
    290                 295                 300                 


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
305                 310                 315                 320 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
                325                 330                 335     


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
            340                 345                 350         


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser 
    370                 375                 380                 


Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala 
385                 390                 395                 400 


Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp 
                405                 410                 415     


Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser 
            420                 425                 430         


Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr 
        435                 440                 445             


Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly 
    450                 455                 460                 


Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala 
465                 470                 475                 480 


Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser 
                485                 490                 495     


Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His 
            500                 505                 510         


Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg 
        515                 520                 525             


Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu 
    530                 535                 540                 


Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
545                 550                 555 


<210>  104
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-H1

<400>  104

Ser Tyr Ala Met Ser 
1               5   


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-H2

<400>  105

Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-H3

<400>  106

Gly Trp Phe Gly Gly Phe Asn Tyr 
1               5               


<210>  107
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-L1

<400>  107

Arg Ala Ser Gln Ser Val Thr Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-L2

<400>  108

Val Gly Ser Arg Arg Ala Thr 
1               5           


<210>  109
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  CDR-L3

<400>  109

Gln Gln Gly Ile Met Leu Pro Pro Thr 
1               5                   


<210>  110
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  VH

<400>  110

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  111
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAP(4B9)  VL

<400>  111

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  112
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) CDR-H1

<400>  112

Asp Ser Tyr Met His 
1               5   


<210>  113
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) CDR-H2

<400>  113

Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) CDR-H3

<400>  114

Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) CDR-L1

<400>  115

Ser Ala Ser Ser Ser Val Pro Tyr Met His 
1               5                   10  


<210>  116
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) CDR-L2

<400>  116

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) CDR-L3

<400>  117

Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
1               5                   


<210>  118
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) VH

<400>  118

Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  119
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CEA(sm9b) VL

<400>  119

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Ser Ala Ser Ser Ser Val Pro Tyr Met 
            20                  25                  30          


His Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Val Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) CDR-H1

<400>  120

Asp Tyr Ile Met His 
1               5   


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) CDR-H2

<400>  121

Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) CDR-H3

<400>  122

Gly Thr Tyr Tyr Tyr Gly Ser Ala Leu Phe Asp Tyr 
1               5                   10          


<210>  123
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) CDR-L1

<400>  123

Lys Ser Ser Gln Ser Leu Glu Asn Pro Asn Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) CDR-L2

<400>  124

Arg Val Ser Lys Arg Phe Ser 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) CDR-L3

<400>  125

Leu Gln Leu Thr His Val Pro Tyr Thr 
1               5                   


<210>  126
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) VH

<400>  126

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Ala Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  127
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-018) VL

<400>  127

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Glu Asn Pro 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Leu 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  128
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) CDR-H1

<400>  128

Asp Tyr Ile Met His 
1               5   


<210>  129
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) CDR-H2

<400>  129

Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) CDR-H3

<400>  130

Gly Thr Tyr Tyr Tyr Gly Pro Gln Leu Phe Asp Tyr 
1               5                   10          


<210>  131
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) CDR-L1

<400>  131

Lys Ser Ser Gln Ser Leu Glu Thr Ser Thr Gly Thr Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  132
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) CDR-L2

<400>  132

Arg Val Ser Lys Arg Phe Ser 
1               5           


<210>  133
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) CDR-L3

<400>  133

Leu Gln Leu Leu Glu Asp Pro Tyr Thr 
1               5                   


<210>  134
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) VH

<400>  134

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Pro Gln Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  135
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD19 (8B8-2B11) VL

<400>  135

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Glu Thr Ser 
            20                  25                  30          


Thr Gly Thr Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Leu 
                85                  90                  95      


Leu Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  136
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide linker G4S

<400>  136

Gly Gly Gly Gly Ser 
1               5   


<210>  137
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti-FAP(4B9) Fc hole chain

<400>  137
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcggct ctggcgccag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggcccct ccgtgttccc cctggccccc agcagcaaga gcaccagcgg cggcacagcc      420

gctctgggct gcctggtcaa ggactacttc cccgagcccg tgaccgtgtc ctggaacagc      480

ggagccctga cctccggcgt gcacaccttc cccgccgtgc tgcagagttc tggcctgtat      540

agcctgagca gcgtggtcac cgtgccttct agcagcctgg gcacccagac ctacatctgc      600

aacgtgaacc acaagcccag caacaccaag gtggacaaga aggtggagcc caagagctgc      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag     1080

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  138
<211>  3084
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti-FAP(4B9) Fc knob chain fused to 
       trimeric hu 4-1BBL (71-254)

<400>  138
gaggtgcagc tgctcgaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctacgcca tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccgcc atcatcggct ctggcgccag cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagggatgg      300

ttcggcggct tcaactactg gggacagggc accctggtca cagtgtccag cgctagcacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660

gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccct gcagagatga gctgaccaag     1080

aaccaggtgt ccctgtggtg cctcgtgaag ggcttctacc cctccgatat cgccgtggaa     1140

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc     1200

gacggctcat tcttcctgta ctccaagctg accgtggaca agagccggtg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgagcctga gccctggcgg aggcggagga tctggcgggg gaggatctag agagggccct     1380

