                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  METHODS OF TREATING OR PREVENTING DEMYELINATION USING THROMBIN 
       INHIBITORS AND METHODS OF DETECTING DEMYELINATION USING 
       NEUROFASCIN 155

<130>  723232

<150>  US 62/148,802
<151>  2015-04-17

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
acatcgagat cgccacctac                                                   20


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
tgcttcgact ccttaatgac c                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ttctcttcgg tgctaggaaa c                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
aggaagctta tgtctctggt g                                                 21


<210>  5
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
acttgatgag caattatcag ttacc                                             25


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
tggatgagac aaggctcact c                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
ttgactccca acaccgaatg c                                                 21


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
aggaatggga aaggtacctt gc                                                22


<210>  9
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
ctcaagtctc ttcttccaca gtg                                               23


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
ttgattctcg gtcgtgagtt ag                                                22


<210>  11
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
tgctggagcc cttccttttc c                                                 21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
tccatccagt cacatggtcc tc                                                22


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
tcctgctgtt cttggcttcc                                                   20


<210>  14
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
aacactcatg cccgtgacc                                                    19


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
aatgcatcct gcaccaccaa c                                                 21


<210>  16
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
tggatgcagg gatgatgttc tg                                                22


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
cctccgtaag aagaaacact gc                                                22


<210>  18
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
gtagcgttca gcatacatca cg                                                22


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
gccaaatgtc accatctctc c                                                 21


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
actcctgcag tcccacttcc                                                   20


<210>  21
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Asn Pro Tyr Asn Asp Ser Ser Leu Arg Asn His Pro Asp 
1               5                   10              


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Leu Glu Met Val Val Val Asn Gly Arg 
1               5                   


<210>  23
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Met Val Val Val Asn Gly Arg Gly Asp Gly Pro Arg Ser Glu 
1               5                   10                  


<210>  24
<211>  1189
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Ala Asp Gln 
    610                 615                 620                 


Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro Lys Gly Arg Pro Asp 
625                 630                 635                 640 


Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val Arg 
                645                 650                 655     


Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp Tyr 
            660                 665                 670         


Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His Asp 
        675                 680                 685             


His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu Ser 
    690                 695                 700                 


Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val Gly 
705                 710                 715                 720 


Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly Ala 
                725                 730                 735     


Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg Lys 
            740                 745                 750         


Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe 
        755                 760                 765             


Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr Arg 
    770                 775                 780                 


Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val Gly 
785                 790                 795                 800 


Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu Asn 
                805                 810                 815     


Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser Gly 
            820                 825                 830         


Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val Met 
        835                 840                 845             


Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp Thr 
    850                 855                 860                 


Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu Ser 
865                 870                 875                 880 


Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala Ser 
                885                 890                 895     


Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro Tyr 
            900                 905                 910         


Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg Gly Asp Gly 
        915                 920                 925             


Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly Val Pro Ser 
    930                 935                 940                 


Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu Thr Ile Asn 
945                 950                 955                 960 


Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met Ile Gly Tyr 
                965                 970                 975     


Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly Lys Gln Ile 
            980                 985                 990         


Val Glu Asn Phe Ser Pro Asn Gln  Thr Lys Phe Thr Val  Gln Arg Thr 
        995                 1000                 1005             


Asp Pro  Val Ser Arg Tyr Arg  Phe Thr Leu Ser Ala  Arg Thr Gln 
    1010                 1015                 1020             


Val Gly  Ser Gly Glu Ala Val  Thr Glu Glu Ser Pro  Ala Pro Pro 
    1025                 1030                 1035             


Asn Glu  Ala Thr Pro Thr Ala  Ala Tyr Thr Asn Asn  Gln Ala Asp 
    1040                 1045                 1050             


Ile Ala  Thr Gln Gly Trp Phe  Ile Gly Leu Met Cys  Ala Ile Ala 
    1055                 1060                 1065             


Leu Leu  Val Leu Ile Leu Leu  Ile Val Cys Phe Ile  Lys Arg Ser 
    1070                 1075                 1080             


Arg Gly  Gly Lys Tyr Pro Val  Arg Glu Lys Lys Asp  Val Pro Leu 
    1085                 1090                 1095             


Gly Pro  Glu Asp Pro Lys Glu  Glu Asp Gly Ser Phe  Asp Tyr Ser 
    1100                 1105                 1110             


Asp Glu  Asp Asn Lys Pro Leu  Gln Gly Ser Gln Thr  Ser Leu Asp 
    1115                 1120                 1125             


Gly Thr  Ile Lys Gln Gln Glu  Ser Asp Asp Ser Leu  Val Asp Tyr 
    1130                 1135                 1140             


Gly Glu  Gly Gly Glu Gly Gln  Phe Asn Glu Asp Gly  Ser Phe Ile 
    1145                 1150                 1155             


Gly Gln  Tyr Thr Val Lys Lys  Asp Lys Glu Glu Thr  Glu Gly Asn 
    1160                 1165                 1170             


Glu Ser  Ser Glu Ala Thr Ser  Pro Val Asn Ala Ile  Tyr Ser Leu 
    1175                 1180                 1185             


Ala 
    


<210>  25
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Arg Gln Pro Pro Pro Pro Trp Val His Ala Ala Phe Leu Leu 
1               5                   10                  15      


Cys Leu Leu Ser Leu Gly Gly Ala Ile Glu Ile Pro Met Asp Leu Thr 
            20                  25                  30          


Gln Pro Pro Thr Ile Thr Lys Gln Ser Ala Lys Asp His Ile Val Asp 
        35                  40                  45              


Pro Arg Asp Asn Ile Leu Ile Glu Cys Glu Ala Lys Gly Asn Pro Ala 
    50                  55                  60                  


Pro Ser Phe His Trp Thr Arg Asn Ser Arg Phe Phe Asn Ile Ala Lys 
65                  70                  75                  80  


Asp Pro Arg Val Ser Met Arg Arg Arg Ser Gly Thr Leu Val Ile Asp 
                85                  90                  95      


Phe Arg Ser Gly Gly Arg Pro Glu Glu Tyr Glu Gly Glu Tyr Gln Cys 
            100                 105                 110         


Phe Ala Arg Asn Lys Phe Gly Thr Ala Leu Ser Asn Arg Ile Arg Leu 
        115                 120                 125             


Gln Val Ser Lys Ser Pro Leu Trp Pro Lys Glu Asn Leu Asp Pro Val 
    130                 135                 140                 


Val Val Gln Glu Gly Ala Pro Leu Thr Leu Gln Cys Asn Pro Pro Pro 
145                 150                 155                 160 


Gly Leu Pro Ser Pro Val Ile Phe Trp Met Ser Ser Ser Met Glu Pro 
                165                 170                 175     


Ile Thr Gln Asp Lys Arg Val Ser Gln Gly His Asn Gly Asp Leu Tyr 
            180                 185                 190         


Phe Ser Asn Val Met Leu Gln Asp Met Gln Thr Asp Tyr Ser Cys Asn 
        195                 200                 205             


Ala Arg Phe His Phe Thr His Thr Ile Gln Gln Lys Asn Pro Phe Thr 
    210                 215                 220                 


Leu Lys Val Leu Thr Asn His Pro Tyr Asn Asp Ser Ser Leu Arg Asn 
225                 230                 235                 240 


His Pro Asp Met Tyr Ser Ala Arg Gly Val Ala Glu Arg Thr Pro Ser 
                245                 250                 255     


Phe Met Tyr Pro Gln Gly Thr Ala Ser Ser Gln Met Val Leu Arg Gly 
            260                 265                 270         


Met Asp Leu Leu Leu Glu Cys Ile Ala Ser Gly Val Pro Thr Pro Asp 
        275                 280                 285             


Ile Ala Trp Tyr Lys Lys Gly Gly Asp Leu Pro Ser Asp Lys Ala Lys 
    290                 295                 300                 


Phe Glu Asn Phe Asn Lys Ala Leu Arg Ile Thr Asn Val Ser Glu Glu 
305                 310                 315                 320 


Asp Ser Gly Glu Tyr Phe Cys Leu Ala Ser Asn Lys Met Gly Ser Ile 
                325                 330                 335     


Arg His Thr Ile Ser Val Arg Val Lys Ala Ala Pro Tyr Trp Leu Asp 
            340                 345                 350         


Glu Pro Lys Asn Leu Ile Leu Ala Pro Gly Glu Asp Gly Arg Leu Val 
        355                 360                 365             


Cys Arg Ala Asn Gly Asn Pro Lys Pro Thr Val Gln Trp Met Val Asn 
    370                 375                 380                 


Gly Glu Pro Leu Gln Ser Ala Pro Pro Asn Pro Asn Arg Glu Val Ala 
385                 390                 395                 400 


Gly Asp Thr Ile Ile Phe Arg Asp Thr Gln Ile Ser Ser Arg Ala Val 
                405                 410                 415     


Tyr Gln Cys Asn Thr Ser Asn Glu His Gly Tyr Leu Leu Ala Asn Ala 
            420                 425                 430         


Phe Val Ser Val Leu Asp Val Pro Pro Arg Met Leu Ser Pro Arg Asn 
        435                 440                 445             


Gln Leu Ile Arg Val Ile Leu Tyr Asn Arg Thr Arg Leu Asp Cys Pro 
    450                 455                 460                 


Phe Phe Gly Ser Pro Ile Pro Thr Leu Arg Trp Phe Lys Asn Gly Gln 
465                 470                 475                 480 


Gly Ser Asn Leu Asp Gly Gly Asn Tyr His Val Tyr Glu Asn Gly Ser 
                485                 490                 495     


Leu Glu Ile Lys Met Ile Arg Lys Glu Asp Gln Gly Ile Tyr Thr Cys 
            500                 505                 510         


Val Ala Thr Asn Ile Leu Gly Lys Ala Glu Asn Gln Val Arg Leu Glu 
        515                 520                 525             


Val Lys Asp Pro Thr Arg Ile Tyr Arg Met Pro Glu Asp Gln Val Ala 
    530                 535                 540                 


Arg Arg Gly Thr Thr Val Gln Leu Glu Cys Arg Val Lys His Asp Pro 
545                 550                 555                 560 


Ser Leu Lys Leu Thr Val Ser Trp Leu Lys Asp Asp Glu Pro Leu Tyr 
                565                 570                 575     


Ile Gly Asn Arg Met Lys Lys Glu Asp Asp Ser Leu Thr Ile Phe Gly 
            580                 585                 590         


Val Ala Glu Arg Asp Gln Gly Ser Tyr Thr Cys Val Ala Ser Thr Glu 
        595                 600                 605             


Leu Asp Gln Asp Leu Ala Lys Ala Tyr Leu Thr Val Leu Ala Asp Gln 
    610                 615                 620                 


Ala Thr Pro Thr Asn Arg Leu Ala Ala Leu Pro Lys Gly Arg Pro Asp 
625                 630                 635                 640 


Arg Pro Arg Asp Leu Glu Leu Thr Asp Leu Ala Glu Arg Ser Val Arg 
                645                 650                 655     


Leu Thr Trp Ile Pro Gly Asp Ala Asn Asn Ser Pro Ile Thr Asp Tyr 
            660                 665                 670         


Val Val Gln Phe Glu Glu Asp Gln Phe Gln Pro Gly Val Trp His Asp 
        675                 680                 685             


