                         SEQUENCE LISTING

<110>  University of Copenhagen
       Evolva SA
 
<120>  Biosynthesis of acetylated 13R-MO and related compounds

<130>  16-103-WO

<150>  PA 201570220
<151>  2015-04-15

<150>  PA 201570330
<151>  2015-05-29

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1284
<212>  DNA
<213>  Coleus forskohlii

<400>  1
atgaaggtgg aaagatttag caggaaactc ataaaaccgc acaccccaac ccccgaaaat       60

ctgaagaagt ataagctttc tcttttagac aaatgcttgg ggcacgataa ttttgctatt      120

gttctgtttt acgaatcgaa accaagaaac aagagtgagt tggaagaatc actggaaaaa      180

gtcctggtgg atttctaccc tcttgctgga agacacacca tgaatgatca catagttgat      240

tgcagtgatg tgggcgccgt gtttgtcgaa gcagaagctc tagacgtcga gctgacgatg      300

gatgagctcg ttaagaacat ggaggcccag actatccatc atctccttcc caatcaatat      360

ttctcagctg atgctccaaa tccactcttg tcaatccagg tgacacattt cccatctggt      420

ggcctagcaa ttggcatcgc cgtttctcac gctgtcttcg atggtttttc gctgggggtg      480

ttcgtcgccg cctggtcgaa ggccaccatg aacccagatc ggaagatcaa aatcacaccg      540

tctttcgatc ttccctcgtt gcttccttac aaggatgaca attttggatt aactgccgcc      600

gaaattgtca gccagagtga agatattgtt gttaagaggt ttattttcgg gaaggaggca      660

ataacgaggt tgagatcaaa gctaagccca aatcgcaatg ggaaaaagat ctctcgtgtt      720

cgagtggtgt gtgccgttat agtgaaagcc ttgatgggcc tggaacgcgc caaacatggc      780

aaaacaagag atttcttgat cactcaatcg attaacatgc gcgagagaac aaaagcacct      840

ctacagaagc atgcttgtgg gaatctggca gtcttgtcgt gcacgcgacg tgtagaagcc      900

gaggagatga tggagctgca gaacttggtt aatctgatcg gagattctac agagaaggac      960

atagctgatt ttgctgaatt gctatctcct gatcaagttg ggcgtgatat catcatcaag     1020

atgatgaagt ctttcatgca attcttggat aatgacattt attctgtatg cttcactgat     1080

tggagtaagt ttgaatttta cgaagctgat tttgggttcg ggaagcctgt ttggatggcc     1140

gctggaccgc aacgcccaat cattagcacc gctattctca tgagcgacag agagggtgat     1200

ggaattgagg catggctgca tctcaacaaa aatgacatgc ttatcttcga gcaagatgaa     1260

gaaatcaaat tatttactac ctaa                                            1284


<210>  2
<211>  1284
<212>  DNA
<213>  Coleus forskohlii

<400>  2
atgaaggtgg aaagatttag caggaaactc ataaaaccgc acaccccaac ccccgaaaat       60

ctcaagaatt ataagctttc tcttttagat aaatgcttgg tgcaggataa ttttgctgtt      120

gtgctgtttt acgaatcgaa accaagaaac aagagtgagt tggaagaatc actagaaaaa      180

gtccttgtcg atttctaccc tcttgctgga agatacacca tgaatgatca catagttgat      240

tgcagtgatg agggcgccgt gtttgtcgaa gctgaagctc tggatgctga gctgacgatg      300

gatcagctcg tcaagaatat ggaggcccag actatccatc atctccttcc ggatcaatat      360

ttcccagctg atgctccaat tccactcctc tcaatccagg tcacacattt cccatttggg      420

ggcctggcaa ttgccatcgt cgtttctcac gctgtattcg aaggtttttc actcggggtg      480

ttcgtcgccg cctggtcgaa ggccaccatt aatccagatg tgaagatcga aatcaccccg      540

tctttcgatc ttccctcatt gcttccatac aaggatgacg atttcggatt aactgactgt      600

gaaattatta acctgtgtga ggatattgtt gttaagaggt ttatgtttgg gaaggaggct      660

ataacgaggt tgagatcaag actaagccca aatcacaatg ggaaaacgat ctctcgtgtt      720

cgagtggtgt gtgccgttat agtgaaagcc ttgatgggcc tggaacgcgc caaacatggc      780

aaaacaagag atttcttgat cactcaatcg attaacatgc gcgagagaac aaaagcacct      840

ctacagaagc atgcttgtgg gaatctggca gtcttgtcgt gcacgcgacg tgtagaagcc      900

gaggagatga tggagctgca gaacttggtt aatctgatcg gagaatctac tgagaaggac      960

atagctcatt attctgaatt gctgtctcat aatcaatttg ggcgtgatat catcgtcaac     1020

gtgatgaaat ctctcatgca attcttggat cctgacattt attctgtatg cttcactgat     1080

tggagtaagt ttagattcta cgaagctgat tttgggttcg ggaagcctgt ttggacggcc     1140

gttggaccgc aacgcccaat cattaccacc gctattctca tgaacaacag agagggtgat     1200

ggaattgagg catggctgca tctcaacaaa aatgacatgc ttatcttcga gcaagatgaa     1260

gaaatcaaat tatttactac ctaa                                            1284


<210>  3
<211>  1278
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric sequence comprising sequences from two ACTs from Coleus 
       forskohlii

<400>  3
atgaaggtgg aaagatttag caggaaattc ataaaaccac acaccccgac ccccgaaaat       60

ctgaagaagt ataagctttc tcttttagac aaatgcttgg ggcacgataa ttttgctatt      120

gttctgtttt acgaatcgaa accaagaaac aagagtgagt tggaagaatc actggaaaaa      180

gtcctggtgg atttctaccc tcttgctgga agacacacca tgaatgatca catagttgat      240

tgcagtgatg tgggcgccgt gtttgtcgaa gcagaagctc tagacgtcga gctgacgatg      300

gatgagctcg ttaagaacat ggaggcccag actatccatc atctccttcc caatcaatat      360

ttctcagctg atgctccaaa tccactcttg tcaatccagg tgacacattt cccatctggt      420

ggcctagcaa ttggcatcgc cgtttctcac gctgtcttcg atggtttttc gctgggggtg      480

ttcgtcgccg cctggtcgaa ggccaccatg aacccagatc ggaagatcaa aatcacaccg      540

tctttcgatc ttccctcgtt gcttccttac aaggatgaca attttggatt aactgccgcc      600

gaaattgtca gccagagtga agatattgtt gttaagaggt ttattttcgg gaaggaggca      660

ataacgaggt tgagatcaaa gctaagccca aatcgcaatg ggaaaaagat ctctcgtgtt      720

cgagtggtgt gtgccgttat agtgaaagcc ttgatgggcc tggaacgcgc caaaacaaga      780

gatttcatga tctgtcaagg gatcaacatg cgtgagagaa caaaggcacc tctacagaag      840

catgcttgtg ggaatctggc ggtctcgtct tacacgcgac gtgtagccgc agcagaagcc      900

gaggagctgc agagtttggt aaatctaata ggtgattcta ttgagaagag catagctgat      960

tatgctgata ttctttcttc tgatcaagat gggcgtcata tcatcagcac gatgatgaaa     1020

tctttcatgc aattcgcggc tcctgacata aaagctatat ccttcactga ttggagtaag     1080

tttggattct accaagttga ttttgggttc gggaagcctg tttggacggg tgttcggccc     1140

gaacgcccaa tctttagcgc cgctattctc atgagcaaca gagagggtga tggaattgag     1200

gcatggcttc atcttgacaa aaatgacatg cttatcttcg agcaagatga agaaatcaaa     1260

ttattaatta ctacctaa                                                   1278


<210>  4
<211>  1281
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric sequence comprising sequences from Coleus forskohlii

<400>  4
atgaaggtgg aaagatttag caggaaattc ataaaaccac acaccccgac ccccgaaaat       60

ctgaagaagt ataagctttc tcttttagac aaatgcttgg ggcacgataa ttttgctatt      120

gttctgtttt acgaatcgaa accaagaaac aagagtgagt tggaagaatc actagaaaaa      180

gtccttgtcg atttctaccc tcttgctgga agatacacca tgaatgatca catagttgat      240

tgcagtgatg agggcgccgt gtttgtcgaa gccgaagctc caaacgtcga gctgacggtg      300

gatcaactcg tcaagaacat ggaggcccag actatccatg atttccttcc cgatcaatat      360

ttcccagctg atgctccaaa tccactcctc tcgatccagg tcacgcattt cccatgtggt      420

ggcttggcga ttggcatcgt tgtttctcac gctgtcttcg atggtttttc gctgggggtg      480

ttccttgccg cctggtcgaa ggccaccatg aacccagaga ggaagatcga aatcaccccg      540

tctttcgatc ttccttcgtt gcttccatac aaggatgaaa gtttcggatt aaatttcagc      600

gaaattgtca aggctgaaaa tattgttgtg aagaggctta atttcgggaa ggaggctata      660

acgaggttga gatcaagact aagcccaaat cacaatggga aaacgatctc tcgtgttcga      720

gttgtgtgtg cccttatagt gaaagccttg atgggcctgg aactcgccaa gcatggcaaa      780

acaagagatt tcatgatctc tcaagggatt aacatgcgcg agagaacaaa agcacctcta      840

cacaagcatg cttgtgggaa tctagcaatc ttgtcgtgca cgcgacgtgt agaagccgag      900

gagatgatgg acctgcaaaa cttggttaat ctgatcggag aatctactga gaaggacata      960

gctcattatt ctgaattgct gtctcataat caatttgggc gtgatatcat cgtcaacgtg     1020

atgaaatctc tcatgcaatt cttggatcct gacatttatt ctgtatgctt cactgattgg     1080

agtaagttta gattctacga agctgatttt gggttcggga agcctgtttg gacggccgtt     1140

ggaccgcaac gcccaatcat taccaccgct attctcatga acaacagaga gggtgatgga     1200

attgaggcat ggctgcatct caacaaaaat gacatgctta tcttcgagca agatgaagaa     1260

atcaaattat ttactaccta a                                               1281


<210>  5
<211>  1302
<212>  DNA
<213>  Coleus forskohlii

<400>  5
atgaaggtgg aaagatttag caggaaatta ataaaaccag tcaccccaac tccacaaaac       60

ctcaagaact tcaacctttc gattttagat aaatgtcttc cgccgattaa atttggtgtt      120

gttttgtttt atgaatctaa accaggaaat aagagcgagt tggaagaatc actaaaagaa      180

gttctggtcg acttctaccc tcttgctgga agacacacca tcaatgatcc cgtggttgat      240

tgcagtgatc agggcgccgt gttcgtcgaa gccgaagctc tagacaccga gctgaccatg      300

gatcagctgg tgttgaataa gatggagatc cagaaagtcg atcaattcct tcccgatgaa      360

tgcatccaag ctgatgctcc gaatccactc ctgtggatcc aggtgacaca tttcccatcg      420

ggtgggctgg cgatcggcgt tgcggtttct cactctgtct tcgattcctt ctcgctgggg      480

gtgttcatcg ccgcctggtc caaggccaca atgaatccag gtaggatgat cgaaatcacc      540

ccgtctttcg atgttccctc gttgcttcca tgcaaggatc acgatttcga gatagctctc      600

aatgaaatta cggatcaggg tgaaagcttc gttgttaaga ggctcgtgtt cggtaaggag      660

gctataacga ggttgagatc aaaactaagc ctaaatcaag atggtaaaac gatctctcgt      720

gttcgtgttg tgggtgccgt tctagtgaaa gccctgatcg gcctggaatg tggcaaacac      780

ggcagaagaa aagatctcgt gatctctctg ccggttaaca tgcgtgagag aacaaacaca      840

cctctacaga atccaaagca tgcttgcggg aatctggcgg tcatttcgct cacgcgatgc      900

gtagctgcag cagaagctga ggagatgggg ctgcaggagt tggtaaatct acttggagat      960

gcgattggaa aagcgatagc tgatcatgct gaaatgttgt ctcctaatca agaagggtgt     1020

gacatcatta ttaatgattt caagaacttt ttaacattat tcgggactcc taacacaaat     1080

attattactc ttactgattg gagtaagttt ggattctacg aagctgattt tgggtttggg     1140

aagcctgttt ggaccagcag cggacagcaa tccctgagcg ttaccaccat tgtgctcatg     1200

aacaacaaag agggcgatgg aatcgaggca tggctgcatc tcaacaaaaa tgacatgctt     1260

ttcttcgagc aagatgaaga aatcaaatta tttactacct aa                        1302


<210>  6
<211>  427
<212>  PRT
<213>  Coleus forskohlii

<400>  6

Met Lys Val Glu Arg Phe Ser Arg Lys Leu Ile Lys Pro His Thr Pro 
1               5                   10                  15      


Thr Pro Glu Asn Leu Lys Lys Tyr Lys Leu Ser Leu Leu Asp Lys Cys 
            20                  25                  30          


Leu Gly His Asp Asn Phe Ala Ile Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Arg Asn Lys Ser Glu Leu Glu Glu Ser Leu Glu Lys Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg His Thr Met Asn Asp His Ile Val Asp 
65                  70                  75                  80  


Cys Ser Asp Val Gly Ala Val Phe Val Glu Ala Glu Ala Leu Asp Val 
                85                  90                  95      


Glu Leu Thr Met Asp Glu Leu Val Lys Asn Met Glu Ala Gln Thr Ile 
            100                 105                 110         


His His Leu Leu Pro Asn Gln Tyr Phe Ser Ala Asp Ala Pro Asn Pro 
        115                 120                 125             


Leu Leu Ser Ile Gln Val Thr His Phe Pro Ser Gly Gly Leu Ala Ile 
    130                 135                 140                 


Gly Ile Ala Val Ser His Ala Val Phe Asp Gly Phe Ser Leu Gly Val 
145                 150                 155                 160 


Phe Val Ala Ala Trp Ser Lys Ala Thr Met Asn Pro Asp Arg Lys Ile 
                165                 170                 175     


Lys Ile Thr Pro Ser Phe Asp Leu Pro Ser Leu Leu Pro Tyr Lys Asp 
            180                 185                 190         


Asp Asn Phe Gly Leu Thr Ala Ala Glu Ile Val Ser Gln Ser Glu Asp 
        195                 200                 205             


Ile Val Val Lys Arg Phe Ile Phe Gly Lys Glu Ala Ile Thr Arg Leu 
    210                 215                 220                 


Arg Ser Lys Leu Ser Pro Asn Arg Asn Gly Lys Lys Ile Ser Arg Val 
225                 230                 235                 240 


Arg Val Val Cys Ala Val Ile Val Lys Ala Leu Met Gly Leu Glu Arg 
                245                 250                 255     


Ala Lys His Gly Lys Thr Arg Asp Phe Leu Ile Thr Gln Ser Ile Asn 
            260                 265                 270         


Met Arg Glu Arg Thr Lys Ala Pro Leu Gln Lys His Ala Cys Gly Asn 
        275                 280                 285             


Leu Ala Val Leu Ser Cys Thr Arg Arg Val Glu Ala Glu Glu Met Met 
    290                 295                 300                 


Glu Leu Gln Asn Leu Val Asn Leu Ile Gly Asp Ser Thr Glu Lys Asp 
305                 310                 315                 320 


Ile Ala Asp Phe Ala Glu Leu Leu Ser Pro Asp Gln Val Gly Arg Asp 
                325                 330                 335     


Ile Ile Ile Lys Met Met Lys Ser Phe Met Gln Phe Leu Asp Asn Asp 
            340                 345                 350         


Ile Tyr Ser Val Cys Phe Thr Asp Trp Ser Lys Phe Glu Phe Tyr Glu 
        355                 360                 365             


Ala Asp Phe Gly Phe Gly Lys Pro Val Trp Met Ala Ala Gly Pro Gln 
    370                 375                 380                 


Arg Pro Ile Ile Ser Thr Ala Ile Leu Met Ser Asp Arg Glu Gly Asp 
385                 390                 395                 400 


Gly Ile Glu Ala Trp Leu His Leu Asn Lys Asn Asp Met Leu Ile Phe 
                405                 410                 415     


Glu Gln Asp Glu Glu Ile Lys Leu Phe Thr Thr 
            420                 425         


<210>  7
<211>  427
<212>  PRT
<213>  Coleus forskohlii

<400>  7

Met Lys Val Glu Arg Phe Ser Arg Lys Leu Ile Lys Pro His Thr Pro 
1               5                   10                  15      


Thr Pro Glu Asn Leu Lys Asn Tyr Lys Leu Ser Leu Leu Asp Lys Cys 
            20                  25                  30          


