                         SEQUENCE LISTING

<110>  WSU Office of Commercialization
 
<120>  RETARGETED AND INSULATED FOAMY VIRUS VECTORS AND METHODS FOR 
       THEIR MANUFACTURE AND USE

<130>  WZZU-11-1001

<140>  PCT/US16/29251
<141>  2016-04-25

<150>  US 62/152,876
<151>  2015-04-25

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  1
tgagcaaaga ccccaacgag                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  2
tcgtccatgc cgagagtgat                                                   20


<210>  3
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  3
ctgcaccacc ggcaa                                                        15


<210>  4
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  4
gtagcggctg aagcactg                                                     18


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-globin-specific primer

<400>  5
atatccccca gtttagtagt tgga                                              24


<210>  6
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-globin-specific primer

<400>  6
ccacaagtat cactaagctc gc                                                22


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-globin-specific primer

<400>  7
cctatcagaa agtggtggct gg                                                22


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-globin-specific primer

<400>  8
ttggacagca agaaagtgag ctt                                               23


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foamy virus LTR primer

<400>  9
accgacttga ttcgagaacc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foamy virus linker primer

<400>  10
gacccgggag atctgaattc                                                   20


<210>  11
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina miSeq platform adaptor sequence


<220>
<221>  misc_feature
<222>  (30)..(36)
<223>  Sample identifier sequence.  "n" indicates at each position any 
       of nucleotides A, C, G, and T.

<220>
<221>  misc_feature
<222>  (37)..(38)
<223>  n is a, c, g, or t

<400>  11
ddaatgatac ggcgaccacc gagatctaca cnnnnnnnac actctttccc tacacgacgc       60

tcttccgatc tgctaaggga gacatct                                           87


<210>  12
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker primer containing a sample identifier miSeq platform 
       adaptor sequence


<220>
<221>  misc_feature
<222>  (25)..(31)
<223>  sample identifier sequence.  "n" indicates at each position any 
       of nucleotides A, C, G, and T.

<400>  12
caagcagaag acggcatacg agatnnnnnn ngtgactgga gttcagacgt gtgctcttcc       60

gatcgatctg aattcagtgg cacag                                             85


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foamy virus 5' LTR sequencing primer

<400>  13
tatgcctccc gctatgctcg                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foamy virus 3' LTR sequencing primer

<400>  14
cctgtggaac acctacatct g                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sequencing primer

<400>  15
taaaccgact tgattcgaga a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cHS4 primer

<400>  16
atattccccc atcctcactg a                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cHS4 insulator PCR primer

<400>  17
gaagaaaaga agcaggcttt c                                                 21


<210>  18
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foamy virus LTR primer containing a sample identifier sequence 
       and an Illumina miSeq platform adaptor sequence


<220>
<221>  misc_feature
<222>  (30)..(36)
<223>  Sample identifier sequence.  "n" indicates at each position any 
       of nucleotides A, C, G, and T.

<400>  18
aatgatacgg cgaccaccga gatctacacn nnnnnnacac tctttcccta cacgacgctc       60

ttccgatctg ctaagggaga catct                                             85


<210>  19
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Foamy virus linker primer containing a sample identifier and an 
       Illumina miSeq platform adaptor


<220>
<221>  misc_feature
<222>  (25)..(31)
<223>  Sample identifier sequence.  "n" indicates at each position any 
       of nucleotides A, C, G, and T.

<400>  19
caagcagaag acggcatacg agatnnnnnn ngtgactgga gttcagacgt gtgctcttcc       60

gatcgatctg aattcagtgg cacag                                             85


<210>  20
<211>  7615
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding a modified Gag CBS-RTY