gagctgtccc ccgatgatcc tgctggactg ctggacctgc ggcagggcat gtttgctcag     1440

ctggtggccc agaacgtgct gctgatcgac ggccctctga gctggtacag cgatcctgga     1500

ctggctggcg tgtcactgac aggcggcctg agctacaaag aggacaccaa agaactggtg     1560

gtggccaagg ccggcgtgta ctacgtgttc tttcagctgg aactgcggag agtggtggcc     1620

ggcgagggat ctggatctgt gtctctggcc ctgcatctgc agcccctgag atcagctgct     1680

ggcgctgctg ctctggctct gacagtggat ctgcctcctg ccagcagcga ggcccggaat     1740

agcgcatttg ggtttcaagg caggctgctg cacctgtctg ccggccagag gctgggagtg     1800

catctgcaca cagaagccag agccaggcac gcttggcagc tgacacaggg cgctacagtg     1860

ctgggcctgt tcagagtgac ccccgagatt ccagccggcc tgccttctcc aagaagcgaa     1920

ggcggcggag gctccggagg aggcggctct agagaaggac ctgaactgag cccagacgac     1980

cccgcagggc tgctggatct gagacaggga atgttcgccc agctggtggc tcagaatgtg     2040

ctgctgattg atggacccct gtcctggtac tccgacccag ggctggcagg ggtgtccctg     2100

actggcggac tgtcttacaa agaagataca aaagaactgg tggtggctaa agctggggtg     2160

tactatgtgt tttttcagct ggaactgagg cgggtggtgg ctggggaagg cagtggctct     2220

gtgtccctgg cactgcatct gcagcctctg cgcagtgctg caggcgcagc cgcactggca     2280

ctgactgtgg acctgccccc agcttccagc gaggctagaa acagcgcctt cgggtttcaa     2340

ggacgcctgc tgcatctgag cgccggacag cgcctgggag tgcatctgca tactgaggct     2400

agggccagac atgcctggca gctgacccag ggggcaactg tgctgggact gtttcgcgtg     2460

acacctgaga tccccgctgg cctgccaagc cctagatcag aaggcggagg gggatcaggg     2520

ggaggcggat ccagagaggg ccctgagctg agccccgatg atcctgctgg actgctggac     2580

ctgcggcagg gcatgtttgc tcagctggtg gcccagaacg tgctgctgat cgatggcccc     2640

ctgtcctggt acagcgatcc tggactggct ggcgtgtcac tgacaggcgg cctgagctac     2700

aaagaggaca ccaaagaact ggtggtggcc aaggccggcg tgtactacgt gttctttcag     2760

ctggaactgc ggagagtggt ggccggcgaa ggatctggct ctgtgtctct ggccctgcat     2820

ctgcagcctc tgagaagcgc tgctggcgct gcagctctgg cactgacagt ggatctgcct     2880

cctgccagct ccgaggcccg gaatagcgca tttgggtttc aaggcaggct gctgcacctg     2940

tctgccggcc agaggctggg agtgcatctg cacacagagg ccagggctag acacgcctgg     3000

cagctgacac agggcgctac agtgctgggc ctgttcagag tgacccccga gattccagcc     3060

ggcctgcctt ctccaagaag cgaa                                            3084


<210>  139
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti-FAP(4B9) light chain

<400>  139
gagatcgtgc tgacccagtc ccccggcacc ctgtctctga gccctggcga gagagccacc       60

ctgtcctgca gagcctccca gtccgtgacc tcctcctacc tcgcctggta tcagcagaag      120

cccggccagg cccctcggct gctgatcaac gtgggcagtc ggagagccac cggcatccct      180

gaccggttct ccggctctgg ctccggcacc gacttcaccc tgaccatctc ccggctggaa      240

cccgaggact tcgccgtgta ctactgccag cagggcatca tgctgccccc cacctttggc      300

cagggcacca aggtggaaat caagcgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  140
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FAP(4B9) Fc hole chain

<400>  140

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  141
<211>  1028
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FAP(4B9) Fc knob chain fused to trimeric 4 hu 4-1BBL 
       (71-254)

<400>  141

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ile Gly Ser Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Trp Phe Gly Gly Phe Asn Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly 
        435                 440                 445             


Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro 
    450                 455                 460                 


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
465                 470                 475                 480 


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
                485                 490                 495     


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
            500                 505                 510         


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
        515                 520                 525             


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
    530                 535                 540                 


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
545                 550                 555                 560 


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
                565                 570                 575     


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
            580                 585                 590         


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
        595                 600                 605             


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
    610                 615                 620                 


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu 
                645                 650                 655     


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
            660                 665                 670         


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
        675                 680                 685             


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
    690                 695                 700                 


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
705                 710                 715                 720 


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
                725                 730                 735     


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
            740                 745                 750         


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
        755                 760                 765             


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
    770                 775                 780                 


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
785                 790                 795                 800 


Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly 
                805                 810                 815     


Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg 
            820                 825                 830         


Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
        835                 840                 845             


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
    850                 855                 860                 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
865                 870                 875                 880 


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
                885                 890                 895     


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
            900                 905                 910         


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
        915                 920                 925             


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
    930                 935                 940                 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
945                 950                 955                 960 


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
                965                 970                 975     


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
            980                 985                 990         


Glu Ala Arg Ala Arg His Ala Trp  Gln Leu Thr Gln Gly  Ala Thr Val 
        995                 1000                 1005             


Leu Gly  Leu Phe Arg Val Thr  Pro Glu Ile Pro Ala  Gly Leu Pro 
    1010                 1015                 1020             


Ser Pro  Arg Ser Glu 
    1025             


<210>  142
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-FAP(4B9) light chain

<400>  142

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Thr Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Asn Val Gly Ser Arg Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Gly Ile Met Leu Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  143
<211>  1350
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti-CEA(sm9b) Fc hole chain

<400>  143
caagtgaagc tggagcagag cggcgccgaa gtcgtgaaac ccggggcttc cgtcaagctc       60

tcttgcaagg catcaggatt caacatcaaa gacagctaca tgcactggct gaggcagggc      120

cctggtcagt gccttgagtg gattggctgg atcgatccag agaatggcga caccgaatat      180

gcccccaagt ttcaaggaaa ggctacattc accactgata catccgcaaa caccgcctac      240

ctgggtctct caagtctgcg ccctgaggac actgctgtgt attactgtaa tgagggcacc      300

ccaacagggc cctactattt tgactactgg ggacagggca ccttggttac agtgagctcc      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtgcaccc tgcccccatc ccgggatgag     1080

ctgaccaaga accaggtcag cctctcgtgc gcagtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcgtg agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  144
<211>  3093
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti-CEA(sm9b) Fc knob chain fused to 
       trimeric hu 4-1BBL (71-254)

<400>  144
caagtgaagc tggagcagag cggcgccgaa gtcgtgaaac ccggggcttc cgtcaagctc       60

tcttgcaagg catcaggatt caacatcaaa gacagctaca tgcactggct gaggcagggc      120

cctggtcagt gccttgagtg gattggctgg atcgatccag agaatggcga caccgaatat      180

gcccccaagt ttcaaggaaa ggctacattc accactgata catccgcaaa caccgcctac      240

ctgggtctct caagtctgcg ccctgaggac actgctgtgt attactgtaa tgagggcacc      300

ccaacagggc cctactattt tgactactgg ggacagggca ccttggttac agtgagctcc      360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg      420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagaa agttgagccc      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc tgcaggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcggcgccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccctg cagagatgag     1080

ctgaccaaga accaggtgtc cctgtggtgc ctcgtgaagg gcttctaccc ctccgatatc     1140

gccgtggaat gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg     1200

ctggacagcg acggctcatt cttcctgtac tccaagctga ccgtggacaa gagccggtgg     1260

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagtccc tgagcctgag ccctggcgga ggcggaggat ctggcggggg aggatctaga     1380

