                         SEQUENCE LISTING

<110>  Koninklijke Philips N.V.
 
<120>  Methods of prostate cancer prognosis

<130>  P14144 2014PF00611

<160>  204   

<170>  PatentIn version 3.5

<210>  1
<211>  7979
<212>  DNA
<213>  Homo sapiens

<400>  1
cagcagcagg ctcagacctg cttccctgga catttccggg accgtgagcg agggaaccac       60

gttgccctgg attcttgcca gctgtacaaa gttgaccagg aaaatggctc agcagacaag      120

cccggacact ttaacagtac ctgaagtgga taatccgcat tgtccaaacc cgtggctgaa      180

cgaagacctt gtgaaatcct tgcgagaaaa cctgttgcag catgagaagt ccaagacagc      240

gaggaaatcg gtttctccca agctctctcc agtgatctct ccgagaaatt cccccaggct      300

tctgcgcaga atgcttctca gcagcaacat ccccaaacag cggcgtttca cggtggcaca      360

tacatgtttt gatgtggaca atggcacatc tgcgggacgg agtcccttgg atcccatgac      420

cagcccagga tccgggctaa ttctccaagc aaattttgtc cacagtcaac gacgggagtc      480

cttcctgtat cgatccgaca gcgattatga cctctctcca aagtctatgt cccggaactc      540

ctccattgcc agtgatatac acggagatga cttgattgtg actccatttg ctcaggtctt      600

ggccagtctg cgaactgtac gaaacaactt tgctgcatta actaatttgc aagatcgagc      660

acctagcaaa agatcaccca tgtgcaacca accatccatc aacaaagcca ccataacaga      720

ggaggcctac cagaaactgg ccagcgagac cctggaggag ctggactggt gtctggacca      780

gctagagacc ctacagacca ggcactccgt cagtgagatg gcctccaaca agtttaaaag      840

gatgcttaat cgggagctca cccatctctc tgaaatgagt cggtctggaa atcaagtgtc      900

agagtttata tcaaacacat tcttagataa gcaacatgaa gtggaaattc cttctccaac      960

tcagaaggaa aaggagaaaa agaaaagacc aatgtctcag atcagtggag tcaagaaatt     1020

gatgcacagc tctagtctga ctaattcaag tatcccaagg tttggagtta aaactgaaca     1080

agaagatgtc cttgccaagg aactagaaga tgtgaacaaa tggggtcttc atgttttcag     1140

aatagcagag ttgtctggta accggccctt gactgttatc atgcacacca tttttcagga     1200

acgggattta ttaaaaacat ttaaaattcc agtagatact ttaattacat atcttatgac     1260

tctcgaagac cattaccatg ctgatgtggc ctatcacaac aatatccatg ctgcagatgt     1320

tgtccagtct actcatgtgc tattatctac acctgctttg gaggctgtgt ttacagattt     1380

ggagattctt gcagcaattt ttgccagtgc aatacatgat gtagatcatc ctggtgtgtc     1440

caatcaattt ctgatcaata caaactctga acttgccttg atgtacaatg attcctcagt     1500

cttagagaac catcatttgg ctgtgggctt taaattgctt caggaagaaa actgtgacat     1560

tttccagaat ttgaccaaaa aacaaagaca atctttaagg aaaatggtca ttgacatcgt     1620

acttgcaaca gatatgtcaa aacacatgaa tctactggct gatttgaaga ctatggttga     1680

aactaagaaa gtgacaagct ctggagttct tcttcttgat aattattccg ataggattca     1740

ggttcttcag aatatggtgc actgtgcaga tctgagcaac ccaacaaagc ctctccagct     1800

gtaccgccag tggacggacc ggataatgga ggagttcttc cgccaaggag accgagagag     1860

ggaacgtggc atggagataa gccccatgtg tgacaagcac aatgcttccg tggaaaaatc     1920

acaggtgggc ttcatagact atattgttca tcccctctgg gagacatggg cagacctcgt     1980

ccaccctgac gcccaggata ttttggacac tttggaggac aatcgtgaat ggtaccagag     2040

cacaatccct cagagcccct ctcctgcacc tgatgaccca gaggagggcc ggcagggtca     2100

aactgagaaa ttccagtttg aactaacttt agaggaagat ggtgagtcag acacggaaaa     2160

ggacagtggc agtcaagtgg aagaagacac tagctgcagt gactccaaga ctctttgtac     2220

tcaagactca gagtctactg aaattcccct tgatgaacag gttgaagagg aggcagtagg     2280

ggaagaagag gaaagccagc ctgaagcctg tgtcatagat gatcgttctc ctgacacgta     2340

acagtgcaaa aactttcatg cctttttttt ttttaagtag aaaaattgtt tccaaagtgc     2400

atgtcacatg ccacaaccac ggtcacacct cactgtcatc tgccaggacg tttgttgaac     2460

aaaactgacc ttgactactc agtccagcgc tcaggaatat cgtaaccagt tttttcacct     2520

ccatgtcatc cgagcaaggt ggacatcttc acgaacagcg tttttaacaa gatttcagct     2580

tggtagagct gacaaagcag ataaaatcta ctccaaatta ttttcaagag agtgtgactc     2640

atcaggcagc ccaaaagttt attggacttg gggtttctat tcctttttat ttgtttgcaa     2700

tattttcaga agaaaggcat tgcacagagt gaacttaatg gacgaagcaa caaatatgtc     2760

aagaacagga catagcacga atctgttacc agtaggagga ggatgagcca cagaaattgc     2820

ataattttct aatttcaagt cttcctgata catgactgaa tagtgtggtt cagtgagctg     2880

cactgacctc tacattttgt atgatatgta aaacagattt tttgtagagc ttacttttat     2940

tattaaatgt attgaggtat tatatttaaa aaaaactatg ttcagaactt catctgccac     3000

tggttatttt tttctaagga gtaacttgca agttttcagt acaaatctgt gctacactgg     3060

ataaaaatct aatttatgaa ttttacttgc accttatagt tcatagcaat taactgattt     3120

gtagtgattc attgtttgtt ttatatacca atgacttcca tattttaaaa gagaaaaaca     3180

actttatgtt gcaggaaacc ctttttgtaa gtctttatta tttactttgc attttgtttc     3240

actctttcca gataagcaga gttgctcttc accagtgttt ttcttcatgt gcaaagtgac     3300

tatttgttct ataatacttt tatgtgtgtt atatcaaatg tgtcttaagc ttcatgcaaa     3360

ctcagtcatc agttcgtgtt gtctgaagca agtgggagat atataaatac ccagtagcta     3420

aaatggtcag tcttttttag atgttttcct acttagtatc tcctaataac gttttgctgt     3480

gtcactagat gttcatttca caagtgcatg tctttctaat aatccacaca tttcatgctc     3540

taataatcca cacatttcat gctcattttt attgttttta cagccagtta tagtaagaaa     3600

aaggtttttc cccttgtgct gctttataat ttagcgtgtg tctgaacctt atccatgttt     3660

gctagatgag gtcttgtcaa atatatcact accattgtca ccggtgaaaa gaaacaggta     3720

gttaagttag ggttaacatt catttcaacc acgaggttgt atatcatgac tagcttttac     3780

tcttggttta cagagaaaag ttaaacagcc aactaggcag tttttaagaa tattaacaat     3840

atattaacaa acaccaatac aactaatcct atttggtttt aatgatttca ccatgggatt     3900

aagaactata tcaggaacat ccctgagaaa cggttttaag tgtagcaact actcttcctt     3960

aatggacagc cacataacgt gtaggaagtc ctttatcact tatcctcgat ccataagcat     4020

atcttgcaga ggggaactac ttctttaaac acatggaggg aaagaagatg atgccactgg     4080

caccagaggg ttagtactgt gatgcatcct aaaatattta ttatattggt aaaaattctg     4140

gttaaataaa aaattagaga tcactcttgg ctgatttcag caccaggaac tgtattacag     4200

ttttagagat taattcctag tgtttacctg attatagcag ttggcatcat ggggcattta     4260

attctgactt tatccccacg tcagccttaa taaagtcttc tttaccttct ctatgaagac     4320

tttaaagccc aaataatcat ttttcacatt gatattcaag aattgagata gatagaagcc     4380

aaagtgggta tctgacaagt ggaaaatcaa acgtttaaga agaattacaa ctctgaaaag     4440

catttatatg tggaacttct caaggagcct cctggggact ggaaagtaag tcatcagcca     4500

ggcaaatgac tcatgctgaa gagagtcccc atttcagtcc cctgagatct agctgatgct     4560

tagatccttt gaaataaaaa ttatgtcttt ataactctga tcttttacat aaagcagaag     4620

aggaatcaac tagttaattg caaggtttct actctgtttc ctctgtaaag atcagatggt     4680

aatctttcaa ataagaaaaa aataaagacg tatgtttgac caagtagttt cacaagaata     4740

tttgggaact tgtttctttt aattttattt gtccctgagt gaagtctaga aagaaaggta     4800

aagagtctag agtttattcc tctttccaaa acattctcat tcctctcctc cctacactta     4860

gtatttcccc cacagagtgc ctagaatctt aataatgaat aaaataaaaa gcagcaatat     4920

gtcattaaca aatccagacc tgaaagggta aagggtttat aactgcacta ataaagagag     4980

gctctttttt tttcttccag tttgttggtt tttaatggta ccgtgttgta aagataccca     5040

ctaatggaca atcaaattgc agaaaaggct caatatccaa gagacaggga ctaatgcact     5100

gtacaatctg cttatccttg cccttctctc ttgccaaagt gtgcttcaga aatatatact     5160

gctttaaaaa agaataaaag aatatccttt tacaagtggc tttacatttc ctaaaatgcc     5220

ataagaaaat gcaatatctg ggtactgtat ggggaaaaaa atgtccaagt ttgtgtaaaa     5280

ccagtgcatt tcagcttgca agttactgaa cacaataatg ctgttttaat tttgttttat     5340

atcagttaaa attcacaata atgtagatag aacaaattac agacaaggaa agaaaaaact     5400

tgaatgaaat ggattttaca gaaagcttta tgataatttt tgaatgcatt atttattttt     5460

tgtgccatgc attttttttc tcaccaaatg accttacctg taatacagtc ttgtttgtct     5520

gtttacaacc atgtatttat tgcaatgtac atactgtaat gttaattgta aattatctgt     5580

tcttattaaa acatcatccc atgatgggat ggtgttgata tatttggaaa ctcttggtga     5640

gagaatgaat ggtgtgtata catactctgt acatttttct tttctcctgt aatatagtct     5700

tgtcacctta gagcttgttt atggaagatt caagaaaact ataaaatact taaagatata     5760

taaatttaaa aaaacatagc tgcaggtctt tggtcccagg gctgtgcctt aactttaacc     5820

aatattttct tctgttttgc tgcatttgaa aggtaacagt ggagctaggg ctgggcattt     5880

tacatccagg cttttaattg attagaattc tgccaatagg tggattttac aaaaccacag     5940

acaacctctg aaagattctg agaccctttt gagacagaag ctcttaagta cttcttgcca     6000

gggagcagca ctgcatgtgt gatggttgtt tgccatctgt tgatcaggaa ctacttcagc     6060

tacttgcatt tgattatttc cttttttttt ttttttaact cggaaacaca actggggaaa     6120

tatattcttt cccagtgatt ataaacaatc tttttctttt ttttaagtcc ttttggcttc     6180

tagagctcat aggaaaatgg acttgatttg aaattggagc cagagtttac tcgtgttggt     6240

tatctattca tcagcttcct gacatgttaa gagaatacat taaagagaaa atactgtttt     6300

ttaatcctaa aatttttctt ccactaagat aaaccaaatg tccttacata tatgtaaacc     6360

catctattta aacgcaaagg tgggttgatg tcagtttaca tagcagaaag cattcactat     6420

cctctaagat ttgtttctgc aaaactttca ttgctttaga attttaaaat ttcaccttgt     6480

acaatggcca gcccctaaag caggaaacat ttataatgga ttatatggaa acatcctccc     6540

agtacttgcc cagcccttga atcatgtggc ttttcagtga aaggaaagat tctttttcta     6600

ggaaaaatga gcctatttta ttttatttta ttttattttt tgacacaaac tgtagatttt     6660

agcagccctg gcccaaagga atttgattac ttttgtttta aacagtacaa aggggacact     6720

ataattacaa aaacatcctt aactgatttg agttgttttt atttctttgg atatattttc     6780

agagtggtaa attgtgtgtg agaattacaa atgattattc ttttagtggt ttcttagcct     6840

ctcttacagc ccacggggat agtactgtac atcaatacct tcatatgaaa tttttatatg     6900

caatgaaaat aaaagcatgg gttgattctg cctatttatg actcaatctt ttacaaataa     6960

aagattattc attttaaatt atagttcaat cagcatgtct cttaggatac tgaacgtggt     7020

tgaaatgaaa ggatagtgac atcataagtt agtactgata ttcataacca aataaagcca     7080

acttgagtaa ttttgctaca ttaaaaatta ccaaaattac ttagatggcc tataagatta     7140

agcatggtgt tttctaagca agctttgaaa ggggccttcc atacttactt aattgaatat     7200

tctgggatat tgaaaattat tcagatactt gacaattatt tttggttacc tactccgcaa     7260

actacaaagt tttaaggact caacaataag ttaatgagac acagtgtttg ctttcatgga     7320

gcttacagtc tggaggggac aaaggcttaa acaatactca tataattata tatgtgatca     7380

gtacaatgaa ggagctcagt ggggtaaata agcaggaacc tgaacttgat ctgttccgga     7440

gggccacaga aggcttcctt gaggccttga gaaagtgatt tgcatctgag ttctgaagga     7500

ttgtaagagg taactaggga aaaagttgac aggaagagga aggggatcca gacaagaaac     7560

atttgcaaag atcttgaggc ataaatgagc ttgagacatc tggagaaact gaggaaaagt     7620

gagagagtag gcagggcctg gagccgcaga gccattgcta accatcctgt gtgagatatc     7680

ccccattctg tagctttatt ctcataaccc tgctcaattt tctttataac acttctcaca     7740

gatttatata cgtgtttgtt tttgttatct gtctctccca ccagaccaca gctccatgag     7800

agcaaggtct ttgcttacca atatatcact agcacttaaa actatgcctg gtacacagta     7860

ggttcttaat atgtgttgaa tatagccatc aaattgatat tggatataat tcaatctgat     7920

aagatatttt gagatattaa agagttttta acttgatacc ataaaaaaaa aaaaaaaaa      7979


<210>  2
<211>  745
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Gln Thr Ser Pro Asp Thr Leu Thr Val Pro Glu Val Asp 
1               5                   10                  15      


Asn Pro His Cys Pro Asn Pro Trp Leu Asn Glu Asp Leu Val Lys Ser 
            20                  25                  30          


Leu Arg Glu Asn Leu Leu Gln His Glu Lys Ser Lys Thr Ala Arg Lys 
        35                  40                  45              


Ser Val Ser Pro Lys Leu Ser Pro Val Ile Ser Pro Arg Asn Ser Pro 
    50                  55                  60                  


Arg Leu Leu Arg Arg Met Leu Leu Ser Ser Asn Ile Pro Lys Gln Arg 
65                  70                  75                  80  


Arg Phe Thr Val Ala His Thr Cys Phe Asp Val Asp Asn Gly Thr Ser 
                85                  90                  95      


Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly Ser Gly Leu 
            100                 105                 110         


Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu Ser Phe Leu 
        115                 120                 125             


Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser Met Ser Arg 
    130                 135                 140                 


Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu Ile Val Thr 
145                 150                 155                 160 


Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg Asn Asn Phe 
                165                 170                 175     


Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys Arg Ser Pro 
            180                 185                 190         


Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr Glu Glu Ala 
        195                 200                 205             


Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp Trp Cys Leu 
    210                 215                 220                 


Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser Glu Met Ala 
225                 230                 235                 240 


Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr His Leu Ser 
                245                 250                 255     


Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile Ser Asn Thr 
            260                 265                 270         


Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro Thr Gln Lys 
        275                 280                 285             


Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser Gly Val Lys 
    290                 295                 300                 


Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile Pro Arg Phe 
305                 310                 315                 320 


Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu Leu Glu Asp 
                325                 330                 335     


Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu Leu Ser Gly 
            340                 345                 350         


Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln Glu Arg Asp 
        355                 360                 365             


Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile Thr Tyr Leu 
    370                 375                 380                 


Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr His Asn Asn 
385                 390                 395                 400 


Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu Leu Ser Thr 
                405                 410                 415     


Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu Ala Ala Ile 
            420                 425                 430         


Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val Ser Asn Gln 
        435                 440                 445             


Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr Asn Asp Ser 
    450                 455                 460                 


Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys Leu Leu Gln 
465                 470                 475                 480 


Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys Gln Arg Gln 
                485                 490                 495     


Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr Asp Met Ser 
            500                 505                 510         


Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val Glu Thr Lys 
        515                 520                 525             


Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr Ser Asp Arg 
    530                 535                 540                 


Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu Ser Asn Pro 
545                 550                 555                 560 


Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg Ile Met Glu 
                565                 570                 575     


Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly Met Glu Ile 
            580                 585                 590         


Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys Ser Gln Val 
        595                 600                 605             


Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr Trp Ala Asp 
    610                 615                 620                 


Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu Glu Asp Asn 
625                 630                 635                 640 


Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser Pro Ala Pro 
                645                 650                 655     


Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys Phe Gln Phe 
            660                 665                 670         


Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu Lys Asp Ser 
        675                 680                 685             


Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser Lys Thr Leu 
    690                 695                 700                 


Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp Glu Gln Val 
705                 710                 715                 720 


Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro Glu Ala Cys 
                725                 730                 735     


Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745 


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D5_forward primer

<400>  3
gcttctcagc agcaacatc                                                    19


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D5_reverse primer

<400>  4
tgccattgtc cacatcaaaa                                                   20


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D5 probe

<400>  5
acagcggcgt ttcacggtgg caca                                              24


<210>  6
<211>  8130
<212>  DNA
<213>  Homo sapiens

<400>  6
agattatagc ccagcgtacg agaagcacga gtcctatagt tggcgtaccc tgaggcctgc       60

cagttcctgc cttaatgcat atgtagtcgt aattgagttc tgacacggcc ttggatgttt      120

ctgtcctaaa tagctgacat tgcatcttca agactgtcat tccagttggc ttttgagtgg      180

atacgtgcag tgagatcatt gacactggaa acactagttc ccattttaat tacttaaaac      240

accacgatga aaagaaatac ctgtgatttg ctttctcgga gcaaaagtgc ctctgaggaa      300

acactacatt ccagtaatga agaggaagac cctttccgcg gaatggaacc ctatcttgtc      360

cggagacttt catgtcgcaa tattcagctt ccccctctcg ccttcagaca gttggaacaa      420

gctgacttga aaagtgaatc agagaacatt caacgaccaa ccagcctccc cctgaagatt      480

ctgccgctga ttgctatcac ttctgcagaa tccagtggtt ttgatgtgga caatggcaca      540

tctgcgggac ggagtccctt ggatcccatg accagcccag gatccgggct aattctccaa      600

gcaaattttg tccacagtca acgacgggag tccttcctgt atcgatccga cagcgattat      660

gacctctctc caaagtctat gtcccggaac tcctccattg ccagtgatat acacggagat      720

gacttgattg tgactccatt tgctcaggtc ttggccagtc tgcgaactgt acgaaacaac      780

tttgctgcat taactaattt gcaagatcga gcacctagca aaagatcacc catgtgcaac      840

caaccatcca tcaacaaagc caccataaca gaggaggcct accagaaact ggccagcgag      900

accctggagg agctggactg gtgtctggac cagctagaga ccctacagac caggcactcc      960

gtcagtgaga tggcctccaa caagtttaaa aggatgctta atcgggagct cacccatctc     1020

tctgaaatga gtcggtctgg aaatcaagtg tcagagttta tatcaaacac attcttagat     1080

aagcaacatg aagtggaaat tccttctcca actcagaagg aaaaggagaa aaagaaaaga     1140

ccaatgtctc agatcagtgg agtcaagaaa ttgatgcaca gctctagtct gactaattca     1200

agtatcccaa ggtttggagt taaaactgaa caagaagatg tccttgccaa ggaactagaa     1260

gatgtgaaca aatggggtct tcatgttttc agaatagcag agttgtctgg taaccggccc     1320

ttgactgtta tcatgcacac catttttcag gaacgggatt tattaaaaac atttaaaatt     1380

ccagtagata ctttaattac atatcttatg actctcgaag accattacca tgctgatgtg     1440

gcctatcaca acaatatcca tgctgcagat gttgtccagt ctactcatgt gctattatct     1500

acacctgctt tggaggctgt gtttacagat ttggagattc ttgcagcaat ttttgccagt     1560

gcaatacatg atgtagatca tcctggtgtg tccaatcaat ttctgatcaa tacaaactct     1620

gaacttgcct tgatgtacaa tgattcctca gtcttagaga accatcattt ggctgtgggc     1680

tttaaattgc ttcaggaaga aaactgtgac attttccaga atttgaccaa aaaacaaaga     1740

caatctttaa ggaaaatggt cattgacatc gtacttgcaa cagatatgtc aaaacacatg     1800

aatctactgg ctgatttgaa gactatggtt gaaactaaga aagtgacaag ctctggagtt     1860

cttcttcttg ataattattc cgataggatt caggttcttc agaatatggt gcactgtgca     1920

gatctgagca acccaacaaa gcctctccag ctgtaccgcc agtggacgga ccggataatg     1980

gaggagttct tccgccaagg agaccgagag agggaacgtg gcatggagat aagccccatg     2040

tgtgacaagc acaatgcttc cgtggaaaaa tcacaggtgg gcttcataga ctatattgtt     2100

catcccctct gggagacatg ggcagacctc gtccaccctg acgcccagga tattttggac     2160

actttggagg acaatcgtga atggtaccag agcacaatcc ctcagagccc ctctcctgca     2220

cctgatgacc cagaggaggg ccggcagggt caaactgaga aattccagtt tgaactaact     2280

ttagaggaag atggtgagtc agacacggaa aaggacagtg gcagtcaagt ggaagaagac     2340

actagctgca gtgactccaa gactctttgt actcaagact cagagtctac tgaaattccc     2400

cttgatgaac aggttgaaga ggaggcagta ggggaagaag aggaaagcca gcctgaagcc     2460

tgtgtcatag atgatcgttc tcctgacacg taacagtgca aaaactttca tgcctttttt     2520

ttttttaagt agaaaaattg tttccaaagt gcatgtcaca tgccacaacc acggtcacac     2580

ctcactgtca tctgccagga cgtttgttga acaaaactga ccttgactac tcagtccagc     2640

gctcaggaat atcgtaacca gttttttcac ctccatgtca tccgagcaag gtggacatct     2700

tcacgaacag cgtttttaac aagatttcag cttggtagag ctgacaaagc agataaaatc     2760

tactccaaat tattttcaag agagtgtgac tcatcaggca gcccaaaagt ttattggact     2820

tggggtttct attccttttt atttgtttgc aatattttca gaagaaaggc attgcacaga     2880

gtgaacttaa tggacgaagc aacaaatatg tcaagaacag gacatagcac gaatctgtta     2940

ccagtaggag gaggatgagc cacagaaatt gcataatttt ctaatttcaa gtcttcctga     3000

tacatgactg aatagtgtgg ttcagtgagc tgcactgacc tctacatttt gtatgatatg     3060

taaaacagat tttttgtaga gcttactttt attattaaat gtattgaggt attatattta     3120

aaaaaaacta tgttcagaac ttcatctgcc actggttatt tttttctaag gagtaacttg     3180

caagttttca gtacaaatct gtgctacact ggataaaaat ctaatttatg aattttactt     3240

gcaccttata gttcatagca attaactgat ttgtagtgat tcattgtttg ttttatatac     3300

caatgacttc catattttaa aagagaaaaa caactttatg ttgcaggaaa ccctttttgt     3360

aagtctttat tatttacttt gcattttgtt tcactctttc cagataagca gagttgctct     3420

tcaccagtgt ttttcttcat gtgcaaagtg actatttgtt ctataatact tttatgtgtg     3480

ttatatcaaa tgtgtcttaa gcttcatgca aactcagtca tcagttcgtg ttgtctgaag     3540

caagtgggag atatataaat acccagtagc taaaatggtc agtctttttt agatgttttc     3600

ctacttagta tctcctaata acgttttgct gtgtcactag atgttcattt cacaagtgca     3660

tgtctttcta ataatccaca catttcatgc tctaataatc cacacatttc atgctcattt     3720

ttattgtttt tacagccagt tatagtaaga aaaaggtttt tccccttgtg ctgctttata     3780

atttagcgtg tgtctgaacc ttatccatgt ttgctagatg aggtcttgtc aaatatatca     3840

ctaccattgt caccggtgaa aagaaacagg tagttaagtt agggttaaca ttcatttcaa     3900

ccacgaggtt gtatatcatg actagctttt actcttggtt tacagagaaa agttaaacag     3960

ccaactaggc agtttttaag aatattaaca atatattaac aaacaccaat acaactaatc     4020

ctatttggtt ttaatgattt caccatggga ttaagaacta tatcaggaac atccctgaga     4080

aacggtttta agtgtagcaa ctactcttcc ttaatggaca gccacataac gtgtaggaag     4140

tcctttatca cttatcctcg atccataagc atatcttgca gaggggaact acttctttaa     4200

acacatggag ggaaagaaga tgatgccact ggcaccagag ggttagtact gtgatgcatc     4260

ctaaaatatt tattatattg gtaaaaattc tggttaaata aaaaattaga gatcactctt     4320

ggctgatttc agcaccagga actgtattac agttttagag attaattcct agtgtttacc     4380

tgattatagc agttggcatc atggggcatt taattctgac tttatcccca cgtcagcctt     4440

aataaagtct tctttacctt ctctatgaag actttaaagc ccaaataatc atttttcaca     4500

ttgatattca agaattgaga tagatagaag ccaaagtggg tatctgacaa gtggaaaatc     4560

aaacgtttaa gaagaattac aactctgaaa agcatttata tgtggaactt ctcaaggagc     4620

ctcctgggga ctggaaagta agtcatcagc caggcaaatg actcatgctg aagagagtcc     4680

ccatttcagt cccctgagat ctagctgatg cttagatcct ttgaaataaa aattatgtct     4740

ttataactct gatcttttac ataaagcaga agaggaatca actagttaat tgcaaggttt     4800

ctactctgtt tcctctgtaa agatcagatg gtaatctttc aaataagaaa aaaataaaga     4860

cgtatgtttg accaagtagt ttcacaagaa tatttgggaa cttgtttctt ttaattttat     4920

ttgtccctga gtgaagtcta gaaagaaagg taaagagtct agagtttatt cctctttcca     4980

aaacattctc attcctctcc tccctacact tagtatttcc cccacagagt gcctagaatc     5040

ttaataatga ataaaataaa aagcagcaat atgtcattaa caaatccaga cctgaaaggg     5100

taaagggttt ataactgcac taataaagag aggctctttt tttttcttcc agtttgttgg     5160

tttttaatgg taccgtgttg taaagatacc cactaatgga caatcaaatt gcagaaaagg     5220

ctcaatatcc aagagacagg gactaatgca ctgtacaatc tgcttatcct tgcccttctc     5280

tcttgccaaa gtgtgcttca gaaatatata ctgctttaaa aaagaataaa agaatatcct     5340

tttacaagtg gctttacatt tcctaaaatg ccataagaaa atgcaatatc tgggtactgt     5400

atggggaaaa aaatgtccaa gtttgtgtaa aaccagtgca tttcagcttg caagttactg     5460

aacacaataa tgctgtttta attttgtttt atatcagtta aaattcacaa taatgtagat     5520

agaacaaatt acagacaagg aaagaaaaaa cttgaatgaa atggatttta cagaaagctt     5580

tatgataatt tttgaatgca ttatttattt tttgtgccat gcattttttt tctcaccaaa     5640

tgaccttacc tgtaatacag tcttgtttgt ctgtttacaa ccatgtattt attgcaatgt     5700

acatactgta atgttaattg taaattatct gttcttatta aaacatcatc ccatgatggg     5760

atggtgttga tatatttgga aactcttggt gagagaatga atggtgtgta tacatactct     5820

gtacattttt cttttctcct gtaatatagt cttgtcacct tagagcttgt ttatggaaga     5880

ttcaagaaaa ctataaaata cttaaagata tataaattta aaaaaacata gctgcaggtc     5940

tttggtccca gggctgtgcc ttaactttaa ccaatatttt cttctgtttt gctgcatttg     6000

aaaggtaaca gtggagctag ggctgggcat tttacatcca ggcttttaat tgattagaat     6060

tctgccaata ggtggatttt acaaaaccac agacaacctc tgaaagattc tgagaccctt     6120

ttgagacaga agctcttaag tacttcttgc cagggagcag cactgcatgt gtgatggttg     6180

tttgccatct gttgatcagg aactacttca gctacttgca tttgattatt tccttttttt     6240

ttttttttaa ctcggaaaca caactgggga aatatattct ttcccagtga ttataaacaa     6300

tctttttctt ttttttaagt ccttttggct tctagagctc ataggaaaat ggacttgatt     6360

tgaaattgga gccagagttt actcgtgttg gttatctatt catcagcttc ctgacatgtt     6420

aagagaatac attaaagaga aaatactgtt ttttaatcct aaaatttttc ttccactaag     6480

ataaaccaaa tgtccttaca tatatgtaaa cccatctatt taaacgcaaa ggtgggttga     6540

tgtcagttta catagcagaa agcattcact atcctctaag atttgtttct gcaaaacttt     6600

cattgcttta gaattttaaa atttcacctt gtacaatggc cagcccctaa agcaggaaac     6660

atttataatg gattatatgg aaacatcctc ccagtacttg cccagccctt gaatcatgtg     6720

gcttttcagt gaaaggaaag attctttttc taggaaaaat gagcctattt tattttattt     6780

tattttattt tttgacacaa actgtagatt ttagcagccc tggcccaaag gaatttgatt     6840

acttttgttt taaacagtac aaaggggaca ctataattac aaaaacatcc ttaactgatt     6900

tgagttgttt ttatttcttt ggatatattt tcagagtggt aaattgtgtg tgagaattac     6960

aaatgattat tcttttagtg gtttcttagc ctctcttaca gcccacgggg atagtactgt     7020

acatcaatac cttcatatga aatttttata tgcaatgaaa ataaaagcat gggttgattc     7080

tgcctattta tgactcaatc ttttacaaat aaaagattat tcattttaaa ttatagttca     7140

atcagcatgt ctcttaggat actgaacgtg gttgaaatga aaggatagtg acatcataag     7200

ttagtactga tattcataac caaataaagc caacttgagt aattttgcta cattaaaaat     7260

taccaaaatt acttagatgg cctataagat taagcatggt gttttctaag caagctttga     7320

aaggggcctt ccatacttac ttaattgaat attctgggat attgaaaatt attcagatac     7380

ttgacaatta tttttggtta cctactccgc aaactacaaa gttttaagga ctcaacaata     7440

agttaatgag acacagtgtt tgctttcatg gagcttacag tctggagggg acaaaggctt     7500

aaacaatact catataatta tatatgtgat cagtacaatg aaggagctca gtggggtaaa     7560

taagcaggaa cctgaacttg atctgttccg gagggccaca gaaggcttcc ttgaggcctt     7620

gagaaagtga tttgcatctg agttctgaag gattgtaaga ggtaactagg gaaaaagttg     7680

acaggaagag gaaggggatc cagacaagaa acatttgcaa agatcttgag gcataaatga     7740

gcttgagaca tctggagaaa ctgaggaaaa gtgagagagt aggcagggcc tggagccgca     7800

gagccattgc taaccatcct gtgtgagata tcccccattc tgtagcttta ttctcataac     7860

cctgctcaat tttctttata acacttctca cagatttata tacgtgtttg tttttgttat     7920

ctgtctctcc caccagacca cagctccatg agagcaaggt ctttgcttac caatatatca     7980

ctagcactta aaactatgcc tggtacacag taggttctta atatgtgttg aatatagcca     8040

tcaaattgat attggatata attcaatctg ataagatatt ttgagatatt aaagagtttt     8100

taacttgata ccataaaaaa aaaaaaaaaa                                      8130


<210>  7
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Lys Arg Asn Thr Cys Asp Leu Leu Ser Arg Ser Lys Ser Ala Ser 
1               5                   10                  15      


Glu Glu Thr Leu His Ser Ser Asn Glu Glu Glu Asp Pro Phe Arg Gly 
            20                  25                  30          


Met Glu Pro Tyr Leu Val Arg Arg Leu Ser Cys Arg Asn Ile Gln Leu 
        35                  40                  45              


Pro Pro Leu Ala Phe Arg Gln Leu Glu Gln Ala Asp Leu Lys Ser Glu 
    50                  55                  60                  


Ser Glu Asn Ile Gln Arg Pro Thr Ser Leu Pro Leu Lys Ile Leu Pro 
65                  70                  75                  80  


Leu Ile Ala Ile Thr Ser Ala Glu Ser Ser Gly Phe Asp Val Asp Asn 
                85                  90                  95      


Gly Thr Ser Ala Gly Arg Ser Pro Leu Asp Pro Met Thr Ser Pro Gly 
            100                 105                 110         


Ser Gly Leu Ile Leu Gln Ala Asn Phe Val His Ser Gln Arg Arg Glu 
        115                 120                 125             


Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr Asp Leu Ser Pro Lys Ser 
    130                 135                 140                 


Met Ser Arg Asn Ser Ser Ile Ala Ser Asp Ile His Gly Asp Asp Leu 
145                 150                 155                 160 


Ile Val Thr Pro Phe Ala Gln Val Leu Ala Ser Leu Arg Thr Val Arg 
                165                 170                 175     


Asn Asn Phe Ala Ala Leu Thr Asn Leu Gln Asp Arg Ala Pro Ser Lys 
            180                 185                 190         


Arg Ser Pro Met Cys Asn Gln Pro Ser Ile Asn Lys Ala Thr Ile Thr 
        195                 200                 205             


Glu Glu Ala Tyr Gln Lys Leu Ala Ser Glu Thr Leu Glu Glu Leu Asp 
    210                 215                 220                 


Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln Thr Arg His Ser Val Ser 
225                 230                 235                 240 


Glu Met Ala Ser Asn Lys Phe Lys Arg Met Leu Asn Arg Glu Leu Thr 
                245                 250                 255     


His Leu Ser Glu Met Ser Arg Ser Gly Asn Gln Val Ser Glu Phe Ile 
            260                 265                 270         


Ser Asn Thr Phe Leu Asp Lys Gln His Glu Val Glu Ile Pro Ser Pro 
        275                 280                 285             


Thr Gln Lys Glu Lys Glu Lys Lys Lys Arg Pro Met Ser Gln Ile Ser 
    290                 295                 300                 


Gly Val Lys Lys Leu Met His Ser Ser Ser Leu Thr Asn Ser Ser Ile 
305                 310                 315                 320 


Pro Arg Phe Gly Val Lys Thr Glu Gln Glu Asp Val Leu Ala Lys Glu 
                325                 330                 335     


Leu Glu Asp Val Asn Lys Trp Gly Leu His Val Phe Arg Ile Ala Glu 
            340                 345                 350         


Leu Ser Gly Asn Arg Pro Leu Thr Val Ile Met His Thr Ile Phe Gln 
        355                 360                 365             


Glu Arg Asp Leu Leu Lys Thr Phe Lys Ile Pro Val Asp Thr Leu Ile 
    370                 375                 380                 


Thr Tyr Leu Met Thr Leu Glu Asp His Tyr His Ala Asp Val Ala Tyr 
385                 390                 395                 400 


His Asn Asn Ile His Ala Ala Asp Val Val Gln Ser Thr His Val Leu 
                405                 410                 415     


Leu Ser Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu Glu Ile Leu 
            420                 425                 430         


Ala Ala Ile Phe Ala Ser Ala Ile His Asp Val Asp His Pro Gly Val 
        435                 440                 445             


Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala Leu Met Tyr 
    450                 455                 460                 


Asn Asp Ser Ser Val Leu Glu Asn His His Leu Ala Val Gly Phe Lys 
465                 470                 475                 480 


Leu Leu Gln Glu Glu Asn Cys Asp Ile Phe Gln Asn Leu Thr Lys Lys 
                485                 490                 495     


Gln Arg Gln Ser Leu Arg Lys Met Val Ile Asp Ile Val Leu Ala Thr 
            500                 505                 510         


Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys Thr Met Val 
        515                 520                 525             


Glu Thr Lys Lys Val Thr Ser Ser Gly Val Leu Leu Leu Asp Asn Tyr 
    530                 535                 540                 


Ser Asp Arg Ile Gln Val Leu Gln Asn Met Val His Cys Ala Asp Leu 
545                 550                 555                 560 


Ser Asn Pro Thr Lys Pro Leu Gln Leu Tyr Arg Gln Trp Thr Asp Arg 
                565                 570                 575     


Ile Met Glu Glu Phe Phe Arg Gln Gly Asp Arg Glu Arg Glu Arg Gly 
            580                 585                 590         


Met Glu Ile Ser Pro Met Cys Asp Lys His Asn Ala Ser Val Glu Lys 
        595                 600                 605             


Ser Gln Val Gly Phe Ile Asp Tyr Ile Val His Pro Leu Trp Glu Thr 
    610                 615                 620                 


Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Ile Leu Asp Thr Leu 
625                 630                 635                 640 


Glu Asp Asn Arg Glu Trp Tyr Gln Ser Thr Ile Pro Gln Ser Pro Ser 
                645                 650                 655     


Pro Ala Pro Asp Asp Pro Glu Glu Gly Arg Gln Gly Gln Thr Glu Lys 
            660                 665                 670         


Phe Gln Phe Glu Leu Thr Leu Glu Glu Asp Gly Glu Ser Asp Thr Glu 
        675                 680                 685             


Lys Asp Ser Gly Ser Gln Val Glu Glu Asp Thr Ser Cys Ser Asp Ser 
    690                 695                 700                 


Lys Thr Leu Cys Thr Gln Asp Ser Glu Ser Thr Glu Ile Pro Leu Asp 
705                 710                 715                 720 


Glu Gln Val Glu Glu Glu Ala Val Gly Glu Glu Glu Glu Ser Gln Pro 
                725                 730                 735     


Glu Ala Cys Val Ile Asp Asp Arg Ser Pro Asp Thr 
            740                 745             


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7

<400>  8
gaacattcaa cgaccaacca                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7_reverse primer

<400>  9
tgccattgtc cacatcaaaa                                                   20


<210>  10
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PDE4D7 probe

<400>  10
ctgccgctga ttgctatcac ttctgca                                           27


<210>  11
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  11
ccattggcct gtagattcac ctcccctggg cagggcccca ggacccagga taatatctgt       60

gcctcctgcc cagaaccctc caagcagaca caatggtaag aatggtgcct gtcctgctgt      120

ctctgctgct gcttctgggt cctgctgtcc cccaggagaa ccaagatggt cgttactctc      180

tgacctatat ctacactggg ctgtccaagc atgttgaaga cgtccccgcg tttcaggccc      240

ttggctcact caatgacctc cagttcttta gatacaacag taaagacagg aagtctcagc      300

ccatgggact ctggagacag gtggaaggaa tggaggattg gaagcaggac agccaacttc      360

agaaggccag ggaggacatc tttatggaga ccctgaaaga catcgtggag tattacaacg      420

acagtaacgg gtctcacgta ttgcagggaa ggtttggttg tgagatcgag aataacagaa      480

gcagcggagc attctggaaa tattactatg atggaaagga ctacattgaa ttcaacaaag      540

aaatcccagc ctgggtcccc ttcgacccag cagcccagat aaccaagcag aagtgggagg      600

cagaaccagt ctacgtgcag cgggccaagg cttacctgga ggaggagtgc cctgcgactc      660

tgcggaaata cctgaaatac agcaaaaata tcctggaccg gcaagatcct ccctctgtgg      720

tggtcaccag ccaccaggcc ccaggagaaa agaagaaact gaagtgcctg gcctacgact      780

tctacccagg gaaaattgat gtgcactgga ctcgggccgg cgaggtgcag gagcctgagt      840

tacggggaga tgttcttcac aatggaaatg gcacttacca gtcctgggtg gtggtggcag      900

tgcccccgca ggacacagcc ccctactcct gccacgtgca gcacagcagc ctggcccagc      960

ccctcgtggt gccctgggag gccagctagg aagcaagggt tggaggcaat gtgggatctc     1020

agacccagta gctgcccttc ctgcctgatg tgggagctga accacagaaa tcacagtcaa     1080

tggatccaca aggcctgagg agcagtgtgg ggggacagac aggaggtgga tttggagacc     1140

gaagactggg atgcctgtct tgagtagact tggacccaaa aaatcatctc accttgagcc     1200

cacccccacc ccattgtcta atctgtagaa gctaataaat aatcatccct ccttgcctag     1260

cataaaaaaa aaaaaaaa                                                   1278


<210>  12
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Val Arg Met Val Pro Val Leu Leu Ser Leu Leu Leu Leu Leu Gly 
1               5                   10                  15      


Pro Ala Val Pro Gln Glu Asn Gln Asp Gly Arg Tyr Ser Leu Thr Tyr 
            20                  25                  30          


Ile Tyr Thr Gly Leu Ser Lys His Val Glu Asp Val Pro Ala Phe Gln 
        35                  40                  45              


Ala Leu Gly Ser Leu Asn Asp Leu Gln Phe Phe Arg Tyr Asn Ser Lys 
    50                  55                  60                  


Asp Arg Lys Ser Gln Pro Met Gly Leu Trp Arg Gln Val Glu Gly Met 
65                  70                  75                  80  


Glu Asp Trp Lys Gln Asp Ser Gln Leu Gln Lys Ala Arg Glu Asp Ile 
                85                  90                  95      


Phe Met Glu Thr Leu Lys Asp Ile Val Glu Tyr Tyr Asn Asp Ser Asn 
            100                 105                 110         


Gly Ser His Val Leu Gln Gly Arg Phe Gly Cys Glu Ile Glu Asn Asn 
        115                 120                 125             


Arg Ser Ser Gly Ala Phe Trp Lys Tyr Tyr Tyr Asp Gly Lys Asp Tyr 
    130                 135                 140                 


Ile Glu Phe Asn Lys Glu Ile Pro Ala Trp Val Pro Phe Asp Pro Ala 
145                 150                 155                 160 


Ala Gln Ile Thr Lys Gln Lys Trp Glu Ala Glu Pro Val Tyr Val Gln 
                165                 170                 175     


Arg Ala Lys Ala Tyr Leu Glu Glu Glu Cys Pro Ala Thr Leu Arg Lys 
            180                 185                 190         


Tyr Leu Lys Tyr Ser Lys Asn Ile Leu Asp Arg Gln Asp Pro Pro Ser 
        195                 200                 205             


Val Val Val Thr Ser His Gln Ala Pro Gly Glu Lys Lys Lys Leu Lys 
    210                 215                 220                 


Cys Leu Ala Tyr Asp Phe Tyr Pro Gly Lys Ile Asp Val His Trp Thr 
225                 230                 235                 240 


Arg Ala Gly Glu Val Gln Glu Pro Glu Leu Arg Gly Asp Val Leu His 
                245                 250                 255     


Asn Gly Asn Gly Thr Tyr Gln Ser Trp Val Val Val Ala Val Pro Pro 
            260                 265                 270         


Gln Asp Thr Ala Pro Tyr Ser Cys His Val Gln His Ser Ser Leu Ala 
        275                 280                 285             


Gln Pro Leu Val Val Pro Trp Glu Ala Ser 
    290                 295             


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZGP1_forward primer

<400>  13
tggagaccct gaaagacatc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZGP1_reverse primer

<400>  14
ctcgatctca caaccaaacc                                                   20


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AZGP1 probe

<400>  15
acgggtctca cgtattgcag gga                                               23


<210>  16
<211>  2312
<212>  DNA
<213>  Homo sapiens

<400>  16
ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct       60

cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg      120

ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg      180

cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc      240

ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg      300

ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc      360

cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt      420

gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat      480

tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg      540

gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga      600

gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa      660

gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga      720

gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt      780

gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa      840

tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc      900

tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat      960

aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag     1020

ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag     1080

tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc     1140

tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga     1200

acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat     1260

cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac     1320

ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt     1380

ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg     1440

ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc     1500

caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc     1560

agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc     1620

cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg     1680

tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact     1740

ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc     1800

ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacccgctg tgagcgcttg     1860

ccttgccatg agaatcggga gtgctccaag ctgcctctga gaataaccta ctaccacctc     1920

tctttcccca ccaacatcca agcgcccgcg gtggttttcc gcatgggccc ctccagtgct     1980

gtccccgggg acagcatgca gctggccatc accggcggca atgaggaggg ctttttcacc     2040

acccggaagg tgagccccca cagtggggtg gtggccctca ccaagcctgt ccccgagccc     2100

agggacttgc tcctgaccgt caagatggat ctctctcgcc acggcaccgt cagctccttt     2160

gtggccaagc ttttcatctt tgtgtctgca gagctctgag cactcgcttc gcgtcgcggg     2220

gtctccctcc tgttgctttc ctaaccctgc cctccggggc gttaataaag tcttagcaag     2280

cgtcccacac agtgaaaaaa aaaaaaaaaa aa                                   2312


<210>  17
<211>  2662
<212>  DNA
<213>  Homo sapiens

<400>  17
ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct       60

cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg      120

ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg      180

cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc      240

ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg      300

ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc      360

cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt      420

gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat      480

tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg      540

gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga      600

gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa      660

gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga      720

gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt      780

gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa      840

tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc      900

tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat      960

aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag     1020

ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag     1080

tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc     1140

tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga     1200

acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat     1260

cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac     1320

ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt     1380

ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg     1440

ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc     1500

caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc     1560

agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc     1620

cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg     1680

tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact     1740

ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc     1800

ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacgcagaa atccaagaag     1860

ggaaggcaga acaccccagc gggatcaagt aaagaggact gcagggttct tccatggaag     1920

caggggttgg aggataccca ccttgatgcc tagtgaggaa gatggacctg gacagacagt     1980

cagctccaca ccttgcgctg agcagctgtg attgtgccac gggagcatga gcccttttcc     2040

ccacggccct tgccactgtc tcctggccct ctctctgatc atgccaggtt tgcaccagcc     2100

tcgagtctcc catgttgtag tacattctcc aagatgcagc ccaggagcct ctctgaagga     2160

ccagtctggt tacgatggtc tgagcttcct tagaaccttc catggttgtc ttttcccagc     2220

agatgaagca tagcctcctt ggaatggcat gggaggcctg gcctgatctg gcctctgccc     2280

accctttgag ctgcacctgc cccaccccag ctcatccatg tgcttgtacc ctggccccac     2340

ggggaggctt gcccttccct gaatctgcct tcttgtggct ttagcatgtg ccatgctgtc     2400

cccctgcaga ctgccattct ccttgcagac ttggctcaga agtcacctcc tcagtgcagt     2460

tagcctgagc tcccctggcc ccaggtgcct ccatcagagc atttacccca ttgtgttgtg     2520

gctgttcctt aacgtcccca ctagccaggc tctttgaggg cagggattgt gtctggttaa     2580

tttctgtatt ctctgcaact ttgcaatgtt tggcttgaag aaggagctca gtaaacatct     2640

gaataaacat gcaggttgat gg                                              2662


<210>  18
<211>  2947
<212>  DNA
<213>  Homo sapiens

<400>  18
ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct       60

cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg      120

ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg      180

cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc      240

ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg      300

ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc      360

cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt      420

gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat      480

tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg      540

gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga      600

gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa      660

gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga      720

gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt      780

gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa      840

tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc      900

tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat      960

aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag     1020

ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag     1080

tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc     1140

tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga     1200

acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat     1260

cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac     1320

ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt     1380

ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg     1440

ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc     1500

caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc     1560

agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc     1620

cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg     1680

tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact     1740

ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc     1800

ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacgctcca gcaggagaag     1860

acagacacgg tccgctgcat caagtcctgc cgccccaacg atgtcacatg cgtgttcgac     1920

cccgtgcaca ccatctccca caccgtcatc tcgctgccta ccttccgcga gttcacccgc     1980

cctgaagaga tcatcttcct ccgggccatc acgccaccgc atcctgccag ccaggctaac     2040

atcatcttcg acatcacgga agggaacctg cgggactctt ttgacatcat caagcgttac     2100

atggacggca tgaccgtggg tgtcgtgcgc caggtgcggc ccatcgtggg cccatttcat     2160

gccgtcctga agctggagat gaactatgtg gtcgggggcg tggtctccca ccgaaatgtt     2220

gtcaacgtcc acatcttcgt ctctgagtac tggttctgag ggctggtctg ccgcacagcc     2280

gcaggtgcac ctccaggcca aatcattgct gccagtgact gtggtctgta cttgtttata     2340

ccctcagact tttttaatgt taggtatttg tagcattagg ccaacatgta ttaagctgag     2400

ccagatgaat aagtccatct gatgtatttt cggtgtttaa aaaatgagcc cagttgctca     2460

actgtttggt tgaaaacctt gctcattttt taatgcgaag gctaagtgtc accccctttc     2520

tctgcctctg gctgggcctt gctaagggcc aaggaaagaa agacattttt tagggggcag     2580

ccagtccaaa tgccaaaaga agaccagttc ttgccctgat tgtatgaaat ttgacatttt     2640

ggcacttttt tttttttttt ggccaatcag attttctatg ttctaaggac atggctgctg     2700

tagaatagca cagacgtgga tgataaatta tccccagaag cagcatgaca gaatgcctcg     2760

gggagcactt ggaagggaaa ttgcagttct gttgaaatag aggaaaatcc cttggtaaag     2820

acacagcctg ttaggctcgt gtgggcctcc agtatgttca ccaggggaat ggctgggatt     2880

tctcggcact ctgcatcatc catcttttct tataggtggg aaaataaaca actttgtgat     2940

cctcctg                                                               2947


<210>  19
<211>  2485
<212>  DNA
<213>  Homo sapiens

<400>  19
ctcctcccgg gcgggataat tgaacggcgc ggccctggcc cagcgttggc tgccgaggct       60

cggccggagc gtggagcccg cgccgctgcc ccaggaccgc gcccgcgcct ttgtccgccg      120

ccgcccaccg cccgtcgccc gccgcccatg gagcgcgccg cgccgtcgcg ccgggtcccg      180

cttccgctgc tgctgctcgg cggccttgcg ctgctggcgg ccggagtgga cgcggatgtc      240

ctcctggagg cctgctgtgc ggacggacac cggatggcca ctcatcagaa ggactgctcg      300

ctgccatatg ctacggaatc caaagaatgc aggatggtgc aggagcagtg ctgccacagc      360

cagctggagg agctgcactg tgccacgggc atcagcctgg ccaacgagca ggaccgctgt      420

gccacgcccc acggtgacaa cgccagcctg gaggccacat ttgtgaagag gtgctgccat      480

tgctgtctgc tggggagggc ggcccaggcc cagggccaga gctgcgagta cagcctcatg      540

gttggctacc agtgtggaca ggtcttccgg gcatgctgtg tcaagagcca ggagaccgga      600

gatttggatg tcgggggcct ccaagaaacg gataagatca ttgaggttga ggaggaacaa      660

gaggacccat atctgaatga ccgctgccga ggaggcgggc cctgcaagca gcagtgccga      720

gacacgggtg acgaggtggt ctgctcctgc ttcgtgggct accagctgct gtctgatggt      780

gtctcctgtg aagatgtcaa tgaatgcatc acgggcagcc acagctgccg gcttggagaa      840

tcctgcatca acacagtggg ctctttccgc tgccagcggg acagcagctg cgggactggc      900

tatgagctca cagaggacaa tagctgcaaa gatattgacg agtgtgagag tggtattcat      960

aactgcctcc ccgattttat ctgtcagaat actctgggat ccttccgctg ccgacccaag     1020

ctacagtgca agagtggctt tatacaagat gctctaggca actgtattga tatcaatgag     1080

tgtttgagta tcagtgcccc gtgccctatc gggcatacat gcatcaacac agagggctcc     1140

tacacgtgcc agaagaacgt gcccaactgt ggccgtggct accatctcaa cgaggaggga     1200

acgcgctgtg ttgatgtgga cgagtgcgcg ccacctgctg agccctgtgg gaagggacat     1260

cgctgcgtga actctcccgg cagtttccgc tgcgaatgca agacgggtta ctattttgac     1320

ggcatcagca ggatgtgtgt cgatgtcaac gagtgccagc gctaccccgg gcgcctgtgt     1380

ggccacaagt gcgagaacac gctgggctcc tacctctgca gctgttccgt gggcttccgg     1440

ctctctgtgg atggcaggtc atgtgaagac atcaatgagt gcagcagcag cccctgtagc     1500

caggagtgtg ccaacgtcta cggctcctac cagtgttact gccggcgagg ctaccagctc     1560

agcgatgtgg atggagtcac ctgtgaagac atcgacgagt gcgccctgcc caccgggggc     1620

cacatctgct cctaccgctg catcaacatc cctggaagct tccagtgcag ctgcccctcg     1680

tctggctaca ggctggcccc caatggccgc aactgccaag acattgatga gtgtgtgact     1740

ggcatccaca actgctccat caacgagacc tgcttcaaca tccagggcgg cttccgctgc     1800

ctggccttcg agtgccctga gaactaccgc cgctccgcag ccacatgatc gtagggaact     1860

ctgcatgagg ccatcggtgc aggctggaga agagaaggca agttggcagg agtggagacc     1920

acgggcattt gagccacttc ctcatgtaac ttaacttgtg ccttcaggac ctgctcaagc     1980

ccgatcacgt atataccact tccatttgat gatggaatgc tgctgttcat gaccaacttt     2040

atggctagat gggtcagaaa gcacccagtt catgataggc agttcaggtc atatggtgac     2100

ttgatgaccc agagtcaaac attcagtttc caccaaagcc cagtaacagg ccaagagctg     2160

tctctcaaaa ggagagtagt tatctgcaga agatggcagg gccttgctcc gaaagcctag     2220

agaccgccac tgtgattcac ctatgggggc ctgccaaagg ctgcagccag catccttatc     2280

tgccactgac acctcaagca acattggatc tgctgggtca tatggcccaa gtggcagagc     2340

aacttgcaca acagcctgga cctgtcatag agctttctcc tgttctggac cccactcaaa     2400

actggcagcc tttcaggtca ctcgataaat gtgctggagt aacactcaaa cgaggaatgt     2460

gttgcctcca aaatccaata ggccc                                           2485


<210>  20
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr 
                565     


