                               SEQUENCE LISTING

<110> MOMENTA PHARMACEUTICALS, INC. 
      BIOFACTURA, INC.
 
<120> METHODS OF MANUFACTURING THERAPEUTIC PROTEINS

<130> M2050-7090WO

<140> PCT/US2016/029472
<141> 2016-04-27

<150> 62/153,178
<151> 2015-04-27

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 341
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Lys Val Val Leu Ile Thr Gly Ala Ser Ser Gly Ile Gly Leu 
1               5                   10                  15      


Ala Leu Cys Lys Arg Leu Leu Ala Glu Asp Asp Glu Leu His Leu Cys 
            20                  25                  30          


Leu Ala Cys Arg Asn Met Ser Lys Ala Glu Ala Val Cys Ala Ala Leu 
        35                  40                  45              


Leu Ala Ser His Pro Thr Ala Glu Val Thr Ile Val Gln Val Asp Val 
    50                  55                  60                  


Ser Asn Leu Gln Ser Val Phe Arg Ala Ser Lys Glu Leu Lys Gln Arg 
65                  70                  75                  80  


Phe Gln Arg Leu Asp Cys Ile Tyr Leu Asn Ala Gly Ile Met Pro Asn 
                85                  90                  95      


Pro Gln Leu Asn Ile Lys Ala Leu Phe Phe Gly Leu Phe Ser Arg Lys 
            100                 105                 110         


Val Ile His Met Phe Ser Thr Ala Glu Gly Leu Leu Thr Gln Gly Asp 
        115                 120                 125             


Lys Ile Thr Ala Asp Gly Leu Gln Glu Val Phe Glu Thr Asn Val Phe 
    130                 135                 140                 


Gly His Phe Ile Leu Ile Arg Glu Leu Glu Pro Leu Leu Cys His Ser 
145                 150                 155                 160 


Asp Asn Pro Ser Gln Leu Ile Trp Thr Ser Ser Arg Ser Ala Arg Lys 
                165                 170                 175     


Ser Asn Phe Ser Leu Glu Asp Phe Gln His Ser Lys Gly Lys Glu Pro 
            180                 185                 190         


Tyr Ser Ser Ser Lys Tyr Ala Thr Asp Leu Leu Ser Val Ala Leu Asn 
        195                 200                 205             


Arg Asn Phe Asn Gln Gln Gly Leu Tyr Ser Asn Val Ala Cys Pro Gly 
    210                 215                 220                 


Thr Ala Leu Thr Asn Leu Thr Tyr Gly Ile Leu Pro Pro Phe Ile Trp 
225                 230                 235                 240 


Thr Leu Leu Met Pro Ala Ile Leu Leu Leu Arg Phe Phe Ala Asn Ala 
                245                 250                 255     


Phe Thr Leu Thr Pro Tyr Asn Gly Thr Glu Ala Leu Val Trp Leu Phe 
            260                 265                 270         


His Gln Lys Pro Glu Ser Leu Asn Pro Leu Ile Lys Tyr Leu Ser Ala 
        275                 280                 285             


Thr Thr Gly Phe Gly Arg Asn Tyr Ile Met Thr Gln Lys Met Asp Leu 
    290                 295                 300                 


Asp Glu Asp Thr Ala Glu Lys Phe Tyr Gln Lys Leu Leu Glu Leu Glu 
305                 310                 315                 320 


Lys His Ile Arg Val Thr Ile Gln Lys Thr Asp Asn Gln Ala Arg Leu 
                325                 330                 335     


Ser Gly Ser Cys Leu 
            340     


<210> 2
<211> 1537
<212> DNA
<213> Homo sapiens

<400> 2
gtactctgat tggtgacggg tgaggcggcc cgaaatcgta ggacttccga aagcagcggc       60

