                         SEQUENCE LISTING

<110>  ACADEMIA SINICA
 
<120>  ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED 
       CANCER THERAPY

<130>  10011-051PCT

<150>  62147344
<151>  2015-04-14

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH CDR1

<400>  1

Gly Phe Thr Phe Ser Ser Tyr Ser 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH CDR2

<400>  2

Ile Ser Ser Ser Ser Ser Tyr Ile 
1               5               


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH CDR3

<400>  3

Ala Arg Ser Thr Asp Ala Phe Asp Ile 
1               5                   


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VL CDR1

<400>  4

Gln Arg Ile Ser Asn Tyr 
1               5       


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 V L CDR3

<400>  5

Gln Gln Tyr Asp Arg Tyr Pro Pro Thr 
1               5                   


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VH CDR1

<400>  6

Gly Phe Thr Phe Gly Ser Tyr Thr 
1               5               


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12VH CDR2

<400>  7

Ile Thr Ser Gly Ser Ser Tyr Ile 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VH CDR3

<400>  8

Ala Arg Gly Ser Ala Ser Ala Phe Asp Ile 
1               5                   10  


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VL CDR1

<400>  9

Asp Asp Ile Ile Asn Tyr 
1               5       


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 V L CDR3

<400>  10

Gln Gln Tyr Asp Ile Leu Pro Leu Thr 
1               5                   


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH CDR1

<400>  11

Glu Phe Thr Phe Ser His Tyr Asn 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH CDR2

<400>  12

Ile Ser Asp Asp Gly Arg Asn Lys 
1               5               


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH CDR3

<400>  13

Ala Arg Val Pro Thr Val Trp Arg Gly Gly Val Tyr Asp Ile 
1               5                   10                  


<210>  14
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VL CDR1

<400>  14

Gln Ser Val Gly Ser Tyr 
1               5       


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 V L CDR3

<400>  15

His Gln Ser Ser Ser Leu Pro Arg Thr 
1               5                   


<210>  16
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH CDR1

<400>  16

Gly Gly Asn Phe Ile Ser Lys Gly 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH CDR2

<400>  17

Ile Ile Pro Leu Phe Gly Thr Gly 
1               5               


<210>  18
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH CDR3

<400>  18

Ala Thr Ala Asp Val Asp Tyr Ser Asp Ser Leu Glu Ala Phe Asp Met 
1               5                   10                  15      


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VL CDR1

<400>  19

Gln Ser Ile Asn Asn Tyr 
1               5       


<210>  20
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 V L CDR3

<400>  20

Gln Gln Ser Tyr Ser Thr Pro Leu 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH CDR1

<400>  21

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH CDR2

<400>  22

Ile Ser Tyr Asp Gly Ser Asn Lys 
1               5               


<210>  23
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH CDR3

<400>  23

Ala Arg Glu Gln Asp Tyr Gly Ser Ser Ser Gly Asp Ala Phe Asp Ile 
1               5                   10                  15      


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VL CDR1

<400>  24

Gln Arg Ile Ser Ser Tyr 
1               5       


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 V L CDR3

<400>  25

His Gln Ser Tyr Ser Ala Pro Pro Thr 
1               5                   


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH FR1

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  27
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH FR2

<400>  27

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Ser 
    


<210>  28
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH FR3

<400>  28

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  29
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VH FR4

<400>  29

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  30
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VL FR1

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VL FR2

<400>  31

Leu Asn Trp Tyr Gln His Lys Ser Gly Glu Asp Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  32
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VL FR3

<400>  32

Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC8 VL FR4

<400>  33

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  34
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VH FR1

<400>  34

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VH FR2

<400>  35

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Ser 
    


<210>  36
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VH FR3

<400>  36

Phe Tyr Thr Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Arg Ser Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VH FR4

<400>  37

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  38
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VL FR1

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  39
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VL FR2

<400>  39

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  40
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VL FR3

<400>  40

Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC12 VL FR4

<400>  41

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  42
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH FR1