<400>  20
gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca       60

ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag      120

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca      180

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg      240

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa      300

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta      360

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag      420

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga      480

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac      540

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc      600

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta      660

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac      720

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat      780

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa      840

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg      900

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag      960

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     1020

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     1080

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat     1140

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg     1200

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc     1260

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta     1320

tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg ccacctgacg     1380

cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta     1440

cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt     1500

tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg     1560

ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat     1620

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac     1680

tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag     1740

ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg     1800

cgaattttaa caaaatatta acgcttacaa tttccattcg ccattcaggc tgcgcaactg     1860

ttgggaaggg cgatcggtgc gggcctcttc gctattacgc cagctggcga aagggggatg     1920

tgctgcaagg cgattaagtt gggtaacgcc agggttttcc cagtcacgac gttgtaaaac     1980

gacggccagt gccaagctga tctatacatt gaatcaatat tggcaattag ccatattagt     2040

cattggttat atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata     2100

tcataatatg tacatttata ttggctcatg tccaatatga ccgccatgtt gacattgatt     2160

attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga     2220

gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg     2280

cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg     2340

acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca     2400

tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc     2460

ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat tagtcatcgc     2520

tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc     2580

acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa     2640

tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag     2700

gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc agaattttgt     2760

aatacgactc actatagggc ggccgggaat tcgtcgactg gatccggtac cgaggagatc     2820

tgccgccgcg atcgccatgg cctctggctc taatgtggaa gaatatgaac tggacgttga     2880

agcactggtg gtcatactgc gggataggaa cataccacgg aatcctctcc acggcgaggt     2940

aattggtctg cgactgacag aggggtggtg ggggcagatt gagaggttcc agatggttag     3000

actgatattg cagaacgatg ataatgaacc acttcagaga ccccgctatg aggtcatcca     3060

gagggccgtc aaccctcaca ccatgtttat gatttctgga cctctggccg aactgcagct     3120

cgccttccaa gatctcgatc tgccagaggg ccccttgagg ttcggacccc tggcaaatgg     3180

acattatgtg cagggggacc cctattcctc aagctaccgc ccagtaacaa tggccgagac     3240

cgcacagatg acacgcgacg agctggaaga tgtactcaat actcagagtg agatagagat     3300

acaaatgatt aatctgctgg agctgtatga ggttgagaca agggctctga gaagacagct     3360

cgccgagcgg tctagtactg ggcagggcgg tatctccccg ggagccccaa gatcccggcc     3420

tccagtatcc tcattcagtg gtctgcccag tttgccatct ataccaggca tacatccaag     3480

ggcgccgtcc cccccgaggg ctacatctac ccctggaaat attccctggt ccctgggaga     3540

tgacaatcca cccagctctt cttttcctgg tcctagccaa cccagagtgt cattccaccc     3600

cggcaacccg ttcgtcgaag aagaggggca tagacctaga tcacaaagcc gcgaacgccg     3660

gagagaaatt ctgcccgccc cagtgccttc cgctccacct atgatacagt atatcccagt     3720

gcctccaccg ccacccatcg gcacagtcat ccccatccag cacatcagaa gtgttactgg     3780

ggagccgcct agaaacccac gcgagatccc tatttggctc ggccgcaacg cccctgcgat     3840

tgatggcgtt ttccccgtca ccaccccaga ccttcggtgt cgcataatca atgccattct     3900

gggtggaaac atcggcttga gcttgactcc tggcgattgt ctgacatggg actcagcggt     3960

