                         SEQUENCE LISTING

<110>  WILLIAM MARSH RICE UNIVERSITY
       TABOR, Jeffrey J.
       SCHMIDL, Sebastian
       SHETH, Ravi
       EKNESS, Felix
       LANDRY, Brian
       DYULGYAROV, Nikola
 
<120>  IDENTIFYING LIGANDS FROM BACTERIAL SENSORS

<130>  Rice:2015-082

<150>  US 62/157,293
<151>  2015-05-05

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  239
<212>  PRT
<213>  E. coli


<220>
<221>  misc_feature
<222>  (1)..(239)
<223>  OmpR (E. coli)

<400>  1

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Ala Phe Gly Lys Phe Lys 
    130                 135                 140                 


Leu Asn Leu Gly Thr Arg Glu Met Phe Arg Glu Asp Glu Pro Met Pro 
145                 150                 155                 160 


Leu Thr Ser Gly Glu Phe Ala Val Leu Lys Ala Leu Val Ser His Pro 
                165                 170                 175     


Arg Glu Pro Leu Ser Arg Asp Lys Leu Met Asn Leu Ala Arg Gly Arg 
            180                 185                 190         


Glu Tyr Ser Ala Met Glu Arg Ser Ile Asp Val Gln Ile Ser Arg Leu 
        195                 200                 205             


Arg Arg Met Val Glu Glu Asp Pro Ala His Pro Arg Tyr Ile Gln Thr 
    210                 215                 220                 


Val Trp Gly Leu Gly Tyr Val Phe Val Pro Asp Gly Ser Lys Ala 
225                 230                 235                 


<210>  2
<211>  234
<212>  PRT
<213>  Synechocystis sp. PCC 6803


<220>
<221>  misc_feature
<222>  (1)..(234)
<223>  CcaR (Synechocystis PCC6803)

<400>  2

Met Arg Ile Leu Leu Val Glu Asp Asp Leu Pro Leu Ala Glu Thr Leu 
1               5                   10                  15      


Ala Glu Ala Leu Ser Asp Gln Leu Tyr Thr Val Asp Ile Ala Thr Asp 
            20                  25                  30          


Ala Ser Leu Ala Trp Asp Tyr Ala Ser Arg Leu Glu Tyr Asp Leu Val 
        35                  40                  45              


Ile Leu Asp Val Met Leu Pro Glu Leu Asp Gly Ile Thr Leu Cys Gln 
    50                  55                  60                  


Lys Trp Arg Ser His Ser Tyr Leu Met Pro Ile Leu Met Met Thr Ala 
65                  70                  75                  80  


Arg Asp Thr Ile Asn Asp Lys Ile Thr Gly Leu Asp Ala Gly Ala Asp 
                85                  90                  95      


Asp Tyr Val Val Lys Pro Val Asp Leu Gly Glu Leu Phe Ala Arg Val 
            100                 105                 110         


Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr Cys Gln Pro Val Leu Glu 
        115                 120                 125             


Trp Gly Pro Ile Arg Leu Asp Pro Ser Thr Tyr Glu Val Ser Tyr Asp 
    130                 135                 140                 


Asn Glu Val Leu Ser Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu 
145                 150                 155                 160 


Leu Leu Arg Asn Gly Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp 
                165                 170                 175     


Ser Ile Trp Lys Leu Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val 
            180                 185                 190         


His Val Arg Ser Leu Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala 
        195                 200                 205             


Asp Ala Ile Glu Thr Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu 
    210                 215                 220                 


Thr Glu Lys Ser Leu Cys Gln Gly Lys Asn 
225                 230                 


<210>  3
<211>  232
<212>  PRT
<213>  Synechocystis sp. PCC 6803


<220>
<221>  misc_feature
<222>  (1)..(232)
<223>  CopR (Synechocystis PCC 6803)

<400>  3

Met Arg Leu Leu Leu Val Glu Asp Glu Pro Asp Leu Gly Met Ala Leu 
1               5                   10                  15      


Glu Lys Ala Leu Arg Arg Glu Asn Tyr Val Val Asp Trp Val Gln Asp 
            20                  25                  30          


Gly Asn Leu Ala Trp Ser Tyr Leu Asp Gln Gly Trp Val Asn Tyr Thr 
        35                  40                  45              


Leu Ala Ile Phe Asp Trp Met Val Pro Gly Leu Ser Gly Leu Glu Leu 
    50                  55                  60                  


Cys Gln Lys Leu Arg Gly Gln Arg Ser Ser Leu Pro Ile Leu Met Leu 
65                  70                  75                  80  


Thr Ala Lys Asp Gln Ile Ala Asp Arg Val Glu Gly Leu Asp Ala Gly 
                85                  90                  95      


Ala Asp Asp Tyr Leu Ile Lys Pro Phe Gly Met Ala Glu Leu Leu Ala 
            100                 105                 110         


Arg Leu Arg Ser Leu Gln Arg Arg Ser Pro Glu Leu Gln Pro Gln Gln 
        115                 120                 125             


Leu Gln Val Gly Gln Trp Trp Leu Asp Tyr Gly Thr Phe Ala Val Val 
    130                 135                 140                 


Thr Pro Glu Gln Ala Arg Ile Thr Leu Thr Ala Lys Glu Phe Gln Leu 
145                 150                 155                 160 


Leu Glu Tyr Phe Met Lys His Pro Gln Gln Ile Leu Ser Ser Glu Gln 
                165                 170                 175     


Ile Lys Asn Gln Leu Trp Ala Leu Ser Ala Glu Ser Thr Ser Asn Val 
            180                 185                 190         


Val Ala Ala Gln Val Arg Leu Leu Arg Arg Lys Leu Glu Glu Tyr Ser 
        195                 200                 205             


His Gly Asn Leu Ile Glu Thr Val Tyr Gly Leu Gly Tyr Arg Phe Gln 
    210                 215                 220                 


Pro His Pro Thr His Ala Glu Gln 
225                 230         


<210>  4
<211>  234
<212>  PRT
<213>  Synechocystis sp. PCC 6803


<220>
<221>  misc_feature
<222>  (1)..(234)
<223>  ManR (Synechocystis PCC6803)

<400>  4

Met Ala Asn Ile Leu Leu Val Asp Asp Glu Asn Ala Leu Thr Glu Pro 
1               5                   10                  15      


Leu Ser Lys Ala Leu Gly His Gln Gly His Thr Ile Asp Val Ala Asp 
            20                  25                  30          


Gln Gly Lys Thr Gly Leu Ala Met Ala Ile Ala Gly Gln Tyr Asp Leu 
        35                  40                  45              


Leu Ile Leu Asp Trp Met Leu Pro Gln Val Ser Gly Leu Glu Ile Cys 
    50                  55                  60                  


Arg Gln Ile Arg Ile Leu Gly His Ser Thr Pro Val Leu Phe Leu Thr 
65                  70                  75                  80  


Ala Lys Asp Thr Leu Asp Asp Arg Val Ala Gly Leu Asp Ala Gly Gly 
                85                  90                  95      


Asp Asp Tyr Leu Ile Lys Pro Phe Glu Leu Arg Glu Leu Leu Ala Arg 
            100                 105                 110         


Val Arg Ala Leu Leu Arg Arg Gln Ser His Gly Glu Thr Ile Thr Glu 
        115                 120                 125             


Thr Leu Gly Ala Val Lys Asn Asn Leu Leu Ser Val Asn Asn Val Ser 
    130                 135                 140                 


Leu Asp Val Ala Asn Gln Val Ala Tyr Cys Gln Gly Gln Arg Ile Ala 
145                 150                 155                 160 


Leu Ser Glu Lys Glu Val Ala Leu Leu Thr Leu Phe Leu Gln Ala Pro 
                165                 170                 175     


Gly Gln Ile Leu Ser His Glu Glu Ile Tyr Ser His Leu Trp Pro Gly 
            180                 185                 190         


Glu Ser Pro Pro Ser Ser Asn Val Leu Ala Ala Leu Val Arg Leu Leu 
        195                 200                 205             


Arg Arg Lys Ile Glu Gln Pro Asn Ala Pro Arg Leu Ile Asn Ser Val 
    210                 215                 220                 


Tyr Gly Lys Gly Tyr Cys Phe Glu Ala Asn 
225                 230                 


<210>  5
<211>  231
<212>  PRT
<213>  B. subtilis


<220>
<221>  misc_feature
<222>  (1)..(231)
<223>  BceR (B. subtilis)

