                         SEQUENCE LISTING

<110>  SynAffix B.V.
 
<120>  Process for the modification of a glycoprotein using a 
       glycosyltransferase that is or is derived from a  
       -(1,4)-N-acetylgalactosaminyltransferase

<130>  P6055617PCT

<150>  EP15164864.9
<151>  2015-04-23

<160>  92    

<170>  PatentIn version 3.3

<210>  1
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Bos Taurus GalT Y289L mutant

<400>  1

Met Lys Phe Arg Glu Pro Leu Leu Gly Gly Ser Ala Ala Met Pro Gly 
1               5                   10                  15      


Ala Ser Leu Gln Arg Ala Cys Arg Leu Leu Val Ala Val Cys Ala Leu 
            20                  25                  30          


His Leu Gly Val Thr Leu Val Tyr Tyr Leu Ala Gly Arg Asp Leu Arg 
        35                  40                  45              


Arg Leu Pro Gln Leu Val Gly Val His Pro Pro Leu Gln Gly Ser Ser 
    50                  55                  60                  


His Gly Ala Ala Ala Ile Gly Gln Pro Ser Gly Glu Leu Arg Leu Arg 
65                  70                  75                  80  


Gly Val Ala Pro Pro Pro Pro Leu Gln Asn Ser Ser Lys Pro Arg Ser 
                85                  90                  95      


Arg Ala Pro Ser Asn Leu Asp Ala Tyr Ser His Pro Gly Pro Gly Pro 
            100                 105                 110         


Gly Pro Gly Ser Asn Leu Thr Ser Ala Pro Val Pro Ser Thr Thr Thr 
        115                 120                 125             


Arg Ser Leu Thr Ala Cys Pro Glu Glu Ser Pro Leu Leu Val Gly Pro 
    130                 135                 140                 


Met Leu Ile Glu Phe Asn Ile Pro Val Asp Leu Lys Leu Ile Glu Gln 
145                 150                 155                 160 


Gln Asn Pro Lys Val Lys Leu Gly Gly Arg Tyr Thr Pro Met Asp Cys 
                165                 170                 175     


Ile Ser Pro His Lys Val Ala Ile Ile Ile Leu Phe Arg Asn Arg Gln 
            180                 185                 190         


Glu His Leu Lys Tyr Trp Leu Tyr Tyr Leu His Pro Met Val Gln Arg 
        195                 200                 205             


Gln Gln Leu Asp Tyr Gly Ile Tyr Val Ile Asn Gln Ala Gly Glu Ser 
    210                 215                 220                 


Met Phe Asn Arg Ala Lys Leu Leu Asn Val Gly Phe Lys Glu Ala Leu 
225                 230                 235                 240 


Lys Asp Tyr Asp Tyr Asn Cys Phe Val Phe Ser Asp Val Asp Leu Ile 
                245                 250                 255     


Pro Met Asn Asp His Asn Thr Tyr Arg Cys Phe Ser Gln Pro Arg His 
            260                 265                 270         


Ile Ser Val Ala Met Asp Lys Phe Gly Phe Ser Leu Pro Tyr Val Gln 
        275                 280                 285             


Leu Phe Gly Gly Val Ser Ala Leu Ser Lys Gln Gln Phe Leu Ser Ile 
    290                 295                 300                 


Asn Gly Phe Pro Asn Asn Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
305                 310                 315                 320 


Ile Tyr Asn Arg Leu Ala Phe Arg Gly Met Ser Val Ser Arg Pro Asn 
                325                 330                 335     


Ala Val Ile Gly Lys Cys Arg Met Ile Arg His Ser Arg Asp Lys Lys 
            340                 345                 350         


Asn Glu Pro Asn Pro Gln Arg Phe Asp Arg Ile Ala His Thr Lys Glu 
        355                 360                 365             


Thr Met Leu Ser Asp Gly Leu Asn Ser Leu Thr Tyr Met Val Leu Glu 
    370                 375                 380                 


Val Gln Arg Tyr Pro Leu Tyr Thr Lys Ile Thr Val Asp Ile Gly Thr 
385                 390                 395                 400 


Pro Ser 
        


<210>  2
<211>  383
<212>  PRT
<213>  Caenorhabditis elegans

<400>  2

Met Ala Phe Arg His Leu Ala Val Ala Arg Leu Lys Ser Leu Leu Val 
1               5                   10                  15      


Leu Cys Ala Val Leu Leu Leu Val His Ala Met Ile Tyr Lys Ile Pro 
            20                  25                  30          


Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu Ile Ala Asp 
        35                  40                  45              


Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser Thr Ser Asp 
    50                  55                  60                  


Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile Ser Glu Val 
65                  70                  75                  80  


Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu Phe Pro Asp 
                85                  90                  95      


Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His Leu Val Gly 
            100                 105                 110         


Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr Leu Glu Lys 
        115                 120                 125             


Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro Lys Asp Cys 
    130                 135                 140                 


Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg Asp Arg Glu 
145                 150                 155                 160 


Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu Leu Ala Lys 
                165                 170                 175     


Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val Ala Asn Gln 
            180                 185                 190         


Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp Val Ala Ser 
        195                 200                 205             


Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val Asp Leu Leu 
    210                 215                 220                 


Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln Pro Arg His 
225                 230                 235                 240 


Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro Tyr Ser Ala 
                245                 250                 255     


Ile Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu Lys Lys Ile 
            260                 265                 270         


Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp 
        275                 280                 285             


Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser Arg Tyr Pro 
    290                 295                 300                 


Thr Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln Thr Lys Arg 
                325                 330                 335     


Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys Leu Val Asn 
            340                 345                 350         


Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp Leu Leu Glu 
        355                 360                 365             


Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr Cys Phe 
    370                 375                 380             


<210>  3
<211>  383
<212>  PRT
<213>  Ascaris suum

<400>  3

Met Asn Ser Lys Leu Lys Leu Val Ile Val Leu Thr Leu Cys Val Ala 
1               5                   10                  15      


Ile Ile His Phe Leu Leu Ser Asp Cys Pro Ile Ser Pro Asp Tyr Ser 
            20                  25                  30          


Phe Trp Ser Pro Ala Phe Ile Ile Ser Ala Pro Lys Thr Leu Thr Thr 
        35                  40                  45              


Leu Gln Pro Phe Ser Gln Ser Thr Ser Thr Asn Asp Leu Ala Val Ser 
    50                  55                  60                  


Ala Leu Glu Ser Val Glu Phe Ser Met Leu Asp Asn Ser Ser Ile Leu 
65                  70                  75                  80  


His Ala Ser Asp Asn Trp Thr Asn Asp Glu Leu Val Met Arg Ala Gln 
                85                  90                  95      


Asn Glu Asn Leu Gln Leu Cys Pro Met Thr Pro Pro Ala Leu Val Gly 
            100                 105                 110         


Pro Ile Lys Val Trp Met Asp Ala Pro Ser Phe Ala Glu Leu Glu Arg 
        115                 120                 125             


Leu Tyr Pro Phe Leu Glu Pro Gly Gly His Gly Met Pro Thr Ala Cys 
    130                 135                 140                 


Arg Ala Arg His Arg Val Ala Ile Val Val Pro Tyr Arg Asp Arg Glu 
145                 150                 155                 160 


Ser His Leu Arg Thr Phe Leu His Asn Leu His Ser Leu Leu Thr Lys 
                165                 170                 175     


Gln Gln Leu Asp Tyr Ala Ile Phe Val Val Glu Gln Thr Ala Asn Glu 
            180                 185                 190         


Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr Ala Glu Ala Ile 
        195                 200                 205             


Arg Leu Tyr Asp Trp Arg Cys Phe Ile Phe His Asp Val Asp Leu Leu 
    210                 215                 220                 


Pro Glu Asp Asp Arg Asn Leu Tyr Ser Cys Pro Asp Glu Pro Arg His 
225                 230                 235                 240 


Met Ser Val Ala Val Asp Lys Phe Asn Tyr Lys Leu Pro Tyr Gly Ser 
                245                 250                 255     


Ile Phe Gly Gly Ile Ser Ala Leu Thr Arg Glu Gln Phe Glu Gly Ile 
            260                 265                 270         


Asn Gly Phe Ser Asn Asp Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp 
        275                 280                 285             


Leu Ser Thr Arg Val Thr Leu Ala Gly Tyr Lys Ile Ser Arg Tyr Pro 
    290                 295                 300                 


Ala Glu Ile Ala Arg Tyr Lys Met Ile Lys His Asn Ser Glu Lys Lys 
305                 310                 315                 320 


Asn Pro Val Asn Arg Cys Arg Tyr Lys Leu Met Ser Ala Thr Lys Ser 
                325                 330                 335     


Arg Trp Arg Asn Asp Gly Leu Ser Ser Leu Ser Tyr Asp Leu Ile Ser 
            340                 345                 350         


Leu Gly Arg Leu Pro Leu Tyr Thr His Ile Lys Val Asp Leu Leu Glu 
        355                 360                 365             


Lys Gln Ser Arg Arg Tyr Leu Arg Thr His Gly Phe Pro Thr Cys 
    370                 375                 380             


<210>  4
<211>  421
<212>  PRT
<213>  Trichoplusia ni

<400>  4

Met Gly Gly Arg Ala Thr Arg Ala Leu Arg Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Ala Leu Ala Ala Val Glu Tyr Leu Phe Gly Ser Ile Leu Asp Ala 
            20                  25                  30          


Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
        35                  40                  45              


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
    50                  55                  60                  


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
65                  70                  75                  80  


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
                85                  90                  95      


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
            100                 105                 110         


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
        115                 120                 125             


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
    130                 135                 140                 


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
145                 150                 155                 160 


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
                165                 170                 175     


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
            180                 185                 190         


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
        195                 200                 205             


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
    210                 215                 220                 


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
225                 230                 235                 240 


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
                245                 250                 255     


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
            260                 265                 270         


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
        275                 280                 285             


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
    290                 295                 300                 


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
305                 310                 315                 320 


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
                325                 330                 335     


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
            340                 345                 350         


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
        355                 360                 365             


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
    370                 375                 380                 


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
385                 390                 395                 400 


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
                405                 410                 415     


Ile Asp Glu Arg Ser 
            420     


<210>  5
<211>  403
<212>  PRT
<213>  Drosophila melanogaster

<400>  5

Met Tyr Leu Phe Thr Lys Ala Asn Leu Ile Arg Phe Leu Ala Gly Ala 
1               5                   10                  15      


Ile Cys Leu Leu Leu Val Leu Asn Phe Val Gly Phe Arg Ser Asp Gly 
            20                  25                  30          


Gly Ser Ala Thr Ser Leu Ser Lys Leu Ser Ile Arg Arg Val His Lys 
        35                  40                  45              


Tyr Ala His Ile Tyr Gly Asn Ala Ser Ser Asp Gly Ala Gly Gly Ser 
    50                  55                  60                  


Glu Ala Ser Arg Leu Pro Ala Ser Pro Leu Ala Leu Ser Lys Asp Arg 
65                  70                  75                  80  


Glu Arg Asp Gln Glu Leu Asn Gly Gly Pro Asn Ser Thr Ile Arg Thr 
                85                  90                  95      


Val Ile Ala Thr Ala Asn Phe Thr Ser Ile Pro Gln Asp Leu Thr Arg 
            100                 105                 110         


Phe Leu Leu Gly Thr Lys Lys Phe Leu Pro Pro Arg Gln Lys Ser Thr 
        115                 120                 125             


Ser Ala Leu Leu Ala Asn Cys Thr Asp Pro Asp Pro Arg Asp Gly Gly 
    130                 135                 140                 


Pro Ile Thr Pro Asn Thr Thr Leu Glu Ser Leu Asp Val Ile Glu Ala 
145                 150                 155                 160 