gagggccctg agctgtcccc cgatgatcct gctggactgc tggacctgcg gcagggcatg     1440

tttgctcagc tggtggccca gaacgtgctg ctgatcgacg gccctctgag ctggtacagc     1500

gatcctggac tggctggcgt gtcactgaca ggcggcctga gctacaaaga ggacaccaaa     1560

gaactggtgg tggccaaggc cggcgtgtac tacgtgttct ttcagctgga actgcggaga     1620

gtggtggccg gcgagggatc tggatctgtg tctctggccc tgcatctgca gcccctgaga     1680

tcagctgctg gcgctgctgc tctggctctg acagtggatc tgcctcctgc cagcagcgag     1740

gcccggaata gcgcatttgg gtttcaaggc aggctgctgc acctgtctgc cggccagagg     1800

ctgggagtgc atctgcacac agaagccaga gccaggcacg cttggcagct gacacagggc     1860

gctacagtgc tgggcctgtt cagagtgacc cccgagattc cagccggcct gccttctcca     1920

agaagcgaag gcggcggagg ctccggagga ggcggctcta gagaaggacc tgaactgagc     1980

ccagacgacc ccgcagggct gctggatctg agacagggaa tgttcgccca gctggtggct     2040

cagaatgtgc tgctgattga tggacccctg tcctggtact ccgacccagg gctggcaggg     2100

gtgtccctga ctggcggact gtcttacaaa gaagatacaa aagaactggt ggtggctaaa     2160

gctggggtgt actatgtgtt ttttcagctg gaactgaggc gggtggtggc tggggaaggc     2220

agtggctctg tgtccctggc actgcatctg cagcctctgc gcagtgctgc aggcgcagcc     2280

gcactggcac tgactgtgga cctgccccca gcttccagcg aggctagaaa cagcgccttc     2340

gggtttcaag gacgcctgct gcatctgagc gccggacagc gcctgggagt gcatctgcat     2400

actgaggcta gggccagaca tgcctggcag ctgacccagg gggcaactgt gctgggactg     2460

tttcgcgtga cacctgagat ccccgctggc ctgccaagcc ctagatcaga aggcggaggg     2520

ggatcagggg gaggcggatc cagagagggc cctgagctga gccccgatga tcctgctgga     2580

ctgctggacc tgcggcaggg catgtttgct cagctggtgg cccagaacgt gctgctgatc     2640

gatggccccc tgtcctggta cagcgatcct ggactggctg gcgtgtcact gacaggcggc     2700

ctgagctaca aagaggacac caaagaactg gtggtggcca aggccggcgt gtactacgtg     2760

ttctttcagc tggaactgcg gagagtggtg gccggcgaag gatctggctc tgtgtctctg     2820

gccctgcatc tgcagcctct gagaagcgct gctggcgctg cagctctggc actgacagtg     2880

gatctgcctc ctgccagctc cgaggcccgg aatagcgcat ttgggtttca aggcaggctg     2940

ctgcacctgt ctgccggcca gaggctggga gtgcatctgc acacagaggc cagggctaga     3000

cacgcctggc agctgacaca gggcgctaca gtgctgggcc tgttcagagt gacccccgag     3060

attccagccg gcctgccttc tccaagaagc gaa                                  3093


<210>  145
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti-CEA(sm9b) light chain

<400>  145
gagaacgtgc tgacccagag cccctcctct atgtcagtca gcgtgggcga cagggtcaca       60

atcgcctgct ccgcttctag tagcgtgcct tacatgcact ggctccagca gaagccaggg      120

aaatccccca agctgcttat ttattctacc tcaaatctgg caagcggagt tcctagcaga      180

ttctctggca gtggtagcgg gactgattac tccctcacaa tctcaagtgt gcagccagaa      240

gacgccgcta cctattactg tcaacagcgc agctcctacc ccctgacttt tggctgtggc      300

accaagttgg agattaaacg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgt                             639


<210>  146
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CEA(sm9b) Fc hole chain

<400>  146

Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  147
<211>  1031
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CEA(sm9b) Fc knob chain fused to trimeric hu 4-1BBL (71-254)

<400>  147

Gln Val Lys Leu Glu Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu 
    450                 455                 460                 


Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met 
465                 470                 475                 480 


Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu 
                485                 490                 495     


Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly 
            500                 505                 510         


Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly 
        515                 520                 525             


Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly 
    530                 535                 540                 


Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg 
545                 550                 555                 560 


Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro 
                565                 570                 575     


Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu 
            580                 585                 590         


Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu 
        595                 600                 605             


Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu 
    610                 615                 620                 


Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro 
625                 630                 635                 640 


Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly 
                645                 650                 655     


Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln 
            660                 665                 670         


Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly 
        675                 680                 685             


Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr 
    690                 695                 700                 


Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys 
705                 710                 715                 720 


Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val 
                725                 730                 735     


Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro 
            740                 745                 750         


Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu 
        755                 760                 765             


Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly 
    770                 775                 780                 


Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His 
785                 790                 795                 800 


Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr 
                805                 810                 815     


Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro 
            820                 825                 830         


Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
        835                 840                 845             


Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu 
    850                 855                 860                 


Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile 
865                 870                 875                 880 


Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser 
                885                 890                 895     


Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val 
            900                 905                 910         


Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg 
        915                 920                 925             


Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu 
    930                 935                 940                 


Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val 
945                 950                 955                 960 


Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe 
                965                 970                 975     


Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His 
            980                 985                 990         


Leu His Thr Glu Ala Arg Ala Arg  His Ala Trp Gln Leu  Thr Gln Gly 
        995                 1000                 1005             


Ala Thr  Val Leu Gly Leu Phe  Arg Val Thr Pro Glu  Ile Pro Ala 
    1010                 1015                 1020             


Gly Leu  Pro Ser Pro Arg Ser  Glu 
    1025                 1030     


<210>  148
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CEA(sm9b) light chain

<400>  148

Glu Asn Val Leu Thr Gln Ser Pro Ser Ser Met Ser Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys Ser Ala Ser Ser Ser Val Pro Tyr Met 
            20                  25                  30          


His Trp Leu Gln Gln Lys Pro Gly Lys Ser Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Ser Val Gln Pro Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  149
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti- CD19(8B8-018) Fc hole chain

<400>  149
caggtccagc tggtgcagtc cggcgccgag gtcaagaaac ccggggcttc tgtgaaggtt       60

tcatgcaagg caagcggata caccttcacc gactatatca tgcattgggt caggcaggcc      120

cctggccaag gtctcgaatg gatgggctac attaacccat ataatgatgg ctccaaatac      180

accgagaagt ttcagggaag agtcactatg acatctgaca ccagtatcag cactgcttac      240

atggagctgt cccgccttcg gtctgatgac accgcagtgt attactgtgc caggggcaca      300

tattactacg gctcagctct gttcgactat tgggggcagg gaaccacagt aaccgtgagc      360

tccgctagca ccaagggccc ctccgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgctctggg ctgcctggtc aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagt      540

tctggcctgt atagcctgag cagcgtggtc accgtgcctt ctagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtgca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctctcg tgcgcagtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  150
<211>  3096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti- CD19(8B8-018) Fc knob chain fused to
       trimeric hu 4-1BBL (71-254)

<400>  150
caggtccagc tggtgcagtc cggcgccgag gtcaagaaac ccggggcttc tgtgaaggtt       60

tcatgcaagg caagcggata caccttcacc gactatatca tgcattgggt caggcaggcc      120

cctggccaag gtctcgaatg gatgggctac attaacccat ataatgatgg ctccaaatac      180

accgagaagt ttcagggaag agtcactatg acatctgaca ccagtatcag cactgcttac      240

atggagctgt cccgccttcg gtctgatgac accgcagtgt attactgtgc caggggcaca      300

tattactacg gctcagctct gttcgactat tgggggcagg gaaccacagt aaccgtgagc      360

tccgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc ctgcagagat     1080

gagctgacca agaaccaggt gtccctgtgg tgcctcgtga agggcttcta cccctccgat     1140

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct     1200

gtgctggaca gcgacggctc attcttcctg tactccaagc tgaccgtgga caagagccgg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccctggc ggaggcggag gatctggcgg gggaggatct     1380

agagagggcc ctgagctgtc ccccgatgat cctgctggac tgctggacct gcggcagggc     1440

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg acggccctct gagctggtac     1500