ggcgtttgct tcactgcttg gaagtgtgag tgcgcgaaga tgcgaaaggt ggttttgatc      120

accggggcta gcagtggcat tggcctggcc ctctgcaagc ggctgctggc ggaagatgat      180

gagcttcatc tgtgtttggc gtgcaggaac atgagcaagg cagaagctgt ctgtgctgct      240

ctgctggcct ctcaccccac tgctgaggtc accattgtcc aggtggatgt cagcaacctg      300

cagtcggtct tccgggcctc caaggaactt aagcaaaggt ttcagagatt agactgtata      360

tatctaaatg ctgggatcat gcctaatcca caactaaata tcaaagcact tttctttggc      420

ctcttttcaa gaaaagtgat tcatatgttc tccacagctg aaggcctgct gacccagggt      480

gataagatca ctgctgatgg acttcaggag gtgtttgaga ccaatgtctt tggccatttt      540

atcctgattc gggaactgga gcctctcctc tgtcacagtg acaatccatc tcagctcatc      600

tggacatcat ctcgcagtgc aaggaaatct aatttcagcc tcgaggactt ccagcacagc      660

aaaggcaagg aaccctacag ctcttccaaa tatgccactg accttttgag tgtggctttg      720

aacaggaact tcaaccagca gggtctctat tccaatgtgg cctgtccagg tacagcattg      780

accaatttga catatggaat tctgcctccg tttatatgga cgctgttgat gccggcaata      840

ttgctacttc gcttttttgc aaatgcattc actttgacac catataatgg aacagaagct      900

ctggtatggc ttttccacca aaagcctgaa tctctcaatc ctctgatcaa atatctgagt      960

gccaccactg gctttggaag aaattacatt atgacccaga agatggacct agatgaagac     1020

actgctgaaa aattttatca aaagttactg gaactggaaa agcacattag ggtcactatt     1080

caaaaaacag ataatcaggc caggctcagt ggctcatgcc tataattcca gcactttggg     1140

aggccaaggc agaaggatca cttgagacca ggagttcaag accagcctga gaaacatagt     1200

gagcccttgt ctctacaaaa agaaataaaa ataatagctg ggtgtggtgg catgcgcatg     1260

tagtcccagc tactcagaag gatgaggtgg gaggatctct tgaggctggg aggcagaggt     1320

tgcagtgagc tgagattgtg ccactgcact ccagcctggg tgacagcgag accctgtctc     1380

aaaatatgta tatatttaat atatatataa aaccagagct gacaatgaca ctctggaaca     1440

ttgcatacct tctgtacatt ctggggtaca tggatttcta ctgagttgga taatatgcat     1500

ttgtaataaa ctatgaacta tgaaaaaaaa aaaaaaa                              1537


<210> 3
<211> 373
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Thr Ser Ala Ser Ser His Leu Asn Lys Gly Ile Lys Gln Val 
1               5                   10                  15      


Tyr Met Ser Leu Pro Gln Gly Glu Lys Val Gln Ala Met Tyr Ile Trp 
            20                  25                  30          


Ile Asp Gly Thr Gly Glu Gly Leu Arg Cys Lys Thr Arg Thr Leu Asp 
        35                  40                  45              


Ser Glu Pro Lys Cys Val Glu Glu Leu Pro Glu Trp Asn Phe Asp Gly 
    50                  55                  60                  


Ser Ser Thr Leu Gln Ser Glu Gly Ser Asn Ser Asp Met Tyr Leu Val 
65                  70                  75                  80  


Pro Ala Ala Met Phe Arg Asp Pro Phe Arg Lys Asp Pro Asn Lys Leu 
                85                  90                  95      


Val Leu Cys Glu Val Phe Lys Tyr Asn Arg Arg Pro Ala Glu Thr Asn 
            100                 105                 110         


Leu Arg His Thr Cys Lys Arg Ile Met Asp Met Val Ser Asn Gln His 
        115                 120                 125             


Pro Trp Phe Gly Met Glu Gln Glu Tyr Thr Leu Met Gly Thr Asp Gly 
    130                 135                 140                 


His Pro Phe Gly Trp Pro Ser Asn Gly Phe Pro Gly Pro Gln Gly Pro 
145                 150                 155                 160 


Tyr Tyr Cys Gly Val Gly Ala Asp Arg Ala Tyr Gly Arg Asp Ile Val 
                165                 170                 175     


Glu Ala His Tyr Arg Ala Cys Leu Tyr Ala Gly Val Lys Ile Ala Gly 
            180                 185                 190         


Thr Asn Ala Glu Val Met Pro Ala Gln Trp Glu Phe Gln Ile Gly Pro 
        195                 200                 205             


Cys Glu Gly Ile Ser Met Gly Asp His Leu Trp Val Ala Arg Phe Ile 
    210                 215                 220                 