Glu Leu Gly Pro Leu Leu Arg Pro Gly Gly Ala Phe Glu Pro Glu Asn 
                165                 170                 175     


Cys Asn Ala Gln His His Val Ala Ile Val Val Pro Phe Arg Asp Arg 
            180                 185                 190         


Tyr Ala His Leu Leu Leu Phe Leu Arg Asn Ile His Pro Phe Leu Met 
        195                 200                 205             


Lys Gln Arg Ile Ala Tyr Arg Ile Phe Ile Val Glu Gln Thr Asn Gly 
    210                 215                 220                 


Lys Pro Phe Asn Arg Ala Ala Met Met Asn Ile Gly Tyr Leu Glu Ala 
225                 230                 235                 240 


Leu Lys Leu Tyr Gln Trp Asp Cys Phe Ile Phe His Asp Val Asp Leu 
                245                 250                 255     


Leu Pro Leu Asp Asp Arg Asn Leu Tyr Asn Cys Pro Arg Gln Pro Arg 
            260                 265                 270         


His Met Ser Val Ala Ile Asp Thr Leu Asn Phe Arg Leu Pro Tyr Arg 
        275                 280                 285             


Ser Ile Phe Gly Gly Val Ser Ala Met Thr Arg Glu His Phe Gln Ala 
    290                 295                 300                 


Val Asn Gly Phe Ser Asn Ser Phe Phe Gly Trp Gly Gly Glu Asp Asp 
305                 310                 315                 320 


Asp Met Ser Asn Arg Leu Lys His Ala Asn Leu Phe Ile Ser Arg Tyr 
                325                 330                 335     


Pro Val Asn Ile Ala Arg Tyr Lys Met Leu Lys His Gln Lys Glu Lys 
            340                 345                 350         


Ala Asn Pro Lys Arg Tyr Glu Asn Leu Gln Asn Gly Met Ser Lys Ile 
        355                 360                 365             


Glu Gln Asp Gly Ile Asn Ser Ile Lys Tyr Ser Ile Tyr Ser Ile Lys 
    370                 375                 380                 


Gln Phe Pro Thr Phe Thr Trp Tyr Leu Ala Glu Leu Lys Asn Ser Glu 
385                 390                 395                 400 


Arg Lys Ser 
            


<210>  6
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  CeGalNAcT(30-383)

<400>  6

Lys Ile Pro Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu 
1               5                   10                  15      


Ile Ala Asp Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Asp Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile 
        35                  40                  45              


Ser Glu Val Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu 
    50                  55                  60                  


Phe Pro Asp Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His 
65                  70                  75                  80  


Leu Val Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr 
                85                  90                  95      


Leu Glu Lys Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro 
            100                 105                 110         


Lys Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Ala Lys Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val 
145                 150                 155                 160 


Ala Asn Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp 
                165                 170                 175     


Val Ala Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Ser Ala Ile Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu 
225                 230                 235                 240 


Lys Lys Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser 
            260                 265                 270         


Arg Tyr Pro Thr Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr 
        275                 280                 285             


Glu Ala Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln 
    290                 295                 300                 


Thr Lys Arg Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys 
305                 310                 315                 320 


Leu Val Asn Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr 
            340                 345                 350         


Cys Phe 
        


<210>  7
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  AsGalNAcT (30-383)

<400>  7

Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile Ser Ala Pro Lys Thr 
1               5                   10                  15      


Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr Ser Thr Asn Asp Leu 
            20                  25                  30          


Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser Met Leu Asp Asn Ser 
        35                  40                  45              


Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn Asp Glu Leu Val Met 
    50                  55                  60                  


Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro Met Thr Pro Pro Ala 
65                  70                  75                  80  


Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala Pro Ser Phe Ala Glu 
                85                  90                  95      


Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly Gly His Gly Met Pro 
            100                 105                 110         


Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile Val Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ser His Leu Arg Thr Phe Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe Val Val Glu Gln Thr 
145                 150                 155                 160 


Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr Ala 
                165                 170                 175     


Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Ser Cys Pro Asp Glu 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Val Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Gly Ser Ile Phe Gly Gly Ile Ser Ala Leu Thr Arg Glu Gln Phe 
225                 230                 235                 240 


Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala Gly Tyr Lys Ile Ser 
            260                 265                 270         


Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met Ile Lys His Asn Ser 
        275                 280                 285             


Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr Lys Leu Met Ser Ala 
    290                 295                 300                 


Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser Ser Leu Ser Tyr Asp 
305                 310                 315                 320 


Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr His Ile Lys Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg Thr His Gly Phe Pro 
            340                 345                 350         


Thr Cys 
        


<210>  8
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421)

<400>  8

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  9
<211>  357
<212>  PRT
<213>  Artificial

<220>
<223>  DmGalNAcT (47-403)

<400>  9

His Lys Tyr Ala His Ile Tyr Gly Asn Ala Ser Ser Asp Gly Ala Gly 
1               5                   10                  15      


Gly Ser Glu Ala Ser Arg Leu Pro Ala Ser Pro Leu Ala Leu Ser Lys 
            20                  25                  30          


Asp Arg Glu Arg Asp Gln Glu Leu Asn Gly Gly Pro Asn Ser Thr Ile 
        35                  40                  45              


Arg Thr Val Ile Ala Thr Ala Asn Phe Thr Ser Ile Pro Gln Asp Leu 
    50                  55                  60                  


Thr Arg Phe Leu Leu Gly Thr Lys Lys Phe Leu Pro Pro Arg Gln Lys 
65                  70                  75                  80  


Ser Thr Ser Ala Leu Leu Ala Asn Cys Thr Asp Pro Asp Pro Arg Asp 
                85                  90                  95      


Gly Gly Pro Ile Thr Pro Asn Thr Thr Leu Glu Ser Leu Asp Val Ile 
            100                 105                 110         


Glu Ala Glu Leu Gly Pro Leu Leu Arg Pro Gly Gly Ala Phe Glu Pro 
        115                 120                 125             


Glu Asn Cys Asn Ala Gln His His Val Ala Ile Val Val Pro Phe Arg 
    130                 135                 140                 


Asp Arg Tyr Ala His Leu Leu Leu Phe Leu Arg Asn Ile His Pro Phe 
145                 150                 155                 160 


Leu Met Lys Gln Arg Ile Ala Tyr Arg Ile Phe Ile Val Glu Gln Thr 
                165                 170                 175     


Asn Gly Lys Pro Phe Asn Arg Ala Ala Met Met Asn Ile Gly Tyr Leu 
            180                 185                 190         


Glu Ala Leu Lys Leu Tyr Gln Trp Asp Cys Phe Ile Phe His Asp Val 
        195                 200                 205             


Asp Leu Leu Pro Leu Asp Asp Arg Asn Leu Tyr Asn Cys Pro Arg Gln 
    210                 215                 220                 


Pro Arg His Met Ser Val Ala Ile Asp Thr Leu Asn Phe Arg Leu Pro 
225                 230                 235                 240 


Tyr Arg Ser Ile Phe Gly Gly Val Ser Ala Met Thr Arg Glu His Phe 
                245                 250                 255     


Gln Ala Val Asn Gly Phe Ser Asn Ser Phe Phe Gly Trp Gly Gly Glu 
            260                 265                 270         


Asp Asp Asp Met Ser Asn Arg Leu Lys His Ala Asn Leu Phe Ile Ser 
        275                 280                 285             


Arg Tyr Pro Val Asn Ile Ala Arg Tyr Lys Met Leu Lys His Gln Lys 
    290                 295                 300                 


Glu Lys Ala Asn Pro Lys Arg Tyr Glu Asn Leu Gln Asn Gly Met Ser 
305                 310                 315                 320 


Lys Ile Glu Gln Asp Gly Ile Asn Ser Ile Lys Tyr Ser Ile Tyr Ser 
                325                 330                 335     


Ile Lys Gln Phe Pro Thr Phe Thr Trp Tyr Leu Ala Glu Leu Lys Asn 
            340                 345                 350         


Ser Glu Arg Lys Ser 
        355         


<210>  10
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  CeGalNacT(30-383; I257L)

<400>  10

Lys Ile Pro Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu 
1               5                   10                  15      


Ile Ala Asp Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Asp Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile 
        35                  40                  45              


Ser Glu Val Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu 
    50                  55                  60                  


Phe Pro Asp Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His 
65                  70                  75                  80  


Leu Val Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr 
                85                  90                  95      


Leu Glu Lys Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro 
            100                 105                 110         


Lys Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Ala Lys Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val 
145                 150                 155                 160 


Ala Asn Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp 
                165                 170                 175     


Val Ala Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Ser Ala Leu Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu 
225                 230                 235                 240 


Lys Lys Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser 
            260                 265                 270         


Arg Tyr Pro Thr Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr 
        275                 280                 285             


Glu Ala Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln 
    290                 295                 300                 


Thr Lys Arg Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys 
305                 310                 315                 320 


Leu Val Asn Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr 
            340                 345                 350         


Cys Phe 
        


<210>  11
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  CeGalNAcT(30-383; I257M)

<400>  11

Lys Ile Pro Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu 
1               5                   10                  15      


Ile Ala Asp Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Asp Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile 
        35                  40                  45              


Ser Glu Val Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu 
    50                  55                  60                  


Phe Pro Asp Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His 
65                  70                  75                  80  


Leu Val Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr 
                85                  90                  95      


Leu Glu Lys Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro 
            100                 105                 110         


Lys Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Ala Lys Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val 
145                 150                 155                 160 


Ala Asn Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp 
                165                 170                 175     


Val Ala Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Ser Ala Met Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu 
225                 230                 235                 240 


Lys Lys Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser 
            260                 265                 270         


Arg Tyr Pro Thr Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr 
        275                 280                 285             


Glu Ala Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln 
    290                 295                 300                 


Thr Lys Arg Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys 
305                 310                 315                 320 


Leu Val Asn Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr 
            340                 345                 350         


Cys Phe 
        


<210>  12
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  CeGalNacT(30-383; I257A)

<400>  12

Lys Ile Pro Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu 
1               5                   10                  15      


Ile Ala Asp Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Asp Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile 
        35                  40                  45              


Ser Glu Val Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu 
    50                  55                  60                  


Phe Pro Asp Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His 
65                  70                  75                  80  


Leu Val Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr 
                85                  90                  95      


Leu Glu Lys Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro 
            100                 105                 110         


Lys Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Ala Lys Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val 
145                 150                 155                 160 


Ala Asn Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp 
                165                 170                 175     


Val Ala Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Ser Ala Ala Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu 
225                 230                 235                 240 


Lys Lys Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser 
            260                 265                 270         


Arg Tyr Pro Thr Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr 
        275                 280                 285             


Glu Ala Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln 
    290                 295                 300                 


Thr Lys Arg Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys 
305                 310                 315                 320 


Leu Val Asn Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr 
            340                 345                 350         


Cys Phe 
        


<210>  13
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  CeGalNacT(30-383; M312H)

<400>  13

Lys Ile Pro Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu 
1               5                   10                  15      


Ile Ala Asp Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Asp Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile 
        35                  40                  45              


Ser Glu Val Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu 
    50                  55                  60                  


Phe Pro Asp Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His 
65                  70                  75                  80  


Leu Val Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr 
                85                  90                  95      


Leu Glu Lys Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro 
            100                 105                 110         


Lys Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Ala Lys Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val 
145                 150                 155                 160 


Ala Asn Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp 
                165                 170                 175     


Val Ala Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Ser Ala Ile Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu 
225                 230                 235                 240 


Lys Lys Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser 
            260                 265                 270         


Arg Tyr Pro Thr Gln Ile Ala Arg Tyr Lys His Ile Lys His Ser Thr 
        275                 280                 285             


Glu Ala Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln 
    290                 295                 300                 


Thr Lys Arg Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys 
305                 310                 315                 320 


Leu Val Asn Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr 
            340                 345                 350         


Cys Phe 
        


<210>  14
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  CeGalNAcT(30-383)-His