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser 
            20                  25  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH FR2

<400>  43

Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Ala 
1               5                   10                  15      


Val 
    


<210>  44
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH FR3

<400>  44

Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Gly Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  45
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VH FR4

<400>  45

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  46
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VL FR1

<400>  46

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
            20                  25      


<210>  47
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VL FR2

<400>  47

Leu Ala Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro Arg Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  48
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VL FR3

<400>  48

Asn Arg Ala Thr Gly Val Ala Ala Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asp Ser Leu Glu Ala Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC28 VL FR4

<400>  49

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  50
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH FR1

<400>  50

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Met Lys Lys Ser Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser 
            20                  25  


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH FR2

<400>  51

Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  15      


Gly 
    


<210>  52
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH FR3

<400>  52

Asn Tyr Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu 
1               5                   10                  15      


Ser Thr Thr Thr Val Tyr Leu Gln Leu Thr Ser Leu Thr Pro Glu Asp 
            20                  25                  30          


Thr Ala Met Tyr Phe Cys 
        35              


<210>  53
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VH FR4

<400>  53

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  54
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VL FR1

<400>  54

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VL FR2

<400>  55

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  56
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VL FR3

<400>  56

Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Arg Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC29 VL FR4

<400>  57

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  58
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH FR1

<400>  58

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  59
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH FR2

<400>  59

Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Val 
    


<210>  60
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH FR3

<400>  60

Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VH FR4

<400>  61

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  62
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VL FR1

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VL FR2

<400>  63

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  64
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VL FR3

<400>  64

Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Gln Pro Asp Asp Phe Ala 
            20                  25                  30          


Ile Tyr Phe Cys 
        35      


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2PC45 VL FR4

<400>  65

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  66
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  66

Asn Trp Glu Tyr Pro Ser 
1               5       


<210>  67
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  67

Thr Gln Ser Gly Ser Glu Met 
1               5           


<210>  68
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  68

Thr Trp His Ser Pro Pro 
1               5       


<210>  69
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  69

Pro Phe Pro Gly Thr Val Ala 
1               5           


<210>  70
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-VEGFR2 shRNA sequence

<400>  70
ccggcgctga catgtacggt ctatgctcga gcatagaccg tacatgtcag cgttttttg        59


<210>  71
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFR2-F primer

<400>  71
gaacatttgg gaaatctctt gc                                                22


<210>  72
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VEGFR2-R primer

<400>  72
cggaagaaca atgtagtctt tgc                                               23


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R2S12AF variable light chain CDR3

<400>  73

Gln Gln Leu Asp Asp Ile Pro Ile Thr 
1               5                   


<210>  74
<211>  1356
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Gln Ser Lys Val Leu Leu Ala Val Ala Leu Trp Leu Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Ser Val Ser Leu Asp Leu Pro 
            20                  25                  30          


Arg Leu Ser Ile Gln Lys Asp Ile Leu Thr Ile Lys Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Asn Gln Ser Gly Ser Glu Gln Arg Val Glu Val Thr Glu Cys Ser 
65                  70                  75                  80  


Asp Gly Leu Phe Cys Lys Thr Leu Thr Ile Pro Lys Val Ile Gly Asn 
                85                  90                  95      


Asp Thr Gly Ala Tyr Lys Cys Phe Tyr Arg Glu Thr Asp Leu Ala Ser 
            100                 105                 110         


Val Ile Tyr Val Tyr Val Gln Asp Tyr Arg Ser Pro Phe Ile Ala Ser 
        115                 120                 125             


Val Ser Asp Gln His Gly Val Val Tyr Ile Thr Glu Asn Lys Asn Lys 
    130                 135                 140                 


Thr Val Val Ile Pro Cys Leu Gly Ser Ile Ser Asn Leu Asn Val Ser 
145                 150                 155                 160 


Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly Asn Arg 
                165                 170                 175     