Leu Val Gln Asp Asn Phe Ala Val Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Arg Asn Lys Ser Glu Leu Glu Glu Ser Leu Glu Lys Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg Tyr Thr Met Asn Asp His Ile Val Asp 
65                  70                  75                  80  


Cys Ser Asp Glu Gly Ala Val Phe Val Glu Ala Glu Ala Leu Asp Ala 
                85                  90                  95      


Glu Leu Thr Met Asp Gln Leu Val Lys Asn Met Glu Ala Gln Thr Ile 
            100                 105                 110         


His His Leu Leu Pro Asp Gln Tyr Phe Pro Ala Asp Ala Pro Ile Pro 
        115                 120                 125             


Leu Leu Ser Ile Gln Val Thr His Phe Pro Phe Gly Gly Leu Ala Ile 
    130                 135                 140                 


Ala Ile Val Val Ser His Ala Val Phe Glu Gly Phe Ser Leu Gly Val 
145                 150                 155                 160 


Phe Val Ala Ala Trp Ser Lys Ala Thr Ile Asn Pro Asp Val Lys Ile 
                165                 170                 175     


Glu Ile Thr Pro Ser Phe Asp Leu Pro Ser Leu Leu Pro Tyr Lys Asp 
            180                 185                 190         


Asp Asp Phe Gly Leu Thr Asp Cys Glu Ile Ile Asn Leu Cys Glu Asp 
        195                 200                 205             


Ile Val Val Lys Arg Phe Met Phe Gly Lys Glu Ala Ile Thr Arg Leu 
    210                 215                 220                 


Arg Ser Arg Leu Ser Pro Asn His Asn Gly Lys Thr Ile Ser Arg Val 
225                 230                 235                 240 


Arg Val Val Cys Ala Val Ile Val Lys Ala Leu Met Gly Leu Glu Arg 
                245                 250                 255     


Ala Lys His Gly Lys Thr Arg Asp Phe Leu Ile Thr Gln Ser Ile Asn 
            260                 265                 270         


Met Arg Glu Arg Thr Lys Ala Pro Leu Gln Lys His Ala Cys Gly Asn 
        275                 280                 285             


Leu Ala Val Leu Ser Cys Thr Arg Arg Val Glu Ala Glu Glu Met Met 
    290                 295                 300                 


Glu Leu Gln Asn Leu Val Asn Leu Ile Gly Glu Ser Thr Glu Lys Asp 
305                 310                 315                 320 


Ile Ala His Tyr Ser Glu Leu Leu Ser His Asn Gln Phe Gly Arg Asp 
                325                 330                 335     


Ile Ile Val Asn Val Met Lys Ser Leu Met Gln Phe Leu Asp Pro Asp 
            340                 345                 350         


Ile Tyr Ser Val Cys Phe Thr Asp Trp Ser Lys Phe Arg Phe Tyr Glu 
        355                 360                 365             


Ala Asp Phe Gly Phe Gly Lys Pro Val Trp Thr Ala Val Gly Pro Gln 
    370                 375                 380                 


Arg Pro Ile Ile Thr Thr Ala Ile Leu Met Asn Asn Arg Glu Gly Asp 
385                 390                 395                 400 


Gly Ile Glu Ala Trp Leu His Leu Asn Lys Asn Asp Met Leu Ile Phe 
                405                 410                 415     


Glu Gln Asp Glu Glu Ile Lys Leu Phe Thr Thr 
            420                 425         


<210>  8
<211>  425
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric sequence comprising sequences from two ACTs from Coleus 
       forskohlii

<400>  8

Met Lys Val Glu Arg Phe Ser Arg Lys Phe Ile Lys Pro His Thr Pro 
1               5                   10                  15      


Thr Pro Glu Asn Leu Lys Lys Tyr Lys Leu Ser Leu Leu Asp Lys Cys 
            20                  25                  30          


Leu Gly His Asp Asn Phe Ala Ile Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Arg Asn Lys Ser Glu Leu Glu Glu Ser Leu Glu Lys Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg His Thr Met Asn Asp His Ile Val Asp 
65                  70                  75                  80  


Cys Ser Asp Val Gly Ala Val Phe Val Glu Ala Glu Ala Leu Asp Val 
                85                  90                  95      


Glu Leu Thr Met Asp Glu Leu Val Lys Asn Met Glu Ala Gln Thr Ile 
            100                 105                 110         


His His Leu Leu Pro Asn Gln Tyr Phe Ser Ala Asp Ala Pro Asn Pro 
        115                 120                 125             


Leu Leu Ser Ile Gln Val Thr His Phe Pro Ser Gly Gly Leu Ala Ile 
    130                 135                 140                 


Gly Ile Ala Val Ser His Ala Val Phe Asp Gly Phe Ser Leu Gly Val 
145                 150                 155                 160 


Phe Val Ala Ala Trp Ser Lys Ala Thr Met Asn Pro Asp Arg Lys Ile 
                165                 170                 175     


Lys Ile Thr Pro Ser Phe Asp Leu Pro Ser Leu Leu Pro Tyr Lys Asp 
            180                 185                 190         


Asp Asn Phe Gly Leu Thr Ala Ala Glu Ile Val Ser Gln Ser Glu Asp 
        195                 200                 205             


Ile Val Val Lys Arg Phe Ile Phe Gly Lys Glu Ala Ile Thr Arg Leu 
    210                 215                 220                 


Arg Ser Lys Leu Ser Pro Asn Arg Asn Gly Lys Lys Ile Ser Arg Val 
225                 230                 235                 240 


Arg Val Val Cys Ala Val Ile Val Lys Ala Leu Met Gly Leu Glu Arg 
                245                 250                 255     


Ala Lys Thr Arg Asp Phe Met Ile Cys Gln Gly Ile Asn Met Arg Glu 
            260                 265                 270         


Arg Thr Lys Ala Pro Leu Gln Lys His Ala Cys Gly Asn Leu Ala Val 
        275                 280                 285             


Ser Ser Tyr Thr Arg Arg Val Ala Ala Ala Glu Ala Glu Glu Leu Gln 
    290                 295                 300                 


Ser Leu Val Asn Leu Ile Gly Asp Ser Ile Glu Lys Ser Ile Ala Asp 
305                 310                 315                 320 


Tyr Ala Asp Ile Leu Ser Ser Asp Gln Asp Gly Arg His Ile Ile Ser 
                325                 330                 335     


Thr Met Met Lys Ser Phe Met Gln Phe Ala Ala Pro Asp Ile Lys Ala 
            340                 345                 350         


Ile Ser Phe Thr Asp Trp Ser Lys Phe Gly Phe Tyr Gln Val Asp Phe 
        355                 360                 365             


Gly Phe Gly Lys Pro Val Trp Thr Gly Val Arg Pro Glu Arg Pro Ile 
    370                 375                 380                 


Phe Ser Ala Ala Ile Leu Met Ser Asn Arg Glu Gly Asp Gly Ile Glu 
385                 390                 395                 400 


Ala Trp Leu His Leu Asp Lys Asn Asp Met Leu Ile Phe Glu Gln Asp 
                405                 410                 415     


Glu Glu Ile Lys Leu Leu Ile Thr Thr 
            420                 425 


<210>  9
<211>  426
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric sequence comprising sequences from Coleus forskohlii

<400>  9

Met Lys Val Glu Arg Phe Ser Arg Lys Phe Ile Lys Pro His Thr Pro 
1               5                   10                  15      


Thr Pro Glu Asn Leu Lys Lys Tyr Lys Leu Ser Leu Leu Asp Lys Cys 
            20                  25                  30          


Leu Gly His Asp Asn Phe Ala Ile Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Arg Asn Lys Ser Glu Leu Glu Glu Ser Leu Glu Lys Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg Tyr Thr Met Asn Asp His Ile Val Asp 
65                  70                  75                  80  


Cys Ser Asp Glu Gly Ala Val Phe Val Glu Ala Glu Ala Pro Asn Val 
                85                  90                  95      


Glu Leu Thr Val Asp Gln Leu Val Lys Asn Met Glu Ala Gln Thr Ile 
            100                 105                 110         


His Asp Phe Leu Pro Asp Gln Tyr Phe Pro Ala Asp Ala Pro Asn Pro 
        115                 120                 125             


Leu Leu Ser Ile Gln Val Thr His Phe Pro Cys Gly Gly Leu Ala Ile 
    130                 135                 140                 


Gly Ile Val Val Ser His Ala Val Phe Asp Gly Phe Ser Leu Gly Val 
145                 150                 155                 160 


Phe Leu Ala Ala Trp Ser Lys Ala Thr Met Asn Pro Glu Arg Lys Ile 
                165                 170                 175     


Glu Ile Thr Pro Ser Phe Asp Leu Pro Ser Leu Leu Pro Tyr Lys Asp 
            180                 185                 190         


Glu Ser Phe Gly Leu Asn Phe Ser Glu Ile Val Lys Ala Glu Asn Ile 
        195                 200                 205             


Val Val Lys Arg Leu Asn Phe Gly Lys Glu Ala Ile Thr Arg Leu Arg 
    210                 215                 220                 


Ser Arg Leu Ser Pro Asn His Asn Gly Lys Thr Ile Ser Arg Val Arg 
225                 230                 235                 240 


Val Val Cys Ala Leu Ile Val Lys Ala Leu Met Gly Leu Glu Leu Ala 
                245                 250                 255     


Lys His Gly Lys Thr Arg Asp Phe Met Ile Ser Gln Gly Ile Asn Met 
            260                 265                 270         


Arg Glu Arg Thr Lys Ala Pro Leu His Lys His Ala Cys Gly Asn Leu 
        275                 280                 285             


Ala Ile Leu Ser Cys Thr Arg Arg Val Glu Ala Glu Glu Met Met Asp 
    290                 295                 300                 


Leu Gln Asn Leu Val Asn Leu Ile Gly Glu Ser Thr Glu Lys Asp Ile 
305                 310                 315                 320 


Ala His Tyr Ser Glu Leu Leu Ser His Asn Gln Phe Gly Arg Asp Ile 
                325                 330                 335     


Ile Val Asn Val Met Lys Ser Leu Met Gln Phe Leu Asp Pro Asp Ile 
            340                 345                 350         


Tyr Ser Val Cys Phe Thr Asp Trp Ser Lys Phe Arg Phe Tyr Glu Ala 
        355                 360                 365             


Asp Phe Gly Phe Gly Lys Pro Val Trp Thr Ala Val Gly Pro Gln Arg 
    370                 375                 380                 


Pro Ile Ile Thr Thr Ala Ile Leu Met Asn Asn Arg Glu Gly Asp Gly 
385                 390                 395                 400 


Ile Glu Ala Trp Leu His Leu Asn Lys Asn Asp Met Leu Ile Phe Glu 
                405                 410                 415     


Gln Asp Glu Glu Ile Lys Leu Phe Thr Thr 
            420                 425     


<210>  10
<211>  433
<212>  PRT
<213>  Coleus forskohlii

<400>  10

Met Lys Val Glu Arg Phe Ser Arg Lys Leu Ile Lys Pro Val Thr Pro 
1               5                   10                  15      


Thr Pro Gln Asn Leu Lys Asn Phe Asn Leu Ser Ile Leu Asp Lys Cys 
            20                  25                  30          


Leu Pro Pro Ile Lys Phe Gly Val Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Gly Asn Lys Ser Glu Leu Glu Glu Ser Leu Lys Glu Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg His Thr Ile Asn Asp Pro Val Val Asp 
65                  70                  75                  80  


Cys Ser Asp Gln Gly Ala Val Phe Val Glu Ala Glu Ala Leu Asp Thr 
                85                  90                  95      


Glu Leu Thr Met Asp Gln Leu Val Leu Asn Lys Met Glu Ile Gln Lys 
            100                 105                 110         


Val Asp Gln Phe Leu Pro Asp Glu Cys Ile Gln Ala Asp Ala Pro Asn 
        115                 120                 125             


Pro Leu Leu Trp Ile Gln Val Thr His Phe Pro Ser Gly Gly Leu Ala 
    130                 135                 140                 


Ile Gly Val Ala Val Ser His Ser Val Phe Asp Ser Phe Ser Leu Gly 
145                 150                 155                 160 


Val Phe Ile Ala Ala Trp Ser Lys Ala Thr Met Asn Pro Gly Arg Met 
                165                 170                 175     


Ile Glu Ile Thr Pro Ser Phe Asp Val Pro Ser Leu Leu Pro Cys Lys 
            180                 185                 190         


Asp His Asp Phe Glu Ile Ala Leu Asn Glu Ile Thr Asp Gln Gly Glu 
        195                 200                 205             


Ser Phe Val Val Lys Arg Leu Val Phe Gly Lys Glu Ala Ile Thr Arg 
    210                 215                 220                 


Leu Arg Ser Lys Leu Ser Leu Asn Gln Asp Gly Lys Thr Ile Ser Arg 
225                 230                 235                 240 


Val Arg Val Val Gly Ala Val Leu Val Lys Ala Leu Ile Gly Leu Glu 
                245                 250                 255     


Cys Gly Lys His Gly Arg Arg Lys Asp Leu Val Ile Ser Leu Pro Val 
            260                 265                 270         


Asn Met Arg Glu Arg Thr Asn Thr Pro Leu Gln Asn Pro Lys His Ala 
        275                 280                 285             


Cys Gly Asn Leu Ala Val Ile Ser Leu Thr Arg Cys Val Ala Ala Ala 
    290                 295                 300                 


Glu Ala Glu Glu Met Gly Leu Gln Glu Leu Val Asn Leu Leu Gly Asp 
305                 310                 315                 320 


Ala Ile Gly Lys Ala Ile Ala Asp His Ala Glu Met Leu Ser Pro Asn 
                325                 330                 335     


Gln Glu Gly Cys Asp Ile Ile Ile Asn Asp Phe Lys Asn Phe Leu Thr 
            340                 345                 350         


Leu Phe Gly Thr Pro Asn Thr Asn Ile Ile Thr Leu Thr Asp Trp Ser 
        355                 360                 365             


Lys Phe Gly Phe Tyr Glu Ala Asp Phe Gly Phe Gly Lys Pro Val Trp 
    370                 375                 380                 


Thr Ser Ser Gly Gln Gln Ser Leu Ser Val Thr Thr Ile Val Leu Met 
385                 390                 395                 400 


Asn Asn Lys Glu Gly Asp Gly Ile Glu Ala Trp Leu His Leu Asn Lys 
                405                 410                 415     


Asn Asp Met Leu Phe Phe Glu Gln Asp Glu Glu Ile Lys Leu Phe Thr 
            420                 425                 430         