Leu His Arg Val Cys Glu Asp Phe Gly Val Ile Ala Thr Phe Asp Pro 
225                 230                 235                 240 


Lys Pro Ile Pro Gly Asn Trp Asn Gly Ala Gly Cys His Thr Asn Phe 
                245                 250                 255     


Ser Thr Lys Ala Met Arg Glu Glu Asn Gly Leu Lys Tyr Ile Glu Glu 
            260                 265                 270         


Ala Ile Glu Lys Leu Ser Lys Arg His Gln Tyr His Ile Arg Ala Tyr 
        275                 280                 285             


Asp Pro Lys Gly Gly Leu Asp Asn Ala Arg Arg Leu Thr Gly Phe His 
    290                 295                 300                 


Glu Thr Ser Asn Ile Asn Asp Phe Ser Ala Gly Val Ala Asn Arg Ser 
305                 310                 315                 320 


Ala Ser Ile Arg Ile Pro Arg Thr Val Gly Gln Glu Lys Lys Gly Tyr 
                325                 330                 335     


Phe Glu Asp Arg Arg Pro Ser Ala Asn Cys Asp Pro Phe Ser Val Thr 
            340                 345                 350         


Glu Ala Leu Ile Arg Thr Cys Leu Leu Asn Glu Thr Gly Asp Glu Pro 
        355                 360                 365             


Phe Gln Tyr Lys Asn 
    370             


<210> 4
<211> 8337
<212> DNA
<213> Homo sapiens

<400> 4
gtaaaactat tccccgtgaa ggcggcaggg cagaggtcca gggcgggctt tgctgggagc       60