Ile Ser Trp Asp Ser Lys Lys Gly Phe Thr Ile Pro Ser Tyr Met Ile 
            180                 185                 190         


Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp Glu Ser 
        195                 200                 205             


Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Tyr Arg Ile Tyr 
    210                 215                 220                 


Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu 
225                 230                 235                 240 


Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile 
                245                 250                 255     


Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu 
            260                 265                 270         


Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe 
        275                 280                 285             


Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu 
    290                 295                 300                 


Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr 
305                 310                 315                 320 


Phe Val Arg Val His Glu Lys Pro Phe Val Ala Phe Gly Ser Gly Met 
                325                 330                 335     


Glu Ser Leu Val Glu Ala Thr Val Gly Glu Arg Val Arg Ile Pro Ala 
            340                 345                 350         


Lys Tyr Leu Gly Tyr Pro Pro Pro Glu Ile Lys Trp Tyr Lys Asn Gly 
        355                 360                 365             


Ile Pro Leu Glu Ser Asn His Thr Ile Lys Ala Gly His Val Leu Thr 
    370                 375                 380                 


Ile Met Glu Val Ser Glu Arg Asp Thr Gly Asn Tyr Thr Val Ile Leu 
385                 390                 395                 400 


Thr Asn Pro Ile Ser Lys Glu Lys Gln Ser His Val Val Ser Leu Val 
                405                 410                 415     


Val Tyr Val Pro Pro Gln Ile Gly Glu Lys Ser Leu Ile Ser Pro Val 
            420                 425                 430         


Asp Ser Tyr Gln Tyr Gly Thr Thr Gln Thr Leu Thr Cys Thr Val Tyr 
        435                 440                 445             


Ala Ile Pro Pro Pro His His Ile His Trp Tyr Trp Gln Leu Glu Glu 
    450                 455                 460                 


Glu Cys Ala Asn Glu Pro Ser Gln Ala Val Ser Val Thr Asn Pro Tyr 
465                 470                 475                 480 


Pro Cys Glu Glu Trp Arg Ser Val Glu Asp Phe Gln Gly Gly Asn Lys 
                485                 490                 495     


Ile Glu Val Asn Lys Asn Gln Phe Ala Leu Ile Glu Gly Lys Asn Lys 
            500                 505                 510         


Thr Val Ser Thr Leu Val Ile Gln Ala Ala Asn Val Ser Ala Leu Tyr 
        515                 520                 525             


Lys Cys Glu Ala Val Asn Lys Val Gly Arg Gly Glu Arg Val Ile Ser 
    530                 535                 540                 


Phe His Val Thr Arg Gly Pro Glu Ile Thr Leu Gln Pro Asp Met Gln 
545                 550                 555                 560 


Pro Thr Glu Gln Glu Ser Val Ser Leu Trp Cys Thr Ala Asp Arg Ser 
                565                 570                 575     


Thr Phe Glu Asn Leu Thr Trp Tyr Lys Leu Gly Pro Gln Pro Leu Pro 
            580                 585                 590         


Ile His Val Gly Glu Leu Pro Thr Pro Val Cys Lys Asn Leu Asp Thr 
        595                 600                 605             


Leu Trp Lys Leu Asn Ala Thr Met Phe Ser Asn Ser Thr Asn Asp Ile 
    610                 615                 620                 


Leu Ile Met Glu Leu Lys Asn Ala Ser Leu Gln Asp Gln Gly Asp Tyr 
625                 630                 635                 640 


Val Cys Leu Ala Gln Asp Arg Lys Thr Lys Lys Arg His Cys Val Val 
                645                 650                 655     


Arg Gln Leu Thr Val Leu Glu Arg Val Ala Pro Thr Ile Thr Gly Asn 
            660                 665                 670         


Leu Glu Asn Gln Thr Thr Ser Ile Gly Glu Ser Ile Glu Val Ser Cys 
        675                 680                 685             


Thr Ala Ser Gly Asn Pro Pro Pro Gln Ile Met Trp Phe Lys Asp Asn 
    690                 695                 700                 