<210>  21
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Gln Lys Ser Lys Lys Gly Arg Gln Asn Thr 
                565                 570                 575     


Pro Ala Gly Ser Ser Lys Glu Asp Cys Arg Val Leu Pro Trp Lys Gln 
            580                 585                 590         


Gly Leu Glu Asp Thr His Leu Asp Ala 
        595                 600     


<210>  22
<211>  703
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr Leu Gln Gln Glu Lys Thr Asp Thr Val Arg 
                565                 570                 575     


Cys Ile Lys Ser Cys Arg Pro Asn Asp Val Thr Cys Val Phe Asp Pro 
            580                 585                 590         


Val His Thr Ile Ser His Thr Val Ile Ser Leu Pro Thr Phe Arg Glu 
        595                 600                 605             


Phe Thr Arg Pro Glu Glu Ile Ile Phe Leu Arg Ala Ile Thr Pro Pro 
    610                 615                 620                 


His Pro Ala Ser Gln Ala Asn Ile Ile Phe Asp Ile Thr Glu Gly Asn 
625                 630                 635                 640 


Leu Arg Asp Ser Phe Asp Ile Ile Lys Arg Tyr Met Asp Gly Met Thr 
                645                 650                 655     


Val Gly Val Val Arg Gln Val Arg Pro Ile Val Gly Pro Phe His Ala 
            660                 665                 670         


Val Leu Lys Leu Glu Met Asn Tyr Val Val Gly Gly Val Val Ser His 
        675                 680                 685             


Arg Asn Val Val Asn Val His Ile Phe Val Ser Glu Tyr Trp Phe 
    690                 695                 700             


<210>  23
<211>  566
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala Asp Val Leu 
            20                  25                  30          


Leu Glu Ala Cys Cys Ala Asp Gly His Arg Met Ala Thr His Gln Lys 
        35                  40                  45              


Asp Cys Ser Leu Pro Tyr Ala Thr Glu Ser Lys Glu Cys Arg Met Val 
    50                  55                  60                  


Gln Glu Gln Cys Cys His Ser Gln Leu Glu Glu Leu His Cys Ala Thr 
65                  70                  75                  80  


Gly Ile Ser Leu Ala Asn Glu Gln Asp Arg Cys Ala Thr Pro His Gly 
                85                  90                  95      


Asp Asn Ala Ser Leu Glu Ala Thr Phe Val Lys Arg Cys Cys His Cys 
            100                 105                 110         


Cys Leu Leu Gly Arg Ala Ala Gln Ala Gln Gly Gln Ser Cys Glu Tyr 
        115                 120                 125             


Ser Leu Met Val Gly Tyr Gln Cys Gly Gln Val Phe Arg Ala Cys Cys 
    130                 135                 140                 


Val Lys Ser Gln Glu Thr Gly Asp Leu Asp Val Gly Gly Leu Gln Glu 
145                 150                 155                 160 


Thr Asp Lys Ile Ile Glu Val Glu Glu Glu Gln Glu Asp Pro Tyr Leu 
                165                 170                 175     


Asn Asp Arg Cys Arg Gly Gly Gly Pro Cys Lys Gln Gln Cys Arg Asp 
            180                 185                 190         


Thr Gly Asp Glu Val Val Cys Ser Cys Phe Val Gly Tyr Gln Leu Leu 
        195                 200                 205             


Ser Asp Gly Val Ser Cys Glu Asp Val Asn Glu Cys Ile Thr Gly Ser 
    210                 215                 220                 


His Ser Cys Arg Leu Gly Glu Ser Cys Ile Asn Thr Val Gly Ser Phe 
225                 230                 235                 240 


Arg Cys Gln Arg Asp Ser Ser Cys Gly Thr Gly Tyr Glu Leu Thr Glu 
                245                 250                 255     


Asp Asn Ser Cys Lys Asp Ile Asp Glu Cys Glu Ser Gly Ile His Asn 
            260                 265                 270         


Cys Leu Pro Asp Phe Ile Cys Gln Asn Thr Leu Gly Ser Phe Arg Cys 
        275                 280                 285             


Arg Pro Lys Leu Gln Cys Lys Ser Gly Phe Ile Gln Asp Ala Leu Gly 
    290                 295                 300                 


Asn Cys Ile Asp Ile Asn Glu Cys Leu Ser Ile Ser Ala Pro Cys Pro 
305                 310                 315                 320 


Ile Gly His Thr Cys Ile Asn Thr Glu Gly Ser Tyr Thr Cys Gln Lys 
                325                 330                 335     


Asn Val Pro Asn Cys Gly Arg Gly Tyr His Leu Asn Glu Glu Gly Thr 
            340                 345                 350         


Arg Cys Val Asp Val Asp Glu Cys Ala Pro Pro Ala Glu Pro Cys Gly 
        355                 360                 365             


Lys Gly His Arg Cys Val Asn Ser Pro Gly Ser Phe Arg Cys Glu Cys 
    370                 375                 380                 


Lys Thr Gly Tyr Tyr Phe Asp Gly Ile Ser Arg Met Cys Val Asp Val 
385                 390                 395                 400 


Asn Glu Cys Gln Arg Tyr Pro Gly Arg Leu Cys Gly His Lys Cys Glu 
                405                 410                 415     


Asn Thr Leu Gly Ser Tyr Leu Cys Ser Cys Ser Val Gly Phe Arg Leu 
            420                 425                 430         


Ser Val Asp Gly Arg Ser Cys Glu Asp Ile Asn Glu Cys Ser Ser Ser 
        435                 440                 445             


Pro Cys Ser Gln Glu Cys Ala Asn Val Tyr Gly Ser Tyr Gln Cys Tyr 
    450                 455                 460                 


Cys Arg Arg Gly Tyr Gln Leu Ser Asp Val Asp Gly Val Thr Cys Glu 
465                 470                 475                 480 


Asp Ile Asp Glu Cys Ala Leu Pro Thr Gly Gly His Ile Cys Ser Tyr 
                485                 490                 495     


Arg Cys Ile Asn Ile Pro Gly Ser Phe Gln Cys Ser Cys Pro Ser Ser 
            500                 505                 510         


Gly Tyr Arg Leu Ala Pro Asn Gly Arg Asn Cys Gln Asp Ile Asp Glu 
        515                 520                 525             


Cys Val Thr Gly Ile His Asn Cys Ser Ile Asn Glu Thr Cys Phe Asn 
    530                 535                 540                 


Ile Gln Gly Gly Phe Arg Cys Leu Ala Phe Glu Cys Pro Glu Asn Tyr 
545                 550                 555                 560 


Arg Arg Ser Ala Ala Thr 
                565     


<210>  24
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FBLN1_forward primer

<400>  24
gcctggaggc cacattt                                                      17


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FBLN1_reverse primer

<400>  25
ccaaccatga ggctgtactc                                                   20


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FBLN1 probe

<400>  26
tgctgccatt gctgtctgct g                                                 21


<210>  27
<211>  1797
<212>  DNA
<213>  Homo sapiens

<400>  27
agggacggag gcccgcgctg cccaagagcg ccacgggcgg ggcggggccg gcggcgggct       60

gcgggcgcgg ccggacggga gttccccgga gaaggatcct gcagcccgag tcccgtcctc      120

aggcttcccc aatccagggg actcggcgcc gggacgctgc tatggacgac attttcactc      180

agtgccggga gggcaacgca gtcgccgttc gcctgtggct ggacaacacg gagaacgacc      240

tcaaccaggg ggacgatcat ggcttctccc ccttgcactg ggcctgccga gagggccgct      300

ctgctgtggt tgagatgttg atcatgcggg gggcacggat caatgtaatg aaccgtgggg      360

atgacacccc cctgcatctg gcagccagtc atggacaccg tgatattgta cagaagctat      420

tgcagtacaa ggcagacatc aatgcagtga atgaacacgg gaatgtgccc ctgcactatg      480

cctgtttttg gggccaagat caagtggcag aggacctggt ggcaaatggg gcccttgtca      540

gcatctgtaa caagtatgga gagatgcctg tggacaaagc caaggcaccc ctgagagagc      600

ttctccgaga gcgggcagag aagatgggcc agaatctcaa ccgtattcca tacaaggaca      660

cattctggaa ggggaccacc cgcactcggc cccgaaatgg aaccctgaac aaacactctg      720

gcattgactt caaacagctt aacttcctga cgaagctcaa cgagaatcac tctggagagc      780

tatggaaggg ccgctggcag ggcaatgaca ttgtcgtgaa ggtgctgaag gttcgagact      840

ggagtacaag gaagagcagg gacttcaatg aagagtgtcc ccggctcagg attttctcgc      900

atccaaatgt gctcccagtg ctaggtgcct gccagtctcc acctgctcct catcctactc      960

tcatcacaca ctggatgccg tatggatccc tctacaatgt actacatgaa ggcaccaatt     1020

tcgtcgtgga ccagagccag gctgtgaagt ttgctttgga catggcaagg ggcatggcct     1080

tcctacacac actagagccc ctcatcccac gacatgcact caatagccgt agtgtaatga     1140

ttgatgagga catgactgcc cgaattagca tggctgatgt caagttctct ttccaatgtc     1200

ctggtcgcat gtatgcacct gcctgggtag cccccgaagc tctgcagaag aagcctgaag     1260

acacaaacag acgctcagca gacatgtgga gttttgcagt gcttctgtgg gaactggtga     1320

cacgggaggt accctttgct gacctctcca atatggagat tggaatgaag gtggcattgg     1380

aaggccttcg gcctaccatc ccaccaggta tttcccctca tgtgtgtaag ctcatgaaga     1440

tctgcatgaa tgaagaccct gcaaagcgac ccaaatttga catgattgtg cctatccttg     1500

agaagatgca ggacaagtag gactggaagg tccttgcctg aactccagag gtgtcgggac     1560

atggttgggg gaatgcacct ccccaaagca gcaggcctct ggttgcctcc cccgcctcca     1620

gtcatggtac taccccagcc atggggtcca tccccttccc ccatccctac cactgtggcc     1680

ccaagagggg cgggctcaga gctttgtcac ttgccacatg gtgtctccca acatgggagg     1740

gatcagcccc gcctgtcaca ataaagttta ttatgaaaac aggaaaaaaa aaaaaaa        1797


<210>  28
<211>  2098
<212>  DNA
<213>  Homo sapiens

<400>  28
agcccgagtc ccggtgagtg cgagaggacc cgcgccccct gtcacccctc acttctcctg       60

agtcccaagt aaggaacgga gccaaccctg gggaggaccc ccggtcccct ctcccagagt      120

atacggagcc tgaacctccc cacttccccc aactctgttc gcggataggg tctagttgcc      180

tgctctcgga catccgttca gcagacacta cctcttcgtc accccctgcc caccctgacc      240

cgcctttacc tcgcgtctag aggacacagc cagggatcat cccgcagccc cgaactcctt      300

cacagacccc cactagccgg ggacgcagct caggccccct acccccaaca caaacacttc      360

tctcctgtag aggataaagc ttggggttca tcctccttcc ctggatcact ccacagtcct      420

caggcttccc caatccaggg gactcggcgc cgggacgctg ctatggacga cattttcact      480

cagtgccggg agggcaacgc agtcgccgtt cgcctgtggc tggacaacac ggagaacgac      540

ctcaaccagg gggacgatca tggcttctcc cccttgcact gggcctgccg agagggccgc      600

tctgctgtgg ttgagatgtt gatcatgcgg ggggcacgga tcaatgtaat gaaccgtggg      660

gatgacaccc ccctgcatct ggcagccagt catggacacc gtgatattgt acagaagcta      720

ttgcagtaca aggcagacat caatgcagtg aatgaacacg ggaatgtgcc cctgcactat      780

gcctgttttt ggggccaaga tcaagtggca gaggacctgg tggcaaatgg ggcccttgtc      840

agcatctgta acaagtatgg agagatgcct gtggacaaag ccaaggcacc cctgagagag      900

cttctccgag agcgggcaga gaagatgggc cagaatctca accgtattcc atacaaggac      960

acattctgga aggggaccac ccgcactcgg ccccgaaatg gaaccctgaa caaacactct     1020

ggcattgact tcaaacagct taacttcctg acgaagctca acgagaatca ctctggagag     1080

ctatggaagg gccgctggca gggcaatgac attgtcgtga aggtgctgaa ggttcgagac     1140

tggagtacaa ggaagagcag ggacttcaat gaagagtgtc cccggctcag gattttctcg     1200

catccaaatg tgctcccagt gctaggtgcc tgccagtctc cacctgctcc tcatcctact     1260

ctcatcacac actggatgcc gtatggatcc ctctacaatg tactacatga aggcaccaat     1320

ttcgtcgtgg accagagcca ggctgtgaag tttgctttgg acatggcaag gggcatggcc     1380

ttcctacaca cactagagcc cctcatccca cgacatgcac tcaatagccg tagtgtaatg     1440

attgatgagg acatgactgc ccgaattagc atggctgatg tcaagttctc tttccaatgt     1500

cctggtcgca tgtatgcacc tgcctgggta gcccccgaag ctctgcagaa gaagcctgaa     1560

gacacaaaca gacgctcagc agacatgtgg agttttgcag tgcttctgtg ggaactggtg     1620

acacgggagg taccctttgc tgacctctcc aatatggaga ttggaatgaa ggtggcattg     1680

gaaggccttc ggcctaccat cccaccaggt atttcccctc atgtgtgtaa gctcatgaag     1740

atctgcatga atgaagaccc tgcaaagcga cccaaatttg acatgattgt gcctatcctt     1800

gagaagatgc aggacaagta ggactggaag gtccttgcct gaactccaga ggtgtcggga     1860

catggttggg ggaatgcacc tccccaaagc agcaggcctc tggttgcctc ccccgcctcc     1920

agtcatggta ctaccccagc catggggtcc atccccttcc cccatcccta ccactgtggc     1980

cccaagaggg gcgggctcag agctttgtca cttgccacat ggtgtctccc aacatgggag     2040

ggatcagccc cgcctgtcac aataaagttt attatgaaaa caggaaaaaa aaaaaaaa       2098


<210>  29
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  29
agggacggag gcccgcgctg cccaagagcg ccacgggcgg ggcggggccg gcggcgggct       60

gcgggcgcgg ccggacggga gttccccgga gaaggatcct gcagcccgag tcccgaggat      120

aaagcttggg gttcatcctc cttccctgga tcactccaca gtcctcaggc ttccccaatc      180

caggggactc ggcgccggga cgctgctatg gacgacattt tcactcagtg ccgggagggc      240

aacgcagtcg ccgttcgcct gtggctggac aacacggaga acgacctcaa ccagggggac      300

gatcatggct tctccccctt gcactgggcc tgccgagagg gccgctctgc tgtggttgag      360

atgttgatca tgcggggggc acggatcaat gtaatgaacc gtggggatga cacccccctg      420

catctggcag ccagtcatgg acaccgtgat attgtacaga agctattgca gtacaaggca      480

gacatcaatg cagtgaatga acacgggaat gtgcccctgc actatgcctg tttttggggc      540

caagatcaag tggcagagag cgggcagaga agatgggcca gaatctcaac cgtattccat      600

acaaggacac attctggaag gggaccaccc gcactcggcc ccctatggaa gggccgctgg      660

cagggcaatg acattgtcgt gaaggtgctg aaggttcgag actggagtac aaggaagagc      720

agggacttca atgaagagtg tccccggctc aggattttct cgcatccaaa tgtgctccca      780

gtgctaggtg cctgccagtc tccacctgct cctcatccta ctctcatcac acactggatg      840

ccgtatggat ccctctacaa tgtactacat gaaggcacca atttcgtcgt ggaccagagc      900

caggctgtga agtttgcttt ggacatggca aggggcatgg ccttcctaca cacactagag      960

cccctcatcc cacgacatgc actcaatagc cgtagtgtaa tgattgatga ggacatgact     1020

gcccgaatta gcatggctga tgtcaagttc tctttccaat gtcctggtcg catgtatgca     1080

cctgcctggg tagcccccga agctctgcag aagaagcctg aagacacaaa cagacgctca     1140

gcagacatgt ggagttttgc agtgcttctg tgggaactgg tgacacggga ggtacccttt     1200

gctgacctct ccaatatgga gattggaatg aaggtggcat tggaaggcct tcggcctacc     1260

atcccaccag gtatttcccc tcatgtgtgt aagctcatga agatctgcat gaatgaagac     1320

cctgcaaagc gacccaaatt tgacatgatt gtgcctatcc ttgagaagat gcaggacaag     1380

taggactgga aggtccttgc ctgaactcca gaggtgtcgg gacatggttg ggggaatgca     1440

cctccccaaa gcagcaggcc tctggttgcc tcccccgcct ccagtcatgg tactacccca     1500

gccatggggt ccatcccctt cccccatccc taccactgtg gccccaagag gggcgggctc     1560

agagctttgt cacttgccac atggtgtctc ccaacatggg agggatcagc cccgcctgtc     1620

acaataaagt ttattatgaa aacaggaaaa aaaaaaaaaa                           1660


<210>  30
<211>  1631
<212>  DNA
<213>  Homo sapiens

<400>  30
agggacggag gcccgcgctg cccaagagcg ccacgggcgg ggcggggccg gcggcgggct       60

gcgggcgcgg ccggacggga gttccccgga gaaggatcct gcagcccgag tcccgtcctc      120

aggcttcccc aatccagggg actcggcgcc gggacgctgc tatggacgac attttcactc      180

agtgccggga gggcaacgca gtcgccgttc gcctgtggct ggacaacacg gagaacgacc      240

tcaaccaggg ctattgcagt acaaggcaga catcaatgca gtgaatgaac acgggaatgt      300

gcccctgcac tatgcctgtt tttggggcca agatcaagtg gcagaggacc tggtggcaaa      360

tggggccctt gtcagcatct gtaacaagta tggagagatg cctgtggaca aagccaaggc      420

acccctgaga gagcttctcc gagagcgggc agagaagatg ggccagaatc tcaaccgtat      480

tccatacaag gacacattct ggaaggggac cacccgcact cggccccgaa atggaaccct      540

gaacaaacac tctggcattg acttcaaaca gcttaacttc ctgacgaagc tcaacgagaa      600

tcactctgga gagctatgga agggccgctg gcagggcaat gacattgtcg tgaaggtgct      660

gaaggttcga gactggagta caaggaagag cagggacttc aatgaagagt gtccccggct      720

caggattttc tcgcatccaa atgtgctccc agtgctaggt gcctgccagt ctccacctgc      780

tcctcatcct actctcatca cacactggat gccgtatgga tccctctaca atgtactaca      840

tgaaggcacc aatttcgtcg tggaccagag ccaggctgtg aagtttgctt tggacatggc      900

aaggggcatg gccttcctac acacactaga gcccctcatc ccacgacatg cactcaatag      960

ccgtagtgta atgattgatg aggacatgac tgcccgaatt agcatggctg atgtcaagtt     1020

ctctttccaa tgtcctggtc gcatgtatgc acctgcctgg gtagcccccg aagctctgca     1080

gaagaagcct gaagacacaa acagacgctc agcagacatg tggagttttg cagtgcttct     1140

gtgggaactg gtgacacggg aggtaccctt tgctgacctc tccaatatgg agattggaat     1200

gaaggtggca ttggaaggcc ttcggcctac catcccacca ggtatttccc ctcatgtgtg     1260

taagctcatg aagatctgca tgaatgaaga ccctgcaaag cgacccaaat ttgacatgat     1320

tgtgcctatc cttgagaaga tgcaggacaa gtaggactgg aaggtccttg cctgaactcc     1380

agaggtgtcg ggacatggtt gggggaatgc acctccccaa agcagcaggc ctctggttgc     1440

ctcccccgcc tccagtcatg gtactacccc agccatgggg tccatcccct tcccccatcc     1500

ctaccactgt ggccccaaga ggggcgggct cagagctttg tcacttgcca catggtgtct     1560

cccaacatgg gagggatcag ccccgcctgt cacaataaag tttattatga aaacaggaaa     1620

aaaaaaaaaa a                                                          1631


<210>  31
<211>  1843
<212>  DNA
<213>  Homo sapiens

<400>  31
agggacggag gcccgcgctg cccaagagcg ccacgggcgg ggcggggccg gcggcgggct       60

gcgggcgcgg ccggacggga gttccccgga gaaggatcct gcagcccgag tcccgaggat      120

aaagcttggg gttcatcctc cttccctgga tcactccaca gtcctcaggc ttccccaatc      180

caggggactc ggcgccggga cgctgctatg gacgacattt tcactcagtg ccgggagggc      240

aacgcagtcg ccgttcgcct gtggctggac aacacggaga acgacctcaa ccagggggac      300

gatcatggct tctccccctt gcactgggcc tgccgagagg gccgctctgc tgtggttgag      360

atgttgatca tgcggggggc acggatcaat gtaatgaacc gtggggatga cacccccctg      420

catctggcag ccagtcatgg acaccgtgat attgtacaga agctattgca gtacaaggca      480

gacatcaatg cagtgaatga acacgggaat gtgcccctgc actatgcctg tttttggggc      540

caagatcaag tggcagagga cctggtggca aatggggccc ttgtcagcat ctgtaacaag      600

tatggagaga tgcctgtgga caaagccaag gcacccctga gagagcttct ccgagagcgg      660

gcagagaaga tgggccagaa tctcaaccgt attccataca aggacacatt ctggaagggg      720

accacccgca ctcggccccg aaatggaacc ctgaacaaac actctggcat tgacttcaaa      780

cagcttaact tcctgacgaa gctcaacgag aatcactctg gagagctatg gaagggccgc      840

tggcagggca atgacattgt cgtgaaggtg ctgaaggttc gagactggag tacaaggaag      900

agcagggact tcaatgaaga gtgtccccgg ctcaggattt tctcgcatcc aaatgtgctc      960

ccagtgctag gtgcctgcca gtctccacct gctcctcatc ctactctcat cacacactgg     1020

atgccgtatg gatccctcta caatgtacta catgaaggca ccaatttcgt cgtggaccag     1080

agccaggctg tgaagtttgc tttggacatg gcaaggggca tggccttcct acacacacta     1140

gagcccctca tcccacgaca tgcactcaat agccgtagtg taatgattga tgaggacatg     1200

actgcccgaa ttagcatggc tgatgtcaag ttctctttcc aatgtcctgg tcgcatgtat     1260

gcacctgcct gggtagcccc cgaagctctg cagaagaagc ctgaagacac aaacagacgc     1320

tcagcagaca tgtggagttt tgcagtgctt ctgtgggaac tggtgacacg ggaggtaccc     1380

tttgctgacc tctccaatat ggagattgga atgaaggtgg cattggaagg ccttcggcct     1440

accatcccac caggtatttc ccctcatgtg tgtaagctca tgaagatctg catgaatgaa     1500

gaccctgcaa agcgacccaa atttgacatg attgtgccta tccttgagaa gatgcaggac     1560

aagtaggact ggaaggtcct tgcctgaact ccagaggtgt cgggacatgg ttgggggaat     1620

gcacctcccc aaagcagcag gcctctggtt gcctcccccg cctccagtca tggtactacc     1680

ccagccatgg ggtccatccc cttcccccat ccctaccact gtggccccaa gaggggcggg     1740

ctcagagctt tgtcacttgc cacatggtgt ctcccaacat gggagggatc agccccgcct     1800

gtcacaataa agtttattat gaaaacagga aaaaaaaaaa aaa                       1843


<210>  32
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Asp Asp Ile Phe Thr Gln Cys Arg Glu Gly Asn Ala Val Ala Val 
1               5                   10                  15      


Arg Leu Trp Leu Asp Asn Thr Glu Asn Asp Leu Asn Gln Gly Asp Asp 
            20                  25                  30          


His Gly Phe Ser Pro Leu His Trp Ala Cys Arg Glu Gly Arg Ser Ala 
        35                  40                  45              


Val Val Glu Met Leu Ile Met Arg Gly Ala Arg Ile Asn Val Met Asn 
    50                  55                  60                  


Arg Gly Asp Asp Thr Pro Leu His Leu Ala Ala Ser His Gly His Arg 
65                  70                  75                  80  


Asp Ile Val Gln Lys Leu Leu Gln Tyr Lys Ala Asp Ile Asn Ala Val 
                85                  90                  95      


Asn Glu His Gly Asn Val Pro Leu His Tyr Ala Cys Phe Trp Gly Gln 
            100                 105                 110         


Asp Gln Val Ala Glu Asp Leu Val Ala Asn Gly Ala Leu Val Ser Ile 
        115                 120                 125             


Cys Asn Lys Tyr Gly Glu Met Pro Val Asp Lys Ala Lys Ala Pro Leu 
    130                 135                 140                 


Arg Glu Leu Leu Arg Glu Arg Ala Glu Lys Met Gly Gln Asn Leu Asn 
145                 150                 155                 160 


Arg Ile Pro Tyr Lys Asp Thr Phe Trp Lys Gly Thr Thr Arg Thr Arg 
                165                 170                 175     


Pro Arg Asn Gly Thr Leu Asn Lys His Ser Gly Ile Asp Phe Lys Gln 
            180                 185                 190         


Leu Asn Phe Leu Thr Lys Leu Asn Glu Asn His Ser Gly Glu Leu Trp 
        195                 200                 205             


Lys Gly Arg Trp Gln Gly Asn Asp Ile Val Val Lys Val Leu Lys Val 
    210                 215                 220                 


Arg Asp Trp Ser Thr Arg Lys Ser Arg Asp Phe Asn Glu Glu Cys Pro 
225                 230                 235                 240 


Arg Leu Arg Ile Phe Ser His Pro Asn Val Leu Pro Val Leu Gly Ala 
                245                 250                 255     


Cys Gln Ser Pro Pro Ala Pro His Pro Thr Leu Ile Thr His Trp Met 
            260                 265                 270         


Pro Tyr Gly Ser Leu Tyr Asn Val Leu His Glu Gly Thr Asn Phe Val 
        275                 280                 285             


Val Asp Gln Ser Gln Ala Val Lys Phe Ala Leu Asp Met Ala Arg Gly 
    290                 295                 300                 


Met Ala Phe Leu His Thr Leu Glu Pro Leu Ile Pro Arg His Ala Leu 
305                 310                 315                 320 


Asn Ser Arg Ser Val Met Ile Asp Glu Asp Met Thr Ala Arg Ile Ser 
                325                 330                 335     


Met Ala Asp Val Lys Phe Ser Phe Gln Cys Pro Gly Arg Met Tyr Ala 
            340                 345                 350         


Pro Ala Trp Val Ala Pro Glu Ala Leu Gln Lys Lys Pro Glu Asp Thr 
        355                 360                 365             


Asn Arg Arg Ser Ala Asp Met Trp Ser Phe Ala Val Leu Leu Trp Glu 
    370                 375                 380                 


Leu Val Thr Arg Glu Val Pro Phe Ala Asp Leu Ser Asn Met Glu Ile 
385                 390                 395                 400 


Gly Met Lys Val Ala Leu Glu Gly Leu Arg Pro Thr Ile Pro Pro Gly 
                405                 410                 415     


Ile Ser Pro His Val Cys Lys Leu Met Lys Ile Cys Met Asn Glu Asp 
            420                 425                 430         


Pro Ala Lys Arg Pro Lys Phe Asp Met Ile Val Pro Ile Leu Glu Lys 
        435                 440                 445             


Met Gln Asp Lys 
    450         


<210>  33
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Asp Asp Ile Phe Thr Gln Cys Arg Glu Gly Asn Ala Val Ala Val 
1               5                   10                  15      


Arg Leu Trp Leu Asp Asn Thr Glu Asn Asp Leu Asn Gln Gly Asp Asp 
            20                  25                  30          


His Gly Phe Ser Pro Leu His Trp Ala Cys Arg Glu Gly Arg Ser Ala 
        35                  40                  45              


Val Val Glu Met Leu Ile Met Arg Gly Ala Arg Ile Asn Val Met Asn 
    50                  55                  60                  


Arg Gly Asp Asp Thr Pro Leu His Leu Ala Ala Ser His Gly His Arg 
65                  70                  75                  80  


Asp Ile Val Gln Lys Leu Leu Gln Tyr Lys Ala Asp Ile Asn Ala Val 
                85                  90                  95      


Asn Glu His Gly Asn Val Pro Leu His Tyr Ala Cys Phe Trp Gly Gln 
            100                 105                 110         


Asp Gln Val Ala Glu Asp Leu Val Ala Asn Gly Ala Leu Val Ser Ile 
        115                 120                 125             


Cys Asn Lys Tyr Gly Glu Met Pro Val Asp Lys Ala Lys Ala Pro Leu 
    130                 135                 140                 


Arg Glu Leu Leu Arg Glu Arg Ala Glu Lys Met Gly Gln Asn Leu Asn 
145                 150                 155                 160 


Arg Ile Pro Tyr Lys Asp Thr Phe Trp Lys Gly Thr Thr Arg Thr Arg 
                165                 170                 175     


Pro Arg Asn Gly Thr Leu Asn Lys His Ser Gly Ile Asp Phe Lys Gln 
            180                 185                 190         


Leu Asn Phe Leu Thr Lys Leu Asn Glu Asn His Ser Gly Glu Leu Trp 
        195                 200                 205             


Lys Gly Arg Trp Gln Gly Asn Asp Ile Val Val Lys Val Leu Lys Val 
    210                 215                 220                 


Arg Asp Trp Ser Thr Arg Lys Ser Arg Asp Phe Asn Glu Glu Cys Pro 
225                 230                 235                 240 


Arg Leu Arg Ile Phe Ser His Pro Asn Val Leu Pro Val Leu Gly Ala 
                245                 250                 255     


Cys Gln Ser Pro Pro Ala Pro His Pro Thr Leu Ile Thr His Trp Met 
            260                 265                 270         


Pro Tyr Gly Ser Leu Tyr Asn Val Leu His Glu Gly Thr Asn Phe Val 
        275                 280                 285             


Val Asp Gln Ser Gln Ala Val Lys Phe Ala Leu Asp Met Ala Arg Gly 
    290                 295                 300                 


Met Ala Phe Leu His Thr Leu Glu Pro Leu Ile Pro Arg His Ala Leu 
305                 310                 315                 320 


Asn Ser Arg Ser Val Met Ile Asp Glu Asp Met Thr Ala Arg Ile Ser 
                325                 330                 335     


Met Ala Asp Val Lys Phe Ser Phe Gln Cys Pro Gly Arg Met Tyr Ala 
            340                 345                 350         


Pro Ala Trp Val Ala Pro Glu Ala Leu Gln Lys Lys Pro Glu Asp Thr 
        355                 360                 365             


Asn Arg Arg Ser Ala Asp Met Trp Ser Phe Ala Val Leu Leu Trp Glu 
    370                 375                 380                 


Leu Val Thr Arg Glu Val Pro Phe Ala Asp Leu Ser Asn Met Glu Ile 
385                 390                 395                 400 


Gly Met Lys Val Ala Leu Glu Gly Leu Arg Pro Thr Ile Pro Pro Gly 
                405                 410                 415     


Ile Ser Pro His Val Cys Lys Leu Met Lys Ile Cys Met Asn Glu Asp 
            420                 425                 430         


Pro Ala Lys Arg Pro Lys Phe Asp Met Ile Val Pro Ile Leu Glu Lys 
        435                 440                 445             


Met Gln Asp Lys 
    450         


<210>  34
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Asp Asp Ile Phe Thr Gln Cys Arg Glu Gly Asn Ala Val Ala Val 
1               5                   10                  15      


Arg Leu Trp Leu Asp Asn Thr Glu Asn Asp Leu Asn Gln Gly Asp Asp 
            20                  25                  30          


His Gly Phe Ser Pro Leu His Trp Ala Cys Arg Glu Gly Arg Ser Ala 
        35                  40                  45              


Val Val Glu Met Leu Ile Met Arg Gly Ala Arg Ile Asn Val Met Asn 
    50                  55                  60                  


Arg Gly Asp Asp Thr Pro Leu His Leu Ala Ala Ser His Gly His Arg 
65                  70                  75                  80  


Asp Ile Val Gln Lys Leu Leu Gln Tyr Lys Ala Asp Ile Asn Ala Val 
                85                  90                  95      


Asn Glu His Gly Asn Val Pro Leu His Tyr Ala Cys Phe Trp Gly Gln 
            100                 105                 110         


Asp Gln Val Ala Glu Ser Gly Gln Arg Arg Trp Ala Arg Ile Ser Thr 
        115                 120                 125             


Val Phe His Thr Arg Thr His Ser Gly Arg Gly Pro Pro Ala Leu Gly 
    130                 135                 140                 


Pro Leu Trp Lys Gly Arg Trp Gln Gly Asn Asp Ile Val Val Lys Val 
145                 150                 155                 160 


Leu Lys Val Arg Asp Trp Ser Thr Arg Lys Ser Arg Asp Phe Asn Glu 
                165                 170                 175     


Glu Cys Pro Arg Leu Arg Ile Phe Ser His Pro Asn Val Leu Pro Val 
            180                 185                 190         


Leu Gly Ala Cys Gln Ser Pro Pro Ala Pro His Pro Thr Leu Ile Thr 
        195                 200                 205             


His Trp Met Pro Tyr Gly Ser Leu Tyr Asn Val Leu His Glu Gly Thr 
    210                 215                 220                 


Asn Phe Val Val Asp Gln Ser Gln Ala Val Lys Phe Ala Leu Asp Met 
225                 230                 235                 240 


Ala Arg Gly Met Ala Phe Leu His Thr Leu Glu Pro Leu Ile Pro Arg 
                245                 250                 255     


His Ala Leu Asn Ser Arg Ser Val Met Ile Asp Glu Asp Met Thr Ala 
            260                 265                 270         


Arg Ile Ser Met Ala Asp Val Lys Phe Ser Phe Gln Cys Pro Gly Arg 
        275                 280                 285             


Met Tyr Ala Pro Ala Trp Val Ala Pro Glu Ala Leu Gln Lys Lys Pro 
    290                 295                 300                 


Glu Asp Thr Asn Arg Arg Ser Ala Asp Met Trp Ser Phe Ala Val Leu 
305                 310                 315                 320 


Leu Trp Glu Leu Val Thr Arg Glu Val Pro Phe Ala Asp Leu Ser Asn 
                325                 330                 335     


Met Glu Ile Gly Met Lys Val Ala Leu Glu Gly Leu Arg Pro Thr Ile 
            340                 345                 350         


Pro Pro Gly Ile Ser Pro His Val Cys Lys Leu Met Lys Ile Cys Met 
        355                 360                 365             


Asn Glu Asp Pro Ala Lys Arg Pro Lys Phe Asp Met Ile Val Pro Ile 
    370                 375                 380                 


Leu Glu Lys Met Gln Asp Lys 
385                 390     


<210>  35
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Val Asp Lys Ala Lys Ala Pro Leu Arg Glu Leu Leu Arg Glu 
1               5                   10                  15      


Arg Ala Glu Lys Met Gly Gln Asn Leu Asn Arg Ile Pro Tyr Lys Asp 
            20                  25                  30          


Thr Phe Trp Lys Gly Thr Thr Arg Thr Arg Pro Arg Asn Gly Thr Leu 
        35                  40                  45              


Asn Lys His Ser Gly Ile Asp Phe Lys Gln Leu Asn Phe Leu Thr Lys 
    50                  55                  60                  


Leu Asn Glu Asn His Ser Gly Glu Leu Trp Lys Gly Arg Trp Gln Gly 
65                  70                  75                  80  


Asn Asp Ile Val Val Lys Val Leu Lys Val Arg Asp Trp Ser Thr Arg 
                85                  90                  95      


Lys Ser Arg Asp Phe Asn Glu Glu Cys Pro Arg Leu Arg Ile Phe Ser 
            100                 105                 110         


His Pro Asn Val Leu Pro Val Leu Gly Ala Cys Gln Ser Pro Pro Ala 
        115                 120                 125             


Pro His Pro Thr Leu Ile Thr His Trp Met Pro Tyr Gly Ser Leu Tyr 
    130                 135                 140                 


Asn Val Leu His Glu Gly Thr Asn Phe Val Val Asp Gln Ser Gln Ala 
145                 150                 155                 160 


Val Lys Phe Ala Leu Asp Met Ala Arg Gly Met Ala Phe Leu His Thr 
                165                 170                 175     


Leu Glu Pro Leu Ile Pro Arg His Ala Leu Asn Ser Arg Ser Val Met 
            180                 185                 190         


Ile Asp Glu Asp Met Thr Ala Arg Ile Ser Met Ala Asp Val Lys Phe 
        195                 200                 205             


Ser Phe Gln Cys Pro Gly Arg Met Tyr Ala Pro Ala Trp Val Ala Pro 
    210                 215                 220                 


Glu Ala Leu Gln Lys Lys Pro Glu Asp Thr Asn Arg Arg Ser Ala Asp 
225                 230                 235                 240 


Met Trp Ser Phe Ala Val Leu Leu Trp Glu Leu Val Thr Arg Glu Val 
                245                 250                 255     


Pro Phe Ala Asp Leu Ser Asn Met Glu Ile Gly Met Lys Val Ala Leu 
            260                 265                 270         


Glu Gly Leu Arg Pro Thr Ile Pro Pro Gly Ile Ser Pro His Val Cys 
        275                 280                 285             


Lys Leu Met Lys Ile Cys Met Asn Glu Asp Pro Ala Lys Arg Pro Lys 
    290                 295                 300                 


Phe Asp Met Ile Val Pro Ile Leu Glu Lys Met Gln Asp Lys 
305                 310                 315             


<210>  36
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Asp Asp Ile Phe Thr Gln Cys Arg Glu Gly Asn Ala Val Ala Val 
1               5                   10                  15      


Arg Leu Trp Leu Asp Asn Thr Glu Asn Asp Leu Asn Gln Gly Asp Asp 
            20                  25                  30          


His Gly Phe Ser Pro Leu His Trp Ala Cys Arg Glu Gly Arg Ser Ala 
        35                  40                  45              


Val Val Glu Met Leu Ile Met Arg Gly Ala Arg Ile Asn Val Met Asn 
    50                  55                  60                  


Arg Gly Asp Asp Thr Pro Leu His Leu Ala Ala Ser His Gly His Arg 
65                  70                  75                  80  


Asp Ile Val Gln Lys Leu Leu Gln Tyr Lys Ala Asp Ile Asn Ala Val 
                85                  90                  95      


Asn Glu His Gly Asn Val Pro Leu His Tyr Ala Cys Phe Trp Gly Gln 
            100                 105                 110         


Asp Gln Val Ala Glu Asp Leu Val Ala Asn Gly Ala Leu Val Ser Ile 
        115                 120                 125             


Cys Asn Lys Tyr Gly Glu Met Pro Val Asp Lys Ala Lys Ala Pro Leu 
    130                 135                 140                 


Arg Glu Leu Leu Arg Glu Arg Ala Glu Lys Met Gly Gln Asn Leu Asn 
145                 150                 155                 160 


Arg Ile Pro Tyr Lys Asp Thr Phe Trp Lys Gly Thr Thr Arg Thr Arg 
                165                 170                 175     


Pro Arg Asn Gly Thr Leu Asn Lys His Ser Gly Ile Asp Phe Lys Gln 
            180                 185                 190         


Leu Asn Phe Leu Thr Lys Leu Asn Glu Asn His Ser Gly Glu Leu Trp 
        195                 200                 205             


Lys Gly Arg Trp Gln Gly Asn Asp Ile Val Val Lys Val Leu Lys Val 
    210                 215                 220                 


Arg Asp Trp Ser Thr Arg Lys Ser Arg Asp Phe Asn Glu Glu Cys Pro 
225                 230                 235                 240 


Arg Leu Arg Ile Phe Ser His Pro Asn Val Leu Pro Val Leu Gly Ala 
                245                 250                 255     


Cys Gln Ser Pro Pro Ala Pro His Pro Thr Leu Ile Thr His Trp Met 
            260                 265                 270         


Pro Tyr Gly Ser Leu Tyr Asn Val Leu His Glu Gly Thr Asn Phe Val 
        275                 280                 285             


Val Asp Gln Ser Gln Ala Val Lys Phe Ala Leu Asp Met Ala Arg Gly 
    290                 295                 300                 


Met Ala Phe Leu His Thr Leu Glu Pro Leu Ile Pro Arg His Ala Leu 
305                 310                 315                 320 


Asn Ser Arg Ser Val Met Ile Asp Glu Asp Met Thr Ala Arg Ile Ser 
                325                 330                 335     


Met Ala Asp Val Lys Phe Ser Phe Gln Cys Pro Gly Arg Met Tyr Ala 
            340                 345                 350         


Pro Ala Trp Val Ala Pro Glu Ala Leu Gln Lys Lys Pro Glu Asp Thr 
        355                 360                 365             


Asn Arg Arg Ser Ala Asp Met Trp Ser Phe Ala Val Leu Leu Trp Glu 
    370                 375                 380                 


Leu Val Thr Arg Glu Val Pro Phe Ala Asp Leu Ser Asn Met Glu Ile 
385                 390                 395                 400 


Gly Met Lys Val Ala Leu Glu Gly Leu Arg Pro Thr Ile Pro Pro Gly 
                405                 410                 415     


Ile Ser Pro His Val Cys Lys Leu Met Lys Ile Cys Met Asn Glu Asp 
            420                 425                 430         


Pro Ala Lys Arg Pro Lys Phe Asp Met Ile Val Pro Ile Leu Glu Lys 
        435                 440                 445             


Met Gln Asp Lys 
    450         


<210>  37
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ILK_forward primer

<400>  37
catccaaatg tgctcccagt g                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ILK_reverse primer

<400>  38
tggctctggt ccacgacgaa                                                   20


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ILK probe

<400>  39
tgcctgccag tctccacctg ct                                                22


<210>  40
<211>  1861
<212>  DNA
<213>  Homo sapiens

<400>  40
cactcaaggt gtgcaggcag ctgtgtttgt caggaaggca gaaggagttg gctttgcttt       60

aggggaggag acgaggtccc acaacaccct ctgaagggta tataaggagc cccagcgtgc      120

agcctggcct ggtacctcct gccagcatct cttgggtttg ctgagaactc acgggctcca      180

gctacctggc catgaccacc acatttctgc aaacttcttc ctccaccttt gggggtggct      240

caacccgagg gggttccctc ctggctgggg gaggtggctt tggtgggggg agtctctctg      300

ggggaggtgg aagccgaagt atctcagctt cttctgctag gtttgtctct tcagggtcag      360

gaggaggata tgggggtggc atgagggtct gtggctttgg tggaggggct ggtagtgttt      420

tcggtggagg ctttggaggg ggcgttggtg ggggttttgg tggtggcttt ggtggtggcg      480

atggtggtct cctctctggc aatgagaaaa ttaccatgca gaacctcaat gaccgcctgg      540

cctcctacct ggacaaggta cgtgccctgg aggaggccaa tgctgacctg gaggtgaaga      600

tccatgactg gtaccagaag cagaccccaa ccagcccaga atgcgactac agccaatact      660

tcaagaccat tgaagagctc cgggacaaga tcatggccac caccatcgac aactcccggg      720

tcatcctgga gatcgacaat gccaggctgg ctgcggacga cttcaggctc aagtatgaga      780

atgagctggc cctgcgccag ggcgttgagg ctgacatcaa cggcttgcgc cgagtcctgg      840

atgagctgac cctggccagg actgacctgg agatgcagat cgagggcctg aatgaggagc      900

tagcctacct gaagaagaac cacgaagagg agatgaagga gttcagcagc cagctggccg      960

gccaggtcaa tgtggagatg gacgcagcac cgggtgtgga cctgacccgt gtgctggcag     1020

agatgaggga gcagtacgag gccatggcgg agaagaaccg ccgggatgtc gaggcctggt     1080

tcttcagcaa gactgaggag ctgaacaaag aggtggcctc caacacagaa atgatccaga     1140

ccagcaagac ggagatcaca gacctgagac gcacgatgca ggagctggag atcgagctgc     1200

agtcccagct cagcatgaaa gctgggctgg agaactcact ggccgagaca gagtgccgct     1260

atgccacgca gctgcagcag atccaggggc tcattggtgg cctggaggcc cagctgagtg     1320

agctccgatg cgagatggag gctcagaacc aggagtacaa gatgctgctt gacataaaga     1380

cacggctgga gcaggagatc gctacttacc gcagcctgct cgagggccag gatgccaaga     1440

tggctggcat tggcatcagg gaagcctctt caggaggtgg tggtagcagc agcaatttcc     1500

acatcaatgt agaagagtca gtggatggac aggtggtttc ttcccacaag agagaaatct     1560

aagtgtctat tgcaggagaa acgtcccttg ccactcccca ctctcatcag gccaagtgga     1620

ggactggcca gagggcctgc acatgcaaac tccagtccct gccttcagag agctgaaaag     1680

ggtccctcgg tcttttattt cagggctttg catgcgctct attccccctc tgcctctccc     1740

caccttcttt ggagcaagga gatgcagctg tattgtgtaa caagctcatt tgtacagtgt     1800

ctgttcatgt aataaagaat tacttttcct tttgcaaata aaaaaaaaaa aaaaaaaaaa     1860

a                                                                     1861


<210>  41
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Thr Thr Thr Phe Leu Gln Thr Ser Ser Ser Thr Phe Gly Gly Gly 
1               5                   10                  15      


Ser Thr Arg Gly Gly Ser Leu Leu Ala Gly Gly Gly Gly Phe Gly Gly 
            20                  25                  30          


Gly Ser Leu Ser Gly Gly Gly Gly Ser Arg Ser Ile Ser Ala Ser Ser 
        35                  40                  45              


Ala Arg Phe Val Ser Ser Gly Ser Gly Gly Gly Tyr Gly Gly Gly Met 
    50                  55                  60                  


Arg Val Cys Gly Phe Gly Gly Gly Ala Gly Ser Val Phe Gly Gly Gly 
65                  70                  75                  80  


Phe Gly Gly Gly Val Gly Gly Gly Phe Gly Gly Gly Phe Gly Gly Gly 
                85                  90                  95      


Asp Gly Gly Leu Leu Ser Gly Asn Glu Lys Ile Thr Met Gln Asn Leu 
            100                 105                 110         


Asn Asp Arg Leu Ala Ser Tyr Leu Asp Lys Val Arg Ala Leu Glu Glu 
        115                 120                 125             


Ala Asn Ala Asp Leu Glu Val Lys Ile His Asp Trp Tyr Gln Lys Gln 
    130                 135                 140                 


Thr Pro Thr Ser Pro Glu Cys Asp Tyr Ser Gln Tyr Phe Lys Thr Ile 
145                 150                 155                 160 


Glu Glu Leu Arg Asp Lys Ile Met Ala Thr Thr Ile Asp Asn Ser Arg 
                165                 170                 175     


Val Ile Leu Glu Ile Asp Asn Ala Arg Leu Ala Ala Asp Asp Phe Arg 
            180                 185                 190         


Leu Lys Tyr Glu Asn Glu Leu Ala Leu Arg Gln Gly Val Glu Ala Asp 
        195                 200                 205             


Ile Asn Gly Leu Arg Arg Val Leu Asp Glu Leu Thr Leu Ala Arg Thr 
    210                 215                 220                 