Thr 
    


<210>  11
<211>  1284
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  11
atgaaggtcg aaagattctc cagaaagttg attaagccac atactccaac tccagaaaac       60

ttgaagaagt acaagttgtc cttgttggat aagtgcttgg gtcatgataa tttcgccatc      120

gttttgttct acgaatccaa gccaagaaac aagtccgaat tggaagaatc cttggaaaag      180

gttttggttg acttttatcc attggctggt agatacacca tgaacgatca tatagttgat      240

tgctctgatg ttggtgccgt ttttgttgaa gctgaagctt tggatgttga attgaccatg      300

gatgaattgg tcaagaacat ggaagctcaa accatccatc atttgttgcc aaatcaatac      360

ttctctgctg atgctccaaa tcctttgttg tctattcaag ttacccattt cccatctggt      420

ggtttggcta ttggtattgc tgtttctcat gctgttttcg acggtttttc tttgggtgtt      480

ttcgttgctg cttggtctaa agctactatg aatccagata gaaagatcaa gatcacccca      540

tcttttgact tgccatcttt gttaccatac aaggatgata acttcggttt gactgctgct      600

gaaatcgttt ctcaatctga agatatcgtc gtcaagagat tcatcttcgg taaagaagct      660

atcactagat tgagatccaa gttgtctcca aacagaaacg gtaagaagat ctccagagtt      720

agagttgttt gtgccgttat agttaaggct ttgatgggtt tggaaagagc taaacacggt      780

aagactagag atttcttgat cacccaatcc atcaacatga gagaaagaac aaaagcccca      840

ttgcaaaaac atgcttgtgg taatttggct gttttgtctt gtaccagaag agttgaagcc      900

gaagaaatga tggaattgca aaacttggtt aacttgatcg gtgactctac cgaaaaggat      960

attgctgatt tcgccgaatt attgtcccca gatcaagttg gtagagacat cattatcaag     1020

atgatgaagt ccttcatgca attcttggac aacgacatct actctgtttg tttcactgat     1080

tggtctaagt tcgaattcta cgaagccgat tttggttttg gtaaaccagt ttggatggct     1140

gctggtccac aaagaccaat tatttctact gccatcttga tgtccgatag agaaggtgat     1200

ggtattgaag cttggttgca tttgaacaag aacgacatgt tgatcttcga acaagacgaa     1260

gaaatcaagt tgttcaccac ctga                                            1284


<210>  12
<211>  1284
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  12
atgaaggtcg aaagattctc cagaaagttg attaagccac atactccaac tccagaaaac       60

ttgaagaact acaagttgtc cttgttggat aagtgcttgg tccaagataa tttcgccgtt      120

gttttgttct acgaatccaa gccaagaaac aagtccgaat tggaagaatc cttggaaaag      180

gttttggttg acttttatcc attggctggt agatacacca tgaacgatca tatagttgat      240

tgctctgatg aaggtgccgt ttttgttgaa gctgaagctt tggatgctga attgactatg      300

gatcaattgg tcaagaacat ggaagcccaa accattcatc atttgttgcc agatcaatac      360

tttccagctg atgctccaat tcctttgttg tctattcaag ttacccattt cccatttggt      420

ggtttggcta ttgctatcgt tgtttctcat gctgttttcg acggtttttc tttgggtgtt      480

ttcgttgctg cttggtctaa agctactatt aacccagatg tcaagatcga aattacccca      540

tcttttgact tgccatcctt gttgccatac aaggacgatg attttggttt gaccgattgc      600

gaaatcatca acttgtgtga agatatcgtc gtcaagagat tcatgttcgg taaagaagct      660

atcaccagat tgagatctag attgtctcca aaccataacg gtaagaccat ctctagagtt      720

agagttgttt gtgccgttat cgttaaggct ttgatgggtt tggaaagagc taaacacggt      780

aaaaccagag atttcttgat cacccaatcc atcaacatga gagaaagaac aaaagcccca      840

ttgcaaaaac atgcttgtgg taatttggct gttttgtctt gtaccagaag agttgaagcc      900

gaagaaatga tggaattgca aaacttggtt aacttgatcg gtgaatccac cgaaaaggat      960

attgctcact actccgaatt attgtcccac aatcaattcg gtagagacat catcgttaac     1020

gtcatgaagt ctttgatgca attcttggat ccagacatct actctgtttg tttcactgat     1080

tggtctaagt tcagattcta cgaagctgat ttcggttttg gtaaaccagt ttggactgct     1140

gttggtccac aaagaccaat tattactacc gccattttga tgaacaacag agaaggtgat     1200

ggtattgaag cttggttgca tttgaacaag aacgacatgt tgatcttcga acaagacgaa     1260

gaaatcaagt tgttcaccac ctga                                            1284


<210>  13
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  13
atgaaggtcg aaagattctc cagaaagttc attaagccac atactccaac tccagaaaac       60

ttgaagaagt acaagttgtc cttgttggat aagtgcttgg gtcatgataa tttcgccatc      120

gttttgttct acgaatccaa gccaagaaac aagtccgaat tggaagaatc cttggaaaag      180

gttttggttg acttttatcc attggctggt agatacacca tgaacgatca tatagttgat      240

tgctctgatg ttggtgccgt ttttgttgaa gctgaagctt tggatgttga attgaccatg      300

gatgaattgg tcaagaacat ggaagctcaa accatccatc atttgttgcc aaatcaatac      360

ttctctgctg atgctccaaa tcctttgttg tctattcaag ttacccattt cccatctggt      420

ggtttggcta ttggtattgc tgtttctcat gctgttttcg acggtttttc tttgggtgtt      480

ttcgttgctg cttggtctaa agctactatg aatccagata gaaagatcaa gatcacccca      540

tcttttgact tgccatcttt gttaccatac aaggatgata acttcggttt gactgctgct      600

gaaatcgttt ctcaatctga agatatcgtc gtcaagagat tcatcttcgg taaagaagct      660

atcactagat tgagatccaa gttgtctcca aacagaaacg gtaagaagat ctccagagtt      720

agagttgttt gtgccgttat agttaaggct ttgatgggtt tggaaagagc taagactaga      780

gatttcatga tctgccaagg tatcaacatg agagaaagaa caaaagcccc attgcaaaaa      840

catgcttgtg gtaatttggc cgtttcttca tacactagaa gagttgctgc tgcagaagca      900

gaagaattgc aatctttggt taacttgatc ggtgactcca tcgaaaagtc tattgctgat      960

tacgccgata tcttgtcctc tgatcaagat ggtagacata tcatctccac catgatgaag     1020

tctttcatgc aatttgctgc cccagatatt aaggctattt ctttcactga ttggtctaag     1080

ttcggtttct accaagttga ttttggtttc ggtaaaccag tttggactgg tgttagacca     1140

gaaagaccaa ttttttccgc tgccattttg atgtctaaca gagaaggtga tggtattgaa     1200

gcttggttgc atttggataa gaacgacatg ttgatcttcg aacaagacga agaaatcaag     1260

ttgttgatca ccacctga                                                   1278


<210>  14
<211>  1281
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  14
atgaaggtcg aaagattctc cagaaagttc attaagccac atactccaac tccagaaaac       60

ttgaagaagt acaagttgtc cttgttggat aagtgcttgg gtcatgataa tttcgccatc      120

gttttgttct acgaatccaa gccaagaaac aagtccgaat tggaagaatc cttggaaaag      180

gttttggttg acttttatcc attggctggt agatacacca tgaacgatca tatagttgat      240

tgctctgatg aaggtgccgt ttttgttgaa gctgaagctc caaatgttga attgaccgtt      300

gatcaattgg tcaagaacat ggaagctcaa accatccatg atttcttgcc agatcaatac      360

tttccagctg atgctcctaa tcctttgttg tctattcaag ttacccattt cccatgtggt      420

ggtttggcta ttggtatagt tgtttctcat gctgttttcg acggtttctc tttgggtgtt      480

tttttggctg cttggtctaa ggctactatg aatccagaaa gaaagatcga aatcacccca      540

tcttttgact tgccatcttt gttgccttac aaggacgaat cttttggttt gaacttctcc      600

gaaatcgtta aggccgaaaa catcgttgtt aagagattga acttcggtaa agaagccatc      660

accagattga gatctagatt gtctccaaac cataacggta agaccatctc tagagttaga      720

gttgtttgtg ccttgattgt caaggctttg atgggtttgg aattggctaa acatggtaag      780

actagagact tcatgatctc ccaaggtatc aacatgagag aaagaacaaa agccccattg      840

cacaaacatg cttgtggtaa tttggccatt ttgtcttgta ccagaagagt tgaagccgaa      900

gaaatgatgg acttgcaaaa cttggttaac ttgatcggtg aatccaccga aaaggatatt      960

gctcactact ccgaattatt gtcccacaat caattcggta gagacatcat cgttaacgtt     1020

atgaagtcct tgatgcaatt cttggatcca gatatctact ctgtttgttt cactgactgg     1080

tccaagttca gattttacga agctgatttt ggtttcggta agccagtttg gactgctgtt     1140

ggtccacaaa gaccaattat tactaccgcc attttgatga acaacagaga aggtgatggt     1200

attgaagctt ggttgcattt gaacaagaac gacatgttga tcttcgaaca agacgaagaa     1260

atcaagttgt tcaccacctg a                                               1281


<210>  15

<400>  15
000

<210>  16
<211>  773
<212>  PRT
<213>  Coleus forskohlii

<400>  16

Met Lys Met Leu Met Ile Lys Ser Gln Phe Arg Val His Ser Ile Val 
1               5                   10                  15      


Ser Ala Trp Ala Asn Asn Ser Asn Lys Arg Gln Ser Leu Gly His Gln 
            20                  25                  30          


Ile Arg Arg Lys Gln Arg Ser Gln Val Thr Glu Cys Arg Val Ala Ser 
        35                  40                  45              


Leu Asp Ala Leu Asn Gly Ile Gln Lys Val Gly Pro Ala Thr Ile Gly 
    50                  55                  60                  


Thr Pro Glu Glu Glu Asn Lys Lys Ile Glu Asp Ser Ile Glu Tyr Val 
65                  70                  75                  80  


Lys Glu Leu Leu Lys Thr Met Gly Asp Gly Arg Ile Ser Val Ser Pro 
                85                  90                  95      


Tyr Asp Thr Ala Ile Val Ala Leu Ile Lys Asp Leu Glu Gly Gly Asp 
            100                 105                 110         


Gly Pro Glu Phe Pro Ser Cys Leu Glu Trp Ile Ala Gln Asn Gln Leu 
        115                 120                 125             


Ala Asp Gly Ser Trp Gly Asp His Phe Phe Cys Ile Tyr Asp Arg Val 
    130                 135                 140                 


Val Asn Thr Ala Ala Cys Val Val Ala Leu Lys Ser Trp Asn Val His 
145                 150                 155                 160 


Ala Asp Lys Ile Glu Lys Gly Ala Val Tyr Leu Lys Glu Asn Val His 
                165                 170                 175     


Lys Leu Lys Asp Gly Lys Ile Glu His Met Pro Ala Gly Phe Glu Phe 
            180                 185                 190         


Val Val Pro Ala Thr Leu Glu Arg Ala Lys Ala Leu Gly Ile Lys Gly 
        195                 200                 205             


Leu Pro Tyr Asp Asp Pro Phe Ile Arg Glu Ile Tyr Ser Ala Lys Gln 
    210                 215                 220                 


Thr Arg Leu Thr Lys Ile Pro Lys Gly Met Ile Tyr Glu Ser Pro Thr 
225                 230                 235                 240 


Ser Leu Leu Tyr Ser Leu Asp Gly Leu Glu Gly Leu Glu Trp Asp Lys 
                245                 250                 255     


Ile Leu Lys Leu Gln Ser Ala Asp Gly Ser Phe Ile Thr Ser Val Ser 
            260                 265                 270         


Ser Thr Ala Phe Val Phe Met His Thr Asn Asp Leu Lys Cys His Ala 
        275                 280                 285             


Phe Ile Lys Asn Ala Leu Thr Asn Cys Asn Gly Gly Val Pro His Thr 
    290                 295                 300                 


Tyr Pro Val Asp Ile Phe Ala Arg Leu Trp Ala Val Asp Arg Leu Gln 
305                 310                 315                 320 


Arg Leu Gly Ile Ser Arg Phe Phe Glu Pro Glu Ile Lys Tyr Leu Met 
                325                 330                 335     


Asp His Ile Asn Asn Val Trp Arg Glu Lys Gly Val Phe Ser Ser Arg 
            340                 345                 350         


His Ser Gln Phe Ala Asp Ile Asp Asp Thr Ser Met Gly Ile Arg Leu 
        355                 360                 365             


Leu Lys Met His Gly Tyr Asn Val Asn Pro Asn Ala Leu Glu His Phe 
    370                 375                 380                 


Lys Gln Lys Asp Gly Lys Phe Thr Cys Tyr Ala Asp Gln His Ile Glu 
385                 390                 395                 400 


Ser Pro Ser Pro Met Tyr Asn Leu Tyr Arg Ala Ala Gln Leu Arg Phe 
                405                 410                 415     


Pro Gly Glu Glu Ile Leu Gln Gln Ala Leu Gln Phe Ala Tyr Asn Phe 
            420                 425                 430         


Leu His Glu Asn Leu Ala Ser Asn His Phe Gln Glu Lys Trp Val Ile 
        435                 440                 445             


Ser Asp His Leu Ile Asp Glu Val Arg Ile Gly Leu Lys Met Pro Trp 
    450                 455                 460                 


Tyr Ala Thr Leu Pro Arg Val Glu Ala Ser Tyr Tyr Leu Gln His Tyr 
465                 470                 475                 480 


Gly Gly Ser Ser Asp Val Trp Ile Gly Lys Thr Leu Tyr Arg Met Pro 
                485                 490                 495     


Glu Ile Ser Asn Asp Thr Tyr Lys Ile Leu Ala Gln Leu Asp Phe Asn 
            500                 505                 510         


Lys Cys Gln Ala Gln His Gln Leu Glu Trp Met Ser Met Lys Glu Trp 
        515                 520                 525             


Tyr Gln Ser Asn Asn Val Lys Glu Phe Gly Ile Ser Lys Lys Glu Leu 
    530                 535                 540                 


Leu Leu Ala Tyr Phe Leu Ala Ala Ala Thr Met Phe Glu Pro Glu Arg 
545                 550                 555                 560 


Thr Gln Glu Arg Ile Met Trp Ala Lys Thr Gln Val Val Ser Arg Met 
                565                 570                 575     


Ile Thr Ser Phe Leu Asn Lys Glu Asn Thr Met Ser Phe Asp Leu Lys 
            580                 585                 590         


Ile Ala Leu Leu Thr Gln Pro Gln His Gln Ile Asn Gly Ser Glu Met 
        595                 600                 605             


Lys Asn Gly Leu Ala Gln Thr Leu Pro Ala Ala Phe Arg Gln Leu Leu 
    610                 615                 620                 


Lys Glu Phe Asp Lys Tyr Thr Arg His Gln Leu Arg Asn Thr Trp Asn 
625                 630                 635                 640 


Lys Trp Leu Met Lys Leu Lys Gln Gly Asp Asp Asn Gly Gly Ala Asp 
                645                 650                 655     


Ala Glu Leu Leu Ala Asn Thr Leu Asn Ile Cys Ala Gly His Asn Glu 
            660                 665                 670         


Asp Ile Leu Ser His Tyr Glu Tyr Thr Ala Leu Ser Ser Leu Thr Asn 
        675                 680                 685             


Lys Ile Cys Gln Arg Leu Ser Gln Ile Gln Asp Lys Lys Met Leu Glu 
    690                 695                 700                 


Ile Glu Glu Gly Ser Ile Lys Asp Lys Glu Met Glu Leu Glu Ile Gln 
705                 710                 715                 720 


Thr Leu Val Lys Leu Val Leu Gln Glu Thr Ser Gly Gly Ile Asp Arg 
                725                 730                 735     


Asn Ile Lys Gln Thr Phe Leu Ser Val Phe Lys Thr Phe Tyr Tyr Arg 
            740                 745                 750         


Ala Tyr His Asp Ala Lys Thr Ile Asp Ala His Ile Phe Gln Val Leu 
        755                 760                 765             


Phe Glu Pro Val Val 
    770             


<210>  17
<211>  598
<212>  PRT
<213>  Coleus forskohlii

<400>  17

Met Ser Ser Leu Ala Gly Asn Leu Arg Val Ile Pro Phe Ser Gly Asn 
1               5                   10                  15      


Arg Val Gln Thr Arg Thr Gly Ile Leu Pro Val His Gln Thr Pro Met 
            20                  25                  30          


Ile Thr Ser Lys Ser Ser Ala Ala Val Lys Cys Ser Leu Thr Thr Pro 
        35                  40                  45              


Thr Asp Leu Met Gly Lys Ile Lys Glu Val Phe Asn Arg Glu Val Asp 
    50                  55                  60                  


Thr Ser Pro Ala Ala Met Thr Thr His Ser Thr Asp Ile Pro Ser Asn 
65                  70                  75                  80  


Leu Cys Ile Ile Asp Thr Leu Gln Arg Leu Gly Ile Asp Gln Tyr Phe 
                85                  90                  95      


Gln Ser Glu Ile Asp Ala Val Leu His Asp Thr Tyr Arg Leu Trp Gln 
            100                 105                 110         


Leu Lys Lys Lys Asp Ile Phe Ser Asp Ile Thr Thr His Ala Met Ala 
        115                 120                 125             


Phe Arg Leu Leu Arg Val Lys Gly Tyr Glu Val Ala Ser Asp Glu Leu 
    130                 135                 140                 


Ala Pro Tyr Ala Asp Gln Glu Arg Ile Asn Leu Gln Thr Ile Asp Val 
145                 150                 155                 160 


Pro Thr Val Val Glu Leu Tyr Arg Ala Ala Gln Glu Arg Leu Thr Glu 
                165                 170                 175     


Glu Asp Ser Thr Leu Glu Lys Leu Tyr Val Trp Thr Ser Ala Phe Leu 
            180                 185                 190         


Lys Gln Gln Leu Leu Thr Asp Ala Ile Pro Asp Lys Lys Leu His Lys 
        195                 200                 205             


Gln Val Glu Tyr Tyr Leu Lys Asn Tyr His Gly Ile Leu Asp Arg Met 
    210                 215                 220                 


Gly Val Arg Arg Asn Leu Asp Leu Tyr Asp Ile Ser His Tyr Lys Ser 
225                 230                 235                 240 