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc     1560

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg     1620

agagtggtgg ccggcgaggg atctggatct gtgtctctgg ccctgcatct gcagcccctg     1680

agatcagctg ctggcgctgc tgctctggct ctgacagtgg atctgcctcc tgccagcagc     1740

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag     1800

aggctgggag tgcatctgca cacagaagcc agagccaggc acgcttggca gctgacacag     1860

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg cctgccttct     1920

ccaagaagcg aaggcggcgg aggctccgga ggaggcggct ctagagaagg acctgaactg     1980

agcccagacg accccgcagg gctgctggat ctgagacagg gaatgttcgc ccagctggtg     2040

gctcagaatg tgctgctgat tgatggaccc ctgtcctggt actccgaccc agggctggca     2100

ggggtgtccc tgactggcgg actgtcttac aaagaagata caaaagaact ggtggtggct     2160

aaagctgggg tgtactatgt gttttttcag ctggaactga ggcgggtggt ggctggggaa     2220

ggcagtggct ctgtgtccct ggcactgcat ctgcagcctc tgcgcagtgc tgcaggcgca     2280

gccgcactgg cactgactgt ggacctgccc ccagcttcca gcgaggctag aaacagcgcc     2340

ttcgggtttc aaggacgcct gctgcatctg agcgccggac agcgcctggg agtgcatctg     2400

catactgagg ctagggccag acatgcctgg cagctgaccc agggggcaac tgtgctggga     2460

ctgtttcgcg tgacacctga gatccccgct ggcctgccaa gccctagatc agaaggcgga     2520

gggggatcag ggggaggcgg atccagagag ggccctgagc tgagccccga tgatcctgct     2580

ggactgctgg acctgcggca gggcatgttt gctcagctgg tggcccagaa cgtgctgctg     2640

atcgatggcc ccctgtcctg gtacagcgat cctggactgg ctggcgtgtc actgacaggc     2700

ggcctgagct acaaagagga caccaaagaa ctggtggtgg ccaaggccgg cgtgtactac     2760

gtgttctttc agctggaact gcggagagtg gtggccggcg aaggatctgg ctctgtgtct     2820

ctggccctgc atctgcagcc tctgagaagc gctgctggcg ctgcagctct ggcactgaca     2880

gtggatctgc ctcctgccag ctccgaggcc cggaatagcg catttgggtt tcaaggcagg     2940

ctgctgcacc tgtctgccgg ccagaggctg ggagtgcatc tgcacacaga ggccagggct     3000

agacacgcct ggcagctgac acagggcgct acagtgctgg gcctgttcag agtgaccccc     3060

gagattccag ccggcctgcc ttctccaaga agcgaa                               3096


<210>  151
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti- CD19(8B8-018) light chain

<400>  151
gacatcgtca tgacccagac acccctgtcc ctctctgtga cccctggcca gccagcctca       60

attagctgca agtcctctca aagtctggag aaccccaatg ggaacactta ccttaattgg      120

tatctgcaga aacccggaca atcccctcaa ctcctgatct acagggtctc taagagattc      180

tcaggcgtgc cagatcgctt tagcggttcc gggtctggca cagacttcac cttgaagatt      240

agtcgggttg aagctgagga tgtgggagtc tattactgtc tgcagctcac tcatgtgccc      300

tacacctttg gtcagggcac aaaactggag atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccctccga cgagcagctg aagtccggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtgaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc cagccccgtg accaagtcct tcaaccgggg cgagtgc         657


<210>  152
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti- CD19(8B8-018) Fc hole chain

<400>  152

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Ala Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  153
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti- CD19(8B8-018) Fc knob chain fused to trimeric hu 4-1BBL 
       (71-254)

<400>  153

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Ser Ala Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
    450                 455                 460                 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
465                 470                 475                 480 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                485                 490                 495     


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
            500                 505                 510         


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
        515                 520                 525             


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
    530                 535                 540                 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
545                 550                 555                 560 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
                565                 570                 575     


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
            580                 585                 590         


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
        595                 600                 605             


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
    610                 615                 620                 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
625                 630                 635                 640 


Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu 
                645                 650                 655     


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
            660                 665                 670         


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
        675                 680                 685             


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
    690                 695                 700                 


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
705                 710                 715                 720 


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
                725                 730                 735     


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
            740                 745                 750         


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
        755                 760                 765             


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
    770                 775                 780                 


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
785                 790                 795                 800 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
                805                 810                 815     


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
            820                 825                 830         


Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        835                 840                 845             


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
    850                 855                 860                 


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
865                 870                 875                 880 


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                885                 890                 895     


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
            900                 905                 910         


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
        915                 920                 925             


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
    930                 935                 940                 


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
945                 950                 955                 960 


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
                965                 970                 975     


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
            980                 985                 990         


His Leu His Thr Glu Ala Arg Ala  Arg His Ala Trp Gln  Leu Thr Gln 
        995                 1000                 1005             


Gly Ala  Thr Val Leu Gly Leu  Phe Arg Val Thr Pro  Glu Ile Pro 
    1010                 1015                 1020             


Ala Gly  Leu Pro Ser Pro Arg  Ser Glu 
    1025                 1030         


<210>  154
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti- CD19(8B8-018) light chain

<400>  154

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Glu Asn Pro 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Leu 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  155
<211>  1353
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti- CD19(8B8-2B11) Fc hole chain

<400>  155
caggtgcaat tggttcaatc tggtgctgaa gtaaaaaaac cgggcgcttc cgttaaagtg       60

agctgcaaag catctggtta caccttcact gactatatca tgcactgggt tcgtcaggcc      120

ccgggccagg gtctggagtg gatgggctac attaacccat acaacgacgg ttccaaatat      180

accgagaaat tccagggccg cgtcacgatg accagcgaca cttctatctc caccgcgtac      240

atggaactgt ctagactgcg ttctgacgac accgctgttt actattgtgc acgcggtacc      300

tactactacg gtccacagct gtttgattac tggggccaag gtaccacggt gaccgtaagc      360

tctgctagca ccaagggccc ctccgtgttc cccctggccc ccagcagcaa gagcaccagc      420

ggcggcacag ccgctctggg ctgcctggtc aaggactact tccccgagcc cgtgaccgtg      480

tcctggaaca gcggagccct gacctccggc gtgcacacct tccccgccgt gctgcagagt      540

tctggcctgt atagcctgag cagcgtggtc accgtgcctt ctagcagcct gggcacccag      600

acctacatct gcaacgtgaa ccacaagccc agcaacacca aggtggacaa gaaggtggag      660

cccaagagct gcgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtgca ccctgccccc atcccgggat     1080

gagctgacca agaaccaggt cagcctctcg tgcgcagtca aaggcttcta tcccagcgac     1140

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1200

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg     1260

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1320

acgcagaaga gcctctccct gtctccgggt aaa                                  1353


<210>  156
<211>  3096
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti- CD19(8B8-2B11) Fc knob chain fused 
       to trimeric hu 4-1BBL (71-254)

