               SEQUENCE LISTING

<110> Molecular Partners AG

<120> RECOMBINANT BINDING PROTEINS AND THEIR USE

<130> MD41211

<150> EP 15 162 502 
<151> 2015-04-02

<150> EP 15 162 511 
<151> 2015-04-02

<160> 181

<170> BiSSAP 1.3

<210> 1
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> His-tag

<400> 1
Met Arg Gly Ser His His His His His His Gly Ser 
1               5                   10          

<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> GS-linker

<400> 2
Gly Gly Gly Gly Ser 
1               5   

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> GS-linker

<400> 3
Gly Gly Gly Gly Ser Gly Ser 
1               5           

<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Polypeptide linker

<400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
1               5                   10          

<210> 5
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> GS-linker

<400> 5
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Ser 
    

<210> 6
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> GS-linker

<400> 6
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      
Gly Gly Gly Ser Gly Ser 
            20          

<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> PT-linker

<400> 7
Gly Ser Pro Thr Pro Thr Pro Thr Gly Ser 
1               5                   10  

<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> PT-linker

<400> 8
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly 
1               5                   10                  15      
Ser 
    

<210> 9
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> PT-linker

<400> 9
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
1               5                   10                  15      
Pro Thr Pro Thr Pro Thr Gly Ser 
            20                  

<210> 10
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 10
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Thr Asp 
            20                  25                  30          
Asn Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Ser Asn Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  
Asp Leu Thr Gly Ile Thr Pro Leu His Leu Ala Ala Ala Thr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Tyr Asp Asn Asp Gly His Thr Pro Leu His Leu Ala Ala Lys Tyr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 11
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 11
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Arg Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 12
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 12
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Phe Asp 
            20                  25                  30          
Trp Met Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Thr 
    50                  55                  60                  
Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Thr 
                85                  90                  95      
Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 13
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 13
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 14
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 14
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr Ala Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala His 
    50                  55                  60                  
Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Thr Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 15
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 15
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr Ala Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Val Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ile Gly His 
65                  70                  75                  80  
Gln Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 16
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 16
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Tyr Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 17
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 17
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Arg Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 18
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 18
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 19
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 19
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 20
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 20
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 21
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 21
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 22
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 22
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 23
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 23
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Phe Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Trp Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Met Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Met Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 24
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 24
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Phe Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Trp Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Phe Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 25
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 25
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 26
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 26
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 27
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 27
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ala Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 28
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 28
Asp Leu Gly Met Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala His Asp 
            20                  25                  30          
Thr Trp Gly Leu Thr Pro Leu His Leu Ala Ala Phe His Gly His Gln 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln 
    50                  55                  60                  
Asp Phe Tyr Gly Lys Thr Pro Leu His Leu Ala Ala Leu Arg Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Gln Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 29
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 29
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Tyr 
            20                  25                  30          
Glu Asp Gly Leu Thr Pro Leu His Leu Ala Ala Phe Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Thr 
    50                  55                  60                  
Asp Ala Trp Gly His Thr Pro Leu His Leu Ala Ala Tyr Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Thr 
                85                  90                  95      
His Asp Lys Glu Gly Met Thr Ala Leu His Leu Ala Ala Leu Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 30
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 30
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Thr His Asp 
            20                  25                  30          
Asn Phe Gly Asp Thr Pro Leu His Leu Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Phe 
    50                  55                  60                  
Asp Ser Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Leu Asp Tyr Asn Gly Asn Thr Pro Leu His Leu Ala Ala Asn Ser Gly 
            100                 105                 110         
Arg Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 31
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 31
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Val Asp 
            20                  25                  30          
Ala Trp Gly Asp Thr Pro Leu His Leu Ala Ala Ser Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Ala 
    50                  55                  60                  
Asp Tyr Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Ser Ala Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Asp Asn Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
Arg Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 32
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 32
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ile Asp 
            20                  25                  30          
Thr Trp Gly Asn Thr Pro Leu His Leu Ala Ala Asp Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Leu 
    50                  55                  60                  
Asp Trp Phe Gly Asp Thr Pro Leu His Leu Ala Ala Ser Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Val Asp Thr Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
Arg Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 33
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 33
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Gln Asp 
            20                  25                  30          
Arg Trp Gly Asp Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Asp 
    50                  55                  60                  
Asp Val Phe Gly Asp Thr Pro Leu His Leu Ala Ala Ser Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Asp Asp Tyr Ala Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 34
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 34
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Gln Asp 
            20                  25                  30          
Arg Trp Gly Asp Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Asp 
    50                  55                  60                  
Asp Val Phe Gly Asp Thr Pro Leu His Leu Ala Ala Ser Leu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Asp Asp Tyr Ala Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 35
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 35
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Asn Asp 
            20                  25                  30          
Phe Leu Gly Leu Thr Pro Leu His Leu Ala Ala Ser Thr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ile 
    50                  55                  60                  
Asp Ala Tyr Gly His Thr Pro Leu His Leu Ala Ala Asn Asn Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Ile Asp His Phe Gly Tyr Thr Pro Leu His Leu Ala Ala Met Phe Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 36
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 36
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Asn Asp 
            20                  25                  30          
Ser Ser Gly Leu Thr Pro Leu His Leu Ala Ala Phe Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Asp 
    50                  55                  60                  
Asp Asp Trp Gly His Thr Pro Leu His Leu Ala Ala His Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Ile Asp Thr Arg Gly Leu Thr Pro Leu His Leu Ala Ala Ile Ala Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 37
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 37
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ser Asp 
            20                  25                  30          
Asp Thr Gly Leu Thr Pro Leu His Leu Ala Ala Asn Arg Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Asn 
    50                  55                  60                  
Asp Phe Ala Gly Met Thr Pro Leu His Leu Ala Ala Asn Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala 
                85                  90                  95      
His Asp Asp Tyr Gly Leu Thr Pro Leu His Leu Ala Ala Asn Trp Arg 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 38
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 38
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala Ile Trp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Lys Leu Arg 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 39
<211> 157
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 39
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Leu Asp 
            20                  25                  30          
Gln Ile Gly Trp Thr Pro Leu His Leu Ala Ala Asn Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Leu Trp Gly Gln Thr Pro Leu His Leu Ala Ala Trp Lys Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Thr Asp Gly Leu Thr Pro Leu His Leu Ala Ala Ile Arg Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155         