ggctactctc tttatccgaa cacatgggac cttcccaatg caccagctgg gaaatgtcat     4020

caaggggatc gtggaccaag aaggcgtagc taccgcctat actcttggca tgatgctgtc     4080

cggccaaaat taccagctcg tgtccggcat tatcagggga tacctccctg ggcaagcggt     4140

ggtgaccgcc ctgcagcaac ggctggacca ggagatagac gatcagaccc gcgctgagac     4200

tttcatccag catctgaacg ctgtttacga gatcctcgga ctcaacgcca gaggtcagag     4260

cattcgcgcc agcgtaacgc cacagcctcg gccatcacga gggaggggac gcggtcagaa     4320

taccagtaga ccatctcagg gacctgccaa cagcgggagg ggccggcaga gaccggcctc     4380

aggtcaatcc aaccgcggca gctcaacgca aaaccagaac caggacaacc tgaatcaggg     4440

cgggtacaat ctcagacctg cagcagcaca gcctcagcgc tacgggggtg ggagaggcag     4500

gcggtggaat gataacacca acaatcagga gtcccgacct tctgatcagg gctcacagac     4560

ccctagacca aaccaggccg gatcaggggt ccgcggaaat caatctcaga cccctcgccc     4620

agccgcgggt cgcggcggca ggggaaacca taacaggaac cagcggtcat ccggagctgg     4680

cgatagccga gctgtcaaca cggtaactca gtcagcgacc agctcaacag atgagtcttc     4740

cagcgccgtc acagcggcat caggaggaga ccagcgcgat tagacgcgtt aagcggccgc     4800

actcgaggtt taaacggccg gccgcggtca tagctgtttc ctgaacagat cccgggtggc     4860

atccctgtga cccctcccca gtgcctctcc tggccctgga agttgccact ccagtgccca     4920

ccagccttgt cctaataaaa ttaagttgca tcattttgtc tgactaggtg tccttctata     4980

atattatggg gtggaggggg gtggtatgga gcaaggggca agttgggaag acaacctgta     5040

gggcctgcgg ggtctattgg gaaccaagct ggagtgcagt ggcacaatct tggctcactg     5100

caatctccgc ctcctgggtt caagcgattc tcctgcctca gcctcccgag ttgttgggat     5160

tccaggcatg catgaccagg ctcagctaat ttttgttttt ttggtagaga cggggtttca     5220

ccatattggc caggctggtc tccaactcct aatctcaggt gatctaccca ccttggcctc     5280

ccaaattgct gggattacag gcgtgaacca ctgctccctt ccctgtcctt ctgattttaa     5340

aataactata ccagcaggag gacgtccaga cacagcatag gctacctggc catgcccaac     5400

cggtgggaca tttgagttgc ttgcttggca ctgtcctctc atgcgttggg tccactcagt     5460

agatgcctgt tgaattgggt acgcggccag cttggctgtg gaatgtgtgt cagttagggt     5520

gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat ctcaattagt     5580

cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg caaagcatgc     5640

atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc     5700

cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg     5760

ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc     5820

taggcttttg caaaaagctc ccgggagctt gtatatccat tttcggatct gatcaagaga     5880

cacgtacgac catgaccgag tacaagccca cggtgcgcct cgccacccgc gacgacgtcc     5940

cccgggcagt acgcaccctc gccgccgcgt tcgccgacta ccccgccacg cgccacaccg     6000

tcgatccaga ccgccacatc gagcgggtca ccgagctgca agaactcttc ctcacgcgcg     6060

tcgggctcga catcggcaag gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga     6120

ccacgccgga gagcgtcgaa gcgggggcgg tgttcgccga gatcggcccg cgcatggccg     6180

agttgagcgg ttcccggctg gccgcgcagc aacagatgga aggcctcctg gcgccgcacc     6240

ggcccaagga gcccgcgtgg ttcctggcca ccgtcggcgt ctcgcccgac caccagggca     6300

agggtctggg cagcgccgtc gtgctccccg gagtggaggc ggccgagcgc gccggggtgc     6360

ccgccttcct ggagacctcc gcgccccgca acctcccctt ctacgagcgg ctcggcttca     6420

ccgtcaccgc cgacgtcgag gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc     6480

ccggtgcctg actgcagtgg gactctgggg ttcgaaatga ccgaccaagc gacgcccaac     6540

ctgccatcac gagatttcga ttccaccgcc gccttctatg aaaggttggg cttcggaatc     6600

gttttccggg acgccggctg gatgatcctc cagcgcgggg atctcatgct ggagttcttc     6660

gcccacccca acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca     6720

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc     6780

aatgtatctt atcatgtctg tataccgtcg acctctagct agagcttggc gtaatcatgg     6840

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc     6900

ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg     6960

ttgcgctcac tgcccgcttt ccagtcggga aacctgtcgt gccagctgca ttaatgaatc     7020

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     7080

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     7140

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     7200

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc     7260

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     7320

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     7380

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     7440

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     7500

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     7560

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagca          7615


<210>  21
<211>  1752
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding POL IN-CBX1