<400>  5

Met Phe Lys Leu Leu Leu Ile Glu Asp Asp Glu Ser Leu Phe His Glu 
1               5                   10                  15      


Ile Lys Asp Arg Leu Thr Gly Trp Ser Tyr Asp Val Tyr Gly Ile Gln 
            20                  25                  30          


Asp Phe Ser Gln Val Leu Gln Glu Phe Ala Ala Val Asn Pro Asp Cys 
        35                  40                  45              


Val Ile Ile Asp Val Gln Leu Pro Lys Phe Asp Gly Phe His Trp Cys 
    50                  55                  60                  


Arg Leu Ile Arg Ser Arg Ser Asn Val Pro Ile Leu Phe Leu Ser Ser 
65                  70                  75                  80  


Arg Asp His Pro Ala Asp Met Val Met Ser Met Gln Leu Gly Ala Asp 
                85                  90                  95      


Asp Phe Ile Gln Lys Pro Phe His Phe Asp Val Leu Ile Ala Lys Ile 
            100                 105                 110         


Gln Ala Met Phe Arg Arg Val His His Tyr Asn Thr Glu Pro Ser Thr 
        115                 120                 125             


Ile Lys Thr Trp Cys Gly Ala Ala Val Asp Ala Glu Gln Asn Leu Val 
    130                 135                 140                 


Ser Asn Asp Lys Gly Ser Val Glu Leu Thr Lys Asn Glu Met Phe Ile 
145                 150                 155                 160 


Leu Lys Gln Leu Ile Glu Gln Lys Asn Lys Ile Val Ser Arg Glu Glu 
                165                 170                 175     


Leu Ile Arg Ser Leu Trp Asn Asp Glu Arg Phe Val Ser Asp Asn Thr 
            180                 185                 190         


Leu Thr Val Asn Val Asn Arg Leu Arg Lys Lys Leu Asp Ala Leu Gln 
        195                 200                 205             


Leu Gly Ala Tyr Ile Glu Thr Lys Val Gly Gln Gly Tyr Ile Ala Lys 
    210                 215                 220                 


Glu Glu Asp Lys Phe Tyr Asp 
225                 230     


<210>  6
<211>  237
<212>  PRT
<213>  B. subtilis


<220>
<221>  misc_feature
<222>  (1)..(237)
<223>  PsdR (B. subtilis)

<400>  6

Met Tyr Arg Ile Leu Leu Val Glu Asp Asp Glu Arg Ile Ala Ser Leu 
1               5                   10                  15      


Leu Gly Gly His Leu Gln Lys Tyr Gly Tyr Glu Val Lys Ile Ala Glu 
            20                  25                  30          


Gln Leu Asn Asp Ile Lys Leu Glu Phe Ala Glu Met Lys Pro Asp Leu 
        35                  40                  45              


Val Leu Leu Asp Ile Asn Leu Pro Phe Phe Asp Gly Phe Tyr Trp Cys 
    50                  55                  60                  


Arg Gln Ile Arg Thr Ile Ser Asn Ala Pro Ile Ile Phe Ile Ser Ala 
65                  70                  75                  80  


Arg Thr Asp Glu Leu Asn Gln Val Met Ala Ile Glu Asn Gly Gly Asp 
                85                  90                  95      


Asp Tyr Ile Thr Lys Pro Phe His Leu Glu Val Val Met Ala Lys Ile 
            100                 105                 110         


Lys Ser Val Leu Arg Arg Thr Tyr Gly Glu Tyr Ser Pro Ser Leu Pro 
        115                 120                 125             


Gln Glu Ser Arg Ile Val Glu Leu Gly Gly Leu Thr Ile Tyr Pro Asp 
    130                 135                 140                 


Gln Asn Glu Ala Glu Trp Asn Ser Val Arg Ile Leu Phe Ser Gln Lys 
145                 150                 155                 160 


Glu Phe Gln Leu Leu Ser Ile Phe Val Arg Glu His Lys Lys Ile Val 
                165                 170                 175     


Ser Arg Asp Glu Leu Leu Glu Ala Leu Trp Asp Asp Val Asp Phe Val 
            180                 185                 190         


Asp Asp Asn Thr Leu Thr Val Asn Val Asn Arg Leu Arg Arg Lys Leu 
        195                 200                 205             


Glu Asn Ala Gly Leu Thr Asp Cys Ile Ser Thr Ile Arg Gly Gln Gly 
    210                 215                 220                 


Tyr Gln Phe Gln Val Asn Arg Lys Asp Glu Ala Glu Cys 
225                 230                 235         


<210>  7
<211>  229
<212>  PRT
<213>  B. subtilis


<220>
<221>  misc_feature
<222>  (1)..(229)
<223>  YxdJ (B. subtilis)

<400>  7

Met Asn Lys Ile Met Ile Val Glu Asp Ser Glu Asp Ile Arg Gly Leu 
1               5                   10                  15      


Leu Gln Asn Tyr Leu Glu Lys Tyr Gly Tyr Gln Thr Val Val Ala Ala 
            20                  25                  30          


Asp Phe Thr Ala Val Leu Asp Val Phe Leu Arg Glu Lys Pro Asp Val 
        35                  40                  45              


Val Leu Leu Asp Ile Asn Leu Pro Ala Tyr Asp Gly Tyr Tyr Trp Cys 
    50                  55                  60                  


Arg Gln Ile Arg Gln His Ser Thr Ser Pro Ile Ile Phe Ile Ser Ala 
65                  70                  75                  80  


Arg Ser Gly Glu Met Asp Gln Val Met Ala Ile Glu Asn Gly Gly Asp 
                85                  90                  95      


Asp Tyr Ile Glu Lys Pro Phe Ser Tyr Asp Ile Val Leu Ala Lys Ile 
            100                 105                 110         


Lys Ser Gln Ile Arg Arg Ala Tyr Gly Glu Tyr Ala Ala Lys Gln Gly 
        115                 120                 125             


Glu Lys Val Val Glu Tyr Ala Gly Val Gln Leu Phe Val Glu Arg Phe 
    130                 135                 140                 


Glu Leu Arg Phe Gln Asp Glu Lys Ser Glu Leu Ser Lys Lys Glu Ser 
145                 150                 155                 160 


Lys Leu Leu Glu Val Leu Leu Glu Arg Gly Glu Lys Val Thr Ser Arg 
                165                 170                 175     


Asp Arg Leu Met Glu Lys Thr Trp Asp Thr Asp Ile Phe Ile Asp Asp 
            180                 185                 190         


Asn Thr Leu Asn Val Tyr Ile Thr Arg Leu Arg Lys Lys Leu Arg Glu 
        195                 200                 205             


Leu Asn Ala Pro Val Ser Ile Glu Ala Val Arg Gly Glu Gly Tyr Gln 
    210                 215                 220                 


Leu Arg Ala Gln Ser 
225                 


<210>  8
<211>  242
<212>  PRT
<213>  B. adolescentis


<220>
<221>  misc_feature
<222>  (1)..(242)
<223>  BAD_0569 (B. adolescentis)

<400>  8

Met Ser Lys Pro Ile Glu Ala Ser Ile Val Val Val Asp Asp Glu Pro 
1               5                   10                  15      


Ser Ile Arg Glu Leu Leu Val Ala Ser Leu His Phe Ala Gly Phe Glu 
            20                  25                  30          


Val Asn Thr Ala Ala Ser Gly Ser Glu Ala Ile Glu Val Ile Glu Arg 
        35                  40                  45              


Leu Gln Pro Asp Leu Ile Val Leu Asp Val Met Leu Pro Asp Ile Asp 
    50                  55                  60                  


Gly Phe Thr Val Thr Arg Arg Ile Arg Gln Glu Gly Ile Thr Thr Pro 
65                  70                  75                  80  


Val Leu Tyr Leu Thr Ala Arg Asp Asp Thr Gln Asp Lys Val Met Gly 
                85                  90                  95      


Leu Thr Val Gly Gly Asp Asp Tyr Val Thr Lys Pro Phe Ser Leu Glu 
            100                 105                 110         


Glu Val Val Ala Arg Ile Arg Ala Ile Leu Arg Arg Thr Gln Gln Gln 
        115                 120                 125             


Val Glu Asp Asp Pro Ile Ile Arg Val Gly Asp Leu Glu Ile Asn Glu 
    130                 135                 140                 


Asp Ser His Asp Val Ser Arg Ala Gly Gln Pro Ile Asp Leu Ser Pro 
145                 150                 155                 160 