<400>  14

Lys Ile Pro Ser Leu Tyr Glu Asn Leu Thr Ile Gly Ser Ser Thr Leu 
1               5                   10                  15      


Ile Ala Asp Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser 
            20                  25                  30          


Thr Ser Asp Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile 
        35                  40                  45              


Ser Glu Val Asn Gln Thr Ser Phe Met Glu Asp Ile Arg Pro Ile Leu 
    50                  55                  60                  


Phe Pro Asp Asn Gln Thr Leu Gln Phe Cys Asn Gln Thr Pro Pro His 
65                  70                  75                  80  


Leu Val Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Lys Thr 
                85                  90                  95      


Leu Glu Lys Ile Tyr Pro Asp Thr His Ala Gly Gly His Gly Met Pro 
            100                 105                 110         


Lys Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Ala Lys Gln Gln Leu Asp Tyr Ala Ile Phe Ile Val Glu Gln Val 
145                 150                 155                 160 


Ala Asn Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp 
                165                 170                 175     


Val Ala Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Ile Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Ser Ala Ile Phe Gly Gly Ile Ser Ala Leu Thr Lys Asp His Leu 
225                 230                 235                 240 


Lys Lys Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser 
            260                 265                 270         


Arg Tyr Pro Thr Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr 
        275                 280                 285             


Glu Ala Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln 
    290                 295                 300                 


Thr Lys Arg Arg Trp Thr Arg Asp Gly Leu Ser Asn Leu Lys Tyr Lys 
305                 310                 315                 320 


Leu Val Asn Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Asp Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr 
            340                 345                 350         


Cys Phe His His His His His His 
        355                 360 


<210>  15
<211>  383
<212>  PRT
<213>  Caenorhabditis remanei

<400>  15

Met Ala Leu Arg His Leu Ala Val Ala Lys Leu Lys Thr Phe Phe Val 
1               5                   10                  15      


Leu Cys Ala Ala Leu Leu Leu Val His Thr Met Ile Tyr Lys Ala Pro 
            20                  25                  30          


Ser Leu Tyr Glu Asn Phe Ser Ile Gly Ser Ser Thr Leu Ile Ala Asp 
        35                  40                  45              


Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser Thr Ser Tyr 
    50                  55                  60                  


Asp Leu Leu Asp Thr Trp Asn Ser Thr Phe Ser Pro Ile Ser Glu Val 
65                  70                  75                  80  


Asn Gln Thr Ser Phe Leu Glu Asp Val Arg Pro Ile Leu Phe Thr Asp 
                85                  90                  95      


Asn Gln Thr Lys Pro Phe Cys Asn Gln Thr Pro Pro His Leu Val Gly 
            100                 105                 110         


Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Ala Thr Leu Glu Lys 
        115                 120                 125             


Ile Tyr Pro Asp Val His Thr Gly Gly His Gly Ile Pro Asp Glu Cys 
    130                 135                 140                 


Ile Ala Arg His Arg Val Ala Val Ile Val Pro Tyr Arg Asp Arg Glu 
145                 150                 155                 160 


Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu Leu Ala Lys 
                165                 170                 175     


Gln Gln Leu Asp Tyr Ala Ile Ile Val Val Glu Gln Ile Val Asn Gln 
            180                 185                 190         


Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp Val Ala Ser 
        195                 200                 205             


Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val Asp Leu Leu 
    210                 215                 220                 


Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln Pro Arg His 
225                 230                 235                 240 


Met Ser Val Ala Ile Asp Lys Phe Asp Tyr Lys Leu Pro Tyr Ser Thr 
                245                 250                 255     


Ile Phe Gly Gly Ile Ser Ala Leu Thr Gln Glu His Val Lys Lys Ile 
            260                 265                 270         


Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu Asp Asp Asp 
        275                 280                 285             


Leu Ala Thr Arg Thr Ser Met Ala Gly Leu Lys Val Ser Arg Tyr Pro 
    290                 295                 300                 


Ala Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr Glu Ala Thr 
305                 310                 315                 320 


Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln Thr Lys Arg 
                325                 330                 335     


Arg Trp Thr Arg Asp Gly Leu Ser Ser Leu Lys Tyr Lys Leu Val Lys 
            340                 345                 350         


Leu Asp Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp Leu Leu Glu 
        355                 360                 365             


Lys Asp Cys Arg Arg Glu Leu Arg Lys Asp Phe Pro Thr Cys Phe 
    370                 375                 380             


<210>  16
<211>  384
<212>  PRT
<213>  Caenorhabditis briggsae

<400>  16

Met Ala Phe Arg His Leu Ala Ser Ala Lys Leu Lys Thr Phe Phe Val 
1               5                   10                  15      


Leu Cys Ala Ala Leu Leu Leu Val His Ala Met Ile Tyr Lys Val Pro 
            20                  25                  30          


Ser Leu Tyr Glu Asn Phe Ser Ile Gly Ser Ser Thr Leu Ile Ala Asp 
        35                  40                  45              


Val Asp Ala Met Glu Ala Val Leu Gly Asn Thr Ala Ser Thr Ser Asp 
    50                  55                  60                  


Asp Pro Phe Asp Val Trp Asn Ser Thr Phe Ser Pro Ile Ser Glu Val 
65                  70                  75                  80  


Asn Gln Thr Ala Phe Met Glu Asp Ile Arg Pro Ile Leu Phe Gly Asp 
                85                  90                  95      


Ala Asn Glu Thr Arg Pro His Cys Asn Gln Thr Pro Pro His Leu Val 
            100                 105                 110         


Gly Pro Ile Arg Val Phe Leu Asp Glu Pro Asp Phe Ala Thr Leu Glu 
        115                 120                 125             


Lys Ile Tyr Pro Glu Thr His Pro Gly Gly His Gly Ile Pro Thr Glu 
    130                 135                 140                 


Cys Val Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg Asp Arg 
145                 150                 155                 160 


Glu Ala His Leu Arg Ile Met Leu His Asn Leu His Ser Leu Leu Ala 
                165                 170                 175     


Lys Gln Gln Leu Asp Tyr Ala Ile Phe Val Val Glu Gln Val Ala Asn 
            180                 185                 190         


Gln Thr Phe Asn Arg Gly Lys Leu Met Asn Val Gly Tyr Asp Val Ala 
        195                 200                 205             


Ser Arg Leu Tyr Pro Trp Gln Cys Phe Ile Phe His Asp Val Asp Leu 
    210                 215                 220                 


Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys Pro Ile Gln Pro Arg 
225                 230                 235                 240 


His Met Ser Val Ala Ile Asp Lys Phe His Tyr Lys Leu Pro Tyr Ser 
                245                 250                 255     


Ala Ile Phe Gly Gly Ile Ser Ala Leu Thr Gln Glu His Val Lys Ala 
            260                 265                 270         


Ile Asn Gly Phe Ser Asn Asp Phe Trp Gly Trp Gly Gly Glu Asp Asp 
        275                 280                 285             


Asp Leu Ala Thr Arg Thr Ser Gln Ala Gly Leu Lys Val Ser Arg Tyr 
    290                 295                 300                 


Pro Ala Gln Ile Ala Arg Tyr Lys Met Ile Lys His Ser Thr Glu Ala 
305                 310                 315                 320 


Thr Asn Pro Val Asn Lys Cys Arg Tyr Lys Ile Met Gly Gln Thr Lys 
                325                 330                 335     


Arg Arg Trp Lys Thr Asp Gly Leu Ser Ser Leu Lys Tyr Lys Leu Val 
            340                 345                 350         


Lys Leu Glu Leu Lys Pro Leu Tyr Thr Arg Ala Val Val Asp Leu Leu 
        355                 360                 365             


Glu Lys Glu Cys Arg Arg Glu Leu Arg Arg Asp Phe Pro Thr Cys Phe 
    370                 375                 380                 


<210>  17
<211>  464
<212>  PRT
<213>  Wuchereria bancrofti

<400>  17

Met Pro Ala Ala Gly Arg Phe Val Ile Ile Leu Leu Ile Phe Gly Ala 
1               5                   10                  15      


Ala Ala His Ile Phe Leu Gly Gly Gly Leu Ser Phe Ile Ser Asp Tyr 
            20                  25                  30          


His Ile Trp Arg Pro Val Val Glu Ser Ser Arg Gln Glu Ile Val Leu 
        35                  40                  45              


Val His Asn Ile Asp Asn Asn Ser Asp Gln Asn Ala Glu Lys Ile Ile 
    50                  55                  60                  


Ser Asn Asn Glu Thr Lys Phe His Leu Thr Ser Ala Thr Pro Ile Asp 
65                  70                  75                  80  


Asn Leu Val Ser Ile His Ser Asn Phe Tyr Glu Leu Phe Ile Asn Gly 
                85                  90                  95      


Leu Arg Phe Gly Lys Leu Thr Thr Val Tyr Pro Ile Ile Asn Gln Ser 
            100                 105                 110         


Ile Asn Asn Gly Ser Thr Thr Asp Lys Ser Thr Glu Thr Tyr Ala Glu 
        115                 120                 125             


Ser Val Tyr Phe Leu Lys Thr Asp Gly Asn Ile His Ser Asn Thr Leu 
    130                 135                 140                 


Leu Ser Thr Ile Thr Asp Ala Gln Ser Thr Arg Gln Leu Phe Gly Asn 
145                 150                 155                 160 


Glu Thr Leu Ser Ala Cys Asn Val Ile Pro Ser Phe Gln Met Met His 
                165                 170                 175     


Gln Asn Leu Ser Leu Val Asn Cys Pro Val Thr Pro Pro Gly Leu Val 
            180                 185                 190         


Gly Pro Ile Lys Val Trp Tyr Asp Glu Pro Thr Phe Glu Glu Ile Glu 
        195                 200                 205             


Arg Leu Asn Pro Asn Leu Glu Ala Gly Gly His Gly Lys Pro Glu Asn 
    210                 215                 220                 


Cys Leu Ser Arg His Arg Val Ala Val Ile Val Pro Tyr Arg Asp Arg 
225                 230                 235                 240 


Glu Ala His Leu Arg Ile Leu Leu His Asn Leu His Ser Leu Leu Thr 
                245                 250                 255     


Lys Gln Gln Leu Asp Tyr Gly Ile Phe Val Ile Glu Gln His Glu Asn 
            260                 265                 270         


Glu Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr Val Glu Ala 
        275                 280                 285             


Leu Lys Leu Tyr Asp Trp Gln Cys Phe Val Phe His Asp Val Asp Leu 
    290                 295                 300                 


Leu Ala Glu Asp Asp Arg Asn Ile Tyr Ser Cys Pro Asp Gln Pro Arg 
305                 310                 315                 320 


His Met Ser Val Ala Val Asn Lys Phe Lys Tyr Lys Leu Pro Tyr Gly 
                325                 330                 335     


Ser Ile Phe Gly Gly Val Ser Ala Ile Arg Thr Glu Gln Phe Ala Thr 
            340                 345                 350         


Leu Asn Gly Phe Ser Asn Ser Tyr Trp Gly Trp Gly Gly Glu Asp Asp 
        355                 360                 365             


Asp Leu Ser Met Arg Val Thr Ser Ala Gly Tyr Lys Ile Met Arg Tyr 
    370                 375                 380                 


Pro Ser Glu Ile Ala Arg Tyr Gln Met Val Gln His Lys Ser Glu Met 
385                 390                 395                 400 


Lys Asn Pro Ile Asn Arg Cys Arg Tyr Asp Leu Leu Ala Lys Thr Lys 
                405                 410                 415     


Val Arg Gln Gln Thr Asp Gly Ile Ser Ser Leu Lys Tyr Glu Cys Tyr 
            420                 425                 430         


Asp Leu Gln Phe Phe Thr Leu Phe Thr His Ile Lys Val Lys Leu Phe 
        435                 440                 445             