<210> 40
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 40
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Ser Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asp Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asp Ala Ser 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Asp Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 41
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 41
Asp Leu Gly Lys Glu Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          
Tyr Phe Gly His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Ala Phe Glu Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 42
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 42
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          
Tyr Phe Gly His Thr Pro Leu His Leu Ala Ala Arg Asp Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 43
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 43
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asp Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Ser 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 44
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 44
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 45
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 45
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 46
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 46
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 47
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 47
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 48
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 48
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 49
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 49
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 50
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 50
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 51
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 51
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 52
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 52
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 53
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 53
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Phe Leu Met Ala Asn Gly Ala Asp Val Asn Ala Ala Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Asn Gly Ala Asp Val Asn Ala Gln 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
        115                 120                 

<210> 54
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 54
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 55
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 55
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 56
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain

<400> 56
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 

<210> 57
<211> 159
<212> PRT
<213> Artificial Sequence

<220> 
<223> Designed ankyrin repeat domain with a C-terminal polypeptide
      linker

<400> 57
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Asp Ile Thr Gly Leu Lys Leu Asn 
145                 150                 155                 

<210> 58
<211> 302
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 58
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His 
            180                 185                 190         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr 
                245                 250                 255     
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
        275                 280                 285             
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
    290                 295                 300         

<210> 59
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 59
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His 
            180                 185                 190         
Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
                245                 250                 255     
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
            260                 265                 

<210> 60
<211> 305
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 60
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala 
305 

<210> 61
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 61
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 62
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 62
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
                245                 250                 255     
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
            260                 265                 270         
Asn 
    

<210> 63
<211> 269
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 63
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His 
            180                 185                 190         
Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala 
                245                 250                 255     
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
            260                 265                 

<210> 64
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 64
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Pro Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                245                 250                 255     
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
            260                 265                 270         
Asn 
    

<210> 65
<211> 273
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 65
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                245                 250                 255     
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
            260                 265                 270         
Asn 
    

<210> 66
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 66
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
                245                 250                 255     
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 67
<211> 272
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising two designed ankyrin repeat domains

<400> 67
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         



<210> 68
<211> 488
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 68
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu 
                245                 250                 255     
Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
            260                 265                 270         
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
        275                 280                 285             
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
    290                 295                 300                 
Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly 
            420                 425                 430         
Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
    450                 455                 460                 
Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
465                 470                 475                 480 
Ala Glu Ile Leu Gln Lys Leu Asn 
                485             

<210> 69
<211> 488
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 69
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
His Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ala Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu 
                245                 250                 255     
Ser Ala Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
            260                 265                 270         
Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp 
        275                 280                 285             
Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys 
    290                 295                 300                 
Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly 
            420                 425                 430         
Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser 
    450                 455                 460                 
Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile 
465                 470                 475                 480 
Ala Glu Val Leu Gln Lys Leu Asn 
                485             

<210> 70
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 70
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ala Gly His 
            180                 185                 190         
Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Ala Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr 
                245                 250                 255     
Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
        275                 280                 285             
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 
Ser Arg Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
                325                 330                 335     
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
            340                 345                 350         
Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu 
        355                 360                 365             
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
    370                 375                 380                 
Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala 
385                 390                 395                 400 
Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
                405                 410                 415     
Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala 
            420                 425                 430         
Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        435                 440                 445             
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
    450                 455                 460                 
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
465                 470                 475                 480 



<210> 71
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 71
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly His 
            180                 185                 190         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp Leu 
                245                 250                 255     
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
        275                 280                 285             
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 
Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
                325                 330                 335     
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
            340                 345                 350         
Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ala 
        355                 360                 365             
Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
    370                 375                 380                 
Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser 
385                 390                 395                 400 
Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
                405                 410                 415     
Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala Ala 
            420                 425                 430         
Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        435                 440                 445             
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
    450                 455                 460                 
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
465                 470                 475                 480 



<210> 72
<211> 455
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 72
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu 
                245                 250                 255     
Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
            260                 265                 270         
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
        275                 280                 285             
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
    290                 295                 300                 
Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Leu Asn 
    450                 455 

<210> 73
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 73
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Pro Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                245                 250                 255     
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
305                 310                 315                 320 
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Leu Asn 
            420         

<210> 74
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 74
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
                245                 250                 255     
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
305                 310                 315                 320 
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Pro Trp Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
                405                 410                 415     
Ile Leu Gln Lys Leu Asn 
            420         

<210> 75
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 75
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                245                 250                 255     
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
305                 310                 315                 320 
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Leu Asn 
            420         

<210> 76
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 76
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
                245                 250                 255     
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
305                 310                 315                 320 
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Arg Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
                405                 410                 415     
Ile Leu Gln Lys Leu Asn 
            420         

<210> 77
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 77
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val 
            180                 185                 190         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp 
    210                 215                 220                 
Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Pro Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala 
385                 390                 395                 400 
Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu 
                405                 410                 415     
Gln Lys Ala Ala 
            420 

<210> 78
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 78
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
                245                 250                 255     
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu 
        355                 360                 365             
His Leu Ala Asp Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro 
385                 390                 395                 400 
Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
                405                 410                 415     
Gln Lys Ala Ala 
            420 

<210> 79
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 79
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro 
385                 390                 395                 400 
Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
                405                 410                 415     
Gln Lys Ala Ala 
            420 

<210> 80
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 80
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
                245                 250                 255     
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro 
385                 390                 395                 400 
Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
                405                 410                 415     
Gln Lys Ala Ala 
            420 

<210> 81
<211> 420
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 81
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Pro Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala 
385                 390                 395                 400 
Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu 
                405                 410                 415     
Gln Lys Ala Ala 
            420 

<210> 82
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 82
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Arg Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
                245                 250                 255     
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
305                 310                 315                 320 
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Arg Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
                405                 410                 415     
Ile Leu Gln Lys Leu Asn 
            420         

<210> 83
<211> 486
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 83
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Phe Gly His Leu Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ile Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Lys Leu Arg His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
        275                 280                 285             
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Leu Asp Gln Ile Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Asn Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Trp Gly Gln Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Trp Lys Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Thr Asp Gly Leu Thr 
            420                 425                 430         
Pro Leu His Leu Ala Ala Ile Arg Gly His Leu Glu Ile Val Glu Val 
        435                 440                 445             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys 
    450                 455                 460                 
Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
465                 470                 475                 480 
Val Leu Gln Lys Ala Ala 
                485     