Glu Thr Leu Val Glu Asp Ser Gly Ile Val Leu Lys Asp Gly Asn Arg 
705                 710                 715                 720 


Asn Leu Thr Ile Arg Arg Val Arg Lys Glu Asp Glu Gly Leu Tyr Thr 
                725                 730                 735     


Cys Gln Ala Cys Ser Val Leu Gly Cys Ala Lys Val Glu Ala Phe Phe 
            740                 745                 750         


Ile Ile Glu Gly Ala Gln Glu Lys Thr Asn Leu Glu Ile Ile Ile Leu 
        755                 760                 765             


Val Gly Thr Ala Val Ile Ala Met Phe Phe Trp Leu Leu Leu Val Ile 
    770                 775                 780                 


Ile Leu Arg Thr Val Lys Arg Ala Asn Gly Gly Glu Leu Lys Thr Gly 
785                 790                 795                 800 


Tyr Leu Ser Ile Val Met Asp Pro Asp Glu Leu Pro Leu Asp Glu His 
                805                 810                 815     


Cys Glu Arg Leu Pro Tyr Asp Ala Ser Lys Trp Glu Phe Pro Arg Asp 
            820                 825                 830         


Arg Leu Lys Leu Gly Lys Pro Leu Gly Arg Gly Ala Phe Gly Gln Val 
        835                 840                 845             


Ile Glu Ala Asp Ala Phe Gly Ile Asp Lys Thr Ala Thr Cys Arg Thr 
    850                 855                 860                 


Val Ala Val Lys Met Leu Lys Glu Gly Ala Thr His Ser Glu His Arg 
865                 870                 875                 880 


Ala Leu Met Ser Glu Leu Lys Ile Leu Ile His Ile Gly His His Leu 
                885                 890                 895     


Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys Pro Gly Gly Pro Leu 
            900                 905                 910         


Met Val Ile Val Glu Phe Cys Lys Phe Gly Asn Leu Ser Thr Tyr Leu 
        915                 920                 925             


Arg Ser Lys Arg Asn Glu Phe Val Pro Tyr Lys Thr Lys Gly Ala Arg 
    930                 935                 940                 


Phe Arg Gln Gly Lys Asp Tyr Val Gly Ala Ile Pro Val Asp Leu Lys 
945                 950                 955                 960 


Arg Arg Leu Asp Ser Ile Thr Ser Ser Gln Ser Ser Ala Ser Ser Gly 
                965                 970                 975     


Phe Val Glu Glu Lys Ser Leu Ser Asp Val Glu Glu Glu Glu Ala Pro 
            980                 985                 990         


Glu Asp Leu Tyr Lys Asp Phe Leu  Thr Leu Glu His Leu  Ile Cys Tyr 
        995                 1000                 1005             


Ser Phe  Gln Val Ala Lys Gly  Met Glu Phe Leu Ala  Ser Arg Lys 
    1010                 1015                 1020             


Cys Ile  His Arg Asp Leu Ala  Ala Arg Asn Ile Leu  Leu Ser Glu 
    1025                 1030                 1035             


Lys Asn  Val Val Lys Ile Cys  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1040                 1045                 1050             


Tyr Lys  Asp Pro Asp Tyr Val  Arg Lys Gly Asp Ala  Arg Leu Pro 
    1055                 1060                 1065             


Leu Lys  Trp Met Ala Pro Glu  Thr Ile Phe Asp Arg  Val Tyr Thr 
    1070                 1075                 1080             


Ile Gln  Ser Asp Val Trp Ser  Phe Gly Val Leu Leu  Trp Glu Ile 
    1085                 1090                 1095             


Phe Ser  Leu Gly Ala Ser Pro  Tyr Pro Gly Val Lys  Ile Asp Glu 
    1100                 1105                 1110             


Glu Phe  Cys Arg Arg Leu Lys  Glu Gly Thr Arg Met  Arg Ala Pro 
    1115                 1120                 1125             