Asp Leu Glu Met Gln Ile Glu Gly Leu Asn Glu Glu Leu Ala Tyr Leu 
225                 230                 235                 240 


Lys Lys Asn His Glu Glu Glu Met Lys Glu Phe Ser Ser Gln Leu Ala 
                245                 250                 255     


Gly Gln Val Asn Val Glu Met Asp Ala Ala Pro Gly Val Asp Leu Thr 
            260                 265                 270         


Arg Val Leu Ala Glu Met Arg Glu Gln Tyr Glu Ala Met Ala Glu Lys 
        275                 280                 285             


Asn Arg Arg Asp Val Glu Ala Trp Phe Phe Ser Lys Thr Glu Glu Leu 
    290                 295                 300                 


Asn Lys Glu Val Ala Ser Asn Thr Glu Met Ile Gln Thr Ser Lys Thr 
305                 310                 315                 320 


Glu Ile Thr Asp Leu Arg Arg Thr Met Gln Glu Leu Glu Ile Glu Leu 
                325                 330                 335     


Gln Ser Gln Leu Ser Met Lys Ala Gly Leu Glu Asn Ser Leu Ala Glu 
            340                 345                 350         


Thr Glu Cys Arg Tyr Ala Thr Gln Leu Gln Gln Ile Gln Gly Leu Ile 
        355                 360                 365             


Gly Gly Leu Glu Ala Gln Leu Ser Glu Leu Arg Cys Glu Met Glu Ala 
    370                 375                 380                 


Gln Asn Gln Glu Tyr Lys Met Leu Leu Asp Ile Lys Thr Arg Leu Glu 
385                 390                 395                 400 


Gln Glu Ile Ala Thr Tyr Arg Ser Leu Leu Glu Gly Gln Asp Ala Lys 
                405                 410                 415     


Met Ala Gly Ile Gly Ile Arg Glu Ala Ser Ser Gly Gly Gly Gly Ser 
            420                 425                 430         


Ser Ser Asn Phe His Ile Asn Val Glu Glu Ser Val Asp Gly Gln Val 
        435                 440                 445             


Val Ser Ser His Lys Arg Glu Ile 
    450                 455     


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRT15_forward primer

<400>  42
gctagcctac ctgaagaaga a                                                 21


<210>  43
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRT15_reverse primer

<400>  43
ccagctggct gctgaact                                                     18


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KRT15 probe

<400>  44
ccacgaagag gagatgaagg                                                   20


<210>  45
<211>  3123
<212>  DNA
<213>  Homo sapiens

<400>  45
ttggctacat cggacccaga tgactgcctc ctcacttcct ccctcccgat tccgccgcgg       60

cccccaaaga ctctcggggt ggccccttgt ccgcaccgct tggagggagt gtgctctgag      120

ttaagctggt ctcttctggt cctggaaaaa aatgagtatt gacaaggttg ctggatctgc      180

gcagaaaaga aagtgccact taataaaaaa tttagcccgg cagtggtacc gtctgcagag      240

cttgctgccc ttggacgtta gcaggaagcc ttcggggtgc tgtaatcggc gggcagagga      300

gagggaggcc gcggaattaa aaggaacaaa agctagagcg ccatgccaaa cgtccccggc      360

aagacccagt taggcaggag ccgggagtga tgggaaaatg aactagaaca tattggagaa      420

ttgggagaag tctctttggt ttggaaaaaa aaaaaaggaa tcttcagcct agatcacttt      480

cttatccgga ctgggatatt aaatatacga cacatccagg agtttattgg agcgcagact      540

gatggcgcaa aggtacgatg agctgcccca ttacggcggg atggacggag taggggttcc      600

cgcttccatg tacggagacc ctcacgcgcc gcggccgatc cccccggttc accacctgaa      660

ccacgggccg ccgctccacg ccacacagca ctacggcgcg cacgccccgc accccaatgt      720

catgccggcc agtatgggat ccgctgtcaa cgacgccttg aagcgggaca aggacgcgat      780

ctatgggcac ccgttgtttc ctctgttagc tctggtcttt gagaagtgcg agctggcgac      840

ctgcactccc cgggaacctg gagtggctgg cggagacgtc tgctcctccg actccttcaa      900

cgaggacatc gcggtcttcg ccaagcaggt tcgcgccgaa aagccacttt tttcctcaaa      960

tccagagctg gacaatttga tgatacaagc aatacaagta ctaaggtttc atcttttgga     1020

gttagaaaag gtccacgaac tgtgcgataa cttctgccac cgatacatta gctgtttgaa     1080

ggggaaaatg cccatcgacc tcgtcattga tgaaagagac ggcagctcca agtcagatca     1140

tgaagaactt tcaggctcct ccacaaatct cgctgaccat aacccttctt cttggcgaga     1200

ccacgatgat gcaacctcaa cccactcagc aggcacccca gggccctcca gtgggggcca     1260

tgcttcccag agcggagaca acagcagtga gcaaggggat ggtttagaca acagtgtagc     1320

ttcacctggt acaggtgacg atgatgatcc ggataaggac aaaaaacgcc agaagaaaag     1380

aggcattttc cccaaagtag caacaaatat catgagagca tggctcttcc agcatctcac     1440

acatccgtac ccttccgaag agcagaagaa acagttagcg caagacacag gacttacaat     1500

tctccaagta aacaactggt ttattaatgc cagaagaaga atagtacagc ccatgattga     1560

ccagtcaaat cgagcagtga gccaaggagc agcatatagt ccagagggtc agcccatggg     1620

gagctttgtg ttggatggtc agcaacacat ggggatccgg cctgcaggtt tgcagagcat     1680

gccaggggac tacgtttctc agggtggtcc tatgggaatg agtatggcac agccaagtta     1740

cactcctccc cagatgaccc cacaccctac tcaattaaga catggacccc caatgcattc     1800

atatttgcca agccatcccc accacccagc catgatgatg cacggaggac cccctaccca     1860

ccctggaatg actatgtcag cacagagccc cacaatgtta aattctgtag atcccaatgt     1920

tggcggacag gttatggaca ttcatgccca atagtataag ggaactcaag ggaaaaggaa     1980

acacacgcaa aaactatttt aagactttct gaactttgac cagatgttga cacttaatat     2040

gaaattccag acagctgtga ttatttttta cttttgtcat ttttcatcaa gcaacagagg     2100

accaatgcaa caagaacaca aatgtgaaat catgggctga ctgagacaat tctgtccatg     2160

taaagatcct ctggaaaaag actccgagag ttataactac tgtagtataa atataggaac     2220

taagttaaac ttgtacattt ctgttgatca cgccgttatg ttgcctcaaa tagttttaga     2280

agagaaaaaa aaatatatcc ttgttttcca cactatgtgt gttgttccca aaagaatgac     2340

tgttttggtt catcagtgaa ttcaccatcc aggagagact gtggtatata ttttaaacct     2400

gttgggccaa tgagaaaaga accacactgg agatcatgat gaacttttgg ctgaacctca     2460

tcactcgaac tccagcttca agaatgtgtt ttcatgcccg gcctttgttc ctccataaat     2520

gtgtccttta gtttcaaaca gatctttata gttcgtgctt cataagccaa ttcttattat     2580

tatttttggg ggactcttct tcaaagagct tgccaatgaa gatttaaaga cagagcagga     2640

gcttcttcca ggagttctga gccttggttg tggacaaaac aatcttaagt tgggcagctt     2700

tcctcaacac aaaaaaaagt tattaatggt cattgaacca taactaggac tttatcagaa     2760

actcaaagct tgggggataa aaaggagcaa gagaatactg taacaaactt cgtacagagt     2820

tcggtctatt aattgtttca tgttagatat tctatgtgtt tacctcaatt gaaaaaaaaa     2880

agaatgtttt tgctagtatc agatctgctg tggaattggt attgtatgtc catgaattct     2940

tcttttctca gcacgtgttc ctcactagaa gaaaatgctg ttacctttaa gctttgtcaa     3000

atttacatta aaatacttgt atgaggactg tgacgttatg ttaaaaaaaa aaaggtgtta     3060

agtcacaaaa agcggtaata aatatttcat ttttgatttt ttgttaaaaa aaaaaaaaaa     3120

aaa                                                                   3123


<210>  46
<211>  3074
<212>  DNA
<213>  Homo sapiens

<400>  46
ttggctacat cggacccaga tgactgcctc ctcacttcct ccctcccgat tccgccgcgg       60

cccccaaaga ctctcggggt ggccccttgt ccgcaccgct tggagggagt gtgctctgag      120

ttaagctggt ctcttctggt cctggaaaaa aatgagtatt gacaaggttg ctggatctgc      180

gcagaaaaga aagtgccact taataaaaaa tttagcccgg cagtggtacc gtctgcagag      240

cttgctgccc ttggacgtta gcaggaagcc ttcggggtgc tgtaatcggc gggcagagga      300

gagggaggcc gcggaattaa aaggaacaaa agctagagcg ccatgccaaa cgtccccggc      360

aagacccagt taggcaggag ccgggagtga tgggaaaatg aactagaata cgatgagctg      420

ccccattacg gcgggatgga cggagtaggg gttcccgctt ccatgtacgg agaccctcac      480

gcgccgcggc cgatcccccc ggttcaccac ctgaaccacg ggccgccgct ccacgccaca      540

cagcactacg gcgcgcacgc cccgcacccc aatgtcatgc cggccagtat gggatccgct      600

gtcaacgacg ccttgaagcg ggacaaggac gcgatctatg ggcacccgtt gtttcctctg      660

ttagctctgg tctttgagaa gtgcgagctg gcgacctgca ctccccggga acctggagtg      720

gctggcggag acgtctgctc ctccgactcc ttcaacgagg acatcgcggt cttcgccaag      780

caggttcgcg ccgaaaagcc acttttttcc tcaaatccag agctggacaa tttgatgata      840

caagcaatac aagtactaag gtttcatctt ttggagttag aaaaggtcca cgaactgtgc      900

gataacttct gccaccgata cattagctgt ttgaagggga aaatgcccat cgacctcgtc      960

attgatgaaa gagacggcag ctccaagtca gatcatgaag aactttcagg ctcctccaca     1020

aatctcgctg accataaccc ttcttcttgg cgagaccacg atgatgcaac ctcaacccac     1080

tcagcaggca ccccagggcc ctccagtggg ggccatgctt cccagagcgg agacaacagc     1140

agtgagcaag gggatggttt agacaacagt gtagcttcac ctggtacagg tgacgatgat     1200

gatccggata aggacaaaaa acgccagaag aaaagaggca ttttccccaa agtagcaaca     1260

aatatcatga gagcatggct cttccagcat ctcacacatc cgtacccttc cgaagagcag     1320

aagaaacagt tagcgcaaga cacaggactt acaattctcc aagtaaacaa ctggtttatt     1380

aatgccagaa gaagaatagt acagcccatg attgaccagt caaatcgagc agtgagccaa     1440

ggagcagcat atagtccaga gggtcagccc atggggagct ttgtgttgga tggtcagcaa     1500

cacatgggga tccggcctgc aggacctatg agtggaatgg gcatgaatat gggcatggat     1560

gggcaatggc actacatgta accttcatca tgtaaagcaa tcgcaaagca agggggaagt     1620

ttgcagagca tgccagggga ctacgtttct cagggtggtc ctatgggaat gagtatggca     1680

cagccaagtt acactcctcc ccagatgacc ccacacccta ctcaattaag acatggaccc     1740

ccaatgcatt catatttgcc aagccatccc caccacccag ccatgatgat gcacggagga     1800

ccccctaccc accctggaat gactatgtca gcacagagcc ccacaatgtt aaattctgta     1860

gatcccaatg ttggcggaca ggttatggac attcatgccc aatagtataa gggaactcaa     1920

gggaaaagga aacacacgca aaaactattt taagactttc tgaactttga ccagatgttg     1980

acacttaata tgaaattcca gacagctgtg attatttttt acttttgtca tttttcatca     2040

agcaacagag gaccaatgca acaagaacac aaatgtgaaa tcatgggctg actgagacaa     2100

ttctgtccat gtaaagatcc tctggaaaaa gactccgaga gttataacta ctgtagtata     2160

aatataggaa ctaagttaaa cttgtacatt tctgttgatc acgccgttat gttgcctcaa     2220

atagttttag aagagaaaaa aaaatatatc cttgttttcc acactatgtg tgttgttccc     2280

aaaagaatga ctgttttggt tcatcagtga attcaccatc caggagagac tgtggtatat     2340

attttaaacc tgttgggcca atgagaaaag aaccacactg gagatcatga tgaacttttg     2400

gctgaacctc atcactcgaa ctccagcttc aagaatgtgt tttcatgccc ggcctttgtt     2460

cctccataaa tgtgtccttt agtttcaaac agatctttat agttcgtgct tcataagcca     2520

attcttatta ttatttttgg gggactcttc ttcaaagagc ttgccaatga agatttaaag     2580

acagagcagg agcttcttcc aggagttctg agccttggtt gtggacaaaa caatcttaag     2640

ttgggcagct ttcctcaaca caaaaaaaag ttattaatgg tcattgaacc ataactagga     2700

ctttatcaga aactcaaagc ttgggggata aaaaggagca agagaatact gtaacaaact     2760

tcgtacagag ttcggtctat taattgtttc atgttagata ttctatgtgt ttacctcaat     2820

tgaaaaaaaa aagaatgttt ttgctagtat cagatctgct gtggaattgg tattgtatgt     2880

ccatgaattc ttcttttctc agcacgtgtt cctcactaga agaaaatgct gttaccttta     2940

agctttgtca aatttacatt aaaatacttg tatgaggact gtgacgttat gttaaaaaaa     3000

aaaaggtgtt aagtcacaaa aagcggtaat aaatatttca tttttgattt tttgttaaaa     3060

aaaaaaaaaa aaaa                                                       3074


<210>  47
<211>  3352
<212>  DNA
<213>  Homo sapiens

<400>  47
tttaaagaga gaggatcgta ttatagatac cgcgggggca aagctaaaaa aggggggagg       60

ggggaggaaa aaattcaaga agcagaaacc cctcgcggag ttttactgga agaaaaaaac      120

gggtctgaaa gattcctcct cttcatcatc atcaaccatc attcattcac taccttgaca      180

ttccgggctt tgattgacag ctggagtggc aaaaagccat gaaacacgac agttcggtta      240

catgtgggct gctgacgggc cgctcgtaac cttcagttcg ggggcttgac aatttttttc      300

ttctttttct tctttttctt ttctttcttt ttttttccaa ctgaggggaa gagaagagaa      360

agagggggaa aggaggaccg aagaggagga ggaggggagg ggggaggagg aggaggtgga      420

ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat      480

atcacagaaa aaaaaattct tcgttgtcta gactgggctt tttttccccc ctaaaaaata      540

gcatattgga gaattgggag aagtctcttt ggtttggaaa aaaaaaaaag gaatcttcag      600

cctagatcac tttcttatcc ggactgggat attaaatata cgacacatcc aggagtttat      660

tggagcgcag actgatggcg caaaggtacg atgagctgcc ccattacggc gggatggacg      720

gagtaggggt tcccgcttcc atgtacggag accctcacgc gccgcggccg atccccccgg      780

ttcaccacct gaaccacggg ccgccgctcc acgccacaca gcactacggc gcgcacgccc      840

cgcaccccaa tgtcatgccg gccagtatgg gatccgctgt caacgacgcc ttgaagcggg      900

acaaggacgc gatctatggg cacccgttgt ttcctctgtt agctctggtc tttgagaagt      960

gcgagctggc gacctgcact ccccgggaac ctggagtggc tggcggagac gtctgctcct     1020

ccgactcctt caacgaggac atcgcggtct tcgccaagca ggttcgcgcc gaaaagccac     1080

ttttttcctc aaatccagag ctggacaatt tgatgataca agcaatacaa gtactaaggt     1140

ttcatctttt ggagttagaa aaggtccacg aactgtgcga taacttctgc caccgataca     1200

ttagctgttt gaaggggaaa atgcccatcg acctcgtcat tgatgaaaga gacggcagct     1260

ccaagtcaga tcatgaagaa ctttcaggct cctccacaaa tctcgctgac cataaccctt     1320

cttcttggcg agaccacgat gatgcaacct caacccactc agcaggcacc ccagggccct     1380

ccagtggggg ccatgcttcc cagagcggag acaacagcag tgagcaaggg gatggtttag     1440

acaacagtgt agcttcacct ggtacaggtg acgatgatga tccggataag gacaaaaaac     1500

gccagaagaa aagaggcatt ttccccaaag tagcaacaaa tatcatgaga gcatggctct     1560

tccagcatct cacacatccg tacccttccg aagagcagaa gaaacagtta gcgcaagaca     1620

caggacttac aattctccaa gtaaacaact ggtttattaa tgccagaaga agaatagtac     1680

agcccatgat tgaccagtca aatcgagcag tgagccaagg agcagcatat agtccagagg     1740

gtcagcccat ggggagcttt gtgttggatg gtcagcaaca catggggatc cggcctgcag     1800

gacctatgag tggaatgggc atgaatatgg gcatggatgg gcaatggcac tacatgtaac     1860

cttcatcatg taaagcaatc gcaaagcaag ggggaagttt gcagagcatg ccaggggact     1920

acgtttctca gggtggtcct atgggaatga gtatggcaca gccaagttac actcctcccc     1980

agatgacccc acaccctact caattaagac atggaccccc aatgcattca tatttgccaa     2040

gccatcccca ccacccagcc atgatgatgc acggaggacc ccctacccac cctggaatga     2100

ctatgtcagc acagagcccc acaatgttaa attctgtaga tcccaatgtt ggcggacagg     2160

ttatggacat tcatgcccaa tagtataagg gaactcaagg gaaaaggaaa cacacgcaaa     2220

aactatttta agactttctg aactttgacc agatgttgac acttaatatg aaattccaga     2280

cagctgtgat tattttttac ttttgtcatt tttcatcaag caacagagga ccaatgcaac     2340

aagaacacaa atgtgaaatc atgggctgac tgagacaatt ctgtccatgt aaagatcctc     2400

tggaaaaaga ctccgagagt tataactact gtagtataaa tataggaact aagttaaact     2460

tgtacatttc tgttgatcac gccgttatgt tgcctcaaat agttttagaa gagaaaaaaa     2520

aatatatcct tgttttccac actatgtgtg ttgttcccaa aagaatgact gttttggttc     2580

atcagtgaat tcaccatcca ggagagactg tggtatatat tttaaacctg ttgggccaat     2640

gagaaaagaa ccacactgga gatcatgatg aacttttggc tgaacctcat cactcgaact     2700

ccagcttcaa gaatgtgttt tcatgcccgg cctttgttcc tccataaatg tgtcctttag     2760

tttcaaacag atctttatag ttcgtgcttc ataagccaat tcttattatt atttttgggg     2820

gactcttctt caaagagctt gccaatgaag atttaaagac agagcaggag cttcttccag     2880

gagttctgag ccttggttgt ggacaaaaca atcttaagtt gggcagcttt cctcaacaca     2940

aaaaaaagtt attaatggtc attgaaccat aactaggact ttatcagaaa ctcaaagctt     3000

gggggataaa aaggagcaag agaatactgt aacaaacttc gtacagagtt cggtctatta     3060

attgtttcat gttagatatt ctatgtgttt acctcaattg aaaaaaaaaa gaatgttttt     3120

gctagtatca gatctgctgt ggaattggta ttgtatgtcc atgaattctt cttttctcag     3180

cacgtgttcc tcactagaag aaaatgctgt tacctttaag ctttgtcaaa tttacattaa     3240

aatacttgta tgaggactgt gacgttatgt taaaaaaaaa aaggtgttaa gtcacaaaaa     3300

gcggtaataa atatttcatt tttgattttt tgttaaaaaa aaaaaaaaaa aa             3352


<210>  48
<211>  3277
<212>  DNA
<213>  Homo sapiens

<400>  48
tttaaagaga gaggatcgta ttatagatac cgcgggggca aagctaaaaa aggggggagg       60

ggggaggaaa aaattcaaga agcagaaacc cctcgcggag ttttactgga agaaaaaaac      120

gggtctgaaa gattcctcct cttcatcatc atcaaccatc attcattcac taccttgaca      180

ttccgggctt tgattgacag ctggagtggc aaaaagccat gaaacacgac agttcggtta      240

catgtgggct gctgacgggc cgctcgtaac cttcagttcg ggggcttgac aatttttttc      300

ttctttttct tctttttctt ttctttcttt ttttttccaa ctgaggggaa gagaagagaa      360

agagggggaa aggaggaccg aagaggagga ggaggggagg ggggaggagg aggaggtgga      420

ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat      480

atcacagaaa aaaaaattct tcgttgtcta gactgggctt tttttccccc ctaaaaaata      540

gcatattgga gaattgggag aagtctcttt ggtttggaaa aaaaaaaaag gaatcttcag      600

cctagatcac tttcttatcc ggactgggat attaaatata cgacacatcc aggagtttat      660

tggagcgcag actgatggcg caaaggtacg atgagctgcc ccattacggc gggatggacg      720

gagtaggggt tcccgcttcc atgtacggag accctcacgc gccgcggccg atccccccgg      780

ttcaccacct gaaccacggg ccgccgctcc acgccacaca gcactacggc gcgcacgccc      840

cgcaccccaa tgtcatgccg gccagtatgg gatccgctgt caacgacgcc ttgaagcggg      900

acaaggacgc gatctatggg cacccgttgt ttcctctgtt agctctggtc tttgagaagt      960

gcgagctggc gacctgcact ccccgggaac ctggagtggc tggcggagac gtctgctcct     1020

ccgactcctt caacgaggac atcgcggtct tcgccaagca ggttcgcgcc gaaaagccac     1080

ttttttcctc aaatccagag ctggacaatt tgatgataca agcaatacaa gtactaaggt     1140

ttcatctttt ggagttagaa aaggtccacg aactgtgcga taacttctgc caccgataca     1200

ttagctgttt gaaggggaaa atgcccatcg acctcgtcat tgatgaaaga gacggcagct     1260

ccaagtcaga tcatgaagaa ctttcaggct cctccacaaa tctcgctgac cataaccctt     1320

cttcttggcg agaccacgat gatgcaacct caacccactc agcaggcacc ccagggccct     1380

ccagtggggg ccatgcttcc cagagcggag acaacagcag tgagcaaggg gatggtttag     1440

acaacagtgt agcttcacct ggtacaggtg acgatgatga tccggataag gacaaaaaac     1500

gccagaagaa aagaggcatt ttccccaaag tagcaacaaa tatcatgaga gcatggctct     1560

tccagcatct cacacatccg tacccttccg aagagcagaa gaaacagtta gcgcaagaca     1620

caggacttac aattctccaa gtaaacaact ggtttattaa tgccagaaga agaatagtac     1680

agcccatgat tgaccagtca aatcgagcag gttttcttct tgatccttca gtgagccaag     1740

gagcagcata tagtccagag ggtcagccca tggggagctt tgtgttggat ggtcagcaac     1800

acatggggat ccggcctgca ggtttgcaga gcatgccagg ggactacgtt tctcagggtg     1860

gtcctatggg aatgagtatg gcacagccaa gttacactcc tccccagatg accccacacc     1920

ctactcaatt aagacatgga cccccaatgc attcatattt gccaagccat ccccaccacc     1980

cagccatgat gatgcacgga ggacccccta cccaccctgg aatgactatg tcagcacaga     2040

gccccacaat gttaaattct gtagatccca atgttggcgg acaggttatg gacattcatg     2100

cccaatagta taagggaact caagggaaaa ggaaacacac gcaaaaacta ttttaagact     2160

ttctgaactt tgaccagatg ttgacactta atatgaaatt ccagacagct gtgattattt     2220

tttacttttg tcatttttca tcaagcaaca gaggaccaat gcaacaagaa cacaaatgtg     2280

aaatcatggg ctgactgaga caattctgtc catgtaaaga tcctctggaa aaagactccg     2340

agagttataa ctactgtagt ataaatatag gaactaagtt aaacttgtac atttctgttg     2400

atcacgccgt tatgttgcct caaatagttt tagaagagaa aaaaaaatat atccttgttt     2460

tccacactat gtgtgttgtt cccaaaagaa tgactgtttt ggttcatcag tgaattcacc     2520

atccaggaga gactgtggta tatattttaa acctgttggg ccaatgagaa aagaaccaca     2580

ctggagatca tgatgaactt ttggctgaac ctcatcactc gaactccagc ttcaagaatg     2640

tgttttcatg cccggccttt gttcctccat aaatgtgtcc tttagtttca aacagatctt     2700

tatagttcgt gcttcataag ccaattctta ttattatttt tgggggactc ttcttcaaag     2760

agcttgccaa tgaagattta aagacagagc aggagcttct tccaggagtt ctgagccttg     2820

gttgtggaca aaacaatctt aagttgggca gctttcctca acacaaaaaa aagttattaa     2880

tggtcattga accataacta ggactttatc agaaactcaa agcttggggg ataaaaagga     2940

gcaagagaat actgtaacaa acttcgtaca gagttcggtc tattaattgt ttcatgttag     3000

atattctatg tgtttacctc aattgaaaaa aaaaagaatg tttttgctag tatcagatct     3060

gctgtggaat tggtattgta tgtccatgaa ttcttctttt ctcagcacgt gttcctcact     3120

agaagaaaat gctgttacct ttaagctttg tcaaatttac attaaaatac ttgtatgagg     3180

actgtgacgt tatgttaaaa aaaaaaaggt gttaagtcac aaaaagcggt aataaatatt     3240

tcatttttga ttttttgtta aaaaaaaaaa aaaaaaa                              3277


<210>  49
<211>  3256
<212>  DNA
<213>  Homo sapiens

<400>  49
tttaaagaga gaggatcgta ttatagatac cgcgggggca aagctaaaaa aggggggagg       60

ggggaggaaa aaattcaaga agcagaaacc cctcgcggag ttttactgga agaaaaaaac      120

gggtctgaaa gattcctcct cttcatcatc atcaaccatc attcattcac taccttgaca      180

ttccgggctt tgattgacag ctggagtggc aaaaagccat gaaacacgac agttcggtta      240

catgtgggct gctgacgggc cgctcgtaac cttcagttcg ggggcttgac aatttttttc      300

ttctttttct tctttttctt ttctttcttt ttttttccaa ctgaggggaa gagaagagaa      360

agagggggaa aggaggaccg aagaggagga ggaggggagg ggggaggagg aggaggtgga      420

ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat      480

atcacagaaa aaaaaattct tcgttgtcta gactgggctt tttttccccc ctaaaaaata      540

gcatattgga gaattgggag aagtctcttt ggtttggaaa aaaaaaaaag gaatcttcag      600

cctagatcac tttcttatcc ggactgggat attaaatata cgacacatcc aggagtttat      660

tggagcgcag actgatggcg caaaggtacg atgagctgcc ccattacggc gggatggacg      720

gagtaggggt tcccgcttcc atgtacggag accctcacgc gccgcggccg atccccccgg      780

ttcaccacct gaaccacggg ccgccgctcc acgccacaca gcactacggc gcgcacgccc      840

cgcaccccaa tgtcatgccg gccagtatgg gatccgctgt caacgacgcc ttgaagcggg      900

acaaggacgc gatctatggg cacccgttgt ttcctctgtt agctctggtc tttgagaagt      960

gcgagctggc gacctgcact ccccgggaac ctggagtggc tggcggagac gtctgctcct     1020

ccgactcctt caacgaggac atcgcggtct tcgccaagca ggttcgcgcc gaaaagccac     1080

ttttttcctc aaatccagag ctggacaatt tgatgataca agcaatacaa gtactaaggt     1140

ttcatctttt ggagttagaa aaggtccacg aactgtgcga taacttctgc caccgataca     1200

ttagctgttt gaaggggaaa atgcccatcg acctcgtcat tgatgaaaga gacggcagct     1260

ccaagtcaga tcatgaagaa ctttcaggct cctccacaaa tctcgctgac cataaccctt     1320

cttcttggcg agaccacgat gatgcaacct caacccactc agcaggcacc ccagggccct     1380

ccagtggggg ccatgcttcc cagagcggag acaacagcag tgagcaaggg gatggtttag     1440

acaacagtgt agcttcacct ggtacaggtg acgatgatga tccggataag gacaaaaaac     1500

gccagaagaa aagaggcatt ttccccaaag tagcaacaaa tatcatgaga gcatggctct     1560

tccagcatct cacacatccg tacccttccg aagagcagaa gaaacagtta gcgcaagaca     1620

caggacttac aattctccaa gtaaacaact ggtttattaa tgccagaaga agaatagtac     1680

agcccatgat tgaccagtca aatcgagcag tgagccaagg agcagcatat agtccagagg     1740

gtcagcccat ggggagcttt gtgttggatg gtcagcaaca catggggatc cggcctgcag     1800

gtttgcagag catgccaggg gactacgttt ctcagggtgg tcctatggga atgagtatgg     1860

cacagccaag ttacactcct ccccagatga ccccacaccc tactcaatta agacatggac     1920

ccccaatgca ttcatatttg ccaagccatc cccaccaccc agccatgatg atgcacggag     1980

gaccccctac ccaccctgga atgactatgt cagcacagag ccccacaatg ttaaattctg     2040

tagatcccaa tgttggcgga caggttatgg acattcatgc ccaatagtat aagggaactc     2100

aagggaaaag gaaacacacg caaaaactat tttaagactt tctgaacttt gaccagatgt     2160

tgacacttaa tatgaaattc cagacagctg tgattatttt ttacttttgt catttttcat     2220

caagcaacag aggaccaatg caacaagaac acaaatgtga aatcatgggc tgactgagac     2280

aattctgtcc atgtaaagat cctctggaaa aagactccga gagttataac tactgtagta     2340

taaatatagg aactaagtta aacttgtaca tttctgttga tcacgccgtt atgttgcctc     2400

aaatagtttt agaagagaaa aaaaaatata tccttgtttt ccacactatg tgtgttgttc     2460

ccaaaagaat gactgttttg gttcatcagt gaattcacca tccaggagag actgtggtat     2520

atattttaaa cctgttgggc caatgagaaa agaaccacac tggagatcat gatgaacttt     2580

tggctgaacc tcatcactcg aactccagct tcaagaatgt gttttcatgc ccggcctttg     2640

ttcctccata aatgtgtcct ttagtttcaa acagatcttt atagttcgtg cttcataagc     2700

caattcttat tattattttt gggggactct tcttcaaaga gcttgccaat gaagatttaa     2760

agacagagca ggagcttctt ccaggagttc tgagccttgg ttgtggacaa aacaatctta     2820

agttgggcag ctttcctcaa cacaaaaaaa agttattaat ggtcattgaa ccataactag     2880

gactttatca gaaactcaaa gcttggggga taaaaaggag caagagaata ctgtaacaaa     2940

cttcgtacag agttcggtct attaattgtt tcatgttaga tattctatgt gtttacctca     3000

attgaaaaaa aaaagaatgt ttttgctagt atcagatctg ctgtggaatt ggtattgtat     3060

gtccatgaat tcttcttttc tcagcacgtg ttcctcacta gaagaaaatg ctgttacctt     3120

taagctttgt caaatttaca ttaaaatact tgtatgagga ctgtgacgtt atgttaaaaa     3180

aaaaaaggtg ttaagtcaca aaaagcggta ataaatattt catttttgat tttttgttaa     3240

aaaaaaaaaa aaaaaa                                                     3256


<210>  50
<211>  3373
<212>  DNA
<213>  Homo sapiens

<400>  50
tttaaagaga gaggatcgta ttatagatac cgcgggggca aagctaaaaa aggggggagg       60

ggggaggaaa aaattcaaga agcagaaacc cctcgcggag ttttactgga agaaaaaaac      120

gggtctgaaa gattcctcct cttcatcatc atcaaccatc attcattcac taccttgaca      180

ttccgggctt tgattgacag ctggagtggc aaaaagccat gaaacacgac agttcggtta      240

catgtgggct gctgacgggc cgctcgtaac cttcagttcg ggggcttgac aatttttttc      300

ttctttttct tctttttctt ttctttcttt ttttttccaa ctgaggggaa gagaagagaa      360

agagggggaa aggaggaccg aagaggagga ggaggggagg ggggaggagg aggaggtgga      420

ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat      480

atcacagaaa aaaaaattct tcgttgtcta gactgggctt tttttccccc ctaaaaaata      540

gcatattgga gaattgggag aagtctcttt ggtttggaaa aaaaaaaaag gaatcttcag      600

cctagatcac tttcttatcc ggactgggat attaaatata cgacacatcc aggagtttat      660

tggagcgcag actgatggcg caaaggtacg atgagctgcc ccattacggc gggatggacg      720

gagtaggggt tcccgcttcc atgtacggag accctcacgc gccgcggccg atccccccgg      780

ttcaccacct gaaccacggg ccgccgctcc acgccacaca gcactacggc gcgcacgccc      840

cgcaccccaa tgtcatgccg gccagtatgg gatccgctgt caacgacgcc ttgaagcggg      900

acaaggacgc gatctatggg cacccgttgt ttcctctgtt agctctggtc tttgagaagt      960

gcgagctggc gacctgcact ccccgggaac ctggagtggc tggcggagac gtctgctcct     1020

ccgactcctt caacgaggac atcgcggtct tcgccaagca ggttcgcgcc gaaaagccac     1080

ttttttcctc aaatccagag ctggacaatt tgatgataca agcaatacaa gtactaaggt     1140

ttcatctttt ggagttagaa aaggtccacg aactgtgcga taacttctgc caccgataca     1200

ttagctgttt gaaggggaaa atgcccatcg acctcgtcat tgatgaaaga gacggcagct     1260

ccaagtcaga tcatgaagaa ctttcaggct cctccacaaa tctcgctgac cataaccctt     1320

cttcttggcg agaccacgat gatgcaacct caacccactc agcaggcacc ccagggccct     1380

ccagtggggg ccatgcttcc cagagcggag acaacagcag tgagcaaggg gatggtttag     1440

acaacagtgt agcttcacct ggtacaggtg acgatgatga tccggataag gacaaaaaac     1500

gccagaagaa aagaggcatt ttccccaaag tagcaacaaa tatcatgaga gcatggctct     1560

tccagcatct cacacatccg tacccttccg aagagcagaa gaaacagtta gcgcaagaca     1620

caggacttac aattctccaa gtaaacaact ggtttattaa tgccagaaga agaatagtac     1680

agcccatgat tgaccagtca aatcgagcag gttttcttct tgatccttca gtgagccaag     1740

gagcagcata tagtccagag ggtcagccca tggggagctt tgtgttggat ggtcagcaac     1800

acatggggat ccggcctgca ggacctatga gtggaatggg catgaatatg ggcatggatg     1860

ggcaatggca ctacatgtaa ccttcatcat gtaaagcaat cgcaaagcaa gggggaagtt     1920

tgcagagcat gccaggggac tacgtttctc agggtggtcc tatgggaatg agtatggcac     1980

agccaagtta cactcctccc cagatgaccc cacaccctac tcaattaaga catggacccc     2040

caatgcattc atatttgcca agccatcccc accacccagc catgatgatg cacggaggac     2100

cccctaccca ccctggaatg actatgtcag cacagagccc cacaatgtta aattctgtag     2160

atcccaatgt tggcggacag gttatggaca ttcatgccca atagtataag ggaactcaag     2220

ggaaaaggaa acacacgcaa aaactatttt aagactttct gaactttgac cagatgttga     2280

cacttaatat gaaattccag acagctgtga ttatttttta cttttgtcat ttttcatcaa     2340

gcaacagagg accaatgcaa caagaacaca aatgtgaaat catgggctga ctgagacaat     2400

tctgtccatg taaagatcct ctggaaaaag actccgagag ttataactac tgtagtataa     2460

atataggaac taagttaaac ttgtacattt ctgttgatca cgccgttatg ttgcctcaaa     2520

tagttttaga agagaaaaaa aaatatatcc ttgttttcca cactatgtgt gttgttccca     2580

aaagaatgac tgttttggtt catcagtgaa ttcaccatcc aggagagact gtggtatata     2640

ttttaaacct gttgggccaa tgagaaaaga accacactgg agatcatgat gaacttttgg     2700

ctgaacctca tcactcgaac tccagcttca agaatgtgtt ttcatgcccg gcctttgttc     2760

ctccataaat gtgtccttta gtttcaaaca gatctttata gttcgtgctt cataagccaa     2820

ttcttattat tatttttggg ggactcttct tcaaagagct tgccaatgaa gatttaaaga     2880

cagagcagga gcttcttcca ggagttctga gccttggttg tggacaaaac aatcttaagt     2940

tgggcagctt tcctcaacac aaaaaaaagt tattaatggt cattgaacca taactaggac     3000

tttatcagaa actcaaagct tgggggataa aaaggagcaa gagaatactg taacaaactt     3060

cgtacagagt tcggtctatt aattgtttca tgttagatat tctatgtgtt tacctcaatt     3120

gaaaaaaaaa agaatgtttt tgctagtatc agatctgctg tggaattggt attgtatgtc     3180

catgaattct tcttttctca gcacgtgttc ctcactagaa gaaaatgctg ttacctttaa     3240

gctttgtcaa atttacatta aaatacttgt atgaggactg tgacgttatg ttaaaaaaaa     3300

aaaggtgtta agtcacaaaa agcggtaata aatatttcat ttttgatttt ttgttaaaaa     3360

aaaaaaaaaa aaa                                                        3373


<210>  51
<211>  2849
<212>  DNA
<213>  Homo sapiens

<400>  51
tcctcctcct ctcttctctc ttacctccct ccctctctct catctttatc ccttcctctc       60

ttttctgttc gccctcttct ccctgctctt tttccctttc cacccccctc ctctgttctc      120

cctcacctcc tgcgccccct cccccttccc gggttctgac agtacgatga gctgccccat      180

tacggcggga tggacggagt aggggttccc gcttccatgt acggagaccc tcacgcgccg      240

cggccgatcc ccccggttca ccacctgaac cacgggccgc cgctccacgc cacacagcac      300

tacggcgcgc acgccccgca ccccaatgtc atgccggcca gtatgggatc cgctgtcaac      360

gacgccttga agcgggacaa ggacgcgatc tatgggcacc cgttgtttcc tctgttagct      420

ctggtctttg agaagtgcga gctggcgacc tgcactcccc gggaacctgg agtggctggc      480

ggagacgtct gctcctccga ctccttcaac gaggacatcg cggtcttcgc caagcaggtt      540

cgcgccgaaa agccactttt ttcctcaaat ccagagctgg acaatttgat gatacaagca      600

atacaagtac taaggtttca tcttttggag ttagaaaagg tccacgaact gtgcgataac      660

ttctgccacc gatacattag ctgtttgaag gggaaaatgc ccatcgacct cgtcattgat      720

gaaagagacg gcagctccaa gtcagatcat gaagaacttt caggctcctc cacaaatctc      780

gctgaccata acccttcttc ttggcgagac cacgatgatg caacctcaac ccactcagca      840

ggcaccccag ggccctccag tgggggccat gcttcccaga gcggagacaa cagcagtgag      900

caaggggatg gtttagacaa cagtgtagct tcacctggta caggtgacga tgatgatccg      960

gataaggaca aaaaacgcca gaagaaaaga ggcattttcc ccaaagtagc aacaaatatc     1020

atgagagcat ggctcttcca gcatctcaca catccgtacc cttccgaaga gcagaagaaa     1080

cagttagcgc aagacacagg acttacaatt ctccaagtaa acaactggtt tattaatgcc     1140

agaagaagaa tagtacagcc catgattgac cagtcaaatc gagcaggttt tcttcttgat     1200

ccttcagtga gccaaggagc agcatatagt ccagagggtc agcccatggg gagctttgtg     1260

ttggatggtc agcaacacat ggggatccgg cctgcaggac ctatgagtgg aatgggcatg     1320

aatatgggca tggatgggca atggcactac atgtaacctt catcatgtaa agcaatcgca     1380

aagcaagggg gaagtttgca gagcatgcca ggggactacg tttctcaggg tggtcctatg     1440

ggaatgagta tggcacagcc aagttacact cctccccaga tgaccccaca ccctactcaa     1500

ttaagacatg gacccccaat gcattcatat ttgccaagcc atccccacca cccagccatg     1560

atgatgcacg gaggaccccc tacccaccct ggaatgacta tgtcagcaca gagccccaca     1620

atgttaaatt ctgtagatcc caatgttggc ggacaggtta tggacattca tgcccaatag     1680

tataagggaa ctcaagggaa aaggaaacac acgcaaaaac tattttaaga ctttctgaac     1740

tttgaccaga tgttgacact taatatgaaa ttccagacag ctgtgattat tttttacttt     1800

tgtcattttt catcaagcaa cagaggacca atgcaacaag aacacaaatg tgaaatcatg     1860

ggctgactga gacaattctg tccatgtaaa gatcctctgg aaaaagactc cgagagttat     1920

aactactgta gtataaatat aggaactaag ttaaacttgt acatttctgt tgatcacgcc     1980

gttatgttgc ctcaaatagt tttagaagag aaaaaaaaat atatccttgt tttccacact     2040

atgtgtgttg ttcccaaaag aatgactgtt ttggttcatc agtgaattca ccatccagga     2100

gagactgtgg tatatatttt aaacctgttg ggccaatgag aaaagaacca cactggagat     2160

catgatgaac ttttggctga acctcatcac tcgaactcca gcttcaagaa tgtgttttca     2220

tgcccggcct ttgttcctcc ataaatgtgt cctttagttt caaacagatc tttatagttc     2280

gtgcttcata agccaattct tattattatt tttgggggac tcttcttcaa agagcttgcc     2340

aatgaagatt taaagacaga gcaggagctt cttccaggag ttctgagcct tggttgtgga     2400

caaaacaatc ttaagttggg cagctttcct caacacaaaa aaaagttatt aatggtcatt     2460

gaaccataac taggacttta tcagaaactc aaagcttggg ggataaaaag gagcaagaga     2520

atactgtaac aaacttcgta cagagttcgg tctattaatt gtttcatgtt agatattcta     2580

tgtgtttacc tcaattgaaa aaaaaaagaa tgtttttgct agtatcagat ctgctgtgga     2640

attggtattg tatgtccatg aattcttctt ttctcagcac gtgttcctca ctagaagaaa     2700

atgctgttac ctttaagctt tgtcaaattt acattaaaat acttgtatga ggactgtgac     2760

gttatgttaa aaaaaaaaag gtgttaagtc acaaaaagcg gtaataaata tttcattttt     2820

gattttttgt taaaaaaaaa aaaaaaaaa                                       2849


<210>  52
<211>  0
<212>  DNA
<213>  Homo sapiens

<400>  52

000                                                           


<210>  53
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Gln Arg Tyr Asp Glu Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala Pro Arg Pro 
            20                  25                  30          


Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu His Ala Thr 
        35                  40                  45              


Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met Pro Ala Ser 
    50                  55                  60                  


Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile 
65                  70                  75                  80  


Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys 
                85                  90                  95      


Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp 
            100                 105                 110         


Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys 
        115                 120                 125             


Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp 
    130                 135                 140                 


Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile 
                165                 170                 175     


Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Glu Arg 
            180                 185                 190         


Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly Ser Ser Thr 
        195                 200                 205             


Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His Asp Asp Ala 
    210                 215                 220                 


Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser Gly Gly His 
225                 230                 235                 240 


Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp 
                245                 250                 255     


Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp Pro Asp Lys 
            260                 265                 270         


Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr 
        275                 280                 285             


Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro 
    290                 295                 300                 


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
305                 310                 315                 320 


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
                325                 330                 335     


Pro Met Ile Asp Gln Ser Asn Arg Ala Val Ser Gln Gly Ala Ala Tyr 
            340                 345                 350         


Ser Pro Glu Gly Gln Pro Met Gly Ser Phe Val Leu Asp Gly Gln Gln 
        355                 360                 365             


His Met Gly Ile Arg Pro Ala Gly Leu Gln Ser Met Pro Gly Asp Tyr 
    370                 375                 380                 


Val Ser Gln Gly Gly Pro Met Gly Met Ser Met Ala Gln Pro Ser Tyr 
385                 390                 395                 400 


Thr Pro Pro Gln Met Thr Pro His Pro Thr Gln Leu Arg His Gly Pro 
                405                 410                 415     


Pro Met His Ser Tyr Leu Pro Ser His Pro His His Pro Ala Met Met 
            420                 425                 430         


Met His Gly Gly Pro Pro Thr His Pro Gly Met Thr Met Ser Ala Gln 
        435                 440                 445             


Ser Pro Thr Met Leu Asn Ser Val Asp Pro Asn Val Gly Gly Gln Val 
    450                 455                 460                 


Met Asp Ile His Ala Gln 
465                 470 


<210>  54
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Asp Gly Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala 
1               5                   10                  15      


Pro Arg Pro Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu 
            20                  25                  30          


His Ala Thr Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met 
        35                  40                  45              


Pro Ala Ser Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys 
    50                  55                  60                  


Asp Ala Ile Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe 
65                  70                  75                  80  


Glu Lys Cys Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala 
                85                  90                  95      


Gly Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val 
            100                 105                 110         


Phe Ala Lys Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro 
        115                 120                 125             


Glu Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His 
    130                 135                 140                 


Leu Leu Glu Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His 
145                 150                 155                 160 


Arg Tyr Ile Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile 
                165                 170                 175     


Asp Glu Arg Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly 
            180                 185                 190         


Ser Ser Thr Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His 
        195                 200                 205             


Asp Asp Ala Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser 
    210                 215                 220                 


Gly Gly His Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp 
225                 230                 235                 240 


Gly Leu Asp Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp 
                245                 250                 255     


Pro Asp Lys Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys 
            260                 265                 270         


Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His 
        275                 280                 285             


Pro Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly 
    290                 295                 300                 


Leu Thr Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg 
305                 310                 315                 320 


Ile Val Gln Pro Met Ile Asp Gln Ser Asn Arg Ala Val Ser Gln Gly 
                325                 330                 335     


Ala Ala Tyr Ser Pro Glu Gly Gln Pro Met Gly Ser Phe Val Leu Asp 
            340                 345                 350         


Gly Gln Gln His Met Gly Ile Arg Pro Ala Gly Pro Met Ser Gly Met 
        355                 360                 365             


Gly Met Asn Met Gly Met Asp Gly Gln Trp His Tyr Met 
    370                 375                 380     


<210>  55
<211>  394
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Ala Gln Arg Tyr Asp Glu Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala Pro Arg Pro 
            20                  25                  30          


Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu His Ala Thr 
        35                  40                  45              


Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met Pro Ala Ser 
    50                  55                  60                  


Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile 
65                  70                  75                  80  


Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys 
                85                  90                  95      


Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp 
            100                 105                 110         


Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys 
        115                 120                 125             


Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp 
    130                 135                 140                 


Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile 
                165                 170                 175     


Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Glu Arg 
            180                 185                 190         


Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly Ser Ser Thr 
        195                 200                 205             


Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His Asp Asp Ala 
    210                 215                 220                 


Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser Gly Gly His 
225                 230                 235                 240 


Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp 
                245                 250                 255     


Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp Pro Asp Lys 
            260                 265                 270         


Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr 
        275                 280                 285             


Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro 
    290                 295                 300                 


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
305                 310                 315                 320 


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
                325                 330                 335     


Pro Met Ile Asp Gln Ser Asn Arg Ala Val Ser Gln Gly Ala Ala Tyr 
            340                 345                 350         


Ser Pro Glu Gly Gln Pro Met Gly Ser Phe Val Leu Asp Gly Gln Gln 
        355                 360                 365             


His Met Gly Ile Arg Pro Ala Gly Pro Met Ser Gly Met Gly Met Asn 
    370                 375                 380                 


Met Gly Met Asp Gly Gln Trp His Tyr Met 
385                 390                 


<210>  56
<211>  477
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Gln Arg Tyr Asp Glu Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala Pro Arg Pro 
            20                  25                  30          


Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu His Ala Thr 
        35                  40                  45              


Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met Pro Ala Ser 
    50                  55                  60                  


Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile 
65                  70                  75                  80  


Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys 
                85                  90                  95      


Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp 
            100                 105                 110         


Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys 
        115                 120                 125             


Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp 
    130                 135                 140                 


Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile 
                165                 170                 175     


Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Glu Arg 
            180                 185                 190         


Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly Ser Ser Thr 
        195                 200                 205             


Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His Asp Asp Ala 
    210                 215                 220                 


Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser Gly Gly His 
225                 230                 235                 240 


Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp 
                245                 250                 255     


Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp Pro Asp Lys 
            260                 265                 270         


Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr 
        275                 280                 285             


Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro 
    290                 295                 300                 


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
305                 310                 315                 320 


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
                325                 330                 335     


Pro Met Ile Asp Gln Ser Asn Arg Ala Gly Phe Leu Leu Asp Pro Ser 
            340                 345                 350         


Val Ser Gln Gly Ala Ala Tyr Ser Pro Glu Gly Gln Pro Met Gly Ser 
        355                 360                 365             


Phe Val Leu Asp Gly Gln Gln His Met Gly Ile Arg Pro Ala Gly Leu 
    370                 375                 380                 


Gln Ser Met Pro Gly Asp Tyr Val Ser Gln Gly Gly Pro Met Gly Met 
385                 390                 395                 400 


Ser Met Ala Gln Pro Ser Tyr Thr Pro Pro Gln Met Thr Pro His Pro 
                405                 410                 415     


Thr Gln Leu Arg His Gly Pro Pro Met His Ser Tyr Leu Pro Ser His 
            420                 425                 430         


Pro His His Pro Ala Met Met Met His Gly Gly Pro Pro Thr His Pro 
        435                 440                 445             


Gly Met Thr Met Ser Ala Gln Ser Pro Thr Met Leu Asn Ser Val Asp 
    450                 455                 460                 


Pro Asn Val Gly Gly Gln Val Met Asp Ile His Ala Gln 
465                 470                 475         


<210>  57
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Gln Arg Tyr Asp Glu Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala Pro Arg Pro 
            20                  25                  30          


Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu His Ala Thr 
        35                  40                  45              


Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met Pro Ala Ser 
    50                  55                  60                  


Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile 
65                  70                  75                  80  


Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys 
                85                  90                  95      


Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp 
            100                 105                 110         


Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys 
        115                 120                 125             


Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp 
    130                 135                 140                 


Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile 
                165                 170                 175     


Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Glu Arg 
            180                 185                 190         


Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly Ser Ser Thr 
        195                 200                 205             


Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His Asp Asp Ala 
    210                 215                 220                 


Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser Gly Gly His 
225                 230                 235                 240 


Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp 
                245                 250                 255     


Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp Pro Asp Lys 
            260                 265                 270         


Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr 
        275                 280                 285             


Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro 
    290                 295                 300                 


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
305                 310                 315                 320 


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
                325                 330                 335     


Pro Met Ile Asp Gln Ser Asn Arg Ala Val Ser Gln Gly Ala Ala Tyr 
            340                 345                 350         


Ser Pro Glu Gly Gln Pro Met Gly Ser Phe Val Leu Asp Gly Gln Gln 
        355                 360                 365             