Thr Glu Tyr Lys Leu Leu Arg Tyr Leu Met Asp Asn Glu Gly Arg Val 
                165                 170                 175     


Leu Ser Lys Ala Gln Ile Leu Asp His Val Trp Gln Tyr Asp Trp Gly 
            180                 185                 190         


Gly Asp Ala Ala Ile Val Glu Ser Tyr Ile Ser Tyr Leu Arg Lys Lys 
        195                 200                 205             


Val Asp Gly Ile Val Ile Glu Asp Glu Asn Gly Asp Lys His Lys Val 
    210                 215                 220                 


Thr Pro Leu Ile Glu Thr Lys Arg Gly Ile Gly Tyr Met Ile Arg Ala 
225                 230                 235                 240 


Pro Lys 
        


<210>  9
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (122aa)

<400>  9

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gly Cys Ala Thr Cys Gln 
        115                 120                 125             


Pro Val Leu Glu Trp Gly Pro Ile Arg Leu Asp Pro Ser Thr Tyr Glu 
    130                 135                 140                 


Val Ser Tyr Asp Asn Glu Val Leu Ser Leu Thr Arg Lys Glu Tyr Ser 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Leu Arg Asn Gly Arg Arg Val Leu Ser Arg Ser 
                165                 170                 175     


Met Ile Ile Asp Ser Ile Trp Lys Leu Glu Ser Pro Pro Glu Glu Asp 
            180                 185                 190         


Thr Val Lys Val His Val Arg Ser Leu Arg Gln Lys Leu Lys Ser Ala 
        195                 200                 205             


Gly Leu Ser Ala Asp Ala Ile Glu Thr Val His Gly Ile Gly Tyr Arg 
    210                 215                 220                 


Leu Ala Asn Leu Thr Glu Lys Ser Leu Cys Gln Gly Lys Asn 
225                 230                 235             


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (137aa)

<400>  10

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Leu Glu Trp Gly Pro Ile Arg 
    130                 135                 140                 


Leu Asp Pro Ser Thr Tyr Glu Val Ser Tyr Asp Asn Glu Val Leu Ser 
145                 150                 155                 160 


Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly 
                165                 170                 175     


Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu 
            180                 185                 190         


Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu 
        195                 200                 205             


Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr 
    210                 215                 220                 


Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu 
225                 230                 235                 240 


Cys Gln Gly Lys Asn 
                245 


<210>  11
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (138aa)

<400>  11

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Glu Trp Gly Pro Ile Arg 
    130                 135                 140                 


Leu Asp Pro Ser Thr Tyr Glu Val Ser Tyr Asp Asn Glu Val Leu Ser 
145                 150                 155                 160 


Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly 
                165                 170                 175     


Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu 
            180                 185                 190         


Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu 
        195                 200                 205             


Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr 
    210                 215                 220                 


Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu 
225                 230                 235                 240 


Cys Gln Gly Lys Asn 
                245 


<210>  12
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (139aa)

<400>  12

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Ala Trp Gly Pro Ile Arg 
    130                 135                 140                 


Leu Asp Pro Ser Thr Tyr Glu Val Ser Tyr Asp Asn Glu Val Leu Ser 
145                 150                 155                 160 


Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly 
                165                 170                 175     


Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu 
            180                 185                 190         


Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu 
        195                 200                 205             


Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr 
    210                 215                 220                 


Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu 
225                 230                 235                 240 


Cys Gln Gly Lys Asn 
                245 


<210>  13
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (140aa)

<400>  13

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Ala Phe Gly Pro Ile Arg 
    130                 135                 140                 


Leu Asp Pro Ser Thr Tyr Glu Val Ser Tyr Asp Asn Glu Val Leu Ser 
145                 150                 155                 160 


Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly 
                165                 170                 175     


Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu 
            180                 185                 190         


Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu 
        195                 200                 205             


Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr 
    210                 215                 220                 


Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu 
225                 230                 235                 240 


Cys Gln Gly Lys Asn 
                245 


<210>  14
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (142aa)

<400>  14

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Ala Phe Gly Lys Ile Arg 
    130                 135                 140                 


Leu Asp Pro Ser Thr Tyr Glu Val Ser Tyr Asp Asn Glu Val Leu Ser 
145                 150                 155                 160 


Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly 
                165                 170                 175     


Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu 
            180                 185                 190         


Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu 
        195                 200                 205             


Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr 
    210                 215                 220                 


Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu 
225                 230                 235                 240 


Cys Gln Gly Lys Asn 
                245 


<210>  15
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-CcaR (150aa)

<400>  15

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Ile Ala Phe Gly Lys Phe Lys 
    130                 135                 140                 


Leu Asn Leu Gly Thr Arg Glu Val Ser Tyr Asp Asn Glu Val Leu Ser 
145                 150                 155                 160 


Leu Thr Arg Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly 
                165                 170                 175     


Arg Arg Val Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu 
            180                 185                 190         


Glu Ser Pro Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu 
        195                 200                 205             


Arg Gln Lys Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr 
    210                 215                 220                 


Val His Gly Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu 
225                 230                 235                 240 


Cys Gln Gly Lys Asn 
                245 


<210>  16
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-ManR (137aa)

<400>  16

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Leu Ser Val Asn Asn Val Ser 
    130                 135                 140                 


Leu Asp Val Ala Asn Gln Val Ala Tyr Cys Gln Gly Gln Arg Ile Ala 
145                 150                 155                 160 


Leu Ser Glu Lys Glu Val Ala Leu Leu Thr Leu Phe Leu Gln Ala Pro 
                165                 170                 175     


Gly Gln Ile Leu Ser His Glu Glu Ile Tyr Ser His Leu Trp Pro Gly 
            180                 185                 190         


Glu Ser Pro Pro Ser Ser Asn Val Leu Ala Ala Leu Val Arg Leu Leu 
        195                 200                 205             


Arg Arg Lys Ile Glu Gln Pro Asn Ala Pro Arg Leu Ile Asn Ser Val 
    210                 215                 220                 


Tyr Gly Lys Gly Tyr Cys Phe Glu Ala Asn 
225                 230                 


<210>  17
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-PsdR (137aa)

<400>  17

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Val Glu Leu Gly Gly Leu Thr 
    130                 135                 140                 


Ile Tyr Pro Asp Gln Asn Glu Ala Glu Trp Asn Ser Val Arg Ile Leu 
145                 150                 155                 160 


Phe Ser Gln Lys Glu Phe Gln Leu Leu Ser Ile Phe Val Arg Glu His 
                165                 170                 175     


Lys Lys Ile Val Ser Arg Asp Glu Leu Leu Glu Ala Leu Trp Asp Asp 
            180                 185                 190         


Val Asp Phe Val Asp Asp Asn Thr Leu Thr Val Asn Val Asn Arg Leu 
        195                 200                 205             


Arg Arg Lys Leu Glu Asn Ala Gly Leu Thr Asp Cys Ile Ser Thr Ile 
    210                 215                 220                 


Arg Gly Gln Gly Tyr Gln Phe Gln Val Asn Arg Lys Asp Glu Ala Glu 
225                 230                 235                 240 


Cys 
    


<210>  18
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OmpR-YxdJ (137aa)

<400>  18

Met Gln Glu Asn Tyr Lys Ile Leu Val Val Asp Asp Asp Met Arg Leu 
1               5                   10                  15      


Arg Ala Leu Leu Glu Arg Tyr Leu Thr Glu Gln Gly Phe Gln Val Arg 
            20                  25                  30          


Ser Val Ala Asn Ala Glu Gln Met Asp Arg Leu Leu Thr Arg Glu Ser 
        35                  40                  45              


Phe His Leu Met Val Leu Asp Leu Met Leu Pro Gly Glu Asp Gly Leu 
    50                  55                  60                  


Ser Ile Cys Arg Arg Leu Arg Ser Gln Ser Asn Pro Met Pro Ile Ile 
65                  70                  75                  80  


Met Val Thr Ala Lys Gly Glu Glu Val Asp Arg Ile Val Gly Leu Glu 
                85                  90                  95      


Ile Gly Ala Asp Asp Tyr Ile Pro Lys Pro Phe Asn Pro Arg Glu Leu 
            100                 105                 110         


Leu Ala Arg Ile Arg Ala Val Leu Arg Arg Gln Ala Asn Glu Leu Pro 
        115                 120                 125             


Gly Ala Pro Ser Gln Glu Glu Ala Val Val Glu Tyr Ala Gly Val Gln 
    130                 135                 140                 