Asp Tyr  Thr Thr Pro Glu Met  Tyr Gln Thr Met Leu  Asp Cys Trp 
    1130                 1135                 1140             


His Gly  Glu Pro Ser Gln Arg  Pro Thr Phe Ser Glu  Leu Val Glu 
    1145                 1150                 1155             


His Leu  Gly Asn Leu Leu Gln  Ala Asn Ala Gln Gln  Asp Gly Lys 
    1160                 1165                 1170             


Asp Tyr  Ile Val Leu Pro Ile  Ser Glu Thr Leu Ser  Met Glu Glu 
    1175                 1180                 1185             


Asp Ser  Gly Leu Ser Leu Pro  Thr Ser Pro Val Ser  Cys Met Glu 
    1190                 1195                 1200             


Glu Glu  Glu Val Cys Asp Pro  Lys Phe His Tyr Asp  Asn Thr Ala 
    1205                 1210                 1215             


Gly Ile  Ser Gln Tyr Leu Gln  Asn Ser Lys Arg Lys  Ser Arg Pro 
    1220                 1225                 1230             


Val Ser  Val Lys Thr Phe Glu  Asp Ile Pro Leu Glu  Glu Pro Glu 
    1235                 1240                 1245             


Val Lys  Val Ile Pro Asp Asp  Asn Gln Thr Asp Ser  Gly Met Val 
    1250                 1255                 1260             


Leu Ala  Ser Glu Glu Leu Lys  Thr Leu Glu Asp Arg  Thr Lys Leu 
    1265                 1270                 1275             


Ser Pro  Ser Phe Gly Gly Met  Val Pro Ser Lys Ser  Arg Glu Ser 
    1280                 1285                 1290             


Val Ala  Ser Glu Gly Ser Asn  Gln Thr Ser Gly Tyr  Gln Ser Gly 
    1295                 1300                 1305             


Tyr His  Ser Asp Asp Thr Asp  Thr Thr Val Tyr Ser  Ser Glu Glu 
    1310                 1315                 1320             


Ala Glu  Leu Leu Lys Leu Ile  Glu Ile Gly Val Gln  Thr Gly Ser 
    1325                 1330                 1335             


Thr Ala  Gln Ile Leu Gln Pro  Asp Ser Gly Thr Thr  Leu Ser Ser 
    1340                 1345                 1350             


Pro Pro  Val 
    1355     


<210>  75
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  75

Gly Leu Met Thr Lys 
1               5   


<210>  76
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH region of R2S12 or R2S12-AF

<400>  76

Gln Val Asn Leu Arg Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Thr Ser Gly Ser Ser Tyr Ile Phe Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Ser Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ala Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  77
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region of R2S12

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Asp Ile Ile Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  78
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL region of R2S12AF

<400>  78

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Asp Asp Ile Ile Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Asp Ile Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  79
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  79

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  80
<211>  1340
<212>  PRT
<213>  Mus musculus

<400>  80

Met Glu Ser Lys Ala Leu Leu Ala Val Ala Leu Trp Phe Cys Val Glu 
1               5                   10                  15      


Thr Arg Ala Ala Ser Val Gly Leu Pro Gly Asp Phe Leu His Pro Pro 
            20                  25                  30          


Lys Leu Ser Thr Gln Lys Asp Ile Leu Thr Ile Leu Ala Asn Thr Thr 
        35                  40                  45              


Leu Gln Ile Thr Cys Arg Gly Gln Arg Asp Leu Asp Trp Leu Trp Pro 
    50                  55                  60                  


Asn Ala Gln Arg Asp Ser Glu Glu Arg Val Leu Val Thr Glu Cys Gly 
65                  70                  75                  80  


Gly Gly Asp Ser Ile Phe Cys Lys Thr Leu Thr Ile Pro Arg Val Val 
                85                  90                  95      