His Ser Lys Tyr Pro Gly Ser Val Asn Ser Ala Val Leu Arg Leu Ser 
    690                 695                 700                 


Pro Tyr Val Asn Tyr Gln Phe Arg Val Ile Ala Ile Asn Glu Val Gly 
705                 710                 715                 720 


Ser Ser His Pro Ser Leu Pro Ser Glu Arg Tyr Arg Thr Ser Gly Ala 
                725                 730                 735     


Pro Pro Glu Ser Asn Pro Gly Asp Val Lys Gly Glu Gly Thr Arg Lys 
            740                 745                 750         


Asn Asn Met Glu Ile Thr Trp Thr Pro Met Asn Ala Thr Ser Ala Phe 
        755                 760                 765             


Gly Pro Asn Leu Arg Tyr Ile Val Lys Trp Arg Arg Arg Glu Thr Arg 
    770                 775                 780                 


Glu Ala Trp Asn Asn Val Thr Val Trp Gly Ser Arg Tyr Val Val Gly 
785                 790                 795                 800 


Gln Thr Pro Val Tyr Val Pro Tyr Glu Ile Arg Val Gln Ala Glu Asn 
                805                 810                 815     


Asp Phe Gly Lys Gly Pro Glu Pro Glu Ser Val Ile Gly Tyr Ser Gly 
            820                 825                 830         


Glu Asp Tyr Pro Arg Ala Ala Pro Thr Glu Val Lys Val Arg Val Met 
        835                 840                 845             


Asn Ser Thr Ala Ile Ser Leu Gln Trp Asn Arg Val Tyr Ser Asp Thr 
    850                 855                 860                 


Val Gln Gly Gln Leu Arg Glu Tyr Arg Ala Tyr Tyr Trp Arg Glu Ser 
865                 870                 875                 880 


Ser Leu Leu Lys Asn Leu Trp Val Ser Gln Lys Arg Gln Gln Ala Ser 
                885                 890                 895     


Phe Pro Gly Asp Arg Leu Arg Gly Val Val Ser Arg Leu Phe Pro Tyr 
            900                 905                 910         


Ser Asn Tyr Lys Leu Glu Met Val Val Val Asn Gly Arg 
        915                 920                 925 


<210>  26
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Asp Gly Pro Arg Ser Glu Thr Lys Glu Phe Thr Thr Pro Glu Gly 
1               5                   10                  15      


Val Pro Ser Ala Pro Arg Arg Phe Arg Val Arg Gln Pro Asn Leu Glu 
            20                  25                  30          


Thr Ile Asn Leu Glu Trp Asp His Pro Glu His Pro Asn Gly Ile Met 
        35                  40                  45              


Ile Gly Tyr Thr Leu Lys Tyr Val Ala Phe Asn Gly Thr Lys Val Gly 
    50                  55                  60                  


Lys Gln Ile Val Glu Asn Phe Ser Pro Asn Gln Thr Lys Phe Thr Val 
65                  70                  75                  80  


Gln Arg Thr Asp Pro Val Ser Arg Tyr Arg Phe Thr Leu Ser Ala Arg 
                85                  90                  95      


Thr Gln Val Gly Ser Gly Glu Ala Val Thr Glu Glu Ser Pro Ala Pro 
            100                 105                 110         


Pro Asn Glu Ala Thr Pro Thr Ala Ala Tyr Thr Asn Asn Gln Ala Asp 
        115                 120                 125             


Ile Ala Thr Gln Gly Trp Phe Ile Gly Leu Met Cys Ala Ile Ala Leu 
    130                 135                 140                 


Leu Val Leu Ile Leu Leu Ile Val Cys Phe Ile Lys Arg Ser Arg Gly 
145                 150                 155                 160 


Gly Lys Tyr Pro Val Arg Glu Lys Lys Asp Val Pro Leu Gly Pro Glu 
                165                 170                 175     


Asp Pro Lys Glu Glu Asp Gly Ser Phe Asp Tyr Ser Asp Glu Asp Asn 
            180                 185                 190         


Lys Pro Leu Gln Gly Ser Gln Thr Ser Leu Asp Gly Thr Ile Lys Gln 
        195                 200                 205             


Gln Glu Ser Asp Asp Ser Leu Val Asp Tyr Gly Glu Gly Gly Glu Gly 
    210                 215                 220                 


Gln Phe Asn Glu Asp Gly Ser Phe Ile Gly Gln Tyr Thr Val Lys Lys 
225                 230                 235                 240 


Asp Lys Glu Glu Thr Glu Gly Asn Glu Ser Ser Glu Ala Thr Ser Pro 
                245                 250                 255     


Val Asn Ala Ile Tyr Ser Leu Ala 
            260                 


<210>  27
<211>  2018
<212>  DNA
<213>  Homo sapiens

<400>  27
gtcaggacag acaattcctc agtgacccag gagctgacac actatggcgc acgtccgagg       60

cttgcagctg cctggctgcc tggccctggc tgccctgtgt agccttgtgc acagccagca      120

tgtgttcctg gctcctcagc aagcacggtc gctgctccag cgggtccggc gagccaacac      180

cttcttggag gaggtgcgca agggcaacct ggagcgagag tgcgtggagg agacgtgcag      240

ctacgaggag gccttcgagg ctctggagtc ctccacggct acggatgtgt tctgggccaa      300

gtacacagct tgtgagacag cgaggacgcc tcgagataag cttgctgcat gtctggaagg      360

taactgtgct gagggtctgg gtacgaacta ccgagggcat gtgaacatca cccggtcagg      420

cattgagtgc cagctatgga ggagtcgcta cccacataag cctgaaatca actccactac      480

ccatcctggg gccgacctac aggagaattt ctgccgcaac cccgacagca gcaccacggg      540

accctggtgc tacactacag accccaccgt gaggaggcag gaatgcagca tccctgtctg      600

tggccaggat caagtcactg tagcgatgac tccacgctcc gaaggctcca gtgtgaatct      660

gtcacctcca ttggagcagt gtgtccctga tcgggggcag cagtaccagg ggcgcctggc      720

ggtgaccaca catgggctcc cctgcctggc ctgggccagc gcacaggcca aggccctgag      780

caagcaccag gacttcaact cagctgtgca gctggtggag aacttctgcc gcaacccaga      840

cggggatgag gagggcgtgt ggtgctatgt ggccgggaag cctggcgact ttgggtactg      900

cgacctcaac tattgtgagg aggccgtgga ggaggagaca ggagatgggc tggatgagga      960

ctcagacagg gccatcgaag ggcgtaccgc caccagtgag taccagactt tcttcaatcc     1020

gaggaccttt ggctcgggag aggcagactg tgggctgcga cctctgttcg agaagaagtc     1080

gctggaggac aaaaccgaaa gagagctcct ggaatcctac atcgacgggc gcattgtgga     1140

gggctcggat gcagagatcg gcatgtcacc ttggcaggtg atgcttttcc ggaagagtcc     1200

ccaggagctg ctgtgtgggg ccagcctcat cagtgaccgc tgggtcctca ccgccgccca     1260

ctgcctcctg tacccgccct gggacaagaa cttcaccgag aatgaccttc tggtgcgcat     1320

tggcaagcac tcccgcacca ggtacgagcg aaacattgaa aagatatcca tgttggaaaa     1380

gatctacatc caccccaggt acaactggcg ggagaacctg gaccgggaca ttgccctgat     1440

gaagctgaag aagcctgttg ccttcagtga ctacattcac cctgtgtgtc tgcccgacag     1500

ggagacggca gccagcttgc tccaggctgg atacaagggg cgggtgacag gctggggcaa     1560

cctgaaggag acgtggacag ccaacgttgg taaggggcag cccagtgtcc tgcaggtggt     1620

gaacctgccc attgtggagc ggccggtctg caaggactcc acccggatcc gcatcactga     1680

caacatgttc tgtgctggtt acaagcctga tgaagggaaa cgaggggatg cctgtgaagg     1740

tgacagtggg ggaccctttg tcatgaagag cccctttaac aaccgctggt atcaaatggg     1800

catcgtctca tggggtgaag gctgtgaccg ggatgggaaa tatggcttct acacacatgt     1860

gttccgcctg aagaagtgga tacagaaggt cattgatcag tttggagagt agggggccac     1920

tcatattctg ggctcctgga accaatcccg tgaaagaatt atttttgtgt ttctaaaact     1980

atggttccca ataaaagtga ctctcagcga aaaaaaaa                             2018


<210>  28
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Arg Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Thr Phe Leu 
        35                  40                  45              


Glu Glu Val Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu Thr 
    50                  55                  60                  


Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Ser Thr Ala Thr 
65                  70                  75                  80  


Asp Val Phe Trp Ala Lys Tyr Thr Ala Cys Glu Thr Ala Arg Thr Pro 
                85                  90                  95      


Arg Asp Lys Leu Ala Ala Cys Leu Glu Gly Asn Cys Ala Glu Gly Leu 
            100                 105                 110         


Gly Thr Asn Tyr Arg Gly His Val Asn Ile Thr Arg Ser Gly Ile Glu 
        115                 120                 125             


Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn Ser 
    130                 135                 140                 


Thr Thr His Pro Gly Ala Asp Leu Gln Glu Asn Phe Cys Arg Asn Pro 
145                 150                 155                 160 


Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr Val 
                165                 170                 175     


Arg Arg Gln Glu Cys Ser Ile Pro Val Cys Gly Gln Asp Gln Val Thr 
            180                 185                 190         


Val Ala Met Thr Pro Arg Ser Glu Gly Ser Ser Val Asn Leu Ser Pro 
        195                 200                 205             


Pro Leu Glu Gln Cys Val Pro Asp Arg Gly Gln Gln Tyr Gln Gly Arg 
    210                 215                 220                 


Leu Ala Val Thr Thr His Gly Leu Pro Cys Leu Ala Trp Ala Ser Ala 
225                 230                 235                 240 


Gln Ala Lys Ala Leu Ser Lys His Gln Asp Phe Asn Ser Ala Val Gln 
                245                 250                 255     


Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Gly Asp Glu Glu Gly Val 
            260                 265                 270         


Trp Cys Tyr Val Ala Gly Lys Pro Gly Asp Phe Gly Tyr Cys Asp Leu 
        275                 280                 285             


Asn Tyr Cys Glu Glu Ala Val Glu Glu Glu Thr Gly Asp Gly Leu Asp 
    290                 295                 300                 


Glu Asp Ser Asp Arg Ala Ile Glu Gly Arg Thr Ala Thr Ser Glu Tyr 
305                 310                 315                 320 


Gln Thr Phe Phe Asn Pro Arg Thr Phe Gly Ser Gly Glu Ala Asp Cys 
                325                 330                 335     


Gly Leu Arg Pro Leu Phe Glu Lys Lys Ser Leu Glu Asp Lys Thr Glu 
            340                 345                 350         


Arg Glu Leu Leu Glu Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Ser 
        355                 360                 365             


Asp Ala Glu Ile Gly Met Ser Pro Trp Gln Val Met Leu Phe Arg Lys 
    370                 375                 380                 


Ser Pro Gln Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp 
385                 390                 395                 400 


Val Leu Thr Ala Ala His Cys Leu Leu Tyr Pro Pro Trp Asp Lys Asn 
                405                 410                 415     


Phe Thr Glu Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr 
            420                 425                 430         


Arg Tyr Glu Arg Asn Ile Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr 
        435                 440                 445             