<210> 84
<211> 486
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 84
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala Ile Trp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Lys Leu Arg 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Leu Asp Gln Ile Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Leu Trp Gly Gln Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Trp Lys Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Lys Asp Thr Asp Gly Leu Thr Pro Leu His Leu 
        275                 280                 285             
Ala Ala Ile Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
    290                 295                 300                 
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
305                 310                 315                 320 
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
                325                 330                 335     
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
            340                 345                 350         
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
        355                 360                 365             
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
            420                 425                 430         
Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val 
        435                 440                 445             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
    450                 455                 460                 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
465                 470                 475                 480 
Val Leu Gln Lys Ala Ala 
                485     

<210> 85
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 85
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 86
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 86
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
145                 150                 155                 160 
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                165                 170                 175     
Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly 
            180                 185                 190         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        195                 200                 205             
Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr 
    210                 215                 220                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
225                 230                 235                 240 
Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn 
                245                 250                 255     
Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
            260                 265                 270         
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
        275                 280                 285             
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
    290                 295                 300                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 
Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
                325                 330                 335     
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
            340                 345                 350         
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
        355                 360                 365             
Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
    370                 375                 380                 
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
385                 390                 395                 400 
Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
                405                 410                 415     
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
            420                 425                 430         
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
        435                 440                 445             
Ala 
    

<210> 87
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 87
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 88
<211> 480
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 88
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly His 
            180                 185                 190         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp Leu 
                245                 250                 255     
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
        275                 280                 285             
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 
Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
                325                 330                 335     
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
            340                 345                 350         
Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ala 
        355                 360                 365             
Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
    370                 375                 380                 
Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser 
385                 390                 395                 400 
Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
                405                 410                 415     
Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala Ala 
            420                 425                 430         
Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        435                 440                 445             
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
    450                 455                 460                 
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
465                 470                 475                 480 



<210> 89
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 89
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 90
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 90
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 91
<211> 449
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 91
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
145                 150                 155                 160 
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                165                 170                 175     
Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly 
            180                 185                 190         
His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        195                 200                 205             
Ala Lys Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val 
    210                 215                 220                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
225                 230                 235                 240 
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
                245                 250                 255     
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
    290                 295                 300                 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
305                 310                 315                 320 
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
                325                 330                 335     
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
            340                 345                 350         
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
        355                 360                 365             
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
    370                 375                 380                 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
385                 390                 395                 400 
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
                405                 410                 415     
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
            420                 425                 430         
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
        435                 440                 445             
Ala 
    

<210> 92
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 92
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 93
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 93
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 94
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising three designed ankyrin repeat domains

<400> 94
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            340                 345                 350         
Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala 
    450             

<210> 95
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 95
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 96
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 96
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 97
<211> 637
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 97
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu 
                245                 250                 255     
Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
            260                 265                 270         
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
        275                 280                 285             
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
    290                 295                 300                 
Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly 
            420                 425                 430         
Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
    450                 455                 460                 
Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
465                 470                 475                 480 
Ala Glu Ile Leu Gln Lys Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr 
                485                 490                 495     
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg 
            500                 505                 510         
Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
        515                 520                 525             
Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys 
    530                 535                 540                 
Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His 
545                 550                 555                 560 
Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                565                 570                 575     
Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly 
            580                 585                 590         
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        595                 600                 605             
Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala 
    610                 615                 620                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
625                 630                 635         

<210> 98
<211> 637
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 98
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
His Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Ala Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu 
                245                 250                 255     
Ser Ala Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
            260                 265                 270         
Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp 
        275                 280                 285             
Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys 
    290                 295                 300                 
Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly 
            420                 425                 430         
Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser 
    450                 455                 460                 
Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile 
465                 470                 475                 480 
Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr 
                485                 490                 495     
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg 
            500                 505                 510         
Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
        515                 520                 525             
Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys 
    530                 535                 540                 
Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His 
545                 550                 555                 560 
Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                565                 570                 575     
Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly 
            580                 585                 590         
His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn 
        595                 600                 605             
Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala 
    610                 615                 620                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
625                 630                 635         

<210> 99
<211> 625
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 99
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ala Gly His 
            180                 185                 190         
Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Ala Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr 
                245                 250                 255     
Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
        275                 280                 285             
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 
Ser Arg Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
                325                 330                 335     
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
            340                 345                 350         
Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu 
        355                 360                 365             
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
    370                 375                 380                 
Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala 
385                 390                 395                 400 
Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
                405                 410                 415     
Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala 
            420                 425                 430         
Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        435                 440                 445             
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
    450                 455                 460                 
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Gly 
465                 470                 475                 480 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     
Gly Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
            500                 505                 510         
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
        515                 520                 525             
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
    530                 535                 540                 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
545                 550                 555                 560 
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
                565                 570                 575     
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
            580                 585                 590         
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
        595                 600                 605             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
    610                 615                 620                 
Asn 
625 

<210> 100
<211> 625
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 100
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Gly Gly Gly Ser 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg 
    130                 135                 140                 
Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp 
145                 150                 155                 160 
Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                165                 170                 175     
Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly His 
            180                 185                 190         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        195                 200                 205             
Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly 
    210                 215                 220                 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
225                 230                 235                 240 
Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp Leu 
                245                 250                 255     
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
            260                 265                 270         
Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp 
        275                 280                 285             
Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Gly Gly Gly 
    290                 295                 300                 
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 
Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
                325                 330                 335     
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
            340                 345                 350         
Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ala 
        355                 360                 365             
Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
    370                 375                 380                 
Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser 
385                 390                 395                 400 
Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
                405                 410                 415     
Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala Ala 
            420                 425                 430         
Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        435                 440                 445             
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
    450                 455                 460                 
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly 
465                 470                 475                 480 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     
Gly Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
            500                 505                 510         
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
        515                 520                 525             
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
    530                 535                 540                 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
545                 550                 555                 560 
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
                565                 570                 575     
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
            580                 585                 590         
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
        595                 600                 605             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
    610                 615                 620                 
Asn 
625 