Glu Gln Glu Ser Lys Ala Gln Leu Arg Glu Glu Gly Phe Lys Arg Cys 
    450                 455                 460                 


<210>  18
<211>  291
<212>  PRT
<213>  Loa loa

<400>  18

Met Glu Arg Gln Asn Leu Ser Leu Val Asp Cys Pro Ile Ile Pro Pro 
1               5                   10                  15      


Gly Leu Val Gly Pro Ile Lys Val Trp Tyr Asp Glu Pro Thr Phe Glu 
            20                  25                  30          


Glu Ile Glu Arg Leu Asn Pro Tyr Leu Glu Leu Gly Gly His Gly Lys 
        35                  40                  45              


Pro Gly Ser Cys Leu Ser Arg His Arg Val Ala Ile Ile Val Pro Tyr 
    50                  55                  60                  


Arg Asp Arg Glu Ala His Leu Arg Ile Leu Leu His Asn Leu His Ser 
65                  70                  75                  80  


Leu Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe Val Ile Glu Gln 
                85                  90                  95      


His Glu Asn Glu Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr 
            100                 105                 110         


Thr Glu Ala Met Lys Leu Tyr Asp Trp Gln Cys Phe Ile Phe His Asp 
        115                 120                 125             


Val Asp Leu Leu Ala Glu Asp Asp Arg Asn Ile Tyr Ser Cys Pro Asp 
    130                 135                 140                 


Gln Pro Arg His Met Ser Val Ala Ile Asn Lys Phe Lys Tyr Arg Leu 
145                 150                 155                 160 


Pro Tyr Gly Ser Ile Phe Gly Gly Val Ser Ala Ile Arg Thr Glu Gln 
                165                 170                 175     


Phe Leu Lys Met Asn Gly Phe Ser Asn Ser Tyr Trp Gly Trp Gly Gly 
            180                 185                 190         


Glu Asp Asp Asp Leu Ser Ile Arg Val Thr Ser Leu Gly Tyr Lys Ile 
        195                 200                 205             


Met Arg Tyr Pro Leu Glu Ile Ala Arg Tyr Gln Met Val Lys His Glu 
    210                 215                 220                 


Ser Glu Thr Lys Asn Pro Ile Asn Arg Cys Arg Tyr Asp Leu Leu Ala 
225                 230                 235                 240 


Lys Thr Lys Val Arg Gln Gln Met Asp Gly Ile Ser Ser Leu Lys Tyr 
                245                 250                 255     


Glu Cys Tyr Asp Leu His Phe Leu Pro Leu Phe Thr His Ile Lys Val 
            260                 265                 270         


Lys Leu Phe Glu Gln Glu Ser Lys Ala Gln Leu Arg Glu Glu Gly Phe 
        275                 280                 285             


Lys Lys Cys 
    290     


<210>  19
<211>  296
<212>  PRT
<213>  Cerapachys biroi

<400>  19

Met Pro Ile Arg Asn Leu Ala Gly Asn Gly Gly Thr Ala Arg Glu Leu 
1               5                   10                  15      


Pro Val Ala Asn Thr Thr Ser Asn Ala Thr Ile Pro Arg Cys Pro Leu 
            20                  25                  30          


Ile Pro Pro Asn Leu Val Gly Pro Val Ala Val Ser Lys Ser Pro Pro 
        35                  40                  45              


Pro Leu Ser Glu Met Glu Arg Ser Phe Val Glu Val Lys Ala Gly Gly 
    50                  55                  60                  


Lys Gly Arg Pro Ala Asp Cys Val Ala Arg His Arg Val Ala Ile Ile 
65                  70                  75                  80  


Ile Pro Phe Arg Asp Arg Pro Gln His Leu Gln Thr Leu Leu Tyr Asn 
                85                  90                  95      


Leu His Pro Ile Leu Leu Arg Gln Gln Ile Asp Tyr Gln Ile Phe Val 
            100                 105                 110         


Ile Glu Gln Glu Gly Thr Gly Thr Phe Asn Arg Ala Met Leu Met Asn 
        115                 120                 125             


Val Gly Tyr Val Glu Ala Leu Lys Glu Arg Ile Phe Asp Cys Phe Ile 
    130                 135                 140                 


Phe His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr 
145                 150                 155                 160 


Cys Pro Glu Gln Pro Arg His Met Ser Val Ala Val Asp Lys Phe Lys 
                165                 170                 175     


Tyr Arg Leu Pro Tyr Ala Asp Leu Phe Gly Gly Val Ser Ala Met Ser 
            180                 185                 190         


Arg Glu His Phe Gln Leu Val Asn Gly Phe Ser Asn Val Phe Trp Gly 
        195                 200                 205             


Trp Gly Gly Glu Asp Asp Asp Met Ala Asn Arg Ile Lys Ala His Gly 
    210                 215                 220                 


Leu His Ile Ser Arg Tyr Pro Ala Asn Val Ala Arg Tyr Lys Met Leu 
225                 230                 235                 240 


Thr His Lys Lys Glu Lys Ala Asn Pro Lys Arg Tyr Glu Phe Leu Lys 
                245                 250                 255     


Thr Gly Lys Lys Arg Phe Ser Thr Asp Gly Leu Ala Asn Leu Gln Tyr 
            260                 265                 270         


Glu Leu Cys Asp Lys Arg Lys Pro Lys Leu Tyr Thr Trp Leu Leu Val 
        275                 280                 285             


Arg Leu Thr Pro Pro Gln Pro Ser 
    290                 295     


<210>  20
<211>  422
<212>  PRT
<213>  Zootermopsis nevadensis

<400>  20

Met Arg Cys Arg Cys Leu Ser Ala Trp Ser Arg Ile Thr Gln His Val 
1               5                   10                  15      


Pro Arg Gln Pro Cys Leu His Ile His Ser His Leu Cys Lys Val Val 
            20                  25                  30          


Ile Val Leu Ala Val Leu Ile Ala Leu Gln Phe Leu Leu Thr Thr Ile 
        35                  40                  45              


Phe Glu Ala Arg Gln Ile Glu Pro Leu Phe Thr Val Asn Phe Thr Tyr 
    50                  55                  60                  


Ser Gly Arg Arg Ser Arg Trp Gly Leu Ile Ser His Ser Arg Gly Leu 
65                  70                  75                  80  


Leu Ser Pro Ser His Asn Ser Ser Phe Asn Gly Ser Met Arg Val Ser 
                85                  90                  95      


Val Glu Arg Thr Leu Ser Pro Val Glu Asn Ile Ser Gly Glu Thr Lys 
            100                 105                 110         


Asn Leu Ser Phe Leu His Thr His Glu Asn Ala Val Arg Asn Ala Ser 
        115                 120                 125             


Ser Leu Val Leu Asn Ile Ser Leu Pro Ser Asp Leu Asn Pro Thr Thr 
    130                 135                 140                 


Ser Pro Ser Leu Thr Val Pro Phe Thr Gly Lys Ser Leu Cys Pro Pro 
145                 150                 155                 160 


Ile Pro Pro Asn Leu Asn Gly Pro Ile Lys Val Leu Lys Asp Ser Pro 
                165                 170                 175     


Ser Leu Glu Glu Leu Glu Lys Met Phe Pro Leu Leu Glu Pro Gly Gly 
            180                 185                 190         


His Tyr His Pro Glu Glu Cys Gln Ala Arg Asp Arg Val Ala Ile Ile 
        195                 200                 205             


Val Pro Tyr Arg Asp Arg Ala Glu His Leu Ser Thr Phe Leu Leu Asn 
    210                 215                 220                 


Leu His Pro Leu Leu Gln Arg Gln Gln Leu Asp Tyr Gly Met Phe Val 
225                 230                 235                 240 


Ile Glu Gln Gly Gly Asp Gly Pro Phe Asn Arg Ala Met Leu Met Asn 
                245                 250                 255     


Val Gly Phe Val Glu Ala Leu Lys Leu Tyr Ser Tyr Asp Cys Phe Ile 
            260                 265                 270         


Phe His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr 
        275                 280                 285             


Cys Pro Glu Gln Pro Arg His Met Ser Val Ala Val Asp Val Leu Lys 
    290                 295                 300                 


Tyr Lys Leu Pro Tyr Gln Ala Ile Phe Gly Gly Val Ser Ala Met Thr 
305                 310                 315                 320 


Lys Thr Gln Phe Gln Lys Val Asn Gly Phe Ser Asn Leu Phe Trp Gly 
                325                 330                 335     


Trp Gly Gly Glu Asp Asp Asp Met Ser Asn Arg Val Arg His His Gly 
            340                 345                 350         


Tyr His Ile Ser Arg Tyr Pro Ala Asn Ile Ala Arg Tyr Lys Met Leu 
        355                 360                 365             


Ala His Arg Lys Gln His Ala Asn Pro Lys Arg Tyr Glu Phe Leu Asn 
    370                 375                 380                 


Thr Gly Arg Lys Arg Phe Lys Thr Asp Gly Leu Ser Asn Leu Gln Tyr 
385                 390                 395                 400 


Asp Arg Lys Glu Leu Asn Leu Gly Lys Leu Tyr Thr Arg Val Leu Val 
                405                 410                 415     


Glu Leu Ala Thr Pro Ser 
            420         


<210>  21
<211>  295
<212>  PRT
<213>  Camponotus floridanus

<400>  21

Met Pro Thr Arg Asn Leu Val Gly Gly Gly Thr Ala Arg Glu Leu Pro 
1               5                   10                  15      


Val Ala Asn Ala Thr Asn Asn Thr Thr Met Pro Arg Cys Pro Leu Ile 
            20                  25                  30          


Pro Pro Asn Leu Val Gly Pro Met Val Val Ser Lys Ser Pro Pro Pro 
        35                  40                  45              


Leu Ser Glu Met Glu Arg Ser Phe Val Glu Val Asn Ala Gly Gly Arg 
    50                  55                  60                  


Gly Arg Pro Ala Asp Cys Val Ala Arg His Arg Val Ala Ile Ile Ile 
65                  70                  75                  80  


Pro Phe Arg Asp Arg Pro Gln His Leu Gln Thr Leu Leu Tyr Asn Leu 
                85                  90                  95      


His Pro Ile Leu Leu Arg Gln Gln Ile Glu Tyr Gln Ile Phe Val Ile 
            100                 105                 110         


Glu Gln Glu Gly Thr Gly Ala Phe Asn Arg Ala Met Leu Met Asn Val 
        115                 120                 125             


Gly Tyr Val Glu Ala Leu Lys Glu Arg Thr Phe Asp Cys Phe Ile Phe 
    130                 135                 140                 


His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Thr Cys 
145                 150                 155                 160 


Pro Glu Gln Pro Arg His Met Ser Val Ala Val Asp Lys Phe Lys Tyr 
                165                 170                 175     


Arg Leu Pro Tyr Thr Asp Leu Phe Gly Gly Val Ser Ala Met Ser Arg 
            180                 185                 190         


Glu His Phe Gln Leu Val Asn Gly Phe Ser Asn Val Phe Trp Gly Trp 
        195                 200                 205             


Gly Gly Glu Asp Asp Asp Met Ala Asn Arg Ile Lys Ala His Gly Leu 
    210                 215                 220                 


His Ile Ser Arg Tyr Pro Ala Asn Val Ala Arg Tyr Lys Met Leu Thr 
225                 230                 235                 240 


His Lys Lys Glu Lys Ala Asn Pro Lys Arg Tyr Glu Phe Leu Lys Thr 
                245                 250                 255     


Gly Lys Lys Arg Phe Ser Thr Asp Gly Leu Ala Asn Leu Gln Tyr Glu 
            260                 265                 270         


Leu Ser Asp Lys Arg Lys Pro Lys Leu Tyr Thr Trp Leu Leu Val Arg 
        275                 280                 285             