Leu Lys Ala Ala His Arg Phe Tyr Asn Leu Ser Asn Glu Asp Ile Leu 
                245                 250                 255     


Ala Phe Ala Arg Gln Asp Phe Asn Ile Ser Gln Ala Gln His Gln Lys 
            260                 265                 270         


Glu Leu Gln Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp Thr 
        275                 280                 285             


Leu Lys Phe Gly Arg Asp Val Val Arg Ile Gly Asn Phe Leu Thr Ser 
    290                 295                 300                 


Ala Met Ile Gly Asp Pro Glu Leu Ser Asp Leu Arg Leu Ala Phe Ala 
305                 310                 315                 320 


Lys His Ile Val Leu Val Thr Arg Ile Asp Asp Phe Phe Asp His Gly 
                325                 330                 335     


Gly Pro Lys Glu Glu Ser Tyr Glu Ile Leu Glu Leu Val Lys Glu Trp 
            340                 345                 350         


Lys Glu Lys Pro Ala Gly Glu Tyr Val Ser Glu Glu Val Glu Ile Leu 
        355                 360                 365             


Phe Thr Ala Val Tyr Asn Thr Val Asn Glu Leu Ala Glu Met Ala His 
    370                 375                 380                 


Ile Glu Gln Gly Arg Ser Val Lys Asp Leu Leu Val Lys Leu Trp Val 
385                 390                 395                 400 


Glu Ile Leu Ser Val Phe Arg Ile Glu Leu Asp Thr Trp Thr Asn Asp 
                405                 410                 415     


Thr Ala Leu Thr Leu Glu Glu Tyr Leu Ser Gln Ser Trp Val Ser Ile 
            420                 425                 430         


Gly Cys Arg Ile Cys Ile Leu Ile Ser Met Gln Phe Gln Gly Val Lys 
        435                 440                 445             


Leu Ser Asp Glu Met Leu Gln Ser Glu Glu Cys Thr Asp Leu Cys Arg 
    450                 455                 460                 


Tyr Val Ser Met Val Asp Arg Leu Leu Asn Asp Val Gln Thr Phe Glu 
465                 470                 475                 480 


Lys Glu Arg Lys Glu Asn Thr Gly Asn Ser Val Ser Leu Leu Gln Ala 
                485                 490                 495     


Ala His Lys Asp Glu Arg Val Ile Asn Glu Glu Glu Ala Cys Ile Lys 
            500                 505                 510         


Val Lys Glu Leu Ala Glu Tyr Asn Arg Arg Lys Leu Met Gln Ile Val 
        515                 520                 525             


Tyr Lys Thr Gly Thr Ile Phe Pro Arg Lys Cys Lys Asp Leu Phe Leu 
    530                 535                 540                 


Lys Ala Cys Arg Ile Gly Cys Tyr Leu Tyr Ser Ser Gly Asp Glu Phe 
545                 550                 555                 560 


Thr Ser Pro Gln Gln Met Met Glu Asp Met Lys Ser Leu Val Tyr Glu 
                565                 570                 575     


Pro Leu Pro Ile Ser Pro Pro Glu Ala Asn Asn Ala Ser Gly Glu Lys 
            580                 585                 590         


Met Ser Cys Val Ser Asn 
        595             


<210>  18
<211>  587
<212>  PRT
<213>  Coleus forskohlii

<400>  18

Met Ser Ile Thr Ile Asn Leu Arg Val Ile Ala Phe Pro Gly His Gly 
1               5                   10                  15      


Val Gln Ser Arg Gln Gly Ile Phe Ala Val Met Glu Phe Pro Arg Asn 
            20                  25                  30          


Lys Asn Thr Phe Lys Ser Ser Phe Ala Val Lys Cys Ser Leu Ser Thr 
        35                  40                  45              


Pro Thr Asp Leu Met Gly Lys Ile Lys Glu Lys Leu Ser Glu Lys Val 
    50                  55                  60                  


Asp Asn Ser Val Ala Ala Met Ala Thr Asp Ser Ala Asp Met Pro Thr 
65                  70                  75                  80  


Asn Leu Cys Ile Val Asp Ser Leu Gln Arg Leu Gly Val Glu Lys Tyr 
                85                  90                  95      


Phe Gln Ser Glu Ile Asp Thr Val Leu Asp Asp Ala Tyr Arg Leu Trp 
            100                 105                 110         


Gln Leu Lys Gln Lys Asp Ile Phe Ser Asp Ile Thr Thr His Ala Met 
        115                 120                 125             


Ala Phe Arg Leu Leu Arg Val Lys Gly Tyr Asp Val Ser Ser Glu Glu 
    130                 135                 140                 


Leu Ala Pro Tyr Ala Asp Gln Glu Gly Met Asn Leu Gln Thr Ile Asp 
145                 150                 155                 160 


Leu Ala Ala Val Ile Glu Leu Tyr Arg Ala Ala Gln Glu Arg Val Ala 
                165                 170                 175     


Glu Glu Asp Ser Thr Leu Glu Lys Leu Tyr Val Trp Thr Ser Thr Phe 
            180                 185                 190         


Leu Lys Gln Gln Leu Leu Ala Gly Ala Ile Pro Asp Gln Lys Leu His 
        195                 200                 205             


Lys Gln Val Glu Tyr Tyr Leu Lys Asn Tyr His Gly Ile Leu Asp Arg 
    210                 215                 220                 


Met Gly Val Arg Lys Gly Leu Asp Leu Tyr Asp Ala Gly Tyr Tyr Lys 
225                 230                 235                 240 


Ala Leu Lys Ala Ala Asp Arg Leu Val Asp Leu Cys Asn Glu Asp Leu 
                245                 250                 255     


Leu Ala Phe Ala Arg Gln Asp Phe Asn Ile Asn Gln Ala Gln His Arg 
            260                 265                 270         


Lys Glu Leu Glu Gln Leu Gln Arg Trp Tyr Ala Asp Cys Arg Leu Asp 
        275                 280                 285             


Lys Leu Glu Phe Gly Arg Asp Val Val Arg Val Ser Asn Phe Leu Thr 
    290                 295                 300                 


Ser Ala Ile Leu Gly Asp Pro Glu Leu Ser Glu Val Arg Leu Val Phe 
305                 310                 315                 320 


Ala Lys His Ile Val Leu Val Thr Arg Ile Asp Asp Phe Phe Asp His 
                325                 330                 335     


Gly Gly Pro Arg Glu Glu Ser His Lys Ile Leu Glu Leu Ile Lys Glu 
            340                 345                 350         


Trp Lys Glu Lys Pro Ala Gly Glu Tyr Val Ser Lys Glu Val Glu Ile 
        355                 360                 365             


Leu Tyr Thr Ala Val Tyr Asn Thr Val Asn Glu Leu Ala Glu Arg Ala 
    370                 375                 380                 


Asn Val Glu Gln Gly Arg Asn Val Glu Pro Phe Leu Arg Thr Leu Trp 
385                 390                 395                 400 


Val Gln Ile Leu Ser Ile Phe Lys Ile Glu Leu Asp Thr Trp Ser Asp 
                405                 410                 415     


Asp Thr Ala Leu Thr Leu Asp Asp Tyr Leu Asn Asn Ser Trp Val Ser 
            420                 425                 430         


Ile Gly Cys Arg Ile Cys Ile Leu Met Ser Met Gln Phe Ile Gly Met 
        435                 440                 445             


Lys Leu Pro Glu Glu Met Leu Leu Ser Glu Glu Cys Val Asp Leu Cys 
    450                 455                 460                 


Arg His Val Ser Met Val Asp Arg Leu Leu Asn Asp Val Gln Thr Phe 
465                 470                 475                 480 


Glu Lys Glu Arg Lys Glu Asn Thr Gly Asn Ala Val Ser Leu Leu Leu 
                485                 490                 495     


Ala Ala His Lys Gly Glu Arg Ala Phe Ser Glu Glu Glu Ala Ile Ala 
            500                 505                 510         


Lys Ala Lys Tyr Leu Ala Asp Cys Asn Arg Arg Ser Leu Met Gln Ile 
        515                 520                 525             


Val Tyr Lys Thr Gly Thr Ile Phe Pro Arg Lys Cys Lys Asp Met Phe 
    530                 535                 540                 


Leu Lys Val Cys Arg Ile Gly Cys Tyr Leu Tyr Ala Ser Gly Asp Glu 
545                 550                 555                 560 


Phe Thr Ser Pro Gln Gln Met Met Glu Asp Met Lys Ser Leu Val Tyr 
                565                 570                 575     


Glu Pro Leu Gln Ile His Pro Pro Pro Ala Asn 
            580                 585         


<210>  19
<211>  498
<212>  PRT
<213>  Coleus forskohlii

<400>  19

Met Glu Leu Val Glu Val Ile Val Val Val Val Gly Ala Ala Ala Leu 
1               5                   10                  15      


Gly Val Val Leu Trp Ser His Leu Lys Pro Glu Gly Arg Lys Leu Pro 
            20                  25                  30          


Pro Gly Pro Ser Pro Leu Pro Ile Phe Gly Asn Ile Phe Gln Leu Thr 
        35                  40                  45              


Gly Pro Asn Thr Cys Glu Ser Phe Ala Asn Leu Ser Lys Lys Tyr Gly 
    50                  55                  60                  


Pro Val Met Ser Leu Arg Leu Gly Ser Leu Phe Thr Val Val Ile Ser 
65                  70                  75                  80  


Ser Pro Glu Met Ala Lys Glu Val Leu Thr Asn Thr Asp Phe Leu Glu 
                85                  90                  95      


Arg Pro Leu Met Gln Ala Val His Ala His Asp His Ala Gln Phe Ser 
            100                 105                 110         


Ile Ala Phe Leu Pro Val Thr Thr Pro Lys Trp Lys Gln Leu Arg Arg 
        115                 120                 125             


Ile Cys Gln Glu Gln Met Phe Ala Ser Arg Ile Leu Glu Lys Ser Gln 
    130                 135                 140                 


Pro Leu Arg His Gln Lys Leu Gln Glu Leu Ile Asp His Val Gln Lys 
145                 150                 155                 160 


Cys Cys Asp Ala Gly Arg Ala Val Thr Ile Arg Asp Ala Ala Phe Ala 
                165                 170                 175     


Thr Thr Leu Asn Leu Met Ser Val Thr Met Phe Ser Ala Asp Ala Thr 
            180                 185                 190         


Glu Leu Asp Ser Ser Val Thr Ala Glu Leu Arg Glu Leu Met Ala Gly 
        195                 200                 205             


Val Val Thr Val Leu Gly Thr Pro Asn Phe Ala Asp Phe Phe Pro Ile 
    210                 215                 220                 


Leu Lys Tyr Leu Asp Pro Gln Gly Val Arg Arg Lys Ala His Phe His 
225                 230                 235                 240 


Tyr Gly Lys Met Phe Asp His Ile Lys Ser Arg Met Ala Glu Arg Val 
                245                 250                 255     


Glu Leu Lys Lys Ala Asn Pro Asn His Leu Lys His Asp Asp Phe Leu 
            260                 265                 270         


Glu Lys Ile Leu Asp Ile Ser Leu Arg Arg Asp Tyr Glu Leu Thr Ile 
        275                 280                 285             


Gln Asp Ile Thr His Leu Leu Val Asp Leu Tyr Val Ala Gly Ser Glu 
    290                 295                 300                 


Ser Thr Val Met Ser Ile Glu Trp Ile Met Ser Glu Leu Met Leu His 
305                 310                 315                 320 


Pro Gln Ser Leu Ala Lys Leu Lys Ala Glu Leu Arg Ser Val Met Gly 
                325                 330                 335     


Glu Arg Lys Met Ile Gln Glu Ser Glu Asp Ile Ser Arg Leu Pro Phe 
            340                 345                 350         


Leu Asn Ala Val Ile Lys Glu Thr Leu Arg Leu His Pro Pro Gly Pro 
        355                 360                 365             


Leu Leu Phe Pro Arg Gln Asn Thr Asn Asp Val Glu Leu Asn Gly Tyr 
    370                 375                 380                 


Phe Ile Pro Lys Gly Thr Gln Ile Leu Val Asn Glu Trp Ala Ile Gly 
385                 390                 395                 400 


Arg Asp Pro Ser Val Trp Pro Asn Pro Glu Ser Phe Val Pro Glu Arg 
                405                 410                 415     


Phe Leu Asp Lys Asn Ile Asp Tyr Lys Gly Gln Asp Pro Gln Leu Val 
            420                 425                 430         


Pro Phe Gly Ser Gly Arg Arg Ile Cys Leu Gly Ile Pro Ile Ala His 
        435                 440                 445             


Arg Met Val His Ser Thr Val Ala Ala Leu Ile His Asn Phe Glu Trp 
    450                 455                 460                 


Lys Phe Ala Pro Asp Gly Ser Glu Tyr Asn Arg Glu Leu Phe Ser Gly 
465                 470                 475                 480 


Pro Ala Leu Arg Arg Glu Val Pro Leu Asn Leu Ile Pro Leu Asn Pro 
                485                 490                 495     


Ser Phe 
        


<210>  20
<211>  492
<212>  PRT
<213>  Coleus forskohlii

<400>  20

Met Glu Thr Ile Thr Leu Leu Leu Ala Leu Phe Phe Ile Ala Leu Thr 
1               5                   10                  15      


Tyr Phe Ile Ser Ser Arg Arg Arg Arg Asn Leu Pro Pro Gly Pro Phe 
            20                  25                  30          


Pro Leu Pro Ile Ile Gly Asn Met Leu Gln Leu Gly Ser Lys Pro His 
        35                  40                  45              


Gln Ser Phe Ala Gln Leu Ser Lys Lys Tyr Gly Pro Leu Met Ser Ile 
    50                  55                  60                  


His Leu Gly Ser Leu Tyr Thr Val Ile Val Ser Ser Pro Glu Met Ala 
65                  70                  75                  80  


Lys Glu Ile Leu Gln Lys His Gly Gln Val Phe Ser Gly Arg Thr Ile 
                85                  90                  95      


Ala Gln Ala Val His Ala Cys Asp His Asp Lys Ile Ser Met Gly Phe 
            100                 105                 110         


Leu Pro Val Ala Asn Thr Trp Arg Asp Met Arg Lys Ile Cys Lys Glu 
        115                 120                 125             


Gln Met Phe Ser His His Ser Leu Glu Ala Ser Glu Glu Leu Arg His 
    130                 135                 140                 


Gln Lys Leu Gln Gln Leu Leu Asp Tyr Ala Gln Lys Cys Cys Glu Ala 
145                 150                 155                 160 


Gly Arg Ala Val Asp Ile Arg Glu Ala Ser Phe Ile Thr Thr Leu Asn 
                165                 170                 175     


Leu Met Ser Ala Thr Met Phe Ser Thr Gln Ala Thr Glu Phe Asp Ser 
            180                 185                 190         


Glu Ala Thr Lys Glu Phe Lys Glu Ile Ile Glu Gly Val Ala Thr Ile 
        195                 200                 205             


Val Gly Val Ala Asn Phe Ala Asp Tyr Phe Pro Ile Leu Lys Pro Phe 
    210                 215                 220                 


Asp Leu Gln Gly Ile Lys Arg Arg Ala Asp Gly Tyr Phe Gly Arg Leu 
225                 230                 235                 240 


Leu Lys Leu Ile Glu Gly Tyr Leu Asn Glu Arg Leu Glu Ser Arg Arg 
                245                 250                 255     


Leu Asn Pro Asp Ala Pro Arg Lys Lys Asp Phe Leu Glu Thr Leu Val 
            260                 265                 270         


Asp Ile Ile Glu Ala Asn Glu Tyr Lys Leu Thr Thr Glu His Leu Thr 
        275                 280                 285             


His Leu Met Leu Asp Leu Phe Val Gly Gly Ser Glu Thr Asn Thr Thr 
    290                 295                 300                 


Ser Leu Glu Trp Ile Met Ser Glu Leu Val Ile Asn Pro Asp Lys Met 
305                 310                 315                 320 


Ala Lys Val Lys Glu Glu Leu Lys Ser Val Val Gly Asp Glu Lys Leu 
                325                 330                 335     


Val Asn Glu Ser Asp Met Pro Arg Leu Pro Tyr Leu Gln Ala Val Ile 
            340                 345                 350         


Lys Glu Val Leu Arg Ile His Pro Pro Gly Pro Leu Leu Leu Pro Arg 
        355                 360                 365             


Lys Ala Glu Ser Asp Gln Val Val Asn Gly Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Gln Ile Leu Phe Asn Ala Trp Ala Met Gly Arg Asp Pro Thr Ile 
385                 390                 395                 400 