<400>  156
caggtgcaat tggttcaatc tggtgctgaa gtaaaaaaac cgggcgcttc cgttaaagtg       60

agctgcaaag catctggtta caccttcact gactatatca tgcactgggt tcgtcaggcc      120

ccgggccagg gtctggagtg gatgggctac attaacccat acaacgacgg ttccaaatat      180

accgagaaat tccagggccg cgtcacgatg accagcgaca cttctatctc caccgcgtac      240

atggaactgt ctagactgcg ttctgacgac accgctgttt actattgtgc acgcggtacc      300

tactactacg gtccacagct gtttgattac tggggccaag gtaccacggt gaccgtaagc      360

tctgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct      420

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      480

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      540

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag      600

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gaaagttgag      660

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agctgcaggg      720

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      780

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      840

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      900

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      960

aaggagtaca agtgcaaggt ctccaacaaa gccctcggcg cccccatcga gaaaaccatc     1020

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc ctgcagagat     1080

gagctgacca agaaccaggt gtccctgtgg tgcctcgtga agggcttcta cccctccgat     1140

atcgccgtgg aatgggagag caacggccag cccgagaaca actacaagac caccccccct     1200

gtgctggaca gcgacggctc attcttcctg tactccaagc tgaccgtgga caagagccgg     1260

tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca caaccactac     1320

acccagaagt ccctgagcct gagccctggc ggaggcggag gatctggcgg gggaggatct     1380

agagagggcc ctgagctgtc ccccgatgat cctgctggac tgctggacct gcggcagggc     1440

atgtttgctc agctggtggc ccagaacgtg ctgctgatcg acggccctct gagctggtac     1500

agcgatcctg gactggctgg cgtgtcactg acaggcggcc tgagctacaa agaggacacc     1560

aaagaactgg tggtggccaa ggccggcgtg tactacgtgt tctttcagct ggaactgcgg     1620

agagtggtgg ccggcgaggg atctggatct gtgtctctgg ccctgcatct gcagcccctg     1680

agatcagctg ctggcgctgc tgctctggct ctgacagtgg atctgcctcc tgccagcagc     1740

gaggcccgga atagcgcatt tgggtttcaa ggcaggctgc tgcacctgtc tgccggccag     1800

aggctgggag tgcatctgca cacagaagcc agagccaggc acgcttggca gctgacacag     1860

ggcgctacag tgctgggcct gttcagagtg acccccgaga ttccagccgg cctgccttct     1920

ccaagaagcg aaggcggcgg aggctccgga ggaggcggct ctagagaagg acctgaactg     1980

agcccagacg accccgcagg gctgctggat ctgagacagg gaatgttcgc ccagctggtg     2040

gctcagaatg tgctgctgat tgatggaccc ctgtcctggt actccgaccc agggctggca     2100

ggggtgtccc tgactggcgg actgtcttac aaagaagata caaaagaact ggtggtggct     2160

aaagctgggg tgtactatgt gttttttcag ctggaactga ggcgggtggt ggctggggaa     2220

ggcagtggct ctgtgtccct ggcactgcat ctgcagcctc tgcgcagtgc tgcaggcgca     2280

gccgcactgg cactgactgt ggacctgccc ccagcttcca gcgaggctag aaacagcgcc     2340

ttcgggtttc aaggacgcct gctgcatctg agcgccggac agcgcctggg agtgcatctg     2400

catactgagg ctagggccag acatgcctgg cagctgaccc agggggcaac tgtgctggga     2460

ctgtttcgcg tgacacctga gatccccgct ggcctgccaa gccctagatc agaaggcgga     2520

gggggatcag ggggaggcgg atccagagag ggccctgagc tgagccccga tgatcctgct     2580

ggactgctgg acctgcggca gggcatgttt gctcagctgg tggcccagaa cgtgctgctg     2640

atcgatggcc ccctgtcctg gtacagcgat cctggactgg ctggcgtgtc actgacaggc     2700

ggcctgagct acaaagagga caccaaagaa ctggtggtgg ccaaggccgg cgtgtactac     2760

gtgttctttc agctggaact gcggagagtg gtggccggcg aaggatctgg ctctgtgtct     2820

ctggccctgc atctgcagcc tctgagaagc gctgctggcg ctgcagctct ggcactgaca     2880

gtggatctgc ctcctgccag ctccgaggcc cggaatagcg catttgggtt tcaaggcagg     2940

ctgctgcacc tgtctgccgg ccagaggctg ggagtgcatc tgcacacaga ggccagggct     3000

agacacgcct ggcagctgac acagggcgct acagtgctgg gcctgttcag agtgaccccc     3060

gagattccag ccggcctgcc ttctccaaga agcgaa                               3096


<210>  157
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of anti- CD19(8B8-2B11) light chain

<400>  157
gatattgtca tgactcaaac tccactgtct ctgtccgtga ccccgggtca gccagcgagc       60

atttcttgca aatccagcca atctctggaa acctccaccg gcaccacgta cctgaactgg      120

tatctccaga aaccgggtca gagcccgcag ctgctgatct accgtgtatc taagcgcttc      180

tccggcgttc ctgatcgttt cagcggttct ggatccggca ccgactttac tctgaaaatc      240

agccgtgtgg aagctgaaga cgttggcgtc tactattgtc tgcagctgct ggaagatcca      300

tacaccttcg gtcaaggaac gaaactggaa attaaacgta cggtggctgc accatctgtc      360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         657


<210>  158
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD19(8B8-2B11) Fc hole chain

<400>  158

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Pro Gln Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  159
<211>  1032
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti- CD19(8B8-2B11) Fc knob chain fused to trimeric hu 4-1BBL 
       (71-254)

<400>  159

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Ser Lys Tyr Thr Glu Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Ser Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Thr Tyr Tyr Tyr Gly Pro Gln Leu Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro 
    450                 455                 460                 


Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly 
465                 470                 475                 480 


Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro 
                485                 490                 495     


Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly 
            500                 505                 510         


Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala 
        515                 520                 525             


Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala 
    530                 535                 540                 


Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu 
545                 550                 555                 560 


Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro 
                565                 570                 575     


Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg 
            580                 585                 590         


Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr 
        595                 600                 605             


Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val 
    610                 615                 620                 


Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser 
625                 630                 635                 640 


Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu 
                645                 650                 655     


Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg 
            660                 665                 670         


Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp 
        675                 680                 685             


Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu 
    690                 695                 700                 


Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala 
705                 710                 715                 720 


Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val 
                725                 730                 735     


Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln 
            740                 745                 750         


Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp 
        755                 760                 765             


Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln 
    770                 775                 780                 


Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu 
785                 790                 795                 800 


His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala 
                805                 810                 815     


Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu 
            820                 825                 830         


Pro Ser Pro Arg Ser Glu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        835                 840                 845             


Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp 
    850                 855                 860                 


Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu 
865                 870                 875                 880 


Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val 
                885                 890                 895     


Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val 
            900                 905                 910         


Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg 
        915                 920                 925             


Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His 
    930                 935                 940                 


Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr 
945                 950                 955                 960 


Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly 
                965                 970                 975     


Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val 
            980                 985                 990         


His Leu His Thr Glu Ala Arg Ala  Arg His Ala Trp Gln  Leu Thr Gln 
        995                 1000                 1005             


Gly Ala  Thr Val Leu Gly Leu  Phe Arg Val Thr Pro  Glu Ile Pro 
    1010                 1015                 1020             


Ala Gly  Leu Pro Ser Pro Arg  Ser Glu 
    1025                 1030         


<210>  160
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti- CD19(8B8-2B11) light chain