Ile His Pro Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala 
    450                 455                 460                 


Leu Met Lys Leu Lys Lys Pro Val Ala Phe Ser Asp Tyr Ile His Pro 
465                 470                 475                 480 


Val Cys Leu Pro Asp Arg Glu Thr Ala Ala Ser Leu Leu Gln Ala Gly 
                485                 490                 495     


Tyr Lys Gly Arg Val Thr Gly Trp Gly Asn Leu Lys Glu Thr Trp Thr 
            500                 505                 510         


Ala Asn Val Gly Lys Gly Gln Pro Ser Val Leu Gln Val Val Asn Leu 
        515                 520                 525             


Pro Ile Val Glu Arg Pro Val Cys Lys Asp Ser Thr Arg Ile Arg Ile 
    530                 535                 540                 


Thr Asp Asn Met Phe Cys Ala Gly Tyr Lys Pro Asp Glu Gly Lys Arg 
545                 550                 555                 560 


Gly Asp Ala Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser 
                565                 570                 575     


Pro Phe Asn Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu 
            580                 585                 590         


Gly Cys Asp Arg Asp Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg 
        595                 600                 605             


Leu Lys Lys Trp Ile Gln Lys Val Ile Asp Gln Phe Gly Glu 
    610                 615                 620         


<210>  29
<211>  2051
<212>  DNA
<213>  Mus musculus

<400>  29
ggttcaatat taacccagag agagtcagga caatccctca gatcccagga gctgacacac       60

tatgtcgcac gtccgcggcc tgggcctccc tggctgcttg gctctggctg ccctggttag      120

cctggtacac agccagcatg tgttcctggc gcctcagcaa gcactatcgc tgctccagcg      180

ggtccgcaga gccaacagtg gcttcctgga ggagctccga aagggcaacc tagagcgtga      240

gtgcgtggaa gagcagtgca gctatgagga ggcctttgag gccctggagt ctccccaaga      300

cacagacgtg ttctgggcca agtacacagt gtgtgattca gtgaggaaac ctcgagagac      360

tttcatggac tgtctggaag gtcgctgtgc tatggatctg ggtgtgaact accttgggac      420

tgtgaatgtc acccataccg gtatccagtg ccagctgtgg cggagccgct acccccacaa      480

gcctgaaatc aactccacca cccatcctgg ggcagacctg aaggagaact tctgccgcaa      540

tccagacagc agtaccacgg gaccctggtg ctacaccaca gatcctactg tgcgcagaga      600

ggaatgcagt gtccctgtct gtggccagga gggccgtacc actgtggtga tgactcctcg      660

ctctggaggt tccaaggaca atctgtcacc tccactggga cagtgcctca ctgagcgtgg      720

ccgactatac caggggaatt tggctgtgac aacacttggg tccccctgcc tgccctggaa      780

cagcttacca gccaagaccc tgagcaagta ccaagacttc gaccccgagg tgaaactcgt      840

ggaaaacttc tgccgcaacc cagactggga tgaggagggc gcatggtgct atgttgcggg      900

gcagcctggc gactttgaat actgcaacct caactactgc gaggaggcgg tgggagagga      960

gaactatgat gtggacgagt ccatcgcggg acgcaccacc gatgcggagt tccacacctt     1020

cttcaatgag aagaccttcg gccttgggga ggcagactgt ggcctgcggc ctttgttcga     1080

gaagaagtcg ttgaaagaca caaccgaaaa ggagcttctt gactcttaca tagacgggcg     1140

catcgtggag ggctgggacg ctgagaaggg tatcgccccc tggcaggtga tgctttttcg     1200

gaagagtccc caagagctgc tgtgtggggc cagccttatc agtgaccgat gggtcctcac     1260

tgctgcccac tgcattctgt acccaccctg ggacaagaac ttcactgaga atgacctcct     1320

ggtgcgcatt ggcaagcatt cccgaaccag atatgagcgg aatgttgaaa agatctccat     1380

gctggaaaag atctacgtcc accccagata taactggcgg gagaacctag accgcgatat     1440

cgctctgctc aagctaaaga aacctgtacc cttcagtgac tatattcacc ccgtgtgttt     1500

gccagacaag cagacagtaa ccagcttgct ccgggctggt tataaagggc gggtgacagg     1560

ctggggcaac cttcgggaga catggacaac caacatcaat gagatacagc ccagcgtcct     1620

gcaggtggtg aacctgccca ttgtagagcg gccagtgtgc aaggcctcca cccggattcg     1680

aattactgac aacatgttct gtgctggctt caaggtgaat gacaccaagc gaggagatgc     1740

ttgtgaaggt gacagtggag gaccttttgt catgaagagc ccctttaaca accgctggta     1800

tcaaatgggt attgtctcat ggggtgaagg atgtgaccgg aaggggaaat acggcttcta     1860

cacgcatgtg ttccgtctga aaaggtggat acagaaagtc attgatcaat ttggataggt     1920

gtgtgggtgg gtaaaggacc tacactatgg aatcctcatt gcaaaatcac agaaaccaat     1980

caaattactt ttgtggtttg tttctgttct caataaaagt gattgtcagt aaaaaaaaaa     2040

aaaaaaaaaa a                                                          2051


<210>  30
<211>  618
<212>  PRT
<213>  Mus musculus

<400>  30

Met Ser His Val Arg Gly Leu Gly Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Val Ser Leu Val His Ser Gln His Val Phe Leu Ala Pro Gln 
            20                  25                  30          


Gln Ala Leu Ser Leu Leu Gln Arg Val Arg Arg Ala Asn Ser Gly Phe 
        35                  40                  45              


Leu Glu Glu Leu Arg Lys Gly Asn Leu Glu Arg Glu Cys Val Glu Glu 
    50                  55                  60                  


Gln Cys Ser Tyr Glu Glu Ala Phe Glu Ala Leu Glu Ser Pro Gln Asp 
65                  70                  75                  80  


Thr Asp Val Phe Trp Ala Lys Tyr Thr Val Cys Asp Ser Val Arg Lys 
                85                  90                  95      


Pro Arg Glu Thr Phe Met Asp Cys Leu Glu Gly Arg Cys Ala Met Asp 
            100                 105                 110         


Leu Gly Val Asn Tyr Leu Gly Thr Val Asn Val Thr His Thr Gly Ile 
        115                 120                 125             


Gln Cys Gln Leu Trp Arg Ser Arg Tyr Pro His Lys Pro Glu Ile Asn 
    130                 135                 140                 


Ser Thr Thr His Pro Gly Ala Asp Leu Lys Glu Asn Phe Cys Arg Asn 
145                 150                 155                 160 


Pro Asp Ser Ser Thr Thr Gly Pro Trp Cys Tyr Thr Thr Asp Pro Thr 
                165                 170                 175     


Val Arg Arg Glu Glu Cys Ser Val Pro Val Cys Gly Gln Glu Gly Arg 
            180                 185                 190         


Thr Thr Val Val Met Thr Pro Arg Ser Gly Gly Ser Lys Asp Asn Leu 
        195                 200                 205             


Ser Pro Pro Leu Gly Gln Cys Leu Thr Glu Arg Gly Arg Leu Tyr Gln 
    210                 215                 220                 


Gly Asn Leu Ala Val Thr Thr Leu Gly Ser Pro Cys Leu Pro Trp Asn 
225                 230                 235                 240 


Ser Leu Pro Ala Lys Thr Leu Ser Lys Tyr Gln Asp Phe Asp Pro Glu 
                245                 250                 255     


Val Lys Leu Val Glu Asn Phe Cys Arg Asn Pro Asp Trp Asp Glu Glu 
            260                 265                 270         


Gly Ala Trp Cys Tyr Val Ala Gly Gln Pro Gly Asp Phe Glu Tyr Cys 
        275                 280                 285             


Asn Leu Asn Tyr Cys Glu Glu Ala Val Gly Glu Glu Asn Tyr Asp Val 
    290                 295                 300                 


Asp Glu Ser Ile Ala Gly Arg Thr Thr Asp Ala Glu Phe His Thr Phe 
305                 310                 315                 320 


Phe Asn Glu Lys Thr Phe Gly Leu Gly Glu Ala Asp Cys Gly Leu Arg 
                325                 330                 335     


Pro Leu Phe Glu Lys Lys Ser Leu Lys Asp Thr Thr Glu Lys Glu Leu 
            340                 345                 350         


Leu Asp Ser Tyr Ile Asp Gly Arg Ile Val Glu Gly Trp Asp Ala Glu 
        355                 360                 365             


Lys Gly Ile Ala Pro Trp Gln Val Met Leu Phe Arg Lys Ser Pro Gln 
    370                 375                 380                 


Glu Leu Leu Cys Gly Ala Ser Leu Ile Ser Asp Arg Trp Val Leu Thr 
385                 390                 395                 400 


Ala Ala His Cys Ile Leu Tyr Pro Pro Trp Asp Lys Asn Phe Thr Glu 
                405                 410                 415     


Asn Asp Leu Leu Val Arg Ile Gly Lys His Ser Arg Thr Arg Tyr Glu 
            420                 425                 430         


Arg Asn Val Glu Lys Ile Ser Met Leu Glu Lys Ile Tyr Val His Pro 
        435                 440                 445             


Arg Tyr Asn Trp Arg Glu Asn Leu Asp Arg Asp Ile Ala Leu Leu Lys 
    450                 455                 460                 


Leu Lys Lys Pro Val Pro Phe Ser Asp Tyr Ile His Pro Val Cys Leu 
465                 470                 475                 480 


Pro Asp Lys Gln Thr Val Thr Ser Leu Leu Arg Ala Gly Tyr Lys Gly 
                485                 490                 495     


Arg Val Thr Gly Trp Gly Asn Leu Arg Glu Thr Trp Thr Thr Asn Ile 
            500                 505                 510         


Asn Glu Ile Gln Pro Ser Val Leu Gln Val Val Asn Leu Pro Ile Val 
        515                 520                 525             


Glu Arg Pro Val Cys Lys Ala Ser Thr Arg Ile Arg Ile Thr Asp Asn 
    530                 535                 540                 


Met Phe Cys Ala Gly Phe Lys Val Asn Asp Thr Lys Arg Gly Asp Ala 
545                 550                 555                 560 


Cys Glu Gly Asp Ser Gly Gly Pro Phe Val Met Lys Ser Pro Phe Asn 
                565                 570                 575     


Asn Arg Trp Tyr Gln Met Gly Ile Val Ser Trp Gly Glu Gly Cys Asp 
            580                 585                 590         


Arg Lys Gly Lys Tyr Gly Phe Tyr Thr His Val Phe Arg Leu Lys Arg 
        595                 600                 605             


Trp Ile Gln Lys Val Ile Asp Gln Phe Gly 
    610                 615             


<210>  31
<211>  3
<212>  PRT
<213>  Homo sapiens

<400>  31

Gly Arg Gly 
1           


<210>  32
<211>  1385
<212>  PRT
<213>  Mus musculus

<400>  32

Met Met Ser Leu Arg Leu Phe Ser Ile Leu Leu Ala Thr Val Val Ser 
1               5                   10                  15      


Gly Ala Trp Gly Trp Gly Tyr Tyr Gly Cys Asn Glu Glu Leu Val Gly 
            20                  25                  30          


Pro Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Gly Leu Phe 
        35                  40                  45              


Thr Thr Ala Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro 
    50                  55                  60                  