<210> 101
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 101
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
145                 150                 155                 160 
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                165                 170                 175     
Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly 
            180                 185                 190         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        195                 200                 205             
Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr 
    210                 215                 220                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
225                 230                 235                 240 
Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn 
                245                 250                 255     
Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
            260                 265                 270         
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
        275                 280                 285             
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
    290                 295                 300                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 
Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
                325                 330                 335     
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
            340                 345                 350         
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
        355                 360                 365             
Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
    370                 375                 380                 
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
385                 390                 395                 400 
Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
                405                 410                 415     
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
            420                 425                 430         
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
        435                 440                 445             
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
465                 470                 475                 480 
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly 
                485                 490                 495     
Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu 
            500                 505                 510         
Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
        515                 520                 525             
Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His 
    530                 535                 540                 
Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
545                 550                 555                 560 
Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala 
                565                 570                 575     
Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
            580                 585                 590         
Lys Ala Ala 
        595 

<210> 102
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 102
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 103
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 103
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 104
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 104
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 105
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 105
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
145                 150                 155                 160 
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                165                 170                 175     
Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly 
            180                 185                 190         
His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        195                 200                 205             
Ala Lys Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val 
    210                 215                 220                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
225                 230                 235                 240 
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
                245                 250                 255     
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
            260                 265                 270         
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
    290                 295                 300                 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
305                 310                 315                 320 
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
                325                 330                 335     
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
            340                 345                 350         
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
        355                 360                 365             
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
    370                 375                 380                 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
385                 390                 395                 400 
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
                405                 410                 415     
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
            420                 425                 430         
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
        435                 440                 445             
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
465                 470                 475                 480 
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly 
                485                 490                 495     
Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu 
            500                 505                 510         
Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
        515                 520                 525             
Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His 
    530                 535                 540                 
Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
545                 550                 555                 560 
Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala 
                565                 570                 575     
Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
            580                 585                 590         
Lys Ala Ala 
        595 

<210> 106
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 106
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 107
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 107
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 108
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 108
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    530                 535                 540                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 109
<211> 571
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 109
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
                245                 250                 255     
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
305                 310                 315                 320 
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Arg Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Asp Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys 
385                 390                 395                 400 
Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu 
                405                 410                 415     
Ile Leu Gln Lys Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
            420                 425                 430         
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp 
        435                 440                 445             
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
    450                 455                 460                 
Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Lys 
465                 470                 475                 480 
Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu Glu 
                485                 490                 495     
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            500                 505                 510         
Lys Asp Gly Tyr Thr Pro Leu His Leu Ala Ala Arg Glu Gly His Leu 
        515                 520                 525             
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
    530                 535                 540                 
Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn 
545                 550                 555                 560 
Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
                565                 570     

<210> 110
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 110
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Phe Gly His Leu Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ile Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Lys Leu Arg His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
        275                 280                 285             
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Leu Asp Gln Ile Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Asn Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Trp Gly Gln Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Trp Lys Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Thr Asp Gly Leu Thr 
            420                 425                 430         
Pro Leu His Leu Ala Ala Ile Arg Gly His Leu Glu Ile Val Glu Val 
        435                 440                 445             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys 
    450                 455                 460                 
Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
465                 470                 475                 480 
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
                485                 490                 495     
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
            500                 505                 510         
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
        515                 520                 525             
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe 
    530                 535                 540                 
Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe 
                565                 570                 575     
Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu 
            580                 585                 590         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
        595                 600                 605             
Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu 
    610                 615                 620                 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 

<210> 111
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 111
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Phe Gly His Leu Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ile Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Lys Leu Arg His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
        275                 280                 285             
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Leu Asp Gln Ile Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Asn Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Trp 
    530                 535                 540                 
Gly Gln Thr Pro Leu His Leu Ala Ala Trp Lys Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Thr 
                565                 570                 575     
Asp Gly Leu Thr Pro Leu His Leu Ala Ala Ile Arg Gly His Leu Glu 
            580                 585                 590         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
        595                 600                 605             
Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu 
    610                 615                 620                 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 

<210> 112
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 112
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Lys Ser Gly Asn Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Arg Phe Gly His Leu Glu Ile Val Glu Phe Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Thr Gly Lys Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ile Trp Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Tyr Gly Arg Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Lys Leu Arg His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr 
            420                 425                 430         
Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Leu Asp Gln Ile Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Asn Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Trp 
    530                 535                 540                 
Gly Gln Thr Pro Leu His Leu Ala Ala Trp Lys Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Thr 
                565                 570                 575     
Asp Gly Leu Thr Pro Leu His Leu Ala Ala Ile Arg Gly His Leu Glu 
            580                 585                 590         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
        595                 600                 605             
Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu 
    610                 615                 620                 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 

<210> 113
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 113
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala Ile Trp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Lys Leu Arg 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Leu Asp Gln Ile Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Asn Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Trp Gly Gln Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Trp Lys Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Thr Asp Gly Leu Thr 
            420                 425                 430         
Pro Leu His Leu Ala Ala Ile Arg Gly His Leu Glu Ile Val Glu Val 
        435                 440                 445             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys 
    450                 455                 460                 
Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
465                 470                 475                 480 
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
                485                 490                 495     
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
            500                 505                 510         
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
        515                 520                 525             
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe 
    530                 535                 540                 
Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe 
                565                 570                 575     
Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu 
            580                 585                 590         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
        595                 600                 605             
Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu 
    610                 615                 620                 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 

<210> 114
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 114
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala Ile Trp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Lys Leu Arg 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Leu Asp Gln Ile Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Leu Trp Gly Gln Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Trp Lys Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Lys Asp Thr Asp Gly Leu Thr Pro Leu His Leu 
        275                 280                 285             
Ala Ala Ile Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
    290                 295                 300                 
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
305                 310                 315                 320 
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
                325                 330                 335     
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
            340                 345                 350         
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
        355                 360                 365             
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
            420                 425                 430         
Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val 
        435                 440                 445             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
    450                 455                 460                 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
465                 470                 475                 480 
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
                485                 490                 495     
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
            500                 505                 510         
Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
        515                 520                 525             
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe 
    530                 535                 540                 
Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe 
                565                 570                 575     
Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu 
            580                 585                 590         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
        595                 600                 605             
Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu 
    610                 615                 620                 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 

<210> 115
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 115
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Lys Ser Gly Asn Thr Pro Leu His Leu Ala Ala Arg Phe Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Phe Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Glu Thr Gly Lys Thr Pro Leu His Leu Ala Ala Ile Trp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Leu Tyr Gly Arg Thr Pro Leu His Leu Ala Ala Lys Leu Arg 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    130                 135                 140                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Leu Asp Gln Ile Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Asn Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Trp 
    530                 535                 540                 
Gly Gln Thr Pro Leu His Leu Ala Ala Trp Lys Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Thr 
                565                 570                 575     
Asp Gly Leu Thr Pro Leu His Leu Ala Ala Ile Arg Gly His Leu Glu 
            580                 585                 590         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
        595                 600                 605             
Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu 
    610                 615                 620                 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 