ctcgggaccc cgggttgggg gccgtggggc ggcacctggc gagctggcgg gtgggcggcg      120

agccgaggct tcccggcctg gcggcaactc gcccctctgc cctcagccct cccggctccg      180

ctcccttccc ccacgccgcc ctgcccctcc cccacgcccc tttctctttc tttctttctt      240

tcccagttcg cttgccccca ccccagcggc gcccgccggg ctcctcgccc aatggccgcg      300

gggcccggga ccgcatcagc tgatcggccc gggctcctgg ccgctgggag ccaatcaggg      360

caccgggggc ggccccgggc cgcggataaa gggtgcgggg ctgctggcgg ctctgcagag      420

tcgagagtgg gagaagagcg gagcgtgtga gcagtactgc ggcctcctct cctctcctaa      480

cctcgctctc gcggcctagc tttacccgcc cgcctgctcg gcgaccagcg gggatcctcc      540

cccagccgca agtccacgaa gaaagcaacg aatgaaaatt atgaagacaa cgagaagtca      600

gactcctccg ggtcgcgctc cagctgcttc ggcttcgtcg cctactctgt gaactccggg      660

gagagatctc gagtcaagat taagacctta acccaccaac ctgcctgttc ggacaccccc      720

cgggccggcc gctgtctgtc cccttctcca tcgccctctc ccagaaagct ccggtgcttg      780

gaccagctag agtctgagaa agaggagagg cgcgaacgcc actccaaaaa gagaagggtt      840

aaagagggca accctaacga tacgcttgac tttctgtggc tgggaacacc ttccaccatg      900

accacctcag caagttccca cttaaataaa ggcatcaagc aggtgtacat gtccctgcct      960

cagggtgaga aagtccaggc catgtatatc tggatcgatg gtactggaga aggactgcgc     1020

tgcaagaccc ggaccctgga cagtgagccc aagtgtgtgg aagagttgcc tgagtggaat     1080

ttcgatggct ctagtacttt acagtctgag ggttccaaca gtgacatgta tctcgtgcct     1140

gctgccatgt ttcgggaccc cttccgtaag gaccctaaca agctggtgtt atgtgaagtt     1200

ttcaagtaca atcgaaggcc tgcagagacc aatttgaggc acacctgtaa acggataatg     1260

gacatggtga gcaaccagca cccctggttt ggcatggagc aggagtatac cctcatgggg     1320

acagatgggc acccctttgg ttggccttcc aacggcttcc cagggcccca gggtccatat     1380

tactgtggtg tgggagcaga cagagcctat ggcagggaca tcgtggaggc ccattaccgg     1440

gcctgcttgt atgctggagt caagattgcg gggactaatg ccgaggtcat gcctgcccag     1500

tgggaatttc agattggacc ttgtgaagga atcagcatgg gagatcatct ctgggtggcc     1560

cgtttcatct tgcatcgtgt gtgtgaagac tttggagtga tagcaacctt tgatcctaag     1620

cccattcctg ggaactggaa tggtgcaggc tgccatacca acttcagcac caaggccatg     1680

cgggaggaga atggtctgaa gtacatcgag gaggccattg agaaactaag caagcggcac     1740

cagtaccaca tccgtgccta tgatcccaag ggaggcctgg acaatgcccg acgtctaact     1800

ggattccatg aaacctccaa catcaacgac ttttctgctg gtgtagccaa tcgtagcgcc     1860

agcatacgca ttccccggac tgttggccag gagaagaagg gttactttga agatcgtcgc     1920

ccctctgcca actgcgaccc cttttcggtg acagaagccc tcatccgcac gtgtcttctc     1980

aatgaaaccg gcgatgagcc cttccagtac aaaaattaag tggactagac ctccagctgt     2040

tgagcccctc ctagttcttc atcccactcc aactcttccc cctctcccag ttgtcccgat     2100

tgtaactcaa agggtggaat atcaaggtcg tttttttcat tccatgtgcc cagttaatct     2160

tgctttcttt gtttggctgg gatagagggg tcaagttatt aatttcttca cacctaccct     2220

cctttttttc cctatcactg aagcttttta gtgcattagt ggggaggagg gtggggagac     2280

ataaccactg cttccattta atggggtgca cctgtccaat aggcgtagct atccggacag     2340

agcacgtttg cagaaggggg tctcttcttc caggtagctg aaaggggaag acctgacgta     2400

ctctggttag gttaggactt gccctcgtgg tggaaacttt tcttaaaaag ttataaccaa     2460

cttttctatt aaaagtggga attaggagag aaggtagggg ttgggaatca gagagaatgg     2520

ctttggtctc ttgcttgtgg gactagcctg gcttgggact aaatgccctg ctctgaacac     2580

gaagcttagt ataaactgat ggatatccct accttgaaag aagaaaaggt tcttactgct     2640

tggtccttga tttatcacac aaagcagaat agtattttta tatttaaatg taaagacaaa     2700

aaactatatg tatggttttg tggattatgt gtgttttgct aaaggaaaaa accatccagg     2760

tcacggggca ccaaatttga gacaaatagt cggattagaa ataaagcatc tcattttgag     2820

tagagagcaa gggaagtggt tcttagatgg tgatctggga ttaggccctc aagacccttt     2880