Leu Thr Pro Pro Gln Pro Ser 
    290                 295 


<210>  22
<211>  310
<212>  PRT
<213>  Crassostrea gigas

<400>  22

Met Asp Arg Gly Cys Lys Pro Met Arg Val Cys Ser Ser Ser Pro Ser 
1               5                   10                  15      


Asp Leu Val Gly Ser Leu Ala Thr Tyr Lys Glu Ala Pro Ser Tyr Lys 
            20                  25                  30          


Glu Met Ile Lys Ile Tyr Pro Leu Val Arg Pro Gly Gly Leu Tyr Thr 
        35                  40                  45              


Pro Pro Asp Cys Ile Ala Arg Glu Arg Val Ala Ile Ile Ile Pro Phe 
    50                  55                  60                  


Arg Asp Arg Glu Glu His Leu Arg Ile Leu Leu His Asn Leu His Pro 
65                  70                  75                  80  


Met Leu Gln Arg Gln Gln Leu Asp Tyr Gly Ile Tyr Val Val Glu Gln 
                85                  90                  95      


Glu Asn Gly Thr Gln Phe Asn Arg Ala Met Leu Met Asn Ile Gly Tyr 
            100                 105                 110         


Ala Glu Ser Ile Lys Leu Tyr Asn Tyr Thr Cys Phe Ile Phe His Asp 
        115                 120                 125             


Val Asp Leu Ile Pro Glu Asn Asp Arg Ile Met Tyr Asp Cys Arg Asp 
    130                 135                 140                 


Ser Pro Arg His Leu Ser Ser Ala Val Asp Lys Phe Lys Tyr Lys Leu 
145                 150                 155                 160 


Pro Tyr Pro Gln Leu Phe Gly Gly Val Thr Ala Ile Lys Arg Ala His 
                165                 170                 175     


Phe Glu Lys Val Asn Gly His Ser Asn Lys Phe Phe Gly Trp Gly Gly 
            180                 185                 190         


Glu Asp Asp Asp Met Phe Arg Arg Leu Val Asn Asn Gly Phe Lys Ile 
        195                 200                 205             


Ser Arg Tyr Gln Ala Ser Leu Ser Lys Tyr Lys Met Ile Lys His Leu 
    210                 215                 220                 


His Asp Ala Gly Asn Lys Ala Asn Lys Arg Arg His His Leu Ile Lys 
225                 230                 235                 240 


Thr Gly Lys Gly Arg Tyr Arg Arg Asp Gly Ile Asn Asn Leu His Tyr 
                245                 250                 255     


Lys Lys Leu Gly Ile Glu Tyr Gln Tyr Leu His Thr Arg Ile Leu Val 
            260                 265                 270         


Ser Ile Asn Glu Thr Lys Val Met Thr Val Ser Leu Leu Tyr Met Tyr 
        275                 280                 285             


Ser Ser Thr Thr Val Tyr Ile Ile Val Asn Ile Tyr Thr Ile Tyr Cys 
    290                 295                 300                 


Lys Ser Arg Asn Ile Arg 
305                 310 


<210>  23
<211>  338
<212>  PRT
<213>  Danaus plexippus

<400>  23

Met Ala Lys Lys Leu Leu Thr Gln Gly Thr Glu Ser Val Thr Asn Tyr 
1               5                   10                  15      


Thr His Thr Thr Asn Ser Ser Asn Lys Asn Pro Ala Lys Glu Thr Phe 
            20                  25                  30          


Asn Met Thr Lys Pro Asn Leu Ser Asp Asp Thr Ser Thr Pro Leu Leu 
        35                  40                  45              


Ile Thr Lys Ile Met Glu Ser Ile Lys Asn Leu Val Thr Thr Glu Glu 
    50                  55                  60                  


Asp Phe Arg Asp Glu Pro Ser Leu Pro Leu Cys Asp Glu Met Pro Pro 
65                  70                  75                  80  


Asp Leu Gly Pro Ile Ser Val Asn Lys Thr Glu Ile Glu Leu Asp Trp 
                85                  90                  95      


Val Glu Lys Arg Tyr Pro Glu Val Arg Ser Gly Gly Ile Tyr Ser Ser 
            100                 105                 110         


Ser Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro Phe 
    130                 135                 140                 


Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Tyr Ile Ile Glu Gln Glu 
145                 150                 155                 160 


Gly Thr Ser Glu Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe Val 
                165                 170                 175     


Glu Ser Gln Arg Gln Arg Ser Trp Gln Cys Phe Ile Phe His Asp Ile 
            180                 185                 190         


Asp Leu Leu Pro Leu Asp Ser Arg Asn Met Tyr Ser Cys Pro Lys Gln 
        195                 200                 205             


Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu Asn Phe Arg Leu Pro 
    210                 215                 220                 


Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu Glu Gln Phe 
225                 230                 235                 240 


Thr Lys Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Met Phe Tyr Arg Leu Lys Lys Met Asn Tyr His Ile Ala 
            260                 265                 270         


Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp His Lys Lys 
        275                 280                 285             


Ser Ala Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln Thr Ser Lys 
    290                 295                 300                 


Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu Val Ile Lys 
305                 310                 315                 320 


Val Thr Ala Asn His Leu Tyr Thr His Ile Leu Val Asn Ile Asp Glu 
                325                 330                 335     


Arg Ser 
        


<210>  24
<211>  941
<212>  PRT
<213>  Artificial

<220>
<223>  HuGalNAcT (57-998)

<400>  24

Arg Tyr Gly Ser Trp Arg Glu Leu Ala Lys Ala Leu Ala Ser Arg Asn 
1               5                   10                  15      


Ile Pro Ala Val Asp Pro His Leu Gln Phe Tyr His Pro Gln Arg Leu 
            20                  25                  30          


Ser Leu Glu Asp His Asp Ile Asp Gln Gly Val Ser Ser Asn Ser Ser 
        35                  40                  45              


Tyr Leu Lys Trp Asn Lys Pro Val Pro Trp Leu Ser Glu Phe Arg Gly 
    50                  55                  60                  


Arg Ala Asn Leu His Val Phe Glu Asp Trp Cys Gly Ser Ser Ile Gln 
65                  70                  75                  80  


Gln Leu Arg Arg Asn Leu His Phe Pro Leu Tyr Pro His Ile Arg Thr 
                85                  90                  95      


Thr Leu Arg Lys Leu Ala Val Ser Pro Lys Trp Thr Asn Tyr Gly Leu 
            100                 105                 110         


Arg Ile Phe Gly Tyr Leu His Pro Phe Thr Asp Gly Lys Ile Gln Phe 
        115                 120                 125             


Ala Ile Ala Ala Asp Asp Asn Ala Glu Phe Trp Leu Ser Leu Asp Asp 
    130                 135                 140                 


Gln Val Ser Gly Leu Gln Leu Leu Ala Ser Val Gly Lys Thr Gly Lys 
145                 150                 155                 160 


Glu Trp Thr Ala Pro Gly Glu Phe Gly Lys Phe Arg Ser Gln Ile Ser 
                165                 170                 175     


Lys Pro Val Ser Leu Ser Ala Ser His Arg Tyr Tyr Phe Glu Val Leu 
            180                 185                 190         


His Lys Gln Asn Glu Glu Gly Thr Asp His Val Glu Val Ala Trp Arg 
        195                 200                 205             


Arg Asn Asp Pro Gly Ala Lys Phe Thr Ile Ile Asp Ser Leu Ser Leu 
    210                 215                 220                 


Ser Leu Phe Thr Asn Glu Thr Phe Leu Gln Met Asp Glu Val Gly His 
225                 230                 235                 240 


Ile Pro Gln Thr Ala Ala Ser His Val Asp Ser Ser Asn Ala Leu Pro 
                245                 250                 255     


Arg Asp Glu Gln Pro Pro Ala Asp Met Leu Arg Pro Asp Pro Arg Asp 
            260                 265                 270         


Thr Leu Tyr Arg Val Pro Leu Ile Pro Lys Ser His Leu Arg His Val 
        275                 280                 285             


Leu Pro Asp Cys Pro Tyr Lys Pro Ser Tyr Leu Val Asp Gly Leu Pro 
    290                 295                 300                 


Leu Gln Arg Tyr Gln Gly Leu Arg Phe Val His Leu Ser Phe Val Tyr 
305                 310                 315                 320 


Pro Asn Asp Tyr Thr Arg Leu Ser His Met Glu Thr His Asn Lys Cys 
                325                 330                 335     


Phe Tyr Gln Glu Asn Ala Tyr Tyr Gln Asp Arg Phe Ser Phe Gln Glu 
            340                 345                 350         


Tyr Ile Lys Ile Asp Gln Pro Glu Lys Gln Gly Leu Glu Gln Pro Gly 
        355                 360                 365             


Phe Glu Glu Asn Leu Leu Glu Glu Ser Gln Tyr Gly Glu Val Ala Glu 
    370                 375                 380                 


Glu Thr Pro Ala Ser Asn Asn Gln Asn Ala Arg Met Leu Glu Gly Arg 
385                 390                 395                 400 


Gln Thr Pro Ala Ser Thr Leu Glu Gln Asp Ala Thr Asp Tyr Arg Leu 
                405                 410                 415     


Arg Ser Leu Arg Lys Leu Leu Ala Gln Pro Arg Glu Gly Leu Leu Ala 
            420                 425                 430         


Pro Phe Ser Lys Arg Asn Ser Thr Ala Ser Phe Pro Gly Arg Thr Ser 
        435                 440                 445             


His Ile Pro Val Gln Gln Pro Glu Lys Arg Lys Gln Lys Pro Ser Pro 
    450                 455                 460                 


Glu Pro Ser Gln Asp Ser Pro His Ser Asp Lys Trp Pro Pro Gly His 
465                 470                 475                 480 


Pro Val Lys Asn Leu Pro Gln Met Arg Gly Pro Arg Pro Arg Pro Ala 
                485                 490                 495     


Gly Asp Ser Pro Arg Lys Thr Gln Trp Leu Asn Gln Val Glu Ser Tyr 
            500                 505                 510         


Ile Ala Glu Gln Arg Arg Gly Asp Arg Met Arg Pro Gln Ala Pro Gly 
        515                 520                 525             


Arg Gly Trp His Gly Glu Glu Glu Val Val Ala Ala Ala Gly Gln Glu 
    530                 535                 540                 


Gly Gln Val Glu Gly Glu Glu Glu Gly Glu Glu Glu Glu Glu Glu Glu 
545                 550                 555                 560 


Asp Met Ser Glu Val Phe Glu Tyr Val Pro Val Phe Asp Pro Val Val 
                565                 570                 575     


Asn Trp Asp Gln Thr Phe Ser Ala Arg Asn Leu Asp Phe Gln Ala Leu 
            580                 585                 590         


Arg Thr Asp Trp Ile Asp Leu Ser Cys Asn Thr Ser Gly Asn Leu Leu 
        595                 600                 605             


Leu Pro Glu Gln Glu Ala Leu Glu Val Thr Arg Val Phe Leu Lys Lys 
    610                 615                 620                 


Leu Asn Gln Arg Ser Arg Gly Arg Tyr Gln Leu Gln Arg Ile Val Asn 
625                 630                 635                 640 


Val Glu Lys Arg Gln Asp Gln Leu Arg Gly Gly Arg Tyr Leu Leu Glu 
                645                 650                 655     


Leu Glu Leu Leu Glu Gln Gly Gln Arg Val Val Arg Leu Ser Glu Tyr 
            660                 665                 670         


Val Ser Ala Arg Gly Trp Gln Gly Ile Asp Pro Ala Gly Gly Glu Glu 
        675                 680                 685             


Val Glu Ala Arg Asn Leu Gln Gly Leu Val Trp Asp Pro His Asn Arg 
    690                 695                 700                 