Gly Asn Asp Thr Gly Ala Tyr Lys Cys Ser Tyr Arg Asp Val Asp Ile 
            100                 105                 110         


Ala Ser Thr Val Tyr Val Tyr Val Arg Asp Tyr Arg Ser Pro Phe Ile 
        115                 120                 125             


Ala Ser Val Ser Asp Gln His Gly Ile Val Tyr Ile Thr Glu Asn Lys 
    130                 135                 140                 


Asn Lys Thr Val Val Ile Pro Cys Arg Gly Ser Ile Ser Asn Leu Asn 
145                 150                 155                 160 


Val Ser Leu Cys Ala Arg Tyr Pro Glu Lys Arg Phe Val Pro Asp Gly 
                165                 170                 175     


Asn Arg Ile Ser Trp Asp Ser Glu Ile Gly Phe Thr Leu Pro Ser Tyr 
            180                 185                 190         


Met Ile Ser Tyr Ala Gly Met Val Phe Cys Glu Ala Lys Ile Asn Asp 
        195                 200                 205             


Glu Thr Tyr Gln Ser Ile Met Tyr Ile Val Val Val Val Gly Val Ile 
    210                 215                 220                 


Leu Ser Pro Pro His Glu Ile Glu Leu Ser Ala Gly Glu Lys Leu Val 
225                 230                 235                 240 


Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Leu Asp Phe Thr 
                245                 250                 255     


Trp His Ser Pro Pro Ser Lys Ser His His Lys Lys Ile Val Asn Arg 
            260                 265                 270         


Asp Val Lys Pro Phe Pro Gly Thr Val Ala Lys Met Phe Leu Ser Thr 
        275                 280                 285             


Leu Thr Ile Glu Ser Val Thr Lys Ser Asp Gln Gly Glu Tyr Thr Cys 
    290                 295                 300                 


Val Ala Ser Ser Gly Arg Met Ile Lys Arg Asn Arg Thr Phe Val Arg 
305                 310                 315                 320 


Val His Thr Lys Pro Phe Ile Ala Phe Gly Ser Gly Met Lys Ser Leu 
                325                 330                 335     


Val Glu Ala Thr Val Gly Ser Gln Val Arg Ile Pro Val Lys Tyr Leu 
            340                 345                 350         


Ser Tyr Pro Ala Pro Asp Ile Lys Trp Tyr Arg Asn Gly Arg Pro Ile 
        355                 360                 365             


Glu Ser Asn Tyr Thr Met Ile Val Gly Asp Glu Leu Thr Ile Met Glu 
    370                 375                 380                 


Val Thr Glu Arg Asp Ala Gly Asn Tyr Thr Val Ile Leu Thr Asn Pro 
385                 390                 395                 400 


Ile Ser Met Glu Lys Gln Ser His Met Val Ser Leu Val Val Asn Val 
                405                 410                 415     


Pro Pro Gln Ile Gly Glu Lys Ala Leu Ile Ser Pro Met Asp Ser Tyr 
            420                 425                 430         


Gln Tyr Gly Thr Met Gln Thr Leu Thr Cys Thr Val Tyr Ala Asn Pro 
        435                 440                 445             


Pro Leu His His Ile Gln Trp Tyr Trp Gln Leu Glu Glu Ala Cys Ser 
    450                 455                 460                 


Tyr Arg Pro Gly Gln Thr Ser Pro Tyr Ala Cys Lys Glu Trp Arg His 
465                 470                 475                 480 


Val Glu Asp Phe Gln Gly Gly Asn Lys Ile Glu Val Thr Lys Asn Gln 
                485                 490                 495     


Tyr Ala Leu Ile Glu Gly Lys Asn Lys Thr Val Ser Thr Leu Val Ile 
            500                 505                 510         


Gln Ala Ala Asn Val Ser Ala Leu Tyr Lys Cys Glu Ala Ile Asn Lys 
        515                 520                 525             