tgggtttctg ccctgcccac cctctggaga aggtgggcac tggattagtt aacagacaac     2940

acgttactag cagtcacttg atctccgtgg ctttggttta aaagacacac ttgtccacat     3000

aggtttagag ataagagttg gctggtcaac ttgagcatgt tactgacaga gggggtattg     3060

gggttatttt ctggtaggaa tagcatgtca ctaaagcagg ccttttgata ttaaattttt     3120

taaaaagcaa aattatagaa gtttagattt taatcaaatt tgtagggttt ctaggtaatt     3180

tttacagaat tgcttgtttg cttcaactgt ctcctacctc tgctcttgga ggagatgggg     3240

acagggctgg agtcaaaaca cttgtaattt tgtatcttga tgtctttgtt aagactgctg     3300

aagaattatt ttttttcttt tataataagg aataaacccc acctttattc cttcatttca     3360

tctaccattt tctggttctt gtgttggctg tggcaggcca gctgtggttt tcttttgcca     3420

tgacaacttc taattgccat gtacagtatg ttcaaagtca aataactcct cattgtaaac     3480

aaactgtgta actgcccaaa gcagcactta taaatcagcc taacataaga tctctctgat     3540

gtgtttgtga ttctttcaaa tccctatgtg ccattatatt tctttatttc ctaaaacagg     3600

caaaataagc tcaagtttat gtactctgag tttttaaaac actggagtga tgttgctgac     3660

cagccgtttc ctgtacctct ctaagttggg tatttgggac ttaagggatt aagtttttca     3720

cctagactta gttacacaca atcttggcat ttcctagcct agaggtttgt agcagggtac     3780

aagccccact cctccccctt cctttgctcc cctgagtttg gttttggctt accataacat     3840

tgttttgacc attcctagcc taatacaata gcctaacata atgtaagatt aactggcttt     3900

acgatttcta ttctctgctc tcagtgataa gaaacaaata ttagctaccc tgctaccctg     3960

gttgaagcct tccaaggctg gctatgccct aggcatgggc tcatccttgg gtgtatcttg     4020

ccttgcagga agaccagtgg accgattgtg attctcaaaa gctctgtgtt gtcacctgtg     4080

cccttgcccc ttgctcttat cttggtccgt gtatctggga gttcttccac cttatcttgg     4140

ccaattccta ccttcgttca ttcctcatga ggttgggtaa aagctccctc cggctcccat     4200

gatgctgtgc atatacctag caaaaagcaa ttattggaca cattggagtg caatattatt     4260

aatagcatta atactactaa taatgtgggc aatagtgatt gtttttaaaa ggcagtatac     4320

tcttaccagt gcgaggtagc tggggcctgt gatagttttt agagataagt tcttcaggca     4380

actgtgtatt ttacactagt caagtaatcc tagatatccg tggtttttct taagaaagtt     4440

ggctcgtaat atgatttaat attcaaagta gagtcatcta cctattagct tgctggcgtg     4500

gtcctagttt atgcctgttt cagcatgatt gttgagtacc ctgtttcatc cttagcattt     4560

tcttgatttt gttgttaaat gatgtatacc cttatttcca ttgaatctgt gcttccaccc     4620

ccccaactga agttgtcttc cctttgcttg gccaccctta cagcctcttg gatggtgtat     4680

cctacagtgt aagcactaaa ctgaagaggc agtgacctga gcactttgga ttttgttcat     4740

tgtaatcaat tccatgacaa aatgattgca tgagaaggaa ttttaaattc ataggatcag     4800

aatttaggtg aaaacaacca gcatatttgt ttcttcaccc tctcacctag aattagcttt     4860

gacctacagg tcacagtgca atccccttgt atttctaagg tgttttttat agttcatttg     4920

cagacaatgg gttatgtgat aacttttatc agtgatagat taaacagaat aatgaccaag     4980

ctttcaacct taaggagtca ggccagtatt tacaaaagga ggtctccatg aactccttaa     5040

atatgagttc ccctaatatc atcttgccag gtactaaata acaactgata gcacaagcta     5100

tagggaattt gaaagaattc catggatggg tgttgtctag ggccttttgt tgtttttgag     5160

acggggtctg actctcaccc aggctggagt atagtgtggc gcaatcttgg ctcactgcaa     5220

cttctgcctc ccagattcaa gcgattctcc tgcctcagcc tcccaagtag ctgagactac     5280

aggtgtgcac caccatgctc agctaatttt tgtattttta gtacagatgg ggtttcacca     5340

tgttggccag gctggtcttg aactcctgat ctcccaaagt gaggtcttga actggtcttg     5400

aactcctcca cctcccaaag tgctgggatt acaggcgtga gccactgcac ccggcctagg     5460

gccatgtaaa aagccagatc tgtgctgctg tctgtgtaga agggtagaca agtggatgag     5520

aagttcctga actattcttg gcccttttac cactaagtga aagtaacttg ctgccccaaa     5580

gaaagatgtc tcatcattcg acaggacttt ctagttgaac ttcatgaaag caagagatcc     5640

tgtttttctt gctcaccact gtatcttgag acctgttgta gtgcctgcaa tacttattta     5700