Trp Lys Asp Pro Glu Ser Phe Glu Pro Glu Arg Phe Leu Asn Gln Ser 
                405                 410                 415     


Ile Asp Phe Lys Gly Gln Asp Phe Glu Leu Ile Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Ile Cys Pro Gly Met Pro Leu Ala Asn Arg Ile Leu His Met 
        435                 440                 445             


Thr Thr Ala Thr Leu Val His Asn Phe Asp Trp Lys Leu Glu Glu Gly 
    450                 455                 460                 


Thr Ala Asp Ala Asp His Lys Gly Glu Leu Phe Gly Leu Ala Val Arg 
465                 470                 475                 480 


Arg Ala Thr Pro Leu Arg Ile Ile Pro Leu Lys Pro 
                485                 490         


<210>  21
<211>  495
<212>  PRT
<213>  Coleus forskohlii

<400>  21

Met Glu Leu Val Gln Val Ile Ala Val Val Ala Val Val Val Val Leu 
1               5                   10                  15      


Trp Ser Gln Leu Lys Arg Lys Gly Arg Lys Leu Pro Pro Gly Pro Ser 
            20                  25                  30          


Pro Leu Pro Ile Val Gly Asn Ile Phe Gln Leu Ser Gly Lys Asn Ile 
        35                  40                  45              


Asn Glu Ser Phe Ala Lys Leu Ser Lys Ile Tyr Gly Pro Val Met Ser 
    50                  55                  60                  


Leu Arg Leu Gly Ser Leu Leu Thr Val Ile Ile Ser Ser Pro Glu Met 
65                  70                  75                  80  


Ala Lys Glu Val Leu Thr Ser Lys Asp Phe Ala Asn Arg Pro Leu Thr 
                85                  90                  95      


Glu Ala Ala His Ala His Gly His Ser Lys Phe Ser Val Gly Phe Val 
            100                 105                 110         


Pro Val Ser Asp Pro Lys Trp Lys Gln Met Arg Arg Val Cys Gln Glu 
        115                 120                 125             


Glu Met Phe Ala Ser Arg Ile Leu Glu Asn Ser Gln Gln Arg Arg His 
    130                 135                 140                 


Gln Lys Leu Gln Glu Leu Ile Asp His Val Gln Glu Ser Arg Asp Ala 
145                 150                 155                 160 


Gly Arg Ala Val Thr Ile Arg Asp Pro Val Phe Ala Thr Thr Leu Asn 
                165                 170                 175     


Ile Met Ser Leu Thr Leu Phe Ser Ala Asp Ala Thr Glu Phe Ser Ser 
            180                 185                 190         


Ser Ala Thr Ala Glu Leu Arg Asp Ile Met Ala Gly Val Val Ser Val 
        195                 200                 205             


Leu Gly Ala Ala Asn Leu Ala Asp Phe Phe Pro Ile Leu Lys Tyr Phe 
    210                 215                 220                 


Asp Pro Gln Gly Met Arg Arg Lys Ala Asp Leu His Tyr Gly Arg Leu 
225                 230                 235                 240 


Ile Asp His Ile Lys Ser Arg Met Asp Lys Arg Ser Glu Leu Lys Lys 
                245                 250                 255     


Ala Asn Pro Asn His Pro Lys His Asp Asp Phe Leu Glu Lys Ile Ile 
            260                 265                 270         


Asp Ile Thr Ile Gln Arg Asn Tyr Asp Leu Thr Ile Asn Glu Ile Thr 
        275                 280                 285             


His Leu Leu Val Asp Leu Tyr Leu Ala Gly Ser Glu Ser Thr Val Met 
    290                 295                 300                 


Thr Ile Glu Trp Thr Met Ala Glu Leu Met Leu Arg Pro Glu Ser Leu 
305                 310                 315                 320 


Ala Lys Leu Lys Ala Glu Leu Arg Ser Val Met Gly Glu Arg Lys Met 
                325                 330                 335     


Ile Gln Glu Ser Asp Asp Ile Ser Arg Leu Pro Tyr Leu Asn Gly Ala 
            340                 345                 350         


Ile Lys Glu Ala Leu Arg Leu His Pro Pro Gly Pro Leu Leu Phe Ala 
        355                 360                 365             


Arg Lys Ser Glu Ile Asp Val Glu Leu Ser Gly Tyr Phe Ile Pro Lys 
    370                 375                 380                 


Gly Thr Gln Ile Leu Val Asn Glu Trp Gly Met Gly Arg Asp Pro Ser 
385                 390                 395                 400 


Val Trp Pro Asn Pro Glu Cys Phe Gln Pro Glu Arg Phe Leu Asp Lys 
                405                 410                 415     


Asn Ile Asp Tyr Lys Gly Gln Asp Pro Gln Leu Ile Pro Phe Gly Ala 
            420                 425                 430         


Gly Arg Arg Ile Cys Pro Gly Ile Pro Ile Ala His Arg Val Val His 
        435                 440                 445             


Ser Val Val Ala Ala Leu Val His Asn Phe Asp Trp Glu Phe Ala Pro 
    450                 455                 460                 


Gly Gly Ser Gln Cys Asn Asn Glu Phe Phe Thr Gly Ala Ala Leu Val 
465                 470                 475                 480 


Arg Glu Val Pro Leu Lys Leu Ile Pro Leu Asn Pro Pro Ser Ile 
                485                 490                 495 


<210>  22
<211>  493
<212>  PRT
<213>  Coleus forskohlii

<400>  22

Met Glu Thr Met Thr Leu Leu Leu Pro Leu Phe Phe Ile Ala Leu Thr 
1               5                   10                  15      


Tyr Phe Leu Ser Trp Arg Arg Arg Arg Asn Leu Pro Pro Gly Pro Phe 
            20                  25                  30          


Pro Leu Pro Ile Ile Gly Asn Leu Leu Gln Ile Gly Ser Lys Pro His 
        35                  40                  45              


Gln Ser Phe Ala Gln Leu Ser Lys Lys Tyr Gly Pro Leu Met Ser Val 
    50                  55                  60                  


Gln Leu Gly Ser Val Tyr Thr Val Ile Ala Ser Ser Pro Glu Met Ala 
65                  70                  75                  80  


Lys Glu Ile Leu Gln Lys His Gly Gln Val Phe Ser Gly Arg Thr Ile 
                85                  90                  95      


Ala Gln Ala Ala Gln Ala Cys Gly His Asp Gln Ile Ser Ile Gly Phe 
            100                 105                 110         


Leu Pro Val Ala Thr Thr Trp Arg Asp Met Arg Lys Ile Cys Lys Glu 
        115                 120                 125             


Gln Met Phe Ser His His Ser Leu Glu Ser Ser Lys Glu Leu Arg His 
    130                 135                 140                 


Glu Lys Leu Gln Lys Leu Leu Asp Tyr Ala Gln Lys Cys Cys Glu Ala 
145                 150                 155                 160 


Gly Arg Ala Val Asp Ile Arg Glu Ala Ala Phe Ile Thr Thr Leu Asn 
                165                 170                 175     


Leu Met Ser Ala Thr Leu Phe Ser Thr Gln Ala Thr Glu Phe Asp Ser 
            180                 185                 190         


Glu Ala Thr Lys Glu Phe Lys Glu Val Ile Glu Gly Val Ala Val Ile 
        195                 200                 205             


Val Gly Glu Pro Asn Phe Ala Asp Tyr Phe Pro Ile Leu Lys Pro Phe 
    210                 215                 220                 


Asp Leu Gln Gly Ile Lys Arg Arg Ala Asn Ser Tyr Phe Gly Arg Leu 
225                 230                 235                 240 


Leu Lys Leu Met Glu Arg Tyr Leu Asn Glu Arg Leu Glu Ser Arg Arg 
                245                 250                 255     


Leu Asn Pro Asp Ala Pro Lys Lys Asn Asp Phe Leu Glu Thr Leu Val 
            260                 265                 270         


Asp Ile Ile Gln Ala Asp Glu Tyr Lys Leu Thr Thr Asp His Val Thr 
        275                 280                 285             


His Leu Met Leu Asp Leu Phe Val Gly Gly Ser Glu Thr Ser Ala Thr 
    290                 295                 300                 


Ser Leu Glu Trp Ile Met Ser Glu Leu Val Ser Asn Pro Ser Lys Leu 
305                 310                 315                 320 


Ala Lys Val Lys Ala Glu Leu Lys Ser Val Val Gly Glu Lys Lys Val 
                325                 330                 335     


Val Ser Glu Ser Glu Met Ala Arg Leu Pro Tyr Leu Gln Ala Val Ile 
            340                 345                 350         


Lys Glu Val Leu Arg Leu His Pro Pro Gly Pro Leu Leu Leu Pro Arg 
        355                 360                 365             


Lys Ala Gly Ser Asp Gln Val Val Asn Gly Tyr Leu Ile Pro Lys Gly 
    370                 375                 380                 


Thr Gln Leu Leu Phe Asn Val Trp Ala Met Gly Arg Asp Pro Ser Ile 
385                 390                 395                 400 


Trp Lys Asn Pro Glu Ser Phe Glu Pro Glu Arg Phe Leu Asn Gln Asn 
                405                 410                 415     


Ile Asp Tyr Lys Gly Gln Asp Phe Glu Leu Ile Pro Phe Gly Ser Gly 
            420                 425                 430         


Arg Arg Ile Cys Pro Gly Met Pro Leu Ala Asp Arg Ile Met His Met 
        435                 440                 445             


Thr Thr Ala Thr Leu Val His Asn Phe Asp Trp Lys Leu Glu Asp Gly 
    450                 455                 460                 


Ala Gly Asp Ala Asp His Lys Gly Asp Asp Pro Phe Gly Leu Ala Ile 
465                 470                 475                 480 


Arg Arg Ala Thr Pro Leu Arg Ile Ile Pro Leu Lys Pro 
                485                 490             


<210>  23
<211>  493
<212>  PRT
<213>  Coleus forskohlii

<400>  23

Met Glu Ser Met Asn Ala Leu Val Val Gly Leu Leu Leu Ile Ala Leu 
1               5                   10                  15      


Thr Ile Leu Phe Ser Leu Arg Arg Arg Arg Asn Leu Ala Pro Gly Pro 
            20                  25                  30          


Tyr Pro Phe Pro Ile Ile Gly Asn Met Leu Gln Leu Gly Thr Lys Pro 
        35                  40                  45              


His Gln Ser Phe Ala Gln Leu Ser Lys Lys Tyr Gly Pro Leu Met Ser 
    50                  55                  60                  


Ile His Leu Gly Ser Leu Tyr Thr Val Ile Val Ser Ser Pro Glu Met 
65                  70                  75                  80  


Ala Lys Glu Ile Leu Gln Lys His Gly Gln Val Phe Ser Gly Arg Thr 
                85                  90                  95      


Ile Ala Gln Ala Val His Ala Cys Asp His Asp Lys Ile Ser Met Gly 
            100                 105                 110         


Phe Leu Pro Val Ser Asn Thr Trp Arg Asp Met Arg Lys Ile Cys Lys 
        115                 120                 125             


Glu Gln Met Phe Ser His His Ser Leu Glu Gly Ser Gln Gly Leu Arg 
    130                 135                 140                 


Gln Gln Lys Leu Leu Gln Leu Leu Asp Tyr Ala Gln Lys Cys Cys Glu 
145                 150                 155                 160 


Thr Gly Arg Ala Val Asp Ile Arg Glu Ala Ser Phe Ile Thr Thr Leu 
                165                 170                 175     


Asn Leu Met Ser Ala Thr Met Phe Ser Thr Gln Ala Thr Glu Phe Glu 
            180                 185                 190         


Ser Lys Ser Thr Gln Glu Phe Lys Glu Ile Ile Glu Gly Val Ala Thr 
        195                 200                 205             


Ile Val Gly Val Ala Asn Phe Gly Asp Tyr Phe Pro Ile Leu Lys Pro 
    210                 215                 220                 


Phe Asp Leu Gln Gly Ile Lys Arg Lys Ala Asp Gly Tyr Phe Gly Arg 
225                 230                 235                 240 


Leu Leu Lys Leu Ile Glu Gly Tyr Leu Asn Glu Arg Leu Glu Ser Arg 
                245                 250                 255     


Lys Ser Asn Pro Asn Ala Pro Arg Lys Asn Asp Phe Leu Glu Thr Val 
            260                 265                 270         


Val Asp Ile Leu Glu Ala Asn Glu Tyr Lys Leu Ser Val Asp His Leu 
        275                 280                 285             


Thr His Leu Met Leu Asp Leu Phe Val Gly Gly Ser Glu Thr Asn Thr 
    290                 295                 300                 


Thr Ser Leu Glu Trp Thr Met Ser Glu Leu Val Asn Asn Pro Asp Lys 
305                 310                 315                 320 


Met Ala Lys Leu Lys Gln Glu Leu Lys Ser Val Val Gly Glu Arg Lys 
                325                 330                 335     


Leu Val Asp Glu Ser Glu Met Pro Arg Leu Pro Tyr Leu Gln Ala Val 
            340                 345                 350         


Ile Lys Glu Ser Leu Arg Ile His Pro Pro Gly Pro Leu Leu Leu Pro 
        355                 360                 365             


Arg Lys Ala Glu Thr Asp Gln Glu Val Asn Gly Tyr Leu Ile Pro Lys 
    370                 375                 380                 


Gly Thr Gln Ile Leu Phe Asn Val Trp Ala Met Gly Arg Asp Pro Ser 
385                 390                 395                 400 


Ile Trp Lys Asp Pro Glu Ser Phe Glu Pro Glu Arg Phe Leu Asn Gln 
                405                 410                 415     


Asn Ile Asp Phe Lys Gly Gln Asp Phe Glu Leu Ile Pro Phe Gly Ser 
            420                 425                 430         


Gly Arg Arg Ile Cys Pro Gly Met Pro Leu Ala Asn Arg Ile Leu His 
        435                 440                 445             


Met Ala Thr Ala Thr Met Val His Asn Phe Asp Trp Lys Leu Glu Gln 
    450                 455                 460                 


Gly Thr Asp Glu Ala Asp Ala Lys Gly Glu Leu Phe Gly Leu Ala Val 
465                 470                 475                 480 


Arg Arg Ala Val Pro Leu Arg Ile Ile Pro Leu Gln Pro 
                485                 490             


<210>  24
<211>  424
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric sequence comprising sequences from two ACTs from Coleus 
       forskohlii

<400>  24

Met Lys Val Glu Arg Phe Ser Arg Lys Phe Ile Lys Pro His Thr Pro 
1               5                   10                  15      


Thr Pro Glu Asn Leu Lys Lys Tyr Lys Leu Ser Leu Leu Asp Lys Cys 
            20                  25                  30          


Leu Gly His Asp Asn Phe Ala Ile Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Arg Asn Lys Ser Glu Leu Glu Glu Ser Leu Glu Lys Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg His Thr Met Asn Asp His Ile Val Asp 
65                  70                  75                  80  


Cys Ser Asp Val Gly Ala Val Phe Val Glu Ala Glu Ala Leu Asp Val 
                85                  90                  95      


Glu Leu Thr Met Asp Glu Leu Val Lys Asn Met Glu Ala Gln Thr Ile 
            100                 105                 110         


His His Leu Leu Pro Asn Gln Tyr Phe Ser Ala Asp Ala Pro Asn Pro 
        115                 120                 125             


Leu Leu Ser Ile Gln Val Thr His Phe Pro Ser Gly Gly Leu Ala Ile 
    130                 135                 140                 


Gly Ile Ala Val Ser His Ala Val Phe Asp Gly Phe Ser Leu Gly Val 
145                 150                 155                 160 


Phe Val Ala Ala Trp Ser Lys Ala Thr Met Asn Pro Asp Arg Lys Ile 
                165                 170                 175     


Lys Ile Thr Pro Ser Phe Asp Leu Pro Ser Leu Leu Pro Tyr Lys Asp 
            180                 185                 190         


Asp Asn Phe Gly Leu Thr Ala Ala Glu Ile Val Ser Gln Ser Glu Asp 
        195                 200                 205             


Ile Val Val Lys Arg Phe Ile Phe Gly Lys Glu Ala Ile Thr Arg Leu 
    210                 215                 220                 


Arg Ser Lys Leu Ser Pro Asn Arg Asn Gly Lys Lys Ile Ser Arg Val 
225                 230                 235                 240 


Arg Val Val Cys Ala Val Ile Val Lys Ala Leu Met Gly Leu Glu Arg 
                245                 250                 255     