Ala Gly Arg Gly Glu Arg Val Ile Ser Phe His Val Ile Arg Gly Pro 
    530                 535                 540                 


Glu Ile Thr Val Gln Pro Ala Ala Gln Pro Thr Glu Gln Glu Ser Val 
545                 550                 555                 560 


Ser Leu Leu Cys Thr Ala Asp Arg Asn Thr Phe Glu Asn Leu Thr Trp 
                565                 570                 575     


Tyr Lys Leu Gly Ser Gln Ala Thr Ser Val His Met Gly Glu Ser Leu 
            580                 585                 590         


Thr Pro Val Cys Lys Asn Leu Asp Ala Leu Trp Lys Leu Asn Gly Thr 
        595                 600                 605             


Met Phe Ser Asn Ser Thr Asn Asp Ile Leu Ile Val Ala Phe Gln Asn 
    610                 615                 620                 


Ala Ser Leu Gln Asp Gln Gly Asp Tyr Val Cys Ser Ala Gln Asp Lys 
625                 630                 635                 640 


Lys Thr Lys Lys Arg His Cys Leu Val Lys Gln Leu Ile Ile Leu Glu 
                645                 650                 655     


Arg Met Ala Pro Met Ile Thr Gly Asn Leu Glu Asn Gln Thr Thr Thr 
            660                 665                 670         


Ile Gly Glu Thr Ile Glu Val Thr Cys Pro Ala Ser Gly Asn Pro Thr 
        675                 680                 685             


Pro His Ile Thr Trp Phe Lys Asp Asn Glu Thr Leu Val Glu Asp Ser 
    690                 695                 700                 


Gly Ile Val Leu Arg Asp Gly Asn Arg Asn Leu Thr Ile Arg Arg Val 
705                 710                 715                 720 


Arg Lys Glu Asp Gly Gly Leu Tyr Thr Cys Gln Ala Cys Asn Val Leu 
                725                 730                 735     


Gly Cys Ala Arg Ala Glu Thr Leu Phe Ile Ile Glu Gly Ala Gln Glu 
            740                 745                 750         


Lys Thr Asn Leu Glu Val Ile Ile Leu Val Gly Thr Ala Val Ile Ala 
        755                 760                 765             


Met Phe Phe Trp Leu Leu Leu Val Ile Val Leu Arg Thr Val Lys Arg 
    770                 775                 780                 


Ala Asn Glu Gly Glu Leu Lys Thr Gly Tyr Leu Ser Ile Val Met Asp 
785                 790                 795                 800 


Pro Asp Glu Leu Pro Leu Asp Glu Arg Cys Glu Arg Leu Pro Tyr Asp 
                805                 810                 815     


Ala Ser Lys Trp Glu Phe Pro Arg Asp Arg Leu Lys Leu Gly Lys Pro 
            820                 825                 830         


Leu Gly Arg Gly Ala Phe Gly Gln Val Ile Glu Ala Asp Ala Phe Gly 
        835                 840                 845             


Ile Asp Lys Thr Ala Thr Cys Lys Thr Val Ala Val Lys Met Leu Lys 
    850                 855                 860                 


Glu Gly Ala Thr His Ser Glu His Arg Ala Leu Met Ser Glu Leu Lys 
865                 870                 875                 880 


Ile Leu Ile His Ile Gly His His Leu Asn Val Val Asn Leu Leu Gly 
                885                 890                 895     


Ala Cys Thr Lys Pro Gly Gly Pro Leu Met Val Ile Val Glu Phe Cys 
            900                 905                 910         


Lys Phe Gly Asn Leu Ser Thr Tyr Leu Arg Gly Lys Arg Asn Glu Phe 
        915                 920                 925             


Val Pro Tyr Lys Ser Lys Gly Ala Arg Phe Arg Gln Gly Lys Asp Tyr 
    930                 935                 940                 


Val Gly Glu Leu Ser Val Asp Leu Lys Arg Arg Leu Asp Ser Ile Thr 
945                 950                 955                 960 