ataagttatt tttaagtatc agttttgtga gctttaactc tatgaggtct ttgttgtttg     5760

actgtatttt aactctggcc atgacagcaa gacaaagttc catttttatt gagcttaaaa     5820

agaatcaagg ccaggtgaag tggcttacgc ctgtgatccc aacactttgt gaggctgcag     5880

caggaggatc tcttgagccc aggagtttga gaccgttcta ggcaatgtag tgaggtccag     5940

actccacaaa ataatttttt tttaaattgc acgcctgtag tctcagctat caggaggctg     6000

agatgggagg atgacttgag cccaggaaat tgaagctgca gtgaattgtg attgcaccac     6060

tgcactccag cctgggtgac agatcaagac cttgcctaaa caaaacaaaa caaacaaaac     6120

cccaaaaaac aaattgaaaa tgttgattct ttttactaca aacattatgg cagcactaaa     6180

aacttcgtgg gagtgtactg tggaaaatag tgtacttaat taattctcat tgtaatcagg     6240

ctaccaagag ccttgtgttg ctttaagagt tataactgcc aggcacagtg gctcatgcct     6300

ataatcccag caccttgaga ggccgaggca ggtggatcac ctgagatcgg gagtttgaga     6360

ccagccgggc caatatggtg aaacaagctg tgtctctact aaatacaaaa aattagccgg     6420

gcgtggtggc acatgcctgt aatcccagct gcttgggaga ctgagacagg agaattgctt     6480

gaacctggaa ggcggaggtt gcagtgagct gagattgcaa cattgtactc cagcctgggc     6540

aacaagaggg aaactccatc tcaaaaaaaa aaaaaaagtt gtaactgagg ctgggcatgg     6600

tggctcatac ctgtaatccc agcactttga aaagccgagg caggtagatc acttgagctc     6660

agaagttcga gactagcctg ggcaacatga caaaacccca tctctacaaa aaatacgaaa     6720

aattagctgg gcgtggtggc atgcacctgt agtcctagct acctgggagg ctgaggtggg     6780

aagattactt gaagctgcag tgagccatgg ttgtgccact gccctccagt ctgggcaaca     6840

aagtgagacc ctgtctcaaa aaaacaaaaa aaaattataa ctgatgtaaa ctggcagttt     6900

aggctgggtg tggtggctca agcctgtaat cctagcactt tgggaggcca aggcaggtgg     6960

atcacctgag ttcaggagtt cgagaccagc gtggccaaca tggtgaaacc ttgtctctat     7020

taaaaatacc aaaattagca agatgtggtg gtgggtgcct ataattccag ctactcagga     7080

ggctgaggca ggaggatcgc tggagccagg gaggcagagg ttacagtaag caaagatcac     7140

tccacttcac tccagcctgg gcaaaagagt gagacatatc aaaaaataaa caaataaata     7200

aataaataag tggcagttca tcatttaact ccaaagactt tgcgtacatt tctactgaaa     7260

acaatctgag ctgattagaa ccctgccatt ttatagcctt tagctcgatc tccgaccgtt     7320

catttaaaaa aattctactt caggccgggc atggtggctc aagcctgtaa tcccatcact     7380

gtaggaggcc aaagtgggca gatcacttaa ggtcaggagt ttgagaccag cctggccacc     7440

atggtgaaac cccatctcta ctaaaaatac aaaaattagc cgggcttggt ggtgagcacc     7500

tgtaatccca ccctgccgag tggcaggctg aggcaggaga atcgcttgag cccaagagcc     7560

ggaggttgca gtgagccaag cttgcaccat tgcactccag cctaggcaac agagtgtgac     7620

tccatctcaa gaaaaaaaaa attctatttc attttacaat atgcagatat atgtccatac     7680

acatgcataa tataaatgta taccatattt gtgagaatat gcatatatgt acacattaga     7740

tacacaatac aagcacaata catatgtctt ttgcccaaga tacagcattt tgtaaaggag     7800

acaggaattt agtaatatat gttccagaaa cagtacacaa gagaattcgc cgagatgaga     7860

aagttgtcac taggaatggg gagtggtaag atgtagaagg tataattgtt cttaaagttc     7920

tactgccaac tctttccaat taattaccca ctctgccatg ctttatggac aggaggttgt     7980

cggacactgt caattaataa atatttgagc atgatacact gcttggagct cctctaatat     8040

aggagagtga tatcctagtg catgttacag agggagtgtc cacacagttc ctattgtcat     8100

ttgatgagtt acttttcagg ggccttgtac ctgagcaagt tgtcctcttt ttgatggatt     8160

tcagattgag ttacctgcat tgtcttgaga ttgcagcgtg tttcctccac tgtacggcgt     8220

agtcagcaga tctattagtt aaactccagt gggccctcag tcactaaatc tatcctctgt     8280

gttgaaggct ttctgcattt gcctttcaat aaaggtttag aataactcct taaaaaa        8337


<210> 5
<211> 187
<212> PRT
<213> Homo sapiens

<400> 5
Met Val Gly Ser Leu Asn Cys Ile Val Ala Val Ser Gln Asn Met Gly 
1               5                   10                  15      