Arg Arg Gln Val Leu Asn Thr Arg Ala Gln Glu Pro Lys Leu Cys Trp 
705                 710                 715                 720 


Pro Gln Gly Phe Ser Trp Ser His Arg Ala Val Val His Phe Val Val 
                725                 730                 735     


Pro Val Lys Asn Gln Ala Arg Trp Val Gln Gln Phe Ile Lys Asp Met 
            740                 745                 750         


Glu Asn Leu Phe Gln Val Thr Gly Asp Pro His Phe Asn Ile Val Ile 
        755                 760                 765             


Thr Asp Tyr Ser Ser Glu Asp Met Asp Val Glu Met Ala Leu Lys Arg 
    770                 775                 780                 


Ser Lys Leu Arg Ser Tyr Gln Tyr Val Lys Leu Ser Gly Asn Phe Glu 
785                 790                 795                 800 


Arg Ser Ala Gly Leu Gln Ala Gly Ile Asp Leu Val Lys Asp Pro His 
                805                 810                 815     


Ser Ile Ile Phe Leu Cys Asp Leu His Ile His Phe Pro Ala Gly Val 
            820                 825                 830         


Ile Asp Ala Ile Arg Lys His Cys Val Glu Gly Lys Met Ala Phe Ala 
        835                 840                 845             


Pro Met Val Met Arg Leu His Cys Gly Ala Thr Pro Gln Trp Pro Glu 
    850                 855                 860                 


Gly Tyr Trp Glu Val Asn Gly Phe Gly Leu Leu Gly Ile Tyr Lys Ser 
865                 870                 875                 880 


Asp Leu Asp Arg Ile Gly Gly Met Asn Thr Lys Glu Phe Arg Asp Arg 
                885                 890                 895     


Trp Gly Gly Glu Asp Trp Glu Leu Leu Asp Arg Ile Leu Gln Gly Leu 
            900                 905                 910         


Asp Val Glu Arg Leu Ser Leu Arg Asn Phe Phe His His Phe His Ser 
        915                 920                 925             


Lys Arg Gly Met Trp Ser Arg Arg Gln Met Lys Thr Leu 
    930                 935                 940     


<210>  25
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; W336F)

<400>  25

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Phe 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  26
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; W336H)

<400>  26

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  27
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; W336V)

<400>  27

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Val 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  28
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; E339A)

<400>  28

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  29
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; E339G)

<400>  29

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Gly Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  30
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; E339D)

<400>  30

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  31
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; E339S)

<400>  31

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  32
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; W336H,E339A)

<400>  32

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  33
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; W336H,E339D)

<400>  33

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  34
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; W336H,E339S)

<400>  34

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  35
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y)

<400>  35

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  36
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,W336F)

<400>  36

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Phe 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  37
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,W336H)

<400>  37

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  38
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,W336V)

<400>  38

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Val 
    290                 295                 300                 


Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  39
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,E339A)

<400>  39

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  40
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,E339G)

<400>  40

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Gly Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  41
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,E339D)

<400>  41

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  42
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,E339S)

<400>  42

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly Trp 
    290                 295                 300                 


Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  43
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,W336H,E339A)

<400>  43

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  44
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,W336H,E339D)

<400>  44

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  45
<211>  389
<212>  PRT
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421; I311Y,W336H,E339S)

<400>  45

Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr Asn Ala Thr Gln 
1               5                   10                  15      


Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn Trp Pro Lys Lys 
            20                  25                  30          


Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr Ser Ile Lys Asn 
        35                  40                  45              


Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val Val His Pro Pro 
    50                  55                  60                  


Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys Asn Met Thr Ile 
65                  70                  75                  80  


Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro Leu Leu Ile Thr 
                85                  90                  95      


Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr Glu Asp Gly Val 
            100                 105                 110         


Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys Asp Ser Met Pro 
        115                 120                 125             


Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu Leu Glu Leu Glu 
    130                 135                 140                 


Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly Gly Arg Tyr Ser 
145                 150                 155                 160 


Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile Ile Val Pro Tyr 
                165                 170                 175     


Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn His Met His Pro 
            180                 185                 190         


Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe Ile Val Glu Gln 
        195                 200                 205             


Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met Asn Val Gly Phe 
    210                 215                 220                 


Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln Cys Phe Val Phe 
225                 230                 235                 240 


His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn Leu Tyr Ser Cys 
                245                 250                 255     


Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp Lys Leu His Phe 
            260                 265                 270         


Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser Ala Met Thr Leu 
        275                 280                 285             


Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys Tyr Trp Gly His 
    290                 295                 300                 


Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu Lys Lys Ile Asn Tyr 
305                 310                 315                 320 


His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr Ala Met Leu Asp 
                325                 330                 335     


His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln Leu Leu Ser Gln 
            340                 345                 350         


Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr Leu Glu Tyr Glu 
        355                 360                 365             


Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His Ile Leu Val Asn 
    370                 375                 380                 


Ile Asp Glu Arg Ser 
385                 


<210>  46
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  AsGalNAcT(30-383; W282H)

<400>  46

Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile Ser Ala Pro Lys Thr 
1               5                   10                  15      


Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr Ser Thr Asn Asp Leu 
            20                  25                  30          


Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser Met Leu Asp Asn Ser 
        35                  40                  45              


Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn Asp Glu Leu Val Met 
    50                  55                  60                  


Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro Met Thr Pro Pro Ala 
65                  70                  75                  80  


Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala Pro Ser Phe Ala Glu 
                85                  90                  95      


Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly Gly His Gly Met Pro 
            100                 105                 110         


Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile Val Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ser His Leu Arg Thr Phe Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe Val Val Glu Gln Thr 
145                 150                 155                 160 


Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr Ala 
                165                 170                 175     


Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Ser Cys Pro Asp Glu 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Val Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Gly Ser Ile Phe Gly Gly Ile Ser Ala Leu Thr Arg Glu Gln Phe 
225                 230                 235                 240 


Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp Gly His Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala Gly Tyr Lys Ile Ser 
            260                 265                 270         


Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met Ile Lys His Asn Ser 
        275                 280                 285             


Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr Lys Leu Met Ser Ala 
    290                 295                 300                 


Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser Ser Leu Ser Tyr Asp 
305                 310                 315                 320 


Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr His Ile Lys Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg Thr His Gly Phe Pro 
            340                 345                 350         


Thr Cys 
        


<210>  47
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  AsGalNAcT(30-383; E285D)

<400>  47

Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile Ser Ala Pro Lys Thr 
1               5                   10                  15      


Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr Ser Thr Asn Asp Leu 
            20                  25                  30          


Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser Met Leu Asp Asn Ser 
        35                  40                  45              


Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn Asp Glu Leu Val Met 
    50                  55                  60                  


Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro Met Thr Pro Pro Ala 
65                  70                  75                  80  


Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala Pro Ser Phe Ala Glu 
                85                  90                  95      


Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly Gly His Gly Met Pro 
            100                 105                 110         


Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile Val Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ser His Leu Arg Thr Phe Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe Val Val Glu Gln Thr 
145                 150                 155                 160 


Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr Ala 
                165                 170                 175     


Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Ser Cys Pro Asp Glu 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Val Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Gly Ser Ile Phe Gly Gly Ile Ser Ala Leu Thr Arg Glu Gln Phe 
225                 230                 235                 240 


Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp Gly Trp Gly Gly Asp 
                245                 250                 255     


Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala Gly Tyr Lys Ile Ser 
            260                 265                 270         


Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met Ile Lys His Asn Ser 
        275                 280                 285             


Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr Lys Leu Met Ser Ala 
    290                 295                 300                 


Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser Ser Leu Ser Tyr Asp 
305                 310                 315                 320 


Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr His Ile Lys Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg Thr His Gly Phe Pro 
            340                 345                 350         


Thr Cys 
        


<210>  48
<211>  354
<212>  PRT
<213>  Artificial

<220>
<223>  AsGalNAcT(30-383; I257Y)

<400>  48

Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile Ser Ala Pro Lys Thr 
1               5                   10                  15      


Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr Ser Thr Asn Asp Leu 
            20                  25                  30          


Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser Met Leu Asp Asn Ser 
        35                  40                  45              


Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn Asp Glu Leu Val Met 
    50                  55                  60                  


Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro Met Thr Pro Pro Ala 
65                  70                  75                  80  


Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala Pro Ser Phe Ala Glu 
                85                  90                  95      


Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly Gly His Gly Met Pro 
            100                 105                 110         


Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile Val Val Pro Tyr Arg 
        115                 120                 125             


Asp Arg Glu Ser His Leu Arg Thr Phe Leu His Asn Leu His Ser Leu 
    130                 135                 140                 


Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe Val Val Glu Gln Thr 
145                 150                 155                 160 


Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met Asn Val Gly Tyr Ala 
                165                 170                 175     


Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe Ile Phe His Asp Val 
            180                 185                 190         


Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr Ser Cys Pro Asp Glu 
        195                 200                 205             


Pro Arg His Met Ser Val Ala Val Asp Lys Phe Asn Tyr Lys Leu Pro 
    210                 215                 220                 


Tyr Gly Ser Tyr Phe Gly Gly Ile Ser Ala Leu Thr Arg Glu Gln Phe 
225                 230                 235                 240 


Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp Gly Trp Gly Gly Glu 
                245                 250                 255     


Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala Gly Tyr Lys Ile Ser 
            260                 265                 270         


Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met Ile Lys His Asn Ser 
        275                 280                 285             


Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr Lys Leu Met Ser Ala 
    290                 295                 300                 


Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser Ser Leu Ser Tyr Asp 
305                 310                 315                 320 


Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr His Ile Lys Val Asp 
                325                 330                 335     


Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg Thr His Gly Phe Pro 
            340                 345                 350         


Thr Cys 
        


<210>  49
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421)

<400>  49

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  50
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; W336F)

<400>  50

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Phe Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  51
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; W336H)

<400>  51

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  52
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; W336V)

<400>  52

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Val Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  53
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; E339A)

<400>  53

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  54
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; E339G)

<400>  54

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Gly Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  55
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; E339D)

<400>  55

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  56
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; E339S)

<400>  56

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  57
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; W336H,E339A)

<400>  57

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  58
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; W336H,E339D)

<400>  58

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  59
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; W336H,E339S)

<400>  59

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Ile Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  60
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y)

<400>  60

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  61
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,W336F)

<400>  61

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Phe Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  62
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,W336H)

<400>  62

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  63
<211>  409
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,W336V)

<400>  63

Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg 
1               5                   10                  15      


Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu Tyr 
            20                  25                  30          


Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala Asn 
        35                  40                  45              


Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu Tyr 
    50                  55                  60                  


Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser Val 
65                  70                  75                  80  


Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp Lys 
                85                  90                  95      


Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr Pro 
            100                 105                 110         


Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr Thr 
        115                 120                 125             


Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu Cys 
    130                 135                 140                 


Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr Glu 
145                 150                 155                 160 


Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp Gly 
                165                 170                 175     


Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala Ile 
            180                 185                 190         


Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu Asn 
        195                 200                 205             


His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile Phe 
    210                 215                 220                 


Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu Met 
225                 230                 235                 240 


Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp Gln 
                245                 250                 255     


Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg Asn 
            260                 265                 270         


Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile Asp 
        275                 280                 285             


Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val Ser 
    290                 295                 300                 


Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn Lys 
305                 310                 315                 320 


Tyr Trp Gly Val Gly Gly Glu Asp Asp Asp Met Ser Tyr Arg Leu Lys 
                325                 330                 335     


Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg Tyr 
            340                 345                 350         


Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr Gln 
        355                 360                 365             


Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser Thr 
    370                 375                 380                 


Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr His 
385                 390                 395                 400 


Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 


<210>  64
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,E339A)

<400>  64

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  65
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,E339G)

<400>  65

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Gly Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  66
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,E339D)

<400>  66

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  67
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,E339S)