Leu Phe Val Glu Arg Phe Glu Leu Arg Phe Gln Asp Glu Lys Ser Glu 
145                 150                 155                 160 


Leu Ser Lys Lys Glu Ser Lys Leu Leu Glu Val Leu Leu Glu Arg Gly 
                165                 170                 175     


Glu Lys Val Thr Ser Arg Asp Arg Leu Met Glu Lys Thr Trp Asp Thr 
            180                 185                 190         


Asp Ile Phe Ile Asp Asp Asn Thr Leu Asn Val Tyr Ile Thr Arg Leu 
        195                 200                 205             


Arg Lys Lys Leu Arg Glu Leu Asn Ala Pro Val Ser Ile Glu Ala Val 
    210                 215                 220                 


Arg Gly Glu Gly Tyr Gln Leu Arg Ala Gln Ser 
225                 230                 235 


<210>  19
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CcaR-CopR (137aa)

<400>  19

Met Arg Ile Leu Leu Val Glu Asp Asp Leu Pro Leu Ala Glu Thr Leu 
1               5                   10                  15      


Ala Glu Ala Leu Ser Asp Gln Leu Tyr Thr Val Asp Ile Ala Thr Asp 
            20                  25                  30          


Ala Ser Leu Ala Trp Asp Tyr Ala Ser Arg Leu Glu Tyr Asp Leu Val 
        35                  40                  45              


Ile Leu Asp Val Met Leu Pro Glu Leu Asp Gly Ile Thr Leu Cys Gln 
    50                  55                  60                  


Lys Trp Arg Ser His Ser Tyr Leu Met Pro Ile Leu Met Met Thr Ala 
65                  70                  75                  80  


Arg Asp Thr Ile Asn Asp Lys Ile Thr Gly Leu Asp Ala Gly Ala Asp 
                85                  90                  95      


Asp Tyr Val Val Lys Pro Val Asp Leu Gly Glu Leu Phe Ala Arg Val 
            100                 105                 110         


Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr Cys Gln Pro Val Leu Gln 
        115                 120                 125             


Val Gly Gln Trp Trp Leu Asp Tyr Gly Thr Phe Ala Val Val Thr Pro 
    130                 135                 140                 


Glu Gln Ala Arg Ile Thr Leu Thr Ala Lys Glu Phe Gln Leu Leu Glu 
145                 150                 155                 160 


Tyr Phe Met Lys His Pro Gln Gln Ile Leu Ser Ser Glu Gln Ile Lys 
                165                 170                 175     


Asn Gln Leu Trp Ala Leu Ser Ala Glu Ser Thr Ser Asn Val Val Ala 
            180                 185                 190         


Ala Gln Val Arg Leu Leu Arg Arg Lys Leu Glu Glu Tyr Ser His Gly 
        195                 200                 205             


Asn Leu Ile Glu Thr Val Tyr Gly Leu Gly Tyr Arg Phe Gln Pro His 
    210                 215                 220                 


Pro Thr His Ala Glu Gln 
225                 230 


<210>  20
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CcaR-ManR (137aa)

<400>  20

Met Arg Ile Leu Leu Val Glu Asp Asp Leu Pro Leu Ala Glu Thr Leu 
1               5                   10                  15      


Ala Glu Ala Leu Ser Asp Gln Leu Tyr Thr Val Asp Ile Ala Thr Asp 
            20                  25                  30          


Ala Ser Leu Ala Trp Asp Tyr Ala Ser Arg Leu Glu Tyr Asp Leu Val 
        35                  40                  45              


Ile Leu Asp Val Met Leu Pro Glu Leu Asp Gly Ile Thr Leu Cys Gln 
    50                  55                  60                  


Lys Trp Arg Ser His Ser Tyr Leu Met Pro Ile Leu Met Met Thr Ala 
65                  70                  75                  80  


Arg Asp Thr Ile Asn Asp Lys Ile Thr Gly Leu Asp Ala Gly Ala Asp 
                85                  90                  95      


Asp Tyr Val Val Lys Pro Val Asp Leu Gly Glu Leu Phe Ala Arg Val 
            100                 105                 110         


Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr Cys Gln Pro Val Leu Ser 
        115                 120                 125             


Val Asn Asn Val Ser Leu Asp Val Ala Asn Gln Val Ala Tyr Cys Gln 
    130                 135                 140                 


Gly Gln Arg Ile Ala Leu Ser Glu Lys Glu Val Ala Leu Leu Thr Leu 
145                 150                 155                 160 


Phe Leu Gln Ala Pro Gly Gln Ile Leu Ser His Glu Glu Ile Tyr Ser 
                165                 170                 175     


His Leu Trp Pro Gly Glu Ser Pro Pro Ser Ser Asn Val Leu Ala Ala 
            180                 185                 190         


Leu Val Arg Leu Leu Arg Arg Lys Ile Glu Gln Pro Asn Ala Pro Arg 
        195                 200                 205             


Leu Ile Asn Ser Val Tyr Gly Lys Gly Tyr Cys Phe Glu Ala Asn 
    210                 215                 220             


<210>  21
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CcaR-BceR (137aa)

<400>  21

Met Arg Ile Leu Leu Val Glu Asp Asp Leu Pro Leu Ala Glu Thr Leu 
1               5                   10                  15      


Ala Glu Ala Leu Ser Asp Gln Leu Tyr Thr Val Asp Ile Ala Thr Asp 
            20                  25                  30          


Ala Ser Leu Ala Trp Asp Tyr Ala Ser Arg Leu Glu Tyr Asp Leu Val 
        35                  40                  45              


Ile Leu Asp Val Met Leu Pro Glu Leu Asp Gly Ile Thr Leu Cys Gln 
    50                  55                  60                  


Lys Trp Arg Ser His Ser Tyr Leu Met Pro Ile Leu Met Met Thr Ala 
65                  70                  75                  80  


Arg Asp Thr Ile Asn Asp Lys Ile Thr Gly Leu Asp Ala Gly Ala Asp 
                85                  90                  95      


Asp Tyr Val Val Lys Pro Val Asp Leu Gly Glu Leu Phe Ala Arg Val 
            100                 105                 110         


Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr Cys Gln Pro Val Lys Thr 
        115                 120                 125             


Trp Cys Gly Ala Ala Val Asp Ala Glu Gln Asn Leu Val Ser Asn Asp 
    130                 135                 140                 


Lys Gly Ser Val Glu Leu Thr Lys Asn Glu Met Phe Ile Leu Lys Gln 
145                 150                 155                 160 


Leu Ile Glu Gln Lys Asn Lys Ile Val Ser Arg Glu Glu Leu Ile Arg 
                165                 170                 175     


Ser Leu Trp Asn Asp Glu Arg Phe Val Ser Asp Asn Thr Leu Thr Val 
            180                 185                 190         


Asn Val Asn Arg Leu Arg Lys Lys Leu Asp Ala Leu Gln Leu Gly Ala 
        195                 200                 205             


Tyr Ile Glu Thr Lys Val Gly Gln Gly Tyr Ile Ala Lys Glu Glu Asp 
    210                 215                 220                 


Lys Phe Tyr Asp 
225             


<210>  22
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CcaR-PsdR (137aa)

<400>  22

Met Arg Ile Leu Leu Val Glu Asp Asp Leu Pro Leu Ala Glu Thr Leu 
1               5                   10                  15      


Ala Glu Ala Leu Ser Asp Gln Leu Tyr Thr Val Asp Ile Ala Thr Asp 
            20                  25                  30          


Ala Ser Leu Ala Trp Asp Tyr Ala Ser Arg Leu Glu Tyr Asp Leu Val 
        35                  40                  45              


Ile Leu Asp Val Met Leu Pro Glu Leu Asp Gly Ile Thr Leu Cys Gln 
    50                  55                  60                  


Lys Trp Arg Ser His Ser Tyr Leu Met Pro Ile Leu Met Met Thr Ala 
65                  70                  75                  80  


Arg Asp Thr Ile Asn Asp Lys Ile Thr Gly Leu Asp Ala Gly Ala Asp 
                85                  90                  95      


Asp Tyr Val Val Lys Pro Val Asp Leu Gly Glu Leu Phe Ala Arg Val 
            100                 105                 110         


Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr Cys Gln Pro Val Val Glu 
        115                 120                 125             


Leu Gly Gly Leu Thr Ile Tyr Pro Asp Gln Asn Glu Ala Glu Trp Asn 
    130                 135                 140                 