Ile Gly Lys Asn Gly Asp Leu Pro Trp Pro Pro Leu Arg Asn Glu Phe 
            20                  25                  30          


Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu Gly Lys Gln 
        35                  40                  45              


Asn Leu Val Ile Met Gly Lys Lys Thr Trp Phe Ser Ile Pro Glu Lys 
    50                  55                  60                  


Asn Arg Pro Leu Lys Gly Arg Ile Asn Leu Val Leu Ser Arg Glu Leu 
65                  70                  75                  80  


Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ser Arg Ser Leu Asp Asp 
                85                  90                  95      


Ala Leu Lys Leu Thr Glu Gln Pro Glu Leu Ala Asn Lys Val Asp Met 
            100                 105                 110         


Val Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala Met Asn His 
        115                 120                 125             


Pro Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln Asp Phe Glu 
    130                 135                 140                 


Ser Asp Thr Phe Phe Pro Glu Ile Asp Leu Glu Lys Tyr Lys Leu Leu 
145                 150                 155                 160 


Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Glu Lys Gly Ile 
                165                 170                 175     


Lys Tyr Lys Phe Glu Val Tyr Glu Lys Asn Asp 
            180                 185         


<210> 6
<211> 3932
<212> DNA
<213> Homo sapiens

<400> 6
tcccagacag aacctactat gtgcggcggc agctggggcg ggaaggcggg agctgggggc       60