Ala Lys Thr Arg Asp Phe Met Ile Cys Gln Gly Ile Asn Met Arg Glu 
            260                 265                 270         


Arg Thr Lys Ala Pro Leu Gln Lys His Ala Cys Gly Asn Leu Ala Val 
        275                 280                 285             


Ser Ser Tyr Thr Arg Arg Val Ala Ala Ala Glu Ala Glu Glu Leu Gln 
    290                 295                 300                 


Ser Leu Val Asn Leu Ile Gly Asp Ser Ile Glu Lys Ser Ile Ala Asp 
305                 310                 315                 320 


Tyr Ala Asp Ile Leu Ser Ser Asp Gln Asp Gly Arg His Ile Ile Ser 
                325                 330                 335     


Thr Met Met Lys Ser Phe Met Gln Phe Ala Ala Pro Asp Ile Lys Ala 
            340                 345                 350         


Ile Ser Phe Thr Asp Trp Ser Lys Phe Gly Phe Tyr Gln Val Asp Phe 
        355                 360                 365             


Gly Phe Gly Lys Pro Val Trp Thr Gly Val Arg Pro Glu Arg Pro Ile 
    370                 375                 380                 


Phe Ser Ala Ala Ile Leu Met Ser Asn Arg Glu Gly Asp Gly Ile Glu 
385                 390                 395                 400 


Ala Trp Leu His Leu Asp Lys Asn Asp Met Leu Ile Phe Glu Gln Asp 
                405                 410                 415     


Glu Glu Ile Lys Leu Phe Thr Thr 
            420                 


<210>  25
<211>  1275
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric sequence comprising sequences from two ACTs from Coleus 
       forskohlii

<400>  25
atgaaggtgg aaagatttag caggaaattc ataaaaccac acaccccgac ccccgaaaat       60

ctgaagaagt ataagctttc tcttttagac aaatgcttgg ggcacgataa ttttgctatt      120

gttctgtttt acgaatcgaa accaagaaac aagagtgagt tggaagaatc actggaaaaa      180

gtcctggtgg atttctaccc tcttgctgga agacacacca tgaatgatca catagttgat      240

tgcagtgatg tgggcgccgt gtttgtcgaa gcagaagctc tagacgtcga gctgacgatg      300

gatgagctcg ttaagaacat ggaggcccag actatccatc atctccttcc caatcaatat      360

ttctcagctg atgctccaaa tccactcttg tcaatccagg tgacacattt cccatctggt      420

ggcctagcaa ttggcatcgc cgtttctcac gctgtcttcg atggtttttc gctgggggtg      480

ttcgtcgccg cctggtcgaa ggccaccatg aacccagatc ggaagatcaa aatcacaccg      540

tctttcgatc ttccctcgtt gcttccttac aaggatgaca attttggatt aactgccgcc      600

gaaattgtca gccagagtga agatattgtt gttaagaggt ttattttcgg gaaggaggca      660

ataacgaggt tgagatcaaa gctaagccca aatcgcaatg ggaaaaagat ctctcgtgtt      720

cgagtggtgt gtgccgttat agtgaaagcc ttgatgggcc tggaacgcgc caaaacaaga      780

gatttcatga tctgtcaagg gatcaacatg cgtgagagaa caaaggcacc tctacagaag      840

catgcttgtg ggaatctggc ggtctcgtct tacacgcgac gtgtagccgc agcagaagcc      900

gaggagctgc agagtttggt aaatctaata ggtgattcta ttgagaagag catagctgat      960

tatgctgata ttctttcttc tgatcaagat gggcgtcata tcatcagcac gatgatgaaa     1020

tctttcatgc aattcgcggc tcctgacata aaagctatat ccttcactga ttggagtaag     1080

tttggattct accaagttga ttttgggttc gggaagcctg tttggacggg tgttcggccc     1140

gaacgcccaa tctttagcgc cgctattctc atgagcaaca gagagggtga tggaattgag     1200

gcatggcttc atcttgacaa aaatgacatg cttatcttcg agcaagatga agaaatcaaa     1260

ttatttacta cctaa                                                      1275


<210>  26
<211>  424
<212>  PRT
<213>  Coleus forskohlii

<400>  26

Met Lys Val Glu Arg Ile Ser Arg Lys Phe Ile Lys Pro Tyr Thr Pro 
1               5                   10                  15      


Thr Pro Gln Asn Leu Lys Lys Tyr Lys Leu Ser Leu Leu Asp Lys Cys 
            20                  25                  30          


Met Gly His Met Asp Phe Ala Val Val Leu Phe Tyr Glu Ser Lys Pro 
        35                  40                  45              


Arg Asn Lys Asn Glu Leu Glu Glu Ser Leu Glu Lys Val Leu Val Asp 
    50                  55                  60                  


Phe Tyr Pro Leu Ala Gly Arg Tyr Thr Met Asn Asp His Ile Val Asp 
65                  70                  75                  80  


Cys Ser Asp Glu Gly Ala Val Phe Val Glu Ala Glu Ala Pro Asn Val 
                85                  90                  95      


Glu Leu Thr Val Asp Gln Leu Val Lys Asn Met Glu Ala Gln Thr Ile 
            100                 105                 110         


His Asp Phe Leu Pro Asp Gln Tyr Phe Pro Ala Asp Ala Pro Asn Pro 
        115                 120                 125             


Leu Leu Ser Ile Gln Val Thr His Phe Pro Cys Gly Gly Leu Ala Ile 
    130                 135                 140                 


Gly Ile Val Val Ser His Ala Val Phe Asp Gly Phe Ser Leu Gly Val 
145                 150                 155                 160 


Phe Leu Ala Ala Trp Ser Lys Ala Thr Met Asn Pro Glu Arg Lys Ile 
                165                 170                 175     


Glu Ile Thr Pro Ser Phe Asp Leu Pro Ser Leu Leu Pro Tyr Lys Asp 
            180                 185                 190         


Glu Ser Phe Gly Leu Asn Phe Ser Glu Ile Val Lys Ala Glu Asn Ile 
        195                 200                 205             


Val Val Lys Arg Leu Asn Phe Gly Lys Glu Ala Ile Thr Arg Leu Arg 
    210                 215                 220                 


Ser Lys Leu Ser Pro Asn Gln Asn Gly Lys Thr Ile Ser Arg Val Arg 
225                 230                 235                 240 


Val Val Cys Ala Val Ile Val Lys Ala Leu Met Gly Leu Glu Arg Ala 
                245                 250                 255     


Lys Thr Arg Asp Phe Met Ile Cys Gln Gly Ile Asn Met Arg Glu Arg 
            260                 265                 270         


Thr Lys Ala Pro Leu Gln Lys His Ala Cys Gly Asn Leu Ala Val Ser 
        275                 280                 285             


Ser Tyr Thr Arg Arg Val Ala Ala Ala Glu Ala Glu Glu Leu Gln Ser 
    290                 295                 300                 


Leu Val Asn Leu Ile Gly Asp Ser Ile Glu Lys Ser Ile Ala Asp Tyr 
305                 310                 315                 320 


Ala Asp Ile Leu Ser Ser Asp Gln Asp Gly Arg His Ile Ile Ser Thr 
                325                 330                 335     


Met Met Lys Ser Phe Met Gln Phe Ala Ala Pro Asp Ile Lys Ala Ile 
            340                 345                 350         


Ser Phe Thr Asp Trp Ser Lys Phe Gly Phe Tyr Gln Val Asp Phe Gly 
        355                 360                 365             


Phe Gly Lys Pro Val Trp Thr Gly Val Arg Pro Glu Arg Pro Ile Phe 
    370                 375                 380                 


Ser Ala Ala Ile Leu Met Ser Asn Arg Glu Gly Asp Gly Ile Glu Ala 
385                 390                 395                 400 


Trp Leu His Leu Asp Lys Asn Asp Met Leu Ile Phe Glu Gln Asp Glu 
                405                 410                 415     


Glu Ile Lys Leu Leu Ile Thr Thr 
            420                 


<210>  27
<211>  1275
<212>  DNA
<213>  Coleus forskohlii

<400>  27
atgaaggttg aaagaataag caggaaattc ataaaaccat acaccccaac cccccaaaac       60

ctcaagaaat ataagctttc tcttttagac aaatgcatgg ggcacatgga ttttgctgtt      120

gttctgtttt atgaatcgaa accaagaaac aagaatgaat tggaagaatc actagaaaaa      180

gtcctggtcg atttctaccc tcttgctgga agatacacca tgaatgatca catagttgat      240

tgcagtgatg agggcgccgt gtttgtcgaa gccgaagctc caaacgtcga gctgacggtg      300

gatcaactcg tcaagaacat ggaggcccag actatccatg atttccttcc cgatcaatat      360

ttcccagctg atgctccaaa tccactcctc tcgatccagg tcacgcattt cccatgtggt      420

ggcttggcga ttggcatcgt tgtttctcac gctgtcttcg atggtttttc gctgggggtg      480

ttccttgccg cctggtcgaa ggccaccatg aacccagaga ggaagatcga aatcaccccg      540

tctttcgatc ttccttcgtt gcttccatac aaggatgaaa gtttcggatt aaatttcagc      600

gaaattgtca aggctgaaaa tattgttgtg aagaggctta atttcgggaa ggaggctata      660

acgaggttga gatcaaaact aagcccaaat caaaatggga aaacgatctc tcgcgttcga      720

gttgtttgcg ccgttatagt gaaagccttg atgggcctgg aacgcgccaa aacaagagat      780

ttcatgatct gtcaagggat caacatgcgt gagagaacaa aggcacctct acagaagcat      840

gcttgtggga atctggcggt ctcgtcttac acgcgacgtg tagccgcagc agaagccgag      900

gagctgcaga gtttggtaaa tctaataggt gattctattg agaagagcat agctgattat      960

gctgatattc tttcttctga tcaagatggg cgtcatatca tcagcacgat gatgaaatct     1020

ttcatgcaat tcgcggctcc tgacataaaa gctatatcct tcactgattg gagtaagttt     1080

ggattctacc aagttgattt tgggttcggg aagcctgttt ggacgggtgt tcggcccgaa     1140

cgcccaatct ttagcgccgc tattctcatg agcaacagag agggtgatgg aattgaggca     1200

tggcttcatc ttgacaaaaa tgacatgctt atcttcgagc aagatgaaga aatcaaatta     1260

ttaattacta cctaa                                                      1275


<210>  28
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  28
atgaaggtcg aaagaatctc cagaaagttc attaagccat acactccaac tccacaaaac       60

ttgaagaagt acaagttgtc cttgttggat aagtgcatgg gtcatatgga tttcgctgtt      120

gttttgttct acgaatccaa gccaagaaac aagaacgaat tggaagaatc cttggaaaag      180

gttttggttg acttttatcc attggctggt agatacacca tgaacgatca tatagttgat      240

tgctctgatg aaggtgccgt ttttgttgaa gctgaagctc caaatgttga attgaccgtt      300

gatcaattgg tcaagaacat ggaagctcaa accatccatg atttcttgcc agatcaatac      360

tttccagctg atgctcctaa tcctttgttg tctattcaag ttacccattt cccatgtggt      420

ggtttggcta ttggtatagt tgtttctcat gctgttttcg acggtttctc tttgggtgtt      480

tttttggctg cttggtctaa ggctactatg aatccagaaa gaaagatcga aatcacccca      540

tcttttgact tgccatcttt gttgccttac aaggatgaat ctttcggttt gaacttctcc      600

gaaatcgtta aggctgaaaa catcgttgtc aagagattga acttcggtaa agaagccatt      660

accagattga gatctaagtt gtccccaaat caaaacggta agaccatctc tagagttaga      720

gttgtttgtg ccgttattgt caaggctttg atgggtttgg aaagagctaa gactagagat      780

ttcatgatct gccaaggtat caacatgaga gaaagaacaa aagccccatt gcaaaaacat      840

gcttgtggta atttggccgt ttcttcatac actagaagag ttgctgctgc tgaagcagaa      900

gaattgcaat ctttggttaa cttgatcggt gactccatcg aaaagtctat tgctgattac      960

gccgatatct tgtcctctga tcaagatggt agacatatca tctccaccat gatgaagtct     1020

ttcatgcaat ttgctgcccc agatattaag gctatttctt tcactgactg gtccaagttt     1080

ggtttctacc aagttgattt tggtttcggt aaaccagttt ggactggtgt tagaccagaa     1140

agaccaattt tttccgctgc cattttgatg tctaacagag aaggtgatgg tattgaagct     1200

tggttgcatt tggataagaa cgacatgttg atcttcgaac aagacgaaga aatcaagttg     1260

ttgatcacca cctga                                                      1275


<210>  29
<211>  2169
<212>  DNA
<213>  Coleus forskohlii

<400>  29
atggcgtctt gtggagctat cgggagtagt ttcttgccac tgctccattc cgacgagtca       60

agcttgttat ctcggcccac tgctgctctt cacatcaaga agcagaagtt ttctgtggga      120

gctgctctgt accaggataa cacgaacgat gtcgttccga gtggagaggg tctgacgagg      180

cagaaaccaa gaactctgag tttcacggga gagaagcctt caactccaat tttggatacc      240

atcaactatc caatccacat gaagaatctg tccgtggagg aactggagat attggccgat      300

gaactgaggg aggagatagt ttacacggtg tcgaaaacgg gagggcattt gagctcaagc      360

ttgggtgtat cagagctcac cgttgcactg catcatgtat tcaacacacc cgatgacaaa      420

atcatctggg atgttggaca tcaggcgtat ccacacaaaa tcttgacagg gaggaggtcc      480

agaatgcaca ccatccgaca gactttcggg cttgcagggt tccccaagag ggatgagagc      540

ccgcacgacg cgttcggagc tggtcacagc tccactagta tttcagctgg tctagggatg      600

gcggtgggga gggacttgct acagaagaac aaccacgtga tctcggtgat cggagacgga      660

gccatgacag cggggcaggc atacgaggcc atgaacaatg caggatttct tgattccaat      720

ctgatcatcg tgttgaacga caacaaacaa gtgtccctgc ctacagccac cgtcgacggc      780

cctgctcctc ccgtcggagc cttgagcaaa gccctcacca agctgcaagc aagcaggaag      840

ttccggcagc tacgagaagc agcaaaaggc atgactaagc agatgggaaa ccaagcacac      900

gaaattgcat ccaaggtaga cacttacgtt aaaggaatga tggggaaacc aggcgcctcc      960

ctcttcgagg agctcgggat ttattacatc ggccctgtag atggacataa catcgaagat     1020

cttgtctata ttttcaagaa agttaaggag atgcctgcgc ccggccctgt tcttattcac     1080

atcatcaccg agaagggcaa aggctaccct ccagctgaag ttgctgctga caaaatgcat     1140

ggtgtggtga agtttgatcc aacaacgggg aaacagatga aggtgaaaac gaagactcaa     1200

tcatacaccc aatacttcgc ggagtctctg gttgcagaag cagagcagga cgagaaagtg     1260

gtggcgatcc acgcggcgat gggaggcgga acggggctga acatcttcca gaaacggttt     1320

cccgaccgat gtttcgatgt cgggatagcc gagcagcatg cagtcacctt cgccgcgggt     1380

cttgcaacgg aaggcctcaa gcccttctgc acaatctact cttccttcct gcagcgaggt     1440

tatgatcagg tggtgcacga tgtggatctt cagaaactcc cggtgagatt catgatggac     1500

agagctggac ttgtgggagc tgacggccca acccattgcg gcgccttcga caccacctac     1560

atggcctgcc tgcccaacat ggtcgtcatg gctccctccg atgaggctga gctcatgcac     1620

atggtcgcca ctgccgctgt cattgatgat cgccctagct gcgttaggta ccctagagga     1680

aacggtatag gggtgcccct ccctccaaac aataaaggaa ttccattaga ggttgggaag     1740

ggaaggattt tgaaagaggg taaccgagtt gccattctag gcttcggaac tatcgtgcaa     1800

aactgtctag cagcagccca acttcttcaa gaacacggca tatccgtgag cgtagccgat     1860

gcgagattct gcaagcctct ggatggagat ctgatcaaga atcttgtgaa ggagcacgaa     1920

gttctcatca ctgtggaaga gggatccatt ggaggattca gtgcacatgt ctctcatttc     1980

ttgtccctca atggactcct cgacggcaat cttaagtgga ggcctatggt gctcccagat     2040

aggtacattg atcatggagc ataccctgat cagattgagg aagcagggct gagctcaaag     2100

catattgcag gaactgtttt gtcacttatt ggtggaggga aagacagtct tcatttgatc     2160

aacatgtaa                                                             2169


<210>  30
<211>  722
<212>  PRT
<213>  Coleus forskohlii

<400>  30

Met Ala Ser Cys Gly Ala Ile Gly Ser Ser Phe Leu Pro Leu Leu His 
1               5                   10                  15      