<400>  21
tgcaacacca agaaacctaa ccttgacgcc gaattggacc aattgctgca gggacattac       60

ataaagggct accccaagca gtatacctat tttctggaag acggcaaggt aaaagtgtcc      120

cggccagagg gcgtcaagat catcccgcca caaagcgaca gacagaaaat cgttctgcag      180

gcccacaacc tcgctcatac tgggcgcgaa gctactctgc tcaagattgc caatctgtat      240

tggtggccga atatgagaaa agacgtcgta aagcaactgg ggcgctgtca gcagtgtttg      300

atcactaacg caagtaacaa agcaagtggg ccgattcttc gaccagaccg ccctcagaaa      360

ccgttcgata agttttttat agattacatt ggacctctgc ctcccagtca aggctacctc      420

tacgtgctgg tagtggtcga tggcatgacg ggattcacat ggctgtaccc gaccaaggcg      480

ccgagtactt ccgcgacggt caagagcctt aacgttctca cctccatagc tatccccaaa      540

gttatccact ccgaccaggg cgcagctttc accagctcta ccttcgcgga gtgggccaaa      600

gagaggggga ttcacttgga attctcaacg ccttaccacc cccaatctag cggaaaggtc      660

gagagaaaaa attcagatat caaaagactg ttgaccaagc tgcttgttgg ccgccctaca      720

aagtggtatg acctcctgcc tgtcgtccag ctggcactga acaacaccta cagccccgtg      780

ctcaagtata cacctcatca gttgctgttt ggtattgata gtaacactcc tttcgcaaat      840

caggatacgt tggatctcac tcgcgaagaa gagctcagtt tgctgcagga gatacgcacg      900

agtctgtacc acccttccac tcctcccact tctagtaggt cttggtctcc agttgtggga      960

cagcttgttc aggaaagagt cgcccggccc gcatcactgc ggccccggtg gcacaaaccg     1020

tctactgtac tgaaggtgct caacccacgg acggtggtaa tccttgacca tctcggaaac     1080

aaccggacag tgtcaatcga taacctcaag ccaacctccc accaaaacgg cacaaccaat     1140

gacacagcca caatggatca tctagaacag aatgagggta gtggtagcgg ctcaatggga     1200

aagaaacaga acaaaaagaa ggtggaagag gtgctcgagg aggaggaaga agagtatgta     1260

gtggagaagg tgctggacag gcgcgtggtg aaggggaagg tcgaatacct cttgaagtgg     1320

aagggttttt ctgatgaaga caacacgtgg gaacccgagg agaacctgga ttgccccgat     1380

ctgatcgcag agtttctcca gtctcaaaag accgcccacg aaaccgataa gtcagaagga     1440

ggaaaaagaa aagccgactc agatagcgag gataaaggcg aagagtctaa acccaagaaa     1500

aaaaaagagg aatcagaaaa accccgaggg ttcgctcggg gacttgagcc ggaaaggatc     1560

attggcgcca ctgacagttc tggcgagttg atgtttctga tgaagtggaa gaactccgat     1620

gaagccgatc tggtgcccgc caaagaagca aatgttaaat gcccacaggt tgtcattagc     1680

ttttacgaag aacggctgac ttggcatagc tacccgtctg aggatgatga taaaaaggat     1740

gacaagaact aa                                                         1752


<210>  22
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of IN-CBX1

<400>  22

Cys Asn Thr Lys Lys Pro Asn Leu Asp Ala Glu Leu Asp Gln Leu Leu 
1               5                   10                  15      


Gln Gly His Tyr Ile Lys Gly Tyr Pro Lys Gln Tyr Thr Tyr Phe Leu 
            20                  25                  30          


Glu Asp Gly Lys Val Lys Val Ser Arg Pro Glu Gly Val Lys Ile Ile 
        35                  40                  45              


Pro Pro Gln Ser Asp Arg Gln Lys Ile Val Leu Gln Ala His Asn Leu 
    50                  55                  60                  


Ala His Thr Gly Arg Glu Ala Thr Leu Leu Lys Ile Ala Asn Leu Tyr 
65                  70                  75                  80  


Trp Trp Pro Asn Met Arg Lys Asp Val Val Lys Gln Leu Gly Arg Cys 
                85                  90                  95      


Gln Gln Cys Leu Ile Thr Asn Ala Ser Asn Lys Ala Ser Gly Pro Ile 
            100                 105                 110         


Leu Arg Pro Asp Arg Pro Gln Lys Pro Phe Asp Lys Phe Phe Ile Asp 
        115                 120                 125             


Tyr Ile Gly Pro Leu Pro Pro Ser Gln Gly Tyr Leu Tyr Val Leu Val 
    130                 135                 140                 