<400>  67

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly Trp Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  68
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,W336H,E339A)

<400>  68

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Ala Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  69
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,W336H,E339D)

<400>  69

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Asp Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  70
<211>  410
<212>  PRT
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421; I311Y,W336H,E339S)

<400>  70

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Ser Pro Leu Arg Thr Tyr Leu Tyr Thr Pro Leu 
            20                  25                  30          


Tyr Asn Ala Thr Gln Pro Thr Leu Arg Asn Val Glu Arg Leu Ala Ala 
        35                  40                  45              


Asn Trp Pro Lys Lys Ile Pro Ser Asn Tyr Ile Glu Asp Ser Glu Glu 
    50                  55                  60                  


Tyr Ser Ile Lys Asn Ile Ser Leu Ser Asn His Thr Thr Arg Ala Ser 
65                  70                  75                  80  


Val Val His Pro Pro Ser Ser Ile Thr Glu Thr Ala Ser Lys Leu Asp 
                85                  90                  95      


Lys Asn Met Thr Ile Gln Asp Gly Ala Phe Ala Met Ile Ser Pro Thr 
            100                 105                 110         


Pro Leu Leu Ile Thr Lys Leu Met Asp Ser Ile Lys Ser Tyr Val Thr 
        115                 120                 125             


Thr Glu Asp Gly Val Lys Lys Ala Glu Ala Val Val Thr Leu Pro Leu 
    130                 135                 140                 


Cys Asp Ser Met Pro Pro Asp Leu Gly Pro Ile Thr Leu Asn Lys Thr 
145                 150                 155                 160 


Glu Leu Glu Leu Glu Trp Val Glu Lys Lys Phe Pro Glu Val Glu Trp 
                165                 170                 175     


Gly Gly Arg Tyr Ser Pro Pro Asn Cys Thr Ala Arg His Arg Val Ala 
            180                 185                 190         


Ile Ile Val Pro Tyr Arg Asp Arg Gln Gln His Leu Ala Ile Phe Leu 
        195                 200                 205             


Asn His Met His Pro Phe Leu Met Lys Gln Gln Ile Glu Tyr Gly Ile 
    210                 215                 220                 


Phe Ile Val Glu Gln Glu Gly Asn Lys Asp Phe Asn Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asn Val Gly Phe Val Glu Ser Gln Lys Leu Val Ala Glu Gly Trp 
                245                 250                 255     


Gln Cys Phe Val Phe His Asp Ile Asp Leu Leu Pro Leu Asp Thr Arg 
            260                 265                 270         


Asn Leu Tyr Ser Cys Pro Arg Gln Pro Arg His Met Ser Ala Ser Ile 
        275                 280                 285             


Asp Lys Leu His Phe Lys Leu Pro Tyr Glu Asp Tyr Phe Gly Gly Val 
    290                 295                 300                 


Ser Ala Met Thr Leu Glu Gln Phe Thr Arg Val Asn Gly Phe Ser Asn 
305                 310                 315                 320 


Lys Tyr Trp Gly His Gly Gly Ser Asp Asp Asp Met Ser Tyr Arg Leu 
                325                 330                 335     


Lys Lys Ile Asn Tyr His Ile Ala Arg Tyr Lys Met Ser Ile Ala Arg 
            340                 345                 350         


Tyr Ala Met Leu Asp His Lys Lys Ser Thr Pro Asn Pro Lys Arg Tyr 
        355                 360                 365             


Gln Leu Leu Ser Gln Thr Ser Lys Thr Phe Gln Lys Asp Gly Leu Ser 
    370                 375                 380                 


Thr Leu Glu Tyr Glu Leu Val Gln Val Val Gln Tyr His Leu Tyr Thr 
385                 390                 395                 400 


His Ile Leu Val Asn Ile Asp Glu Arg Ser 
                405                 410 


<210>  71
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  His-AsGalNAcT(30-383)

<400>  71

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile 
            20                  25                  30          


Ser Ala Pro Lys Thr Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr 
        35                  40                  45              


Ser Thr Asn Asp Leu Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser 
    50                  55                  60                  


Met Leu Asp Asn Ser Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn 
65                  70                  75                  80  


Asp Glu Leu Val Met Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro 
                85                  90                  95      


Met Thr Pro Pro Ala Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala 
            100                 105                 110         


Pro Ser Phe Ala Glu Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly 
        115                 120                 125             


Gly His Gly Met Pro Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile 
    130                 135                 140                 


Val Val Pro Tyr Arg Asp Arg Glu Ser His Leu Arg Thr Phe Leu His 
145                 150                 155                 160 


Asn Leu His Ser Leu Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe 
                165                 170                 175     


Val Val Glu Gln Thr Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met 
            180                 185                 190         


Asn Val Gly Tyr Ala Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe 
        195                 200                 205             


Ile Phe His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr 
    210                 215                 220                 


Ser Cys Pro Asp Glu Pro Arg His Met Ser Val Ala Val Asp Lys Phe 
225                 230                 235                 240 


Asn Tyr Lys Leu Pro Tyr Gly Ser Ile Phe Gly Gly Ile Ser Ala Leu 
                245                 250                 255     


Thr Arg Glu Gln Phe Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp 
            260                 265                 270         


Gly Trp Gly Gly Glu Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala 
        275                 280                 285             


Gly Tyr Lys Ile Ser Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met 
    290                 295                 300                 


Ile Lys His Asn Ser Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr 
305                 310                 315                 320 


Lys Leu Met Ser Ala Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser 
                325                 330                 335     


Ser Leu Ser Tyr Asp Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr 
            340                 345                 350         


His Ile Lys Val Asp Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg 
        355                 360                 365             


Thr His Gly Phe Pro Thr Cys 
    370                 375 


<210>  72
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  His-AsGalNAcT(30-383; W282H)

<400>  72

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile 
            20                  25                  30          


Ser Ala Pro Lys Thr Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr 
        35                  40                  45              


Ser Thr Asn Asp Leu Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser 
    50                  55                  60                  


Met Leu Asp Asn Ser Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn 
65                  70                  75                  80  


Asp Glu Leu Val Met Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro 
                85                  90                  95      


Met Thr Pro Pro Ala Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala 
            100                 105                 110         


Pro Ser Phe Ala Glu Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly 
        115                 120                 125             


Gly His Gly Met Pro Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile 
    130                 135                 140                 


Val Val Pro Tyr Arg Asp Arg Glu Ser His Leu Arg Thr Phe Leu His 
145                 150                 155                 160 


Asn Leu His Ser Leu Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe 
                165                 170                 175     


Val Val Glu Gln Thr Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met 
            180                 185                 190         


Asn Val Gly Tyr Ala Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe 
        195                 200                 205             


Ile Phe His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr 
    210                 215                 220                 


Ser Cys Pro Asp Glu Pro Arg His Met Ser Val Ala Val Asp Lys Phe 
225                 230                 235                 240 


Asn Tyr Lys Leu Pro Tyr Gly Ser Ile Phe Gly Gly Ile Ser Ala Leu 
                245                 250                 255     


Thr Arg Glu Gln Phe Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp 
            260                 265                 270         


Gly His Gly Gly Glu Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala 
        275                 280                 285             


Gly Tyr Lys Ile Ser Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met 
    290                 295                 300                 


Ile Lys His Asn Ser Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr 
305                 310                 315                 320 


Lys Leu Met Ser Ala Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser 
                325                 330                 335     


Ser Leu Ser Tyr Asp Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr 
            340                 345                 350         


His Ile Lys Val Asp Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg 
        355                 360                 365             


Thr His Gly Phe Pro Thr Cys 
    370                 375 


<210>  73
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  His-AsGalNAcT(30-383; E285D)

<400>  73

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile 
            20                  25                  30          


Ser Ala Pro Lys Thr Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr 
        35                  40                  45              


Ser Thr Asn Asp Leu Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser 
    50                  55                  60                  


Met Leu Asp Asn Ser Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn 
65                  70                  75                  80  


Asp Glu Leu Val Met Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro 
                85                  90                  95      


Met Thr Pro Pro Ala Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala 
            100                 105                 110         


Pro Ser Phe Ala Glu Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly 
        115                 120                 125             


Gly His Gly Met Pro Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile 
    130                 135                 140                 


Val Val Pro Tyr Arg Asp Arg Glu Ser His Leu Arg Thr Phe Leu His 
145                 150                 155                 160 


Asn Leu His Ser Leu Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe 
                165                 170                 175     


Val Val Glu Gln Thr Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met 
            180                 185                 190         


Asn Val Gly Tyr Ala Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe 
        195                 200                 205             


Ile Phe His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr 
    210                 215                 220                 


Ser Cys Pro Asp Glu Pro Arg His Met Ser Val Ala Val Asp Lys Phe 
225                 230                 235                 240 


Asn Tyr Lys Leu Pro Tyr Gly Ser Ile Phe Gly Gly Ile Ser Ala Leu 
                245                 250                 255     


Thr Arg Glu Gln Phe Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp 
            260                 265                 270         


Gly Trp Gly Gly Asp Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala 
        275                 280                 285             


Gly Tyr Lys Ile Ser Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met 
    290                 295                 300                 


Ile Lys His Asn Ser Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr 
305                 310                 315                 320 


Lys Leu Met Ser Ala Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser 
                325                 330                 335     


Ser Leu Ser Tyr Asp Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr 
            340                 345                 350         


His Ile Lys Val Asp Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg 
        355                 360                 365             


Thr His Gly Phe Pro Thr Cys 
    370                 375 


<210>  74
<211>  375
<212>  PRT
<213>  Artificial

<220>
<223>  His-AsGalNAcT(30-383; I257Y)

<400>  74

Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser His Met Asp Tyr Ser Phe Trp Ser Pro Ala Phe Ile Ile 
            20                  25                  30          


Ser Ala Pro Lys Thr Leu Thr Thr Leu Gln Pro Phe Ser Gln Ser Thr 
        35                  40                  45              


Ser Thr Asn Asp Leu Ala Val Ser Ala Leu Glu Ser Val Glu Phe Ser 
    50                  55                  60                  


Met Leu Asp Asn Ser Ser Ile Leu His Ala Ser Asp Asn Trp Thr Asn 
65                  70                  75                  80  


Asp Glu Leu Val Met Arg Ala Gln Asn Glu Asn Leu Gln Leu Cys Pro 
                85                  90                  95      


Met Thr Pro Pro Ala Leu Val Gly Pro Ile Lys Val Trp Met Asp Ala 
            100                 105                 110         


Pro Ser Phe Ala Glu Leu Glu Arg Leu Tyr Pro Phe Leu Glu Pro Gly 
        115                 120                 125             


Gly His Gly Met Pro Thr Ala Cys Arg Ala Arg His Arg Val Ala Ile 
    130                 135                 140                 


Val Val Pro Tyr Arg Asp Arg Glu Ser His Leu Arg Thr Phe Leu His 
145                 150                 155                 160 


Asn Leu His Ser Leu Leu Thr Lys Gln Gln Leu Asp Tyr Ala Ile Phe 
                165                 170                 175     


Val Val Glu Gln Thr Ala Asn Glu Thr Phe Asn Arg Ala Lys Leu Met 
            180                 185                 190         


Asn Val Gly Tyr Ala Glu Ala Ile Arg Leu Tyr Asp Trp Arg Cys Phe 
        195                 200                 205             


Ile Phe His Asp Val Asp Leu Leu Pro Glu Asp Asp Arg Asn Leu Tyr 
    210                 215                 220                 


Ser Cys Pro Asp Glu Pro Arg His Met Ser Val Ala Val Asp Lys Phe 
225                 230                 235                 240 


Asn Tyr Lys Leu Pro Tyr Gly Ser Tyr Phe Gly Gly Ile Ser Ala Leu 
                245                 250                 255     


Thr Arg Glu Gln Phe Glu Gly Ile Asn Gly Phe Ser Asn Asp Tyr Trp 
            260                 265                 270         