<210> 116
<211> 595
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 116
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
145                 150                 155                 160 
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                165                 170                 175     
Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly 
            180                 185                 190         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        195                 200                 205             
Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr 
    210                 215                 220                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
225                 230                 235                 240 
Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn 
                245                 250                 255     
Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
            260                 265                 270         
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
        275                 280                 285             
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
    290                 295                 300                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 
Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
                325                 330                 335     
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
            340                 345                 350         
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
        355                 360                 365             
Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
    370                 375                 380                 
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
385                 390                 395                 400 
Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
                405                 410                 415     
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
            420                 425                 430         
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
        435                 440                 445             
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
465                 470                 475                 480 
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly 
                485                 490                 495     
Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu 
            500                 505                 510         
Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
        515                 520                 525             
Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His 
    530                 535                 540                 
Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
545                 550                 555                 560 
Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala 
                565                 570                 575     
Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
            580                 585                 590         
Lys Ala Ala 
        595 

<210> 117
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 117
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 118
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 118
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 119
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 119
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    530                 535                 540                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 120
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 120
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu 
    50                  55                  60                  
Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly 
            100                 105                 110         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        115                 120                 125             
Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala 
    130                 135                 140                 
Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro 
145                 150                 155                 160 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
                165                 170                 175     
Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
            180                 185                 190         
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    530                 535                 540                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 121
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 121
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    530                 535                 540                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 122
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 122
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
                245                 250                 255     
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly 
            500                 505                 510         
Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr 
    530                 535                 540                 
Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 123
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 123
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala 
            340                 345                 350         
Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly 
            500                 505                 510         
Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr 
    530                 535                 540                 
Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 124
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 124
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val 
            180                 185                 190         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp 
    210                 215                 220                 
Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Pro Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala 
385                 390                 395                 400 
Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu 
                405                 410                 415     
Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
            420                 425                 430         
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys 
        435                 440                 445             
Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
    450                 455                 460                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp 
465                 470                 475                 480 
Thr Pro Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu 
                485                 490                 495     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly 
            500                 505                 510         
Asn Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala 
    530                 535                 540                 
Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 125
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 125
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser 
                245                 250                 255     
Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu 
        355                 360                 365             
His Leu Ala Asp Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro 
385                 390                 395                 400 
Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
                405                 410                 415     
Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
            420                 425                 430         
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys 
        435                 440                 445             
Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
    450                 455                 460                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp 
465                 470                 475                 480 
Thr Pro Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu 
                485                 490                 495     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly 
            500                 505                 510         
Asn Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala 
    530                 535                 540                 
Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 126
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 126
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val 
            180                 185                 190         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp 
    210                 215                 220                 
Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu 
        355                 360                 365             
His Leu Ala Asp Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro 
385                 390                 395                 400 
Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
                405                 410                 415     
Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
            420                 425                 430         
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys 
        435                 440                 445             
Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile 
    450                 455                 460                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp 
465                 470                 475                 480 
Thr Pro Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu 
                485                 490                 495     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly 
            500                 505                 510         
Asn Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala 
    530                 535                 540                 
Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 127
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 127
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Leu 
        35                  40                  45              
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly 
            100                 105                 110         
Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val 
            180                 185                 190         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp 
    210                 215                 220                 
Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly 
            500                 505                 510         
Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr 
    530                 535                 540                 
Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 128
<211> 637
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 128
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro 
        115                 120                 125             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    130                 135                 140                 
Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
145                 150                 155                 160 
Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp 
                165                 170                 175     
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
            180                 185                 190         
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
        195                 200                 205             
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
    210                 215                 220                 
Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly 
225                 230                 235                 240 
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
                245                 250                 255     
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Leu Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
    450                 455                 460                 
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Arg Ser 
465                 470                 475                 480 
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
                485                 490                 495     
Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            500                 505                 510         
Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His Glu Gly His Leu 
        515                 520                 525             
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    530                 535                 540                 
Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala Ala Asp Gly His 
545                 550                 555                 560 
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                565                 570                 575     
Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly 
            580                 585                 590         
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
        595                 600                 605             
Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn 
    610                 615                 620                 
Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Leu Asn 
625                 630                 635         

<210> 129
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 129
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly 
            500                 505                 510         
Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr 
    530                 535                 540                 
Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 130
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 130
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 131
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 131
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg Gly 
            500                 505                 510         
Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu Thr 
    530                 535                 540                 
Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 132
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 132
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg 
            180                 185                 190         
Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Asn Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    530                 535                 540                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 133
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 133
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
1               5                   10                  15      
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
            20                  25                  30          
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
        35                  40                  45              
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
    50                  55                  60                  
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
65                  70                  75                  80  
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
                85                  90                  95      
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
            100                 105                 110         
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
        115                 120                 125             
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
    130                 135                 140                 
Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val 
            180                 185                 190         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp 
    210                 215                 220                 
Ser Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
        275                 280                 285             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    290                 295                 300                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
305                 310                 315                 320 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                325                 330                 335     
Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            500                 505                 510         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    530                 535                 540                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                565                 570                 575     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 134
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 134
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 135
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 135
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 136
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 136
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 137
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 137
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 138
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 138
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 139
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 139
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 140
<211> 636
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 140
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly 
            420                 425                 430         
Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
    450                 455                 460                 
Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
465                 470                 475                 480 
Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr 
                485                 490                 495     
Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser 
            500                 505                 510         
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        515                 520                 525             
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
545                 550                 555                 560 
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
    610                 615                 620                 
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 635     

<210> 141
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 141
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 142
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 142
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Phe Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Lys Ile Val Glu Val Leu Leu Lys His Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Trp Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Met Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Met Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
His Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe 
        275                 280                 285             
Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 143
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 143
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 144
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 144
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 145
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 145
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
            500                 505                 510         
Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 146
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 146
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
            500                 505                 510         
Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 147
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 147
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn 
            100                 105                 110         
Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 148
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 148
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn 
            100                 105                 110         
Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 149
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 149
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala 
                325                 330                 335     
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
            340                 345                 350         
Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu 
        355                 360                 365             
Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala 
    370                 375                 380                 
Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His 
385                 390                 395                 400 
Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
                405                 410                 415     
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
            420                 425                 430         
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
        435                 440                 445             
Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 
Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu 
465                 470                 475                 480 
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
                485                 490                 495     
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
            500                 505                 510         
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
        515                 520                 525             
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
    530                 535                 540                 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
545                 550                 555                 560 
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
                565                 570                 575     
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
            580                 585                 590         
Leu Gln Lys Ala Ala 
        595         