Arg Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys 
65                  70                  75                  80  


His Arg Ile Arg Ala Val Ala Thr Gln Gly Ala Phe Asn Ser Trp Asp 
                85                  90                  95      


Trp Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp 
            100                 105                 110         


Thr Pro Phe Tyr Gln Lys Gly His Asn Ala Thr Phe Phe Gly Asn Val 
        115                 120                 125             


Asn Asp Ser Ala Val Val Arg His Asp Leu His Tyr His Phe Thr Ala 
    130                 135                 140                 


Arg Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile 
145                 150                 155                 160 


Gly Leu Arg Leu Gly Ile Tyr Gly Cys Pro Tyr Thr Ser Ser Ile Leu 
                165                 170                 175     


Tyr Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Gln Arg Gly Ala 
            180                 185                 190         


Ser Gln Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu 
        195                 200                 205             


Lys Asp Gly Leu Leu Leu His Thr Glu Gly Ser Gln Gly Asp Tyr Val 
    210                 215                 220                 


Thr Leu Glu Leu Gln Gly Ala His Leu Leu Leu His Met Ser Leu Gly 
225                 230                 235                 240 


Ser Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Leu Gly 
                245                 250                 255     


Gly Val Leu Asn Asp Leu Ser Trp His Tyr Val Arg Val Asp Arg Tyr 
            260                 265                 270         


Gly Arg Asp Ala Asn Phe Thr Leu Asp Gly Tyr Ala His His Phe Val 
        275                 280                 285             


Leu Asn Gly Asp Phe Glu Arg Leu Asn Leu Glu Asn Glu Ile Phe Ile 
    290                 295                 300                 


Gly Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn 
305                 310                 315                 320 


Phe Arg Gly Cys Ile Glu Asn Val Ile Tyr Asn Arg Ile Asn Ile Ala 
                325                 330                 335     


Glu Met Ala Val Met Arg His Ser Arg Ile Thr Phe Glu Gly Asn Val 
            340                 345                 350         


Ala Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly 
        355                 360                 365             


Pro His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu 
    370                 375                 380                 


Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu 
385                 390                 395                 400 


Phe Ser His Leu Gly Asp Gly Leu Gly His Val Glu Leu Met Leu Ser 
                405                 410                 415     


Glu Gly Gln Val Asn Val Ser Ile Ala Gln Thr Gly Arg Lys Lys Leu 
            420                 425                 430         


Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val 
        435                 440                 445             


Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val 
    450                 455                 460                 


Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly 
465                 470                 475                 480 


Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Gly 
                485                 490                 495     


Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys 
            500                 505                 510         


Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Phe Arg Lys Leu 
        515                 520                 525             


Gly Tyr Phe Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg 
    530                 535                 540                 


Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp 
545                 550                 555                 560 


Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Val Thr 
                565                 570                 575     


Cys His Glu Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser 
            580                 585                 590         


Gly Lys Tyr Ser Gly Asn Tyr Thr Ile Asp Pro Asp Gly Ser Gly Pro 
        595                 600                 605             


Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp 
    610                 615                 620                 


Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser 
625                 630                 635                 640 


Ser Met Asp Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser 
                645                 650                 655     


Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln 
            660                 665                 670         


Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly 
        675                 680                 685             


Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe 
    690                 695                 700                 


Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu 
705                 710                 715                 720 


Asp Gln Ser Cys Val Asp Pro Ala Leu His Cys Asn Cys Asp Ala Asp 
                725                 730                 735     


Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His 
            740                 745                 750         


Leu Pro Val Thr Gln Val Val Val Gly Asp Thr Asn Arg Ser Asn Ser 
        755                 760                 765             


Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn 
    770                 775                 780                 


Ser Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro 
785                 790                 795                 800 


Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr 
                805                 810                 815     


Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Phe Cys 
            820                 825                 830         


Arg Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp 
        835                 840                 845             


Val Val Phe Ala Phe Asp Ile Gly Asn Gly Asp Glu Asn Leu Thr Val 
    850                 855                 860                 


His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg 
865                 870                 875                 880 


Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro 
                885                 890                 895     


Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Leu Val Tyr 
            900                 905                 910         


Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe 
        915                 920                 925             


Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu 
    930                 935                 940                 


Glu Gly Arg Ala Asn Ala Ser Glu Gly Thr Phe Pro Asn Cys Thr Gly 
945                 950                 955                 960 


His Cys Thr His Pro Arg Phe Pro Cys Phe His Gly Gly Arg Cys Val 
                965                 970                 975     


Glu Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp 
            980                 985                 990         


Gly Pro Tyr Cys Asn His Asp Ile  Gly Gly Phe Phe Glu  Thr Gly Thr 
        995                 1000                 1005             


Trp Met  Arg Tyr Asn Leu Gln  Ser Ala Leu Arg Ser  Ala Ala Arg 
    1010                 1015                 1020             


Glu Phe  Ser His Met Leu Ser  Arg Pro Val Pro Gly  Tyr Glu Pro 
    1025                 1030                 1035             


Gly Tyr  Val Pro Gly Tyr Asp  Thr Pro Gly Tyr Val  Pro Gly Tyr 
    1040                 1045                 1050             


His Gly  Pro Gly Tyr Arg Leu  Pro Glu Tyr Pro Arg  Pro Gly Arg 
    1055                 1060                 1065             


Pro Val  Pro Gly Tyr Arg Gly  Pro Val Tyr Asn Val  Thr Gly Glu 
    1070                 1075                 1080             


Glu Val  Ser Phe Ser Phe Ser  Thr Asn Ser Ala Pro  Ala Val Leu 
    1085                 1090                 1095             


Leu Tyr  Val Ser Ser Phe Val  Arg Asp Tyr Met Ala  Val Leu Ile 
    1100                 1105                 1110             


Lys Glu  Asp Gly Thr Leu Gln  Leu Arg Tyr Gln Leu  Gly Thr Ser 
    1115                 1120                 1125             


Pro Tyr  Val Tyr Gln Leu Thr  Thr Arg Pro Val Thr  Asp Gly Gln 
    1130                 1135                 1140             


Pro His  Ser Val Asn Ile Thr  Arg Val Tyr Arg Asn  Leu Phe Ile 
    1145                 1150                 1155             


Gln Val  Asp Tyr Phe Pro Leu  Thr Glu Gln Lys Phe  Ser Leu Leu 
    1160                 1165                 1170             


Val Asp  Ser Gln Leu Asp Ser  Pro Lys Ala Leu Tyr  Leu Gly Arg 
    1175                 1180                 1185             


Val Met  Glu Thr Gly Val Ile  Asp Pro Glu Ile Gln  Arg Tyr Asn 
    1190                 1195                 1200             


Thr Pro  Gly Phe Ser Gly Cys  Leu Ser Gly Val Arg  Phe Asn Asn 
    1205                 1210                 1215             


Val Ala  Pro Leu Lys Thr His  Phe Arg Thr Pro Arg  Pro Met Thr 
    1220                 1225                 1230             


Ala Glu  Leu Ala Glu Ala Met  Arg Val Gln Gly Glu  Leu Ser Glu 
    1235                 1240                 1245             


Ser Asn  Cys Gly Ala Met Pro  Arg Leu Val Ser Glu  Val Pro Pro 
    1250                 1255                 1260             


Glu Leu  Asp Pro Trp Tyr Leu  Pro Pro Asp Phe Pro  Tyr Tyr His 
    1265                 1270                 1275             


Asp Asp  Gly Trp Ile Ala Ile  Leu Leu Gly Phe Leu  Val Ala Phe 
    1280                 1285                 1290             


Leu Leu  Leu Gly Leu Val Gly  Met Leu Val Leu Phe  Tyr Leu Gln 
    1295                 1300                 1305             


Asn His  Arg Tyr Lys Gly Ser  Tyr His Thr Asn Glu  Pro Lys Ala 
    1310                 1315                 1320             


Thr His  Asp Ser His Pro Gly  Gly Lys Ala Pro Leu  Pro Pro Ser 
    1325                 1330                 1335             


Gly Pro  Ala Gln Ala Pro Ala  Pro Thr Pro Ala Pro  Thr Gln Leu 
    1340                 1345                 1350             


Pro Thr  Pro Ala Pro Ala Pro  Ala Pro Ala Pro Ala  Ser Gly Pro 
    1355                 1360                 1365             


Gly Pro  Arg Asp Gln Asn Leu  Pro Gln Ile Leu Glu  Glu Ser Arg 
    1370                 1375                 1380             


Ser Glu  
    1385 


<210>  33
<211>  380
<212>  PRT
<213>  Mus musculus

<400>  33

Met Met Ser Leu Arg Leu Phe Ser Ile Leu Leu Ala Thr Val Val Ser 
1               5                   10                  15      


Gly Ala Trp Gly Trp Gly Tyr Tyr Gly Cys Asn Glu Glu Leu Val Gly 
            20                  25                  30          


Pro Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Gly Leu Phe 
        35                  40                  45              


Thr Thr Ala Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro 
    50                  55                  60                  


Arg Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys 
65                  70                  75                  80  


His Arg Ile Arg Ala Val Ala Thr Gln Gly Ala Phe Asn Ser Trp Asp 
                85                  90                  95      


Trp Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp 
            100                 105                 110         


Thr Pro Phe Tyr Gln Lys Gly His Asn Ala Thr Phe Phe Gly Asn Val 
        115                 120                 125             


Asn Asp Ser Ala Val Val Arg His Asp Leu His Tyr His Phe Thr Ala 
    130                 135                 140                 


Arg Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile 
145                 150                 155                 160 


Gly Leu Arg Leu Gly Ile Tyr Gly Cys Pro Tyr Thr Ser Ser Ile Leu 
                165                 170                 175     


Tyr Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Gln Arg Gly Ala 
            180                 185                 190         


Ser Gln Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu 
        195                 200                 205             


Lys Asp Gly Leu Leu Leu His Thr Glu Gly Ser Gln Gly Asp Tyr Val 
    210                 215                 220                 


Thr Leu Glu Leu Gln Gly Ala His Leu Leu Leu His Met Ser Leu Gly 
225                 230                 235                 240 


Ser Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Leu Gly 
                245                 250                 255     


Gly Val Leu Asn Asp Leu Ser Trp His Tyr Val Arg Val Asp Arg Tyr 
            260                 265                 270         


Gly Arg Asp Ala Asn Phe Thr Leu Asp Gly Tyr Ala His His Phe Val 
        275                 280                 285             


Leu Asn Gly Asp Phe Glu Arg Leu Asn Leu Glu Asn Glu Ile Phe Ile 
    290                 295                 300                 


Gly Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn 
305                 310                 315                 320 


Phe Arg Gly Cys Ile Glu Asn Val Ile Tyr Asn Arg Ile Asn Ile Ala 
                325                 330                 335     


Glu Met Ala Val Met Arg His Ser Arg Ile Thr Phe Glu Gly Asn Val 
            340                 345                 350         


Ala Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly 
        355                 360                 365             


Pro His Asn Phe Val Gln Val Pro Gly Phe Pro Arg 
    370                 375                 380 


<210>  34
<211>  1005
<212>  PRT
<213>  Mus musculus

<400>  34

Arg Gly Arg Leu Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr 
1               5                   10                  15      


Gly Leu Leu Leu Phe Ser His Leu Gly Asp Gly Leu Gly His Val Glu 
            20                  25                  30          