Ser Asp Glu Ser Ser Leu Leu Ser Arg Pro Thr Ala Ala Leu His Ile 
            20                  25                  30          


Lys Lys Gln Lys Phe Ser Val Gly Ala Ala Leu Tyr Gln Asp Asn Thr 
        35                  40                  45              


Asn Asp Val Val Pro Ser Gly Glu Gly Leu Thr Arg Gln Lys Pro Arg 
    50                  55                  60                  


Thr Leu Ser Phe Thr Gly Glu Lys Pro Ser Thr Pro Ile Leu Asp Thr 
65                  70                  75                  80  


Ile Asn Tyr Pro Ile His Met Lys Asn Leu Ser Val Glu Glu Leu Glu 
                85                  90                  95      


Ile Leu Ala Asp Glu Leu Arg Glu Glu Ile Val Tyr Thr Val Ser Lys 
            100                 105                 110         


Thr Gly Gly His Leu Ser Ser Ser Leu Gly Val Ser Glu Leu Thr Val 
        115                 120                 125             


Ala Leu His His Val Phe Asn Thr Pro Asp Asp Lys Ile Ile Trp Asp 
    130                 135                 140                 


Val Gly His Gln Ala Tyr Pro His Lys Ile Leu Thr Gly Arg Arg Ser 
145                 150                 155                 160 


Arg Met His Thr Ile Arg Gln Thr Phe Gly Leu Ala Gly Phe Pro Lys 
                165                 170                 175     


Arg Asp Glu Ser Pro His Asp Ala Phe Gly Ala Gly His Ser Ser Thr 
            180                 185                 190         


Ser Ile Ser Ala Gly Leu Gly Met Ala Val Gly Arg Asp Leu Leu Gln 
        195                 200                 205             


Lys Asn Asn His Val Ile Ser Val Ile Gly Asp Gly Ala Met Thr Ala 
    210                 215                 220                 


Gly Gln Ala Tyr Glu Ala Met Asn Asn Ala Gly Phe Leu Asp Ser Asn 
225                 230                 235                 240 


Leu Ile Ile Val Leu Asn Asp Asn Lys Gln Val Ser Leu Pro Thr Ala 
                245                 250                 255     


Thr Val Asp Gly Pro Ala Pro Pro Val Gly Ala Leu Ser Lys Ala Leu 
            260                 265                 270         


Thr Lys Leu Gln Ala Ser Arg Lys Phe Arg Gln Leu Arg Glu Ala Ala 
        275                 280                 285             


Lys Gly Met Thr Lys Gln Met Gly Asn Gln Ala His Glu Ile Ala Ser 
    290                 295                 300                 


Lys Val Asp Thr Tyr Val Lys Gly Met Met Gly Lys Pro Gly Ala Ser 
305                 310                 315                 320 


Leu Phe Glu Glu Leu Gly Ile Tyr Tyr Ile Gly Pro Val Asp Gly His 
                325                 330                 335     


Asn Ile Glu Asp Leu Val Tyr Ile Phe Lys Lys Val Lys Glu Met Pro 
            340                 345                 350         


Ala Pro Gly Pro Val Leu Ile His Ile Ile Thr Glu Lys Gly Lys Gly 
        355                 360                 365             


Tyr Pro Pro Ala Glu Val Ala Ala Asp Lys Met His Gly Val Val Lys 
    370                 375                 380                 


Phe Asp Pro Thr Thr Gly Lys Gln Met Lys Val Lys Thr Lys Thr Gln 
385                 390                 395                 400 


Ser Tyr Thr Gln Tyr Phe Ala Glu Ser Leu Val Ala Glu Ala Glu Gln 
                405                 410                 415     


Asp Glu Lys Val Val Ala Ile His Ala Ala Met Gly Gly Gly Thr Gly 
            420                 425                 430         


Leu Asn Ile Phe Gln Lys Arg Phe Pro Asp Arg Cys Phe Asp Val Gly 
        435                 440                 445             


Ile Ala Glu Gln His Ala Val Thr Phe Ala Ala Gly Leu Ala Thr Glu 
    450                 455                 460                 


Gly Leu Lys Pro Phe Cys Thr Ile Tyr Ser Ser Phe Leu Gln Arg Gly 
465                 470                 475                 480 


Tyr Asp Gln Val Val His Asp Val Asp Leu Gln Lys Leu Pro Val Arg 
                485                 490                 495     


Phe Met Met Asp Arg Ala Gly Leu Val Gly Ala Asp Gly Pro Thr His 
            500                 505                 510         


Cys Gly Ala Phe Asp Thr Thr Tyr Met Ala Cys Leu Pro Asn Met Val 
        515                 520                 525             


Val Met Ala Pro Ser Asp Glu Ala Glu Leu Met His Met Val Ala Thr 
    530                 535                 540                 


Ala Ala Val Ile Asp Asp Arg Pro Ser Cys Val Arg Tyr Pro Arg Gly 
545                 550                 555                 560 


Asn Gly Ile Gly Val Pro Leu Pro Pro Asn Asn Lys Gly Ile Pro Leu 
                565                 570                 575     


Glu Val Gly Lys Gly Arg Ile Leu Lys Glu Gly Asn Arg Val Ala Ile 
            580                 585                 590         


Leu Gly Phe Gly Thr Ile Val Gln Asn Cys Leu Ala Ala Ala Gln Leu 
        595                 600                 605             


Leu Gln Glu His Gly Ile Ser Val Ser Val Ala Asp Ala Arg Phe Cys 
    610                 615                 620                 


Lys Pro Leu Asp Gly Asp Leu Ile Lys Asn Leu Val Lys Glu His Glu 
625                 630                 635                 640 


Val Leu Ile Thr Val Glu Glu Gly Ser Ile Gly Gly Phe Ser Ala His 
                645                 650                 655     


Val Ser His Phe Leu Ser Leu Asn Gly Leu Leu Asp Gly Asn Leu Lys 
            660                 665                 670         


Trp Arg Pro Met Val Leu Pro Asp Arg Tyr Ile Asp His Gly Ala Tyr 
        675                 680                 685             


Pro Asp Gln Ile Glu Glu Ala Gly Leu Ser Ser Lys His Ile Ala Gly 
    690                 695                 700                 


Thr Val Leu Ser Leu Ile Gly Gly Gly Lys Asp Ser Leu His Leu Ile 
705                 710                 715                 720 


Asn Met 
        


<210>  31
<211>  1083
<212>  DNA
<213>  Coleus forskohlii

<400>  31
atgaggtcta tgaatctggt cgatgcttgg gttcaaaacc tccccatttt caagcaacca       60

cacccctcca aattcatcca ccatcccaga ttcgagcccg ctttcctcaa atcgcggagg      120

cccatttcct ccttcgccgt ctccgccgtc ctcaccggcg aggaagcaag aatcttcacc      180

cgaggagatg aagcgccctt caatttcaac gcctacgtcg tcgagaaagc cacccacgtg      240

aacaaggctc tcgacgacgc ggtggcggtg aagaaccctc cgatgatcca cgaggccatg      300

aggtactcct tgctcgccgg cggaaagagg gtccgcccca tgctctgcat cgccgcctgc      360

gaggtggtgg gcggccccca agcggcggcg atccccgccg cctgcgcggt ggagatgatc      420

cacaccatgt ctctcatcca cgatgatctt ccctgtatgg acaatgatga cctccgccgc      480

ggcaagccca ccaatcacaa agtcttcggc gagaacgtcg ccgtgctcgc cggtgatgct      540

ttattggcct tcgcgtttga attcatcgcc actgccacca cgggggtggc ccctgagagg      600

attcttgcgg cggtggcgga gttggcgaag gcgatcggga cggaggggct ggtggcgggg      660

caggtggtgg atttgcattg caccggcaat cccaatgtag gactggacac attggaattc      720

atacacatac acaaaactgc agcattgctt gaggcctctg tagttttggg ggccattttg      780

ggaggaggaa gcagtgatca agttgagaaa ctgagaactt ttgctagaaa aattgggctt      840

ctcttccaag tggtggatga cattttagat gtcacaaaat cctcggagga gttggggaag      900

acggccggca aagacttggc cgtcgacaag accacctacc caaagcttct gggattggag      960

aaagctatgg agtttgctga gaggctgaat gaggaggcca agcagcagct gctggatttt     1020

gacccccgga aggcggcgcc gctggtggcg ctggccgatt acattgctca caggcagaac     1080

tag                                                                   1083


<210>  32
<211>  360
<212>  PRT
<213>  Coleus forskohlii

<400>  32

Met Arg Ser Met Asn Leu Val Asp Ala Trp Val Gln Asn Leu Pro Ile 
1               5                   10                  15      


Phe Lys Gln Pro His Pro Ser Lys Phe Ile His His Pro Arg Phe Glu 
            20                  25                  30          


Pro Ala Phe Leu Lys Ser Arg Arg Pro Ile Ser Ser Phe Ala Val Ser 
        35                  40                  45              


Ala Val Leu Thr Gly Glu Glu Ala Arg Ile Phe Thr Arg Gly Asp Glu 
    50                  55                  60                  


Ala Pro Phe Asn Phe Asn Ala Tyr Val Val Glu Lys Ala Thr His Val 
65                  70                  75                  80  


Asn Lys Ala Leu Asp Asp Ala Val Ala Val Lys Asn Pro Pro Met Ile 
                85                  90                  95      


His Glu Ala Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg 
            100                 105                 110         


Pro Met Leu Cys Ile Ala Ala Cys Glu Val Val Gly Gly Pro Gln Ala 
        115                 120                 125             


Ala Ala Ile Pro Ala Ala Cys Ala Val Glu Met Ile His Thr Met Ser 
    130                 135                 140                 


Leu Ile His Asp Asp Leu Pro Cys Met Asp Asn Asp Asp Leu Arg Arg 
145                 150                 155                 160 


Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asn Val Ala Val Leu 
                165                 170                 175     


Ala Gly Asp Ala Leu Leu Ala Phe Ala Phe Glu Phe Ile Ala Thr Ala 
            180                 185                 190         


Thr Thr Gly Val Ala Pro Glu Arg Ile Leu Ala Ala Val Ala Glu Leu 
        195                 200                 205             


Ala Lys Ala Ile Gly Thr Glu Gly Leu Val Ala Gly Gln Val Val Asp 
    210                 215                 220                 


Leu His Cys Thr Gly Asn Pro Asn Val Gly Leu Asp Thr Leu Glu Phe 
225                 230                 235                 240 


Ile His Ile His Lys Thr Ala Ala Leu Leu Glu Ala Ser Val Val Leu 
                245                 250                 255     


Gly Ala Ile Leu Gly Gly Gly Ser Ser Asp Gln Val Glu Lys Leu Arg 
            260                 265                 270         


Thr Phe Ala Arg Lys Ile Gly Leu Leu Phe Gln Val Val Asp Asp Ile 
        275                 280                 285             


Leu Asp Val Thr Lys Ser Ser Glu Glu Leu Gly Lys Thr Ala Gly Lys 
    290                 295                 300                 


Asp Leu Ala Val Asp Lys Thr Thr Tyr Pro Lys Leu Leu Gly Leu Glu 
305                 310                 315                 320 


Lys Ala Met Glu Phe Ala Glu Arg Leu Asn Glu Glu Ala Lys Gln Gln 
                325                 330                 335     


Leu Leu Asp Phe Asp Pro Arg Lys Ala Ala Pro Leu Val Ala Leu Ala 
            340                 345                 350         


Asp Tyr Ile Ala His Arg Gln Asn 
        355                 360 


<210>  33
<211>  2136
<212>  DNA
<213>  Coleus forskohlii

<400>  33
atggaatcga ctattgagaa gctttcgccc ttcgatttga tgactgcgat tctcaaagga       60

gtcaaacttg ataattcgaa cgggtctgct ggggtggagc atccggctgt gatcgcgatg      120

ctgatggaga acaaggatct cgtgatgatg ctcaccacct ccgtcgcggt gcttctagga      180

cttgctgtgt atctcgtgtg gcggcgcgga gccggatcgg cgaagagggt ggtggagccg      240

ccgaagctgg tgattcccaa gggcccggtg gatgcggagg aagaggatga tgggaagaag      300

aaggttacca tcttttttgg gacgcagact ggaactgctg aaggctttgc taaggcactt      360

gccgaagaag ctaaagcaag atatccgctg accaacttta aagtagttga cttggatgat      420

tatgctgccg atgatgaaga gtatgaagag aagatgaaga aggagacctt tgcattcttc      480

ttcttggcga catatggaga tggtgagcct accgacaatg ctgcgagatt ttacaagtgg      540

ttttccgagg ggaaagagag aggtgagata ttcaagaatc tcaactatgg tgtatttggt      600

cttggaaaca ggcagtatga gcatttcaac aagattgcta tagtggtgga tgacattctt      660

cttgagcaag gtggaaatcg gcttgtccct gtgggtcttg gagatgacga tcaatgtatc      720

gaagatgatt tctcagcatg gcgtgataat gtgtggcctg agctggataa gttgctccgt      780

gatgaggatg atgcaactgt tgcaactcca tatactgcag ccgttttgga gtatcgtgtt      840

gtgttccatg accagtcaga tgaactgcac tcggaaaaca acttagccaa tggtcatgca      900

aatggaaatg cttcttatga tgctcaacac ccctgcaaag tgaatgttgc tgtaaaaagg      960

gagctacata ctcctctatc cgatcgttct tgcactcact tggaattcga catatctggc     1020

actggattag agtatgaaac aggggaccac gttggtgttt actgtgagaa cttgattgaa     1080

actgtagagg aagcagaaag gcttcttggt ctttctccac aaacattctt ttcagttcac     1140

actgataaag cggacggcac accacttggt ggaagtgcct tgcctcctcc cttcccgccg     1200

tgcactttga ggacagcgct aagtcgatat gctgatcttt tgaatgctcc caaaaagtct     1260

gctttgactg cattggctgc ttatgcctct gaccctagtg aagctgatcg gctcaagcac     1320

cttgcttccc ctgatggaaa ggaggaatat gctcaatatg tggtttctgg tcagagaagc     1380

ctacttgagg tgatggctga cttcccatct gccaagcctc ctcttggtgt tttctttgct     1440

gcaattgctc ctcgcttgca gcctcgattt tattcaatct catcctcacc aaagattgca     1500

ccttcaagaa ttcacgtcac ttgtgcgttg gtgtatgaga aaatgcccac tggacgaatc     1560

cacaagggtg tctgctcaac atggatgaag aatgctgtgc cattggagga aagccccaac     1620

tgctcttcag caccagtttt tgtacggacc tcaaacttca gactccctgc tgatcctaaa     1680

gtaccagtta taatgattgg ccctggaacc ggtttggctc cattcagggg ttttcttcag     1740

gaaagattag ccctcaagga atctggagca gaacttggtc ctgctatatt attcttcggg     1800

tgcagaaaca gtaaaatgga tttcatttac caagatgaac tggataactt tgttaaagct     1860

ggagtggttt ctgagcttgt ccttgcgttt tcacgcgagg gtcctgctaa ggaatacgtg     1920

cagcataaga tggcacagaa ggcctcggat gtgtggaata tgatatcaga agggggctac     1980

gtttatgtat gtggtgatgc taagggcatg gcacgtgacg ttcaccggac tcttcacacc     2040

attgttcaag aacagggatc tctggacagc tcgaaaaccg agagcttcgt caagaatctg     2100

cagatgaccg gccggtacct gcgtgacgtg tggtga                               2136


<210>  34
<211>  711
<212>  PRT
<213>  Coleus forskohlii

<400>  34

Met Glu Ser Thr Ile Glu Lys Leu Ser Pro Phe Asp Leu Met Thr Ala 
1               5                   10                  15      


Ile Leu Lys Gly Val Lys Leu Asp Asn Ser Asn Gly Ser Ala Gly Val 
            20                  25                  30          


Glu His Pro Ala Val Ile Ala Met Leu Met Glu Asn Lys Asp Leu Val 
        35                  40                  45              


Met Met Leu Thr Thr Ser Val Ala Val Leu Leu Gly Leu Ala Val Tyr 
    50                  55                  60                  


Leu Val Trp Arg Arg Gly Ala Gly Ser Ala Lys Arg Val Val Glu Pro 
65                  70                  75                  80  


Pro Lys Leu Val Ile Pro Lys Gly Pro Val Asp Ala Glu Glu Glu Asp 
                85                  90                  95      