gctgggggcg ctgcggccgc tgcggccgct gcagccgctg cagcgccagg gtccacctgg      120

tcggctgcac ctgtggagga ggaggtggat ttcaggcttc ccgtagactg gaagaatcgg      180

ctcaaaaccg cttgcctcgc aggggctgag ctggaggcag cgaggccgcc cgacgcaggc      240

ttccggcgag acatggcagg gcaaggatgg cagcccggcg gcagggcctg gcgaggagcg      300

cgagcccgcg gccgcagttc ccaggcgtct gcgggcgcga gcacgccgcg accctgcgtg      360

cgccggggcg ggggggcggg gcctcgcctg cacaaatggg gacgaggggg gcggggcggc      420

cacaatttcg cgccaaactt gaccgcgcgt tctgctgtaa cgagcgggct cggaggtcct      480

cccgctgctg tcatggttgg ttcgctaaac tgcatcgtcg ctgtgtccca gaacatgggc      540

atcggcaaga acggggacct gccctggcca ccgctcagga atgaattcag atatttccag      600

agaatgacca caacctcttc agtagaaggt aaacagaatc tggtgattat gggtaagaag      660

acctggttct ccattcctga gaagaatcga cctttaaagg gtagaattaa tttagttctc      720

agcagagaac tcaaggaacc tccacaagga gctcattttc tttccagaag tctagatgat      780

gccttaaaac ttactgaaca accagaatta gcaaataaag tagacatggt ctggatagtt      840

ggtggcagtt ctgtttataa ggaagccatg aatcacccag gccatcttaa actatttgtg      900

acaaggatca tgcaagactt tgaaagtgac acgttttttc cagaaattga tttggagaaa      960

tataaacttc tgccagaata cccaggtgtt ctctctgatg tccaggagga gaaaggcatt     1020

aagtacaaat ttgaagtata tgagaagaat gattaatatg aaggtgtttt ctagtttaag     1080

ttgttccccc tccctctgaa aaaagtatgt atttttacat tagaaaaggt tttttgttga     1140

ctttagatct ataattattt ctaagcaact agtttttatt ccccactact cttgtctcta     1200

tcagatacca tttatgagac attcttgcta taactaagtg cttctccaag accccaactg     1260

agtccccagc acctgctaca gtgagctgcc attccacacc catcacatgt ggcactcttg     1320

ccagtccttg acattgtcgg gcttttcaca tgttggtaat atttattaaa gatgaagatc     1380

cacataccct tcaactgagc agtttcacta gtggaaatac caaaagcttc ctacgtgtat     1440

atccagaggt ttgtagataa atgttgccac cttgtttgta acagtgaaaa attgaaaaca     1500

acctggaagt ccagtgatgg gaaaatgagt atgtttctgt cttagattgg ggaacccaaa     1560

gcagattgca agactgaaat ttcagtgaaa gcagtgtatt tgctaggtca taccagaaat     1620

catcaattga ggtacggaga aactgaactg agaaggtaag aaaagcaatt taaagtcagc     1680

gagcaggttc tcattgataa caagctccat actgctgaga tacagggaaa tggagggggg     1740

aaagctggag tattgatccc gcccccctcc ttggttgtca gctccctgtc ctgtgtgtgg     1800

gcggaacata gtccagctgc tctatagcaa gtctcaggtg tttgcagtaa gaagctgctg     1860

gcatgcacgg gaacagtgaa tgccaaacac ttaaagcaat tcgatgttta agtatgtaag     1920

ttcttttttt tttagacagc gtttcgctct tgttgcccag gctagcatgc aatggtgtga     1980

cctcggctta ctgcaacctc cgccttccca gattcaagcg attctcctgc ctcaggctcc     2040

caagtagcta ggaccaggtg cgcgccacca cgcccggcta atttttgtat tttgtatttt     2100

tagtagagat ggggtttcac catgttggtc aggctagtct cgaactcgtg accgcaagcg     2160

attcacccac ctcagcctcc caaagtgctg ggattaccgg cttgagccac cacacccggc     2220

acatcttcat tctttttatg tagtaaaaag tataaggcca cacatggttt atttgaagta     2280

ttttataatt taaaaaaata cagaagcagg aaaaccaatt ataagttcaa gtgagggatg     2340

atggttgctt gaaccaaagg gttgcatgta gtaagaaatt gtgatttaag atatatttta     2400

aagttataag tagcaggata ttctgatgga gtttgacttt ggttttgggc ccagggagtt     2460

tcagatgcct ttgagaaatg aatgaagtag agagaaaata aaagaaaaac cagccaggca     2520

cagtggctca cacctgtaat cccagcgctt tgggaggcta aggcaggcag atcacttgag     2580

accagcttgg gcaacatggc aaagccccat ctctacaaaa aacacaaaaa ttagctgggc     2640

attgtggcgc acacctgtat tcccatctag tcaggaagct gagatggaag aattaattga     2700

gcccacgagt tcaaggctgc agtgagtcgt gattgtgcca ctgcactcca gccggggtga     2760

cagaagagac cttgtctcga aaaggaatct gaaaacaatg gaaccatgcc ttcataattc     2820

tagaaagtta ttttcaactg ataaatctat attcacccaa ataatcaagg gtgaaggtaa     2880

aataatacat ttttagacaa gcaaagactc aggggttacc tccatgtgcc ctttttaggg     2940

aagctgttgg agaaaatact ccagcaaaat gaaggagtac acaaaccaga gaatgacatg     3000

aatccagcaa ataggatcca acacaggcaa tattccagct atggagctag ctttaaaaag     3060

gaacagtaaa aatattaatc ggttagctgg gtggaatggc ccatgcctgt agtcccagct     3120

actcaggagg ctcagcagca ggacgacttg agcccaagag ttccagacca gcctggccac     3180

cttagtgaga tcccttctct taaaaataat aacttattgc cagatttggg gcatttggaa     3240

agaagttcat tgaagataaa gcaaaagtaa aaaaaaaaaa aaaaaaaaca aggggaaagg     3300

gttggttagg caatcattct agggcagaaa gaagtacagg ataggaagag cataatacac     3360

tgtttttctc aacaaggagc agtatgtaca cagtcataat gatgtgactg cttagcccct     3420

aaatatggta actactctgg gacaatatgg gaggaaaagt gaagattgtg atggtgtaag     3480

agctaaatcc tcatctgtca tatccagaaa tcactatata atatataata atgaaatgac     3540

taagttatgt gaggaaaaaa acagaagaca ttgctaaaag agttaaaagt cattgctctg     3600

gagaattagg agggatgggg caggggactg ttaggatgca ttataaactg aaaagccttt     3660

ttaaaatttt atgtattaat atatgcattc acttgaaaaa ctaaaaaaaa acaataattt     3720

ggaaaaaccc atgaaggtaa ctaacggaag gaaaaactaa gagaatgaaa agtatttgcc     3780

tctggaaaga acaactggca ggactgttgt tttcattgta agacttttgg agccatttaa     3840

ttgtacttaa ccattttcat ctatttcttt aataagaaca attccatctt aataaagagt     3900

tacacttgtt aataagtaaa aaaaaaaaaa aa                                   3932


<210> 7
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 7
His His His His His His 
1               5       