Leu Met Leu Ser Glu Gly Gln Val Asn Val Ser Ile Ala Gln Thr Gly 
        35                  40                  45              


Arg Lys Lys Leu Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe 
    50                  55                  60                  


Trp His Glu Val Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser 
65                  70                  75                  80  


Ile Asp Asp Val Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu 
                85                  90                  95      


Ile Arg Thr Gly Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala 
            100                 105                 110         


Ser Arg Trp Gly Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met 
        115                 120                 125             


Glu Leu Leu Lys Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu 
    130                 135                 140                 


Phe Arg Lys Leu Gly Tyr Phe Ala Glu Val Leu Phe Asp Thr Cys Gly 
145                 150                 155                 160 


Ile Thr Asp Arg Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys 
                165                 170                 175     


Tyr Gln Ser Trp Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr 
            180                 185                 190         


Lys Gly Val Thr Cys His Glu Pro Leu Tyr Lys Glu Ser Cys Glu Ala 
        195                 200                 205             


Tyr Arg Leu Ser Gly Lys Tyr Ser Gly Asn Tyr Thr Ile Asp Pro Asp 
    210                 215                 220                 


Gly Ser Gly Pro Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu 
225                 230                 235                 240 


Asn Arg Ala Trp Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg 
                245                 250                 255     


Val Thr Gly Ser Ser Met Asp Arg Pro Phe Leu Gly Ala Ile Gln Tyr 
            260                 265                 270         


Trp Asn Ala Ser Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln 
        275                 280                 285             


His Cys Glu Gln Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu 
    290                 295                 300                 


Asn Thr Ala Gly Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu 
305                 310                 315                 320 


Glu Gln His Phe Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys 
                325                 330                 335     


Ala Cys Gly Leu Asp Gln Ser Cys Val Asp Pro Ala Leu His Cys Asn 
            340                 345                 350         


Cys Asp Ala Asp Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr 
        355                 360                 365             


Phe Val Asp His Leu Pro Val Thr Gln Val Val Val Gly Asp Thr Asn 
    370                 375                 380                 


Arg Ser Asn Ser Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr 
385                 390                 395                 400 


Gly Asp Arg Asn Ser Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala 
                405                 410                 415     


Leu Arg Phe Pro Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe 
            420                 425                 430         


Tyr Phe Arg Thr Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly 
        435                 440                 445             


Gly Pro Phe Cys Arg Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn 
    450                 455                 460                 


Thr Ser Arg Asp Val Val Phe Ala Phe Asp Ile Gly Asn Gly Asp Glu 
465                 470                 475                 480 


Asn Leu Thr Val His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp 
                485                 490                 495     


His Leu Val Arg Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val 
            500                 505                 510         


Asp His Arg Pro Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile 
        515                 520                 525             


Trp Leu Val Tyr Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys 
    530                 535                 540                 


Arg Arg Pro Phe Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val 
545                 550                 555                 560 


Thr Leu Asn Leu Glu Gly Arg Ala Asn Ala Ser Glu Gly Thr Phe Pro 
                565                 570                 575     


Asn Cys Thr Gly His Cys Thr His Pro Arg Phe Pro Cys Phe His Gly 
            580                 585                 590         


Gly Arg Cys Val Glu Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu 
        595                 600                 605             


Thr Ala Phe Asp Gly Pro Tyr Cys Asn His Asp Ile Gly Gly Phe Phe 
    610                 615                 620                 


Glu Thr Gly Thr Trp Met Arg Tyr Asn Leu Gln Ser Ala Leu Arg Ser 
625                 630                 635                 640 


Ala Ala Arg Glu Phe Ser His Met Leu Ser Arg Pro Val Pro Gly Tyr 
                645                 650                 655     


Glu Pro Gly Tyr Val Pro Gly Tyr Asp Thr Pro Gly Tyr Val Pro Gly 
            660                 665                 670         


Tyr His Gly Pro Gly Tyr Arg Leu Pro Glu Tyr Pro Arg Pro Gly Arg 
        675                 680                 685             


Pro Val Pro Gly Tyr Arg Gly Pro Val Tyr Asn Val Thr Gly Glu Glu 
    690                 695                 700                 


Val Ser Phe Ser Phe Ser Thr Asn Ser Ala Pro Ala Val Leu Leu Tyr 
705                 710                 715                 720 


Val Ser Ser Phe Val Arg Asp Tyr Met Ala Val Leu Ile Lys Glu Asp 
                725                 730                 735     


Gly Thr Leu Gln Leu Arg Tyr Gln Leu Gly Thr Ser Pro Tyr Val Tyr 
            740                 745                 750         


Gln Leu Thr Thr Arg Pro Val Thr Asp Gly Gln Pro His Ser Val Asn 
        755                 760                 765             


Ile Thr Arg Val Tyr Arg Asn Leu Phe Ile Gln Val Asp Tyr Phe Pro 
    770                 775                 780                 


Leu Thr Glu Gln Lys Phe Ser Leu Leu Val Asp Ser Gln Leu Asp Ser 
785                 790                 795                 800 


Pro Lys Ala Leu Tyr Leu Gly Arg Val Met Glu Thr Gly Val Ile Asp 
                805                 810                 815     


Pro Glu Ile Gln Arg Tyr Asn Thr Pro Gly Phe Ser Gly Cys Leu Ser 
            820                 825                 830         


Gly Val Arg Phe Asn Asn Val Ala Pro Leu Lys Thr His Phe Arg Thr 
        835                 840                 845             


Pro Arg Pro Met Thr Ala Glu Leu Ala Glu Ala Met Arg Val Gln Gly 
    850                 855                 860                 


Glu Leu Ser Glu Ser Asn Cys Gly Ala Met Pro Arg Leu Val Ser Glu 
865                 870                 875                 880 


Val Pro Pro Glu Leu Asp Pro Trp Tyr Leu Pro Pro Asp Phe Pro Tyr 
                885                 890                 895     


Tyr His Asp Asp Gly Trp Ile Ala Ile Leu Leu Gly Phe Leu Val Ala 
            900                 905                 910         


Phe Leu Leu Leu Gly Leu Val Gly Met Leu Val Leu Phe Tyr Leu Gln 
        915                 920                 925             


Asn His Arg Tyr Lys Gly Ser Tyr His Thr Asn Glu Pro Lys Ala Thr 
    930                 935                 940                 


His Asp Ser His Pro Gly Gly Lys Ala Pro Leu Pro Pro Ser Gly Pro 
945                 950                 955                 960 


Ala Gln Ala Pro Ala Pro Thr Pro Ala Pro Thr Gln Leu Pro Thr Pro 
                965                 970                 975     


Ala Pro Ala Pro Ala Pro Ala Pro Ala Ser Gly Pro Gly Pro Arg Asp 
            980                 985                 990         


Gln Asn Leu Pro Gln Ile Leu Glu  Glu Ser Arg Ser Glu  
        995                 1000                 1005 


<210>  35
<211>  947
<212>  PRT
<213>  Mus musculus

<400>  35

Met Met Ser Leu Arg Leu Phe Ser Ile Leu Leu Ala Thr Val Val Ser 
1               5                   10                  15      


Gly Ala Trp Gly Trp Gly Tyr Tyr Gly Cys Asn Glu Glu Leu Val Gly 
            20                  25                  30          


Pro Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Gly Leu Phe 
        35                  40                  45              


Thr Thr Ala Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro 
    50                  55                  60                  


Arg Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys 
65                  70                  75                  80  


His Arg Ile Arg Ala Val Ala Thr Gln Gly Ala Phe Asn Ser Trp Asp 
                85                  90                  95      


Trp Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp 
            100                 105                 110         


Thr Pro Phe Tyr Gln Lys Gly His Asn Ala Thr Phe Phe Gly Asn Val 
        115                 120                 125             


Asn Asp Ser Ala Val Val Arg His Asp Leu His Tyr His Phe Thr Ala 
    130                 135                 140                 


Arg Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile 
145                 150                 155                 160 


Gly Leu Arg Leu Gly Ile Tyr Gly Cys Pro Tyr Thr Ser Ser Ile Leu 
                165                 170                 175     


Tyr Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Gln Arg Gly Ala 
            180                 185                 190         


Ser Gln Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu 
        195                 200                 205             


Lys Asp Gly Leu Leu Leu His Thr Glu Gly Ser Gln Gly Asp Tyr Val 
    210                 215                 220                 


Thr Leu Glu Leu Gln Gly Ala His Leu Leu Leu His Met Ser Leu Gly 
225                 230                 235                 240 


Ser Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Leu Gly 
                245                 250                 255     


Gly Val Leu Asn Asp Leu Ser Trp His Tyr Val Arg Val Asp Arg Tyr 
            260                 265                 270         


Gly Arg Asp Ala Asn Phe Thr Leu Asp Gly Tyr Ala His His Phe Val 
        275                 280                 285             


Leu Asn Gly Asp Phe Glu Arg Leu Asn Leu Glu Asn Glu Ile Phe Ile 
    290                 295                 300                 


Gly Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn 
305                 310                 315                 320 


Phe Arg Gly Cys Ile Glu Asn Val Ile Tyr Asn Arg Ile Asn Ile Ala 
                325                 330                 335     


Glu Met Ala Val Met Arg His Ser Arg Ile Thr Phe Glu Gly Asn Val 
            340                 345                 350         


Ala Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly 
        355                 360                 365             


Pro His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu 
    370                 375                 380                 


Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu 
385                 390                 395                 400 


Phe Ser His Leu Gly Asp Gly Leu Gly His Val Glu Leu Met Leu Ser 
                405                 410                 415     


Glu Gly Gln Val Asn Val Ser Ile Ala Gln Thr Gly Arg Lys Lys Leu 
            420                 425                 430         


Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val 
        435                 440                 445             


Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val 
    450                 455                 460                 


Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly 
465                 470                 475                 480 


Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Gly 
                485                 490                 495     


Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys 
            500                 505                 510         


Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Phe Arg Lys Leu 
        515                 520                 525             


Gly Tyr Phe Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg 
    530                 535                 540                 


Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp 
545                 550                 555                 560 


Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Val Thr 
                565                 570                 575     


Cys His Glu Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser 
            580                 585                 590         


Gly Lys Tyr Ser Gly Asn Tyr Thr Ile Asp Pro Asp Gly Ser Gly Pro 
        595                 600                 605             


Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp 
    610                 615                 620                 


Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser 
625                 630                 635                 640 


Ser Met Asp Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser 
                645                 650                 655     


Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln 
            660                 665                 670         


Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly 
        675                 680                 685             


Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe 
    690                 695                 700                 


Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu 
705                 710                 715                 720 


Asp Gln Ser Cys Val Asp Pro Ala Leu His Cys Asn Cys Asp Ala Asp 
                725                 730                 735     


Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His 
            740                 745                 750         


Leu Pro Val Thr Gln Val Val Val Gly Asp Thr Asn Arg Ser Asn Ser 
        755                 760                 765             


Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn 
    770                 775                 780                 


Ser Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro 
785                 790                 795                 800 


Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr 
                805                 810                 815     


Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Phe Cys 
            820                 825                 830         


Arg Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp 
        835                 840                 845             


Val Val Phe Ala Phe Asp Ile Gly Asn Gly Asp Glu Asn Leu Thr Val 
    850                 855                 860                 


His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg 
865                 870                 875                 880 


Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro 
                885                 890                 895     


Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Leu Val Tyr 
            900                 905                 910         


Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe 
        915                 920                 925             


Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu 
    930                 935                 940                 