<400>  160

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Glu Thr Ser 
            20                  25                  30          


Thr Gly Thr Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Leu Gln Leu 
                85                  90                  95      


Leu Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  161
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-L1 anti-CD19(8B8)

<400>  161

Asn Ser Asn Gly Asn Thr 
1               5       


<210>  162
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HVR-H2 anti-CD19(8B8)

<400>  162

Lys Phe Asn Gly 
1               


<210>  163
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Fc hole chain with HYRF mutation

<400>  163
gacaaaactc acacatgccc accgtgccca gcacctgaag ctgcaggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcggcgcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtgcacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctctcgtg cgcagtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accgcttcac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  164
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of human CD19 antigen Fc knob chain avi tag

<400>  164
cccgaggaac ccctggtcgt gaaggtggaa gagggcgaca atgccgtgct gcagtgcctg       60

aagggcacct ccgatggccc tacccagcag ctgacctggt ccagagagag ccccctgaag      120

cccttcctga agctgtctct gggcctgcct ggcctgggca tccatatgag gcctctggcc      180

atctggctgt tcatcttcaa cgtgtcccag cagatgggcg gcttctacct gtgtcagcct      240

ggccccccat ctgagaaggc ttggcagcct ggctggaccg tgaacgtgga aggatccggc      300

gagctgttcc ggtggaacgt gtccgatctg ggcggcctgg gatgcggcct gaagaacaga      360

tctagcgagg gccccagcag ccccagcggc aaactgatga gccccaagct gtacgtgtgg      420

gccaaggaca gacccgagat ctgggagggc gagcctcctt gcctgccccc tagagacagc      480

ctgaaccaga gcctgagcca ggacctgaca atggcccctg gcagcacact gtggctgagc      540

tgtggcgtgc cacccgactc tgtgtctaga ggccctctga gctggaccca cgtgcaccct      600

aagggcccta agagcctgct gagcctggaa ctgaaggacg acaggcccgc cagagatatg      660

tgggtcatgg aaaccggcct gctgctgcct agagccacag cccaggatgc cggcaagtac      720

tactgccaca gaggcaacct gaccatgagc ttccacctgg aaatcaccgc cagacccgtg      780

ctgtggcact ggctgctgag aacaggcggc tggaaggtcg acgctagcgg tggtagtccg      840

acacctccga cacccggggg tggttctgca gacaaaactc acacatgccc accgtgccca      900

gcacctgaag ccgcaggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc      960

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1020

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1080

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1140

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcggagcc     1200

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1260

ctgcccccat gccgggatga gctgaccaag aaccaggtca gcctgtggtg cctggtcaaa     1320

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1380

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaagctc     1440

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1500

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa atccggaggc     1560

ctgaacgaca tcttcgaggc ccagaagatt gaatggcacg ag                        1602


<210>  165
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc hole chain with HYRF mutation

<400>  165

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  166
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human CD19 antigen Fc knob chain avi tag

<400>  166

Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Thr 
            20                  25                  30          


Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile Trp Leu Phe 
    50                  55                  60                  


Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Asn Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser Leu Leu Ser 
        195                 200                 205             


Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp Val Met Glu 
    210                 215                 220                 


Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala Gly Lys Tyr 
225                 230                 235                 240 


Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu Glu Ile Thr 
                245                 250                 255     


Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly Gly Trp Lys 
            260                 265                 270         


Val Asp Ala Ser Gly Gly Ser Pro Thr Pro Pro Thr Pro Gly Gly Gly 
        275                 280                 285             


Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    290                 295                 300                 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
305                 310                 315                 320 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                325                 330                 335     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            340                 345                 350         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        355                 360                 365             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    370                 375                 380                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala 
385                 390                 395                 400 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                405                 410                 415     


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
            420                 425                 430         


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        435                 440                 445             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    450                 455                 460                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
465                 470                 475                 480 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                485                 490                 495     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            500                 505                 510         


Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln 
        515                 520                 525             


Lys Ile Glu Trp His Glu 
    530                 


<210>  167
<211>  1605
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of cynomolgus CD19 antigen Fc knob chain avi 
       tag

<400>  167
ccccaggaac ccctggtcgt gaaggtggaa gagggcgaca atgccgtgct ccagtgcctg       60

gaaggcacct ccgatggccc tacacagcag ctcgtgtggt gcagagacag ccccttcgag      120

cccttcctga acctgtctct gggcctgcct ggcatgggca tcagaatggg ccctctgggc      180

atctggctgc tgatcttcaa cgtgtccaac cagaccggcg gcttctacct gtgtcagcct      240

ggcctgccaa gcgagaaggc ttggcagcct ggatggaccg tgtccgtgga aggatctggc      300

gagctgttcc ggtggaacgt gtccgatctg ggcggcctgg gatgcggcct gaagaacaga      360

agcagcgagg gccctagcag ccccagcggc aagctgaata gcagccagct gtacgtgtgg      420

gccaaggaca gacccgagat gtgggagggc gagcctgtgt gtggcccccc tagagatagc      480

ctgaaccaga gcctgagcca ggacctgaca atggcccctg gcagcacact gtggctgagc      540

tgtggcgtgc cacccgactc tgtgtccaga ggccctctga gctggacaca cgtgcggcca      600

aagggcccta agagcagcct gctgagcctg gaactgaagg acgaccggcc cgaccgggat      660

atgtgggtgg tggatacagg cctgctgctg accagagcca cagcccagga tgccggcaag      720

tactactgcc acagaggcaa ctggaccaag agcttttacc tggaaatcac cgccagaccc      780

gccctgtggc actggctgct gagaatcgga ggctggaagg tcgacgctag cggtggtagt      840

ccgacacctc cgacacccgg gggtggttct gcagacaaaa ctcacacatg cccaccgtgc      900

ccagcacctg aagccgcagg gggaccgtca gtcttcctct tccccccaaa acccaaggac      960

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     1020

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     1080

aagccgcggg aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg     1140

caccaggact ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctcgga     1200

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     1260

accctgcccc catgccggga tgagctgacc aagaaccagg tcagcctgtg gtgcctggtc     1320

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     1380

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     1440

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     1500

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaatccgga     1560

ggcctgaacg acatcttcga ggcccagaag attgaatggc acgag                     1605


<210>  168
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cynomolgus CD19 antigen Fc knob chain avi tag

<400>  168

Pro Gln Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp Asn Ala Val 
1               5                   10                  15      


Leu Gln Cys Leu Glu Gly Thr Ser Asp Gly Pro Thr Gln Gln Leu Val 
            20                  25                  30          


Trp Cys Arg Asp Ser Pro Phe Glu Pro Phe Leu Asn Leu Ser Leu Gly 
        35                  40                  45              


Leu Pro Gly Met Gly Ile Arg Met Gly Pro Leu Gly Ile Trp Leu Leu 
    50                  55                  60                  


Ile Phe Asn Val Ser Asn Gln Thr Gly Gly Phe Tyr Leu Cys Gln Pro 
65                  70                  75                  80  


Gly Leu Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr Val Ser Val 
                85                  90                  95      


Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp Leu Gly Gly 
            100                 105                 110         


Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro Ser Ser Pro 
        115                 120                 125             