His Met Gly Ile Arg Pro Ala Gly Leu Gln Ser Met Pro Gly Asp Tyr 
    370                 375                 380                 


Val Ser Gln Gly Gly Pro Met Gly Met Ser Met Ala Gln Pro Ser Tyr 
385                 390                 395                 400 


Thr Pro Pro Gln Met Thr Pro His Pro Thr Gln Leu Arg His Gly Pro 
                405                 410                 415     


Pro Met His Ser Tyr Leu Pro Ser His Pro His His Pro Ala Met Met 
            420                 425                 430         


Met His Gly Gly Pro Pro Thr His Pro Gly Met Thr Met Ser Ala Gln 
        435                 440                 445             


Ser Pro Thr Met Leu Asn Ser Val Asp Pro Asn Val Gly Gly Gln Val 
    450                 455                 460                 


Met Asp Ile His Ala Gln 
465                 470 


<210>  58
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Gln Arg Tyr Asp Glu Leu Pro His Tyr Gly Gly Met Asp Gly 
1               5                   10                  15      


Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala Pro Arg Pro 
            20                  25                  30          


Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu His Ala Thr 
        35                  40                  45              


Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met Pro Ala Ser 
    50                  55                  60                  


Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys Asp Ala Ile 
65                  70                  75                  80  


Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe Glu Lys Cys 
                85                  90                  95      


Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala Gly Gly Asp 
            100                 105                 110         


Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val Phe Ala Lys 
        115                 120                 125             


Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro Glu Leu Asp 
    130                 135                 140                 


Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His Arg Tyr Ile 
                165                 170                 175     


Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile Asp Glu Arg 
            180                 185                 190         


Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly Ser Ser Thr 
        195                 200                 205             


Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His Asp Asp Ala 
    210                 215                 220                 


Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser Gly Gly His 
225                 230                 235                 240 


Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp Gly Leu Asp 
                245                 250                 255     


Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp Pro Asp Lys 
            260                 265                 270         


Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys Val Ala Thr 
        275                 280                 285             


Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His Pro Tyr Pro 
    290                 295                 300                 


Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly Leu Thr Ile 
305                 310                 315                 320 


Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg Ile Val Gln 
                325                 330                 335     


Pro Met Ile Asp Gln Ser Asn Arg Ala Gly Phe Leu Leu Asp Pro Ser 
            340                 345                 350         


Val Ser Gln Gly Ala Ala Tyr Ser Pro Glu Gly Gln Pro Met Gly Ser 
        355                 360                 365             


Phe Val Leu Asp Gly Gln Gln His Met Gly Ile Arg Pro Ala Gly Pro 
    370                 375                 380                 


Met Ser Gly Met Gly Met Asn Met Gly Met Asp Gly Gln Trp His Tyr 
385                 390                 395                 400 


Met 
    


<210>  59
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Asp Gly Val Gly Val Pro Ala Ser Met Tyr Gly Asp Pro His Ala 
1               5                   10                  15      


Pro Arg Pro Ile Pro Pro Val His His Leu Asn His Gly Pro Pro Leu 
            20                  25                  30          


His Ala Thr Gln His Tyr Gly Ala His Ala Pro His Pro Asn Val Met 
        35                  40                  45              


Pro Ala Ser Met Gly Ser Ala Val Asn Asp Ala Leu Lys Arg Asp Lys 
    50                  55                  60                  


Asp Ala Ile Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Val Phe 
65                  70                  75                  80  


Glu Lys Cys Glu Leu Ala Thr Cys Thr Pro Arg Glu Pro Gly Val Ala 
                85                  90                  95      


Gly Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp Ile Ala Val 
            100                 105                 110         


Phe Ala Lys Gln Val Arg Ala Glu Lys Pro Leu Phe Ser Ser Asn Pro 
        115                 120                 125             


Glu Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg Phe His 
    130                 135                 140                 


Leu Leu Glu Leu Glu Lys Val His Glu Leu Cys Asp Asn Phe Cys His 
145                 150                 155                 160 


Arg Tyr Ile Ser Cys Leu Lys Gly Lys Met Pro Ile Asp Leu Val Ile 
                165                 170                 175     


Asp Glu Arg Asp Gly Ser Ser Lys Ser Asp His Glu Glu Leu Ser Gly 
            180                 185                 190         


Ser Ser Thr Asn Leu Ala Asp His Asn Pro Ser Ser Trp Arg Asp His 
        195                 200                 205             


Asp Asp Ala Thr Ser Thr His Ser Ala Gly Thr Pro Gly Pro Ser Ser 
    210                 215                 220                 


Gly Gly His Ala Ser Gln Ser Gly Asp Asn Ser Ser Glu Gln Gly Asp 
225                 230                 235                 240 


Gly Leu Asp Asn Ser Val Ala Ser Pro Gly Thr Gly Asp Asp Asp Asp 
                245                 250                 255     


Pro Asp Lys Asp Lys Lys Arg Gln Lys Lys Arg Gly Ile Phe Pro Lys 
            260                 265                 270         


Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Thr His 
        275                 280                 285             


Pro Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr Gly 
    290                 295                 300                 


Leu Thr Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg Arg 
305                 310                 315                 320 


Ile Val Gln Pro Met Ile Asp Gln Ser Asn Arg Ala Gly Phe Leu Leu 
                325                 330                 335     


Asp Pro Ser Val Ser Gln Gly Ala Ala Tyr Ser Pro Glu Gly Gln Pro 
            340                 345                 350         


Met Gly Ser Phe Val Leu Asp Gly Gln Gln His Met Gly Ile Arg Pro 
        355                 360                 365             


Ala Gly Pro Met Ser Gly Met Gly Met Asn Met Gly Met Asp Gly Gln 
    370                 375                 380                 


Trp His Tyr Met 
385             


<210>  60
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Leu Val Phe Glu Lys Cys Glu Leu Ala Thr Cys Thr Pro Arg 
1               5                   10                  15      


Glu Pro Gly Val Ala Gly Gly Asp Val Cys Ser Ser Asp Ser Phe Asn 
            20                  25                  30          


Glu Asp Ile Ala Val Phe Ala Lys Gln Val Arg Ala Glu Lys Pro Leu 
        35                  40                  45              


Phe Ser Ser Asn Pro Glu Leu Asp Asn Leu Met Ile Gln Ala Ile Gln 
    50                  55                  60                  


Val Leu Arg Phe His Leu Leu Glu Leu Glu Lys Val His Glu Leu Cys 
65                  70                  75                  80  


Asp Asn Phe Cys His Arg Tyr Ile Ser Cys Leu Lys Gly Lys Met Pro 
                85                  90                  95      


Ile Asp Leu Val Ile Asp Glu Arg Asp Gly Ser Ser Lys Ser Asp His 
            100                 105                 110         


Glu Glu Leu Ser Gly Ser Ser Thr Asn Leu Ala Asp His Asn Pro Ser 
        115                 120                 125             


Ser Trp Arg Asp His Asp Asp Ala Thr Ser Thr His Ser Ala Gly Thr 
    130                 135                 140                 


Pro Gly Pro Ser Ser Gly Gly His Ala Ser Gln Ser Gly Asp Asn Ser 
145                 150                 155                 160 


Ser Glu Gln Gly Asp Gly Leu Asp Asn Ser Val Ala Ser Pro Gly Thr 
                165                 170                 175     


Gly Asp Asp Asp Asp Pro Asp Lys Asp Lys Lys Arg Gln Lys Lys Arg 
            180                 185                 190         


Gly Ile Phe Pro Lys Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe 
        195                 200                 205             


Gln His Leu Thr His Pro Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu 
    210                 215                 220                 


Ala Gln Asp Thr Gly Leu Thr Ile Leu Gln Val Asn Asn Trp Phe Ile 
225                 230                 235                 240 


Asn Ala Arg Arg Arg Ile Val Gln Pro Met Ile Asp Gln Ser Asn Arg 
                245                 250                 255     


Ala Val Ser Gln Gly Ala Ala Tyr Ser Pro Glu Gly Gln Pro Met Gly 
            260                 265                 270         


Ser Phe Val Leu Asp Gly Gln Gln His Met Gly Ile Arg Pro Ala Gly 
        275                 280                 285             


Pro Met Ser Gly Met Gly Met Asn Met Gly Met Asp Gly Gln Trp His 
    290                 295                 300                 


Tyr Met 
305     


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEIS2_forward primer

<400>  61
tcaaatccag agctggacaa                                                   20


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEIS2_reverse primer

<400>  62
cccttcaaac agctaatgta tcg                                               23


<210>  63
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MEIS2 probe

<400>  63
aaaggtccac gaactgtgcg at                                                22


<210>  64
<211>  3930
<212>  DNA
<213>  Homo sapiens

<400>  64
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagactggac ccttgtcgaa actcctcctg gggaggaaca agccaagcag aatgccaact      300

cccagctgtc catcttgttc attgaaaaac ctcaaggagg aacagtgaaa gttggtgaag      360

atatcacctt catagccaaa gtcaaggctg aagatcttct gagaaaaccc actatcaaat      420

ggttcaaagg aaaatggatg gacctggcca gcaaagccgg gaagcacctt cagctgaagg      480

aaacctttga gaggcacagt cgggtgtaca catttgagat gcagatcatc aaggccaaag      540

ataactttgc aggaaattac agatgcgagg tcacctataa ggataagttt gacagctgtt      600

catttgatct tgaagtgcac gaatctactg ggactactcc aaacattgac atcagatctg      660

ctttcaagag aagtggagaa ggtcaagagg atgcaggaga acttgacttt agtggtctcc      720

tgaaacgtag ggaggtgaag cagcaggagg aagaacccca ggtggacgta tgggagttgc      780

tgaagaacgc gaaacccagt gagtacgaga agatcgcctt ccagtatgga atcaccgacc      840

tgcgcggcat gctcaagcga ctcaagcgca tgcgcagaga ggagaagaag agcgcagctt      900

ttgcaaaaat tcttgatcct gcatatcagg ttgacaaagg aggcagagtg aggtttgttg      960

tggagctggc agatccaaag ttggaggtga aatggtataa aaatggtcaa gaaattcgac     1020

ccagtaccaa atacatcttt gaacacaaag gatgccagag aatcctgttt atcaataact     1080

gtcagatgac agatgattca gagtattatg tgacagccgg tgatgagaaa tgttccactg     1140

agctcttcgt aagagagcct ccaattatgg tgaccaaaca gctggaagat acaactgctt     1200

attgtgggga gagagtggaa ttagaatgtg aggtgtctga agatgatgcc aatgtaaaat     1260

ggtttaagaa tggtgaagag attatccctg gtccaaaatc aagataccga attagagttg     1320

agggtaaaaa acacatcttg atcatagagg gagcaacaaa ggctgatgct gcagaatatt     1380

cagtaatgac aacaggagga caatcatctg ctaaacttag tgttgacttg aaacctctga     1440

agattttgac acctctgact gatcagactg taaatcttgg aaaagaaatc tgcctgaagt     1500

gtgaaatctc tgaaaacata ccaggaaaat ggactaaaaa tggcctacct gttcaggaga     1560

gtgaccgtct aaaggtggtt cacaagggaa ggatccacaa gttagtgata gccaatgccc     1620

tcactgaaga tgaaggtgat tatgtatttg cacctgatgc ctacaatgtt actctgcctg     1680

ccaaagttca tgttattgat cctcctaaga tcatcctgga tggtcttgat gctgacaaca     1740

cagtgacagt gattgcagga aacaagcttc gtcttgagat ccccatcagc ggagaaccac     1800

ctcctaaagc catgtggagc cggggagata aggctattat ggaaggcagt ggccggataa     1860

gaacagaatc ttaccctgat agcagcactc tggtcattga tatagctgaa agagatgact     1920

ctggtgttta ccacatcaat ctgaaaaacg aagctggaga ggcacatgca agcatcaagg     1980

ttaaagttgt ggacttccct gatcctccag tggcaccgac tgtgacagag gtgggagatg     2040

actggtgtat catgaactgg gagcctcctg cctacgacgg aggctctcca atcctaggat     2100

attttattga gaggaagaag aaacaaagct ccaggtggat gaggctgaat tttgatctct     2160

gcaaagaaac aacttttgag cccaagaaga tgattgaagg tgtggcctat gaggtccgca     2220

tctttgcagt caatgccatt ggcatctcca agcccagtat gccctccagg ccttttgttc     2280

ctttggctgt aacaagccct cctactcttc tgactgtgga ctctgtcact gacacgactg     2340

tcacgatgag gtggcgcccc ccagaccaca ttggtgcagc aggtttagat ggctatgtgc     2400

tagagtattg ctttgaagga agtacatcag caaaacagtc tgatgaaaat ggggaggctg     2460

cctatgatct gccagctgag gactggatag ttgcaaacaa agatctgatt gacaagacga     2520

agttcaccat cacaggtctg ccaacagatg caaagatctt tgtgcgtgtg aaggctgtta     2580

atgcagctgg tgccagcgag cccaagtact attctcagcc cattctcgtg aaggaaatca     2640

tagaacctcc aaagattcgc attccaagac acctgaagca aacctatatc cgcagagttg     2700

gagaagctgt caatctggtt atacctttcc agggaaaacc aagaccagaa ttaacttgga     2760

agaaggatgg tgcagaaatt gataagaatc aaataaacat tcgcaactct gagactgata     2820

caatcatatt tattagaaaa gcagagagga gccactctgg gaaatatgat ctgcaagtca     2880

aagtggacaa attcgtggag accgcatcaa ttgacatcca gatcattgac cgtccaggtc     2940

caccccaaat tgtgaagatt gaggatgtct ggggagaaaa tgtcgctctc acatggactc     3000

caccaaagga tgatggaaat gctgctatca caggctatac cattcagaag gctgacaaga     3060

agagcatgga atggtttact gtcattgagc attatcatcg aaccagtgcc accattactg     3120

aattggtcat agggaatgaa tattacttcc gggtcttttc tgaaaacatg tgtggcctca     3180

gtgaggatgc caccatgact aaagagagtg cagtgatcgc cagggatggt aaaatctaca     3240

aaaatccagt gtatgaagac tttgatttct cagaggcacc catgtttact cagcctttgg     3300

ttaacaccta tgccatagct ggttacaatg ccaccctaaa ctgcagtgtg agaggaaatc     3360

ctaagcctaa aataacctgg atgaaaaaca aagttgctat tgtggatgat ccaagataca     3420

ggatgttcag caaccaggga gtctgtaccc tggaaattcg caagcccagc ccctatgatg     3480

gaggcactta ctgctgcaaa gcagtcaatg accttgggac agtggagatt gaatgcaaac     3540

tggaggtgaa agtgatatat caaggagtaa atacccctgg acaaccagtc ttcctggagg     3600

ggcagcaaca ggtgggctct ccttctgcag actcctcttg caaggcgtac ctccaaacat     3660

aattgattcg tatctgcgag acttacactc aagcaatcct gaggaatact gagggagggc     3720

ctggctactg tctctctgca ctctgctgct ttgaaatctg gttgaaatga gaaaaagcat     3780

tttctgtttt cccaccaggc ccccaagtgt ggtctttttc tttcctccta atgttgaaga     3840

gaaaaaaaaa aaaaaaagtt tgcccagatt gcttaattaa aaattgcaaa caaaatctca     3900

tttgaagtca aaaaaaaaaa aaaaaaaaaa                                      3930


<210>  65
<211>  3919
<212>  DNA
<213>  Homo sapiens

<400>  65
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagactggac ccttgtcgaa actcctcctg gggaggaaca agccaagcag aatgccaact      300

cccagctgtc catcttgttc attgaaaaac ctcaaggagg aacagtgaaa gttggtgaag      360

atatcacctt catagccaaa gtcaaggctg aagatcttct gagaaaaccc actatcaaat      420

ggttcaaagg aaaatggatg gacctggcca gcaaagccgg gaagcacctt cagctgaagg      480

aaacctttga gaggcacagt cgggtgtaca catttgagat gcagatcatc aaggccaaag      540

ataactttgc aggaaattac agatgcgagg tcacctataa ggataagttt gacagctgtt      600

catttgatct tgaagtgcac gaatctactg ggactactcc aaacattgac atcagatctg      660

ctttcaagag aagtggagaa ggtcaagagg atgcaggaga acttgacttt agtggtctcc      720

tgaaacgtag ggaggtgaag cagcaggagg aagaacccca ggtggacgta tgggagttgc      780

tgaagaacgc gaaacccagt gagtacgaga agatcgcctt ccagtatgga atcaccgacc      840

tgcgcggcat gctcaagcga ctcaagcgca tgcgcagaga ggagaagaag agcgcagctt      900

ttgcaaaaat tcttgatcct gcatatcagg ttgacaaagg aggcagagtg aggtttgttg      960

tggagctggc agatccaaag ttggaggtga aatggtataa aaatggtcaa gaaattcgac     1020

ccagtaccaa atacatcttt gaacacaaag gatgccagag aatcctgttt atcaataact     1080

gtcagatgac agatgattca gagtattatg tgacagccgg tgatgagaaa tgttccactg     1140

agctcttcgt aagagagcct ccaattatgg tgaccaaaca gctggaagat acaactgctt     1200

attgtgggga gagagtggaa ttagaatgtg aggtgtctga agatgatgcc aatgtaaaat     1260

ggtttaagaa tggtgaagag attatccctg gtccaaaatc aagataccga attagagttg     1320

agggtaaaaa acacatcttg atcatagagg gagcaacaaa ggctgatgct gcagaatatt     1380

cagtaatgac aacaggagga caatcatctg ctaaacttag tgttgacttg aaacctctga     1440

agattttgac acctctgact gatcagactg taaatcttgg aaaagaaatc tgcctgaagt     1500

gtgaaatctc tgaaaacata ccaggaaaat ggactaaaaa tggcctacct gttcaggaga     1560

gtgaccgtct aaaggtggtt cacaagggaa ggatccacaa gttagtgata gccaatgccc     1620

tcactgaaga tgaaggtgat tatgtatttg cacctgatgc ctacaatgtt actctgcctg     1680

ccaaagttca tgttattgat cctcctaaga tcatcctgga tggtcttgat gctgacaaca     1740

cagtgacagt gattgcagga aacaagcttc gtcttgagat ccccatcagc ggagaaccac     1800

ctcctaaagc catgtggagc cggggagata aggctattat ggaaggcagt ggccggataa     1860

gaacagaatc ttaccctgat agcagcactc tggtcattga tatagctgaa agagatgact     1920

ctggtgttta ccacatcaat ctgaaaaacg aagctggaga ggcacatgca agcatcaagg     1980

ttaaagttgt ggacttccct gatcctccag tggcaccgac tgtgacagag gtgggagatg     2040

actggtgtat catgaactgg gagcctcctg cctacgacgg aggctctcca atcctaggat     2100

attttattga gaggaagaag aaacaaagct ccaggtggat gaggctgaat tttgatctct     2160

gcaaagaaac aacttttgag cccaagaaga tgattgaagg tgtggcctat gaggtccgca     2220

tctttgcagt caatgccatt ggcatctcca agcccagtat gccctccagg ccttttgttc     2280

ctttggctgt aacaagccct cctactcttc tgactgtgga ctctgtcact gacacgactg     2340

tcacgatgag gtggcgcccc ccagaccaca ttggtgcagc aggtttagat ggctatgtgc     2400

tagagtattg ctttgaagga actgaggact ggatagttgc aaacaaagat ctgattgaca     2460

agacgaagtt caccatcaca ggtctgccaa cagatgcaaa gatctttgtg cgtgtgaagg     2520

ctgttaatgc agctggtgcc agcgagccca agtactattc tcagcccatt ctcgtgaagg     2580

aaatcataga acctccaaag attcgcattc caagacacct gaagcaaacc tatatccgca     2640

gagttggaga agctgtcaat ctggttatac ctttccaggg aaaaccaaga ccagaattaa     2700

cttggaagaa ggatggtgca gaaattgata agaatcaaat aaacattcgc aactctgaga     2760

ctgatacaat catatttatt agaaaagcag agaggagcca ctctgggaaa tatgatctgc     2820

aagtcaaagt ggacaaattc gtggagaccg catcaattga catccagatc attgaccgtc     2880

caggtccacc ccaaattgtg aagattgagg atgtctgggg agaaaatgtc gctctcacat     2940

ggactccacc aaaggatgat ggaaatgctg ctatcacagg ctataccatt cagaaggctg     3000

acaagaagag catggaatgg tttactgtca ttgagcatta tcatcgaacc agtgccacca     3060

ttactgaatt ggtcataggg aatgaatatt acttccgggt cttttctgaa aacatgtgtg     3120

gcctcagtga ggatgccacc atgactaaag agagtgcagt gatcgccagg gatggtaaaa     3180

tctacaaaaa tccagtgtat gaagactttg atttctcaga ggcacccatg tttactcagc     3240

ctttggttaa cacctatgcc atagctggtt acaatgccac cctaaactgc agtgtgagag     3300

gaaatcctaa gcctaaaata acctggatga aaaacaaagt tgctattgtg gatgatccaa     3360

gatacaggat gttcagcaac cagggagtct gtaccctgga aattcgcaag cccagcccct     3420

atgatggagg cacttactgc tgcaaagcag tcaatgacct tgggacagtg gagattgaat     3480

gcaaactgga ggtgaaagtg atatatcaag gagtaaatac ccctggacaa ccagtcttcc     3540

tggaggggca gcaacagtca ttgcacaata aggatttttg aatgtataat atcatctaag     3600

gtgggctctc cttctgcaga ctcctcttgc aaggcgtacc tccaaacata attgattcgt     3660

atctgcgaga cttacactca agcaatcctg aggaatactg agggagggcc tggctactgt     3720

ctctctgcac tctgctgctt tgaaatctgg ttgaaatgag aaaaagcatt ttctgttttc     3780

ccaccaggcc cccaagtgtg gtctttttct ttcctcctaa tgttgaagag aaaaaaaaaa     3840

aaaaaagttt gcccagattg cttaattaaa aattgcaaac aaaatctcat ttgaagtcaa     3900

aaaaaaaaaa aaaaaaaaa                                                  3919


<210>  66
<211>  3883
<212>  DNA
<213>  Homo sapiens

<400>  66
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaacca agtaaagaga      180

aggaggccgg aactacacca gcaaaagact ggacccttgt cgaaactcct cctggggagg      240

aacaagccaa gcagaatgcc aactcccagc tgtccatctt gttcattgaa aaacctcaag      300

gaggaacagt gaaagttggt gaagatatca ccttcatagc caaagtcaag gctgaagatc      360

ttctgagaaa acccactatc aaatggttca aaggaaaatg gatggacctg gccagcaaag      420

ccgggaagca ccttcagctg aaggaaacct ttgagaggca cagtcgggtg tacacatttg      480

agatgcagat catcaaggcc aaagataact ttgcaggaaa ttacagatgc gaggtcacct      540

ataaggataa gtttgacagc tgttcatttg atcttgaagt gcacgaatct actgggacta      600

ctccaaacat tgacatcaga tctgctttca agagaagtgg agaaggtcaa gaggatgcag      660

gagaacttga ctttagtggt ctcctgaaac gtagggaggt gaagcagcag gaggaagaac      720

cccaggtgga cgtatgggag ttgctgaaga acgcgaaacc cagtgagtac gagaagatcg      780

ccttccagta tggaatcacc gacctgcgcg gcatgctcaa gcgactcaag cgcatgcgca      840

gagaggagaa gaagagcgca gcttttgcaa aaattcttga tcctgcatat caggttgaca      900

aaggaggcag agtgaggttt gttgtggagc tggcagatcc aaagttggag gtgaaatggt      960

ataaaaatgg tcaagaaatt cgacccagta ccaaatacat ctttgaacac aaaggatgcc     1020

agagaatcct gtttatcaat aactgtcaga tgacagatga ttcagagtat tatgtgacag     1080

ccggtgatga gaaatgttcc actgagctct tcgtaagaga gcctccaatt atggtgacca     1140

aacagctgga agatacaact gcttattgtg gggagagagt ggaattagaa tgtgaggtgt     1200

ctgaagatga tgccaatgta aaatggttta agaatggtga agagattatc cctggtccaa     1260

aatcaagata ccgaattaga gttgagggta aaaaacacat cttgatcata gagggagcaa     1320

caaaggctga tgctgcagaa tattcagtaa tgacaacagg aggacaatca tctgctaaac     1380

ttagtgttga cttgaaacct ctgaagattt tgacacctct gactgatcag actgtaaatc     1440

ttggaaaaga aatctgcctg aagtgtgaaa tctctgaaaa cataccagga aaatggacta     1500

aaaatggcct acctgttcag gagagtgacc gtctaaaggt ggttcacaag ggaaggatcc     1560

acaagttagt gatagccaat gccctcactg aagatgaagg tgattatgta tttgcacctg     1620

atgcctacaa tgttactctg cctgccaaag ttcatgttat tgatcctcct aagatcatcc     1680

tggatggtct tgatgctgac aacacagtga cagtgattgc aggaaacaag cttcgtcttg     1740

agatccccat cagcggagaa ccacctccta aagccatgtg gagccgggga gataaggcta     1800

ttatggaagg cagtggccgg ataagaacag aatcttaccc tgatagcagc actctggtca     1860

ttgatatagc tgaaagagat gactctggtg tttaccacat caatctgaaa aacgaagctg     1920

gagaggcaca tgcaagcatc aaggttaaag ttgtggactt ccctgatcct ccagtggcac     1980

cgactgtgac agaggtggga gatgactggt gtatcatgaa ctgggagcct cctgcctacg     2040

acggaggctc tccaatccta ggatatttta ttgagaggaa gaagaaacaa agctccaggt     2100

ggatgaggct gaattttgat ctctgcaaag aaacaacttt tgagcccaag aagatgattg     2160

aaggtgtggc ctatgaggtc cgcatctttg cagtcaatgc cattggcatc tccaagccca     2220

gtatgccctc caggcctttt gttcctttgg ctgtaacaag ccctcctact cttctgactg     2280

tggactctgt cactgacacg actgtcacga tgaggtggcg ccccccagac cacattggtg     2340

cagcaggttt agatggctat gtgctagagt attgctttga aggaactgag gactggatag     2400

ttgcaaacaa agatctgatt gacaagacga agttcaccat cacaggtctg ccaacagatg     2460

caaagatctt tgtgcgtgtg aaggctgtta atgcagctgg tgccagcgag cccaagtact     2520

attctcagcc cattctcgtg aaggaaatca tagaacctcc aaagattcgc attccaagac     2580

acctgaagca aacctatatc cgcagagttg gagaagctgt caatctggtt atacctttcc     2640

agggaaaacc aagaccagaa ttaacttgga agaaggatgg tgcagaaatt gataagaatc     2700

aaataaacat tcgcaactct gagactgata caatcatatt tattagaaaa gcagagagga     2760

gccactctgg gaaatatgat ctgcaagtca aagtggacaa attcgtggag accgcatcaa     2820

ttgacatcca gatcattgac cgtccaggtc caccccaaat tgtgaagatt gaggatgtct     2880

ggggagaaaa tgtcgctctc acatggactc caccaaagga tgatggaaat gctgctatca     2940

caggctatac cattcagaag gctgacaaga agagcatgga atggtttact gtcattgagc     3000

attatcatcg aaccagtgcc accattactg aattggtcat agggaatgaa tattacttcc     3060

gggtcttttc tgaaaacatg tgtggcctca gtgaggatgc caccatgact aaagagagtg     3120

cagtgatcgc cagggatggt aaaatctaca aaaatccagt gtatgaagac tttgatttct     3180

cagaggcacc catgtttact cagcctttgg ttaacaccta tgccatagct ggttacaatg     3240

ccaccctaaa ctgcagtgtg agaggaaatc ctaagcctaa aataacctgg atgaaaaaca     3300

aagttgctat tgtggatgat ccaagataca ggatgttcag caaccaggga gtctgtaccc     3360

tggaaattcg caagcccagc ccctatgatg gaggcactta ctgctgcaaa gcagtcaatg     3420

accttgggac agtggagatt gaatgcaaac tggaggtgaa agtgatatat caaggagtaa     3480

atacccctgg acaaccagtc ttcctggagg ggcagcaaca gtcattgcac aataaggatt     3540

tttgaatgta taatatcatc taaggtgggc tctccttctg cagactcctc ttgcaaggcg     3600

tacctccaaa cataattgat tcgtatctgc gagacttaca ctcaagcaat cctgaggaat     3660

actgagggag ggcctggcta ctgtctctct gcactctgct gctttgaaat ctggttgaaa     3720

tgagaaaaag cattttctgt tttcccacca ggcccccaag tgtggtcttt ttctttcctc     3780

ctaatgttga agagaaaaaa aaaaaaaaaa gtttgcccag attgcttaat taaaaattgc     3840

aaacaaaatc tcatttgaag tcaaaaaaaa aaaaaaaaaa aaa                       3883


<210>  67
<211>  3862
<212>  DNA
<213>  Homo sapiens

<400>  67
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagactggac ccttgtcgaa actcctcctg gggaggaaca agccaagcag aatgccaact      300

cccagctgtc catcttgttc attgaaaaac ctcaaggagg aacagtgaaa gttggtgaag      360

atatcacctt catagccaaa gtcaaggctg aagatcttct gagaaaaccc actatcaaat      420

ggttcaaagg aaaatggatg gacctggcca gcaaagccgg gaagcacctt cagctgaagg      480

aaacctttga gaggcacagt cgggtgtaca catttgagat gcagatcatc aaggccaaag      540

ataactttgc aggaaattac agatgcgagg tcacctataa ggataagttt gacagctgtt      600

catttgatct tgaagtgcac gaatctactg ggactactcc aaacattgac atcagatctg      660

ctttcaagag aagggaggtg aagcagcagg aggaagaacc ccaggtggac gtatgggagt      720

tgctgaagaa cgcgaaaccc agtgagtacg agaagatcgc cttccagtat ggaatcaccg      780

acctgcgcgg catgctcaag cgactcaagc gcatgcgcag agaggagaag aagagcgcag      840

cttttgcaaa aattcttgat cctgcatatc aggttgacaa aggaggcaga gtgaggtttg      900

ttgtggagct ggcagatcca aagttggagg tgaaatggta taaaaatggt caagaaattc      960

gacccagtac caaatacatc tttgaacaca aaggatgcca gagaatcctg tttatcaata     1020

actgtcagat gacagatgat tcagagtatt atgtgacagc cggtgatgag aaatgttcca     1080

ctgagctctt cgtaagagag cctccaatta tggtgaccaa acagctggaa gatacaactg     1140

cttattgtgg ggagagagtg gaattagaat gtgaggtgtc tgaagatgat gccaatgtaa     1200

aatggtttaa gaatggtgaa gagattatcc ctggtccaaa atcaagatac cgaattagag     1260

ttgagggtaa aaaacacatc ttgatcatag agggagcaac aaaggctgat gctgcagaat     1320

attcagtaat gacaacagga ggacaatcat ctgctaaact tagtgttgac ttgaaacctc     1380

tgaagatttt gacacctctg actgatcaga ctgtaaatct tggaaaagaa atctgcctga     1440

agtgtgaaat ctctgaaaac ataccaggaa aatggactaa aaatggccta cctgttcagg     1500

agagtgaccg tctaaaggtg gttcacaagg gaaggatcca caagttagtg atagccaatg     1560

ccctcactga agatgaaggt gattatgtat ttgcacctga tgcctacaat gttactctgc     1620

ctgccaaagt tcatgttatt gatcctccta agatcatcct ggatggtctt gatgctgaca     1680

acacagtgac agtgattgca ggaaacaagc ttcgtcttga gatccccatc agcggagaac     1740

cacctcctaa agccatgtgg agccggggag ataaggctat tatggaaggc agtggccgga     1800

taagaacaga atcttaccct gatagcagca ctctggtcat tgatatagct gaaagagatg     1860

actctggtgt ttaccacatc aatctgaaaa acgaagctgg agaggcacat gcaagcatca     1920

aggttaaagt tgtggacttc cctgatcctc cagtggcacc gactgtgaca gaggtgggag     1980

atgactggtg tatcatgaac tgggagcctc ctgcctacga cggaggctct ccaatcctag     2040

gatattttat tgagaggaag aagaaacaaa gctccaggtg gatgaggctg aattttgatc     2100

tctgcaaaga aacaactttt gagcccaaga agatgattga aggtgtggcc tatgaggtcc     2160

gcatctttgc agtcaatgcc attggcatct ccaagcccag tatgccctcc aggccttttg     2220

ttcctttggc tgtaacaagc cctcctactc ttctgactgt ggactctgtc actgacacga     2280

ctgtcacgat gaggtggcgc cccccagacc acattggtgc agcaggttta gatggctatg     2340

tgctagagta ttgctttgaa ggaactgagg actggatagt tgcaaacaaa gatctgattg     2400

acaagacgaa gttcaccatc acaggtctgc caacagatgc aaagatcttt gtgcgtgtga     2460

aggctgttaa tgcagctggt gccagcgagc ccaagtacta ttctcagccc attctcgtga     2520

aggaaatcat agaacctcca aagattcgca ttccaagaca cctgaagcaa acctatatcc     2580

gcagagttgg agaagctgtc aatctggtta tacctttcca gggaaaacca agaccagaat     2640

taacttggaa gaaggatggt gcagaaattg ataagaatca aataaacatt cgcaactctg     2700

agactgatac aatcatattt attagaaaag cagagaggag ccactctggg aaatatgatc     2760

tgcaagtcaa agtggacaaa ttcgtggaga ccgcatcaat tgacatccag atcattgacc     2820

gtccaggtcc accccaaatt gtgaagattg aggatgtctg gggagaaaat gtcgctctca     2880

catggactcc accaaaggat gatggaaatg ctgctatcac aggctatacc attcagaagg     2940

ctgacaagaa gagcatggaa tggtttactg tcattgagca ttatcatcga accagtgcca     3000

ccattactga attggtcata gggaatgaat attacttccg ggtcttttct gaaaacatgt     3060

gtggcctcag tgaggatgcc accatgacta aagagagtgc agtgatcgcc agggatggta     3120

aaatctacaa aaatccagtg tatgaagact ttgatttctc agaggcaccc atgtttactc     3180

agcctttggt taacacctat gccatagctg gttacaatgc caccctaaac tgcagtgtga     3240

gaggaaatcc taagcctaaa ataacctgga tgaaaaacaa agttgctatt gtggatgatc     3300

caagatacag gatgttcagc aaccagggag tctgtaccct ggaaattcgc aagcccagcc     3360

cctatgatgg aggcacttac tgctgcaaag cagtcaatga ccttgggaca gtggagattg     3420

aatgcaaact ggaggtgaaa gtgatatatc aaggagtaaa tacccctgga caaccagtct     3480

tcctggaggg gcagcaacag tcattgcaca ataaggattt ttgaatgtat aatatcatct     3540

aaggtgggct ctccttctgc agactcctct tgcaaggcgt acctccaaac ataattgatt     3600

cgtatctgcg agacttacac tcaagcaatc ctgaggaata ctgagggagg gcctggctac     3660

tgtctctctg cactctgctg ctttgaaatc tggttgaaat gagaaaaagc attttctgtt     3720

ttcccaccag gcccccaagt gtggtctttt tctttcctcc taatgttgaa gagaaaaaaa     3780

aaaaaaaaag tttgcccaga ttgcttaatt aaaaattgca aacaaaatct catttgaagt     3840

caaaaaaaaa aaaaaaaaaa aa                                              3862


<210>  68
<211>  3841
<212>  DNA
<213>  Homo sapiens

<400>  68
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggactgg acccttgtcg      180

aaactcctcc tggggaggaa caagccaagc agaatgccaa ctcccagctg tccatcttgt      240

tcattgaaaa acctcaagga ggaacagtga aagttggtga agatatcacc ttcatagcca      300

aagtcaaggc tgaagatctt ctgagaaaac ccactatcaa atggttcaaa ggaaaatgga      360

tggacctggc cagcaaagcc gggaagcacc ttcagctgaa ggaaaccttt gagaggcaca      420

gtcgggtgta cacatttgag atgcagatca tcaaggccaa agataacttt gcaggaaatt      480

acagatgcga ggtcacctat aaggataagt ttgacagctg ttcatttgat cttgaagtgc      540

acgaatctac tgggactact ccaaacattg acatcagatc tgctttcaag agaagtggag      600

aaggtcaaga ggatgcagga gaacttgact ttagtggtct cctgaaacgt agggaggtga      660

agcagcagga ggaagaaccc caggtggacg tatgggagtt gctgaagaac gcgaaaccca      720

gtgagtacga gaagatcgcc ttccagtatg gaatcaccga cctgcgcggc atgctcaagc      780

gactcaagcg catgcgcaga gaggagaaga agagcgcagc ttttgcaaaa attcttgatc      840

ctgcatatca ggttgacaaa ggaggcagag tgaggtttgt tgtggagctg gcagatccaa      900

agttggaggt gaaatggtat aaaaatggtc aagaaattcg acccagtacc aaatacatct      960

ttgaacacaa aggatgccag agaatcctgt ttatcaataa ctgtcagatg acagatgatt     1020

cagagtatta tgtgacagcc ggtgatgaga aatgttccac tgagctcttc gtaagagagc     1080

ctccaattat ggtgaccaaa cagctggaag atacaactgc ttattgtggg gagagagtgg     1140

aattagaatg tgaggtgtct gaagatgatg ccaatgtaaa atggtttaag aatggtgaag     1200

agattatccc tggtccaaaa tcaagatacc gaattagagt tgagggtaaa aaacacatct     1260

tgatcataga gggagcaaca aaggctgatg ctgcagaata ttcagtaatg acaacaggag     1320

gacaatcatc tgctaaactt agtgttgact tgaaacctct gaagattttg acacctctga     1380

ctgatcagac tgtaaatctt ggaaaagaaa tctgcctgaa gtgtgaaatc tctgaaaaca     1440

taccaggaaa atggactaaa aatggcctac ctgttcagga gagtgaccgt ctaaaggtgg     1500

ttcacaaggg aaggatccac aagttagtga tagccaatgc cctcactgaa gatgaaggtg     1560

attatgtatt tgcacctgat gcctacaatg ttactctgcc tgccaaagtt catgttattg     1620

atcctcctaa gatcatcctg gatggtcttg atgctgacaa cacagtgaca gtgattgcag     1680

gaaacaagct tcgtcttgag atccccatca gcggagaacc acctcctaaa gccatgtgga     1740

gccggggaga taaggctatt atggaaggca gtggccggat aagaacagaa tcttaccctg     1800

atagcagcac tctggtcatt gatatagctg aaagagatga ctctggtgtt taccacatca     1860

atctgaaaaa cgaagctgga gaggcacatg caagcatcaa ggttaaagtt gtggacttcc     1920

ctgatcctcc agtggcaccg actgtgacag aggtgggaga tgactggtgt atcatgaact     1980

gggagcctcc tgcctacgac ggaggctctc caatcctagg atattttatt gagaggaaga     2040

agaaacaaag ctccaggtgg atgaggctga attttgatct ctgcaaagaa acaacttttg     2100

agcccaagaa gatgattgaa ggtgtggcct atgaggtccg catctttgca gtcaatgcca     2160

ttggcatctc caagcccagt atgccctcca ggccttttgt tcctttggct gtaacaagcc     2220

ctcctactct tctgactgtg gactctgtca ctgacacgac tgtcacgatg aggtggcgcc     2280

ccccagacca cattggtgca gcaggtttag atggctatgt gctagagtat tgctttgaag     2340

gaactgagga ctggatagtt gcaaacaaag atctgattga caagacgaag ttcaccatca     2400

caggtctgcc aacagatgca aagatctttg tgcgtgtgaa ggctgttaat gcagctggtg     2460

ccagcgagcc caagtactat tctcagccca ttctcgtgaa ggaaatcata gaacctccaa     2520

agattcgcat tccaagacac ctgaagcaaa cctatatccg cagagttgga gaagctgtca     2580

atctggttat acctttccag ggaaaaccaa gaccagaatt aacttggaag aaggatggtg     2640

cagaaattga taagaatcaa ataaacattc gcaactctga gactgataca atcatattta     2700

ttagaaaagc agagaggagc cactctggga aatatgatct gcaagtcaaa gtggacaaat     2760

tcgtggagac cgcatcaatt gacatccaga tcattgaccg tccaggtcca ccccaaattg     2820

tgaagattga ggatgtctgg ggagaaaatg tcgctctcac atggactcca ccaaaggatg     2880

atggaaatgc tgctatcaca ggctatacca ttcagaaggc tgacaagaag agcatggaat     2940

ggtttactgt cattgagcat tatcatcgaa ccagtgccac cattactgaa ttggtcatag     3000

ggaatgaata ttacttccgg gtcttttctg aaaacatgtg tggcctcagt gaggatgcca     3060

ccatgactaa agagagtgca gtgatcgcca gggatggtaa aatctacaaa aatccagtgt     3120

atgaagactt tgatttctca gaggcaccca tgtttactca gcctttggtt aacacctatg     3180

ccatagctgg ttacaatgcc accctaaact gcagtgtgag aggaaatcct aagcctaaaa     3240

taacctggat gaaaaacaaa gttgctattg tggatgatcc aagatacagg atgttcagca     3300

accagggagt ctgtaccctg gaaattcgca agcccagccc ctatgatgga ggcacttact     3360

gctgcaaagc agtcaatgac cttgggacag tggagattga atgcaaactg gaggtgaaag     3420

tgatatatca aggagtaaat acccctggac aaccagtctt cctggagggg cagcaacagt     3480

cattgcacaa taaggatttt tgaatgtata atatcatcta aggtgggctc tccttctgca     3540

gactcctctt gcaaggcgta cctccaaaca taattgattc gtatctgcga gacttacact     3600

caagcaatcc tgaggaatac tgagggaggg cctggctact gtctctctgc actctgctgc     3660

tttgaaatct ggttgaaatg agaaaaagca ttttctgttt tcccaccagg cccccaagtg     3720

tggtcttttt ctttcctcct aatgttgaag agaaaaaaaa aaaaaaaagt ttgcccagat     3780

tgcttaatta aaaattgcaa acaaaatctc atttgaagtc aaaaaaaaaa aaaaaaaaaa     3840

a                                                                     3841


<210>  69
<211>  3778
<212>  DNA
<213>  Homo sapiens

<400>  69
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggatgaa gaggaagtct      180

ccccgcctag cgccttgcct ccagactgga cccttgtcga aactcctcct ggggaggaac      240

aagccaagca gaatgccaac tcccagctgt ccatcttgtt cattgaaaaa cctcaaggag      300

gaacagtgaa agttggtgaa gatatcacct tcatagccaa agtcaaggct gaagatcttc      360

tgagaaaacc cactatcaaa tggttcaaag gaaaatggat ggacctggcc agcaaagccg      420

ggaagcacct tcagctgaag gaaacctttg agaggcacag tcgggtgtac acatttgaga      480

tgcagatcat caaggccaaa gataactttg caggaaatta cagatgcgag gtcacctata      540

aggataagtt tgacagctgt tcatttgatc ttgaagtgca cgaatctact gggactactc      600

caaacattga catcagatct gctttcaaga gaagtggaga aggtcaagag gatgcaggag      660

aacttgactt tagtggtctc ctgaaacgta gggaggtgaa gcagcaggag gaagaacccc      720

aggtggacgt atgggagttg ctgaagaacg cgaaacccag tgagtacgag aagatcgcct      780

tccagtatgg aatcaccgac ctgcgcggca tgctcaagcg actcaagcgc atgcgcagag      840

aggagaagaa gagcgcagct tttgcaaaaa ttcttgatcc tgcatatcag gttgacaaag      900

gaggcagagt gaggtttgtt gtggagctgg cagatccaaa gttggaggtg aaatggtata      960

aaaatggtca agaaattcga cccagtacca aatacatctt tgaacacaaa ggatgccaga     1020

gaatcctgtt tatcaataac tgtcagatga cagatgattc agagtattat gtgacagccg     1080

gtgatgagaa atgttccact gagctcttcg taagagagcc tccaattatg gtgaccaaac     1140

agctggaaga tacaactgct tattgtgggg agagagtgga attagaatgt gaggtgtctg     1200

aagatgatgc caatgtaaaa tggtttaaga atggtgaaga gattatccct ggtccaaaat     1260

caagataccg aattagagtt gagggtaaaa aacacatctt gatcatagag ggagcaacaa     1320

aggctgatgc tgcagaatat tcagtaatga caacaggagg acaatcatct gctaaactta     1380

gtgttgactt gaaacctctg aagattttga cacctctgac tgatcagact gtaaatcttg     1440

gaaaagaaat ctgcctgaag tgtgaaatct ctgaaaacat accaggaaaa tggactaaaa     1500

atggcctacc tgttcaggag agtgaccgtc taaaggtggt tcacaaggga aggatccaca     1560

agttagtgat agccaatgcc ctcactgaag atgaaggtga ttatgtattt gcacctgatg     1620

cctacaatgt tactctgcct gccaaagttc atgttattga tcctcctaag atcatcctgg     1680

atggtcttga tgctgacaac acagtgacag tgattgcagg aaacaagctt cgtcttgaga     1740

tccccatcag cggagaacca cctcctaaag ccatgtggag ccggggagat aaggctatta     1800

tggaaggcag tggccggata agaacagaat cttaccctga tagcagcact ctggtcattg     1860

atatagctga aagagatgac tctggtgttt accacatcaa tctgaaaaac gaagctggag     1920

aggcacatgc aagcatcaag gttaaagttg tggacttccc tgatcctcca gtggcaccga     1980

ctgtgacaga ggtgggagat gactggtgta tcatgaactg ggagcctcct gcctacgacg     2040

gaggctctcc aatcctagga tattttattg agaggaagaa gaaacaaagc tccaggtgga     2100

tgaggctgaa ttttgatctc tgcaaagaaa caacttttga gcccaagaag atgattgaag     2160

gtgtggccta tgaggtccgc atctttgcag tcaatgccat tggcatctcc aagcccagta     2220

tgccctccag gccttttgtt cctttggctg taacaagccc tcctactctt ctgactgtgg     2280

actctgtcac tgacacgact gtcacgatga ggtggcgccc cccagaccac attggtgcag     2340

caggtttaga tggctatgtg ctagagtatt gctttgaagg aactgaggac tggatagttg     2400

caaacaaaga tctgattgac aagacgaagt tcaccatcac aggtctgcca acagatgcaa     2460

agatctttgt gcgtgtgaag gctgttaatg cagctggtgc cagcgagccc aagtactatt     2520

ctcagcccat tctcgtgaag gaaatcatag aacctccaaa gattcgcatt ccaagacacc     2580

tgaagcaaac ctatatccgc agagttggag aagctgtcaa tctggttata cctttccagg     2640

gaaaaccaag accagaatta acttggaaga aggatggtgc agaaattgat aagaatcaaa     2700

taaacattcg caactctgag actgatacaa tcatatttat tagaaaagca gagaggagcc     2760

actctgggaa atatgatctg caagtcaaag tggacaaatt cgtggagacc gcatcaattg     2820

acatccagat cattgaccgt ccaggtccac cccaaattgt gaagattgag gatgtctggg     2880

gagaaaatgt cgctctcaca tggactccac caaaggatga tggaaatgct gctatcacag     2940

gctataccat tcagaaggct gacaagaaga gcatggaatg gtttactgtc attgagcatt     3000

atcatcgaac cagtgccacc attactgaat tggtcatagg gaatgaatat tacttccggg     3060

tcttttctga aaacatgtgt ggcctcagtg aggatgccac catgactaaa gagagtgcag     3120

tgatcgccag ggatggtaaa atctacaaaa atccagtgta tgaagacttt gatttctcag     3180

aggcacccat gtttactcag cctttggtta acacctatgc catagctggt tacaatgcca     3240

ccctaaactg cagtgtgaga ggaaatccta agcctaaaat aacctggatg aaaaacaaag     3300

ttgctattgt ggatgatcca agatacagga tgttcagcaa ccagggagtc tgtaccctgg     3360

aaattcgcaa gcccagcccc tatgatggag gcacttactg ctgcaaagca gtcaatgacc     3420

ttgggacagt ggagattgaa tgcaaactgg aggtgaaagg tgggctctcc ttctgcagac     3480

tcctcttgca aggcgtacct ccaaacataa ttgattcgta tctgcgagac ttacactcaa     3540

gcaatcctga ggaatactga gggagggcct ggctactgtc tctctgcact ctgctgcttt     3600

gaaatctggt tgaaatgaga aaaagcattt tctgttttcc caccaggccc ccaagtgtgg     3660

tctttttctt tcctcctaat gttgaagaga aaaaaaaaaa aaaaagtttg cccagattgc     3720

ttaattaaaa attgcaaaca aaatctcatt tgaagtcaaa aaaaaaaaaa aaaaaaaa       3778


<210>  70
<211>  3994
<212>  DNA
<213>  Homo sapiens

<400>  70
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagatgaaga ggaagtctcc ccgcctagcg ccttgcctcc aggtttgggt agtcgggccc      300