Ser Val Arg Ile Leu Phe Ser Gln Lys Glu Phe Gln Leu Leu Ser Ile 
145                 150                 155                 160 


Phe Val Arg Glu His Lys Lys Ile Val Ser Arg Asp Glu Leu Leu Glu 
                165                 170                 175     


Ala Leu Trp Asp Asp Val Asp Phe Val Asp Asp Asn Thr Leu Thr Val 
            180                 185                 190         


Asn Val Asn Arg Leu Arg Arg Lys Leu Glu Asn Ala Gly Leu Thr Asp 
        195                 200                 205             


Cys Ile Ser Thr Ile Arg Gly Gln Gly Tyr Gln Phe Gln Val Asn Arg 
    210                 215                 220                 


Lys Asp Glu Ala Glu Cys 
225                 230 


<210>  23
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: CcaR-YxdJ (137aa)

<400>  23

Met Arg Ile Leu Leu Val Glu Asp Asp Leu Pro Leu Ala Glu Thr Leu 
1               5                   10                  15      


Ala Glu Ala Leu Ser Asp Gln Leu Tyr Thr Val Asp Ile Ala Thr Asp 
            20                  25                  30          


Ala Ser Leu Ala Trp Asp Tyr Ala Ser Arg Leu Glu Tyr Asp Leu Val 
        35                  40                  45              


Ile Leu Asp Val Met Leu Pro Glu Leu Asp Gly Ile Thr Leu Cys Gln 
    50                  55                  60                  


Lys Trp Arg Ser His Ser Tyr Leu Met Pro Ile Leu Met Met Thr Ala 
65                  70                  75                  80  


Arg Asp Thr Ile Asn Asp Lys Ile Thr Gly Leu Asp Ala Gly Ala Asp 
                85                  90                  95      


Asp Tyr Val Val Lys Pro Val Asp Leu Gly Glu Leu Phe Ala Arg Val 
            100                 105                 110         


Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr Cys Gln Pro Val Val Glu 
        115                 120                 125             


Tyr Ala Gly Val Gln Leu Phe Val Glu Arg Phe Glu Leu Arg Phe Gln 
    130                 135                 140                 


Asp Glu Lys Ser Glu Leu Ser Lys Lys Glu Ser Lys Leu Leu Glu Val 
145                 150                 155                 160 


Leu Leu Glu Arg Gly Glu Lys Val Thr Ser Arg Asp Arg Leu Met Glu 
                165                 170                 175     


Lys Thr Trp Asp Thr Asp Ile Phe Ile Asp Asp Asn Thr Leu Asn Val 
            180                 185                 190         


Tyr Ile Thr Arg Leu Arg Lys Lys Leu Arg Glu Leu Asn Ala Pro Val 
        195                 200                 205             


Ser Ile Glu Ala Val Arg Gly Glu Gly Tyr Gln Leu Arg Ala Gln Ser 
    210                 215                 220                 


<210>  24
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: BAD_0569-CcaR (137aa)

<400>  24

Met Ser Lys Pro Ile Glu Ala Ser Ile Val Val Val Asp Asp Glu Pro 
1               5                   10                  15      


Ser Ile Arg Glu Leu Leu Val Ala Ser Leu His Phe Ala Gly Phe Glu 
            20                  25                  30          


Val Asn Thr Ala Ala Ser Gly Ser Glu Ala Ile Glu Val Ile Glu Arg 
        35                  40                  45              


Leu Gln Pro Asp Leu Ile Val Leu Asp Val Met Leu Pro Asp Ile Asp 
    50                  55                  60                  


Gly Phe Thr Val Thr Arg Arg Ile Arg Gln Glu Gly Ile Thr Thr Pro 
65                  70                  75                  80  


Val Leu Tyr Leu Thr Ala Arg Asp Asp Thr Gln Asp Lys Val Met Gly 
                85                  90                  95      


Leu Thr Val Gly Gly Asp Asp Tyr Val Thr Lys Pro Phe Ser Leu Glu 
            100                 105                 110         


Glu Val Val Ala Arg Ile Arg Ala Ile Leu Arg Arg Thr Gln Gln Gln 
        115                 120                 125             


Val Glu Asp Asp Pro Val Leu Glu Trp Gly Pro Ile Arg Leu Asp Pro 
    130                 135                 140                 


Ser Thr Tyr Glu Val Ser Tyr Asp Asn Glu Val Leu Ser Leu Thr Arg 
145                 150                 155                 160 


Lys Glu Tyr Ser Ile Leu Glu Leu Leu Leu Arg Asn Gly Arg Arg Val 
                165                 170                 175     


Leu Ser Arg Ser Met Ile Ile Asp Ser Ile Trp Lys Leu Glu Ser Pro 
            180                 185                 190         


Pro Glu Glu Asp Thr Val Lys Val His Val Arg Ser Leu Arg Gln Lys 
        195                 200                 205             


Leu Lys Ser Ala Gly Leu Ser Ala Asp Ala Ile Glu Thr Val His Gly 
    210                 215                 220                 


Ile Gly Tyr Arg Leu Ala Asn Leu Thr Glu Lys Ser Leu Cys Gln Gly 
225                 230                 235                 240 


Lys Asn 
        


<210>  25
<211>  216
<212>  PRT
<213>  E. coli


<220>
<221>  misc_feature
<222>  (1)..(216)
<223>  NarL (E. coli)

<400>  25

Met Ser Asn Gln Glu Pro Ala Thr Ile Leu Leu Ile Asp Asp His Pro 
1               5                   10                  15      


Met Leu Arg Thr Gly Val Lys Gln Leu Ile Ser Met Ala Pro Asp Ile 
            20                  25                  30          


Thr Val Val Gly Glu Ala Ser Asn Gly Glu Gln Gly Ile Glu Leu Ala 
        35                  40                  45              


Glu Ser Leu Asp Pro Asp Leu Ile Leu Leu Asp Leu Asn Met Pro Gly 
    50                  55                  60                  


Met Asn Gly Leu Glu Thr Leu Asp Lys Leu Arg Glu Lys Ser Leu Ser 
65                  70                  75                  80  


Gly Arg Ile Val Val Phe Ser Val Ser Asn His Glu Glu Asp Val Val 
                85                  90                  95      


Thr Ala Leu Lys Arg Gly Ala Asp Gly Tyr Leu Leu Lys Asp Met Glu 
            100                 105                 110         


Pro Glu Asp Leu Leu Lys Ala Leu His Gln Ala Ala Ala Gly Glu Met 
        115                 120                 125             


Val Leu Ser Glu Ala Leu Thr Pro Val Leu Ala Ala Ser Leu Arg Ala 
    130                 135                 140                 


Asn Arg Ala Thr Thr Glu Arg Asp Val Asn Gln Leu Thr Pro Arg Glu 
145                 150                 155                 160 


Arg Asp Ile Leu Lys Leu Ile Ala Gln Gly Leu Pro Asn Lys Met Ile 
                165                 170                 175     


Ala Arg Arg Leu Asp Ile Thr Glu Ser Thr Val Lys Val His Val Lys 
            180                 185                 190         


His Met Leu Lys Lys Met Lys Leu Lys Ser Arg Val Glu Ala Ala Val 
        195                 200                 205             


Trp Val His Gln Glu Arg Ile Phe 
    210                 215     


<210>  26
<211>  196
<212>  PRT
<213>  E. coli


<220>
<221>  misc_feature
<222>  (1)..(196)
<223>  UhpA (E. coli)

<400>  26

Met Ile Thr Val Ala Leu Ile Asp Asp His Leu Ile Val Arg Ser Gly 
1               5                   10                  15      


Phe Ala Gln Leu Leu Gly Leu Glu Pro Asp Leu Gln Val Val Ala Glu 
            20                  25                  30          


Phe Gly Ser Gly Arg Glu Ala Leu Ala Gly Leu Pro Gly Arg Gly Val 
        35                  40                  45              


Gln Val Cys Ile Cys Asp Ile Ser Met Pro Asp Ile Ser Gly Leu Glu 
    50                  55                  60                  


Leu Leu Ser Gln Leu Pro Lys Gly Met Ala Thr Ile Met Leu Ser Val 
65                  70                  75                  80  


His Asp Ser Pro Ala Leu Val Glu Gln Ala Leu Asn Ala Gly Ala Arg 
                85                  90                  95      


Gly Phe Leu Ser Lys Arg Cys Ser Pro Asp Glu Leu Ile Ala Ala Val 
            100                 105                 110         