Ser Gly Lys Leu Asn Ser Ser Gln Leu Tyr Val Trp Ala Lys Asp Arg 
    130                 135                 140                 


Pro Glu Met Trp Glu Gly Glu Pro Val Cys Gly Pro Pro Arg Asp Ser 
145                 150                 155                 160 


Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro Gly Ser Thr 
                165                 170                 175     


Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser Arg Gly Pro 
            180                 185                 190         


Leu Ser Trp Thr His Val Arg Pro Lys Gly Pro Lys Ser Ser Leu Leu 
        195                 200                 205             


Ser Leu Glu Leu Lys Asp Asp Arg Pro Asp Arg Asp Met Trp Val Val 
    210                 215                 220                 


Asp Thr Gly Leu Leu Leu Thr Arg Ala Thr Ala Gln Asp Ala Gly Lys 
225                 230                 235                 240 


Tyr Tyr Cys His Arg Gly Asn Trp Thr Lys Ser Phe Tyr Leu Glu Ile 
                245                 250                 255     


Thr Ala Arg Pro Ala Leu Trp His Trp Leu Leu Arg Ile Gly Gly Trp 
            260                 265                 270         


Lys Val Asp Ala Ser Gly Gly Ser Pro Thr Pro Pro Thr Pro Gly Gly 
        275                 280                 285             


Gly Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    290                 295                 300                 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
305                 310                 315                 320 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                325                 330                 335     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            340                 345                 350         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        355                 360                 365             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    370                 375                 380                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly 
385                 390                 395                 400 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                405                 410                 415     


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
            420                 425                 430         


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        435                 440                 445             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    450                 455                 460                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
465                 470                 475                 480 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                485                 490                 495     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            500                 505                 510         


Ser Leu Ser Pro Gly Lys Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala 
        515                 520                 525             


Gln Lys Ile Glu Trp His Glu 
    530                 535 


<210>  169
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence CD19 (8B8) VH Parental clone

<400>  169
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

gcctgcaagg cttctggata cacattcact gactatatta tgcactgggt gaagcagaag      120

actgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg ttctaagtac      180

actgagaagt tcaacggcaa ggccacactg acttcagaca aatcttccat cacagcctac      240

atggagctca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagagggacc      300

tattattatg gtagcgccct ctttgactac tggggccaag gcaccactct cacagtctcc      360

tcg                                                                    363


<210>  170
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence CD19 (8B8) VL Parental clone

<400>  170
gatgctgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca ggtctagtca gagccttgaa aacagtaatg gaaacaccta tttgaactgg      120

tacctccaga aaccaggcca gtctccacaa ctcctgatct acagggtttc caaacgattt      180

tctggggtcc tagacaggtt cagtggtagt ggatcaggga cagatttcac actgaaaatc      240

agcagagtgg aggctgagga tttgggagtt tatttctgcc tacaacttac acatgtcccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  171
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  43-45: 40% Y, 6% A/S/T/G/P/D/N/E/Q/V, 49-51: 40% N, 6%  
       A/S/T/Y/G/P/D/E/Q/V, 55-57: 25% S/T/Q/E, 61-63: 25% S/T/Q/E


<220>
<221>  misc_feature
<222>  (43)..(45)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (55)..(57)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  n is a, c, g or t

<400>  171
cagctgcggg ctctgacccg gtttctggag ataccagttc agnnncgtnn ngccnnngga       60

nnnttccaga gattggctgg atttgcaaga aatg                                   94


<210>  172
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40-42: 30% R, 20% E, 5% A/S/T/Y/G/P/D/N/Q/V. 49-51: 30% K, 20% 
       S,

       5% A/N/T/Y/G/P/D/E/Q/V, 55-57: 40% F, 5% 
       A/S/T/Y/G/P/D/E/Q/V/I/L,

       


<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (55)..(57)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (58)..(60)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (67)..(69)
<223>  n is a, c, g or t

<400>  172
ctccagaaac cgggtcagag cccgcagctg ctgatctacn nngtatctnn ncgcnnnnnn       60

ggcgttnnng atcgtttcag cggttctgga tccggcacc                              99


<210>  173
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  40-42: 52% H, 4% G/A/S/P/T/N/Y/D/E/Q/V/I, 46-48: 30% I, 15% Y, 5%
       G/A/S/T/P/N/H/D/E/Q/V, 49-51: 52% Y, 4% G/A/S/P/T/N/H/D/E/Q/V/I, 
       52-54: 30% D, 15% G, 5% A/S/P/Y/N/H/D/E/Q/V/I, 55-57: 52% T, 4% 

       G/A/S/P/Y/N/H/D/E/Q/V/I, 61-63: 52% T, 4% G/A/S/P/Y/N/H/D/E/


<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (55)..(57)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  n is a, c, g or t

<400>  173
catccactcc agaccctggc ccggggcctg acgaacccan nncatnnnnn nnnnnnngaa       60

nnngtaacca gatgctttgc agctcacttt aacggaagc                              99


<210>  174
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34-36: 45% Y, 5% others, 40-42: 52% N, 4% others, 46-48: 40% Y,5%
       others, 49-51: 30% N, 15% S, 5% others, 52-54: 30% D, 15% G,5% 
       others,  55-57: 52% G, 4% others, 61-63: 30% K, 15% N, 4% others,
       70-72: 30% E, 15% Q, 5% others


<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (52)..(54)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (55)..(57)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (61)..(63)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (70)..(72)
<223>  n is a, c, g or t

<400>  174
caggccccgg gccagggtct ggagtggatg ggcnnnattn nnccannnnn nnnnnnntcc       60

nnntataccn nnaaattcca gggccgcgtc acgatgacc                              99


<210>  175
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 H3 reverse constant

<400>  175
cgtcaccggt tcggggaagt agtccttgac cag                                    33


<210>  176
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LMB3

<400>  176
caggaaacag ctatgaccat gattac                                            26


<210>  177
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 L1 forward constant

<400>  177
tggtatctcc agaaaccggg tcagagcccg cag                                    33


<210>  178
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34-36: 52% Y, 4% others, 37-39: 52% P, 4% others, 40-42: 42% 
       V,10% L, 4% others, 43-45: 52% H, 4% others, 46-48: 42% T, 10% I,
       4% others, 49-51: 45% L, 11% G, 4% others


<220>
<221>  misc_feature
<222>  (34)..(36)
<223>  n is a,c,g or t

<220>
<221>  misc_feature
<222>  (37)..(39)
<223>  n is a,c,g or t

<220>
<221>  misc_feature
<222>  (40)..(42)
<223>  n is a,c,g or t

<220>
<221>  misc_feature
<222>  (43)..(45)
<223>  n is a,c,g or t

<220>
<221>  misc_feature
<222>  (46)..(48)
<223>  n is a,c,g or t

<220>
<221>  misc_feature
<222>  (49)..(51)
<223>  n is a,c,g or t

<400>  178
tttaatttcc agtttagttc cttgaccgaa ggtnnnnnnn nnnnnnnnnn nctgcagaca       60

atagtagacg ccaacgtctt cagc                                              84


<210>  179
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD19 L3 forward constant

<400>  179
accttcggtc aaggaactaa actggaaatt aaacg                                  35


<210>  180
<211>  107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pos. 59-61: 50% L, 3.8% others, 62-64: 50% A, 4.2% others, 
       65-67:50% S, 4.2% others, 68-70: 50% G, 4.2% others, 71-73: 50% 
       Y, 4.2%others, 74-76: 50% Y, 4.2% others, 77-79: 50% Y, 4.2% 
       others, 80-82: 50% T, 4.2% others, 83-85: 50% G, 4.2% others.