Val Val Asp Gly Met Thr Gly Phe Thr Trp Leu Tyr Pro Thr Lys Ala 
145                 150                 155                 160 


Pro Ser Thr Ser Ala Thr Val Lys Ser Leu Asn Val Leu Thr Ser Ile 
                165                 170                 175     


Ala Ile Pro Lys Val Ile His Ser Asp Gln Gly Ala Ala Phe Thr Ser 
            180                 185                 190         


Ser Thr Phe Ala Glu Trp Ala Lys Glu Arg Gly Ile His Leu Glu Phe 
        195                 200                 205             


Ser Thr Pro Tyr His Pro Gln Ser Ser Gly Lys Val Glu Arg Lys Asn 
    210                 215                 220                 


Ser Asp Ile Lys Arg Leu Leu Thr Lys Leu Leu Val Gly Arg Pro Thr 
225                 230                 235                 240 


Lys Trp Tyr Asp Leu Leu Pro Val Val Gln Leu Ala Leu Asn Asn Thr 
                245                 250                 255     


Tyr Ser Pro Val Leu Lys Tyr Thr Pro His Gln Leu Leu Phe Gly Ile 
            260                 265                 270         


Asp Ser Asn Thr Pro Phe Ala Asn Gln Asp Thr Leu Asp Leu Thr Arg 
        275                 280                 285             


Glu Glu Glu Leu Ser Leu Leu Gln Glu Ile Arg Thr Ser Leu Tyr His 
    290                 295                 300                 


Pro Ser Thr Pro Pro Thr Ser Ser Arg Ser Trp Ser Pro Val Val Gly 
305                 310                 315                 320 


Gln Leu Val Gln Glu Arg Val Ala Arg Pro Ala Ser Leu Arg Pro Arg 
                325                 330                 335     


Trp His Lys Pro Ser Thr Val Leu Lys Val Leu Asn Pro Arg Thr Val 
            340                 345                 350         


Val Ile Leu Asp His Leu Gly Asn Asn Arg Thr Val Ser Ile Asp Asn 
        355                 360                 365             


Leu Lys Pro Thr Ser His Gln Asn Gly Thr Thr Asn Asp Thr Ala Thr 
    370                 375                 380                 


Met Asp His Leu Glu Gln Asn Glu Gly Ser Gly Ser Gly Ser Met Gly 
385                 390                 395                 400 


Lys Lys Gln Asn Lys Lys Lys Val Glu Glu Val Leu Glu Glu Glu Glu 
                405                 410                 415     


Glu Glu Tyr Val Val Glu Lys Val Leu Asp Arg Arg Val Val Lys Gly 
            420                 425                 430         


Lys Val Glu Tyr Leu Leu Lys Trp Lys Gly Phe Ser Asp Glu Asp Asn 
        435                 440                 445             


Thr Trp Glu Pro Glu Glu Asn Leu Asp Cys Pro Asp Leu Ile Ala Glu 
    450                 455                 460                 


Phe Leu Gln Ser Gln Lys Thr Ala His Glu Thr Asp Lys Ser Glu Gly 
465                 470                 475                 480 


Gly Lys Arg Lys Ala Asp Ser Asp Ser Glu Asp Lys Gly Glu Glu Ser 
                485                 490                 495     


Lys Pro Lys Lys Lys Lys Glu Glu Ser Glu Lys Pro Arg Gly Phe Ala 
            500                 505                 510         


Arg Gly Leu Glu Pro Glu Arg Ile Ile Gly Ala Thr Asp Ser Ser Gly 
        515                 520                 525             


Glu Leu Met Phe Leu Met Lys Trp Lys Asn Ser Asp Glu Ala Asp Leu 
    530                 535                 540                 


Val Pro Ala Lys Glu Ala Asn Val Lys Cys Pro Gln Val Val Ile Ser 
545                 550                 555                 560 


Phe Tyr Glu Glu Arg Leu Thr Trp His Ser Tyr Pro Ser Glu Asp Asp 
                565                 570                 575     


Asp Lys Lys Asp Asp Lys Asn 
            580             


<210>  23
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding insulator 650cHS4