tggagagaaa agattcagac tggacccttg tcgaaactcc tcctggggag gaacaagcca      360

agcagaatgc caactcccag ctgtccatct tgttcattga aaaacctcaa ggaggaacag      420

tgaaagttgg tgaagatatc accttcatag ccaaagtcaa ggctgaagat cttctgagaa      480

aacccactat caaatggttc aaaggaaaat ggatggacct ggccagcaaa gccgggaagc      540

accttcagct gaaggaaacc tttgagaggc acagtcgggt gtacacattt gagatgcaga      600

tcatcaaggc caaagataac tttgcaggaa attacagatg cgaggtcacc tataaggata      660

agtttgacag ctgttcattt gatcttgaag tgcacgaatc tactgggact actccaaaca      720

ttgacatcag atctgctttc aagagaagtg gagaaggtca agaggatgca ggagaacttg      780

actttagtgg tctcctgaaa cgtagggagg tgaagcagca ggaggaagaa ccccaggtgg      840

acgtatggga gttgctgaag aacgcgaaac ccagtgagta cgagaagatc gccttccagt      900

atggaatcac cgacctgcgc ggcatgctca agcgactcaa gcgcatgcgc agagaggaga      960

agaagagcgc agcttttgca aaaattcttg atcctgcata tcaggttgac aaaggaggca     1020

gagtgaggtt tgttgtggag ctggcagatc caaagttgga ggtgaaatgg tataaaaatg     1080

gtcaagaaat tcgacccagt accaaataca tctttgaaca caaaggatgc cagagaatcc     1140

tgtttatcaa taactgtcag atgacagatg attcagagta ttatgtgaca gccggtgatg     1200

agaaatgttc cactgagctc ttcgtaagag agcctccaat tatggtgacc aaacagctgg     1260

aagatacaac tgcttattgt ggggagagag tggaattaga atgtgaggtg tctgaagatg     1320

atgccaatgt aaaatggttt aagaatggtg aagagattat ccctggtcca aaatcaagat     1380

accgaattag agttgagggt aaaaaacaca tcttgatcat agagggagca acaaaggctg     1440

atgctgcaga atattcagta atgacaacag gaggacaatc atctgctaaa cttagtgttg     1500

acttgaaacc tctgaagatt ttgacacctc tgactgatca gactgtaaat cttggaaaag     1560

aaatctgcct gaagtgtgaa atctctgaaa acataccagg aaaatggact aaaaatggcc     1620

tacctgttca ggagagtgac cgtctaaagg tggttcacaa gggaaggatc cacaagttag     1680

tgatagccaa tgccctcact gaagatgaag gtgattatgt atttgcacct gatgcctaca     1740

atgttactct gcctgccaaa gttcatgtta ttgatcctcc taagatcatc ctggatggtc     1800

ttgatgctga caacacagtg acagtgattg caggaaacaa gcttcgtctt gagatcccca     1860

tcagcggaga accacctcct aaagccatgt ggagccgggg agataaggct attatggaag     1920

gcagtggccg gataagaaca gaatcttacc ctgatagcag cactctggtc attgatatag     1980

ctgaaagaga tgactctggt gtttaccaca tcaatctgaa aaacgaagct ggagaggcac     2040

atgcaagcat caaggttaaa gttgtggact tccctgatcc tccagtggca ccgactgtga     2100

cagaggtggg agatgactgg tgtatcatga actgggagcc tcctgcctac gacggaggct     2160

ctccaatcct aggatatttt attgagagga agaagaaaca aagctccagg tggatgaggc     2220

tgaattttga tctctgcaaa gaaacaactt ttgagcccaa gaagatgatt gaaggtgtgg     2280

cctatgaggt ccgcatcttt gcagtcaatg ccattggcat ctccaagccc agtatgccct     2340

ccaggccttt tgttcctttg gctgtaacaa gccctcctac tcttctgact gtggactctg     2400

tcactgacac gactgtcacg atgaggtggc gccccccaga ccacattggt gcagcaggtt     2460

tagatggcta tgtgctagag tattgctttg aaggaactga ggactggata gttgcaaaca     2520

aagatctgat tgacaagacg aagttcacca tcacaggtct gccaacagat gcaaagatct     2580

ttgtgcgtgt gaaggctgtt aatgcagctg gtgccagcga gcccaagtac tattctcagc     2640

ccattctcgt gaaggaaatc atagaacctc caaagattcg cattccaaga cacctgaagc     2700

aaacctatat ccgcagagtt ggagaagctg tcaatctggt tatacctttc cagggaaaac     2760

caagaccaga attaacttgg aagaaggatg gtgcagaaat tgataagaat caaataaaca     2820

ttcgcaactc tgagactgat acaatcatat ttattagaaa agcagagagg agccactctg     2880

ggaaatatga tctgcaagtc aaagtggaca aattcgtgga gaccgcatca attgacatcc     2940

agatcattga ccgtccaggt ccaccccaaa ttgtgaagat tgaggatgtc tggggagaaa     3000

atgtcgctct cacatggact ccaccaaagg atgatggaaa tgctgctatc acaggctata     3060

ccattcagaa ggctgacaag aagagcatgg aatggtttac tgtcattgag cattatcatc     3120

gaaccagtgc caccattact gaattggtca tagggaatga atattacttc cgggtctttt     3180

ctgaaaacat gtgtggcctc agtgaggatg ccaccatgac taaagagagt gcagtgatcg     3240

ccagggatgg taaaatctac aaaaatccag tgtatgaaga ctttgatttc tcagaggcac     3300

ccatgtttac tcagcctttg gttaacacct atgccatagc tggttacaat gccaccctaa     3360

actgcagtgt gagaggaaat cctaagccta aaataacctg gatgaaaaac aaagttgcta     3420

ttgtggatga tccaagatac aggatgttca gcaaccaggg agtctgtacc ctggaaattc     3480

gcaagcccag cccctatgat ggaggcactt actgctgcaa agcagtcaat gaccttggga     3540

cagtggagat tgaatgcaaa ctggaggtga aagtgatata tcaaggagta aatacccctg     3600

gacaaccagt cttcctggag gggcagcaac agtcattgca caataaggat ttttgaatgt     3660

ataatatcat ctaaggtggg ctctccttct gcagactcct cttgcaaggc gtacctccaa     3720

acataattga ttcgtatctg cgagacttac actcaagcaa tcctgaggaa tactgaggga     3780

gggcctggct actgtctctc tgcactctgc tgctttgaaa tctggttgaa atgagaaaaa     3840

gcattttctg ttttcccacc aggcccccaa gtgtggtctt tttctttcct cctaatgttg     3900

aagagaaaaa aaaaaaaaaa agtttgccca gattgcttaa ttaaaaattg caaacaaaat     3960

ctcatttgaa gtcaaaaaaa aaaaaaaaaa aaaa                                 3994


<210>  71
<211>  3935
<212>  DNA
<213>  Homo sapiens

<400>  71
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagatgaaga ggaagtctcc ccgcctagcg ccttgcctcc aggtttgggt agtcgggccc      300

tggagagaaa agattcagac tggacccttg tcgaaactcc tcctggggag gaacaagcca      360

agcagaatgc caactcccag ctgtccatct tgttcattga aaaacctcaa ggaggaacag      420

tgaaagttgg tgaagatatc accttcatag ccaaagtcaa ggctgaagat cttctgagaa      480

aacccactat caaatggttc aaaggaaaat ggatggacct ggccagcaaa gccgggaagc      540

accttcagct gaaggaaacc tttgagaggc acagtcgggt gtacacattt gagatgcaga      600

tcatcaaggc caaagataac tttgcaggaa attacagatg cgaggtcacc tataaggata      660

agtttgacag ctgttcattt gatcttgaag tgcacgaatc tactgggact actccaaaca      720

ttgacatcag atctgctttc aagagaagtg gagaaggtca agaggatgca ggagaacttg      780

actttagtgg tctcctgaaa cgtagggagg tgaagcagca ggaggaagaa ccccaggtgg      840

acgtatggga gttgctgaag aacgcgaaac ccagtgagta cgagaagatc gccttccagt      900

atggaatcac cgacctgcgc ggcatgctca agcgactcaa gcgcatgcgc agagaggaga      960

agaagagcgc agcttttgca aaaattcttg atcctgcata tcaggttgac aaaggaggca     1020

gagtgaggtt tgttgtggag ctggcagatc caaagttgga ggtgaaatgg tataaaaatg     1080

gtcaagaaat tcgacccagt accaaataca tctttgaaca caaaggatgc cagagaatcc     1140

tgtttatcaa taactgtcag atgacagatg attcagagta ttatgtgaca gccggtgatg     1200

agaaatgttc cactgagctc ttcgtaagag agcctccaat tatggtgacc aaacagctgg     1260

aagatacaac tgcttattgt ggggagagag tggaattaga atgtgaggtg tctgaagatg     1320

atgccaatgt aaaatggttt aagaatggtg aagagattat ccctggtcca aaatcaagat     1380

accgaattag agttgagggt aaaaaacaca tcttgatcat agagggagca acaaaggctg     1440

atgctgcaga atattcagta atgacaacag gaggacaatc atctgctaaa cttagtgttg     1500

acttgaaacc tctgaagatt ttgacacctc tgactgatca gactgtaaat cttggaaaag     1560

aaatctgcct gaagtgtgaa atctctgaaa acataccagg aaaatggact aaaaatggcc     1620

tacctgttca ggagagtgac cgtctaaagg tggttcacaa gggaaggatc cacaagttag     1680

tgatagccaa tgccctcact gaagatgaag gtgattatgt atttgcacct gatgcctaca     1740

atgttactct gcctgccaaa gttcatgtta ttgatcctcc taagatcatc ctggatggtc     1800

ttgatgctga caacacagtg acagtgattg caggaaacaa gcttcgtctt gagatcccca     1860

tcagcggaga accacctcct aaagccatgt ggagccgggg agataaggct attatggaag     1920

gcagtggccg gataagaaca gaatcttacc ctgatagcag cactctggtc attgatatag     1980

ctgaaagaga tgactctggt gtttaccaca tcaatctgaa aaacgaagct ggagaggcac     2040

atgcaagcat caaggttaaa gttgtggact tccctgatcc tccagtggca ccgactgtga     2100

cagaggtggg agatgactgg tgtatcatga actgggagcc tcctgcctac gacggaggct     2160

ctccaatcct aggatatttt attgagagga agaagaaaca aagctccagg tggatgaggc     2220

tgaattttga tctctgcaaa gaaacaactt ttgagcccaa gaagatgatt gaaggtgtgg     2280

cctatgaggt ccgcatcttt gcagtcaatg ccattggcat ctccaagccc agtatgccct     2340

ccaggccttt tgttcctttg gctgtaacaa gccctcctac tcttctgact gtggactctg     2400

tcactgacac gactgtcacg atgaggtggc gccccccaga ccacattggt gcagcaggtt     2460

tagatggcta tgtgctagag tattgctttg aaggaactga ggactggata gttgcaaaca     2520

aagatctgat tgacaagacg aagttcacca tcacaggtct gccaacagat gcaaagatct     2580

ttgtgcgtgt gaaggctgtt aatgcagctg gtgccagcga gcccaagtac tattctcagc     2640

ccattctcgt gaaggaaatc atagaacctc caaagattcg cattccaaga cacctgaagc     2700

aaacctatat ccgcagagtt ggagaagctg tcaatctggt tatacctttc cagggaaaac     2760

caagaccaga attaacttgg aagaaggatg gtgcagaaat tgataagaat caaataaaca     2820

ttcgcaactc tgagactgat acaatcatat ttattagaaa agcagagagg agccactctg     2880

ggaaatatga tctgcaagtc aaagtggaca aattcgtgga gaccgcatca attgacatcc     2940

agatcattga ccgtccaggt ccaccccaaa ttgtgaagat tgaggatgtc tggggagaaa     3000

atgtcgctct cacatggact ccaccaaagg atgatggaaa tgctgctatc acaggctata     3060

ccattcagaa ggctgacaag aagagcatgg aatggtttac tgtcattgag cattatcatc     3120

gaaccagtgc caccattact gaattggtca tagggaatga atattacttc cgggtctttt     3180

ctgaaaacat gtgtggcctc agtgaggatg ccaccatgac taaagagagt gcagtgatcg     3240

ccagggatgg taaaatctac aaaaatccag tgtatgaaga ctttgatttc tcagaggcac     3300

ccatgtttac tcagcctttg gttaacacct atgccatagc tggttacaat gccaccctaa     3360

actgcagtgt gagaggaaat cctaagccta aaataacctg gatgaaaaac aaagttgcta     3420

ttgtggatga tccaagatac aggatgttca gcaaccaggg agtctgtacc ctggaaattc     3480

gcaagcccag cccctatgat ggaggcactt actgctgcaa agcagtcaat gaccttggga     3540

cagtggagat tgaatgcaaa ctggaggtga aagtcattgc acaataagga tttttgaatg     3600

tataatatca tctaaggtgg gctctccttc tgcagactcc tcttgcaagg cgtacctcca     3660

aacataattg attcgtatct gcgagactta cactcaagca atcctgagga atactgaggg     3720

agggcctggc tactgtctct ctgcactctg ctgctttgaa atctggttga aatgagaaaa     3780

agcattttct gttttcccac caggccccca agtgtggtct ttttctttcc tcctaatgtt     3840

gaagagaaaa aaaaaaaaaa aagtttgccc agattgctta attaaaaatt gcaaacaaaa     3900

tctcatttga agtcaaaaaa aaaaaaaaaa aaaaa                                3935


<210>  72
<211>  3914
<212>  DNA
<213>  Homo sapiens

<400>  72
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagactggac ccttgtcgaa actcctcctg gggaggaaca agccaagcag aatgccaact      300

cccagctgtc catcttgttc attgaaaaac ctcaaggagg aacagtgaaa gttggtgaag      360

atatcacctt catagccaaa gtcaaggctg aagatcttct gagaaaaccc actatcaaat      420

ggttcaaagg aaaatggatg gacctggcca gcaaagccgg gaagcacctt cagctgaagg      480

aaacctttga gaggcacagt cgggtgtaca catttgagat gcagatcatc aaggccaaag      540

ataactttgc aggaaattac agatgcgagg tcacctataa ggataagttt gacagctgtt      600

catttgatct tgaagtgcac gaatctactg ggactactcc aaacattgac atcagatctg      660

ctttcaagag aagtggagaa ggtcaagagg atgcaggaga acttgacttt agtggtctcc      720

tgaaacgtag ggaggtgaag cagcaggagg aagaacccca ggtggacgta tgggagttgc      780

tgaagaacgc gaaacccagt gagtacgaga agatcgcctt ccagtatgga atcaccgacc      840

tgcgcggcat gctcaagcga ctcaagcgca tgcgcagaga ggagaagaag agcgcagctt      900

ttgcaaaaat tcttgatcct gcatatcagg ttgacaaagg aggcagagtg aggtttgttg      960

tggagctggc agatccaaag ttggaggtga aatggtataa aaatggtcaa gaaattcgac     1020

ccagtaccaa atacatcttt gaacacaaag gatgccagag aatcctgttt atcaataact     1080

gtcagatgac agatgattca gagtattatg tgacagccgg tgatgagaaa tgttccactg     1140

agctcttcgt aagagagcct ccaattatgg tgaccaaaca gctggaagat acaactgctt     1200

attgtgggga gagagtggaa ttagaatgtg aggtgtctga agatgatgcc aatgtaaaat     1260

ggtttaagaa tggtgaagag attatccctg gtccaaaatc aagataccga attagagttg     1320

agggtaaaaa acacatcttg atcatagagg gagcaacaaa ggctgatgct gcagaatatt     1380

cagtaatgac aacaggagga caatcatctg ctaaacttag tgttgacttg aaacctctga     1440

agattttgac acctctgact gatcagactg taaatcttgg aaaagaaatc tgcctgaagt     1500

gtgaaatctc tgaaaacata ccaggaaaat ggactaaaaa tggcctacct gttcaggaga     1560

gtgaccgtct aaaggtggtt cacaagggaa ggatccacaa gttagtgata gccaatgccc     1620

tcactgaaga tgaaggtgat tatgtatttg cacctgatgc ctacaatgtt actctgcctg     1680

ccaaagttca tgttattgat cctcctaaga tcatcctgga tggtcttgat gctgacaaca     1740

cagtgacagt gattgcagga aacaagcttc gtcttgagat ccccatcagc ggagaaccac     1800

ctcctaaagc catgtggagc cggggagata aggctattat ggaaggcagt ggccggataa     1860

gaacagaatc ttaccctgat agcagcactc tggtcattga tatagctgaa agagatgact     1920

ctggtgttta ccacatcaat ctgaaaaacg aagctggaga ggcacatgca agcatcaagg     1980

ttaaagttgt ggacttccct gatcctccag tggcaccgac tgtgacagag gtgggagatg     2040

actggtgtat catgaactgg gagcctcctg cctacgacgg aggctctcca atcctaggat     2100

attttattga gaggaagaag aaacaaagct ccaggtggat gaggctgaat tttgatctct     2160

gcaaagaaac aacttttgag cccaagaaga tgattgaagg tgtggcctat gaggtccgca     2220

tctttgcagt caatgccatt ggcatctcca agcccagtat gccctccagg ccttttgttc     2280

ctttggctgt aacaagccct cctactcttc tgactgtgga ctctgtcact gacacgactg     2340

tcacgatgag gtggcgcccc ccagaccaca ttggtgcagc aggtttagat ggctatgtgc     2400

tagagtattg ctttgaagga agtacatcag caaaacagtc tgatgaaaat ggggaggctg     2460

cctatgatct gccagctgag gactggatag ttgcaaacaa agatctgatt gacaagacga     2520

agttcaccat cacaggtctg ccaacagatg caaagatctt tgtgcgtgtg aaggctgtta     2580

atgcagctgg tgccagcgag cccaagtact attctcagcc cattctcgtg aaggaaatca     2640

tagaacctcc aaagattcgc attccaagac acctgaagca aacctatatc cgcagagttg     2700

gagaagctgt caatctggtt atacctttcc agggaaaacc aagaccagaa ttaacttgga     2760

agaaggatgg tgcagaaatt gataagaatc aaataaacat tcgcaactct gagactgata     2820

caatcatatt tattagaaaa gcagagagga gccactctgg gaaatatgat ctgcaagtca     2880

aagtggacaa attcgtggag accgcatcaa ttgacatcca gatcattgac cgtccaggtc     2940

caccccaaat tgtgaagatt gaggatgtct ggggagaaaa tgtcgctctc acatggactc     3000

caccaaagga tgatggaaat gctgctatca caggctatac cattcagaag gctgacaaga     3060

agagcatgga atggtttact gtcattgagc attatcatcg aaccagtgcc accattactg     3120

aattggtcat agggaatgaa tattacttcc gggtcttttc tgaaaacatg tgtggcctca     3180

gtgaggatgc caccatgact aaagagagtg cagtgatcgc cagggatggt aaaatctaca     3240

aaaatccagt gtatgaagac tttgatttct cagaggcacc catgtttact cagcctttgg     3300

ttaacaccta tgccatagct ggttacaatg ccaccctaaa ctgcagtgtg agaggaaatc     3360

ctaagcctaa aataacctgg atgaaaaaca aagttgctat tgtggatgat ccaagataca     3420

ggatgttcag caaccaggga gtctgtaccc tggaaattcg caagcccagc ccctatgatg     3480

gaggcactta ctgctgcaaa gcagtcaatg accttgggac agtggagatt gaatgcaaac     3540

tggaggtgaa agtcattgca caataaggat ttttgaatgt ataatatcat ctaaggtggg     3600

ctctccttct gcagactcct cttgcaaggc gtacctccaa acataattga ttcgtatctg     3660

cgagacttac actcaagcaa tcctgaggaa tactgaggga gggcctggct actgtctctc     3720

tgcactctgc tgctttgaaa tctggttgaa atgagaaaaa gcattttctg ttttcccacc     3780

aggcccccaa gtgtggtctt tttctttcct cctaatgttg aagagaaaaa aaaaaaaaaa     3840

agtttgccca gattgcttaa ttaaaaattg caaacaaaat ctcatttgaa gtcaaaaaaa     3900

aaaaaaaaaa aaaa                                                       3914


<210>  73
<211>  3860
<212>  DNA
<213>  Homo sapiens

<400>  73
agaggcagta taaaagcact gggtttctcc ccaactgctt gtcacaccga cctgcaccat       60

ctctcgcctg cctgtggggt ttctgtcaac tagtcgtgga gggaaggaga ctctttaaag      120

aataacatct tattgtggcc atgccagaac ccactaagaa agaggaaaat gaagtgccag      180

ccccagcccc acccccggaa gaaccaagta aagagaagga ggccggaact acaccagcaa      240

aagactggac ccttgtcgaa actcctcctg gggaggaaca agccaagcag aatgccaact      300

cccagctgtc catcttgttc attgaaaaac ctcaaggagg aacagtgaaa gttggtgaag      360

atatcacctt catagccaaa gtcaaggctg aagatcttct gagaaaaccc actatcaaat      420

ggttcaaagg aaaatggatg gacctggcca gcaaagccgg gaagcacctt cagctgaagg      480

aaacctttga gaggcacagt cgggtgtaca catttgagat gcagatcatc aaggccaaag      540

ataactttgc aggaaattac agatgcgagg tcacctataa ggataagttt gacagctgtt      600

catttgatct tgaagtgcac gaatctactg ggactactcc aaacattgac atcagatctg      660

ctttcaagag aagtggagaa ggtcaagagg atgcaggaga acttgacttt agtggtctcc      720

tgaaacgtag ggaggtgaag cagcaggagg aagaacccca ggtggacgta tgggagttgc      780

tgaagaacgc gaaacccagt gagtacgaga agatcgcctt ccagtatgga atcaccgacc      840

tgcgcggcat gctcaagcga ctcaagcgca tgcgcagaga ggagaagaag agcgcagctt      900

ttgcaaaaat tcttgatcct gcatatcagg ttgacaaagg aggcagagtg aggtttgttg      960

tggagctggc agatccaaag ttggaggtga aatggtataa aaatggtcaa gaaattcgac     1020

ccagtaccaa atacatcttt gaacacaaag gatgccagag aatcctgttt atcaataact     1080

gtcagatgac agatgattca gagtattatg tgacagccgg tgatgagaaa tgttccactg     1140

agctcttcgt aagagagcct ccaattatgg tgaccaaaca gctggaagat acaactgctt     1200

attgtgggga gagagtggaa ttagaatgtg aggtgtctga agatgatgcc aatgtaaaat     1260

ggtttaagaa tggtgaagag attatccctg gtccaaaatc aagataccga attagagttg     1320

agggtaaaaa acacatcttg atcatagagg gagcaacaaa ggctgatgct gcagaatatt     1380

cagtaatgac aacaggagga caatcatctg ctaaacttag tgttgacttg aaacctctga     1440

agattttgac acctctgact gatcagactg taaatcttgg aaaagaaatc tgcctgaagt     1500

gtgaaatctc tgaaaacata ccaggaaaat ggactaaaaa tggcctacct gttcaggaga     1560

gtgaccgtct aaaggtggtt cacaagggaa ggatccacaa gttagtgata gccaatgccc     1620

tcactgaaga tgaaggtgat tatgtatttg cacctgatgc ctacaatgtt actctgcctg     1680

ccaaagttca tgttattgat cctcctaaga tcatcctgga tggtcttgat gctgacaaca     1740

cagtgacagt gattgcagga aacaagcttc gtcttgagat ccccatcagc ggagaaccac     1800

ctcctaaagc catgtggagc cggggagata aggctattat ggaaggcagt ggccggataa     1860

gaacagaatc ttaccctgat agcagcactc tggtcattga tatagctgaa agagatgact     1920

ctggtgttta ccacatcaat ctgaaaaacg aagctggaga ggcacatgca agcatcaagg     1980

ttaaagttgt ggacttccct gatcctccag tggcaccgac tgtgacagag gtgggagatg     2040

actggtgtat catgaactgg gagcctcctg cctacgacgg aggctctcca atcctaggat     2100

attttattga gaggaagaag aaacaaagct ccaggtggat gaggctgaat tttgatctct     2160

gcaaagaaac aacttttgag cccaagaaga tgattgaagg tgtggcctat gaggtccgca     2220

tctttgcagt caatgccatt ggcatctcca agcccagtat gccctccagg ccttttgttc     2280

ctttggctgt aacaagccct cctactcttc tgactgtgga ctctgtcact gacacgactg     2340

tcacgatgag gtggcgcccc ccagaccaca ttggtgcagc aggtttagat ggctatgtgc     2400

tagagtattg ctttgaagga actgaggact ggatagttgc aaacaaagat ctgattgaca     2460

agacgaagtt caccatcaca ggtctgccaa cagatgcaaa gatctttgtg cgtgtgaagg     2520

ctgttaatgc agctggtgcc agcgagccca agtactattc tcagcccatt ctcgtgaagg     2580

aaatcataga acctccaaag attcgcattc caagacacct gaagcaaacc tatatccgca     2640

gagttggaga agctgtcaat ctggttatac ctttccaggg aaaaccaaga ccagaattaa     2700

cttggaagaa ggatggtgca gaaattgata agaatcaaat aaacattcgc aactctgaga     2760

ctgatacaat catatttatt agaaaagcag agaggagcca ctctgggaaa tatgatctgc     2820

aagtcaaagt ggacaaattc gtggagaccg catcaattga catccagatc attgaccgtc     2880

caggtccacc ccaaattgtg aagattgagg atgtctgggg agaaaatgtc gctctcacat     2940

ggactccacc aaaggatgat ggaaatgctg ctatcacagg ctataccatt cagaaggctg     3000

acaagaagag catggaatgg tttactgtca ttgagcatta tcatcgaacc agtgccacca     3060

ttactgaatt ggtcataggg aatgaatatt acttccgggt cttttctgaa aacatgtgtg     3120

gcctcagtga ggatgccacc atgactaaag agagtgcagt gatcgccagg gatggtaaaa     3180

tctacaaaaa tccagtgtat gaagactttg atttctcaga ggcacccatg tttactcagc     3240

ctttggttaa cacctatgcc atagctggtt acaatgccac cctaaactgc agtgtgagag     3300

gaaatcctaa gcctaaaata acctggatga aaaacaaagt tgctattgtg gatgatccaa     3360

gatacaggat gttcagcaac cagggagtct gtaccctgga aattcgcaag cccagcccct     3420

atgatggagg cacttactgc tgcaaagcag tcaatgacct tgggacagtg gagattgaat     3480

gcaaactgga ggtgaaagtc attgcacaat aaggattttt gaatgtataa tatcatctaa     3540

ggtgggctct ccttctgcag actcctcttg caaggcgtac ctccaaacat aattgattcg     3600

tatctgcgag acttacactc aagcaatcct gaggaatact gagggagggc ctggctactg     3660

tctctctgca ctctgctgct ttgaaatctg gttgaaatga gaaaaagcat tttctgtttt     3720

cccaccaggc ccccaagtgt ggtctttttc tttcctccta atgttgaaga gaaaaaaaaa     3780

aaaaaaagtt tgcccagatt gcttaattaa aaattgcaaa caaaatctca tttgaagtca     3840

aaaaaaaaaa aaaaaaaaaa                                                 3860


<210>  74
<211>  1173
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala 
        35                  40                  45              


Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro 
    50                  55                  60                  


Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys 
65                  70                  75                  80  


Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys Trp Phe Lys 
                85                  90                  95      


Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu 
            100                 105                 110         


Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln 
        115                 120                 125             


Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val 
    130                 135                 140                 


Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His 
145                 150                 155                 160 


Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys 
                165                 170                 175     


Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp Phe Ser Gly 
            180                 185                 190         


Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val 
        195                 200                 205             


Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu Tyr Glu Lys 
    210                 215                 220                 


Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met Leu Lys Arg 
225                 230                 235                 240 


Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys 
                245                 250                 255     


Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe 
            260                 265                 270         


Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Tyr Lys Asn 
        275                 280                 285             


Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu His Lys Gly 
    290                 295                 300                 


Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met Thr Asp Asp Ser 
305                 310                 315                 320 


Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Phe 
                325                 330                 335     


Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr 
            340                 345                 350         


Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp 
        355                 360                 365             


Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Pro Gly 
    370                 375                 380                 


Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu 
385                 390                 395                 400 


Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr Ser Val Met 
                405                 410                 415     


Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro 
            420                 425                 430         


Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys 
        435                 440                 445             


Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp 
    450                 455                 460                 


Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val 
465                 470                 475                 480 


His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn Ala Leu Thr Glu 
                485                 490                 495     


Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu 
            500                 505                 510         


Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly 
        515                 520                 525             


Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg 
    530                 535                 540                 


Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser 
545                 550                 555                 560 


Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu 
                565                 570                 575     


Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp 
            580                 585                 590         


Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala 
        595                 600                 605             


His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val 
    610                 615                 620                 


Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp 
625                 630                 635                 640 


Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile 
                645                 650                 655     


Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp 
            660                 665                 670         


Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val 
        675                 680                 685             


Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys 
    690                 695                 700                 


Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro 
705                 710                 715                 720 


Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met 
                725                 730                 735     


Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr 
            740                 745                 750         


Val Leu Glu Tyr Cys Phe Glu Gly Ser Thr Ser Ala Lys Gln Ser Asp 
        755                 760                 765             


Glu Asn Gly Glu Ala Ala Tyr Asp Leu Pro Ala Glu Asp Trp Ile Val 
    770                 775                 780                 


Ala Asn Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu 
785                 790                 795                 800 


Pro Thr Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala 
                805                 810                 815     


Gly Ala Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu 
            820                 825                 830         


Ile Ile Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys Gln Thr 
        835                 840                 845             


Tyr Ile Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro Phe Gln 
    850                 855                 860                 


Gly Lys Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile 
865                 870                 875                 880 


Asp Lys Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile 
                885                 890                 895     


Phe Ile Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln 
            900                 905                 910         


Val Lys Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Gln Ile 
        915                 920                 925             


Ile Asp Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp 
    930                 935                 940                 


Gly Glu Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn 
945                 950                 955                 960 


Ala Ala Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met 
                965                 970                 975     


Glu Trp Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala Thr Ile 
            980                 985                 990         


Thr Glu Leu Val Ile Gly Asn Glu  Tyr Tyr Phe Arg Val  Phe Ser Glu 
        995                 1000                 1005             


Asn Met  Cys Gly Leu Ser Glu  Asp Ala Thr Met Thr  Lys Glu Ser 
    1010                 1015                 1020             


Ala Val  Ile Ala Arg Asp Gly  Lys Ile Tyr Lys Asn  Pro Val Tyr 
    1025                 1030                 1035             


Glu Asp  Phe Asp Phe Ser Glu  Ala Pro Met Phe Thr  Gln Pro Leu 
    1040                 1045                 1050             


Val Asn  Thr Tyr Ala Ile Ala  Gly Tyr Asn Ala Thr  Leu Asn Cys 
    1055                 1060                 1065             


Ser Val  Arg Gly Asn Pro Lys  Pro Lys Ile Thr Trp  Met Lys Asn 
    1070                 1075                 1080             


Lys Val  Ala Ile Val Asp Asp  Pro Arg Tyr Arg Met  Phe Ser Asn 
    1085                 1090                 1095             


Gln Gly  Val Cys Thr Leu Glu  Ile Arg Lys Pro Ser  Pro Tyr Asp 
    1100                 1105                 1110             


Gly Gly  Thr Tyr Cys Cys Lys  Ala Val Asn Asp Leu  Gly Thr Val 
    1115                 1120                 1125             


Glu Ile  Glu Cys Lys Leu Glu  Val Lys Val Ile Tyr  Gln Gly Val 
    1130                 1135                 1140             


Asn Thr  Pro Gly Gln Pro Val  Phe Leu Glu Gly Gln  Gln Gln Val 
    1145                 1150                 1155             


Gly Ser  Pro Ser Ala Asp Ser  Ser Cys Lys Ala Tyr  Leu Gln Thr 
    1160                 1165                 1170             


<210>  75
<211>  1146
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala 
        35                  40                  45              


Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro 
    50                  55                  60                  


Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys 
65                  70                  75                  80  


Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys Trp Phe Lys 
                85                  90                  95      


Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu 
            100                 105                 110         


Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln 
        115                 120                 125             


Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val 
    130                 135                 140                 


Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His 
145                 150                 155                 160 


Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys 
                165                 170                 175     


Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp Phe Ser Gly 
            180                 185                 190         


Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val 
        195                 200                 205             


Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu Tyr Glu Lys 
    210                 215                 220                 


Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met Leu Lys Arg 
225                 230                 235                 240 


Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys 
                245                 250                 255     


Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe 
            260                 265                 270         


Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Tyr Lys Asn 
        275                 280                 285             


Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu His Lys Gly 
    290                 295                 300                 


Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met Thr Asp Asp Ser 
305                 310                 315                 320 


Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Phe 
                325                 330                 335     


Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr 
            340                 345                 350         


Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp 
        355                 360                 365             


Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Pro Gly 
    370                 375                 380                 


Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu 
385                 390                 395                 400 


Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr Ser Val Met 
                405                 410                 415     


Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro 
            420                 425                 430         


Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys 
        435                 440                 445             


Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp 
    450                 455                 460                 


Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val 
465                 470                 475                 480 


His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn Ala Leu Thr Glu 
                485                 490                 495     


Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu 
            500                 505                 510         


Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly 
        515                 520                 525             


Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg 
    530                 535                 540                 


Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser 
545                 550                 555                 560 


Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu 
                565                 570                 575     


Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp 
            580                 585                 590         


Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala 
        595                 600                 605             


His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val 
    610                 615                 620                 


Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp 
625                 630                 635                 640 


Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile 
                645                 650                 655     


Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp 
            660                 665                 670         


Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val 
        675                 680                 685             


Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys 
    690                 695                 700                 


Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro 
705                 710                 715                 720 


Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met 
                725                 730                 735     


Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr 
            740                 745                 750         


Val Leu Glu Tyr Cys Phe Glu Gly Thr Glu Asp Trp Ile Val Ala Asn 
        755                 760                 765             


Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu Pro Thr 
    770                 775                 780                 


Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala Gly Ala 
785                 790                 795                 800 


Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu Ile Ile 
                805                 810                 815     


Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys Gln Thr Tyr Ile 
            820                 825                 830         


Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro Phe Gln Gly Lys 
        835                 840                 845             


Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile Asp Lys 
    850                 855                 860                 


Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile Phe Ile 
865                 870                 875                 880 


Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln Val Lys 
                885                 890                 895     


Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Gln Ile Ile Asp 
            900                 905                 910         


Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp Gly Glu 
        915                 920                 925             


Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn Ala Ala 
    930                 935                 940                 


Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met Glu Trp 
945                 950                 955                 960 


Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala Thr Ile Thr Glu 
                965                 970                 975     


Leu Val Ile Gly Asn Glu Tyr Tyr Phe Arg Val Phe Ser Glu Asn Met 
            980                 985                 990         


Cys Gly Leu Ser Glu Asp Ala Thr  Met Thr Lys Glu Ser  Ala Val Ile 
        995                 1000                 1005             


Ala Arg  Asp Gly Lys Ile Tyr  Lys Asn Pro Val Tyr  Glu Asp Phe 
    1010                 1015                 1020             


Asp Phe  Ser Glu Ala Pro Met  Phe Thr Gln Pro Leu  Val Asn Thr 
    1025                 1030                 1035             


Tyr Ala  Ile Ala Gly Tyr Asn  Ala Thr Leu Asn Cys  Ser Val Arg 
    1040                 1045                 1050             


Gly Asn  Pro Lys Pro Lys Ile  Thr Trp Met Lys Asn  Lys Val Ala 
    1055                 1060                 1065             


Ile Val  Asp Asp Pro Arg Tyr  Arg Met Phe Ser Asn  Gln Gly Val 
    1070                 1075                 1080             


Cys Thr  Leu Glu Ile Arg Lys  Pro Ser Pro Tyr Asp  Gly Gly Thr 
    1085                 1090                 1095             


Tyr Cys  Cys Lys Ala Val Asn  Asp Leu Gly Thr Val  Glu Ile Glu 
    1100                 1105                 1110             


Cys Lys  Leu Glu Val Lys Val  Ile Tyr Gln Gly Val  Asn Thr Pro 
    1115                 1120                 1125             


Gly Gln  Pro Val Phe Leu Glu  Gly Gln Gln Gln Ser  Leu His Asn 
    1130                 1135                 1140             


Lys Asp  Phe 
    1145     


<210>  76
<211>  1134
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Pro Glu Pro Thr Lys Lys Glu Glu Pro Ser Lys Glu Lys Glu Ala 
1               5                   10                  15      


Gly Thr Thr Pro Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly 
            20                  25                  30          


Glu Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe 
        35                  40                  45              


Ile Glu Lys Pro Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr 
    50                  55                  60                  


Phe Ile Ala Lys Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile 
65                  70                  75                  80  


Lys Trp Phe Lys Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys 
                85                  90                  95      


His Leu Gln Leu Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr 
            100                 105                 110         


Phe Glu Met Gln Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr 
        115                 120                 125             


Arg Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp 
    130                 135                 140                 


Leu Glu Val His Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg 
145                 150                 155                 160 


Ser Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu 
                165                 170                 175     


Asp Phe Ser Gly Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu 
            180                 185                 190         


Glu Pro Gln Val Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser 
        195                 200                 205             


Glu Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly 
    210                 215                 220                 


Met Leu Lys Arg Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala 
225                 230                 235                 240 


Ala Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly 
                245                 250                 255     


Arg Val Arg Phe Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys 
            260                 265                 270         


Trp Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe 
        275                 280                 285             


Glu His Lys Gly Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met 
    290                 295                 300                 


Thr Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser 
305                 310                 315                 320 


Thr Glu Leu Phe Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu 
                325                 330                 335     


Glu Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu 
            340                 345                 350         


Val Ser Glu Asp Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu 
        355                 360                 365             


Ile Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys 
    370                 375                 380                 


Lys His Ile Leu Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu 
385                 390                 395                 400 


Tyr Ser Val Met Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val 
                405                 410                 415     


Asp Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val 
            420                 425                 430         


Asn Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile 
        435                 440                 445             


Pro Gly Lys Trp Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg 
    450                 455                 460                 


Leu Lys Val Val His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn 
465                 470                 475                 480 


Ala Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr 
                485                 490                 495     


Asn Val Thr Leu Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile 
            500                 505                 510         


Ile Leu Asp Gly Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly 
        515                 520                 525             


Asn Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys 
    530                 535                 540                 


Ala Met Trp Ser Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg 
545                 550                 555                 560 


Ile Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile 
                565                 570                 575     


Ala Glu Arg Asp Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu 
            580                 585                 590         


Ala Gly Glu Ala His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro 
        595                 600                 605             


Asp Pro Pro Val Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys 
    610                 615                 620                 


Ile Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu 
625                 630                 635                 640 


Gly Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg 
                645                 650                 655     


Leu Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met 
            660                 665                 670         


Ile Glu Gly Val Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile 
        675                 680                 685             


Gly Ile Ser Lys Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala 
    690                 695                 700                 


Val Thr Ser Pro Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr 
705                 710                 715                 720 


Thr Val Thr Met Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly 
                725                 730                 735     


Leu Asp Gly Tyr Val Leu Glu Tyr Cys Phe Glu Gly Thr Glu Asp Trp 
            740                 745                 750         


Ile Val Ala Asn Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr 
        755                 760                 765             


Gly Leu Pro Thr Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn 
    770                 775                 780                 


Ala Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val 
785                 790                 795                 800 


Lys Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys 
                805                 810                 815     


Gln Thr Tyr Ile Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro 
            820                 825                 830         


Phe Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala 
        835                 840                 845             


Glu Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr 
    850                 855                 860                 


Ile Ile Phe Ile Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp 
865                 870                 875                 880 


Leu Gln Val Lys Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile 
                885                 890                 895     


Gln Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp 
            900                 905                 910         


Val Trp Gly Glu Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp 
        915                 920                 925             


Gly Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys 
    930                 935                 940                 


Ser Met Glu Trp Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala 
945                 950                 955                 960 


Thr Ile Thr Glu Leu Val Ile Gly Asn Glu Tyr Tyr Phe Arg Val Phe 
                965                 970                 975     


Ser Glu Asn Met Cys Gly Leu Ser Glu Asp Ala Thr Met Thr Lys Glu 
            980                 985                 990         


Ser Ala Val Ile Ala Arg Asp Gly  Lys Ile Tyr Lys Asn  Pro Val Tyr 
        995                 1000                 1005             


Glu Asp  Phe Asp Phe Ser Glu  Ala Pro Met Phe Thr  Gln Pro Leu 
    1010                 1015                 1020             


Val Asn  Thr Tyr Ala Ile Ala  Gly Tyr Asn Ala Thr  Leu Asn Cys 
    1025                 1030                 1035             


Ser Val  Arg Gly Asn Pro Lys  Pro Lys Ile Thr Trp  Met Lys Asn 
    1040                 1045                 1050             


Lys Val  Ala Ile Val Asp Asp  Pro Arg Tyr Arg Met  Phe Ser Asn 
    1055                 1060                 1065             


Gln Gly  Val Cys Thr Leu Glu  Ile Arg Lys Pro Ser  Pro Tyr Asp 
    1070                 1075                 1080             


Gly Gly  Thr Tyr Cys Cys Lys  Ala Val Asn Asp Leu  Gly Thr Val 
    1085                 1090                 1095             


Glu Ile  Glu Cys Lys Leu Glu  Val Lys Val Ile Tyr  Gln Gly Val 
    1100                 1105                 1110             


Asn Thr  Pro Gly Gln Pro Val  Phe Leu Glu Gly Gln  Gln Gln Ser 
    1115                 1120                 1125             


Leu His  Asn Lys Asp Phe 
    1130                 


<210>  77
<211>  1127
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala 
        35                  40                  45              


Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro 
    50                  55                  60                  


Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys 
65                  70                  75                  80  


Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys Trp Phe Lys 
                85                  90                  95      


Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu 
            100                 105                 110         


Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln 
        115                 120                 125             


Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val 
    130                 135                 140                 


Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His 
145                 150                 155                 160 


Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys 
                165                 170                 175     


Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val Asp Val Trp 
            180                 185                 190         


Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu Tyr Glu Lys Ile Ala Phe 
        195                 200                 205             


Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys Arg 
    210                 215                 220                 


Met Arg Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys Ile Leu Asp 
225                 230                 235                 240 


Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe Val Val Glu 
                245                 250                 255     


Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Tyr Lys Asn Gly Gln Glu 
            260                 265                 270         


Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu His Lys Gly Cys Gln Arg 
        275                 280                 285             


Ile Leu Phe Ile Asn Asn Cys Gln Met Thr Asp Asp Ser Glu Tyr Tyr 
    290                 295                 300                 


Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Phe Val Arg Glu 
305                 310                 315                 320 


Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr Ala Tyr Cys 
                325                 330                 335     


Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp Asp Ala Asn 
            340                 345                 350         


Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Pro Gly Pro Lys Ser 
        355                 360                 365             


Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu Ile Ile Glu 
    370                 375                 380                 


Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr Ser Val Met Thr Thr Gly 
385                 390                 395                 400 


Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro Leu Lys Ile 
                405                 410                 415     


Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys Glu Ile Cys 
            420                 425                 430         


Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp Thr Lys Asn 
        435                 440                 445             


Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val His Lys Gly 
    450                 455                 460                 


Arg Ile His Lys Leu Val Ile Ala Asn Ala Leu Thr Glu Asp Glu Gly 
465                 470                 475                 480 


Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu Pro Ala Lys 
                485                 490                 495     


Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly Leu Asp Ala 
            500                 505                 510         


Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg Leu Glu Ile 
        515                 520                 525             


Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser Arg Gly Asp 
    530                 535                 540                 


Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu Ser Tyr Pro 
545                 550                 555                 560 


Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp Asp Ser Gly 
                565                 570                 575     


Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala His Ala Ser 
            580                 585                 590         


Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val Ala Pro Thr 
        595                 600                 605             


Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp Glu Pro Pro 
    610                 615                 620                 


Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile Glu Arg Lys 
625                 630                 635                 640 


Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp Leu Cys Lys 
                645                 650                 655     


Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val Ala Tyr Glu 
            660                 665                 670         


Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys Pro Ser Met 
        675                 680                 685             


Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro Pro Thr Leu 
    690                 695                 700                 


Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met Arg Trp Arg 
705                 710                 715                 720 


Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr Val Leu Glu 
                725                 730                 735     


Tyr Cys Phe Glu Gly Thr Glu Asp Trp Ile Val Ala Asn Lys Asp Leu 
            740                 745                 750         


Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu Pro Thr Asp Ala Lys 
        755                 760                 765             


Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala Gly Ala Ser Glu Pro 
    770                 775                 780                 


Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu Ile Ile Glu Pro Pro 
785                 790                 795                 800 


Lys Ile Arg Ile Pro Arg His Leu Lys Gln Thr Tyr Ile Arg Arg Val 
                805                 810                 815     


Gly Glu Ala Val Asn Leu Val Ile Pro Phe Gln Gly Lys Pro Arg Pro 
            820                 825                 830         


Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile Asp Lys Asn Gln Ile 
        835                 840                 845             


Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile Phe Ile Arg Lys Ala 
    850                 855                 860                 


Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln Val Lys Val Asp Lys 
865                 870                 875                 880 


Phe Val Glu Thr Ala Ser Ile Asp Ile Gln Ile Ile Asp Arg Pro Gly 
                885                 890                 895     


Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp Gly Glu Asn Val Ala 
            900                 905                 910         


Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn Ala Ala Ile Thr Gly 
        915                 920                 925             


Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met Glu Trp Phe Thr Val 
    930                 935                 940                 


Ile Glu His Tyr His Arg Thr Ser Ala Thr Ile Thr Glu Leu Val Ile 
945                 950                 955                 960 


Gly Asn Glu Tyr Tyr Phe Arg Val Phe Ser Glu Asn Met Cys Gly Leu 
                965                 970                 975     


Ser Glu Asp Ala Thr Met Thr Lys Glu Ser Ala Val Ile Ala Arg Asp 
            980                 985                 990         


Gly Lys Ile Tyr Lys Asn Pro Val  Tyr Glu Asp Phe Asp  Phe Ser Glu 
        995                 1000                 1005             


Ala Pro  Met Phe Thr Gln Pro  Leu Val Asn Thr Tyr  Ala Ile Ala 
    1010                 1015                 1020             


Gly Tyr  Asn Ala Thr Leu Asn  Cys Ser Val Arg Gly  Asn Pro Lys 
    1025                 1030                 1035             


Pro Lys  Ile Thr Trp Met Lys  Asn Lys Val Ala Ile  Val Asp Asp 
    1040                 1045                 1050             


Pro Arg  Tyr Arg Met Phe Ser  Asn Gln Gly Val Cys  Thr Leu Glu 
    1055                 1060                 1065             


Ile Arg  Lys Pro Ser Pro Tyr  Asp Gly Gly Thr Tyr  Cys Cys Lys 
    1070                 1075                 1080             


Ala Val  Asn Asp Leu Gly Thr  Val Glu Ile Glu Cys  Lys Leu Glu 
    1085                 1090                 1095             


Val Lys  Val Ile Tyr Gln Gly  Val Asn Thr Pro Gly  Gln Pro Val 
    1100                 1105                 1110             


Phe Leu  Glu Gly Gln Gln Gln  Ser Leu His Asn Lys  Asp Phe 
    1115                 1120                 1125         


<210>  78
<211>  1120
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Pro Glu Pro Thr Lys Lys Glu Asp Trp Thr Leu Val Glu Thr Pro 
1               5                   10                  15      


Pro Gly Glu Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile 
            20                  25                  30          


Leu Phe Ile Glu Lys Pro Gln Gly Gly Thr Val Lys Val Gly Glu Asp 
        35                  40                  45              


Ile Thr Phe Ile Ala Lys Val Lys Ala Glu Asp Leu Leu Arg Lys Pro 
    50                  55                  60                  


Thr Ile Lys Trp Phe Lys Gly Lys Trp Met Asp Leu Ala Ser Lys Ala 
65                  70                  75                  80  


Gly Lys His Leu Gln Leu Lys Glu Thr Phe Glu Arg His Ser Arg Val 
                85                  90                  95      


Tyr Thr Phe Glu Met Gln Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly 
            100                 105                 110         


Asn Tyr Arg Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser 
        115                 120                 125             


Phe Asp Leu Glu Val His Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp 
    130                 135                 140                 


Ile Arg Ser Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly 
145                 150                 155                 160 


Glu Leu Asp Phe Ser Gly Leu Leu Lys Arg Arg Glu Val Lys Gln Gln 
                165                 170                 175     


Glu Glu Glu Pro Gln Val Asp Val Trp Glu Leu Leu Lys Asn Ala Lys 
            180                 185                 190         


Pro Ser Glu Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu 
        195                 200                 205             


Arg Gly Met Leu Lys Arg Leu Lys Arg Met Arg Arg Glu Glu Lys Lys 
    210                 215                 220                 


Ser Ala Ala Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys 
225                 230                 235                 240 


Gly Gly Arg Val Arg Phe Val Val Glu Leu Ala Asp Pro Lys Leu Glu 
                245                 250                 255     


Val Lys Trp Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr 
            260                 265                 270         


Ile Phe Glu His Lys Gly Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys 
        275                 280                 285             


Gln Met Thr Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys 
    290                 295                 300                 


Cys Ser Thr Glu Leu Phe Val Arg Glu Pro Pro Ile Met Val Thr Lys 
305                 310                 315                 320 


Gln Leu Glu Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu 
                325                 330                 335     


Cys Glu Val Ser Glu Asp Asp Ala Asn Val Lys Trp Phe Lys Asn Gly 
            340                 345                 350         


Glu Glu Ile Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu 
        355                 360                 365             


Gly Lys Lys His Ile Leu Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala 
    370                 375                 380                 


Ala Glu Tyr Ser Val Met Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu 
385                 390                 395                 400 


Ser Val Asp Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln 
                405                 410                 415     


Thr Val Asn Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu 
            420                 425                 430         


Asn Ile Pro Gly Lys Trp Thr Lys Asn Gly Leu Pro Val Gln Glu Ser 
        435                 440                 445             


Asp Arg Leu Lys Val Val His Lys Gly Arg Ile His Lys Leu Val Ile 
    450                 455                 460                 


Ala Asn Ala Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp 
465                 470                 475                 480 


Ala Tyr Asn Val Thr Leu Pro Ala Lys Val His Val Ile Asp Pro Pro 
                485                 490                 495     


Lys Ile Ile Leu Asp Gly Leu Asp Ala Asp Asn Thr Val Thr Val Ile 
            500                 505                 510         


Ala Gly Asn Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro 
        515                 520                 525             


Pro Lys Ala Met Trp Ser Arg Gly Asp Lys Ala Ile Met Glu Gly Ser 
    530                 535                 540                 


Gly Arg Ile Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile 
545                 550                 555                 560 


Asp Ile Ala Glu Arg Asp Asp Ser Gly Val Tyr His Ile Asn Leu Lys 
                565                 570                 575     


Asn Glu Ala Gly Glu Ala His Ala Ser Ile Lys Val Lys Val Val Asp 
            580                 585                 590         


Phe Pro Asp Pro Pro Val Ala Pro Thr Val Thr Glu Val Gly Asp Asp 
        595                 600                 605             


Trp Cys Ile Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro 
    610                 615                 620                 


Ile Leu Gly Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp 
625                 630                 635                 640 


Met Arg Leu Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys 
                645                 650                 655     


Lys Met Ile Glu Gly Val Ala Tyr Glu Val Arg Ile Phe Ala Val Asn 
            660                 665                 670         


Ala Ile Gly Ile Ser Lys Pro Ser Met Pro Ser Arg Pro Phe Val Pro 
        675                 680                 685             


Leu Ala Val Thr Ser Pro Pro Thr Leu Leu Thr Val Asp Ser Val Thr 
    690                 695                 700                 


Asp Thr Thr Val Thr Met Arg Trp Arg Pro Pro Asp His Ile Gly Ala 
705                 710                 715                 720 


Ala Gly Leu Asp Gly Tyr Val Leu Glu Tyr Cys Phe Glu Gly Thr Glu 
                725                 730                 735     


Asp Trp Ile Val Ala Asn Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr 
            740                 745                 750         


Ile Thr Gly Leu Pro Thr Asp Ala Lys Ile Phe Val Arg Val Lys Ala 
        755                 760                 765             


Val Asn Ala Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile 
    770                 775                 780                 


Leu Val Lys Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile Pro Arg His 
785                 790                 795                 800 


Leu Lys Gln Thr Tyr Ile Arg Arg Val Gly Glu Ala Val Asn Leu Val 
                805                 810                 815     


Ile Pro Phe Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp 
            820                 825                 830         


Gly Ala Glu Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr 
        835                 840                 845             


Asp Thr Ile Ile Phe Ile Arg Lys Ala Glu Arg Ser His Ser Gly Lys 
    850                 855                 860                 


Tyr Asp Leu Gln Val Lys Val Asp Lys Phe Val Glu Thr Ala Ser Ile 
865                 870                 875                 880 