<220>
<221>  misc_feature
<222>  (54)..(58)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (59)..(61)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (62)..(64)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (65)..(67)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (68)..(70)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (71)..(73)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (74)..(76)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (77)..(79)
<223>  n is a, c, g or t

<220>
<221>  misc_feature
<222>  (80)..(82)
<223>  n is a, c, g or t

<400>  180
ttggtgctag cagagcttac ggtcaccgtg gtaccttggc cccagtaatc aaannnnnnn       60

nnnnnnnnnn nnnnnnnnnn gcgtgcacaa tagtaaacag cggtgtc                    107


<210>  181
<211>  3078
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of DP47 Fc knob fused to trimeric hu 4-1BBL 
       (71-254)

<400>  181
gaggtgcaat tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagc agttatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtat attactgtgc gaaaggcagc      300

ggatttgact actggggcca aggaaccctg gtcaccgtct cgagtgctag caccaagggc      360

ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg      420

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      480

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      540

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg      600

aatcacaagc ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa      660

actcacacat gcccaccgtg cccagcacct gaagctgcag ggggaccgtc agtcttcctc      720

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg      780

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg      840

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg      900

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag      960

gtctccaaca aagccctcgg cgcccccatc gagaaaacca tctccaaagc caaagggcag     1020

ccccgagaac cacaggtgta caccctgccc ccctgcagag atgagctgac caagaaccag     1080

gtgtccctgt ggtgcctcgt gaagggcttc tacccctccg atatcgccgt ggaatgggag     1140

agcaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1200

tcattcttcc tgtactccaa gctgaccgtg gacaagagcc ggtggcagca gggcaacgtg     1260

ttcagctgca gcgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgagc     1320

ctgagccctg gcggaggcgg aggatctggc gggggaggat ctagagaggg ccctgagctg     1380

tcccccgatg atcctgctgg actgctggac ctgcggcagg gcatgtttgc tcagctggtg     1440

gcccagaacg tgctgctgat cgacggccct ctgagctggt acagcgatcc tggactggct     1500

ggcgtgtcac tgacaggcgg cctgagctac aaagaggaca ccaaagaact ggtggtggcc     1560

aaggccggcg tgtactacgt gttctttcag ctggaactgc ggagagtggt ggccggcgag     1620

ggatctggat ctgtgtctct ggccctgcat ctgcagcccc tgagatcagc tgctggcgct     1680

gctgctctgg ctctgacagt ggatctgcct cctgccagca gcgaggcccg gaatagcgca     1740

tttgggtttc aaggcaggct gctgcacctg tctgccggcc agaggctggg agtgcatctg     1800

cacacagaag ccagagccag gcacgcttgg cagctgacac agggcgctac agtgctgggc     1860

ctgttcagag tgacccccga gattccagcc ggcctgcctt ctccaagaag cgaaggcggc     1920

ggaggctccg gaggaggcgg ctctagagaa ggacctgaac tgagcccaga cgaccccgca     1980

gggctgctgg atctgagaca gggaatgttc gcccagctgg tggctcagaa tgtgctgctg     2040

attgatggac ccctgtcctg gtactccgac ccagggctgg caggggtgtc cctgactggc     2100

ggactgtctt acaaagaaga tacaaaagaa ctggtggtgg ctaaagctgg ggtgtactat     2160

gtgttttttc agctggaact gaggcgggtg gtggctgggg aaggcagtgg ctctgtgtcc     2220

ctggcactgc atctgcagcc tctgcgcagt gctgcaggcg cagccgcact ggcactgact     2280

gtggacctgc ccccagcttc cagcgaggct agaaacagcg ccttcgggtt tcaaggacgc     2340

ctgctgcatc tgagcgccgg acagcgcctg ggagtgcatc tgcatactga ggctagggcc     2400

agacatgcct ggcagctgac ccagggggca actgtgctgg gactgtttcg cgtgacacct     2460

gagatccccg ctggcctgcc aagccctaga tcagaaggcg gagggggatc agggggaggc     2520

ggatccagag agggccctga gctgagcccc gatgatcctg ctggactgct ggacctgcgg     2580

cagggcatgt ttgctcagct ggtggcccag aacgtgctgc tgatcgatgg ccccctgtcc     2640

tggtacagcg atcctggact ggctggcgtg tcactgacag gcggcctgag ctacaaagag     2700

gacaccaaag aactggtggt ggccaaggcc ggcgtgtact acgtgttctt tcagctggaa     2760

ctgcggagag tggtggccgg cgaaggatct ggctctgtgt ctctggccct gcatctgcag     2820

cctctgagaa gcgctgctgg cgctgcagct ctggcactga cagtggatct gcctcctgcc     2880

agctccgagg cccggaatag cgcatttggg tttcaaggca ggctgctgca cctgtctgcc     2940

ggccagaggc tgggagtgca tctgcacaca gaggccaggg ctagacacgc ctggcagctg     3000

acacagggcg ctacagtgct gggcctgttc agagtgaccc ccgagattcc agccggcctg     3060

ccttctccaa gaagcgaa                                                   3078


<210>  182
<211>  1026
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DP47 Fc knob fused to trimeric hu 4-1BBL (71-254)

<400>  182

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Gly Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
    450                 455                 460                 


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
465                 470                 475                 480 


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
                485                 490                 495     


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
            500                 505                 510         


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
        515                 520                 525             


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
    530                 535                 540                 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
545                 550                 555                 560 


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
                565                 570                 575     


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
            580                 585                 590         


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
        595                 600                 605             


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
    610                 615                 620                 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro 
                645                 650                 655     


Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln 
            660                 665                 670         


Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr 
        675                 680                 685             


Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr 
    690                 695                 700                 


Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr 
705                 710                 715                 720 


Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser 
                725                 730                 735     


Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala 
            740                 745                 750         


Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser 
        755                 760                 765             


Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu 
    770                 775                 780                 


Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala 
785                 790                 795                 800 


Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe 
                805                 810                 815     


Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
            820                 825                 830         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu 
        835                 840                 845             


Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe 
    850                 855                 860                 


Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser 
865                 870                 875                 880 


Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu 
                885                 890                 895     


Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val 
            900                 905                 910         


Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu 
        915                 920                 925             


Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser 
    930                 935                 940                 


Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala 
945                 950                 955                 960 


Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu 
                965                 970                 975     


His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala 
            980                 985                 990         


Arg Ala Arg His Ala Trp Gln Leu  Thr Gln Gly Ala Thr  Val Leu Gly 
        995                 1000                 1005             


Leu Phe  Arg Val Thr Pro Glu  Ile Pro Ala Gly Leu  Pro Ser Pro 
    1010                 1015                 1020             


Arg Ser  Glu 
    1025     


<210>  183
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMV derived peptide

<400>  183

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