Glu Gly Arg 
945         


<210>  36
<211>  438
<212>  PRT
<213>  Mus musculus

<400>  36

Ala Asn Ala Ser Glu Gly Thr Phe Pro Asn Cys Thr Gly His Cys Thr 
1               5                   10                  15      


His Pro Arg Phe Pro Cys Phe His Gly Gly Arg Cys Val Glu Arg Tyr 
            20                  25                  30          


Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly Pro Tyr 
        35                  40                  45              


Cys Asn His Asp Ile Gly Gly Phe Phe Glu Thr Gly Thr Trp Met Arg 
    50                  55                  60                  


Tyr Asn Leu Gln Ser Ala Leu Arg Ser Ala Ala Arg Glu Phe Ser His 
65                  70                  75                  80  


Met Leu Ser Arg Pro Val Pro Gly Tyr Glu Pro Gly Tyr Val Pro Gly 
                85                  90                  95      


Tyr Asp Thr Pro Gly Tyr Val Pro Gly Tyr His Gly Pro Gly Tyr Arg 
            100                 105                 110         


Leu Pro Glu Tyr Pro Arg Pro Gly Arg Pro Val Pro Gly Tyr Arg Gly 
        115                 120                 125             


Pro Val Tyr Asn Val Thr Gly Glu Glu Val Ser Phe Ser Phe Ser Thr 
    130                 135                 140                 


Asn Ser Ala Pro Ala Val Leu Leu Tyr Val Ser Ser Phe Val Arg Asp 
145                 150                 155                 160 


Tyr Met Ala Val Leu Ile Lys Glu Asp Gly Thr Leu Gln Leu Arg Tyr 
                165                 170                 175     


Gln Leu Gly Thr Ser Pro Tyr Val Tyr Gln Leu Thr Thr Arg Pro Val 
            180                 185                 190         


Thr Asp Gly Gln Pro His Ser Val Asn Ile Thr Arg Val Tyr Arg Asn 
        195                 200                 205             


Leu Phe Ile Gln Val Asp Tyr Phe Pro Leu Thr Glu Gln Lys Phe Ser 
    210                 215                 220                 


Leu Leu Val Asp Ser Gln Leu Asp Ser Pro Lys Ala Leu Tyr Leu Gly 
225                 230                 235                 240 


Arg Val Met Glu Thr Gly Val Ile Asp Pro Glu Ile Gln Arg Tyr Asn 
                245                 250                 255     


Thr Pro Gly Phe Ser Gly Cys Leu Ser Gly Val Arg Phe Asn Asn Val 
            260                 265                 270         


Ala Pro Leu Lys Thr His Phe Arg Thr Pro Arg Pro Met Thr Ala Glu 
        275                 280                 285             


Leu Ala Glu Ala Met Arg Val Gln Gly Glu Leu Ser Glu Ser Asn Cys 
    290                 295                 300                 


Gly Ala Met Pro Arg Leu Val Ser Glu Val Pro Pro Glu Leu Asp Pro 
305                 310                 315                 320 


Trp Tyr Leu Pro Pro Asp Phe Pro Tyr Tyr His Asp Asp Gly Trp Ile 
                325                 330                 335     


Ala Ile Leu Leu Gly Phe Leu Val Ala Phe Leu Leu Leu Gly Leu Val 
            340                 345                 350         


Gly Met Leu Val Leu Phe Tyr Leu Gln Asn His Arg Tyr Lys Gly Ser 
        355                 360                 365             


Tyr His Thr Asn Glu Pro Lys Ala Thr His Asp Ser His Pro Gly Gly 
    370                 375                 380                 


Lys Ala Pro Leu Pro Pro Ser Gly Pro Ala Gln Ala Pro Ala Pro Thr 
385                 390                 395                 400 


Pro Ala Pro Thr Gln Leu Pro Thr Pro Ala Pro Ala Pro Ala Pro Ala 
                405                 410                 415     


Pro Ala Ser Gly Pro Gly Pro Arg Asp Gln Asn Leu Pro Gln Ile Leu 
            420                 425                 430         


Glu Glu Ser Arg Ser Glu 
        435             


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Arg Arg Gly 
1           


<210>  38
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Leu Glu Gly Arg 
1               


<210>  39
<211>  567
<212>  PRT
<213>  Mus musculus

<400>  39

Arg Gly Arg Leu Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr 
1               5                   10                  15      


Gly Leu Leu Leu Phe Ser His Leu Gly Asp Gly Leu Gly His Val Glu 
            20                  25                  30          


Leu Met Leu Ser Glu Gly Gln Val Asn Val Ser Ile Ala Gln Thr Gly 
        35                  40                  45              


Arg Lys Lys Leu Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe 
    50                  55                  60                  


Trp His Glu Val Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser 
65                  70                  75                  80  


Ile Asp Asp Val Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu 
                85                  90                  95      


Ile Arg Thr Gly Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala 
            100                 105                 110         


Ser Arg Trp Gly Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met 
        115                 120                 125             


Glu Leu Leu Lys Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu 
    130                 135                 140                 


Phe Arg Lys Leu Gly Tyr Phe Ala Glu Val Leu Phe Asp Thr Cys Gly 
145                 150                 155                 160 


Ile Thr Asp Arg Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys 
                165                 170                 175     


Tyr Gln Ser Trp Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr 
            180                 185                 190         


Lys Gly Val Thr Cys His Glu Pro Leu Tyr Lys Glu Ser Cys Glu Ala 
        195                 200                 205             


Tyr Arg Leu Ser Gly Lys Tyr Ser Gly Asn Tyr Thr Ile Asp Pro Asp 
    210                 215                 220                 


Gly Ser Gly Pro Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu 
225                 230                 235                 240 


Asn Arg Ala Trp Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg 
                245                 250                 255     


Val Thr Gly Ser Ser Met Asp Arg Pro Phe Leu Gly Ala Ile Gln Tyr 
            260                 265                 270         


Trp Asn Ala Ser Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln 
        275                 280                 285             


His Cys Glu Gln Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu 
    290                 295                 300                 


Asn Thr Ala Gly Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu 
305                 310                 315                 320 


Glu Gln His Phe Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys 
                325                 330                 335     


Ala Cys Gly Leu Asp Gln Ser Cys Val Asp Pro Ala Leu His Cys Asn 
            340                 345                 350         


Cys Asp Ala Asp Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr 
        355                 360                 365             


Phe Val Asp His Leu Pro Val Thr Gln Val Val Val Gly Asp Thr Asn 
    370                 375                 380                 


Arg Ser Asn Ser Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr 
385                 390                 395                 400 


Gly Asp Arg Asn Ser Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala 
                405                 410                 415     


Leu Arg Phe Pro Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe 
            420                 425                 430         


Tyr Phe Arg Thr Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly 
        435                 440                 445             


Gly Pro Phe Cys Arg Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn 
    450                 455                 460                 


Thr Ser Arg Asp Val Val Phe Ala Phe Asp Ile Gly Asn Gly Asp Glu 
465                 470                 475                 480 


Asn Leu Thr Val His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp 
                485                 490                 495     


His Leu Val Arg Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val 
            500                 505                 510         


Asp His Arg Pro Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile 
        515                 520                 525             


Trp Leu Val Tyr Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys 
    530                 535                 540                 


Arg Arg Pro Phe Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val 
545                 550                 555                 560 


Thr Leu Asn Leu Glu Gly Arg 
                565         


<210>  40
<211>  1384
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                565                 570                 575     


His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
        675                 680                 685             


Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
    690                 695                 700                 


Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
705                 710                 715                 720 


Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                725                 730                 735     


Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
            740                 745                 750         


Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
        755                 760                 765             


Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
    770                 775                 780                 


Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
785                 790                 795                 800 


Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                805                 810                 815     


Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
            820                 825                 830         


Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
        835                 840                 845             


Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
    850                 855                 860                 


Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
865                 870                 875                 880 


Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                885                 890                 895     


Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
            900                 905                 910         


Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
        915                 920                 925             


Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
    930                 935                 940                 


Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His 
945                 950                 955                 960 


Cys Ala His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu 
                965                 970                 975     


Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly 
            980                 985                 990         


Pro Tyr Cys Asn His Asp Ile Gly  Gly Phe Phe Glu Pro  Gly Thr Trp 
        995                 1000                 1005             


Met Arg  Tyr Asn Leu Gln Ser  Ala Leu Arg Ser Ala  Ala Arg Glu 
    1010                 1015                 1020             


Phe Ser  His Met Leu Ser Arg  Pro Val Pro Gly Tyr  Glu Pro Gly 
    1025                 1030                 1035             


Tyr Ile  Pro Gly Tyr Asp Thr  Pro Gly Tyr Val Pro  Gly Tyr His 
    1040                 1045                 1050             


Gly Pro  Gly Tyr Arg Leu Pro  Asp Tyr Pro Arg Pro  Gly Arg Pro 
    1055                 1060                 1065             


Val Pro  Gly Tyr Arg Gly Pro  Val Tyr Asn Val Thr  Gly Glu Glu 
    1070                 1075                 1080             


Val Ser  Phe Ser Phe Ser Thr  Ser Ser Ala Pro Ala  Val Leu Leu 
    1085                 1090                 1095             


Tyr Val  Ser Ser Phe Val Arg  Asp Tyr Met Ala Val  Leu Ile Lys 
    1100                 1105                 1110             


Asp Asp  Gly Thr Leu Gln Leu  Arg Tyr Gln Leu Gly  Thr Ser Pro 
    1115                 1120                 1125             


Tyr Val  Tyr Gln Leu Thr Thr  Arg Pro Val Thr Asp  Gly Gln Pro 
    1130                 1135                 1140             


His Ser  Ile Asn Ile Thr Arg  Val Tyr Arg Asn Leu  Phe Ile Gln 
    1145                 1150                 1155             


Val Asp  Tyr Phe Pro Leu Thr  Glu Gln Lys Phe Ser  Leu Leu Val 
    1160                 1165                 1170             


Asp Ser  Gln Leu Asp Ser Pro  Lys Ala Leu Tyr Leu  Gly Arg Val 
    1175                 1180                 1185             


Met Glu  Thr Gly Val Ile Asp  Pro Glu Ile Gln Arg  Tyr Asn Thr 
    1190                 1195                 1200             


Pro Gly  Phe Ser Gly Cys Leu  Ser Gly Val Arg Phe  Asn Asn Val 
    1205                 1210                 1215             


Ala Pro  Leu Lys Thr His Phe  Arg Thr Pro Arg Pro  Met Thr Ala 
    1220                 1225                 1230             


Glu Leu  Ala Glu Ala Leu Arg  Val Gln Gly Glu Leu  Ser Glu Ser 
    1235                 1240                 1245             


Asn Cys  Gly Ala Met Pro Arg  Leu Val Ser Glu Val  Pro Pro Glu 
    1250                 1255                 1260             


Leu Asp  Pro Trp Tyr Leu Pro  Pro Asp Phe Pro Tyr  Tyr His Asp 
    1265                 1270                 1275             


Glu Gly  Trp Val Ala Ile Leu  Leu Gly Phe Leu Val  Ala Phe Leu 
    1280                 1285                 1290             


Leu Leu  Gly Leu Val Gly Met  Leu Val Leu Phe Tyr  Leu Gln Asn 
    1295                 1300                 1305             


His Arg  Tyr Lys Gly Ser Tyr  His Thr Asn Glu Pro  Lys Ala Ala 
    1310                 1315                 1320             