<400>  23
gagctcatgg ggagagcccc ccgccaaagc ccccagggat gtaattgcat tcctcttccg       60

ctagggggca gcagcgagcc gcccggggct ccgctccggt ccggcgctcc ccccgcatcc      120

ccgagccgga gcccgcagcg tgcggggaca gcccgggcac ggggaaggtg gcacgcgatc      180

gctttcctct gaacgcttct cgctgctctt tgagcctgca gacacctggg gggatacggg      240

gaaaaagctt tgtgtctgag cctgcatgtt tgatggtgtc tggatgcaag cagaaggggt      300

ggaagagctt gcctggagag atacagctgg gtcagtagga ctgggacagg cagctggaga      360

attgccatgt agatgttcat acaatcgtca aatcatgaag gctggaaaag ccctccaaga      420

tccccaagac caaccccaac ccacccactg tgcccactgg ccatgtccct cagtgccaca      480

tccccacagt tcttcatcac ctccagggac ggtgaccccc cacctccgtg ggcagctgtg      540

ccactgcagc accgctcttt ggagaaggta aatcttgcta aatccagcct gaccctcccc      600

tggcacaacg taaggccatt atctctcatc ctactccagg acggagtcag tgag            654


<210>  24
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding insulator A1

<400>  24
ccaatcgtgg catatcctct aaactttctt ttcccttcat aaatcctctt tctttttttt       60

ccccctcaca gttttcctga acaggttgac tattaattgt gtctgcttga tgtggacacc      120

aggtggcgct ggacatcaga tttggagagg cagttgtcta gggaaccggg ctctgtgcca      180

gcgcaggagg caggctggct ctcctactcc agggatgctc atccaggaag gaaaggttgc      240

atgctggaca cactaacctt gaagaattct tctgtctctc tcgtcattta gaaaggaagg      300


<210>  25
<211>  268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding insulator A2

<400>  25
tagagcgaga ttccgtctca aagaaaaaaa aagtaatgaa atgaataaaa tgagtcctag       60

agccagtaaa tgtcgtaaat gtctcagcta gtcaggtagt aaaaggtctc aactaggcag      120

tggcagagca ggattcaaat tcagggctgt tgtgatgcct ccgcagactc tgagcgccac      180

ctggtggtaa tttgtctgtg cctcttctga cgtggaagaa cagcaactaa cacactaaca      240

cggcatttac tatgggccag ccattgta                                         268


<210>  26
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding insulator 7xCTF/NF1

<400>  26
ttggctgaat gccaaggaaa gttggctgaa tgccaaaccg acttggctga atgccaatat       60

ttattggctg aatgccaaga ggtattggct gaatgccaat tcatcttggc tgaatgccaa      120

tgattgttgg ctgaatgcca aa                                               142


<210>  27
<211>  472
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding insulator 12xCTCF

<400>  27
gccaaaggaa cgtggttcgt ggccaccagg gggcgcccga accgagtgct acaggttgtg       60

gccaccaggg ggcgcccgtc agaacaatgt ggacttggtg gccaccaggg ggcgcccgtt      120

agggttactc tggagcgtgg ccaccagggg gcgcccgaga gtggtcaaaa tgtccgtggc      180

caccaggggg cgcccgcggt tcagaggagg aggaggtggc caccaggggg cgcccgagat      240

agcgctagag gaaggtggcc accagggggc gcccgtgaga gcatggagag gcagtggcca      300

ccagggggcg cccgctcaag ctggctggcc ctcgtggcca ccagggggcg cccggatgac      360

ctgccctccc tggtggccac cagggggcgc ccgaattcat atccagagtg cgtggccacc      420

agggggcgcc cgcgggagtg gacatggatt tgtggccacc agggggcgcc cg              472


<210>  28
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence encoding insulator 6xCTCF

<400>  28
cccagggatg taattacgtc cctcccccgc tagggggcag cacccaggcc tgcactgccg       60

cctgccggca ggggtccagt ccgcggacct cacacccagg gatgtaatta cgtccctccc      120

ccgctagggg gcagcaccca ggcctgcact gccgcctgcc ggcaggggtc cagtccgcgg      180

aacatcatgc ccagggatgt aattacgtcc ctcccccgct agggggcagc acccaggcct      240

gcactgccgc ctgccggcag gggtccagtc                                       270