Asp Gly Lys Lys Lys Val Thr Ile Phe Phe Gly Thr Gln Thr Gly Thr 
            100                 105                 110         


Ala Glu Gly Phe Ala Lys Ala Leu Ala Glu Glu Ala Lys Ala Arg Tyr 
        115                 120                 125             


Pro Leu Thr Asn Phe Lys Val Val Asp Leu Asp Asp Tyr Ala Ala Asp 
    130                 135                 140                 


Asp Glu Glu Tyr Glu Glu Lys Met Lys Lys Glu Thr Phe Ala Phe Phe 
145                 150                 155                 160 


Phe Leu Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg 
                165                 170                 175     


Phe Tyr Lys Trp Phe Ser Glu Gly Lys Glu Arg Gly Glu Ile Phe Lys 
            180                 185                 190         


Asn Leu Asn Tyr Gly Val Phe Gly Leu Gly Asn Arg Gln Tyr Glu His 
        195                 200                 205             


Phe Asn Lys Ile Ala Ile Val Val Asp Asp Ile Leu Leu Glu Gln Gly 
    210                 215                 220                 


Gly Asn Arg Leu Val Pro Val Gly Leu Gly Asp Asp Asp Gln Cys Ile 
225                 230                 235                 240 


Glu Asp Asp Phe Ser Ala Trp Arg Asp Asn Val Trp Pro Glu Leu Asp 
                245                 250                 255     


Lys Leu Leu Arg Asp Glu Asp Asp Ala Thr Val Ala Thr Pro Tyr Thr 
            260                 265                 270         


Ala Ala Val Leu Glu Tyr Arg Val Val Phe His Asp Gln Ser Asp Glu 
        275                 280                 285             


Leu His Ser Glu Asn Asn Leu Ala Asn Gly His Ala Asn Gly Asn Ala 
    290                 295                 300                 


Ser Tyr Asp Ala Gln His Pro Cys Lys Val Asn Val Ala Val Lys Arg 
305                 310                 315                 320 


Glu Leu His Thr Pro Leu Ser Asp Arg Ser Cys Thr His Leu Glu Phe 
                325                 330                 335     


Asp Ile Ser Gly Thr Gly Leu Glu Tyr Glu Thr Gly Asp His Val Gly 
            340                 345                 350         


Val Tyr Cys Glu Asn Leu Ile Glu Thr Val Glu Glu Ala Glu Arg Leu 
        355                 360                 365             


Leu Gly Leu Ser Pro Gln Thr Phe Phe Ser Val His Thr Asp Lys Ala 
    370                 375                 380                 


Asp Gly Thr Pro Leu Gly Gly Ser Ala Leu Pro Pro Pro Phe Pro Pro 
385                 390                 395                 400 


Cys Thr Leu Arg Thr Ala Leu Ser Arg Tyr Ala Asp Leu Leu Asn Ala 
                405                 410                 415     


Pro Lys Lys Ser Ala Leu Thr Ala Leu Ala Ala Tyr Ala Ser Asp Pro 
            420                 425                 430         


Ser Glu Ala Asp Arg Leu Lys His Leu Ala Ser Pro Asp Gly Lys Glu 
        435                 440                 445             


Glu Tyr Ala Gln Tyr Val Val Ser Gly Gln Arg Ser Leu Leu Glu Val 
    450                 455                 460                 


Met Ala Asp Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala 
465                 470                 475                 480 


Ala Ile Ala Pro Arg Leu Gln Pro Arg Phe Tyr Ser Ile Ser Ser Ser 
                485                 490                 495     


Pro Lys Ile Ala Pro Ser Arg Ile His Val Thr Cys Ala Leu Val Tyr 
            500                 505                 510         


Glu Lys Met Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp 
        515                 520                 525             


Met Lys Asn Ala Val Pro Leu Glu Glu Ser Pro Asn Cys Ser Ser Ala 
    530                 535                 540                 


Pro Val Phe Val Arg Thr Ser Asn Phe Arg Leu Pro Ala Asp Pro Lys 
545                 550                 555                 560 


Val Pro Val Ile Met Ile Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg 
                565                 570                 575     


Gly Phe Leu Gln Glu Arg Leu Ala Leu Lys Glu Ser Gly Ala Glu Leu 
            580                 585                 590         


Gly Pro Ala Ile Leu Phe Phe Gly Cys Arg Asn Ser Lys Met Asp Phe 
        595                 600                 605             


Ile Tyr Gln Asp Glu Leu Asp Asn Phe Val Lys Ala Gly Val Val Ser 
    610                 615                 620                 


Glu Leu Val Leu Ala Phe Ser Arg Glu Gly Pro Ala Lys Glu Tyr Val 
625                 630                 635                 640 


Gln His Lys Met Ala Gln Lys Ala Ser Asp Val Trp Asn Met Ile Ser 
                645                 650                 655     


Glu Gly Gly Tyr Val Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Arg 
            660                 665                 670         


Asp Val His Arg Thr Leu His Thr Ile Val Gln Glu Gln Gly Ser Leu 
        675                 680                 685             


Asp Ser Ser Lys Thr Glu Ser Phe Val Lys Asn Leu Gln Met Thr Gly 
    690                 695                 700                 


Arg Tyr Leu Arg Asp Val Trp 
705                 710     


<210>  35
<211>  2196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  35
atgtccagag ttgcttcctt ggatgctttg aatggtattc aaaaagttgg tccagctacc       60

attggtactc cagaagaaga aaacaagaag atcgaagatt ccatcgaata cgtcaaagaa      120

ttattgaaaa ccatgggtga cggtagaatc tctgtttctc catatgatac tgctatcgtc      180

gccttgatta aggatttgga aggtggtgat ggtccagaat ttccatcttg tttggaatgg      240

attgcccaaa atcaattggc tgatggttct tggggtgatc attttttctg tatctacgat      300

agagttgtta acaccgctgc ttgtgttgtt gctttgaaat cttggaatgt tcacgccgat      360

aagattgaaa aaggtgccgt ttacttgaaa gaaaacgtcc acaaattgaa ggacggtaag      420

atagaacata tgccagctgg ttttgaattc gttgttccag caactttgga aagagctaaa      480

gctttgggta ttaagggttt gccatatgat gatccattca tcagagaaat ctactccgct      540

aagcaaacta gattgactaa gattccaaag ggtatgatct acgaatctcc aacctctttg      600

ttgtactctt tggatggttt agaaggtttg gaatgggata agatcttgaa gttgcaatca      660

gctgacggtt ctttcatcac ttctgtttct tctactgcct tcgttttcat gcataccaac      720

gatttgaagt gccatgcctt tattaagaac gctttgacta actgtaatgg tggtgttcca      780

catacttacc cagttgatat ttttgctaga ttgtgggccg ttgacagatt gcaaagattg      840

ggtatttcta gattcttcga accagaaatc aaatacttga tggaccacat caacaacgtt      900

tggagagaaa agggtgtttt ctcatccaga cattctcaat tcgccgatat tgatgatacc      960

tccatgggta tcagattatt gaagatgcat ggttacaacg ttaacccaaa cgctttggaa     1020

catttcaagc aaaaggatgg taaattcacc tgttacgccg atcaacatat tgaatctcca     1080

tctccaatgt ataacttgta cagagctgcc caattgagat ttccaggtga agaaatttta     1140

caacaagcct tgcaattcgc ctacaacttc ttgcacgaaa atttggcttc taaccacttc     1200

caagaaaagt gggttatctc cgatcatttg atcgatgaag ttagaatcgg tttgaaaatg     1260

ccatggtatg ctactttgcc aagagttgaa gcttcttact acttgcaaca ttacggtggt     1320

tcttccgatg tttggattgg taaaaccttg tatagaatgc cagaaatctc taacgacacc     1380

tacaagattt tggctcaatt ggatttcaac aagtgccaag ctcaacatca attagaatgg     1440

atgtctatga aggaatggta tcaatccaac aacgtaaaag aattcggtat ctccaagaaa     1500

gaattgttgt tggcttactt tttggctgct gctactatgt ttgaacctga aagaactcaa     1560

gaaagaatca tgtgggctaa gacccaagtt gtttctagaa tgattacctc attcttgaac     1620

aaagaaaaca ctatgtcctt cgacttgaag attgctttgt tgactcaacc acaacaccaa     1680

atcaatggtt ccgaaatgaa gaatggtttg gcacaaactt taccagctgc cttcagacaa     1740

ttattgaaag aattcgacaa gtacaccaga caccaattga gaaatacttg gaacaagtgg     1800

ttgatgaagt tgaagcaagg tgatgataac ggtggtgctg atgctgaatt attggctaac     1860

actttgaaca tttgcgccgg tcataacgaa gatattttgt cccattacga atacaccgcc     1920

ttgtcatctt tgaccaacaa gatttgtcaa agattgtccc aaatccaaga taagaagatg     1980

ttggaaatcg aagaaggttc catcaaggac aaagaaatgg aattggaaat tcaaaccttg     2040

gtcaagttgg tattgcaaga aacttctggt ggtatcgaca gaaacatcaa gcaaactttc     2100

ttgtccgttt tcaagacctt ctactacaga gcttaccatg atgctaagac cattgatgcc     2160

catatcttcc aagttttgtt cgaacctgtt gtttaa                               2196


<210>  36
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  36
atgatcacct ccaaatcttc cgctgctgtt aagtgttctt tgactactcc aactgatttg       60

atgggtaaga tcaaagaagt tttcaacaga gaagttgata cctctccagc tgctatgact      120

actcattcta ctgatattcc atccaacttg tgcatcatcg ataccttgca aagattgggt      180

atcgaccaat acttccaatc cgaaattgat gctgtcttgc atgatactta cagattgtgg      240

caattgaaga agaaggacat cttctctgat attaccactc atgctatggc cttcagatta      300

ttgagagtta agggttacga agttgcctct gatgaattgg ctccatatgc tgatcaagaa      360

agaatcaact tgcaaaccat tgatgttcca accgtcgtcg aattatacag agctgcacaa      420

gaaagattga ccgaagaaga ttctaccttg gaaaagttgt acgtttggac ttctgctttc      480

ttgaagcaac aattattgac cgatgccatc ccagataaga agttgcataa gcaagtcgaa      540

tattacttga agaactacca cggtatcttg gatagaatgg gtgttagaag aaacttggac      600

ttgtacgata tctcccacta caaatctttg aaggctgctc atagattcta caacttgtct      660

aacgaagata ttttggcctt cgccagacaa gatttcaaca tttctcaagc ccaacaccaa      720

aaagaattgc aacaattgca aagatggtac gccgattgca gattggatac tttgaaattc      780

ggtagagatg tcgtcagaat cggtaacttt ttaacctctg ctatgatcgg tgatccagaa      840

ttgtctgatt tgagattggc ttttgctaag cacatcgttt tggttaccag aatcgatgat      900

ttcttcgatc atggtggtcc aaaagaagaa tcctacgaaa ttttggaatt ggtcaaagaa      960

tggaaagaaa agccagctgg tgaatacgtt tctgaagaag tcgaaatctt attcaccgct     1020

gtttacaaca ccgttaacga attggctgaa atggcccata ttgaacaagg tagatctgtt     1080

aaggatttgt tggttaagtt gtgggtcgaa atattgtccg ttttcagaat cgaattggat     1140

acctggacta acgatactgc tttgactttg gaagaatact tgtcccaatc ctgggtttct     1200

attggttgca gaatctgcat tttgatctcc atgcaattcc aaggtgttaa gttgagtgac     1260

gaaatgttgc aaagtgaaga atgtaccgat ttgtgcagat acgtttccat ggtcgataga     1320

ttattgaacg atgtccaaac cttcgaaaaa gaaagaaaag aaaacaccgg taactccgtt     1380

tctttgttgc aagctgctca caaagacgaa agagttatca acgaagaaga agcctgcatc     1440

aaggtaaaag aattagccga atacaataga agaaagttga tgcaaatcgt ctacaagacc     1500

ggtactattt tcccaagaaa atgcaaggac ttgttcttga aggcttgtag aattggttgc     1560

tacttgtact cttctggtga tgaattcact tccccacaac aaatgatgga agatatgaag     1620

tccttggtct atgaaccatt gccaatttct ccacctgaag ctaacaatgc atctggtgaa     1680

aaaatgtcct gcgtcagtaa ctga                                            1704


<210>  37
<211>  297
<212>  PRT
<213>  Synechococcus sp.

<400>  37

Met Val Ala Gln Thr Phe Asn Leu Asp Thr Tyr Leu Ser Gln Arg Gln 
1               5                   10                  15      


Gln Gln Val Glu Glu Ala Leu Ser Ala Ala Leu Val Pro Ala Tyr Pro 
            20                  25                  30          


Glu Arg Ile Tyr Glu Ala Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys 
        35                  40                  45              


Arg Leu Arg Pro Ile Leu Cys Leu Ala Ala Cys Glu Leu Ala Gly Gly 
    50                  55                  60                  


Ser Val Glu Gln Ala Met Pro Thr Ala Cys Ala Leu Glu Met Ile His 
65                  70                  75                  80  


Thr Met Ser Leu Ile His Asp Asp Leu Pro Ala Met Asp Asn Asp Asp 
                85                  90                  95      


Phe Arg Arg Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Ile 
            100                 105                 110         


Ala Ile Leu Ala Gly Asp Ala Leu Leu Ala Tyr Ala Phe Glu His Ile 
        115                 120                 125             


Ala Ser Gln Thr Arg Gly Val Pro Pro Gln Leu Val Leu Gln Val Ile 
    130                 135                 140                 


Ala Arg Ile Gly His Ala Val Ala Ala Thr Gly Leu Val Gly Gly Gln 
145                 150                 155                 160 


Val Val Asp Leu Glu Ser Glu Gly Lys Ala Ile Ser Leu Glu Thr Leu 
                165                 170                 175     


Glu Tyr Ile His Ser His Lys Thr Gly Ala Leu Leu Glu Ala Ser Val 
            180                 185                 190         


Val Ser Gly Gly Ile Leu Ala Gly Ala Asp Glu Glu Leu Leu Ala Arg 
        195                 200                 205             


Leu Ser His Tyr Ala Arg Asp Ile Gly Leu Ala Phe Gln Ile Val Asp 
    210                 215                 220                 


Asp Ile Leu Asp Val Thr Ala Thr Ser Glu Gln Leu Gly Lys Thr Ala 
225                 230                 235                 240 


Gly Lys Asp Gln Ala Ala Ala Lys Ala Thr Tyr Pro Ser Leu Leu Gly 
                245                 250                 255     


Leu Glu Ala Ser Arg Gln Lys Ala Glu Glu Leu Ile Gln Ser Ala Lys 
            260                 265                 270         


Glu Ala Leu Arg Pro Tyr Gly Ser Gln Ala Glu Pro Leu Leu Ala Leu 
        275                 280                 285             


Ala Asp Phe Ile Thr Arg Arg Gln His 
    290                 295         


<210>  38
<211>  894
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequence codon optimised for expression in S. cerevisiae

<400>  38
atggtcgcac aaactttcaa cctggatacc tacttatccc aaagacaaca acaagttgaa       60

gaggccctaa gtgctgctct tgtgccagct tatcctgaga gaatatacga agctatgaga      120

tactccctcc tggcaggtgg caaaagatta agacctatct tatgtttagc tgcttgcgaa      180

ttggcaggtg gttctgttga acaagccatg ccaactgcgt gtgcacttga aatgatccat      240

acaatgtcac taattcatga tgacctgcca gccatggata acgatgattt cagaagagga      300

aagccaacta atcacaaggt gttcggggaa gatatagcca tcttagcggg tgatgcgctt      360

ttagcttacg cttttgaaca tattgcttct caaacaagag gagtaccacc tcaattggtg      420

ctacaagtta ttgctagaat cggacacgcc gttgctgcaa caggcctcgt tggaggccaa      480

gtcgtagacc ttgaatctga aggtaaagct atttccttag aaacattgga gtatattcac      540

tcacataaga ctggagcctt gctggaagca tcagttgtct caggcggtat tctcgcaggg      600

gcagatgaag agcttttggc cagattgtct cattacgcta gagatatagg cttggctttt      660

caaatcgtcg atgatatcct ggatgttact gctacatctg aacagttggg gaaaaccgct      720

ggtaaagacc aggcagccgc aaaggcaact tatccaagtc tattgggttt agaagcctct      780

agacagaaag cggaagagtt gattcaatct gctaaggaag ccttaagacc ttacggttca      840

caagcagagc cactcctagc gctggcagac ttcatcacac gtcgtcagca ttaa            894