<210> 150
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 150
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 151
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 151
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu 
            500                 505                 510         
Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
    530                 535                 540                 
Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 152
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 152
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
    290                 295                 300                 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
305                 310                 315                 320 
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
                325                 330                 335     
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            340                 345                 350         
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
        355                 360                 365             
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
    370                 375                 380                 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
385                 390                 395                 400 
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
                405                 410                 415     
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
            420                 425                 430         
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
        435                 440                 445             
Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 
Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu 
465                 470                 475                 480 
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
                485                 490                 495     
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
            500                 505                 510         
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
        515                 520                 525             
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
    530                 535                 540                 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
545                 550                 555                 560 
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
                565                 570                 575     
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
            580                 585                 590         
Leu Gln Lys Ala Ala 
        595         

<210> 153
<211> 582
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 153
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
    130                 135                 140                 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
145                 150                 155                 160 
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
                165                 170                 175     
Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu Glu 
            180                 185                 190         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp 
        195                 200                 205             
Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu 
    210                 215                 220                 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
225                 230                 235                 240 
Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His 
                245                 250                 255     
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            260                 265                 270         
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
        275                 280                 285             
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
    290                 295                 300                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp 
305                 310                 315                 320 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                325                 330                 335     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            340                 345                 350         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        355                 360                 365             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    370                 375                 380                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
385                 390                 395                 400 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                405                 410                 415     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            420                 425                 430         
Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro 
        435                 440                 445             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    450                 455                 460                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
465                 470                 475                 480 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
                485                 490                 495     
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
            500                 505                 510         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
        515                 520                 525             
Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val 
    530                 535                 540                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
545                 550                 555                 560 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
                565                 570                 575     
Val Leu Gln Lys Ala Ala 
            580         

<210> 154
<211> 561
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 154
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu 
    130                 135                 140                 
Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala 
145                 150                 155                 160 
Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His 
                165                 170                 175     
Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            180                 185                 190         
Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu 
        195                 200                 205             
His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu 
    210                 215                 220                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro 
225                 230                 235                 240 
Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu 
                245                 250                 255     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            260                 265                 270         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        275                 280                 285             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Gly Ser Asp 
    290                 295                 300                 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
305                 310                 315                 320 
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
                325                 330                 335     
Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu 
            340                 345                 350         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
        355                 360                 365             
Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu 
    370                 375                 380                 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
385                 390                 395                 400 
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
                405                 410                 415     
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
            420                 425                 430         
Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg 
        435                 440                 445             
Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp 
    450                 455                 460                 
Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala 
465                 470                 475                 480 
Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
                485                 490                 495     
Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala 
            500                 505                 510         
Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        515                 520                 525             
Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile 
    530                 535                 540                 
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
545                 550                 555                 560 
Ala 
    

<210> 155
<211> 582
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 155
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp 
    130                 135                 140                 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
145                 150                 155                 160 
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
                165                 170                 175     
Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu Glu 
            180                 185                 190         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp 
        195                 200                 205             
Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu 
    210                 215                 220                 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
225                 230                 235                 240 
Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His 
                245                 250                 255     
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            260                 265                 270         
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
        275                 280                 285             
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp 
305                 310                 315                 320 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                325                 330                 335     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            340                 345                 350         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        355                 360                 365             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    370                 375                 380                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile 
385                 390                 395                 400 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                405                 410                 415     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            420                 425                 430         
Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu 
    450                 455                 460                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
465                 470                 475                 480 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
                485                 490                 495     
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
            500                 505                 510         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
        515                 520                 525             
Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val 
    530                 535                 540                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
545                 550                 555                 560 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
                565                 570                 575     
Val Leu Gln Lys Ala Ala 
            580         

<210> 156
<211> 567
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 156
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu 
    130                 135                 140                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
145                 150                 155                 160 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro 
                165                 170                 175     
Leu His Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu 
            180                 185                 190         
Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr 
        195                 200                 205             
Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val 
    210                 215                 220                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn 
225                 230                 235                 240 
Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu 
                245                 250                 255     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            260                 265                 270         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        275                 280                 285             
Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
305                 310                 315                 320 
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
                325                 330                 335     
Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp 
            340                 345                 350         
Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        355                 360                 365             
Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala 
    370                 375                 380                 
Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
385                 390                 395                 400 
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
                405                 410                 415     
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
            420                 425                 430         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys 
        435                 440                 445             
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
    450                 455                 460                 
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
465                 470                 475                 480 
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
                485                 490                 495     
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
            500                 505                 510         
Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu 
        515                 520                 525             
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
    530                 535                 540                 
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
545                 550                 555                 560 
Glu Val Leu Gln Lys Ala Ala 
                565         

<210> 157
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 157
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 158
<211> 599
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 158
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys 
465                 470                 475                 480 
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
                485                 490                 495     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
            500                 505                 510         
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
        515                 520                 525             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
    530                 535                 540                 
Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu 
545                 550                 555                 560 
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
                565                 570                 575     
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
            580                 585                 590         
Glu Val Leu Gln Lys Ala Ala 
        595                 

<210> 159
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 159
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala 
                325                 330                 335     
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
            340                 345                 350         
Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu 
        355                 360                 365             
Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala 
    370                 375                 380                 
Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His 
385                 390                 395                 400 
Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
                405                 410                 415     
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
            420                 425                 430         
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
        435                 440                 445             
Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 
Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu 
465                 470                 475                 480 
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
                485                 490                 495     
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
            500                 505                 510         
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
        515                 520                 525             
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
    530                 535                 540                 
Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu 
545                 550                 555                 560 
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
                565                 570                 575     
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
            580                 585                 590         
Leu Gln Lys Ala Ala 
        595         