His Thr Val Ala Thr Gly Gly Cys Tyr Leu Thr Pro Asp Ile Ala Ile 
        115                 120                 125             


Lys Leu Ala Ser Gly Arg Gln Asp Pro Leu Thr Lys Arg Glu Arg Gln 
    130                 135                 140                 


Val Ala Glu Lys Leu Ala Gln Gly Met Ala Val Lys Glu Ile Ala Ala 
145                 150                 155                 160 


Glu Leu Gly Leu Ser Pro Lys Thr Val His Val His Arg Ala Asn Leu 
                165                 170                 175     


Met Glu Lys Leu Gly Val Ser Asn Asp Val Glu Leu Ala Arg Arg Met 
            180                 185                 190         


Phe Asp Gly Trp 
        195     


<210>  27
<211>  213
<212>  PRT
<213>  B. subtilis


<220>
<221>  misc_feature
<222>  (1)..(213)
<223>  YdfI (B. subtilis)

<400>  27

Met Asn Lys Val Leu Ile Val Asp Asp His Leu Val Val Arg Glu Gly 
1               5                   10                  15      


Leu Lys Leu Leu Ile Glu Thr Asn Asp Gln Tyr Thr Ile Ile Gly Glu 
            20                  25                  30          


Ala Glu Asn Gly Lys Val Ala Val Arg Leu Ala Asp Glu Leu Glu Pro 
        35                  40                  45              


Asp Ile Ile Leu Met Asp Leu Tyr Met Pro Glu Met Ser Gly Leu Glu 
    50                  55                  60                  


Ala Ile Lys Gln Ile Lys Glu Lys His Asp Thr Pro Ile Ile Ile Leu 
65                  70                  75                  80  


Thr Thr Tyr Asn Glu Asp His Leu Met Ile Glu Gly Ile Glu Leu Gly 
                85                  90                  95      


Ala Lys Gly Tyr Leu Leu Lys Asp Thr Ser Ser Glu Thr Leu Phe His 
            100                 105                 110         


Thr Met Asp Ala Ala Ile Arg Gly Asn Val Leu Leu Gln Pro Asp Ile 
        115                 120                 125             


Leu Lys Arg Leu Gln Glu Ile Gln Phe Glu Arg Met Lys Lys Gln Arg 
    130                 135                 140                 


Asn Glu Thr Gln Leu Thr Glu Lys Glu Val Ile Val Leu Lys Ala Ile 
145                 150                 155                 160 


Ala Lys Gly Leu Lys Ser Lys Ala Ile Ala Phe Asp Leu Gly Val Ser 
                165                 170                 175     


Glu Arg Thr Val Lys Ser Arg Leu Thr Ser Ile Tyr Asn Lys Leu Gly 
            180                 185                 190         


Ala Asn Ser Arg Thr Glu Ala Val Thr Ile Ala Met Gln Lys Gly Ile 
        195                 200                 205             


Leu Thr Ile Asp Asn 
    210             


<210>  28
<211>  211
<212>  PRT
<213>  B. subtilis


<220>
<221>  misc_feature
<222>  (1)..(211)
<223>  LiaR (B. subtilis)

<400>  28

Met Ile Arg Val Leu Leu Ile Asp Asp His Glu Met Val Arg Met Gly 
1               5                   10                  15      


Leu Ala Ala Phe Leu Glu Ala Gln Pro Asp Ile Glu Val Ile Gly Glu 
            20                  25                  30          


Ala Ser Asp Gly Ser Glu Gly Val Arg Leu Ala Val Glu Leu Ser Pro 
        35                  40                  45              


Asp Val Ile Leu Met Asp Leu Val Met Glu Gly Met Asp Gly Ile Glu 
    50                  55                  60                  


Ala Thr Lys Gln Ile Cys Arg Glu Leu Ser Asp Pro Lys Ile Ile Val 
65                  70                  75                  80  


Leu Thr Ser Phe Ile Asp Asp Asp Lys Val Tyr Pro Val Ile Glu Ala 
                85                  90                  95      


Gly Ala Leu Ser Tyr Leu Leu Lys Thr Ser Lys Ala Ala Glu Ile Ala 
            100                 105                 110         


Asp Ala Ile Arg Ala Ala Ser Lys Gly Glu Pro Lys Leu Glu Ser Lys 
        115                 120                 125             


Val Ala Gly Lys Val Leu Ser Arg Leu Arg His Ser Gly Glu Asn Ala 
    130                 135                 140                 


Leu Pro His Glu Ser Leu Thr Lys Arg Glu Leu Glu Ile Leu Cys Leu 
145                 150                 155                 160 


Ile Ala Glu Gly Lys Thr Asn Lys Glu Ile Gly Glu Glu Leu Phe Ile 
                165                 170                 175     


Thr Ile Lys Thr Val Lys Thr His Ile Thr Asn Ile Leu Ser Lys Leu 
            180                 185                 190         


Asp Val Ser Asp Arg Thr Gln Ala Ala Val Tyr Ala His Arg Asn His 
        195                 200                 205             


Leu Val Asn 
    210     


<210>  29
<211>  209
<212>  PRT
<213>  E. coli


<220>
<221>  misc_feature
<222>  (1)..(209)
<223>  FusR (E. coli)

<400>  29

Met Ile Arg Val Val Leu Val Asp Asp His Val Val Val Arg Ser Gly 
1               5                   10                  15      


Phe Ala Gln Leu Leu Ser Leu Glu Asp Asp Leu Glu Val Ile Gly Gln 
            20                  25                  30          


Tyr Ser Ser Ala Ala Gln Ala Trp Ser Ala Leu Ile Arg Asp Asp Val 
        35                  40                  45              


Asn Val Ala Val Ile Asp Ile Ala Met Pro Asp Glu Asn Gly Leu Ser 
    50                  55                  60                  


Leu Leu Lys Arg Leu Arg Ala Gln Lys Pro Gln Phe Arg Ala Ile Ile 
65                  70                  75                  80  


Leu Ser Ile Tyr Asp Ala Pro Thr Phe Val Gln Ser Ala Leu Asp Ala 
                85                  90                  95      


Gly Ala Ser Gly Tyr Leu Thr Lys Arg Cys Gly Pro Glu Glu Leu Val 
            100                 105                 110         


Gln Ala Val Arg Ser Val Gly Leu Gly Gly His Tyr Leu Cys Ala Asp 
        115                 120                 125             


Ala Ile Arg Ala Leu Arg Gly Gly Gly Gln Pro Ala Gln Ala Leu Glu 
    130                 135                 140                 


Ile Leu Thr Pro Arg Glu Arg Glu Val Phe Glu Leu Leu Val Lys Gly 
145                 150                 155                 160 


Asp Ser Val Lys Glu Ile Ala Phe Lys Leu Glu Leu Ser His Lys Thr 
                165                 170                 175     


Val His Val His Arg Ala Asn Val Leu Gly Lys Leu Asn Cys His Ser 
            180                 185                 190         


Thr Ile Glu Leu Val His Phe Ala Leu Asp His His Leu Leu Ala Gly 
        195                 200                 205             


His 
    


<210>  30
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: NarL-YdfI (131aa)

<400>  30

Met Ser Asn Gln Glu Pro Ala Thr Ile Leu Leu Ile Asp Asp His Pro 
1               5                   10                  15      


Met Leu Arg Thr Gly Val Lys Gln Leu Ile Ser Met Ala Pro Asp Ile 
            20                  25                  30          


Thr Val Val Gly Glu Ala Ser Asn Gly Glu Gln Gly Ile Glu Leu Ala 
        35                  40                  45              


Glu Ser Leu Asp Pro Asp Leu Ile Leu Leu Asp Leu Asn Met Pro Gly 
    50                  55                  60                  


Met Asn Gly Leu Glu Thr Leu Asp Lys Leu Arg Glu Lys Ser Leu Ser 
65                  70                  75                  80  


Gly Arg Ile Val Val Phe Ser Val Ser Asn His Glu Glu Asp Val Val 
                85                  90                  95      


Thr Ala Leu Lys Arg Gly Ala Asp Gly Tyr Leu Leu Lys Asp Met Glu 
            100                 105                 110         


Pro Glu Asp Leu Leu Lys Ala Leu His Gln Ala Ala Ala Gly Glu Met 
        115                 120                 125             


Val Leu Ser Pro Asp Ile Leu Lys Arg Leu Gln Glu Ile Gln Phe Glu 
    130                 135                 140                 