Ser Ser Gln Ser Ser Ala Ser Ser Gly Phe Val Glu Glu Lys Ser Leu 
                965                 970                 975     


Ser Asp Val Glu Glu Glu Glu Ala Ser Glu Glu Leu Tyr Lys Asp Phe 
            980                 985                 990         


Leu Thr Leu Glu His Leu Ile Cys  Tyr Ser Phe Gln Val  Ala Lys Gly 
        995                 1000                 1005             


Met Glu  Phe Leu Ala Ser Arg  Lys Cys Ile His Arg  Asp Leu Ala 
    1010                 1015                 1020             


Ala Arg  Asn Ile Leu Leu Ser  Glu Lys Asn Val Val  Lys Ile Cys 
    1025                 1030                 1035             


Asp Phe  Gly Leu Ala Arg Asp  Ile Tyr Lys Asp Pro  Asp Tyr Val 
    1040                 1045                 1050             


Arg Lys  Gly Asp Ala Arg Leu  Pro Leu Lys Trp Met  Ala Pro Glu 
    1055                 1060                 1065             


Thr Ile  Phe Asp Arg Val Tyr  Thr Ile Gln Ser Asp  Val Trp Ser 
    1070                 1075                 1080             


Phe Gly  Val Leu Leu Trp Glu  Ile Phe Ser Leu Gly  Ala Ser Pro 
    1085                 1090                 1095             


Tyr Pro  Gly Val Lys Ile Asp  Glu Glu Phe Cys Arg  Arg Leu Lys 
    1100                 1105                 1110             


Glu Gly  Thr Arg Met Arg Ala  Pro Asp Tyr Thr Thr  Pro Glu Met 
    1115                 1120                 1125             


Tyr Gln  Thr Met Leu Asp Cys  Trp His Glu Asp Pro  Asn Gln Arg 
    1130                 1135                 1140             


Pro Ser  Phe Ser Glu Leu Val  Glu His Leu Gly Asn  Leu Leu Gln 
    1145                 1150                 1155             


Ala Asn  Ala Gln Gln Asp Gly  Lys Asp Tyr Ile Val  Leu Pro Met 
    1160                 1165                 1170             


Ser Glu  Thr Leu Ser Met Glu  Glu Asp Ser Gly Leu  Ser Leu Pro 
    1175                 1180                 1185             


Thr Ser  Pro Val Ser Cys Met  Glu Glu Glu Glu Val  Cys Asp Pro 
    1190                 1195                 1200             


Lys Phe  His Tyr Asp Asn Thr  Ala Gly Ile Ser His  Tyr Leu Gln 
    1205                 1210                 1215             


Asn Ser  Lys Arg Lys Ser Arg  Pro Val Ser Val Lys  Thr Phe Glu 
    1220                 1225                 1230             


Asp Ile  Pro Leu Glu Glu Pro  Glu Val Lys Val Ile  Pro Asp Asp 
    1235                 1240                 1245             


Ser Gln  Thr Asp Ser Gly Met  Val Leu Ala Ser Glu  Glu Leu Lys 
    1250                 1255                 1260             


Thr Leu  Glu Asp Arg Asn Lys  Leu Ser Pro Ser Phe  Gly Gly Met 
    1265                 1270                 1275             


Met Pro  Ser Lys Ser Arg Glu  Ser Val Ala Ser Glu  Gly Ser Asn 
    1280                 1285                 1290             


Gln Thr  Ser Gly Tyr Gln Ser  Gly Tyr His Ser Asp  Asp Thr Asp 
    1295                 1300                 1305             


Thr Thr  Val Tyr Ser Ser Asp  Glu Ala Gly Leu Leu  Lys Met Val 
    1310                 1315                 1320             


Asp Ala  Ala Val His Ala Asp  Ser Gly Thr Thr Leu  Arg Ser Pro 
    1325                 1330                 1335             


Pro Val  
    1340 