<210> 160
<211> 582
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 160
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp 
    130                 135                 140                 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
145                 150                 155                 160 
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
                165                 170                 175     
Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp Ile Gly His Leu Glu 
            180                 185                 190         
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp 
        195                 200                 205             
Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu 
    210                 215                 220                 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
225                 230                 235                 240 
Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His 
                245                 250                 255     
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            260                 265                 270         
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
        275                 280                 285             
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp 
305                 310                 315                 320 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                325                 330                 335     
Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly 
            340                 345                 350         
Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val 
        355                 360                 365             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln 
    370                 375                 380                 
Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile 
385                 390                 395                 400 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                405                 410                 415     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp 
            420                 425                 430         
Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly 
        435                 440                 445             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu 
    450                 455                 460                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu 
465                 470                 475                 480 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
                485                 490                 495     
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
            500                 505                 510         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
        515                 520                 525             
Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val 
    530                 535                 540                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
545                 550                 555                 560 
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
                565                 570                 575     
Val Leu Gln Lys Ala Ala 
            580         

<210> 161
<211> 567
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 161
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu 
    130                 135                 140                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
145                 150                 155                 160 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro 
                165                 170                 175     
Leu His Leu Ala Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu 
            180                 185                 190         
Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr 
        195                 200                 205             
Pro Leu His Leu Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val 
    210                 215                 220                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn 
225                 230                 235                 240 
Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu 
                245                 250                 255     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            260                 265                 270         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        275                 280                 285             
Glu Val Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 
Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly 
305                 310                 315                 320 
Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
                325                 330                 335     
Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp 
            340                 345                 350         
Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        355                 360                 365             
Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala 
    370                 375                 380                 
Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
385                 390                 395                 400 
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
                405                 410                 415     
Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
            420                 425                 430         
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys 
        435                 440                 445             
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
    450                 455                 460                 
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
465                 470                 475                 480 
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
                485                 490                 495     
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
            500                 505                 510         
Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu 
        515                 520                 525             
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
    530                 535                 540                 
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
545                 550                 555                 560 
Glu Val Leu Gln Lys Ala Ala 
                565         

<210> 162
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 162
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
305                 310                 315                 320 
Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    450                 455                 460                 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly 
465                 470                 475                 480 
Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg 
                485                 490                 495     
Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser 
            500                 505                 510         
His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val 
        515                 520                 525             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala 
    530                 535                 540                 
Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile 
545                 550                 555                 560 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile 
                565                 570                 575     
Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp 
            580                 585                 590         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600     

<210> 163
<211> 599
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 163
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu 
                325                 330                 335     
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys 
            340                 345                 350         
Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu 
        355                 360                 365             
His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu 
    370                 375                 380                 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr Pro 
385                 390                 395                 400 
Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu 
                405                 410                 415     
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr 
            420                 425                 430         
Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
        435                 440                 445             
Leu Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    450                 455                 460                 
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys 
465                 470                 475                 480 
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
                485                 490                 495     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
            500                 505                 510         
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
        515                 520                 525             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
    530                 535                 540                 
Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu 
545                 550                 555                 560 
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
                565                 570                 575     
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
            580                 585                 590         
Glu Val Leu Gln Lys Ala Ala 
        595                 

<210> 164
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 164
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 165
<211> 636
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 165
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly 
            420                 425                 430         
Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
    450                 455                 460                 
Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
465                 470                 475                 480 
Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr 
                485                 490                 495     
Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser 
            500                 505                 510         
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        515                 520                 525             
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
545                 550                 555                 560 
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
    610                 615                 620                 
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
625                 630                 635     

<210> 166
<211> 636
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 166
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala His Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His 
                245                 250                 255     
Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe 
        275                 280                 285             
Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly 
            420                 425                 430         
Asn Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser 
    450                 455                 460                 
Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile 
465                 470                 475                 480 
Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr 
                485                 490                 495     
Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser 
            500                 505                 510         
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        515                 520                 525             
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
545                 550                 555                 560 
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
    610                 615                 620                 
His Glu Asp Ile Ala Glu Val Leu Gln Lys Leu Asn 
625                 630                 635     

<210> 167
<211> 630
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 167
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala Ala Asp 
            180                 185                 190         
Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His Leu Ala 
                245                 250                 255     
Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
        275                 280                 285             
Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala 
                325                 330                 335     
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
            340                 345                 350         
Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu 
        355                 360                 365             
Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
    370                 375                 380                 
Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His 
385                 390                 395                 400 
Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
                405                 410                 415     
Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu 
            420                 425                 430         
His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu 
        435                 440                 445             
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala 
    450                 455                 460                 
Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu 
465                 470                 475                 480 
Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu 
            500                 505                 510         
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
        515                 520                 525             
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
    530                 535                 540                 
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
545                 550                 555                 560 
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
                565                 570                 575     
Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val 
            580                 585                 590         
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
        595                 600                 605             
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
    610                 615                 620                 
Val Leu Gln Lys Leu Asn 
625                 630 

<210> 168
<211> 630
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 168
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala Ala His 
            180                 185                 190         
Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His Leu Ser 
                245                 250                 255     
Ala Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
            260                 265                 270         
Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe Asp Ile 
        275                 280                 285             
Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys Ala 
    290                 295                 300                 
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 
Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala 
                325                 330                 335     
Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
            340                 345                 350         
Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu 
        355                 360                 365             
Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala 
    370                 375                 380                 
Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His 
385                 390                 395                 400 
Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
                405                 410                 415     
Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu 
            420                 425                 430         
His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu 
        435                 440                 445             
Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro 
    450                 455                 460                 
Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu 
465                 470                 475                 480 
Gln Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     
Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu 
            500                 505                 510         
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met 
        515                 520                 525             
Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro 
    530                 535                 540                 
Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu 
545                 550                 555                 560 
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr 
                565                 570                 575     
Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val 
            580                 585                 590         
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys 
        595                 600                 605             
Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
    610                 615                 620                 
Val Leu Gln Lys Leu Asn 
625                 630 