Gly Trp Gly Gly Glu Asp Asp Asp Leu Ser Thr Arg Val Thr Leu Ala 
        275                 280                 285             


Gly Tyr Lys Ile Ser Arg Tyr Pro Ala Glu Ile Ala Arg Tyr Lys Met 
    290                 295                 300                 


Ile Lys His Asn Ser Glu Lys Lys Asn Pro Val Asn Arg Cys Arg Tyr 
305                 310                 315                 320 


Lys Leu Met Ser Ala Thr Lys Ser Arg Trp Arg Asn Asp Gly Leu Ser 
                325                 330                 335     


Ser Leu Ser Tyr Asp Leu Ile Ser Leu Gly Arg Leu Pro Leu Tyr Thr 
            340                 345                 350         


His Ile Lys Val Asp Leu Leu Glu Lys Gln Ser Arg Arg Tyr Leu Arg 
        355                 360                 365             


Thr His Gly Phe Pro Thr Cys 
    370                 375 


<210>  75
<211>  1173
<212>  DNA
<213>  Artificial

<220>
<223>  TnGalNAcT(33-421)

<400>  75
atgtcaccgc tgcgtaccta cctgtatacc ccgctgtata atgccaccca accgaccctg     60

cgtaatgtgg aacgtctggc tgcgaactgg ccgaagaaaa ttccgagcaa ctatatcgaa    120

gattcagaag aatactcgat caaaaacatc agtctgtcca atcataccac gcgtgcgagt    180

gtggttcacc cgccgagctc tatcaccgaa acggcctcca aactggacaa aaatatgacc    240

attcaggatg gcgcgttcgc catgattagc ccgaccccgc tgctgatcac gaaactgatg    300

gacagcatta aatcttatgt caccacggaa gatggcgtga agaaagcgga agctgtcgtt    360

accctgccgc tgtgtgactc catgccgcca gatctgggtc cgattaccct gaacaaaacg    420

gaactggaac tggaatgggt tgagaaaaaa tttccggaag tcgaatgggg cggtcgctat    480

agtccgccga actgtaccgc acgtcatcgc gtggctatta tcgttccgta ccgtgaccgc    540

cagcaacacc tggcaatctt tctgaatcac atgcacccgt tcctgatgaa acagcaaatt    600

gaatacggca tttttatcgt ggaacaggaa ggtaataaag atttcaatcg tgcaaaactg    660

atgaacgttg gctttgtcga atctcagaaa ctggtggctg aaggttggca atgctttgtt    720

ttccatgaca tcgatctgct gccgctggat acccgcaatc tgtatagttg tccgcgccag    780

ccgcgtcaca tgtcagccag catcgacaaa ctgcacttta aactgccgta cgaagatatt    840

ttcggcggtg tctcagccat gaccctggaa caatttacgc gtgttaacgg cttctcgaat    900

aaatattggg gttggggcgg tgaagatgac gatatgagct accgcctgaa gaaaattaac    960

tatcatatcg cccgttacaa aatgagcatt gcgcgctatg ccatgctgga ccacaaaaaa   1020

tctaccccga atccgaaacg ttaccagctg ctgagtcaaa ccagcaaaac gtttcagaaa   1080

gatggtctgt ctacgctgga atatgaactg gtccaagttg tgcagtatca tctgtacacg   1140

catattctgg tgaacattga cgaacgctct tga                                1173


<210>  76
<211>  1233
<212>  DNA
<213>  Artificial

<220>
<223>  His-TnGalNAcT(33-421)

<400>  76
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atgtcaccgc tgcgtaccta cctgtatacc ccgctgtata atgccaccca accgaccctg    120

cgtaatgtgg aacgtctggc tgcgaactgg ccgaagaaaa ttccgagcaa ctatatcgaa    180

gattcagaag aatactcgat caaaaacatc agtctgtcca atcataccac gcgtgcgagt    240

gtggttcacc cgccgagctc tatcaccgaa acggcctcca aactggacaa aaatatgacc    300

attcaggatg gcgcgttcgc catgattagc ccgaccccgc tgctgatcac gaaactgatg    360

gacagcatta aatcttatgt caccacggaa gatggcgtga agaaagcgga agctgtcgtt    420

accctgccgc tgtgtgactc catgccgcca gatctgggtc cgattaccct gaacaaaacg    480

gaactggaac tggaatgggt tgagaaaaaa tttccggaag tcgaatgggg cggtcgctat    540

agtccgccga actgtaccgc acgtcatcgc gtggctatta tcgttccgta ccgtgaccgc    600

cagcaacacc tggcaatctt tctgaatcac atgcacccgt tcctgatgaa acagcaaatt    660

gaatacggca tttttatcgt ggaacaggaa ggtaataaag atttcaatcg tgcaaaactg    720

atgaacgttg gctttgtcga atctcagaaa ctggtggctg aaggttggca atgctttgtt    780

ttccatgaca tcgatctgct gccgctggat acccgcaatc tgtatagttg tccgcgccag    840

ccgcgtcaca tgtcagccag catcgacaaa ctgcacttta aactgccgta cgaagatatt    900

ttcggcggtg tctcagccat gaccctggaa caatttacgc gtgttaacgg cttctcgaat    960

aaatattggg gttggggcgg tgaagatgac gatatgagct accgcctgaa gaaaattaac   1020

tatcatatcg cccgttacaa aatgagcatt gcgcgctatg ccatgctgga ccacaaaaaa   1080

tctaccccga atccgaaacg ttaccagctg ctgagtcaaa ccagcaaaac gtttcagaaa   1140

gatggtctgt ctacgctgga atatgaactg gtccaagttg tgcagtatca tctgtacacg   1200

catattctgg tgaacattga cgaacgctct tga                                1233


<210>  77
<211>  1068
<212>  DNA
<213>  Artificial

<220>
<223>  AsGalNAcT(30-383)

<400>  77
atggattact cattctggag cccggcgttc atcatctctg ccccgaaaac cctgaccacc     60

ctgcaaccgt tctctcagtc tacctctacc aacgacctgg cagtctcagc tctggaatcg    120

gtggaattta gcatgctgga taatagctct attctgcatg cgtctgacaa ctggaccaat    180

gatgaactgg tgatgcgcgc ccagaacgaa aatctgcaac tgtgtccgat gacgccgccg    240

gcgctggttg gcccgatcaa agtttggatg gatgcgccga gctttgccga actggaacgt    300

ctgtatccgt tcctggaacc gggcggtcat ggtatgccga ccgcctgtcg tgcacgtcac    360

cgtgttgcca ttgtggttcc gtatcgcgac cgtgaatccc acctgcgcac cttcctgcat    420

aacctgcact cactgctgac gaaacagcaa ctggattacg caatctttgt cgtggaacag    480

accgcaaacg aaacgttcaa tcgtgctaaa ctgatgaatg ttggctatgc ggaagccatt    540

cgcctgtacg attggcgttg ctttatcttc catgacgtcg atctgctgcc ggaagatgac    600

cgcaacctgt attcttgtcc ggacgaaccg cgtcacatga gtgttgcagt cgataaattc    660

aactacaaac tgccgtacgg ttcgattttc ggcggtatca gcgctctgac ccgcgaacaa    720

tttgaaggca ttaacggttt cagcaatgat tactggggct ggggcggtga agatgacgat    780

ctgtcgaccc gtgtgacgct ggcgggttat aaaatcagcc gctacccggc agaaatcgct    840

cgttacaaaa tgatcaaaca taacagtgaa aagaaaaacc cggttaatcg ctgccgttac    900

aaactgatgt ctgccaccaa aagtcgctgg cgtaatgacg gcctgagttc cctgtcctat    960

gatctgattt cactgggtcg cctgccgctg tacacgcaca tcaaagttga cctgctggaa   1020

aaacaatctc gccgctatct gcgtacccac ggcttcccga cctgctga                1068


<210>  78
<211>  1128
<212>  DNA
<213>  Artificial

<220>
<223>  His-AsGalNAcT(30-383)

<400>  78
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat     60

atggattact cattctggag cccggcgttc atcatctctg ccccgaaaac cctgaccacc    120

ctgcaaccgt tctctcagtc tacctctacc aacgacctgg cagtctcagc tctggaatcg    180

gtggaattta gcatgctgga taatagctct attctgcatg cgtctgacaa ctggaccaat    240

gatgaactgg tgatgcgcgc ccagaacgaa aatctgcaac tgtgtccgat gacgccgccg    300

gcgctggttg gcccgatcaa agtttggatg gatgcgccga gctttgccga actggaacgt    360

ctgtatccgt tcctggaacc gggcggtcat ggtatgccga ccgcctgtcg tgcacgtcac    420

cgtgttgcca ttgtggttcc gtatcgcgac cgtgaatccc acctgcgcac cttcctgcat    480

aacctgcact cactgctgac gaaacagcaa ctggattacg caatctttgt cgtggaacag    540

accgcaaacg aaacgttcaa tcgtgctaaa ctgatgaatg ttggctatgc ggaagccatt    600

cgcctgtacg attggcgttg ctttatcttc catgacgtcg atctgctgcc ggaagatgac    660

cgcaacctgt attcttgtcc ggacgaaccg cgtcacatga gtgttgcagt cgataaattc    720

aactacaaac tgccgtacgg ttcgattttc ggcggtatca gcgctctgac ccgcgaacaa    780

tttgaaggca ttaacggttt cagcaatgat tactggggct ggggcggtga agatgacgat    840

ctgtcgaccc gtgtgacgct ggcgggttat aaaatcagcc gctacccggc agaaatcgct    900

cgttacaaaa tgatcaaaca taacagtgaa aagaaaaacc cggttaatcg ctgccgttac    960

aaactgatgt ctgccaccaa aagtcgctgg cgtaatgacg gcctgagttc cctgtcctat   1020

gatctgattt cactgggtcg cctgccgctg tacacgcaca tcaaagttga cctgctggaa   1080

aaacaatctc gccgctatct gcgtacccac ggcttcccga cctgctga                1128


<210>  79
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence W336F, fwd

<400>  79
ctcgaataaa tattggggtt ttggcggtga agatgacgat atg                       43


<210>  80
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence W336F,rev

<400>  80
catatcgtca tcttcaccgc caaaacccca atatttattc gag                       43


<210>  81
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence W336H,fwd

<400>  81
cgaataaata ttggggtcac ggcggtgaag atgacg                               36


<210>  82
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence W336H,rev

<400>  82
cgtcatcttc accgccgtga ccccaatatt tattcg                               36


<210>  83
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence W336V,fwd

<400>  83
cgaataaata ttggggtgtg ggcggtgaag atgacg                               36


<210>  84
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence W336V,rev

<400>  84
cgtcatcttc accgcccaca ccccaatatt tattcg                               36


<210>  85
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence E339A,fwd

<400>  85
gggttggggc ggtgcggatg acgatatgag c                                    31


<210>  86
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence E339A,rev

<400>  86
gctcatatcg tcatccgcac cgccccaacc c                                    31


<210>  87
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence E339G,fwd

<400>  87
gggttggggc ggtggagatg acgatatgag                                      30


<210>  88
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence E339G,rev

<400>  88
ctcatatcgt catctccacc gccccaaccc                                      30


<210>  89
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence E339D,fwd

<400>  89
gggttggggc ggtgatgatg acgatatgag c                                    31


<210>  90
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence E339D,rev

<400>  90
gctcatatcg tcatcatcac cgccccaacc c                                    31


<210>  91
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence I311Y,fwd

<400>  91
gccgtacgaa gattatttcg gcggtgtctc ag                                   32


<210>  92
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence I311Y,rev

<400>  92
ctgagacacc gccgaaataa tcttcgtacg gc                                   32