Arg Met Lys Lys Gln Arg Asn Glu Thr Gln Leu Thr Glu Lys Glu Val 
145                 150                 155                 160 


Ile Val Leu Lys Ala Ile Ala Lys Gly Leu Lys Ser Lys Ala Ile Ala 
                165                 170                 175     


Phe Asp Leu Gly Val Ser Glu Arg Thr Val Lys Ser Arg Leu Thr Ser 
            180                 185                 190         


Ile Tyr Asn Lys Leu Gly Ala Asn Ser Arg Thr Glu Ala Val Thr Ile 
        195                 200                 205             


Ala Met Gln Lys Gly Ile Leu Thr Ile Asp Asn 
    210                 215                 


<210>  31
<211>  211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: UhpA-YdfI (131aa)

<400>  31

Met Ile Thr Val Ala Leu Ile Asp Asp His Leu Ile Val Arg Ser Gly 
1               5                   10                  15      


Phe Ala Gln Leu Leu Gly Leu Glu Pro Asp Leu Gln Val Val Ala Glu 
            20                  25                  30          


Phe Gly Ser Gly Arg Glu Ala Leu Ala Gly Leu Pro Gly Arg Gly Val 
        35                  40                  45              


Gln Val Cys Ile Cys Asp Ile Ser Met Pro Asp Ile Ser Gly Leu Glu 
    50                  55                  60                  


Leu Leu Ser Gln Leu Pro Lys Gly Met Ala Thr Ile Met Leu Ser Val 
65                  70                  75                  80  


His Asp Ser Pro Ala Leu Val Glu Gln Ala Leu Asn Ala Gly Ala Arg 
                85                  90                  95      


Gly Phe Leu Ser Lys Arg Cys Ser Pro Asp Glu Leu Ile Ala Ala Val 
            100                 105                 110         


His Thr Val Ala Thr Gly Gly Cys Tyr Leu Thr Pro Asp Ile Leu Lys 
        115                 120                 125             


Arg Leu Gln Glu Ile Gln Phe Glu Arg Met Lys Lys Gln Arg Asn Glu 
    130                 135                 140                 


Thr Gln Leu Thr Glu Lys Glu Val Ile Val Leu Lys Ala Ile Ala Lys 
145                 150                 155                 160 


Gly Leu Lys Ser Lys Ala Ile Ala Phe Asp Leu Gly Val Ser Glu Arg 
                165                 170                 175     


Thr Val Lys Ser Arg Leu Thr Ser Ile Tyr Asn Lys Leu Gly Ala Asn 
            180                 185                 190         


Ser Arg Thr Glu Ala Val Thr Ile Ala Met Gln Lys Gly Ile Leu Thr 
        195                 200                 205             


Ile Asp Asn 
    210     


<210>  32
<211>  208
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: UhpA-LiaR (131aa)

<400>  32

Met Ile Thr Val Ala Leu Ile Asp Asp His Leu Ile Val Arg Ser Gly 
1               5                   10                  15      


Phe Ala Gln Leu Leu Gly Leu Glu Pro Asp Leu Gln Val Val Ala Glu 
            20                  25                  30          


Phe Gly Ser Gly Arg Glu Ala Leu Ala Gly Leu Pro Gly Arg Gly Val 
        35                  40                  45              


Gln Val Cys Ile Cys Asp Ile Ser Met Pro Asp Ile Ser Gly Leu Glu 
    50                  55                  60                  


Leu Leu Ser Gln Leu Pro Lys Gly Met Ala Thr Ile Met Leu Ser Val 
65                  70                  75                  80  


His Asp Ser Pro Ala Leu Val Glu Gln Ala Leu Asn Ala Gly Ala Arg 
                85                  90                  95      


Gly Phe Leu Ser Lys Arg Cys Ser Pro Asp Glu Leu Ile Ala Ala Val 
            100                 105                 110         


His Thr Val Ala Thr Gly Gly Cys Tyr Leu Thr Ser Lys Val Ala Gly 
        115                 120                 125             


Lys Val Leu Ser Arg Leu Arg His Ser Gly Glu Asn Ala Leu Pro His 
    130                 135                 140                 


Glu Ser Leu Thr Lys Arg Glu Leu Glu Ile Leu Cys Leu Ile Ala Glu 
145                 150                 155                 160 


Gly Lys Thr Asn Lys Glu Ile Gly Glu Glu Leu Phe Ile Thr Ile Lys 
                165                 170                 175     


Thr Val Lys Thr His Ile Thr Asn Ile Leu Ser Lys Leu Asp Val Ser 
            180                 185                 190         


Asp Arg Thr Gln Ala Ala Val Tyr Ala His Arg Asn His Leu Val Asn 
        195                 200                 205             


<210>  33
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: FusR-YdfI (129aa)

<400>  33

Met Ile Arg Val Val Leu Val Asp Asp His Val Val Val Arg Ser Gly 
1               5                   10                  15      


Phe Ala Gln Leu Leu Ser Leu Glu Asp Asp Leu Glu Val Ile Gly Gln 
            20                  25                  30          


Tyr Ser Ser Ala Ala Gln Ala Trp Ser Ala Leu Ile Arg Asp Asp Val 
        35                  40                  45              


Asn Val Ala Val Ile Asp Ile Ala Met Pro Asp Glu Asn Gly Leu Ser 
    50                  55                  60                  


Leu Leu Lys Arg Leu Arg Ala Gln Lys Pro Gln Phe Arg Ala Ile Ile 
65                  70                  75                  80  


Leu Ser Ile Tyr Asp Ala Pro Thr Phe Val Gln Ser Ala Leu Asp Ala 
                85                  90                  95      


Gly Ala Ser Gly Tyr Leu Thr Lys Arg Cys Gly Pro Glu Glu Leu Val 
            100                 105                 110         


Gln Ala Val Arg Ser Val Gly Leu Gly Gly His Tyr Leu Gln Pro Asp 
        115                 120                 125             


Ile Leu Lys Arg Leu Gln Glu Ile Gln Phe Glu Arg Met Lys Lys Gln 
    130                 135                 140                 


Arg Asn Glu Thr Gln Leu Thr Glu Lys Glu Val Ile Val Leu Lys Ala 
145                 150                 155                 160 


Ile Ala Lys Gly Leu Lys Ser Lys Ala Ile Ala Phe Asp Leu Gly Val 
                165                 170                 175     


Ser Glu Arg Thr Val Lys Ser Arg Leu Thr Ser Ile Tyr Asn Lys Leu 
            180                 185                 190         


Gly Ala Asn Ser Arg Thr Glu Ala Val Thr Ile Ala Met Gln Lys Gly 
        195                 200                 205             


Ile Leu Thr Ile Asp Asn 
    210                 


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Figure 2 - CcaR

<400>  34

Glu Leu Phe Ala Arg Val Arg Ala Leu Leu Arg Arg Gly Cys Ala Thr 
1               5                   10                  15      


Cys Gln Pro Val Leu Glu Trp Gly Pro Ile Arg Leu Asp 
            20                  25                  


<210>  35
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Figure 2 -  BAD_0568

<400>  35

Glu Val Val Ala Arg Ile Arg Ala Ile Leu Arg Arg Thr Gln Gln Gln 
1               5                   10                  15      


Val Glu Asp Asp Pro Ile Ile Arg Val Gly Asp Leu Glu Ile Asn 
            20                  25                  30      


<210>  36
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Figure 6 sequence

<400>  36

Met Arg Arg Leu Arg Phe Ser Pro Arg Ser Ser Phe Ala Arg Thr Leu 
1               5                   10                  15      


Leu Leu Ile Val Thr Leu Leu Phe Ala Ser Leu Val Thr Thr Tyr Leu 
            20                  25                  30          


Val Val Leu Asn Phe Ala Ile Leu Pro Ser Leu Gln Gln Phe Asn Lys 
        35                  40                  45              


Val Leu Ala Tyr Glu Val Arg Met Leu Met Thr Asp Lys Leu Gln Leu 
    50                  55                  60                  


Glu Asp Gly Thr Gln Leu Val Val Pro Pro Ala Phe Arg Arg Glu Ile 
65                  70                  75                  80  


Tyr Arg Glu Leu Gly Ile Ser Leu Tyr Ser Asn Glu Ala Ala Glu Glu 
                85                  90                  95      


Ala Gly Leu Arg Trp Ala Gln His Tyr Glu Phe Leu Ser His Gln Met 
            100                 105                 110         