<210> 169
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 169
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 170
<211> 597
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 170
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala 
145                 150                 155                 160 
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val 
                165                 170                 175     
Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro 
            180                 185                 190         
Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        195                 200                 205             
Val Asn Ala Lys Asp Tyr Gln Gly Trp Thr Pro Leu His Leu Ala Ala 
    210                 215                 220                 
Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
225                 230                 235                 240 
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
                245                 250                 255     
Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            260                 265                 270         
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        275                 280                 285             
Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
    290                 295                 300                 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
305                 310                 315                 320 
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
                325                 330                 335     
Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
            340                 345                 350         
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
        355                 360                 365             
Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
    370                 375                 380                 
Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His 
385                 390                 395                 400 
Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
                405                 410                 415     
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
            420                 425                 430         
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
        435                 440                 445             
Lys Ala Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    450                 455                 460                 
Gly Ser Gly Gly Gly Gly Ser Gly Ser Asp Leu Gly Lys Lys Leu Leu 
465                 470                 475                 480 
Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys 
                485                 490                 495     
Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu 
            500                 505                 510         
His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu 
        515                 520                 525             
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro 
    530                 535                 540                 
Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu Val Leu 
545                 550                 555                 560 
Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr 
                565                 570                 575     
Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val 
            580                 585                 590         
Leu Gln Lys Ala Ala 
        595         

<210> 171
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 171
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 172
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 172
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Tyr Gln Gly Trp Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ala Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr 
            500                 505                 510         
Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 173
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 173
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
            500                 505                 510         
Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 174
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 174
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Arg Asn Gly His Leu Lys Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Asn Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
            500                 505                 510         
Thr Gly Trp Thr Pro Leu His Leu Ala Ala Pro Trp Gly His Pro Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Phe Gln Gly Trp Thr Pro Leu His Leu Ala Ala Ala Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 175
<211> 636
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 175
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ala Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Ala Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Lys Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly 
            420                 425                 430         
Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
    450                 455                 460                 
Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
465                 470                 475                 480 
Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr 
                485                 490                 495     
Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser 
            500                 505                 510         
Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        515                 520                 525             
Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly His Leu 
545                 550                 555                 560 
Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Asp Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp Ala Gly 
    610                 615                 620                 
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 635     

<210> 176
<211> 570
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 176
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Met Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala His Asp Thr Trp Gly Leu Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Phe His Gly His Gln Glu Ile Val Glu Val Leu Leu Lys His Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Gln Asp Phe Tyr Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Leu Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Gln Phe Gly Lys Thr Ala Phe Asp 
                245                 250                 255     
Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Thr Gly Trp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Pro Trp Gly His Pro Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Gln Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ala Ala Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu Arg 
465                 470                 475                 480 
Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn Glu 
            500                 505                 510         
Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
                565                 570 

<210> 177
<211> 636
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 177
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Arg Tyr Gly Asp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Asp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Glu Asp Tyr Phe Gly Asn Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ser Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asp Tyr Gly Asn Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Asn Thr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly 
            420                 425                 430         
Trp Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe 
    450                 455                 460                 
Gly Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu 
465                 470                 475                 480 
Ala Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr 
                485                 490                 495     
Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser 
            500                 505                 510         
Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp 
        515                 520                 525             
Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly 
    610                 615                 620                 
His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
625                 630                 635     

<210> 178
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 178
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Met Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala 
                165                 170                 175     
Asp Val Asn Ala His Asp Thr Trp Gly Leu Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Phe His Gly His Gln Glu Ile Val Glu Val Leu Leu Lys His Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Gln Asp Phe Tyr Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Leu Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Tyr 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Gln Phe Gly Lys Thr Ala Phe Asp 
                245                 250                 255     
Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu 
    290                 295                 300                 
Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala His Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly 
            420                 425                 430         
Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala 
        435                 440                 445             
Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu 
            500                 505                 510         
Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
    530                 535                 540                 
Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 179
<211> 603
<212> PRT
<213> Artificial Sequence

<220> 
<223> Protein comprising four designed ankyrin repeat domains

<400> 179
Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asn Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Asp Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Leu Gly Trp Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala His Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Ser Gly Tyr Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Ala Asp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Asn Thr Gly Trp Thr Pro Leu His 
                245                 250                 255     
Leu Ser Ala Asp Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Phe Gly Lys Thr Ala Phe 
        275                 280                 285             
Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala Glu Ile Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Met Lys 
                325                 330                 335     
Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Met Ala Asn Gly Ala Asp Val Asn Ala His Asp Thr Trp Gly Leu Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Phe His Gly His Gln Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys His Gly Ala Asp Val Asn Ala Gln Asp Phe Tyr Gly Lys 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Leu Arg Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Tyr Gly Ala Asp Val Asn Ala Gln Asp Gln Phe Gly 
            420                 425                 430         
Lys Thr Ala Phe Asp Ile Ser Ile Asp Asn Gly Asn Glu Asp Leu Ala 
        435                 440                 445             
Glu Ile Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Asp Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Met Ala Asn Gly Ala Asp Val Asn Ala Lys Asp Glu 
            500                 505                 510         
Arg Gly Thr Thr Pro Leu His Leu Ala Ala Val Tyr Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asn 
    530                 535                 540                 
Glu Thr Gly Tyr Thr Pro Leu His Leu Ala Asp Ser Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys His Ser Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Asp Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        595                 600             

<210> 180
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ankyrin repeat module of designed ankyrin repeat domains with
      binding specificity for serum albumin.

<400> 180
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
1               5                   10                  15      
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

<210> 181
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> Ankyrin repeat module of designed ankyrin repeat domains with
      binding specificity for serum albumin.

<220> 
<221> VARIANT
<222> 1
<223> Xaa represents an amino acid residue selected from the group
      consisting of D, K and A

<220> 
<221> VARIANT
<222> 1..33
<223> Optionally up to 5, 4, 3, 2, 1, 0 amino acids in other than the
      positions denoted with Xaa can be exchanged by any amino acid

<220> 
<221> VARIANT
<222> 5
<223> Xaa represents an amino acid residue selected from the group
      consisting of D, G and S
<220> 
<221> VARIANT
<222> 15
<223> Xaa represents an amino acid residue selected from the group
      consisting of E, N, D, H, S, A, Q, T and G

<220> 
<221> VARIANT
<222> 16
<223> Xaa represents an amino acid residue selected from the group
      consisting of G and D

<220> 
<221> VARIANT
<222> 19
<223> Xaa represents an amino acid residue selected from the group
      consisting of E, K and G

<220> 
<221> VARIANT
<222> 27
<223> Xaa represents an amino acid residue selected from the group
      consisting of H, Y, A and N

<400> 181
Xaa Asp Tyr Phe Xaa His Thr Pro Leu His Leu Ala Ala Arg Xaa Xaa 
1               5                   10                  15      
His Leu Xaa Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn 
            20                  25                  30          
Ala 
    