Asp Ile Gln Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile Val Lys Ile 
                885                 890                 895     


Glu Asp Val Trp Gly Glu Asn Val Ala Leu Thr Trp Thr Pro Pro Lys 
            900                 905                 910         


Asp Asp Gly Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp 
        915                 920                 925             


Lys Lys Ser Met Glu Trp Phe Thr Val Ile Glu His Tyr His Arg Thr 
    930                 935                 940                 


Ser Ala Thr Ile Thr Glu Leu Val Ile Gly Asn Glu Tyr Tyr Phe Arg 
945                 950                 955                 960 


Val Phe Ser Glu Asn Met Cys Gly Leu Ser Glu Asp Ala Thr Met Thr 
                965                 970                 975     


Lys Glu Ser Ala Val Ile Ala Arg Asp Gly Lys Ile Tyr Lys Asn Pro 
            980                 985                 990         


Val Tyr Glu Asp Phe Asp Phe Ser  Glu Ala Pro Met Phe  Thr Gln Pro 
        995                 1000                 1005             


Leu Val  Asn Thr Tyr Ala Ile  Ala Gly Tyr Asn Ala  Thr Leu Asn 
    1010                 1015                 1020             


Cys Ser  Val Arg Gly Asn Pro  Lys Pro Lys Ile Thr  Trp Met Lys 
    1025                 1030                 1035             


Asn Lys  Val Ala Ile Val Asp  Asp Pro Arg Tyr Arg  Met Phe Ser 
    1040                 1045                 1050             


Asn Gln  Gly Val Cys Thr Leu  Glu Ile Arg Lys Pro  Ser Pro Tyr 
    1055                 1060                 1065             


Asp Gly  Gly Thr Tyr Cys Cys  Lys Ala Val Asn Asp  Leu Gly Thr 
    1070                 1075                 1080             


Val Glu  Ile Glu Cys Lys Leu  Glu Val Lys Val Ile  Tyr Gln Gly 
    1085                 1090                 1095             


Val Asn  Thr Pro Gly Gln Pro  Val Phe Leu Glu Gly  Gln Gln Gln 
    1100                 1105                 1110             


Ser Leu  His Asn Lys Asp Phe  
    1115                 1120 


<210>  79
<211>  1139
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Pro Glu Pro Thr Lys Lys Glu Asp Glu Glu Glu Val Ser Pro Pro 
1               5                   10                  15      


Ser Ala Leu Pro Pro Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu 
            20                  25                  30          


Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile 
        35                  40                  45              


Glu Lys Pro Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe 
    50                  55                  60                  


Ile Ala Lys Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys 
65                  70                  75                  80  


Trp Phe Lys Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His 
                85                  90                  95      


Leu Gln Leu Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe 
            100                 105                 110         


Glu Met Gln Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg 
        115                 120                 125             


Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu 
    130                 135                 140                 


Glu Val His Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser 
145                 150                 155                 160 


Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp 
                165                 170                 175     


Phe Ser Gly Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu 
            180                 185                 190         


Pro Gln Val Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu 
        195                 200                 205             


Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met 
    210                 215                 220                 


Leu Lys Arg Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala Ala 
225                 230                 235                 240 


Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg 
                245                 250                 255     


Val Arg Phe Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp 
            260                 265                 270         


Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu 
        275                 280                 285             


His Lys Gly Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met Thr 
    290                 295                 300                 


Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr 
305                 310                 315                 320 


Glu Leu Phe Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu 
                325                 330                 335     


Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val 
            340                 345                 350         


Ser Glu Asp Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu Ile 
        355                 360                 365             


Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys 
    370                 375                 380                 


His Ile Leu Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr 
385                 390                 395                 400 


Ser Val Met Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp 
                405                 410                 415     


Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn 
            420                 425                 430         


Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro 
        435                 440                 445             


Gly Lys Trp Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu 
    450                 455                 460                 


Lys Val Val His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn Ala 
465                 470                 475                 480 


Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn 
                485                 490                 495     


Val Thr Leu Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile Ile 
            500                 505                 510         


Leu Asp Gly Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn 
        515                 520                 525             


Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala 
    530                 535                 540                 


Met Trp Ser Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile 
545                 550                 555                 560 


Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala 
                565                 570                 575     


Glu Arg Asp Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala 
            580                 585                 590         


Gly Glu Ala His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp 
        595                 600                 605             


Pro Pro Val Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile 
    610                 615                 620                 


Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly 
625                 630                 635                 640 


Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu 
                645                 650                 655     


Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile 
            660                 665                 670         


Glu Gly Val Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly 
        675                 680                 685             


Ile Ser Lys Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val 
    690                 695                 700                 


Thr Ser Pro Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr 
705                 710                 715                 720 


Val Thr Met Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu 
                725                 730                 735     


Asp Gly Tyr Val Leu Glu Tyr Cys Phe Glu Gly Thr Glu Asp Trp Ile 
            740                 745                 750         


Val Ala Asn Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly 
        755                 760                 765             


Leu Pro Thr Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala 
    770                 775                 780                 


Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys 
785                 790                 795                 800 


Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys Gln 
                805                 810                 815     


Thr Tyr Ile Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro Phe 
            820                 825                 830         


Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu 
        835                 840                 845             


Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile 
    850                 855                 860                 


Ile Phe Ile Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu 
865                 870                 875                 880 


Gln Val Lys Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Gln 
                885                 890                 895     


Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val 
            900                 905                 910         


Trp Gly Glu Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly 
        915                 920                 925             


Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser 
    930                 935                 940                 


Met Glu Trp Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala Thr 
945                 950                 955                 960 


Ile Thr Glu Leu Val Ile Gly Asn Glu Tyr Tyr Phe Arg Val Phe Ser 
                965                 970                 975     


Glu Asn Met Cys Gly Leu Ser Glu Asp Ala Thr Met Thr Lys Glu Ser 
            980                 985                 990         


Ala Val Ile Ala Arg Asp Gly Lys  Ile Tyr Lys Asn Pro  Val Tyr Glu 
        995                 1000                 1005             


Asp Phe  Asp Phe Ser Glu Ala  Pro Met Phe Thr Gln  Pro Leu Val 
    1010                 1015                 1020             


Asn Thr  Tyr Ala Ile Ala Gly  Tyr Asn Ala Thr Leu  Asn Cys Ser 
    1025                 1030                 1035             


Val Arg  Gly Asn Pro Lys Pro  Lys Ile Thr Trp Met  Lys Asn Lys 
    1040                 1045                 1050             


Val Ala  Ile Val Asp Asp Pro  Arg Tyr Arg Met Phe  Ser Asn Gln 
    1055                 1060                 1065             


Gly Val  Cys Thr Leu Glu Ile  Arg Lys Pro Ser Pro  Tyr Asp Gly 
    1070                 1075                 1080             


Gly Thr  Tyr Cys Cys Lys Ala  Val Asn Asp Leu Gly  Thr Val Glu 
    1085                 1090                 1095             


Ile Glu  Cys Lys Leu Glu Val  Lys Gly Gly Leu Ser  Phe Cys Arg 
    1100                 1105                 1110             


Leu Leu  Leu Gln Gly Val Pro  Pro Asn Ile Ile Asp  Ser Tyr Leu 
    1115                 1120                 1125             


Arg Asp  Leu His Ser Ser Asn  Pro Glu Glu Tyr 
    1130                 1135                 


<210>  80
<211>  1171
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Glu Glu Glu Val Ser Pro Pro Ser Ala Leu Pro Pro Gly 
        35                  40                  45              


Leu Gly Ser Arg Ala Leu Glu Arg Lys Asp Ser Asp Trp Thr Leu Val 
    50                  55                  60                  


Glu Thr Pro Pro Gly Glu Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln 
65                  70                  75                  80  


Leu Ser Ile Leu Phe Ile Glu Lys Pro Gln Gly Gly Thr Val Lys Val 
                85                  90                  95      


Gly Glu Asp Ile Thr Phe Ile Ala Lys Val Lys Ala Glu Asp Leu Leu 
            100                 105                 110         


Arg Lys Pro Thr Ile Lys Trp Phe Lys Gly Lys Trp Met Asp Leu Ala 
        115                 120                 125             


Ser Lys Ala Gly Lys His Leu Gln Leu Lys Glu Thr Phe Glu Arg His 
    130                 135                 140                 


Ser Arg Val Tyr Thr Phe Glu Met Gln Ile Ile Lys Ala Lys Asp Asn 
145                 150                 155                 160 


Phe Ala Gly Asn Tyr Arg Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp 
                165                 170                 175     


Ser Cys Ser Phe Asp Leu Glu Val His Glu Ser Thr Gly Thr Thr Pro 
            180                 185                 190         


Asn Ile Asp Ile Arg Ser Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu 
        195                 200                 205             


Asp Ala Gly Glu Leu Asp Phe Ser Gly Leu Leu Lys Arg Arg Glu Val 
    210                 215                 220                 


Lys Gln Gln Glu Glu Glu Pro Gln Val Asp Val Trp Glu Leu Leu Lys 
225                 230                 235                 240 


Asn Ala Lys Pro Ser Glu Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile 
                245                 250                 255     


Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys Arg Met Arg Arg Glu 
            260                 265                 270         


Glu Lys Lys Ser Ala Ala Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln 
        275                 280                 285             


Val Asp Lys Gly Gly Arg Val Arg Phe Val Val Glu Leu Ala Asp Pro 
    290                 295                 300                 


Lys Leu Glu Val Lys Trp Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser 
305                 310                 315                 320 


Thr Lys Tyr Ile Phe Glu His Lys Gly Cys Gln Arg Ile Leu Phe Ile 
                325                 330                 335     


Asn Asn Cys Gln Met Thr Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly 
            340                 345                 350         


Asp Glu Lys Cys Ser Thr Glu Leu Phe Val Arg Glu Pro Pro Ile Met 
        355                 360                 365             


Val Thr Lys Gln Leu Glu Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val 
    370                 375                 380                 


Glu Leu Glu Cys Glu Val Ser Glu Asp Asp Ala Asn Val Lys Trp Phe 
385                 390                 395                 400 


Lys Asn Gly Glu Glu Ile Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile 
                405                 410                 415     


Arg Val Glu Gly Lys Lys His Ile Leu Ile Ile Glu Gly Ala Thr Lys 
            420                 425                 430         


Ala Asp Ala Ala Glu Tyr Ser Val Met Thr Thr Gly Gly Gln Ser Ser 
        435                 440                 445             


Ala Lys Leu Ser Val Asp Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu 
    450                 455                 460                 


Thr Asp Gln Thr Val Asn Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu 
465                 470                 475                 480 


Ile Ser Glu Asn Ile Pro Gly Lys Trp Thr Lys Asn Gly Leu Pro Val 
                485                 490                 495     


Gln Glu Ser Asp Arg Leu Lys Val Val His Lys Gly Arg Ile His Lys 
            500                 505                 510         


Leu Val Ile Ala Asn Ala Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe 
        515                 520                 525             


Ala Pro Asp Ala Tyr Asn Val Thr Leu Pro Ala Lys Val His Val Ile 
    530                 535                 540                 


Asp Pro Pro Lys Ile Ile Leu Asp Gly Leu Asp Ala Asp Asn Thr Val 
545                 550                 555                 560 


Thr Val Ile Ala Gly Asn Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly 
                565                 570                 575     


Glu Pro Pro Pro Lys Ala Met Trp Ser Arg Gly Asp Lys Ala Ile Met 
            580                 585                 590         


Glu Gly Ser Gly Arg Ile Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr 
        595                 600                 605             


Leu Val Ile Asp Ile Ala Glu Arg Asp Asp Ser Gly Val Tyr His Ile 
    610                 615                 620                 


Asn Leu Lys Asn Glu Ala Gly Glu Ala His Ala Ser Ile Lys Val Lys 
625                 630                 635                 640 


Val Val Asp Phe Pro Asp Pro Pro Val Ala Pro Thr Val Thr Glu Val 
                645                 650                 655     


Gly Asp Asp Trp Cys Ile Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly 
            660                 665                 670         


Gly Ser Pro Ile Leu Gly Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser 
        675                 680                 685             


Ser Arg Trp Met Arg Leu Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe 
    690                 695                 700                 


Glu Pro Lys Lys Met Ile Glu Gly Val Ala Tyr Glu Val Arg Ile Phe 
705                 710                 715                 720 


Ala Val Asn Ala Ile Gly Ile Ser Lys Pro Ser Met Pro Ser Arg Pro 
                725                 730                 735     


Phe Val Pro Leu Ala Val Thr Ser Pro Pro Thr Leu Leu Thr Val Asp 
            740                 745                 750         


Ser Val Thr Asp Thr Thr Val Thr Met Arg Trp Arg Pro Pro Asp His 
        755                 760                 765             


Ile Gly Ala Ala Gly Leu Asp Gly Tyr Val Leu Glu Tyr Cys Phe Glu 
    770                 775                 780                 


Gly Thr Glu Asp Trp Ile Val Ala Asn Lys Asp Leu Ile Asp Lys Thr 
785                 790                 795                 800 


Lys Phe Thr Ile Thr Gly Leu Pro Thr Asp Ala Lys Ile Phe Val Arg 
                805                 810                 815     


Val Lys Ala Val Asn Ala Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser 
            820                 825                 830         


Gln Pro Ile Leu Val Lys Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile 
        835                 840                 845             


Pro Arg His Leu Lys Gln Thr Tyr Ile Arg Arg Val Gly Glu Ala Val 
    850                 855                 860                 


Asn Leu Val Ile Pro Phe Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp 
865                 870                 875                 880 


Lys Lys Asp Gly Ala Glu Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn 
                885                 890                 895     


Ser Glu Thr Asp Thr Ile Ile Phe Ile Arg Lys Ala Glu Arg Ser His 
            900                 905                 910         


Ser Gly Lys Tyr Asp Leu Gln Val Lys Val Asp Lys Phe Val Glu Thr 
        915                 920                 925             


Ala Ser Ile Asp Ile Gln Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile 
    930                 935                 940                 


Val Lys Ile Glu Asp Val Trp Gly Glu Asn Val Ala Leu Thr Trp Thr 
945                 950                 955                 960 


Pro Pro Lys Asp Asp Gly Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln 
                965                 970                 975     


Lys Ala Asp Lys Lys Ser Met Glu Trp Phe Thr Val Ile Glu His Tyr 
            980                 985                 990         


His Arg Thr Ser Ala Thr Ile Thr  Glu Leu Val Ile Gly  Asn Glu Tyr 
        995                 1000                 1005             


Tyr Phe  Arg Val Phe Ser Glu  Asn Met Cys Gly Leu  Ser Glu Asp 
    1010                 1015                 1020             


Ala Thr  Met Thr Lys Glu Ser  Ala Val Ile Ala Arg  Asp Gly Lys 
    1025                 1030                 1035             


Ile Tyr  Lys Asn Pro Val Tyr  Glu Asp Phe Asp Phe  Ser Glu Ala 
    1040                 1045                 1050             


Pro Met  Phe Thr Gln Pro Leu  Val Asn Thr Tyr Ala  Ile Ala Gly 
    1055                 1060                 1065             


Tyr Asn  Ala Thr Leu Asn Cys  Ser Val Arg Gly Asn  Pro Lys Pro 
    1070                 1075                 1080             


Lys Ile  Thr Trp Met Lys Asn  Lys Val Ala Ile Val  Asp Asp Pro 
    1085                 1090                 1095             


Arg Tyr  Arg Met Phe Ser Asn  Gln Gly Val Cys Thr  Leu Glu Ile 
    1100                 1105                 1110             


Arg Lys  Pro Ser Pro Tyr Asp  Gly Gly Thr Tyr Cys  Cys Lys Ala 
    1115                 1120                 1125             


Val Asn  Asp Leu Gly Thr Val  Glu Ile Glu Cys Lys  Leu Glu Val 
    1130                 1135                 1140             


Lys Val  Ile Tyr Gln Gly Val  Asn Thr Pro Gly Gln  Pro Val Phe 
    1145                 1150                 1155             


Leu Glu  Gly Gln Gln Gln Ser  Leu His Asn Lys Asp  Phe 
    1160                 1165                 1170     


<210>  81
<211>  1148
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Glu Glu Glu Val Ser Pro Pro Ser Ala Leu Pro Pro Gly 
        35                  40                  45              


Leu Gly Ser Arg Ala Leu Glu Arg Lys Asp Ser Asp Trp Thr Leu Val 
    50                  55                  60                  


Glu Thr Pro Pro Gly Glu Glu Gln Ala Lys Gln Asn Ala Asn Ser Gln 
65                  70                  75                  80  


Leu Ser Ile Leu Phe Ile Glu Lys Pro Gln Gly Gly Thr Val Lys Val 
                85                  90                  95      


Gly Glu Asp Ile Thr Phe Ile Ala Lys Val Lys Ala Glu Asp Leu Leu 
            100                 105                 110         


Arg Lys Pro Thr Ile Lys Trp Phe Lys Gly Lys Trp Met Asp Leu Ala 
        115                 120                 125             


Ser Lys Ala Gly Lys His Leu Gln Leu Lys Glu Thr Phe Glu Arg His 
    130                 135                 140                 


Ser Arg Val Tyr Thr Phe Glu Met Gln Ile Ile Lys Ala Lys Asp Asn 
145                 150                 155                 160 


Phe Ala Gly Asn Tyr Arg Cys Glu Val Thr Tyr Lys Asp Lys Phe Asp 
                165                 170                 175     


Ser Cys Ser Phe Asp Leu Glu Val His Glu Ser Thr Gly Thr Thr Pro 
            180                 185                 190         


Asn Ile Asp Ile Arg Ser Ala Phe Lys Arg Ser Gly Glu Gly Gln Glu 
        195                 200                 205             


Asp Ala Gly Glu Leu Asp Phe Ser Gly Leu Leu Lys Arg Arg Glu Val 
    210                 215                 220                 


Lys Gln Gln Glu Glu Glu Pro Gln Val Asp Val Trp Glu Leu Leu Lys 
225                 230                 235                 240 


Asn Ala Lys Pro Ser Glu Tyr Glu Lys Ile Ala Phe Gln Tyr Gly Ile 
                245                 250                 255     


Thr Asp Leu Arg Gly Met Leu Lys Arg Leu Lys Arg Met Arg Arg Glu 
            260                 265                 270         


Glu Lys Lys Ser Ala Ala Phe Ala Lys Ile Leu Asp Pro Ala Tyr Gln 
        275                 280                 285             


Val Asp Lys Gly Gly Arg Val Arg Phe Val Val Glu Leu Ala Asp Pro 
    290                 295                 300                 


Lys Leu Glu Val Lys Trp Tyr Lys Asn Gly Gln Glu Ile Arg Pro Ser 
305                 310                 315                 320 


Thr Lys Tyr Ile Phe Glu His Lys Gly Cys Gln Arg Ile Leu Phe Ile 
                325                 330                 335     


Asn Asn Cys Gln Met Thr Asp Asp Ser Glu Tyr Tyr Val Thr Ala Gly 
            340                 345                 350         


Asp Glu Lys Cys Ser Thr Glu Leu Phe Val Arg Glu Pro Pro Ile Met 
        355                 360                 365             


Val Thr Lys Gln Leu Glu Asp Thr Thr Ala Tyr Cys Gly Glu Arg Val 
    370                 375                 380                 


Glu Leu Glu Cys Glu Val Ser Glu Asp Asp Ala Asn Val Lys Trp Phe 
385                 390                 395                 400 


Lys Asn Gly Glu Glu Ile Ile Pro Gly Pro Lys Ser Arg Tyr Arg Ile 
                405                 410                 415     


Arg Val Glu Gly Lys Lys His Ile Leu Ile Ile Glu Gly Ala Thr Lys 
            420                 425                 430         


Ala Asp Ala Ala Glu Tyr Ser Val Met Thr Thr Gly Gly Gln Ser Ser 
        435                 440                 445             


Ala Lys Leu Ser Val Asp Leu Lys Pro Leu Lys Ile Leu Thr Pro Leu 
    450                 455                 460                 


Thr Asp Gln Thr Val Asn Leu Gly Lys Glu Ile Cys Leu Lys Cys Glu 
465                 470                 475                 480 


Ile Ser Glu Asn Ile Pro Gly Lys Trp Thr Lys Asn Gly Leu Pro Val 
                485                 490                 495     


Gln Glu Ser Asp Arg Leu Lys Val Val His Lys Gly Arg Ile His Lys 
            500                 505                 510         


Leu Val Ile Ala Asn Ala Leu Thr Glu Asp Glu Gly Asp Tyr Val Phe 
        515                 520                 525             


Ala Pro Asp Ala Tyr Asn Val Thr Leu Pro Ala Lys Val His Val Ile 
    530                 535                 540                 


Asp Pro Pro Lys Ile Ile Leu Asp Gly Leu Asp Ala Asp Asn Thr Val 
545                 550                 555                 560 


Thr Val Ile Ala Gly Asn Lys Leu Arg Leu Glu Ile Pro Ile Ser Gly 
                565                 570                 575     


Glu Pro Pro Pro Lys Ala Met Trp Ser Arg Gly Asp Lys Ala Ile Met 
            580                 585                 590         


Glu Gly Ser Gly Arg Ile Arg Thr Glu Ser Tyr Pro Asp Ser Ser Thr 
        595                 600                 605             


Leu Val Ile Asp Ile Ala Glu Arg Asp Asp Ser Gly Val Tyr His Ile 
    610                 615                 620                 


Asn Leu Lys Asn Glu Ala Gly Glu Ala His Ala Ser Ile Lys Val Lys 
625                 630                 635                 640 


Val Val Asp Phe Pro Asp Pro Pro Val Ala Pro Thr Val Thr Glu Val 
                645                 650                 655     


Gly Asp Asp Trp Cys Ile Met Asn Trp Glu Pro Pro Ala Tyr Asp Gly 
            660                 665                 670         


Gly Ser Pro Ile Leu Gly Tyr Phe Ile Glu Arg Lys Lys Lys Gln Ser 
        675                 680                 685             


Ser Arg Trp Met Arg Leu Asn Phe Asp Leu Cys Lys Glu Thr Thr Phe 
    690                 695                 700                 


Glu Pro Lys Lys Met Ile Glu Gly Val Ala Tyr Glu Val Arg Ile Phe 
705                 710                 715                 720 


Ala Val Asn Ala Ile Gly Ile Ser Lys Pro Ser Met Pro Ser Arg Pro 
                725                 730                 735     


Phe Val Pro Leu Ala Val Thr Ser Pro Pro Thr Leu Leu Thr Val Asp 
            740                 745                 750         


Ser Val Thr Asp Thr Thr Val Thr Met Arg Trp Arg Pro Pro Asp His 
        755                 760                 765             


Ile Gly Ala Ala Gly Leu Asp Gly Tyr Val Leu Glu Tyr Cys Phe Glu 
    770                 775                 780                 


Gly Thr Glu Asp Trp Ile Val Ala Asn Lys Asp Leu Ile Asp Lys Thr 
785                 790                 795                 800 


Lys Phe Thr Ile Thr Gly Leu Pro Thr Asp Ala Lys Ile Phe Val Arg 
                805                 810                 815     


Val Lys Ala Val Asn Ala Ala Gly Ala Ser Glu Pro Lys Tyr Tyr Ser 
            820                 825                 830         


Gln Pro Ile Leu Val Lys Glu Ile Ile Glu Pro Pro Lys Ile Arg Ile 
        835                 840                 845             


Pro Arg His Leu Lys Gln Thr Tyr Ile Arg Arg Val Gly Glu Ala Val 
    850                 855                 860                 


Asn Leu Val Ile Pro Phe Gln Gly Lys Pro Arg Pro Glu Leu Thr Trp 
865                 870                 875                 880 


Lys Lys Asp Gly Ala Glu Ile Asp Lys Asn Gln Ile Asn Ile Arg Asn 
                885                 890                 895     


Ser Glu Thr Asp Thr Ile Ile Phe Ile Arg Lys Ala Glu Arg Ser His 
            900                 905                 910         


Ser Gly Lys Tyr Asp Leu Gln Val Lys Val Asp Lys Phe Val Glu Thr 
        915                 920                 925             


Ala Ser Ile Asp Ile Gln Ile Ile Asp Arg Pro Gly Pro Pro Gln Ile 
    930                 935                 940                 


Val Lys Ile Glu Asp Val Trp Gly Glu Asn Val Ala Leu Thr Trp Thr 
945                 950                 955                 960 


Pro Pro Lys Asp Asp Gly Asn Ala Ala Ile Thr Gly Tyr Thr Ile Gln 
                965                 970                 975     


Lys Ala Asp Lys Lys Ser Met Glu Trp Phe Thr Val Ile Glu His Tyr 
            980                 985                 990         


His Arg Thr Ser Ala Thr Ile Thr  Glu Leu Val Ile Gly  Asn Glu Tyr 
        995                 1000                 1005             


Tyr Phe  Arg Val Phe Ser Glu  Asn Met Cys Gly Leu  Ser Glu Asp 
    1010                 1015                 1020             


Ala Thr  Met Thr Lys Glu Ser  Ala Val Ile Ala Arg  Asp Gly Lys 
    1025                 1030                 1035             


Ile Tyr  Lys Asn Pro Val Tyr  Glu Asp Phe Asp Phe  Ser Glu Ala 
    1040                 1045                 1050             


Pro Met  Phe Thr Gln Pro Leu  Val Asn Thr Tyr Ala  Ile Ala Gly 
    1055                 1060                 1065             


Tyr Asn  Ala Thr Leu Asn Cys  Ser Val Arg Gly Asn  Pro Lys Pro 
    1070                 1075                 1080             


Lys Ile  Thr Trp Met Lys Asn  Lys Val Ala Ile Val  Asp Asp Pro 
    1085                 1090                 1095             


Arg Tyr  Arg Met Phe Ser Asn  Gln Gly Val Cys Thr  Leu Glu Ile 
    1100                 1105                 1110             


Arg Lys  Pro Ser Pro Tyr Asp  Gly Gly Thr Tyr Cys  Cys Lys Ala 
    1115                 1120                 1125             


Val Asn  Asp Leu Gly Thr Val  Glu Ile Glu Cys Lys  Leu Glu Val 
    1130                 1135                 1140             


Lys Val  Ile Ala Gln 
    1145             


<210>  82
<211>  1141
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala 
        35                  40                  45              


Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro 
    50                  55                  60                  


Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys 
65                  70                  75                  80  


Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys Trp Phe Lys 
                85                  90                  95      


Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu 
            100                 105                 110         


Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln 
        115                 120                 125             


Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val 
    130                 135                 140                 


Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His 
145                 150                 155                 160 


Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys 
                165                 170                 175     


Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp Phe Ser Gly 
            180                 185                 190         


Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val 
        195                 200                 205             


Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu Tyr Glu Lys 
    210                 215                 220                 


Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met Leu Lys Arg 
225                 230                 235                 240 


Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys 
                245                 250                 255     


Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe 
            260                 265                 270         


Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Tyr Lys Asn 
        275                 280                 285             


Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu His Lys Gly 
    290                 295                 300                 


Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met Thr Asp Asp Ser 
305                 310                 315                 320 


Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Phe 
                325                 330                 335     


Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr 
            340                 345                 350         


Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp 
        355                 360                 365             


Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Pro Gly 
    370                 375                 380                 


Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu 
385                 390                 395                 400 


Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr Ser Val Met 
                405                 410                 415     


Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro 
            420                 425                 430         


Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys 
        435                 440                 445             


Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp 
    450                 455                 460                 


Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val 
465                 470                 475                 480 


His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn Ala Leu Thr Glu 
                485                 490                 495     


Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu 
            500                 505                 510         


Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly 
        515                 520                 525             


Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg 
    530                 535                 540                 


Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser 
545                 550                 555                 560 


Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu 
                565                 570                 575     


Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp 
            580                 585                 590         


Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala 
        595                 600                 605             


His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val 
    610                 615                 620                 


Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp 
625                 630                 635                 640 


Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile 
                645                 650                 655     


Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp 
            660                 665                 670         


Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val 
        675                 680                 685             


Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys 
    690                 695                 700                 


Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro 
705                 710                 715                 720 


Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met 
                725                 730                 735     


Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr 
            740                 745                 750         


Val Leu Glu Tyr Cys Phe Glu Gly Ser Thr Ser Ala Lys Gln Ser Asp 
        755                 760                 765             


Glu Asn Gly Glu Ala Ala Tyr Asp Leu Pro Ala Glu Asp Trp Ile Val 
    770                 775                 780                 


Ala Asn Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu 
785                 790                 795                 800 


Pro Thr Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala 
                805                 810                 815     


Gly Ala Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu 
            820                 825                 830         


Ile Ile Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys Gln Thr 
        835                 840                 845             


Tyr Ile Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro Phe Gln 
    850                 855                 860                 


Gly Lys Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile 
865                 870                 875                 880 


Asp Lys Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile 
                885                 890                 895     


Phe Ile Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln 
            900                 905                 910         


Val Lys Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Gln Ile 
        915                 920                 925             


Ile Asp Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp 
    930                 935                 940                 


Gly Glu Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn 
945                 950                 955                 960 


Ala Ala Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met 
                965                 970                 975     


Glu Trp Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala Thr Ile 
            980                 985                 990         


Thr Glu Leu Val Ile Gly Asn Glu  Tyr Tyr Phe Arg Val  Phe Ser Glu 
        995                 1000                 1005             


Asn Met  Cys Gly Leu Ser Glu  Asp Ala Thr Met Thr  Lys Glu Ser 
    1010                 1015                 1020             


Ala Val  Ile Ala Arg Asp Gly  Lys Ile Tyr Lys Asn  Pro Val Tyr 
    1025                 1030                 1035             


Glu Asp  Phe Asp Phe Ser Glu  Ala Pro Met Phe Thr  Gln Pro Leu 
    1040                 1045                 1050             


Val Asn  Thr Tyr Ala Ile Ala  Gly Tyr Asn Ala Thr  Leu Asn Cys 
    1055                 1060                 1065             


Ser Val  Arg Gly Asn Pro Lys  Pro Lys Ile Thr Trp  Met Lys Asn 
    1070                 1075                 1080             


Lys Val  Ala Ile Val Asp Asp  Pro Arg Tyr Arg Met  Phe Ser Asn 
    1085                 1090                 1095             


Gln Gly  Val Cys Thr Leu Glu  Ile Arg Lys Pro Ser  Pro Tyr Asp 
    1100                 1105                 1110             


Gly Gly  Thr Tyr Cys Cys Lys  Ala Val Asn Asp Leu  Gly Thr Val 
    1115                 1120                 1125             


Glu Ile  Glu Cys Lys Leu Glu  Val Lys Val Ile Ala  Gln 
    1130                 1135                 1140     


<210>  83
<211>  1123
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Pro Glu Pro Thr Lys Lys Glu Glu Asn Glu Val Pro Ala Pro Ala 
1               5                   10                  15      


Pro Pro Pro Glu Glu Pro Ser Lys Glu Lys Glu Ala Gly Thr Thr Pro 
            20                  25                  30          


Ala Lys Asp Trp Thr Leu Val Glu Thr Pro Pro Gly Glu Glu Gln Ala 
        35                  40                  45              


Lys Gln Asn Ala Asn Ser Gln Leu Ser Ile Leu Phe Ile Glu Lys Pro 
    50                  55                  60                  


Gln Gly Gly Thr Val Lys Val Gly Glu Asp Ile Thr Phe Ile Ala Lys 
65                  70                  75                  80  


Val Lys Ala Glu Asp Leu Leu Arg Lys Pro Thr Ile Lys Trp Phe Lys 
                85                  90                  95      


Gly Lys Trp Met Asp Leu Ala Ser Lys Ala Gly Lys His Leu Gln Leu 
            100                 105                 110         


Lys Glu Thr Phe Glu Arg His Ser Arg Val Tyr Thr Phe Glu Met Gln 
        115                 120                 125             


Ile Ile Lys Ala Lys Asp Asn Phe Ala Gly Asn Tyr Arg Cys Glu Val 
    130                 135                 140                 


Thr Tyr Lys Asp Lys Phe Asp Ser Cys Ser Phe Asp Leu Glu Val His 
145                 150                 155                 160 


Glu Ser Thr Gly Thr Thr Pro Asn Ile Asp Ile Arg Ser Ala Phe Lys 
                165                 170                 175     


Arg Ser Gly Glu Gly Gln Glu Asp Ala Gly Glu Leu Asp Phe Ser Gly 
            180                 185                 190         


Leu Leu Lys Arg Arg Glu Val Lys Gln Gln Glu Glu Glu Pro Gln Val 
        195                 200                 205             


Asp Val Trp Glu Leu Leu Lys Asn Ala Lys Pro Ser Glu Tyr Glu Lys 
    210                 215                 220                 


Ile Ala Phe Gln Tyr Gly Ile Thr Asp Leu Arg Gly Met Leu Lys Arg 
225                 230                 235                 240 


Leu Lys Arg Met Arg Arg Glu Glu Lys Lys Ser Ala Ala Phe Ala Lys 
                245                 250                 255     


Ile Leu Asp Pro Ala Tyr Gln Val Asp Lys Gly Gly Arg Val Arg Phe 
            260                 265                 270         


Val Val Glu Leu Ala Asp Pro Lys Leu Glu Val Lys Trp Tyr Lys Asn 
        275                 280                 285             


Gly Gln Glu Ile Arg Pro Ser Thr Lys Tyr Ile Phe Glu His Lys Gly 
    290                 295                 300                 


Cys Gln Arg Ile Leu Phe Ile Asn Asn Cys Gln Met Thr Asp Asp Ser 
305                 310                 315                 320 


Glu Tyr Tyr Val Thr Ala Gly Asp Glu Lys Cys Ser Thr Glu Leu Phe 
                325                 330                 335     


Val Arg Glu Pro Pro Ile Met Val Thr Lys Gln Leu Glu Asp Thr Thr 
            340                 345                 350         


Ala Tyr Cys Gly Glu Arg Val Glu Leu Glu Cys Glu Val Ser Glu Asp 
        355                 360                 365             


Asp Ala Asn Val Lys Trp Phe Lys Asn Gly Glu Glu Ile Ile Pro Gly 
    370                 375                 380                 


Pro Lys Ser Arg Tyr Arg Ile Arg Val Glu Gly Lys Lys His Ile Leu 
385                 390                 395                 400 


Ile Ile Glu Gly Ala Thr Lys Ala Asp Ala Ala Glu Tyr Ser Val Met 
                405                 410                 415     


Thr Thr Gly Gly Gln Ser Ser Ala Lys Leu Ser Val Asp Leu Lys Pro 
            420                 425                 430         


Leu Lys Ile Leu Thr Pro Leu Thr Asp Gln Thr Val Asn Leu Gly Lys 
        435                 440                 445             


Glu Ile Cys Leu Lys Cys Glu Ile Ser Glu Asn Ile Pro Gly Lys Trp 
    450                 455                 460                 


Thr Lys Asn Gly Leu Pro Val Gln Glu Ser Asp Arg Leu Lys Val Val 
465                 470                 475                 480 


His Lys Gly Arg Ile His Lys Leu Val Ile Ala Asn Ala Leu Thr Glu 
                485                 490                 495     


Asp Glu Gly Asp Tyr Val Phe Ala Pro Asp Ala Tyr Asn Val Thr Leu 
            500                 505                 510         


Pro Ala Lys Val His Val Ile Asp Pro Pro Lys Ile Ile Leu Asp Gly 
        515                 520                 525             


Leu Asp Ala Asp Asn Thr Val Thr Val Ile Ala Gly Asn Lys Leu Arg 
    530                 535                 540                 


Leu Glu Ile Pro Ile Ser Gly Glu Pro Pro Pro Lys Ala Met Trp Ser 
545                 550                 555                 560 


Arg Gly Asp Lys Ala Ile Met Glu Gly Ser Gly Arg Ile Arg Thr Glu 
                565                 570                 575     


Ser Tyr Pro Asp Ser Ser Thr Leu Val Ile Asp Ile Ala Glu Arg Asp 
            580                 585                 590         


Asp Ser Gly Val Tyr His Ile Asn Leu Lys Asn Glu Ala Gly Glu Ala 
        595                 600                 605             


His Ala Ser Ile Lys Val Lys Val Val Asp Phe Pro Asp Pro Pro Val 
    610                 615                 620                 


Ala Pro Thr Val Thr Glu Val Gly Asp Asp Trp Cys Ile Met Asn Trp 
625                 630                 635                 640 


Glu Pro Pro Ala Tyr Asp Gly Gly Ser Pro Ile Leu Gly Tyr Phe Ile 
                645                 650                 655     


Glu Arg Lys Lys Lys Gln Ser Ser Arg Trp Met Arg Leu Asn Phe Asp 
            660                 665                 670         


Leu Cys Lys Glu Thr Thr Phe Glu Pro Lys Lys Met Ile Glu Gly Val 
        675                 680                 685             


Ala Tyr Glu Val Arg Ile Phe Ala Val Asn Ala Ile Gly Ile Ser Lys 
    690                 695                 700                 


Pro Ser Met Pro Ser Arg Pro Phe Val Pro Leu Ala Val Thr Ser Pro 
705                 710                 715                 720 


Pro Thr Leu Leu Thr Val Asp Ser Val Thr Asp Thr Thr Val Thr Met 
                725                 730                 735     


Arg Trp Arg Pro Pro Asp His Ile Gly Ala Ala Gly Leu Asp Gly Tyr 
            740                 745                 750         


Val Leu Glu Tyr Cys Phe Glu Gly Thr Glu Asp Trp Ile Val Ala Asn 
        755                 760                 765             


Lys Asp Leu Ile Asp Lys Thr Lys Phe Thr Ile Thr Gly Leu Pro Thr 
    770                 775                 780                 


Asp Ala Lys Ile Phe Val Arg Val Lys Ala Val Asn Ala Ala Gly Ala 
785                 790                 795                 800 


Ser Glu Pro Lys Tyr Tyr Ser Gln Pro Ile Leu Val Lys Glu Ile Ile 
                805                 810                 815     


Glu Pro Pro Lys Ile Arg Ile Pro Arg His Leu Lys Gln Thr Tyr Ile 
            820                 825                 830         


Arg Arg Val Gly Glu Ala Val Asn Leu Val Ile Pro Phe Gln Gly Lys 
        835                 840                 845             


Pro Arg Pro Glu Leu Thr Trp Lys Lys Asp Gly Ala Glu Ile Asp Lys 
    850                 855                 860                 


Asn Gln Ile Asn Ile Arg Asn Ser Glu Thr Asp Thr Ile Ile Phe Ile 
865                 870                 875                 880 


Arg Lys Ala Glu Arg Ser His Ser Gly Lys Tyr Asp Leu Gln Val Lys 
                885                 890                 895     


Val Asp Lys Phe Val Glu Thr Ala Ser Ile Asp Ile Gln Ile Ile Asp 
            900                 905                 910         


Arg Pro Gly Pro Pro Gln Ile Val Lys Ile Glu Asp Val Trp Gly Glu 
        915                 920                 925             


Asn Val Ala Leu Thr Trp Thr Pro Pro Lys Asp Asp Gly Asn Ala Ala 
    930                 935                 940                 


Ile Thr Gly Tyr Thr Ile Gln Lys Ala Asp Lys Lys Ser Met Glu Trp 
945                 950                 955                 960 


Phe Thr Val Ile Glu His Tyr His Arg Thr Ser Ala Thr Ile Thr Glu 
                965                 970                 975     


Leu Val Ile Gly Asn Glu Tyr Tyr Phe Arg Val Phe Ser Glu Asn Met 
            980                 985                 990         


Cys Gly Leu Ser Glu Asp Ala Thr  Met Thr Lys Glu Ser  Ala Val Ile 
        995                 1000                 1005             


Ala Arg  Asp Gly Lys Ile Tyr  Lys Asn Pro Val Tyr  Glu Asp Phe 
    1010                 1015                 1020             


Asp Phe  Ser Glu Ala Pro Met  Phe Thr Gln Pro Leu  Val Asn Thr 
    1025                 1030                 1035             


Tyr Ala  Ile Ala Gly Tyr Asn  Ala Thr Leu Asn Cys  Ser Val Arg 
    1040                 1045                 1050             


Gly Asn  Pro Lys Pro Lys Ile  Thr Trp Met Lys Asn  Lys Val Ala 
    1055                 1060                 1065             


Ile Val  Asp Asp Pro Arg Tyr  Arg Met Phe Ser Asn  Gln Gly Val 
    1070                 1075                 1080             


Cys Thr  Leu Glu Ile Arg Lys  Pro Ser Pro Tyr Asp  Gly Gly Thr 
    1085                 1090                 1095             


Tyr Cys  Cys Lys Ala Val Asn  Asp Leu Gly Thr Val  Glu Ile Glu 
    1100                 1105                 1110             


Cys Lys  Leu Glu Val Lys Val  Ile Ala Gln 
    1115                 1120             


<210>  84
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYBPC1_forward primer

<400>  84
tcccagctgt ccatctt                                                      17


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYCBPC1

<400>  85
cagccttgac tttggctatg                                                   20


<210>  86
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MYCBPC1_reverse primer

<400>  86
caaggaggaa cagtgaaagt tggtga                                            26


<210>  87
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  87
gccacttctc ttcccttcat tcttcgccag gctctctgct gactcaagtt cttcagttca       60

cgatcttcta gttgcagcga tgagtgcacg agtgagatca agatccagag gaagaggaga      120

tggtcaggag gctcccgatg tggttgcatt cgtggctccc ggtgaatctc agcaagagga      180

accaccaact gacaatcagg atattgaacc tggacaagag agagaaggaa cacctccgat      240

cgaagaacgt aaagtagaag gtgattgcca ggaaatggat ctggaaaaga ctcggagtga      300

gcgtggagat ggctctgatg taaaagagaa gactccacct aatcctaagc atgctaagac      360

taaagaagca ggagatgggc agccataagt taaaaagaag acaagctgaa gctacacaca      420

tggctgatgt cacattgaaa atgtgactga aaatttgaaa attctctcaa taaagtttga      480

gttttctctg aagaagtcat gcgtgtcttt tgtaaaattt attcctagga aattgacact      540

attgtaaatg gtatctttaa aaa                                              563


<210>  88
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Ser Ala Arg Val Arg Ser Arg Ser Arg Gly Arg Gly Asp Gly Gln 
1               5                   10                  15      


Glu Ala Pro Asp Val Val Ala Phe Val Ala Pro Gly Glu Ser Gln Gln 
            20                  25                  30          


Glu Glu Pro Pro Thr Asp Asn Gln Asp Ile Glu Pro Gly Gln Glu Arg 
        35                  40                  45              


Glu Gly Thr Pro Pro Ile Glu Glu Arg Lys Val Glu Gly Asp Cys Gln 
    50                  55                  60                  


Glu Met Asp Leu Glu Lys Thr Arg Ser Glu Arg Gly Asp Gly Ser Asp 
65                  70                  75                  80  


Val Lys Glu Lys Thr Pro Pro Asn Pro Lys His Ala Lys Thr Lys Glu 
                85                  90                  95      


Ala Gly Asp Gly Gln Pro 
            100         


<210>  89
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAGE4_forward primer

<400>  89
gaaggaacac ctccgat                                                      17


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAG1_reverse primer

<400>  90
catctccacg ctcactccga                                                   20


<210>  91
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAGE1 probe

<400>  91
aggtgattgc caggaaatgg atctg                                             25


<210>  92
<211>  2446
<212>  DNA
<213>  Homo sapiens

<400>  92
tccataaagg ggttgcgggg gccgcgctct cttctgggag ggcagcggcc accggcgagg       60

aacacggcgc gatgcaggtt cagtgccagc agagcccagt gctggcaggc agcgccactt      120

tggtcgccct tggggcactg gccttgtacg tcgcgaagcc ctccggctac gggaagcaca      180

cggagagcct gaagccggcg gctacccgcc tgccagcccg cgccgcctgg ttcctgcagg      240

agctgccttc cttcgcggtg cccgcgggga tcctcgcccg gcagcccctc tccctcttcg      300

ggccacctgg gacggtactt ctgggcctct tctgcctaca ttacttccac aggacatttg      360

tgtactcact gctcaatcga gggaggcctt atccagctat actcattctc agaggcactg      420

ccttctgcac tggaaatgga gtccttcaag gctactatct gatttactgt gctgaatacc      480

ctgatgggtg gtacacagac atacggttta gcttgggtgt cttcttattt attttgggaa      540

tgggaataaa cattcatagt gactatatat tgcgccagct caggaagcct ggagaaatca      600

gctacaggat tccacaaggt ggcttgttta cgtatgtttc tggagccaat ttcctcggtg      660

agatcattga atggatcggc tatgccctgg ccacttggtc cctcccagca cttgcatttg      720

catttttctc actttgtttc cttgggctgc gagcttttca ccaccatagg ttctacctca      780

agatgtttga ggactacccc aaatctcgga aagcccttat tccattcatc ttttaaagga      840

accaaattaa aaaggagcag agctcccaca atgctgatga aaactgtcaa gctgctgaaa      900

ctgtaatttt catgatataa tagtcccgta tatatgtaat agtaggtctc ctggcgttct      960

gccagctggc ctggggattc tgagtggtgt ctgcttagag tttactccta cccttccagg     1020

gacccctatc ctgatcccca actgaagctt caaaaagcca cttttccaaa tggcgacagt     1080

tgcttcttag ctattgctct gagaaagtac aaacttctcc tatgtctttc accgggcaat     1140

ccaagtacat gtggcttcat acccactccc tgtcaatgca ggacaactct gtaatcaaga     1200

attttttgac ttgaaggcag tacttataga ccttattaaa ggtatgcatt ttatacatgt     1260

aacagagtag cagaaattta aactctgaag ccacaaagac ccagagcaaa cccactccca     1320

aatgaaaacc ccagtcatgg cttccttttt cttggttaat taggaaagat gagaaattat     1380

taggtagacc ttgaatacag gagccctctc ctcatagtgc tgaaaagata ctgatgcatt     1440

gacctcattt caaatttgtg cagtgtctta gttgatgagt gcctctgttt tccagaagat     1500

ttcacaatcc ccggaaaact ggtatggcta ttcttgaagg ccaggtttta ataaccacaa     1560

acaaaaaggc atgaacctgg gtggcttatg agagagtaga gaacaacatg accctggatg     1620

gctactaaga ggatagagaa cagttttaca atagacattg caaactctca tgtttttgga     1680

aactagtggc aatatccaaa taatgagtag tgtaaaacaa agagaattaa tgatgaggtt     1740

acatgctgct tgcctccacc agatgtccac aacaatatga agtacagcag aagccccaag     1800

caactttcct ttcctggagc ttcttccttg tagttctcag gacctgttca agaaggtgtc     1860

tcctaggggc agcctgaatg cctccctcaa aggacctgca ggcagagact gaaaattgca     1920

gacagagggg cacgtctggg cagaaaacct gttttgtttg gctcagacat atagtttttt     1980

ttttttttac aaagtttcaa aaacttaaaa atcaggagat tccttcataa aactctagca     2040

ttctagtttc atttaaaaag ttggaggatc tgaacataca gagcccacat ttccacacca     2100

gaactggaac tacgtagcta gtaagcattt gagtttgcaa actcttgtga aggggtcacc     2160

ccagcatgag tgctgagata tggactctct aaggaagggg ccgaacgctt gtaattggaa     2220

tacatggaaa tatttgtctt ctcaggccta tgtttgcgga atgcattgtc aatatttagc     2280

aaactgtttt gacaaatgag caccagtggt actaagcaca gaaactcact atataagtca     2340

cataggaaac ttgaaaggtc tgaggatgat gtagattact gaaaaatgca aattgcaatc     2400

atataaataa gtgtttttgt tgttcattaa atacctttaa atcatg                    2446


<210>  93
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Gln Val Gln Cys Gln Gln Ser Pro Val Leu Ala Gly Ser Ala Thr 
1               5                   10                  15      


Leu Val Ala Leu Gly Ala Leu Ala Leu Tyr Val Ala Lys Pro Ser Gly 
            20                  25                  30          


Tyr Gly Lys His Thr Glu Ser Leu Lys Pro Ala Ala Thr Arg Leu Pro 
        35                  40                  45              


Ala Arg Ala Ala Trp Phe Leu Gln Glu Leu Pro Ser Phe Ala Val Pro 
    50                  55                  60                  


Ala Gly Ile Leu Ala Arg Gln Pro Leu Ser Leu Phe Gly Pro Pro Gly 
65                  70                  75                  80  


Thr Val Leu Leu Gly Leu Phe Cys Leu His Tyr Phe His Arg Thr Phe 
                85                  90                  95      


Val Tyr Ser Leu Leu Asn Arg Gly Arg Pro Tyr Pro Ala Ile Leu Ile 
            100                 105                 110         


Leu Arg Gly Thr Ala Phe Cys Thr Gly Asn Gly Val Leu Gln Gly Tyr 
        115                 120                 125             


Tyr Leu Ile Tyr Cys Ala Glu Tyr Pro Asp Gly Trp Tyr Thr Asp Ile 
    130                 135                 140                 


Arg Phe Ser Leu Gly Val Phe Leu Phe Ile Leu Gly Met Gly Ile Asn 
145                 150                 155                 160 


Ile His Ser Asp Tyr Ile Leu Arg Gln Leu Arg Lys Pro Gly Glu Ile 
                165                 170                 175     


Ser Tyr Arg Ile Pro Gln Gly Gly Leu Phe Thr Tyr Val Ser Gly Ala 
            180                 185                 190         


Asn Phe Leu Gly Glu Ile Ile Glu Trp Ile Gly Tyr Ala Leu Ala Thr 
        195                 200                 205             


Trp Ser Leu Pro Ala Leu Ala Phe Ala Phe Phe Ser Leu Cys Phe Leu 
    210                 215                 220                 


Gly Leu Arg Ala Phe His His His Arg Phe Tyr Leu Lys Met Phe Glu 
225                 230                 235                 240 


Asp Tyr Pro Lys Ser Arg Lys Ala Leu Ile Pro Phe Ile Phe 
                245                 250                 


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SRD5A2_forward primer

<400>  94
ggcctcttct gcctacatta c                                                 21


<210>  95
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SRD5A2_reverse primer

<400>  95
cagtgcctct gagaatgagt atag                                              24


<210>  96
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SRD5A2

<400>  96
ctcactgctc aatcgaggga gg                                                22