His Glu  Tyr His Pro Gly Ser  Lys Pro Pro Leu Pro  Thr Ser Gly 
    1325                 1330                 1335             


Pro Ala  Gln Val Pro Thr Pro  Thr Ala Ala Pro Asn  Gln Ala Pro 
    1340                 1345                 1350             


Ala Ser  Ala Pro Ala Pro Ala  Pro Thr Pro Ala Pro  Ala Pro Gly 
    1355                 1360                 1365             


Pro Arg  Asp Gln Asn Leu Pro  Gln Ile Leu Glu Glu  Ser Arg Ser 
    1370                 1375                 1380             


Glu 
    


<210>  41
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg 
    370                 375                 


<210>  42
<211>  1005
<212>  PRT
<213>  Homo sapiens

<400>  42

Arg Gly Arg Leu Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr 
1               5                   10                  15      


Gly Leu Leu Leu Phe Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu 
            20                  25                  30          


Leu Thr Leu Ser Glu Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly 
        35                  40                  45              


Arg Lys Lys Leu Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe 
    50                  55                  60                  


Trp His Glu Val Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser 
65                  70                  75                  80  


Ile Asp Asp Val Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu 
                85                  90                  95      


Ile Arg Thr Gly Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala 
            100                 105                 110         


Ser Arg Trp Asp Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met 
        115                 120                 125             


Glu Leu Leu Lys Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu 
    130                 135                 140                 


Gly Arg Arg Leu Gly Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly 
145                 150                 155                 160 


Ile Thr Asp Arg Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys 
                165                 170                 175     


Tyr Gln Ser Trp Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr 
            180                 185                 190         


Lys Gly Glu Thr Cys His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala 
        195                 200                 205             


Tyr Arg Leu Ser Gly Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp 
    210                 215                 220                 


Gly Ser Gly Pro Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu 
225                 230                 235                 240 


Asn Arg Ala Trp Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg 
                245                 250                 255     


Val Thr Gly Ser Ser Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr 
            260                 265                 270         


Trp Asn Ala Ser Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln 
        275                 280                 285             


His Cys Glu Gln Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu 
    290                 295                 300                 


Asn Thr Ala Gly Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu 
305                 310                 315                 320 


Glu Gln His Phe Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys 
                325                 330                 335     


Ala Cys Gly Leu Asp Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn 
            340                 345                 350         


Cys Asp Ala Asp Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr 
        355                 360                 365             


Phe Val Asp His Leu Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn 
    370                 375                 380                 


Arg Ser Thr Ser Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr 
385                 390                 395                 400 


Gly Asp Arg Asn Ser Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala 
                405                 410                 415     


Leu Arg Phe Pro Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe 
            420                 425                 430         


Tyr Phe Arg Thr Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly 
        435                 440                 445             


Gly Pro Tyr Cys Gln Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn 
    450                 455                 460                 


Thr Ser Arg Asp Val Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu 
465                 470                 475                 480 


Asn Leu Thr Val His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp 
                485                 490                 495     


His Leu Val Arg Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val 
            500                 505                 510         


Asp His Arg Pro Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile 
        515                 520                 525             


Trp Met Glu Tyr Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys 
    530                 535                 540                 


Arg Arg Pro Phe Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val 
545                 550                 555                 560 


Thr Leu Asn Leu Glu Gly Arg Ala Asn Ala Ser Glu Gly Thr Ser Pro 
                565                 570                 575     


Asn Cys Thr Gly His Cys Ala His Pro Arg Leu Pro Cys Phe His Gly 
            580                 585                 590         


Gly Arg Cys Val Glu Arg Tyr Ser Tyr Tyr Thr Cys Asp Cys Asp Leu 
        595                 600                 605             


Thr Ala Phe Asp Gly Pro Tyr Cys Asn His Asp Ile Gly Gly Phe Phe 
    610                 615                 620                 


Glu Pro Gly Thr Trp Met Arg Tyr Asn Leu Gln Ser Ala Leu Arg Ser 
625                 630                 635                 640 


Ala Ala Arg Glu Phe Ser His Met Leu Ser Arg Pro Val Pro Gly Tyr 
                645                 650                 655     


Glu Pro Gly Tyr Ile Pro Gly Tyr Asp Thr Pro Gly Tyr Val Pro Gly 
            660                 665                 670         


Tyr His Gly Pro Gly Tyr Arg Leu Pro Asp Tyr Pro Arg Pro Gly Arg 
        675                 680                 685             


Pro Val Pro Gly Tyr Arg Gly Pro Val Tyr Asn Val Thr Gly Glu Glu 
    690                 695                 700                 


Val Ser Phe Ser Phe Ser Thr Ser Ser Ala Pro Ala Val Leu Leu Tyr 
705                 710                 715                 720 


Val Ser Ser Phe Val Arg Asp Tyr Met Ala Val Leu Ile Lys Asp Asp 
                725                 730                 735     


Gly Thr Leu Gln Leu Arg Tyr Gln Leu Gly Thr Ser Pro Tyr Val Tyr 
            740                 745                 750         


Gln Leu Thr Thr Arg Pro Val Thr Asp Gly Gln Pro His Ser Ile Asn 
        755                 760                 765             


Ile Thr Arg Val Tyr Arg Asn Leu Phe Ile Gln Val Asp Tyr Phe Pro 
    770                 775                 780                 


Leu Thr Glu Gln Lys Phe Ser Leu Leu Val Asp Ser Gln Leu Asp Ser 
785                 790                 795                 800 


Pro Lys Ala Leu Tyr Leu Gly Arg Val Met Glu Thr Gly Val Ile Asp 
                805                 810                 815     


Pro Glu Ile Gln Arg Tyr Asn Thr Pro Gly Phe Ser Gly Cys Leu Ser 
            820                 825                 830         


Gly Val Arg Phe Asn Asn Val Ala Pro Leu Lys Thr His Phe Arg Thr 
        835                 840                 845             


Pro Arg Pro Met Thr Ala Glu Leu Ala Glu Ala Leu Arg Val Gln Gly 
    850                 855                 860                 


Glu Leu Ser Glu Ser Asn Cys Gly Ala Met Pro Arg Leu Val Ser Glu 
865                 870                 875                 880 


Val Pro Pro Glu Leu Asp Pro Trp Tyr Leu Pro Pro Asp Phe Pro Tyr 
                885                 890                 895     


Tyr His Asp Glu Gly Trp Val Ala Ile Leu Leu Gly Phe Leu Val Ala 
            900                 905                 910         


Phe Leu Leu Leu Gly Leu Val Gly Met Leu Val Leu Phe Tyr Leu Gln 
        915                 920                 925             


Asn His Arg Tyr Lys Gly Ser Tyr His Thr Asn Glu Pro Lys Ala Ala 
    930                 935                 940                 


His Glu Tyr His Pro Gly Ser Lys Pro Pro Leu Pro Thr Ser Gly Pro 
945                 950                 955                 960 


Ala Gln Val Pro Thr Pro Thr Ala Ala Pro Asn Gln Ala Pro Ala Ser 
                965                 970                 975     


Ala Pro Ala Pro Ala Pro Thr Pro Ala Pro Ala Pro Gly Pro Arg Asp 
            980                 985                 990         


Gln Asn Leu Pro Gln Ile Leu Glu  Glu Ser Arg Ser Glu  
        995                 1000                 1005 


<210>  43
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Met His Leu Arg Leu Phe Cys Ile Leu Leu Ala Ala Val Ser Gly 
1               5                   10                  15      


Ala Glu Gly Trp Gly Tyr Tyr Gly Cys Asp Glu Glu Leu Val Gly Pro 
            20                  25                  30          


Leu Tyr Ala Arg Ser Leu Gly Ala Ser Ser Tyr Tyr Ser Leu Leu Thr 
        35                  40                  45              


Ala Pro Arg Phe Ala Arg Leu His Gly Ile Ser Gly Trp Ser Pro Arg 
    50                  55                  60                  


Ile Gly Asp Pro Asn Pro Trp Leu Gln Ile Asp Leu Met Lys Lys His 
65                  70                  75                  80  


Arg Ile Arg Ala Val Ala Thr Gln Gly Ser Phe Asn Ser Trp Asp Trp 
                85                  90                  95      


Val Thr Arg Tyr Met Leu Leu Tyr Gly Asp Arg Val Asp Ser Trp Thr 
            100                 105                 110         


Pro Phe Tyr Gln Arg Gly His Asn Ser Thr Phe Phe Gly Asn Val Asn 
        115                 120                 125             


Glu Ser Ala Val Val Arg His Asp Leu His Phe His Phe Thr Ala Arg 
    130                 135                 140                 


Tyr Ile Arg Ile Val Pro Leu Ala Trp Asn Pro Arg Gly Lys Ile Gly 
145                 150                 155                 160 


Leu Arg Leu Gly Leu Tyr Gly Cys Pro Tyr Lys Ala Asp Ile Leu Tyr 
                165                 170                 175     


Phe Asp Gly Asp Asp Ala Ile Ser Tyr Arg Phe Pro Arg Gly Val Ser 
            180                 185                 190         


Arg Ser Leu Trp Asp Val Phe Ala Phe Ser Phe Lys Thr Glu Glu Lys 
        195                 200                 205             


Asp Gly Leu Leu Leu His Ala Glu Gly Ala Gln Gly Asp Tyr Val Thr 
    210                 215                 220                 


Leu Glu Leu Glu Gly Ala His Leu Leu Leu His Met Ser Leu Gly Ser 
225                 230                 235                 240 


Ser Pro Ile Gln Pro Arg Pro Gly His Thr Thr Val Ser Ala Gly Gly 
                245                 250                 255     


Val Leu Asn Asp Gln His Trp His Tyr Val Arg Val Asp Arg Phe Gly 
            260                 265                 270         


Arg Asp Val Asn Phe Thr Leu Asp Gly Tyr Val Gln Arg Phe Ile Leu 
        275                 280                 285             


Asn Gly Asp Phe Glu Arg Leu Asn Leu Asp Thr Glu Met Phe Ile Gly 
    290                 295                 300                 


Gly Leu Val Gly Ala Ala Arg Lys Asn Leu Ala Tyr Arg His Asn Phe 
305                 310                 315                 320 


Arg Gly Cys Ile Glu Asn Val Ile Phe Asn Arg Val Asn Ile Ala Asp 
                325                 330                 335     


Leu Ala Val Arg Arg His Ser Arg Ile Thr Phe Glu Gly Lys Val Ala 
            340                 345                 350         


Phe Arg Cys Leu Asp Pro Val Pro His Pro Ile Asn Phe Gly Gly Pro 
        355                 360                 365             


His Asn Phe Val Gln Val Pro Gly Phe Pro Arg Arg Gly Arg Leu Ala 
    370                 375                 380                 


Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr Gly Leu Leu Leu Phe 
385                 390                 395                 400 


Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu Leu Thr Leu Ser Glu 
                405                 410                 415     


Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly Arg Lys Lys Leu Gln 
            420                 425                 430         


Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe Trp His Glu Val Asn 
        435                 440                 445             


Phe Val Ala Gln Glu Asn His Ala Val Ile Ser Ile Asp Asp Val Glu 
    450                 455                 460                 


Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu Ile Arg Thr Gly Thr 
465                 470                 475                 480 


Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala Ser Arg Trp Asp Cys 
                485                 490                 495     