Ala Gln Gln Leu Gly Gly Pro Thr Glu Val Arg Val Glu Val Asn Lys 
        115                 120                 125             


Ser Ser Pro Val Val Trp Leu Lys Thr Trp Leu Ser Pro Asn Ile Trp 
    130                 135                 140                 


Val Arg Val Pro Leu Thr Glu Ile His Gln Gly Asp Phe Ser Pro Leu 
145                 150                 155                 160 


Phe Arg Tyr Thr Leu Ala Ile Met Leu Leu Ala Ile Gly Gly Ala Trp 
                165                 170                 175     


Leu Phe Ile Arg Ile Gln Asn Arg Pro Leu Val Asp Leu Glu His Ala 
            180                 185                 190         


Ala Leu Gln Val Gly Lys Gly Ile Ile Pro Pro Pro Leu Arg Glu Tyr 
        195                 200                 205             


Gly Ala Ser Glu Val Arg Ser Val Thr Arg Ala Phe Asn His Met Ala 
    210                 215                 220                 


Ala Gly Val Lys Gln Leu Ala Asp Asp Arg Thr Leu Leu Met Ala Gly 
225                 230                 235                 240 


Val Ser His Asp Leu Arg Thr Pro Leu Thr Arg Ile Arg Leu Ala Thr 
                245                 250                 255     


Glu Met Met Ser Glu Gln Asp Gly Tyr Leu Ala Glu Ser Ile Asn Lys 
            260                 265                 270         


Asp Ile Glu Glu Cys Asn Ala Ile Ile Glu Gln Phe Ile Asp Tyr Leu 
        275                 280                 285             


Arg Thr Gly Gln Glu Met Pro Met Glu Met Ala Asp Leu Asn Ala Val 
    290                 295                 300                 


Leu Gly Glu Val Ile Ala Ala Glu Ser Gly Tyr Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Thr Ala Leu Tyr Pro Gly Ser Ile Glu Val Lys Met His Pro Leu Ser 
                325                 330                 335     


Ile Lys Arg Ala Val Ala Asn Met Val Val Asn Ala Ala Arg Tyr Gly 
            340                 345                 350         


Asn Gly Trp Ile Lys Val Ser Ser Gly Thr Glu Pro Asn Arg Ala Trp 
        355                 360                 365             


Phe Gln Val Glu Asp Asp Gly Pro Gly Ile Ala Pro Glu Gln Arg Lys 
    370                 375                 380                 


His Leu Phe Gln Pro Phe Val Arg Gly Asp Ser Ala Arg Thr Ile Ser 
385                 390                 395                 400 


Gly Thr Gly Leu Gly Leu Ala Ile Val Gln Arg Ile Val Asp Asn His 
                405                 410                 415     


Asn Gly Met Leu Glu Leu Gly Thr Ser Glu Arg Gly Gly Leu Ser Ile 
            420                 425                 430         


Arg Ala Trp Leu Pro Val Pro Val Thr Arg Ala Gln Gly Thr Thr Lys 
        435                 440                 445             


Glu Gly 
    450 


<210>  37
<211>  593
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Figure 6 BAD_0569

<400>  37

Met Gln Pro Pro Arg Ser Leu Pro Lys Gln Asn Lys Val Trp Ser Arg 
1               5                   10                  15      


Phe Thr Arg Arg Ile Gln Ala Ile Pro Leu Ser Thr Lys Leu Val Thr 
            20                  25                  30          


Cys Ile Ile Val Leu Leu Thr Ile Gly Thr Ile Gly Ile Ser Phe Ser 
        35                  40                  45              


Ile Arg Thr Leu Val Gly Asn Tyr Leu Leu Gln Lys Thr Asp Thr Gln 
    50                  55                  60                  


Leu Ile Asn Gln Ala Gln Leu Ile Phe Asn Ser Met Asp Ser Leu Ser 
65                  70                  75                  80  


Ser Asp Thr Gly Asp Asp Gly Arg Ser Leu Met Asn Thr Tyr Tyr Val 
                85                  90                  95      


Glu Val Arg Asp Ser Glu Tyr Lys Ser Thr Gly Ala Gly Ser Val Pro 
            100                 105                 110         


Met Leu Arg Asp Gly Val Val Ser Glu Pro Ser Leu Pro Ala Asp Gly 
        115                 120                 125             


Ser Ile Asp Gly Val Thr Leu Gly Gln Pro Phe Thr Thr Arg Ala Val 
    130                 135                 140                 


Val His Ile Thr Thr Ser Arg Thr Pro Asp His Ser Ile Met Gln Ala 
145                 150                 155                 160 


Ala Gln Ser Pro Trp Arg Val Val Ala Leu Pro Trp Asn Glu Lys Thr 
                165                 170                 175     


Arg Thr Gly Gln Val Lys Asp Ser Gly Val Val Phe Ile Gly Leu Ser 
            180                 185                 190         


Leu Ser Asp Gln Ile Asp Thr Ala Asn Thr Leu Thr Arg Phe Cys Ala 
        195                 200                 205             


Met Val Gly Ile Ala Val Val Leu Ile Gly Ala Ile Leu Gly Thr Ile 
    210                 215                 220                 


Leu Val Gln Ser Thr Leu Ala Pro Leu Lys Arg Ile Glu Lys Thr Ala 
225                 230                 235                 240 


Ala Lys Ile Ala Ala Gly Asp Leu Ser Gln Arg Val Pro Asp Leu Pro 
                245                 250                 255     


Glu Ser Thr Glu Val Gly Ser Leu Ser Met Ser Leu Asn Thr Met Leu 
            260                 265                 270         


Thr Arg Ile Glu Glu Ser Phe His Ala Gln Glu Glu Thr Thr Glu Lys 
        275                 280                 285             


Met Lys Arg Phe Val Ser Asp Ala Ser His Glu Leu Arg Thr Pro Leu 
    290                 295                 300                 


Ala Ala Ile His Gly Tyr Ala Glu Leu Tyr Lys Met Gln Arg Asp Met 
305                 310                 315                 320 


Pro Gly Ala Leu Glu Arg Ala Asp Glu Ser Ile Glu His Ile Glu Ala 
                325                 330                 335     


Ser Ser Ala Arg Met Thr Val Leu Val Glu Asp Leu Leu Ser Leu Ala 
            340                 345                 350         


Arg Leu Asp Glu Gly Arg Gly Ile Asp Ile Thr Gln Gln Val Lys Leu 
        355                 360                 365             


Thr Ser Val Val Arg Asp Ala Ala Asp Asp Leu His Ala Leu Asp Pro 
    370                 375                 380                 


Asp Arg Gly Ile Ser Cys Gly Gln Val Val Leu Gln Pro Gly Thr Asp 
385                 390                 395                 400 


Met Asp His Pro Ala Gln Phe Ala Phe Gln Asn Gly Gln Met Pro Gln 
                405                 410                 415     


Ile Glu Leu Lys Gly Asp Ala Ser Arg Leu Arg Gln Val Val Thr Asn 
            420                 425                 430         


Ile Val Gly Asn Ile His Arg Tyr Thr Pro Ala Asp Ser Pro Val Glu 
        435                 440                 445             


Ile Ser Met Gly Val Leu Pro Ala Ser Ile Ser Pro Glu Ser Leu Ser 
    450                 455                 460                 


Arg Met Pro Ser Asn Glu Gln Ser Leu Arg His Leu Val Glu Ala Ile 
465                 470                 475                 480 


Glu Val Gly Gln Ser Met Gln Val Gly Met Asn Tyr Ala Ile Val Arg 
                485                 490                 495     


Phe Ser Asp His Gly Pro Gly Val Pro Pro Glu Ala Arg Ser Lys Ile 
            500                 505                 510         


Phe Glu Arg Phe Tyr Thr Ala Asp Pro Ser Arg Ala Arg Gln Lys Gly 
        515                 520                 525             


Gly Thr Gly Leu Gly Met Ala Ile Ala Gln Ser Val Val Lys Ala His 
    530                 535                 540                 


His Gly Phe Ile Cys Ala Ser Gly Ser Glu Gly Thr Gly Leu Ile Leu 
545                 550                 555                 560 


Thr Val Val Leu Pro Ile Ala Pro Val Glu Pro Lys Pro Gln Pro Ile 
                565                 570                 575     


Thr Ala Ser Glu Asn Arg Lys Asn Glu Lys Lys Asn Arg Lys Ser Lys 
            580                 585                 590         


Lys 
    