<210>  97
<211>  5927
<212>  DNA
<213>  Homo sapiens

<400>  97
tcgtcggagc agacgggagt ttctcctcgg ggtcggagca ggaggcacgc ggagtgtgag       60

gccacgcatg agcggacgct aaccccctcc ccagccacaa agagtctaca tgtctagggt      120

ctagacatgt tcagctttgt ggacctccgg ctcctgctcc tcttagcggc caccgccctc      180

ctgacgcacg gccaagagga aggccaagtc gagggccaag acgaagacat cccaccaatc      240

acctgcgtac agaacggcct caggtaccat gaccgagacg tgtggaaacc cgagccctgc      300

cggatctgcg tctgcgacaa cggcaaggtg ttgtgcgatg acgtgatctg tgacgagacc      360

aagaactgcc ccggcgccga agtccccgag ggcgagtgct gtcccgtctg ccccgacggc      420

tcagagtcac ccaccgacca agaaaccacc ggcgtcgagg gacccaaggg agacactggc      480

ccccgaggcc caaggggacc cgcaggcccc cctggccgag atggcatccc tggacagcct      540

ggacttcccg gaccccccgg accccccgga cctcccggac cccctggcct cggaggaaac      600

tttgctcccc agctgtctta tggctatgat gagaaatcaa ccggaggaat ttccgtgcct      660

ggccccatgg gtccctctgg tcctcgtggt ctccctggcc cccctggtgc acctggtccc      720

caaggcttcc aaggtccccc tggtgagcct ggcgagcctg gagcttcagg tcccatgggt      780

ccccgaggtc ccccaggtcc ccctggaaag aatggagatg atggggaagc tggaaaacct      840

ggtcgtcctg gtgagcgtgg gcctcctggg cctcagggtg ctcgaggatt gcccggaaca      900

gctggcctcc ctggaatgaa gggacacaga ggtttcagtg gtttggatgg tgccaaggga      960

gatgctggtc ctgctggtcc taagggtgag cctggcagcc ctggtgaaaa tggagctcct     1020

ggtcagatgg gcccccgtgg cctgcctggt gagagaggtc gccctggagc ccctggccct     1080

gctggtgctc gtggaaatga tggtgctact ggtgctgccg ggccccctgg tcccaccggc     1140

cccgctggtc ctcctggctt ccctggtgct gttggtgcta agggtgaagc tggtccccaa     1200

gggccccgag gctctgaagg tccccagggt gtgcgtggtg agcctggccc ccctggccct     1260

gctggtgctg ctggccctgc tggaaaccct ggtgctgatg gacagcctgg tgctaaaggt     1320

gccaatggtg ctcctggtat tgctggtgct cctggcttcc ctggtgcccg aggcccctct     1380

ggaccccagg gccccggcgg ccctcctggt cccaagggta acagcggtga acctggtgct     1440

cctggcagca aaggagacac tggtgctaag ggagagcctg gccctgttgg tgttcaagga     1500

ccccctggcc ctgctggaga ggaaggaaag cgaggagctc gaggtgaacc cggacccact     1560

ggcctgcccg gaccccctgg cgagcgtggt ggacctggta gccgtggttt ccctggcgca     1620

gatggtgttg ctggtcccaa gggtcccgct ggtgaacgtg gttctcctgg ccctgctggc     1680

cccaaaggat ctcctggtga agctggtcgt cccggtgaag ctggtctgcc tggtgccaag     1740

ggtctgactg gaagccctgg cagccctggt cctgatggca aaactggccc ccctggtccc     1800

gccggtcaag atggtcgccc cggaccccca ggcccacctg gtgcccgtgg tcaggctggt     1860

gtgatgggat tccctggacc taaaggtgct gctggagagc ccggcaaggc tggagagcga     1920

ggtgttcccg gaccccctgg cgctgtcggt cctgctggca aagatggaga ggctggagct     1980

cagggacccc ctggccctgc tggtcccgct ggcgagagag gtgaacaagg ccctgctggc     2040

tcccccggat tccagggtct ccctggtcct gctggtcctc caggtgaagc aggcaaacct     2100

ggtgaacagg gtgttcctgg agaccttggc gcccctggcc cctctggagc aagaggcgag     2160

agaggtttcc ctggcgagcg tggtgtgcaa ggtccccctg gtcctgctgg tccccgaggg     2220

gccaacggtg ctcccggcaa cgatggtgct aagggtgatg ctggtgcccc tggagctccc     2280

ggtagccagg gcgcccctgg ccttcaggga atgcctggtg aacgtggtgc agctggtctt     2340

ccagggccta agggtgacag aggtgatgct ggtcccaaag gtgctgatgg ctctcctggc     2400

aaagatggcg tccgtggtct gactggcccc attggtcctc ctggccctgc tggtgcccct     2460

ggtgacaagg gtgaaagtgg tcccagcggc cctgctggtc ccactggagc tcgtggtgcc     2520

cccggagacc gtggtgagcc tggtcccccc ggccctgctg gctttgctgg cccccctggt     2580

gctgacggcc aacctggtgc taaaggcgaa cctggtgatg ctggtgctaa aggcgatgct     2640

ggtccccctg gccctgccgg acccgctgga ccccctggcc ccattggtaa tgttggtgct     2700

cctggagcca aaggtgctcg cggcagcgct ggtccccctg gtgctactgg tttccctggt     2760

gctgctggcc gagtcggtcc tcctggcccc tctggaaatg ctggaccccc tggccctcct     2820

ggtcctgctg gcaaagaagg cggcaaaggt ccccgtggtg agactggccc tgctggacgt     2880

cctggtgaag ttggtccccc tggtccccct ggccctgctg gcgagaaagg atcccctggt     2940

gctgatggtc ctgctggtgc tcctggtact cccgggcctc aaggtattgc tggacagcgt     3000

ggtgtggtcg gcctgcctgg tcagagagga gagagaggct tccctggtct tcctggcccc     3060

tctggtgaac ctggcaaaca aggtccctct ggagcaagtg gtgaacgtgg tccccctggt     3120

cccatgggcc cccctggatt ggctggaccc cctggtgaat ctggacgtga gggggctcct     3180

ggtgccgaag gttcccctgg acgagacggt tctcctggcg ccaagggtga ccgtggtgag     3240

accggccccg ctggaccccc tggtgctcct ggtgctcctg gtgcccctgg ccccgttggc     3300

cctgctggca agagtggtga tcgtggtgag actggtcctg ctggtcccgc cggtcctgtc     3360

ggccctgttg gcgcccgtgg ccccgccgga ccccaaggcc cccgtggtga caagggtgag     3420

acaggcgaac agggcgacag aggcataaag ggtcaccgtg gcttctctgg cctccagggt     3480

ccccctggcc ctcctggctc tcctggtgaa caaggtccct ctggagcctc tggtcctgct     3540

ggtccccgag gtccccctgg ctctgctggt gctcctggca aagatggact caacggtctc     3600

cctggcccca ttgggccccc tggtcctcgc ggtcgcactg gtgatgctgg tcctgttggt     3660

ccccccggcc ctcctggacc tcctggtccc cctggtcctc ccagcgctgg tttcgacttc     3720

agcttcctgc cccagccacc tcaagagaag gctcacgatg gtggccgcta ctaccgggct     3780

gatgatgcca atgtggttcg tgaccgtgac ctcgaggtgg acaccaccct caagagcctg     3840

agccagcaga tcgagaacat ccggagccca gagggcagcc gcaagaaccc cgcccgcacc     3900

tgccgtgacc tcaagatgtg ccactctgac tggaagagtg gagagtactg gattgacccc     3960

aaccaaggct gcaacctgga tgccatcaaa gtcttctgca acatggagac tggtgagacc     4020

tgcgtgtacc ccactcagcc cagtgtggcc cagaagaact ggtacatcag caagaacccc     4080

aaggacaaga ggcatgtctg gttcggcgag agcatgaccg atggattcca gttcgagtat     4140

ggcggccagg gctccgaccc tgccgatgtg gccatccagc tgaccttcct gcgcctgatg     4200

tccaccgagg cctcccagaa catcacctac cactgcaaga acagcgtggc ctacatggac     4260

cagcagactg gcaacctcaa gaaggccctg ctcctccagg gctccaacga gatcgagatc     4320

cgcgccgagg gcaacagccg cttcacctac agcgtcactg tcgatggctg cacgagtcac     4380

accggagcct ggggcaagac agtgattgaa tacaaaacca ccaagacctc ccgcctgccc     4440

atcatcgatg tggccccctt ggacgttggt gccccagacc aggaattcgg cttcgacgtt     4500

ggccctgtct gcttcctgta aactccctcc atcccaacct ggctccctcc cacccaacca     4560

actttccccc caacccggaa acagacaagc aacccaaact gaaccccctc aaaagccaaa     4620

aaatgggaga caatttcaca tggactttgg aaaatatttt tttcctttgc attcatctct     4680

caaacttagt ttttatcttt gaccaaccga acatgaccaa aaaccaaaag tgcattcaac     4740

cttaccaaaa aaaaaaaaaa aaaaagaata aataaataac tttttaaaaa aggaagcttg     4800

gtccacttgc ttgaagaccc atgcgggggt aagtcccttt ctgcccgttg ggcttatgaa     4860

accccaatgc tgccctttct gctcctttct ccacaccccc cttggggcct cccctccact     4920

ccttcccaaa tctgtctccc cagaagacac aggaaacaat gtattgtctg cccagcaatc     4980

aaaggcaatg ctcaaacacc caagtggccc ccaccctcag cccgctcctg cccgcccagc     5040

acccccaggc cctgggggac ctggggttct cagactgcca aagaagcctt gccatctggc     5100

gctcccatgg ctcttgcaac atctcccctt cgtttttgag ggggtcatgc cgggggagcc     5160

accagcccct cactgggttc ggaggagagt caggaagggc cacgacaaag cagaaacatc     5220

ggatttgggg aacgcgtgtc aatcccttgt gccgcagggc tgggcgggag agactgttct     5280

gttccttgtg taactgtgtt gctgaaagac tacctcgttc ttgtcttgat gtgtcaccgg     5340

ggcaactgcc tgggggcggg gatgggggca gggtggaagc ggctccccat tttataccaa     5400

aggtgctaca tctatgtgat gggtggggtg gggagggaat cactggtgct atagaaattg     5460

agatgccccc ccaggccagc aaatgttcct ttttgttcaa agtctatttt tattccttga     5520

tatttttctt tttttttttt tttttttgtg gatggggact tgtgaatttt tctaaaggtg     5580

ctatttaaca tgggaggaga gcgtgtgcgg ctccagccca gcccgctgct cactttccac     5640

cctctctcca cctgcctctg gcttctcagg cctctgctct ccgacctctc tcctctgaaa     5700

ccctcctcca cagctgcagc ccatcctccc ggctccctcc tagtctgtcc tgcgtcctct     5760

gtccccgggt ttcagagaca acttcccaaa gcacaaagca gtttttcccc ctaggggtgg     5820

gaggaagcaa aagactctgt acctattttg tatgtgtata ataatttgag atgtttttaa     5880

ttattttgat tgctggaata aagcatgtgg aaatgaccca aacataa                   5927


<210>  98
<211>  1464
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly Gln Glu Glu Gly Gln Val Glu Gly Gln Asp 
            20                  25                  30          


Glu Asp Ile Pro Pro Ile Thr Cys Val Gln Asn Gly Leu Arg Tyr His 
        35                  40                  45              


Asp Arg Asp Val Trp Lys Pro Glu Pro Cys Arg Ile Cys Val Cys Asp 
    50                  55                  60                  


Asn Gly Lys Val Leu Cys Asp Asp Val Ile Cys Asp Glu Thr Lys Asn 
65                  70                  75                  80  


Cys Pro Gly Ala Glu Val Pro Glu Gly Glu Cys Cys Pro Val Cys Pro 
                85                  90                  95      


Asp Gly Ser Glu Ser Pro Thr Asp Gln Glu Thr Thr Gly Val Glu Gly 
            100                 105                 110         


Pro Lys Gly Asp Thr Gly Pro Arg Gly Pro Arg Gly Pro Ala Gly Pro 
        115                 120                 125             


Pro Gly Arg Asp Gly Ile Pro Gly Gln Pro Gly Leu Pro Gly Pro Pro 
    130                 135                 140                 


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Leu Gly Gly Asn Phe Ala 
145                 150                 155                 160 


Pro Gln Leu Ser Tyr Gly Tyr Asp Glu Lys Ser Thr Gly Gly Ile Ser 
                165                 170                 175     


Val Pro Gly Pro Met Gly Pro Ser Gly Pro Arg Gly Leu Pro Gly Pro 
            180                 185                 190         


Pro Gly Ala Pro Gly Pro Gln Gly Phe Gln Gly Pro Pro Gly Glu Pro 
        195                 200                 205             


Gly Glu Pro Gly Ala Ser Gly Pro Met Gly Pro Arg Gly Pro Pro Gly 
    210                 215                 220                 


Pro Pro Gly Lys Asn Gly Asp Asp Gly Glu Ala Gly Lys Pro Gly Arg 
225                 230                 235                 240 


Pro Gly Glu Arg Gly Pro Pro Gly Pro Gln Gly Ala Arg Gly Leu Pro 
                245                 250                 255     


Gly Thr Ala Gly Leu Pro Gly Met Lys Gly His Arg Gly Phe Ser Gly 
            260                 265                 270         


Leu Asp Gly Ala Lys Gly Asp Ala Gly Pro Ala Gly Pro Lys Gly Glu 
        275                 280                 285             


Pro Gly Ser Pro Gly Glu Asn Gly Ala Pro Gly Gln Met Gly Pro Arg 
    290                 295                 300                 


Gly Leu Pro Gly Glu Arg Gly Arg Pro Gly Ala Pro Gly Pro Ala Gly 
305                 310                 315                 320 


Ala Arg Gly Asn Asp Gly Ala Thr Gly Ala Ala Gly Pro Pro Gly Pro 
                325                 330                 335     


Thr Gly Pro Ala Gly Pro Pro Gly Phe Pro Gly Ala Val Gly Ala Lys 
            340                 345                 350         


Gly Glu Ala Gly Pro Gln Gly Pro Arg Gly Ser Glu Gly Pro Gln Gly 
        355                 360                 365             


Val Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Ala Ala Gly Pro 
    370                 375                 380                 


Ala Gly Asn Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Ala Asn 
385                 390                 395                 400 


Gly Ala Pro Gly Ile Ala Gly Ala Pro Gly Phe Pro Gly Ala Arg Gly 
                405                 410                 415     


Pro Ser Gly Pro Gln Gly Pro Gly Gly Pro Pro Gly Pro Lys Gly Asn 
            420                 425                 430         


Ser Gly Glu Pro Gly Ala Pro Gly Ser Lys Gly Asp Thr Gly Ala Lys 
        435                 440                 445             


Gly Glu Pro Gly Pro Val Gly Val Gln Gly Pro Pro Gly Pro Ala Gly 
    450                 455                 460                 


Glu Glu Gly Lys Arg Gly Ala Arg Gly Glu Pro Gly Pro Thr Gly Leu 
465                 470                 475                 480 


Pro Gly Pro Pro Gly Glu Arg Gly Gly Pro Gly Ser Arg Gly Phe Pro 
                485                 490                 495     


Gly Ala Asp Gly Val Ala Gly Pro Lys Gly Pro Ala Gly Glu Arg Gly 
            500                 505                 510         


Ser Pro Gly Pro Ala Gly Pro Lys Gly Ser Pro Gly Glu Ala Gly Arg 
        515                 520                 525             


Pro Gly Glu Ala Gly Leu Pro Gly Ala Lys Gly Leu Thr Gly Ser Pro 
    530                 535                 540                 


Gly Ser Pro Gly Pro Asp Gly Lys Thr Gly Pro Pro Gly Pro Ala Gly 
545                 550                 555                 560 


Gln Asp Gly Arg Pro Gly Pro Pro Gly Pro Pro Gly Ala Arg Gly Gln 
                565                 570                 575     


Ala Gly Val Met Gly Phe Pro Gly Pro Lys Gly Ala Ala Gly Glu Pro 
            580                 585                 590         


Gly Lys Ala Gly Glu Arg Gly Val Pro Gly Pro Pro Gly Ala Val Gly 
        595                 600                 605             


Pro Ala Gly Lys Asp Gly Glu Ala Gly Ala Gln Gly Pro Pro Gly Pro 
    610                 615                 620                 


Ala Gly Pro Ala Gly Glu Arg Gly Glu Gln Gly Pro Ala Gly Ser Pro 
625                 630                 635                 640 


Gly Phe Gln Gly Leu Pro Gly Pro Ala Gly Pro Pro Gly Glu Ala Gly 
                645                 650                 655     


Lys Pro Gly Glu Gln Gly Val Pro Gly Asp Leu Gly Ala Pro Gly Pro 
            660                 665                 670         


Ser Gly Ala Arg Gly Glu Arg Gly Phe Pro Gly Glu Arg Gly Val Gln 
        675                 680                 685             


Gly Pro Pro Gly Pro Ala Gly Pro Arg Gly Ala Asn Gly Ala Pro Gly 
    690                 695                 700                 


Asn Asp Gly Ala Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly Ser 
705                 710                 715                 720 


Gln Gly Ala Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Ala Ala 
                725                 730                 735     


Gly Leu Pro Gly Pro Lys Gly Asp Arg Gly Asp Ala Gly Pro Lys Gly 
            740                 745                 750         


Ala Asp Gly Ser Pro Gly Lys Asp Gly Val Arg Gly Leu Thr Gly Pro 
        755                 760                 765             


Ile Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Asp Lys Gly Glu Ser 
    770                 775                 780                 


Gly Pro Ser Gly Pro Ala Gly Pro Thr Gly Ala Arg Gly Ala Pro Gly 
785                 790                 795                 800 


Asp Arg Gly Glu Pro Gly Pro Pro Gly Pro Ala Gly Phe Ala Gly Pro 
                805                 810                 815     


Pro Gly Ala Asp Gly Gln Pro Gly Ala Lys Gly Glu Pro Gly Asp Ala 
            820                 825                 830         


Gly Ala Lys Gly Asp Ala Gly Pro Pro Gly Pro Ala Gly Pro Ala Gly 
        835                 840                 845             


Pro Pro Gly Pro Ile Gly Asn Val Gly Ala Pro Gly Ala Lys Gly Ala 
    850                 855                 860                 


Arg Gly Ser Ala Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly Ala Ala 
865                 870                 875                 880 


Gly Arg Val Gly Pro Pro Gly Pro Ser Gly Asn Ala Gly Pro Pro Gly 
                885                 890                 895     


Pro Pro Gly Pro Ala Gly Lys Glu Gly Gly Lys Gly Pro Arg Gly Glu 
            900                 905                 910         


Thr Gly Pro Ala Gly Arg Pro Gly Glu Val Gly Pro Pro Gly Pro Pro 
        915                 920                 925             


Gly Pro Ala Gly Glu Lys Gly Ser Pro Gly Ala Asp Gly Pro Ala Gly 
    930                 935                 940                 


Ala Pro Gly Thr Pro Gly Pro Gln Gly Ile Ala Gly Gln Arg Gly Val 
945                 950                 955                 960 


Val Gly Leu Pro Gly Gln Arg Gly Glu Arg Gly Phe Pro Gly Leu Pro 
                965                 970                 975     


Gly Pro Ser Gly Glu Pro Gly Lys Gln Gly Pro Ser Gly Ala Ser Gly 
            980                 985                 990         


Glu Arg Gly Pro Pro Gly Pro Met  Gly Pro Pro Gly Leu  Ala Gly Pro 
        995                 1000                 1005             


Pro Gly  Glu Ser Gly Arg Glu  Gly Ala Pro Gly Ala  Glu Gly Ser 
    1010                 1015                 1020             


Pro Gly  Arg Asp Gly Ser Pro  Gly Ala Lys Gly Asp  Arg Gly Glu 
    1025                 1030                 1035             


Thr Gly  Pro Ala Gly Pro Pro  Gly Ala Pro Gly Ala  Pro Gly Ala 
    1040                 1045                 1050             


Pro Gly  Pro Val Gly Pro Ala  Gly Lys Ser Gly Asp  Arg Gly Glu 
    1055                 1060                 1065             


Thr Gly  Pro Ala Gly Pro Ala  Gly Pro Val Gly Pro  Val Gly Ala 
    1070                 1075                 1080             


Arg Gly  Pro Ala Gly Pro Gln  Gly Pro Arg Gly Asp  Lys Gly Glu 
    1085                 1090                 1095             


Thr Gly  Glu Gln Gly Asp Arg  Gly Ile Lys Gly His  Arg Gly Phe 
    1100                 1105                 1110             


Ser Gly  Leu Gln Gly Pro Pro  Gly Pro Pro Gly Ser  Pro Gly Glu 
    1115                 1120                 1125             


Gln Gly  Pro Ser Gly Ala Ser  Gly Pro Ala Gly Pro  Arg Gly Pro 
    1130                 1135                 1140             


Pro Gly  Ser Ala Gly Ala Pro  Gly Lys Asp Gly Leu  Asn Gly Leu 
    1145                 1150                 1155             


Pro Gly  Pro Ile Gly Pro Pro  Gly Pro Arg Gly Arg  Thr Gly Asp 
    1160                 1165                 1170             


Ala Gly  Pro Val Gly Pro Pro  Gly Pro Pro Gly Pro  Pro Gly Pro 
    1175                 1180                 1185             


Pro Gly  Pro Pro Ser Ala Gly  Phe Asp Phe Ser Phe  Leu Pro Gln 
    1190                 1195                 1200             


Pro Pro  Gln Glu Lys Ala His  Asp Gly Gly Arg Tyr  Tyr Arg Ala 
    1205                 1210                 1215             


Asp Asp  Ala Asn Val Val Arg  Asp Arg Asp Leu Glu  Val Asp Thr 
    1220                 1225                 1230             


Thr Leu  Lys Ser Leu Ser Gln  Gln Ile Glu Asn Ile  Arg Ser Pro 
    1235                 1240                 1245             


Glu Gly  Ser Arg Lys Asn Pro  Ala Arg Thr Cys Arg  Asp Leu Lys 
    1250                 1255                 1260             


Met Cys  His Ser Asp Trp Lys  Ser Gly Glu Tyr Trp  Ile Asp Pro 
    1265                 1270                 1275             


Asn Gln  Gly Cys Asn Leu Asp  Ala Ile Lys Val Phe  Cys Asn Met 
    1280                 1285                 1290             


Glu Thr  Gly Glu Thr Cys Val  Tyr Pro Thr Gln Pro  Ser Val Ala 
    1295                 1300                 1305             


Gln Lys  Asn Trp Tyr Ile Ser  Lys Asn Pro Lys Asp  Lys Arg His 
    1310                 1315                 1320             


Val Trp  Phe Gly Glu Ser Met  Thr Asp Gly Phe Gln  Phe Glu Tyr 
    1325                 1330                 1335             


Gly Gly  Gln Gly Ser Asp Pro  Ala Asp Val Ala Ile  Gln Leu Thr 
    1340                 1345                 1350             


Phe Leu  Arg Leu Met Ser Thr  Glu Ala Ser Gln Asn  Ile Thr Tyr 
    1355                 1360                 1365             


His Cys  Lys Asn Ser Val Ala  Tyr Met Asp Gln Gln  Thr Gly Asn 
    1370                 1375                 1380             


Leu Lys  Lys Ala Leu Leu Leu  Gln Gly Ser Asn Glu  Ile Glu Ile 
    1385                 1390                 1395             


Arg Ala  Glu Gly Asn Ser Arg  Phe Thr Tyr Ser Val  Thr Val Asp 
    1400                 1405                 1410             


Gly Cys  Thr Ser His Thr Gly  Ala Trp Gly Lys Thr  Val Ile Glu 
    1415                 1420                 1425             


Tyr Lys  Thr Thr Lys Thr Ser  Arg Leu Pro Ile Ile  Asp Val Ala 
    1430                 1435                 1440             


Pro Leu  Asp Val Gly Ala Pro  Asp Gln Glu Phe Gly  Phe Asp Val 
    1445                 1450                 1455             


Gly Pro  Val Cys Phe Leu 
    1460                 


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL1A1_forward primer

<400>  99
gaagacatcc caccaatcac                                                   20


<210>  100
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL1A1_reverse primer

<400>  100
cgggtttcca cacgtctc                                                     18


<210>  101
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL1A1 probe

<400>  101
ctgcgtacag aacggcctca ggta                                              24


<210>  102
<211>  5490
<212>  DNA
<213>  Homo sapiens

<400>  102
ggctgagttt tatgacgggc ccggtgctga agggcaggga acaacttgat ggtgctactt       60

tgaactgctt ttcttttctc ctttttgcac aaagagtctc atgtctgata tttagacatg      120

atgagctttg tgcaaaaggg gagctggcta cttctcgctc tgcttcatcc cactattatt      180

ttggcacaac aggaagctgt tgaaggagga tgttcccatc ttggtcagtc ctatgcggat      240

agagatgtct ggaagccaga accatgccaa atatgtgtct gtgactcagg atccgttctc      300

tgcgatgaca taatatgtga cgatcaagaa ttagactgcc ccaacccaga aattccattt      360

ggagaatgtt gtgcagtttg cccacagcct ccaactgctc ctactcgccc tcctaatggt      420

caaggacctc aaggccccaa gggagatcca ggccctcctg gtattcctgg gagaaatggt      480

gaccctggta ttccaggaca accagggtcc cctggttctc ctggcccccc tggaatctgt      540

gaatcatgcc ctactggtcc tcagaactat tctccccagt atgattcata tgatgtcaag      600

tctggagtag cagtaggagg actcgcaggc tatcctggac cagctggccc cccaggccct      660

cccggtcccc ctggtacatc tggtcatcct ggttcccctg gatctccagg ataccaagga      720

ccccctggtg aacctgggca agctggtcct tcaggccctc caggacctcc tggtgctata      780

ggtccatctg gtcctgctgg aaaagatgga gaatcaggta gacccggacg acctggagag      840

cgaggattgc ctggacctcc aggtatcaaa ggtccagctg ggatacctgg attccctggt      900

atgaaaggac acagaggctt cgatggacga aatggagaaa agggtgaaac aggtgctcct      960

ggattaaagg gtgaaaatgg tcttccaggc gaaaatggag ctcctggacc catgggtcca     1020

agaggggctc ctggtgagcg aggacggcca ggacttcctg gggctgcagg tgctcggggt     1080

aatgacggtg ctcgaggcag tgatggtcaa ccaggccctc ctggtcctcc tggaactgcc     1140

ggattccctg gatcccctgg tgctaagggt gaagttggac ctgcagggtc tcctggttca     1200

aatggtgccc ctggacaaag aggagaacct ggacctcagg gacacgctgg tgctcaaggt     1260

cctcctggcc ctcctgggat taatggtagt cctggtggta aaggcgaaat gggtcccgct     1320

ggcattcctg gagctcctgg actgatggga gcccggggtc ctccaggacc agccggtgct     1380

aatggtgctc ctggactgcg aggtggtgca ggtgagcctg gtaagaatgg tgccaaagga     1440

gagcccggac cacgtggtga acgcggtgag gctggtattc caggtgttcc aggagctaaa     1500

ggcgaagatg gcaaggatgg atcacctgga gaacctggtg caaatgggct tccaggagct     1560

gcaggagaaa ggggtgcccc tgggttccga ggacctgctg gaccaaatgg catcccagga     1620

gaaaagggtc ctgctggaga gcgtggtgct ccaggccctg cagggcccag aggagctgct     1680

ggagaacctg gcagagatgg cgtccctgga ggtccaggaa tgaggggcat gcccggaagt     1740

ccaggaggac caggaagtga tgggaaacca gggcctcccg gaagtcaagg agaaagtggt     1800

cgaccaggtc ctcctgggcc atctggtccc cgaggtcagc ctggtgtcat gggcttcccc     1860

ggtcctaaag gaaatgatgg tgctcctggt aagaatggag aacgaggtgg ccctggagga     1920

cctggccctc agggtcctcc tggaaagaat ggtgaaactg gacctcaggg acccccaggg     1980

cctactgggc ctggtggtga caaaggagac acaggacccc ctggtccaca aggattacaa     2040

ggcttgcctg gtacaggtgg tcctccagga gaaaatggaa aacctgggga accaggtcca     2100

aagggtgatg ccggtgcacc tggagctcca ggaggcaagg gtgatgctgg tgcccctggt     2160

gaacgtggac ctcctggatt ggcaggggcc ccaggactta gaggtggagc tggtccccct     2220

ggtcccgaag gaggaaaggg tgctgctggt cctcctgggc cacctggtgc tgctggtact     2280

cctggtctgc aaggaatgcc tggagaaaga ggaggtcttg gaagtcctgg tccaaagggt     2340

gacaagggtg aaccaggcgg tccaggtgct gatggtgtcc cagggaaaga tggcccaagg     2400

ggtcctactg gtcctattgg tcctcctggc ccagctggcc agcctggaga taagggtgaa     2460

ggtggtgccc ccggacttcc aggtatagct ggacctcgtg gtagccctgg tgagagaggt     2520

gaaactggcc ctccaggacc tgctggtttc cctggtgctc ctggacagaa tggtgaacct     2580

ggtggtaaag gagaaagagg ggctccgggt gagaaaggtg aaggaggccc tcctggagtt     2640

gcaggacccc ctggaggttc tggacctgct ggtcctcctg gtccccaagg tgtcaaaggt     2700

gaacgtggca gtcctggtgg acctggtgct gctggcttcc ctggtgctcg tggtcttcct     2760

ggtcctcctg gtagtaatgg taacccagga cccccaggtc ccagcggttc tccaggcaag     2820

gatgggcccc caggtcctgc gggtaacact ggtgctcctg gcagccctgg agtgtctgga     2880

ccaaaaggtg atgctggcca accaggagag aagggatcgc ctggtgccca gggcccacca     2940

ggagctccag gcccacttgg gattgctggg atcactggag cacggggtct tgcaggacca     3000

ccaggcatgc caggtcctag gggaagccct ggccctcagg gtgtcaaggg tgaaagtggg     3060

aaaccaggag ctaacggtct cagtggagaa cgtggtcccc ctggacccca gggtcttcct     3120

ggtctggctg gtacagctgg tgaacctgga agagatggaa accctggatc agatggtctt     3180

ccaggccgag atggatctcc tggtggcaag ggtgatcgtg gtgaaaatgg ctctcctggt     3240

gcccctggcg ctcctggtca tccaggccca cctggtcctg tcggtccagc tggaaagagt     3300

ggtgacagag gagaaagtgg ccctgctggc cctgctggtg ctcccggtcc tgctggttcc     3360

cgaggtgctc ctggtcctca aggcccacgt ggtgacaaag gtgaaacagg tgaacgtgga     3420

gctgctggca tcaaaggaca tcgaggattc cctggtaatc caggtgcccc aggttctcca     3480

ggccctgctg gtcagcaggg tgcaatcggc agtccaggac ctgcaggccc cagaggacct     3540

gttggaccca gtggacctcc tggcaaagat ggaaccagtg gacatccagg tcccattgga     3600

ccaccagggc ctcgaggtaa cagaggtgaa agaggatctg agggctcccc aggccaccca     3660

gggcaaccag gccctcctgg acctcctggt gcccctggtc cttgctgtgg tggtgttgga     3720

gccgctgcca ttgctgggat tggaggtgaa aaagctggcg gttttgcccc gtattatgga     3780

gatgaaccaa tggatttcaa aatcaacacc gatgagatta tgacttcact caagtctgtt     3840

aatggacaaa tagaaagcct cattagtcct gatggttctc gtaaaaaccc cgctagaaac     3900

tgcagagacc tgaaattctg ccatcctgaa ctcaagagtg gagaatactg ggttgaccct     3960

aaccaaggat gcaaattgga tgctatcaag gtattctgta atatggaaac tggggaaaca     4020

tgcataagtg ccaatccttt gaatgttcca cggaaacact ggtggacaga ttctagtgct     4080

gagaagaaac acgtttggtt tggagagtcc atggatggtg gttttcagtt tagctacggc     4140

aatcctgaac ttcctgaaga tgtccttgat gtgcagctgg cattccttcg acttctctcc     4200

agccgagctt cccagaacat cacatatcac tgcaaaaata gcattgcata catggatcag     4260

gccagtggaa atgtaaagaa ggccctgaag ctgatggggt caaatgaagg tgaattcaag     4320

gctgaaggaa atagcaaatt cacctacaca gttctggagg atggttgcac gaaacacact     4380

ggggaatgga gcaaaacagt ctttgaatat cgaacacgca aggctgtgag actacctatt     4440

gtagatattg caccctatga cattggtggt cctgatcaag aatttggtgt ggacgttggc     4500

cctgtttgct ttttataaac caaactctat ctgaaatccc aacaaaaaaa atttaactcc     4560

atatgtgttc ctcttgttct aatcttgtca accagtgcaa gtgaccgaca aaattccagt     4620

tatttatttc caaaatgttt ggaaacagta taatttgaca aagaaaaatg atacttctct     4680

ttttttgctg ttccaccaaa tacaattcaa atgctttttg ttttattttt ttaccaattc     4740

caatttcaaa atgtctcaat ggtgctataa taaataaact tcaacactct ttatgataac     4800

aacactgtgt tatattcttt gaatcctagc ccatctgcag agcaatgact gtgctcacca     4860

gtaaaagata acctttcttt ctgaaatagt caaatacgaa attagaaaag ccctccctat     4920

tttaactacc tcaactggtc agaaacacag attgtattct atgagtccca gaagatgaaa     4980

aaaattttat acgttgataa aacttataaa tttcattgat taatctcctg gaagattggt     5040

ttaaaaagaa aagtgtaatg caagaattta aagaaatatt tttaaagcca caattatttt     5100

aatattggat atcaactgct tgtaaaggtg ctcctctttt ttcttgtcat tgctggtcaa     5160

gattactaat atttgggaag gctttaaaga cgcatgttat ggtgctaatg tactttcact     5220

tttaaactct agatcagaat tgttgacttg cattcagaac ataaatgcac aaaatctgta     5280

catgtctccc atcagaaaga ttcattggca tgccacaggg gattctcctc cttcatcctg     5340

taaaggtcaa caataaaaac caaattatgg ggctgctttt gtcacactag catagagaat     5400

gtgttgaaat ttaactttgt aagcttgtat gtggttgttg atcttttttt tccttacaga     5460

cacccataat aaaatatcat attaaaattc                                      5490


<210>  103
<211>  1466
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Met Ser Phe Val Gln Lys Gly Ser Trp Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


His Pro Thr Ile Ile Leu Ala Gln Gln Glu Ala Val Glu Gly Gly Cys 
            20                  25                  30          


Ser His Leu Gly Gln Ser Tyr Ala Asp Arg Asp Val Trp Lys Pro Glu 
        35                  40                  45              


Pro Cys Gln Ile Cys Val Cys Asp Ser Gly Ser Val Leu Cys Asp Asp 
    50                  55                  60                  


Ile Ile Cys Asp Asp Gln Glu Leu Asp Cys Pro Asn Pro Glu Ile Pro 
65                  70                  75                  80  


Phe Gly Glu Cys Cys Ala Val Cys Pro Gln Pro Pro Thr Ala Pro Thr 
                85                  90                  95      


Arg Pro Pro Asn Gly Gln Gly Pro Gln Gly Pro Lys Gly Asp Pro Gly 
            100                 105                 110         


Pro Pro Gly Ile Pro Gly Arg Asn Gly Asp Pro Gly Ile Pro Gly Gln 
        115                 120                 125             


Pro Gly Ser Pro Gly Ser Pro Gly Pro Pro Gly Ile Cys Glu Ser Cys 
    130                 135                 140                 


Pro Thr Gly Pro Gln Asn Tyr Ser Pro Gln Tyr Asp Ser Tyr Asp Val 
145                 150                 155                 160 


Lys Ser Gly Val Ala Val Gly Gly Leu Ala Gly Tyr Pro Gly Pro Ala 
                165                 170                 175     


Gly Pro Pro Gly Pro Pro Gly Pro Pro Gly Thr Ser Gly His Pro Gly 
            180                 185                 190         


Ser Pro Gly Ser Pro Gly Tyr Gln Gly Pro Pro Gly Glu Pro Gly Gln 
        195                 200                 205             


Ala Gly Pro Ser Gly Pro Pro Gly Pro Pro Gly Ala Ile Gly Pro Ser 
    210                 215                 220                 


Gly Pro Ala Gly Lys Asp Gly Glu Ser Gly Arg Pro Gly Arg Pro Gly 
225                 230                 235                 240 


Glu Arg Gly Leu Pro Gly Pro Pro Gly Ile Lys Gly Pro Ala Gly Ile 
                245                 250                 255     


Pro Gly Phe Pro Gly Met Lys Gly His Arg Gly Phe Asp Gly Arg Asn 
            260                 265                 270         


Gly Glu Lys Gly Glu Thr Gly Ala Pro Gly Leu Lys Gly Glu Asn Gly 
        275                 280                 285             


Leu Pro Gly Glu Asn Gly Ala Pro Gly Pro Met Gly Pro Arg Gly Ala 
    290                 295                 300                 


Pro Gly Glu Arg Gly Arg Pro Gly Leu Pro Gly Ala Ala Gly Ala Arg 
305                 310                 315                 320 


Gly Asn Asp Gly Ala Arg Gly Ser Asp Gly Gln Pro Gly Pro Pro Gly 
                325                 330                 335     


Pro Pro Gly Thr Ala Gly Phe Pro Gly Ser Pro Gly Ala Lys Gly Glu 
            340                 345                 350         


Val Gly Pro Ala Gly Ser Pro Gly Ser Asn Gly Ala Pro Gly Gln Arg 
        355                 360                 365             


Gly Glu Pro Gly Pro Gln Gly His Ala Gly Ala Gln Gly Pro Pro Gly 
    370                 375                 380                 


Pro Pro Gly Ile Asn Gly Ser Pro Gly Gly Lys Gly Glu Met Gly Pro 
385                 390                 395                 400 


Ala Gly Ile Pro Gly Ala Pro Gly Leu Met Gly Ala Arg Gly Pro Pro 
                405                 410                 415     


Gly Pro Ala Gly Ala Asn Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly 
            420                 425                 430         


Glu Pro Gly Lys Asn Gly Ala Lys Gly Glu Pro Gly Pro Arg Gly Glu 
        435                 440                 445             


Arg Gly Glu Ala Gly Ile Pro Gly Val Pro Gly Ala Lys Gly Glu Asp 
    450                 455                 460                 


Gly Lys Asp Gly Ser Pro Gly Glu Pro Gly Ala Asn Gly Leu Pro Gly 
465                 470                 475                 480 


Ala Ala Gly Glu Arg Gly Ala Pro Gly Phe Arg Gly Pro Ala Gly Pro 
                485                 490                 495     


Asn Gly Ile Pro Gly Glu Lys Gly Pro Ala Gly Glu Arg Gly Ala Pro 
            500                 505                 510         


Gly Pro Ala Gly Pro Arg Gly Ala Ala Gly Glu Pro Gly Arg Asp Gly 
        515                 520                 525             


Val Pro Gly Gly Pro Gly Met Arg Gly Met Pro Gly Ser Pro Gly Gly 
    530                 535                 540                 


Pro Gly Ser Asp Gly Lys Pro Gly Pro Pro Gly Ser Gln Gly Glu Ser 
545                 550                 555                 560 


Gly Arg Pro Gly Pro Pro Gly Pro Ser Gly Pro Arg Gly Gln Pro Gly 
                565                 570                 575     


Val Met Gly Phe Pro Gly Pro Lys Gly Asn Asp Gly Ala Pro Gly Lys 
            580                 585                 590         


Asn Gly Glu Arg Gly Gly Pro Gly Gly Pro Gly Pro Gln Gly Pro Pro 
        595                 600                 605             


Gly Lys Asn Gly Glu Thr Gly Pro Gln Gly Pro Pro Gly Pro Thr Gly 
    610                 615                 620                 


Pro Gly Gly Asp Lys Gly Asp Thr Gly Pro Pro Gly Pro Gln Gly Leu 
625                 630                 635                 640 


Gln Gly Leu Pro Gly Thr Gly Gly Pro Pro Gly Glu Asn Gly Lys Pro 
                645                 650                 655     


Gly Glu Pro Gly Pro Lys Gly Asp Ala Gly Ala Pro Gly Ala Pro Gly 
            660                 665                 670         


Gly Lys Gly Asp Ala Gly Ala Pro Gly Glu Arg Gly Pro Pro Gly Leu 
        675                 680                 685             


Ala Gly Ala Pro Gly Leu Arg Gly Gly Ala Gly Pro Pro Gly Pro Glu 
    690                 695                 700                 


Gly Gly Lys Gly Ala Ala Gly Pro Pro Gly Pro Pro Gly Ala Ala Gly 
705                 710                 715                 720 


Thr Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly Gly Leu Gly Ser 
                725                 730                 735     


Pro Gly Pro Lys Gly Asp Lys Gly Glu Pro Gly Gly Pro Gly Ala Asp 
            740                 745                 750         


Gly Val Pro Gly Lys Asp Gly Pro Arg Gly Pro Thr Gly Pro Ile Gly 
        755                 760                 765             


Pro Pro Gly Pro Ala Gly Gln Pro Gly Asp Lys Gly Glu Gly Gly Ala 
    770                 775                 780                 


Pro Gly Leu Pro Gly Ile Ala Gly Pro Arg Gly Ser Pro Gly Glu Arg 
785                 790                 795                 800 


Gly Glu Thr Gly Pro Pro Gly Pro Ala Gly Phe Pro Gly Ala Pro Gly 
                805                 810                 815     


Gln Asn Gly Glu Pro Gly Gly Lys Gly Glu Arg Gly Ala Pro Gly Glu 
            820                 825                 830         


Lys Gly Glu Gly Gly Pro Pro Gly Val Ala Gly Pro Pro Gly Gly Ser 
        835                 840                 845             


Gly Pro Ala Gly Pro Pro Gly Pro Gln Gly Val Lys Gly Glu Arg Gly 
    850                 855                 860                 


Ser Pro Gly Gly Pro Gly Ala Ala Gly Phe Pro Gly Ala Arg Gly Leu 
865                 870                 875                 880 


Pro Gly Pro Pro Gly Ser Asn Gly Asn Pro Gly Pro Pro Gly Pro Ser 
                885                 890                 895     


Gly Ser Pro Gly Lys Asp Gly Pro Pro Gly Pro Ala Gly Asn Thr Gly 
            900                 905                 910         


Ala Pro Gly Ser Pro Gly Val Ser Gly Pro Lys Gly Asp Ala Gly Gln 
        915                 920                 925             


Pro Gly Glu Lys Gly Ser Pro Gly Ala Gln Gly Pro Pro Gly Ala Pro 
    930                 935                 940                 


Gly Pro Leu Gly Ile Ala Gly Ile Thr Gly Ala Arg Gly Leu Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Met Pro Gly Pro Arg Gly Ser Pro Gly Pro Gln Gly Val 
                965                 970                 975     


Lys Gly Glu Ser Gly Lys Pro Gly Ala Asn Gly Leu Ser Gly Glu Arg 
            980                 985                 990         


Gly Pro Pro Gly Pro Gln Gly Leu  Pro Gly Leu Ala Gly  Thr Ala Gly 
        995                 1000                 1005             


Glu Pro  Gly Arg Asp Gly Asn  Pro Gly Ser Asp Gly  Leu Pro Gly 
    1010                 1015                 1020             


Arg Asp  Gly Ser Pro Gly Gly  Lys Gly Asp Arg Gly  Glu Asn Gly 
    1025                 1030                 1035             


Ser Pro  Gly Ala Pro Gly Ala  Pro Gly His Pro Gly  Pro Pro Gly 
    1040                 1045                 1050             


Pro Val  Gly Pro Ala Gly Lys  Ser Gly Asp Arg Gly  Glu Ser Gly 
    1055                 1060                 1065             


Pro Ala  Gly Pro Ala Gly Ala  Pro Gly Pro Ala Gly  Ser Arg Gly 
    1070                 1075                 1080             


Ala Pro  Gly Pro Gln Gly Pro  Arg Gly Asp Lys Gly  Glu Thr Gly 
    1085                 1090                 1095             


Glu Arg  Gly Ala Ala Gly Ile  Lys Gly His Arg Gly  Phe Pro Gly 
    1100                 1105                 1110             


Asn Pro  Gly Ala Pro Gly Ser  Pro Gly Pro Ala Gly  Gln Gln Gly 
    1115                 1120                 1125             


Ala Ile  Gly Ser Pro Gly Pro  Ala Gly Pro Arg Gly  Pro Val Gly 
    1130                 1135                 1140             


Pro Ser  Gly Pro Pro Gly Lys  Asp Gly Thr Ser Gly  His Pro Gly 
    1145                 1150                 1155             


Pro Ile  Gly Pro Pro Gly Pro  Arg Gly Asn Arg Gly  Glu Arg Gly 
    1160                 1165                 1170             


Ser Glu  Gly Ser Pro Gly His  Pro Gly Gln Pro Gly  Pro Pro Gly 
    1175                 1180                 1185             


Pro Pro  Gly Ala Pro Gly Pro  Cys Cys Gly Gly Val  Gly Ala Ala 
    1190                 1195                 1200             


Ala Ile  Ala Gly Ile Gly Gly  Glu Lys Ala Gly Gly  Phe Ala Pro 
    1205                 1210                 1215             


Tyr Tyr  Gly Asp Glu Pro Met  Asp Phe Lys Ile Asn  Thr Asp Glu 
    1220                 1225                 1230             


Ile Met  Thr Ser Leu Lys Ser  Val Asn Gly Gln Ile  Glu Ser Leu 
    1235                 1240                 1245             


Ile Ser  Pro Asp Gly Ser Arg  Lys Asn Pro Ala Arg  Asn Cys Arg 
    1250                 1255                 1260             


Asp Leu  Lys Phe Cys His Pro  Glu Leu Lys Ser Gly  Glu Tyr Trp 
    1265                 1270                 1275             


Val Asp  Pro Asn Gln Gly Cys  Lys Leu Asp Ala Ile  Lys Val Phe 
    1280                 1285                 1290             


Cys Asn  Met Glu Thr Gly Glu  Thr Cys Ile Ser Ala  Asn Pro Leu 
    1295                 1300                 1305             


Asn Val  Pro Arg Lys His Trp  Trp Thr Asp Ser Ser  Ala Glu Lys 
    1310                 1315                 1320             


Lys His  Val Trp Phe Gly Glu  Ser Met Asp Gly Gly  Phe Gln Phe 
    1325                 1330                 1335             


Ser Tyr  Gly Asn Pro Glu Leu  Pro Glu Asp Val Leu  Asp Val Gln 
    1340                 1345                 1350             


Leu Ala  Phe Leu Arg Leu Leu  Ser Ser Arg Ala Ser  Gln Asn Ile 
    1355                 1360                 1365             


Thr Tyr  His Cys Lys Asn Ser  Ile Ala Tyr Met Asp  Gln Ala Ser 
    1370                 1375                 1380             


Gly Asn  Val Lys Lys Ala Leu  Lys Leu Met Gly Ser  Asn Glu Gly 
    1385                 1390                 1395             


Glu Phe  Lys Ala Glu Gly Asn  Ser Lys Phe Thr Tyr  Thr Val Leu 
    1400                 1405                 1410             


Glu Asp  Gly Cys Thr Lys His  Thr Gly Glu Trp Ser  Lys Thr Val 
    1415                 1420                 1425             


Phe Glu  Tyr Arg Thr Arg Lys  Ala Val Arg Leu Pro  Ile Val Asp 
    1430                 1435                 1440             


Ile Ala  Pro Tyr Asp Ile Gly  Gly Pro Asp Gln Glu  Phe Gly Val 
    1445                 1450                 1455             


Asp Val  Gly Pro Val Cys Phe  Leu 
    1460                 1465     


<210>  104
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL3A1

<400>  104
gaggacggcc aggactt                                                      17


<210>  105
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL3A1

<400>  105
ggtccaactt cacccttag                                                    19


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL3A1 probe

<400>  106
agtgatggtc aaccaggccc t                                                 21