His Ser Asn Gln Thr Ala Phe His Gly Cys Met Glu Leu Leu Lys Val 
            500                 505                 510         


Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu Gly Arg Arg Leu Gly 
        515                 520                 525             


Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly Ile Thr Asp Arg Cys 
    530                 535                 540                 


Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys Tyr Gln Ser Trp Asp 
545                 550                 555                 560 


Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr Lys Gly Glu Thr Cys 
                565                 570                 575     


His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala Tyr Arg Leu Ser Gly 
            580                 585                 590         


Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp Gly Ser Gly Pro Leu 
        595                 600                 605             


Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu Asn Arg Ala Trp Thr 
    610                 615                 620                 


Val Val Arg His Asp Arg Leu Trp Thr Thr Arg Val Thr Gly Ser Ser 
625                 630                 635                 640 


Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr Trp Asn Ala Ser Trp 
                645                 650                 655     


Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln His Cys Glu Gln Trp 
            660                 665                 670         


Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu Asn Thr Ala Gly Gly 
        675                 680                 685             


Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu Glu Gln His Phe Tyr 
    690                 695                 700                 


Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys Ala Cys Gly Leu Asp 
705                 710                 715                 720 


Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn Cys Asp Ala Asp Gln 
                725                 730                 735     


Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr Phe Val Asp His Leu 
            740                 745                 750         


Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn Arg Ser Thr Ser Glu 
        755                 760                 765             


Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr Gly Asp Arg Asn Ser 
    770                 775                 780                 


Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala Leu Arg Phe Pro Pro 
785                 790                 795                 800 


Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe Tyr Phe Arg Thr Ser 
                805                 810                 815     


Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly Gly Pro Tyr Cys Gln 
            820                 825                 830         


Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn Thr Ser Arg Asp Val 
        835                 840                 845             


Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu Asn Leu Thr Val His 
    850                 855                 860                 


Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp His Leu Val Arg Ala 
865                 870                 875                 880 


Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val Asp His Arg Pro Trp 
                885                 890                 895     


Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile Trp Met Glu Tyr Asp 
            900                 905                 910         


Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys Arg Arg Pro Phe Val 
        915                 920                 925             


Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val Thr Leu Asn Leu Glu 
    930                 935                 940                 


Gly Arg 
945     


<210>  44
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  44

Ala Asn Ala Ser Glu Gly Thr Ser Pro Asn Cys Thr Gly His Cys Ala 
1               5                   10                  15      


His Pro Arg Leu Pro Cys Phe His Gly Gly Arg Cys Val Glu Arg Tyr 
            20                  25                  30          


Ser Tyr Tyr Thr Cys Asp Cys Asp Leu Thr Ala Phe Asp Gly Pro Tyr 
        35                  40                  45              


Cys Asn His Asp Ile Gly Gly Phe Phe Glu Pro Gly Thr Trp Met Arg 
    50                  55                  60                  


Tyr Asn Leu Gln Ser Ala Leu Arg Ser Ala Ala Arg Glu Phe Ser His 
65                  70                  75                  80  


Met Leu Ser Arg Pro Val Pro Gly Tyr Glu Pro Gly Tyr Ile Pro Gly 
                85                  90                  95      


Tyr Asp Thr Pro Gly Tyr Val Pro Gly Tyr His Gly Pro Gly Tyr Arg 
            100                 105                 110         


Leu Pro Asp Tyr Pro Arg Pro Gly Arg Pro Val Pro Gly Tyr Arg Gly 
        115                 120                 125             


Pro Val Tyr Asn Val Thr Gly Glu Glu Val Ser Phe Ser Phe Ser Thr 
    130                 135                 140                 


Ser Ser Ala Pro Ala Val Leu Leu Tyr Val Ser Ser Phe Val Arg Asp 
145                 150                 155                 160 


Tyr Met Ala Val Leu Ile Lys Asp Asp Gly Thr Leu Gln Leu Arg Tyr 
                165                 170                 175     


Gln Leu Gly Thr Ser Pro Tyr Val Tyr Gln Leu Thr Thr Arg Pro Val 
            180                 185                 190         


Thr Asp Gly Gln Pro His Ser Ile Asn Ile Thr Arg Val Tyr Arg Asn 
        195                 200                 205             


Leu Phe Ile Gln Val Asp Tyr Phe Pro Leu Thr Glu Gln Lys Phe Ser 
    210                 215                 220                 


Leu Leu Val Asp Ser Gln Leu Asp Ser Pro Lys Ala Leu Tyr Leu Gly 
225                 230                 235                 240 


Arg Val Met Glu Thr Gly Val Ile Asp Pro Glu Ile Gln Arg Tyr Asn 
                245                 250                 255     


Thr Pro Gly Phe Ser Gly Cys Leu Ser Gly Val Arg Phe Asn Asn Val 
            260                 265                 270         


Ala Pro Leu Lys Thr His Phe Arg Thr Pro Arg Pro Met Thr Ala Glu 
        275                 280                 285             


Leu Ala Glu Ala Leu Arg Val Gln Gly Glu Leu Ser Glu Ser Asn Cys 
    290                 295                 300                 


Gly Ala Met Pro Arg Leu Val Ser Glu Val Pro Pro Glu Leu Asp Pro 
305                 310                 315                 320 


Trp Tyr Leu Pro Pro Asp Phe Pro Tyr Tyr His Asp Glu Gly Trp Val 
                325                 330                 335     


Ala Ile Leu Leu Gly Phe Leu Val Ala Phe Leu Leu Leu Gly Leu Val 
            340                 345                 350         


Gly Met Leu Val Leu Phe Tyr Leu Gln Asn His Arg Tyr Lys Gly Ser 
        355                 360                 365             


Tyr His Thr Asn Glu Pro Lys Ala Ala His Glu Tyr His Pro Gly Ser 
    370                 375                 380                 


Lys Pro Pro Leu Pro Thr Ser Gly Pro Ala Gln Val Pro Thr Pro Thr 
385                 390                 395                 400 


Ala Ala Pro Asn Gln Ala Pro Ala Ser Ala Pro Ala Pro Ala Pro Thr 
                405                 410                 415     


Pro Ala Pro Ala Pro Gly Pro Arg Asp Gln Asn Leu Pro Gln Ile Leu 
            420                 425                 430         


Glu Glu Ser Arg Ser Glu 
        435             


<210>  45
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  45

Arg Gly Arg Leu Ala Val Ser Phe Arg Phe Arg Thr Trp Asp Leu Thr 
1               5                   10                  15      


Gly Leu Leu Leu Phe Ser Arg Leu Gly Asp Gly Leu Gly His Val Glu 
            20                  25                  30          


Leu Thr Leu Ser Glu Gly Gln Val Asn Val Ser Ile Ala Gln Ser Gly 
        35                  40                  45              


Arg Lys Lys Leu Gln Phe Ala Ala Gly Tyr Arg Leu Asn Asp Gly Phe 
    50                  55                  60                  


Trp His Glu Val Asn Phe Val Ala Gln Glu Asn His Ala Val Ile Ser 
65                  70                  75                  80  


Ile Asp Asp Val Glu Gly Ala Glu Val Arg Val Ser Tyr Pro Leu Leu 
                85                  90                  95      


Ile Arg Thr Gly Thr Ser Tyr Phe Phe Gly Gly Cys Pro Lys Pro Ala 
            100                 105                 110         


Ser Arg Trp Asp Cys His Ser Asn Gln Thr Ala Phe His Gly Cys Met 
        115                 120                 125             


Glu Leu Leu Lys Val Asp Gly Gln Leu Val Asn Leu Thr Leu Val Glu 
    130                 135                 140                 


Gly Arg Arg Leu Gly Phe Tyr Ala Glu Val Leu Phe Asp Thr Cys Gly 
145                 150                 155                 160 


Ile Thr Asp Arg Cys Ser Pro Asn Met Cys Glu His Asp Gly Arg Cys 
                165                 170                 175     


Tyr Gln Ser Trp Asp Asp Phe Ile Cys Tyr Cys Glu Leu Thr Gly Tyr 
            180                 185                 190         


Lys Gly Glu Thr Cys His Thr Pro Leu Tyr Lys Glu Ser Cys Glu Ala 
        195                 200                 205             


Tyr Arg Leu Ser Gly Lys Thr Ser Gly Asn Phe Thr Ile Asp Pro Asp 
    210                 215                 220                 


Gly Ser Gly Pro Leu Lys Pro Phe Val Val Tyr Cys Asp Ile Arg Glu 
225                 230                 235                 240 


Asn Arg Ala Trp Thr Val Val Arg His Asp Arg Leu Trp Thr Thr Arg 
                245                 250                 255     


Val Thr Gly Ser Ser Met Glu Arg Pro Phe Leu Gly Ala Ile Gln Tyr 
            260                 265                 270         


Trp Asn Ala Ser Trp Glu Glu Val Ser Ala Leu Ala Asn Ala Ser Gln 
        275                 280                 285             


His Cys Glu Gln Trp Ile Glu Phe Ser Cys Tyr Asn Ser Arg Leu Leu 
    290                 295                 300                 


Asn Thr Ala Gly Gly Tyr Pro Tyr Ser Phe Trp Ile Gly Arg Asn Glu 
305                 310                 315                 320 


Glu Gln His Phe Tyr Trp Gly Gly Ser Gln Pro Gly Ile Gln Arg Cys 
                325                 330                 335     


Ala Cys Gly Leu Asp Arg Ser Cys Val Asp Pro Ala Leu Tyr Cys Asn 
            340                 345                 350         


Cys Asp Ala Asp Gln Pro Gln Trp Arg Thr Asp Lys Gly Leu Leu Thr 
        355                 360                 365             


Phe Val Asp His Leu Pro Val Thr Gln Val Val Ile Gly Asp Thr Asn 
    370                 375                 380                 


Arg Ser Thr Ser Glu Ala Gln Phe Phe Leu Arg Pro Leu Arg Cys Tyr 
385                 390                 395                 400 


Gly Asp Arg Asn Ser Trp Asn Thr Ile Ser Phe His Thr Gly Ala Ala 
                405                 410                 415     


Leu Arg Phe Pro Pro Ile Arg Ala Asn His Ser Leu Asp Val Ser Phe 
            420                 425                 430         


Tyr Phe Arg Thr Ser Ala Pro Ser Gly Val Phe Leu Glu Asn Met Gly 
        435                 440                 445             


Gly Pro Tyr Cys Gln Trp Arg Arg Pro Tyr Val Arg Val Glu Leu Asn 
    450                 455                 460                 


Thr Ser Arg Asp Val Val Phe Ala Phe Asp Val Gly Asn Gly Asp Glu 
465                 470                 475                 480 


Asn Leu Thr Val His Ser Asp Asp Phe Glu Phe Asn Asp Asp Glu Trp 
                485                 490                 495     


His Leu Val Arg Ala Glu Ile Asn Val Lys Gln Ala Arg Leu Arg Val 
            500                 505                 510         


Asp His Arg Pro Trp Val Leu Arg Pro Met Pro Leu Gln Thr Tyr Ile 
        515                 520                 525             


Trp Met Glu Tyr Asp Gln Pro Leu Tyr Val Gly Ser Ala Glu Leu Lys 
    530                 535                 540                 


Arg Arg Pro Phe Val Gly Cys Leu Arg Ala Met Arg Leu Asn Gly Val 
545                 550                 555                 560 


Thr Leu Asn Leu Glu Gly Arg 
                565         