<210>  107
<211>  6930
<212>  DNA
<213>  Homo sapiens

<400>  107
gaccgttgct tggcagacac tggatggtta tgagcctgaa caagctgaaa aggggcagga       60

aaagaagtgg aggcagcatt cttcctattt aaagctgcat cgcttgaaaa aagttttcgc      120

agactgtgct ggagctggtg ctgaaaaagg gggtttgcag aggctgccct ggggctggtg      180

ctgaaagaag agcccacagc tgacttcatg gtgctacaat aacctcagaa tctacttttc      240

actctcagga gaacccacat gtctaatatt tagacatgat ggcaaactgg gcggaagcaa      300

gacctctcct cattcttatt gttttattag ggcaatttgt ctcaataaaa gcccaggaag      360

aagacgagga tgaaggatat ggtgaagaaa tagcctgcac tcagaatggc cagatgtact      420

taaacaggga catttggaaa cctgcccctt gtcagatctg tgtctgtgac aatggagcca      480

ttctctgtga caagatagaa tgccaggatg tgctggactg tgccgaccct gtaacgcccc      540

ctggggaatg ctgtcctgtc tgttcacaaa cacctggagg tggcaataca aattttggta      600

gaggaagaaa gggacaaaag ggagaaccag gattagtgcc tgttgtaaca ggcatacgtg      660

gtcgtccagg accggcagga cctccaggat cacagggacc aagaggagag cgagggccaa      720

aaggaagacc tggccctcgt ggacctcagg gaattgatgg agaaccaggt gttcctggtc      780

aacctggtgc tccaggacct cctggacatc cgtcccaccc aggacccgat ggcttgagca      840

ggccgttttc agctcaaatg gctgggttgg atgaaaaatc tggacttggg agtcaagtag      900

gactaatgcc tggctctgtg ggtcctgttg gcccaagggg accacagggt ttacaaggac      960

agcaaggtgg tgcaggacct acaggacctc ctggtgaacc tggtgatcct ggaccaatgg     1020

gtccgattgg ttcacgtgga ccagagggcc ctcctggtaa acctggggaa gatggtgaac     1080

ctggcagaaa tggaaatcct ggtgaagtgg gatttgcagg atctccggga gctcgtggat     1140

ttcctggggc tcctggtctt ccaggtctga agggtcaccg aggacacaaa ggtcttgaag     1200

gccctaaagg tgaagttgga gcacctggtt ccaagggtga agctggcccc actggtccaa     1260

tgggtgccat gggtcctctg ggtccgaggg gaatgccagg agagagaggg agacttgggc     1320

cacagggtgc tcctggacaa cgaggtgcac atggtatgcc tggaaaacct ggaccaatgg     1380

gtcctcttgg gataccaggc tcttctggtt ttccaggaaa tcctggaatg aagggagaag     1440

caggtcctac aggggcgcga ggccctgaag gtcctcaggg gcagagaggt gaaactgggc     1500

ccccaggtcc agttggctct ccaggtcttc ctggtgcaat aggaactgat ggtactcctg     1560

gtgccaaagg cccaacgggc tctccgggta cctctggtcc tcctggctca gcagggcctc     1620

ctggatctcc aggacctcag ggtagcactg gtcctcaggg aattcgaggc caaccgggtg     1680

atccaggagt tccaggtttc aaaggagaag ctggcccaaa aggggaacca gggccacatg     1740

gtattcaggg tccgataggc ccacccggtg aagaaggcaa aagaggtccc agaggtgacc     1800

caggaacagt tggtcctcca gggccagtgg gagaaagggg tgctcctggc aatcgtggtt     1860

ttccaggctc tgatggttta cctgggccaa agggtgctca aggagaacgg ggtcctgtag     1920

gttcttcagg acccaaagga agccaggggg atccaggacg tccaggggaa cctgggcttc     1980

caggtgctcg gggtttgaca ggaaatcctg gtgttcaagg tcctgaagga aaacttggac     2040

ctttgggtgc gccaggggaa gatggccgtc caggtcctcc aggctccata ggaatcagag     2100

ggcagcccgg gagcatgggc cttccaggcc ccaaaggtag cagtggtgac cctgggaaac     2160

ctggagaagc aggaaatgct ggagttcctg ggcagagggg agctcctgga aaagatggtg     2220

aagttggtcc ttctggtcct gtgggcccgc cgggtctagc tggtgaaaga ggagaacaag     2280

gacctccagg ccccacaggt tttcaggggc ttcctggtcc tccagggcct cctggagaag     2340

gtggaaaacc aggtgatcaa ggtgttcctg gagatcccgg agcagttggc ccgttaggac     2400

ctagaggaga acgaggaaat cctggggaaa gaggagaacc tgggataact ggactccctg     2460

gtgagaaggg aatggctgga ggacatggtc ctgatggccc aaaaggcagt ccaggtccat     2520

ctgggacccc tggagataca ggcccaccag gtcttcaagg tatgccggga gaaagaggaa     2580

ttgcaggaac tcctggcccc aagggtgaca gaggtggcat aggagaaaaa ggtgctgaag     2640

gcacagctgg aaatgatggt gcaagaggtc ttccaggtcc tttgggccct ccaggtccgg     2700

caggtcctac tggagaaaag ggtgaacctg gtcctcgagg tttagttggc cctcctggct     2760

cccggggcaa tcctggttct cgaggtgaaa atgggccaac tggagctgtt ggttttgccg     2820

gaccccaggg tcctgacgga cagcctggag taaaaggtga acctggagag ccaggacaga     2880

agggagatgc tggttctcct ggaccacaag gtttagcagg atcccctggc cctcatggtc     2940

ctaatggtgt tcctggacta aaaggtggtc gaggaaccca aggtccgcct ggtgctacag     3000

gatttcctgg ttctgcgggc agagttggac ctccaggccc tgctggagct ccaggacctg     3060

cgggacccct aggggaaccc gggaaggagg gacctccagg tcttcgtggg gaccctggct     3120

ctcatgggcg tgtgggagat cgaggaccag ctggcccccc tggtggccca ggagacaaag     3180

gggacccagg agaagatggg caacctggtc cagatggccc ccctggtcca gctggaacga     3240

ccgggcagag aggaattgtt ggcatgcctg ggcaacgtgg agagagaggc atgcccggcc     3300

taccaggccc agcgggaaca ccaggaaaag taggaccaac tggtgcaaca ggagataaag     3360

gtccacctgg acctgtgggg cccccaggct ccaatggtcc tgtaggggaa cctggaccag     3420

aaggtccagc tggcaatgat ggtaccccag gacgggatgg tgctgttgga gaacgtggtg     3480

atcgtggaga ccctgggcct gcaggtctgc caggctctca gggtgcccct ggaactcctg     3540

gccctgtggg tgctccagga gatgcaggac aaagaggaga tccgggttct cggggtccta     3600

taggaccacc tggtcgagct gggaaacgtg gattacctgg accccaagga cctcgtggtg     3660

acaaaggtga tcatggagac cgaggcgaca gaggtcagaa gggccacaga ggctttactg     3720

gtcttcaggg tcttcctggc cctcctggtc caaatggtga acaaggaagt gctggaatcc     3780

ctggaccatt tggcccaaga ggtcctccag gcccagttgg tccttcaggt aaagaaggaa     3840

accctgggcc acttgggcca attggacctc caggtgtacg aggcagtgta ggagaagcag     3900

gacctgaggg ccctcctggt gagcctggcc cacctggccc tccgggtccc cctggccacc     3960

ttacagctgc tcttggggat atcatggggc actatgatga aagcatgcca gatccacttc     4020

ctgagtttac tgaagatcag gcggctcctg atgacaaaaa caaaacggac ccaggggttc     4080

atgctaccct gaagtcactc agtagtcaga ttgaaaccat gcgcagcccc gatggctcga     4140

aaaagcaccc agcccgcacg tgtgatgacc taaagctttg ccattccgca aagcagagtg     4200

gtgaatactg gattgatcct aaccaaggat ctgttgaaga tgcaatcaaa gtttactgca     4260

acatggaaac aggagaaaca tgtatttcag caaacccatc cagtgtacca cgtaaaacct     4320

ggtgggccag taaatctcct gacaataaac ctgtttggta tggtcttgat atgaacagag     4380

ggtctcagtt cgcttatgga gaccaccaat cacctaatac agccattact cagatgactt     4440

ttttgcgcct tttatcaaaa gaagcctccc agaacatcac ttacatctgt aaaaacagtg     4500

taggatacat ggacgatcaa gctaagaacc tcaaaaaagc tgtggttctc aaaggggcaa     4560

atgacttaga tatcaaagca gagggaaata ttagattccg gtatatcgtt cttcaagaca     4620

cttgctctaa gcggaatgga aatgtgggca agactgtctt tgaatataga acacagaatg     4680

tggcacgctt gcccatcata gatcttgctc ctgtggatgt tggcggcaca gaccaggaat     4740

tcggcgttga aattgggcca gtttgttttg tgtaaagtaa gccaagacac atcgacaatg     4800

agcaccacca tcaatgacca ccgccattca caagaacttt gactgtttga agttgatcct     4860

gagactcttg aagtaatggc tgatcctgca tcagcattgt atatatggtc ttaagtgcct     4920

ggcctcctta tccttcagaa tatttatttt acttacaatc ctcaagtttt aattgatttt     4980

aaatattttt caatacaaca gtttaggttt aagatgacca atgacaatga ccacctttgc     5040

agaaagtaaa ctgattgaat aaataaatct ccgttttctt caatttattt cagtgtaatg     5100

aaaaagttgc ttagtattta tgaggaaatt cttcttcctg gcaggtagct taaagagtgg     5160

ggtatataga gccacaacac atgtttattt tgcttggctg cagttgaaaa atagaaatta     5220

gtgccctttt gtgacctctc attccaagat tgtcaattaa aaatgagttt aaaatgttta     5280

acttgtgatc gagacctaca tgcatgtctt gatattgtgt aactataata gagactcttt     5340

aaggagaatc ttaaaaaaaa aaaaacgttt ctcactgtct taaatagaat ttttaaatag     5400

tatatattca gtggcatttt ggagaacaaa gtgaatttac ttcgacttct taaatttttg     5460

taaaagacta taagtttaga catctttctc attcaaattt aaagatatct ttctcctctt     5520

gatcaatcta tcaatattga tagaagtcac actagtatat accatttaat acatttacac     5580

tttcttattt aagaagatat tgaatgcaaa ataattgaca tatagaactt tacaaacata     5640

tgtccaagga ctctaaattg agactcttcc acatgtacaa tctcatcatc ctgaagccta     5700

taatgaagaa aaagatctag aaactgagtt gtggagctga ctctaatcaa atgtgatgat     5760

tggaattaga ccatttggcc tttgaacttt cataggaaaa atgacccaac atttcttagc     5820

atgagctacc tcatctctag aagctgggat ggacttacta ttcttgttta tattttagat     5880

actgaaaggt gctatgcttc tgttattatt ccaagactgg agataggcag ggctaaaaag     5940

gtattattat ttttccttta atgatggtgc taaaattctt cctataaaat tccttaaaaa     6000

taaagatggt ttaatcacta ccattgtgaa aacataactg ttagacttcc cgtttctgaa     6060

agaaagagca tcgttccaat gcttgttcac tgttcctctg tcatactgta tctggaatgc     6120

tttgtaatac ttgcatgctt cttagaccag aacatgtagg tccccttgtg tctcaatact     6180

ttttttttct taattgcatt tgttggctct attttaattt ttttctttta aaataaacag     6240

ctgggaccat cccaaaagac aagccatgca tacaactttg gtcatgtatc tctgcaaagc     6300

atcaaattaa atgcacgctt ttgtcatgtc agtggttttt gttttgtgaa attcctttga     6360

ccatattaga tctatttcat ttccaatagt gaaaaggaga tgtggtggta tactttgttt     6420

gccatttgtt taaaagatac aacggatacc ttctatcatg tatgtactgg cttataaatg     6480

aaaatctatc tacaacatta cccacaaagg caacatgaca ccaattatca ctgcctctgc     6540

ccttaaaaat gtcagagtag tattattgat aaaaagggca agcaatagat ttttcatgac     6600

tgaataaact gtaataataa aacatatgtc tcaaagtgta tcacatatga atttagccta     6660

attgttttca gtttcattct caatatttag tttacaacat cattttcccc taaactggtt     6720

atattttgac ctgtatatct taaatttgag tatttatatg cctaaataca tgtgtgagtt     6780

ttgtttgact tccaagtcca aactataaga ttatataagt tcatatagat gaatcagaaa     6840

tatgtggtaa tactattaag tcacaaacac taacaatttc caactataga aataacagtt     6900

cttatttgga ttttgggaat gctaccaata                                      6930


<210>  108
<211>  1499
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Met Ala Asn Trp Ala Glu Ala Arg Pro Leu Leu Ile Leu Ile Val 
1               5                   10                  15      


Leu Leu Gly Gln Phe Val Ser Ile Lys Ala Gln Glu Glu Asp Glu Asp 
            20                  25                  30          


Glu Gly Tyr Gly Glu Glu Ile Ala Cys Thr Gln Asn Gly Gln Met Tyr 
        35                  40                  45              


Leu Asn Arg Asp Ile Trp Lys Pro Ala Pro Cys Gln Ile Cys Val Cys 
    50                  55                  60                  


Asp Asn Gly Ala Ile Leu Cys Asp Lys Ile Glu Cys Gln Asp Val Leu 
65                  70                  75                  80  


Asp Cys Ala Asp Pro Val Thr Pro Pro Gly Glu Cys Cys Pro Val Cys 
                85                  90                  95      


Ser Gln Thr Pro Gly Gly Gly Asn Thr Asn Phe Gly Arg Gly Arg Lys 
            100                 105                 110         


Gly Gln Lys Gly Glu Pro Gly Leu Val Pro Val Val Thr Gly Ile Arg 
        115                 120                 125             


Gly Arg Pro Gly Pro Ala Gly Pro Pro Gly Ser Gln Gly Pro Arg Gly 
    130                 135                 140                 


Glu Arg Gly Pro Lys Gly Arg Pro Gly Pro Arg Gly Pro Gln Gly Ile 
145                 150                 155                 160 


Asp Gly Glu Pro Gly Val Pro Gly Gln Pro Gly Ala Pro Gly Pro Pro 
                165                 170                 175     


Gly His Pro Ser His Pro Gly Pro Asp Gly Leu Ser Arg Pro Phe Ser 
            180                 185                 190         


Ala Gln Met Ala Gly Leu Asp Glu Lys Ser Gly Leu Gly Ser Gln Val 
        195                 200                 205             


Gly Leu Met Pro Gly Ser Val Gly Pro Val Gly Pro Arg Gly Pro Gln 
    210                 215                 220                 


Gly Leu Gln Gly Gln Gln Gly Gly Ala Gly Pro Thr Gly Pro Pro Gly 
225                 230                 235                 240 


Glu Pro Gly Asp Pro Gly Pro Met Gly Pro Ile Gly Ser Arg Gly Pro 
                245                 250                 255     


Glu Gly Pro Pro Gly Lys Pro Gly Glu Asp Gly Glu Pro Gly Arg Asn 
            260                 265                 270         


Gly Asn Pro Gly Glu Val Gly Phe Ala Gly Ser Pro Gly Ala Arg Gly 
        275                 280                 285             


Phe Pro Gly Ala Pro Gly Leu Pro Gly Leu Lys Gly His Arg Gly His 
    290                 295                 300                 


Lys Gly Leu Glu Gly Pro Lys Gly Glu Val Gly Ala Pro Gly Ser Lys 
305                 310                 315                 320 


Gly Glu Ala Gly Pro Thr Gly Pro Met Gly Ala Met Gly Pro Leu Gly 
                325                 330                 335     


Pro Arg Gly Met Pro Gly Glu Arg Gly Arg Leu Gly Pro Gln Gly Ala 
            340                 345                 350         


Pro Gly Gln Arg Gly Ala His Gly Met Pro Gly Lys Pro Gly Pro Met 
        355                 360                 365             


Gly Pro Leu Gly Ile Pro Gly Ser Ser Gly Phe Pro Gly Asn Pro Gly 
    370                 375                 380                 


Met Lys Gly Glu Ala Gly Pro Thr Gly Ala Arg Gly Pro Glu Gly Pro 
385                 390                 395                 400 


Gln Gly Gln Arg Gly Glu Thr Gly Pro Pro Gly Pro Val Gly Ser Pro 
                405                 410                 415     


Gly Leu Pro Gly Ala Ile Gly Thr Asp Gly Thr Pro Gly Ala Lys Gly 
            420                 425                 430         


Pro Thr Gly Ser Pro Gly Thr Ser Gly Pro Pro Gly Ser Ala Gly Pro 
        435                 440                 445             


Pro Gly Ser Pro Gly Pro Gln Gly Ser Thr Gly Pro Gln Gly Ile Arg 
    450                 455                 460                 


Gly Gln Pro Gly Asp Pro Gly Val Pro Gly Phe Lys Gly Glu Ala Gly 
465                 470                 475                 480 


Pro Lys Gly Glu Pro Gly Pro His Gly Ile Gln Gly Pro Ile Gly Pro 
                485                 490                 495     


Pro Gly Glu Glu Gly Lys Arg Gly Pro Arg Gly Asp Pro Gly Thr Val 
            500                 505                 510         


Gly Pro Pro Gly Pro Val Gly Glu Arg Gly Ala Pro Gly Asn Arg Gly 
        515                 520                 525             


Phe Pro Gly Ser Asp Gly Leu Pro Gly Pro Lys Gly Ala Gln Gly Glu 
    530                 535                 540                 


Arg Gly Pro Val Gly Ser Ser Gly Pro Lys Gly Ser Gln Gly Asp Pro 
545                 550                 555                 560 


Gly Arg Pro Gly Glu Pro Gly Leu Pro Gly Ala Arg Gly Leu Thr Gly 
                565                 570                 575     


Asn Pro Gly Val Gln Gly Pro Glu Gly Lys Leu Gly Pro Leu Gly Ala 
            580                 585                 590         


Pro Gly Glu Asp Gly Arg Pro Gly Pro Pro Gly Ser Ile Gly Ile Arg 
        595                 600                 605             


Gly Gln Pro Gly Ser Met Gly Leu Pro Gly Pro Lys Gly Ser Ser Gly 
    610                 615                 620                 


Asp Pro Gly Lys Pro Gly Glu Ala Gly Asn Ala Gly Val Pro Gly Gln 
625                 630                 635                 640 


Arg Gly Ala Pro Gly Lys Asp Gly Glu Val Gly Pro Ser Gly Pro Val 
                645                 650                 655     


Gly Pro Pro Gly Leu Ala Gly Glu Arg Gly Glu Gln Gly Pro Pro Gly 
            660                 665                 670         


Pro Thr Gly Phe Gln Gly Leu Pro Gly Pro Pro Gly Pro Pro Gly Glu 
        675                 680                 685             


Gly Gly Lys Pro Gly Asp Gln Gly Val Pro Gly Asp Pro Gly Ala Val 
    690                 695                 700                 


Gly Pro Leu Gly Pro Arg Gly Glu Arg Gly Asn Pro Gly Glu Arg Gly 
705                 710                 715                 720 


Glu Pro Gly Ile Thr Gly Leu Pro Gly Glu Lys Gly Met Ala Gly Gly 
                725                 730                 735     


His Gly Pro Asp Gly Pro Lys Gly Ser Pro Gly Pro Ser Gly Thr Pro 
            740                 745                 750         


Gly Asp Thr Gly Pro Pro Gly Leu Gln Gly Met Pro Gly Glu Arg Gly 
        755                 760                 765             


Ile Ala Gly Thr Pro Gly Pro Lys Gly Asp Arg Gly Gly Ile Gly Glu 
    770                 775                 780                 


Lys Gly Ala Glu Gly Thr Ala Gly Asn Asp Gly Ala Arg Gly Leu Pro 
785                 790                 795                 800 


Gly Pro Leu Gly Pro Pro Gly Pro Ala Gly Pro Thr Gly Glu Lys Gly 
                805                 810                 815     


Glu Pro Gly Pro Arg Gly Leu Val Gly Pro Pro Gly Ser Arg Gly Asn 
            820                 825                 830         


Pro Gly Ser Arg Gly Glu Asn Gly Pro Thr Gly Ala Val Gly Phe Ala 
        835                 840                 845             


Gly Pro Gln Gly Pro Asp Gly Gln Pro Gly Val Lys Gly Glu Pro Gly 
    850                 855                 860                 


Glu Pro Gly Gln Lys Gly Asp Ala Gly Ser Pro Gly Pro Gln Gly Leu 
865                 870                 875                 880 


Ala Gly Ser Pro Gly Pro His Gly Pro Asn Gly Val Pro Gly Leu Lys 
                885                 890                 895     


Gly Gly Arg Gly Thr Gln Gly Pro Pro Gly Ala Thr Gly Phe Pro Gly 
            900                 905                 910         


Ser Ala Gly Arg Val Gly Pro Pro Gly Pro Ala Gly Ala Pro Gly Pro 
        915                 920                 925             


Ala Gly Pro Leu Gly Glu Pro Gly Lys Glu Gly Pro Pro Gly Leu Arg 
    930                 935                 940                 


Gly Asp Pro Gly Ser His Gly Arg Val Gly Asp Arg Gly Pro Ala Gly 
945                 950                 955                 960 


Pro Pro Gly Gly Pro Gly Asp Lys Gly Asp Pro Gly Glu Asp Gly Gln 
                965                 970                 975     


Pro Gly Pro Asp Gly Pro Pro Gly Pro Ala Gly Thr Thr Gly Gln Arg 
            980                 985                 990         


Gly Ile Val Gly Met Pro Gly Gln  Arg Gly Glu Arg Gly  Met Pro Gly 
        995                 1000                 1005             


Leu Pro  Gly Pro Ala Gly Thr  Pro Gly Lys Val Gly  Pro Thr Gly 
    1010                 1015                 1020             


Ala Thr  Gly Asp Lys Gly Pro  Pro Gly Pro Val Gly  Pro Pro Gly 
    1025                 1030                 1035             


Ser Asn  Gly Pro Val Gly Glu  Pro Gly Pro Glu Gly  Pro Ala Gly 
    1040                 1045                 1050             


Asn Asp  Gly Thr Pro Gly Arg  Asp Gly Ala Val Gly  Glu Arg Gly 
    1055                 1060                 1065             


Asp Arg  Gly Asp Pro Gly Pro  Ala Gly Leu Pro Gly  Ser Gln Gly 
    1070                 1075                 1080             


Ala Pro  Gly Thr Pro Gly Pro  Val Gly Ala Pro Gly  Asp Ala Gly 
    1085                 1090                 1095             


Gln Arg  Gly Asp Pro Gly Ser  Arg Gly Pro Ile Gly  Pro Pro Gly 
    1100                 1105                 1110             


Arg Ala  Gly Lys Arg Gly Leu  Pro Gly Pro Gln Gly  Pro Arg Gly 
    1115                 1120                 1125             


Asp Lys  Gly Asp His Gly Asp  Arg Gly Asp Arg Gly  Gln Lys Gly 
    1130                 1135                 1140             


His Arg  Gly Phe Thr Gly Leu  Gln Gly Leu Pro Gly  Pro Pro Gly 
    1145                 1150                 1155             


Pro Asn  Gly Glu Gln Gly Ser  Ala Gly Ile Pro Gly  Pro Phe Gly 
    1160                 1165                 1170             


Pro Arg  Gly Pro Pro Gly Pro  Val Gly Pro Ser Gly  Lys Glu Gly 
    1175                 1180                 1185             


Asn Pro  Gly Pro Leu Gly Pro  Ile Gly Pro Pro Gly  Val Arg Gly 
    1190                 1195                 1200             


Ser Val  Gly Glu Ala Gly Pro  Glu Gly Pro Pro Gly  Glu Pro Gly 
    1205                 1210                 1215             


Pro Pro  Gly Pro Pro Gly Pro  Pro Gly His Leu Thr  Ala Ala Leu 
    1220                 1225                 1230             


Gly Asp  Ile Met Gly His Tyr  Asp Glu Ser Met Pro  Asp Pro Leu 
    1235                 1240                 1245             


Pro Glu  Phe Thr Glu Asp Gln  Ala Ala Pro Asp Asp  Lys Asn Lys 
    1250                 1255                 1260             


Thr Asp  Pro Gly Val His Ala  Thr Leu Lys Ser Leu  Ser Ser Gln 
    1265                 1270                 1275             


Ile Glu  Thr Met Arg Ser Pro  Asp Gly Ser Lys Lys  His Pro Ala 
    1280                 1285                 1290             


Arg Thr  Cys Asp Asp Leu Lys  Leu Cys His Ser Ala  Lys Gln Ser 
    1295                 1300                 1305             


Gly Glu  Tyr Trp Ile Asp Pro  Asn Gln Gly Ser Val  Glu Asp Ala 
    1310                 1315                 1320             


Ile Lys  Val Tyr Cys Asn Met  Glu Thr Gly Glu Thr  Cys Ile Ser 
    1325                 1330                 1335             


Ala Asn  Pro Ser Ser Val Pro  Arg Lys Thr Trp Trp  Ala Ser Lys 
    1340                 1345                 1350             


Ser Pro  Asp Asn Lys Pro Val  Trp Tyr Gly Leu Asp  Met Asn Arg 
    1355                 1360                 1365             


Gly Ser  Gln Phe Ala Tyr Gly  Asp His Gln Ser Pro  Asn Thr Ala 
    1370                 1375                 1380             


Ile Thr  Gln Met Thr Phe Leu  Arg Leu Leu Ser Lys  Glu Ala Ser 
    1385                 1390                 1395             


Gln Asn  Ile Thr Tyr Ile Cys  Lys Asn Ser Val Gly  Tyr Met Asp 
    1400                 1405                 1410             


Asp Gln  Ala Lys Asn Leu Lys  Lys Ala Val Val Leu  Lys Gly Ala 
    1415                 1420                 1425             


Asn Asp  Leu Asp Ile Lys Ala  Glu Gly Asn Ile Arg  Phe Arg Tyr 
    1430                 1435                 1440             


Ile Val  Leu Gln Asp Thr Cys  Ser Lys Arg Asn Gly  Asn Val Gly 
    1445                 1450                 1455             


Lys Thr  Val Phe Glu Tyr Arg  Thr Gln Asn Val Ala  Arg Leu Pro 
    1460                 1465                 1470             


Ile Ile  Asp Leu Ala Pro Val  Asp Val Gly Gly Thr  Asp Gln Glu 
    1475                 1480                 1485             


Phe Gly  Val Glu Ile Gly Pro  Val Cys Phe Val 
    1490                 1495                 


<210>  109
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL5A2

<400>  109
aagaggagaa caaggacctc                                                   20


<210>  110
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL5A2_reverse primer

<400>  110
atctccagga acaccttgat                                                   20


<210>  111
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COL5A2_probe

<400>  111
tttccacctt ctccaggagg cc                                                22


<210>  112
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  112
agtacagtat aaaacttcac agtgccaata ccatgaagag gagctcagac agctcttacc       60

acatgataca agagccggct ggtggaagag tggggaccag aaagagaatt tgctgaagag      120

gagaaggaaa aaaaaaacac caaaaaaaaa aataaaaaaa tccacacaca caaaaaaacc      180

tgcgcgtgag gggggaggaa aagcagggcc ttttaaaaag gcaatcacaa caacttttgc      240

tgccaggatg cccttgcttt ggctgagagg atttctgttg gcaagttgct ggattatagt      300

gaggagttcc cccaccccag gatccgaggg gcacagcgcg gcccccgact gtccgtcctg      360

tgcgctggcc gccctcccaa aggatgtacc caactctcag ccagagatgg tggaggccgt      420

caagaagcac attttaaaca tgctgcactt gaagaagaga cccgatgtca cccagccggt      480

acccaaggcg gcgcttctga acgcgatcag aaagcttcat gtgggcaaag tcggggagaa      540

cgggtatgtg gagatagagg atgacattgg aaggagggca gaaatgaatg aacttatgga      600

gcagacctcg gagatcatca cgtttgccga gtcaggaaca gccaggaaga cgctgcactt      660

cgagatttcc aaggaaggca gtgacctgtc agtggtggag cgtgcagaag tctggctctt      720

cctaaaagtc cccaaggcca acaggaccag gaccaaagtc accatccgcc tcttccagca      780

gcagaagcac ccgcagggca gcttggacac aggggaagag gccgaggaag tgggcttaaa      840

gggggagagg agtgaactgt tgctctctga aaaagtagta gacgctcgga agagcacctg      900

gcatgtcttc cctgtctcca gcagcatcca gcggttgctg gaccagggca agagctccct      960

ggacgttcgg attgcctgtg agcagtgcca ggagagtggc gccagcttgg ttctcctggg     1020

caagaagaag aagaaagaag aggaggggga agggaaaaag aagggcggag gtgaaggtgg     1080

ggcaggagca gatgaggaaa aggagcagtc gcacagacct ttcctcatgc tgcaggcccg     1140

gcagtctgaa gaccaccctc atcgccggcg tcggcggggc ttggagtgtg atggcaaggt     1200

caacatctgc tgtaagaaac agttctttgt cagtttcaag gacatcggct ggaatgactg     1260

gatcattgct ccctctggct atcatgccaa ctactgcgag ggtgagtgcc cgagccatat     1320

agcaggcacg tccgggtcct cactgtcctt ccactcaaca gtcatcaacc actaccgcat     1380

gcggggccat agcccctttg ccaacctcaa atcgtgctgt gtgcccacca agctgagacc     1440

catgtccatg ttgtactatg atgatggtca aaacatcatc aaaaaggaca ttcagaacat     1500

gatcgtggag gagtgtgggt gctcatagag ttgcccagcc cagggggaaa gggagcaaga     1560

gttgtccaga gaagacagtg gcaaaatgaa gaaattttta aggtttctga gttaaccaga     1620

aaaatagaaa ttaaaaacaa aacaaaaaaa aaaacaaaaa aaaacaaaag taaattaaaa     1680

acaaaacctg atgaaacaga tgaaggaaga tgtggaaaaa atccttagcc agggctcaga     1740

gatgaagcag tgaaagagac aggaattggg agggaaaggg agaatggtgt accctttatt     1800

tcttctgaaa tcacactgat gacatcagtt gtttaaacgg ggtattgtcc tttcccccct     1860

tgaggttccc ttgtgagcct tgaatcaacc aatctagtct gcagtagtgt ggactagaac     1920

aacccaaata gcatctagaa agccatgagt ttgaaagggc ccatcacagg cactttccta     1980

cccaattacc caggtcataa ggtatgtctg tgtgacactt atctctgtgt atatcagcat     2040

acacacacac acacacacac acacacacac acacaggcat ttccacacat tacatatata     2100

cacatactgg taaaagaaca atcgtgtgca ggtggtcaca cttccttttt ctgtaccact     2160

tttgcaacaa aacaa                                                      2175


<210>  113
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INHBA_forward primer

<400>  114
cctcggagat catcacgttt                                                   20


<210>  115
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INHBA_reverse primer

<400>  115
cactgccttc cttggaaatc t                                                 21


<210>  116
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  INHBA probe

<400>  116
cagccaggaa gacgctgcac tt                                                22


<210>  117
<211>  5898
<212>  DNA
<213>  Homo sapiens

<400>  117
aaaagtgagt ccctgccttc cctctctccg tctggctcct cccaggcctg tctggcaggg       60

gccggggtgc aggaggagga gacggcatcc agtacagagg ggctggactt ggacccctgc      120

agcagccctg cacaggagaa gcggcatata aagccgcgct gcccgggagc cgctcggcca      180

cgtccaccgg agcatcctgc actgcagggc cggtctctcg ctccagcaga gcctgcgcct      240

ttctgactcg gtccggaaca ctgaaaccag tcatcactgc atctttttgg caaaccagga      300

gctcagctgc aggaggcagg atggtctgga ggctggtcct gctggctctg tgggtgtggc      360

ccagcacgca agctggtcac caggacaaag acacgacctt cgaccttttc agtatcagca      420

acatcaaccg caagaccatt ggcgccaagc agttccgcgg gcccgacccc ggcgtgccgg      480

cttaccgctt cgtgcgcttt gactacatcc caccggtgaa cgcagatgac ctcagcaaga      540

tcaccaagat catgcggcag aaggagggct tcttcctcac ggcccagctc aagcaggacg      600

gcaagtccag gggcacgctg ttggctctgg agggccccgg tctctcccag aggcagttcg      660

agatcgtctc caacggcccc gcggacacgc tggatctcac ctactggatt gacggcaccc      720

ggcatgtggt ctccctggag gacgtcggcc tggctgactc gcagtggaag aacgtcaccg      780

tgcaggtggc tggcgagacc tacagcttgc acgtgggctg cgacctcata gacagcttcg      840

ctctggacga gcccttctac gagcacctgc aggcggaaaa gagccggatg tacgtggcca      900

aaggctctgc cagagagagt cacttcaggg gtttgcttca gaacgtccac ctagtgtttg      960

aaaactctgt ggaagatatt ctaagcaaga agggttgcca gcaaggccag ggagctgaga     1020

tcaacgccat cagtgagaac acagagacgc tgcgcctggg tccgcatgtc accaccgagt     1080

acgtgggccc cagctcggag aggaggcccg aggtgtgcga acgctcgtgc gaggagctgg     1140

gaaacatggt ccaggagctc tcggggctcc acgtcctcgt gaaccagctc agcgagaacc     1200

tcaagagagt gtcgaatgat aaccagtttc tctgggagct cattggtggc cctcctaaga     1260

caaggaacat gtcagcttgc tggcaggatg gccggttctt tgcggaaaat gaaacgtggg     1320

tggtggacag ctgcaccacg tgtacctgca agaaatttaa aaccatttgc caccaaatca     1380

cctgcccgcc tgcaacctgc gccagtccat cctttgtgga aggcgaatgc tgcccttcct     1440

gcctccactc ggtggacggt gaggagggct ggtctccgtg ggcagagtgg acccagtgct     1500

ccgtgacgtg tggctctggg acccagcaga gaggccggtc ctgtgacgtc accagcaaca     1560

cctgcttggg gccctccatc cagacacggg cttgcagtct gagcaagtgt gacacccgca     1620

tccggcagga cggcggctgg agccactggt caccttggtc ttcatgctct gtgacctgtg     1680

gagttggcaa tatcacacgc atccgtctct gcaactcccc agtgccccag atggggggca     1740

agaattgcaa agggagtggc cgggagacca aagcctgcca gggcgcccca tgcccaatcg     1800

atggccgctg gagcccctgg tccccgtggt cggcctgcac tgtcacctgt gccggtggga     1860

tccgggagcg cacccgggtc tgcaacagcc ctgagcctca gtacggaggg aaggcctgcg     1920

tgggggatgt gcaggagcgt cagatgtgca acaagaggag ctgccccgtg gatggctgtt     1980

tatccaaccc ctgcttcccg ggagcccagt gcagcagctt ccccgatggg tcctggtcat     2040

gcggctcctg ccctgtgggc ttcttgggca atggcaccca ctgtgaggac ctggacgagt     2100

gtgccctggt ccccgacatc tgcttctcca ccagcaaggt gcctcgctgt gtcaacactc     2160

agcctggctt ccactgcctg ccctgcccgc cccgatacag agggaaccag cccgtcgggg     2220

tcggcctgga agcagccaag acggaaaagc aagtgtgtga gcccgaaaac ccatgcaagg     2280

acaagacaca caactgccac aagcacgcgg agtgcatcta cctgggccac ttcagcgacc     2340

ccatgtacaa gtgcgagtgc cagacaggct acgcgggcga cgggctcatc tgcggggagg     2400

actcggacct ggacggctgg cccaacctca atctggtctg cgccaccaac gccacctacc     2460

actgcatcaa ggataactgc ccccatctgc caaattctgg gcaggaagac tttgacaagg     2520

acgggattgg cgatgcctgt gatgatgacg atgacaatga cggtgtgacc gatgagaagg     2580

acaactgcca gctcctcttc aatccccgcc aggctgacta tgacaaggat gaggttgggg     2640

accgctgtga caactgccct tacgtgcaca accctgccca gatcgacaca gacaacaatg     2700

gagagggtga cgcctgctcc gtggacattg atggggacga tgtcttcaat gaacgagaca     2760

attgtcccta cgtctacaac actgaccaga gggacacgga tggtgacggt gtgggggatc     2820

actgtgacaa ctgccccctg gtgcacaacc ctgaccagac cgacgtggac aatgaccttg     2880

ttggggacca gtgtgacaac aacgaggaca tagatgacga cggccaccag aacaaccagg     2940

acaactgccc ctacatctcc aacgccaacc aggctgacca tgacagagac ggccagggcg     3000

acgcctgtga ccctgatgat gacaacgatg gcgtccccga tgacagggac aactgccggc     3060

ttgtgttcaa cccagaccag gaggacttgg acggtgatgg acggggtgat atttgtaaag     3120

atgattttga caatgacaac atcccagata ttgatgatgt gtgtcctgaa aacaatgcca     3180

tcagtgagac agacttcagg aacttccaga tggtcccctt ggatcccaaa gggaccaccc     3240

aaattgatcc caactgggtc attcgccatc aaggcaagga gctggttcag acagccaact     3300

cggaccccgg catcgctgta ggttttgacg agtttgggtc tgtggacttc agtggcacat     3360

tctacgtaaa cactgaccgg gacgacgact atgccggctt cgtctttggt taccagtcaa     3420

gcagccgctt ctatgtggtg atgtggaagc aggtgacgca gacctactgg gaggaccagc     3480

ccacgcgggc ctatggctac tccggcgtgt ccctcaaggt ggtgaactcc accacgggga     3540

cgggcgagca cctgaggaac gcgctgtggc acacggggaa cacgccgggg caggtgcgaa     3600

ccttatggca cgaccccagg aacattggct ggaaggacta cacggcctat aggtggcacc     3660

tgactcacag gcccaagact ggctacatca gagtcttagt gcatgaagga aaacaggtca     3720

tggcagactc aggacctatc tatgaccaaa cctacgctgg cgggcggctg ggtctatttg     3780

tcttctctca agaaatggtc tatttctcag acctcaagta cgaatgcaga gatatttaaa     3840

caagatttgc tgcatttccg gcaatgccct gtgcatgcca tggtccctag acacctcagt     3900

tcattgtggt ccttgtggct tctctctcta gcagcacctc ctgtcccttg accttaactc     3960

tgatggttct tcacctcctg ccagcaaccc caaacccaag tgccttcaga ggataaatat     4020

caatggaact cagagatgaa catctaaccc actagaggaa accagtttgg tgatatatga     4080

gactttatgt ggagtgaaaa ttgggcatgc cattacattg ctttttcttg tttgtttaaa     4140

aagaatgacg tttacatata aaatgtaatt acttattgta tttatgtgta tatggagttg     4200

aagggaatac tgtgcataag ccattatgat aaattaagca tgaaaaatat tgctgaacta     4260

cttttggtgc ttaaagttgt cactattctt gaattagagt tgctctacaa tgacacacaa     4320

atcccattaa ataaattata aacaagggtc aattcaaatt tgaagtaatg ttttagtaag     4380

gagagattag aagacaacag gcatagcaaa tgacataagc taccgattaa ctaatcggaa     4440

catgtaaaac agttacaaaa ataaacgaac tctcctcttg tcctacaatg aaagccctca     4500

tgtgcagtag agatgcagtt tcatcaaaga acaaacatcc ttgcaaatgg gtgtgacgcg     4560

gttccagatg tggatttggc aaaacctcat ttaagtaaaa ggttagcaga gcaaagtgcg     4620

gtgctttagc tgctgcttgt gccgctgtgg cgtcggggag gctcctgcct gagcttcctt     4680

ccccagcttt gctgcctgag aggaaccaga gcagacgcac aggccggaaa aggcgcatct     4740

aacgcgtatc taggctttgg taactgcgga caagttgctt ttacctgatt tgatgataca     4800

tttcattaag gttccagtta taaatatttt gttaatattt attaagtgac tatagaatgc     4860

aactccattt accagtaact tattttaaat atgcctagta acacatatgt agtataattt     4920

ctagaaacaa acatctaata agtatataat cctgtgaaaa tatgaggctt gataatatta     4980

ggttgtcacg atgaagcatg ctagaagctg taacagaata catagagaat aatgaggagt     5040

ttatgatgga accttaaata tataatgttg ccagcgattt tagttcaata tttgttactg     5100

ttatctatct gctgtatatg gaattctttt aattcaaacg ctgaaaagaa tcagcattta     5160

gtcttgccag gcacacccaa taatcagtca tgtgtaatat gcacaagttt gtttttgttt     5220

ttgttttttt tgttggttgg tttgtttttt tgctttaagt tgcatgatct ttctgcagga     5280

aatagtcact catcccactc cacataaggg gtttagtaag agaagtctgt ctgtctgatg     5340

atggataggg ggcaaatctt tttccccttt ctgttaatag tcatcacatt tctatgccaa     5400

acaggaacaa tccataactt tagtcttaat gtacacattg cattttgata aaattaattt     5460

tgttgtttcc tttgaggttg atcgttgtgt tgttgttttg ctgcactttt tacttttttg     5520

cgtgtggagc tgtattcccg agaccaacga agcgttggga tacttcatta aatgtagcga     5580

ctgtcaacag cgtgcaggtt ttctgtttct gtgttgtggg gtcaaccgta caatggtgtg     5640

ggagtgacga tgatgtgaat atttagaatg taccatattt tttgtaaatt atttatgttt     5700

ttctaaacaa atttatcgta taggttgatg aaacgtcatg tgttttgcca aagactgtaa     5760

atatttattt atgtgttcac atggtcaaaa tttcaccact gaaaccctgc acttagctag     5820

aacctcattt ttaaagatta acaacaggaa ataaattgta aaaaaggttt tctatacatg     5880

aaaaaaaaaa aaaaaaaa                                                   5898


<210>  118
<211>  1172
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Val Trp Arg Leu Val Leu Leu Ala Leu Trp Val Trp Pro Ser Thr 
1               5                   10                  15      


Gln Ala Gly His Gln Asp Lys Asp Thr Thr Phe Asp Leu Phe Ser Ile 
            20                  25                  30          


Ser Asn Ile Asn Arg Lys Thr Ile Gly Ala Lys Gln Phe Arg Gly Pro 
        35                  40                  45              


Asp Pro Gly Val Pro Ala Tyr Arg Phe Val Arg Phe Asp Tyr Ile Pro 
    50                  55                  60                  


Pro Val Asn Ala Asp Asp Leu Ser Lys Ile Thr Lys Ile Met Arg Gln 
65                  70                  75                  80  


Lys Glu Gly Phe Phe Leu Thr Ala Gln Leu Lys Gln Asp Gly Lys Ser 
                85                  90                  95      


Arg Gly Thr Leu Leu Ala Leu Glu Gly Pro Gly Leu Ser Gln Arg Gln 
            100                 105                 110         


Phe Glu Ile Val Ser Asn Gly Pro Ala Asp Thr Leu Asp Leu Thr Tyr 
        115                 120                 125             


Trp Ile Asp Gly Thr Arg His Val Val Ser Leu Glu Asp Val Gly Leu 
    130                 135                 140                 


Ala Asp Ser Gln Trp Lys Asn Val Thr Val Gln Val Ala Gly Glu Thr 
145                 150                 155                 160 


Tyr Ser Leu His Val Gly Cys Asp Leu Ile Asp Ser Phe Ala Leu Asp 
                165                 170                 175     


Glu Pro Phe Tyr Glu His Leu Gln Ala Glu Lys Ser Arg Met Tyr Val 
            180                 185                 190         


Ala Lys Gly Ser Ala Arg Glu Ser His Phe Arg Gly Leu Leu Gln Asn 
        195                 200                 205             


Val His Leu Val Phe Glu Asn Ser Val Glu Asp Ile Leu Ser Lys Lys 
    210                 215                 220                 


Gly Cys Gln Gln Gly Gln Gly Ala Glu Ile Asn Ala Ile Ser Glu Asn 
225                 230                 235                 240 


Thr Glu Thr Leu Arg Leu Gly Pro His Val Thr Thr Glu Tyr Val Gly 
                245                 250                 255     


Pro Ser Ser Glu Arg Arg Pro Glu Val Cys Glu Arg Ser Cys Glu Glu 
            260                 265                 270         


Leu Gly Asn Met Val Gln Glu Leu Ser Gly Leu His Val Leu Val Asn 
        275                 280                 285             


Gln Leu Ser Glu Asn Leu Lys Arg Val Ser Asn Asp Asn Gln Phe Leu 
    290                 295                 300                 


Trp Glu Leu Ile Gly Gly Pro Pro Lys Thr Arg Asn Met Ser Ala Cys 
305                 310                 315                 320 


Trp Gln Asp Gly Arg Phe Phe Ala Glu Asn Glu Thr Trp Val Val Asp 
                325                 330                 335     


Ser Cys Thr Thr Cys Thr Cys Lys Lys Phe Lys Thr Ile Cys His Gln 
            340                 345                 350         


Ile Thr Cys Pro Pro Ala Thr Cys Ala Ser Pro Ser Phe Val Glu Gly 
        355                 360                 365             


Glu Cys Cys Pro Ser Cys Leu His Ser Val Asp Gly Glu Glu Gly Trp 
    370                 375                 380                 


Ser Pro Trp Ala Glu Trp Thr Gln Cys Ser Val Thr Cys Gly Ser Gly 
385                 390                 395                 400 


Thr Gln Gln Arg Gly Arg Ser Cys Asp Val Thr Ser Asn Thr Cys Leu 
                405                 410                 415     


Gly Pro Ser Ile Gln Thr Arg Ala Cys Ser Leu Ser Lys Cys Asp Thr 
            420                 425                 430         


Arg Ile Arg Gln Asp Gly Gly Trp Ser His Trp Ser Pro Trp Ser Ser 
        435                 440                 445             


Cys Ser Val Thr Cys Gly Val Gly Asn Ile Thr Arg Ile Arg Leu Cys 
    450                 455                 460                 


Asn Ser Pro Val Pro Gln Met Gly Gly Lys Asn Cys Lys Gly Ser Gly 
465                 470                 475                 480 


Arg Glu Thr Lys Ala Cys Gln Gly Ala Pro Cys Pro Ile Asp Gly Arg 
                485                 490                 495     


Trp Ser Pro Trp Ser Pro Trp Ser Ala Cys Thr Val Thr Cys Ala Gly 
            500                 505                 510         


Gly Ile Arg Glu Arg Thr Arg Val Cys Asn Ser Pro Glu Pro Gln Tyr 
        515                 520                 525             


Gly Gly Lys Ala Cys Val Gly Asp Val Gln Glu Arg Gln Met Cys Asn 
    530                 535                 540                 


Lys Arg Ser Cys Pro Val Asp Gly Cys Leu Ser Asn Pro Cys Phe Pro 
545                 550                 555                 560 


Gly Ala Gln Cys Ser Ser Phe Pro Asp Gly Ser Trp Ser Cys Gly Ser 
                565                 570                 575     


Cys Pro Val Gly Phe Leu Gly Asn Gly Thr His Cys Glu Asp Leu Asp 
            580                 585                 590         


Glu Cys Ala Leu Val Pro Asp Ile Cys Phe Ser Thr Ser Lys Val Pro 
        595                 600                 605             


Arg Cys Val Asn Thr Gln Pro Gly Phe His Cys Leu Pro Cys Pro Pro 
    610                 615                 620                 


Arg Tyr Arg Gly Asn Gln Pro Val Gly Val Gly Leu Glu Ala Ala Lys 
625                 630                 635                 640 


Thr Glu Lys Gln Val Cys Glu Pro Glu Asn Pro Cys Lys Asp Lys Thr 
                645                 650                 655     


His Asn Cys His Lys His Ala Glu Cys Ile Tyr Leu Gly His Phe Ser 
            660                 665                 670         


Asp Pro Met Tyr Lys Cys Glu Cys Gln Thr Gly Tyr Ala Gly Asp Gly 
        675                 680                 685             


Leu Ile Cys Gly Glu Asp Ser Asp Leu Asp Gly Trp Pro Asn Leu Asn 
    690                 695                 700                 


Leu Val Cys Ala Thr Asn Ala Thr Tyr His Cys Ile Lys Asp Asn Cys 
705                 710                 715                 720 


Pro His Leu Pro Asn Ser Gly Gln Glu Asp Phe Asp Lys Asp Gly Ile 
                725                 730                 735     


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Thr Asp Glu 
            740                 745                 750         


Lys Asp Asn Cys Gln Leu Leu Phe Asn Pro Arg Gln Ala Asp Tyr Asp 
        755                 760                 765             


Lys Asp Glu Val Gly Asp Arg Cys Asp Asn Cys Pro Tyr Val His Asn 
    770                 775                 780                 


Pro Ala Gln Ile Asp Thr Asp Asn Asn Gly Glu Gly Asp Ala Cys Ser 
785                 790                 795                 800 


Val Asp Ile Asp Gly Asp Asp Val Phe Asn Glu Arg Asp Asn Cys Pro 
                805                 810                 815     


Tyr Val Tyr Asn Thr Asp Gln Arg Asp Thr Asp Gly Asp Gly Val Gly 
            820                 825                 830         


Asp His Cys Asp Asn Cys Pro Leu Val His Asn Pro Asp Gln Thr Asp 
        835                 840                 845             


Val Asp Asn Asp Leu Val Gly Asp Gln Cys Asp Asn Asn Glu Asp Ile 
    850                 855                 860                 


Asp Asp Asp Gly His Gln Asn Asn Gln Asp Asn Cys Pro Tyr Ile Ser 
865                 870                 875                 880 


Asn Ala Asn Gln Ala Asp His Asp Arg Asp Gly Gln Gly Asp Ala Cys 
                885                 890                 895     


Asp Pro Asp Asp Asp Asn Asp Gly Val Pro Asp Asp Arg Asp Asn Cys 
            900                 905                 910         


Arg Leu Val Phe Asn Pro Asp Gln Glu Asp Leu Asp Gly Asp Gly Arg 
        915                 920                 925             


Gly Asp Ile Cys Lys Asp Asp Phe Asp Asn Asp Asn Ile Pro Asp Ile 
    930                 935                 940                 


Asp Asp Val Cys Pro Glu Asn Asn Ala Ile Ser Glu Thr Asp Phe Arg 
945                 950                 955                 960 


Asn Phe Gln Met Val Pro Leu Asp Pro Lys Gly Thr Thr Gln Ile Asp 
                965                 970                 975     


Pro Asn Trp Val Ile Arg His Gln Gly Lys Glu Leu Val Gln Thr Ala 
            980                 985                 990         


Asn Ser Asp Pro Gly Ile Ala Val  Gly Phe Asp Glu Phe  Gly Ser Val 
        995                 1000                 1005             


Asp Phe  Ser Gly Thr Phe Tyr  Val Asn Thr Asp Arg  Asp Asp Asp 
    1010                 1015                 1020             


Tyr Ala  Gly Phe Val Phe Gly  Tyr Gln Ser Ser Ser  Arg Phe Tyr 
    1025                 1030                 1035             


Val Val  Met Trp Lys Gln Val  Thr Gln Thr Tyr Trp  Glu Asp Gln 
    1040                 1045                 1050             


Pro Thr  Arg Ala Tyr Gly Tyr  Ser Gly Val Ser Leu  Lys Val Val 
    1055                 1060                 1065             


Asn Ser  Thr Thr Gly Thr Gly  Glu His Leu Arg Asn  Ala Leu Trp 
    1070                 1075                 1080             


His Thr  Gly Asn Thr Pro Gly  Gln Val Arg Thr Leu  Trp His Asp 
    1085                 1090                 1095             


Pro Arg  Asn Ile Gly Trp Lys  Asp Tyr Thr Ala Tyr  Arg Trp His 
    1100                 1105                 1110             


Leu Thr  His Arg Pro Lys Thr  Gly Tyr Ile Arg Val  Leu Val His 
    1115                 1120                 1125             


Glu Gly  Lys Gln Val Met Ala  Asp Ser Gly Pro Ile  Tyr Asp Gln 
    1130                 1135                 1140             


Thr Tyr  Ala Gly Gly Arg Leu  Gly Leu Phe Val Phe  Ser Gln Glu 
    1145                 1150                 1155             


Met Val  Tyr Phe Ser Asp Leu  Lys Tyr Glu Cys Arg  Asp Ile 
    1160                 1165                 1170         


<210>  119
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  THBS2_forward primer

<400>  119
cagcacgcaa gctggtc                                                      17


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  THBS2_reverse primer

<400>  120
tgcggttgat gttgctgata                                                   20


<210>  121
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  THBS2 probe

<400>  121
accaggacaa agacacgacc ttcga                                             25


<210>  122
<211>  4193
<212>  DNA
<213>  Homo sapiens

<400>  122
cttcttctcg ctgagtctcc tcctcggctc tgacggtaca gtgatataat gatgatgggt       60

gtcacaaccc gcatttgaac ttgcaggcga gctgccccga gcctttctgg ggaagaactc      120

caggcgtgcg gacgcaacag ccgagaacat taggtgttgt ggacaggagc tgggaccaag      180

atcttcggcc agccccgcat cctcccgcat cttccagcac cgtcccgcac cctccgcatc      240

cttccccggg ccaccacgct tcctatgtga cccgcctggg caacgccgaa cccagtcgcg      300

cagcgctgca gtgaattttc cccccaaact gcaataagcc gccttccaag gccaagatgt      360

tcataaatat aaagagcatc ttatggatgt gttcaacctt aatagtaacc catgcgctac      420

ataaagtcaa agtgggaaaa agcccaccgg tgaggggctc cctctctgga aaagtcagcc      480

taccttgtca tttttcaacg atgcctactt tgccacccag ttacaacacc agtgaatttc      540

tccgcatcaa atggtctaag attgaagtgg acaaaaatgg aaaagatttg aaagagacta      600

ctgtccttgt ggcccaaaat ggaaatatca agattggtca ggactacaaa gggagagtgt      660

ctgtgcccac acatcccgag gctgtgggcg atgcctccct cactgtggtc aagctgctgg      720

caagtgatgc gggtctttac cgctgtgacg tcatgtacgg gattgaagac acacaagaca      780

cggtgtcact gactgtggat ggggttgtgt ttcactacag ggcggcaacc agcaggtaca      840

cactgaattt tgaggctgct cagaaggctt gtttggacgt tggggcagtc atagcaactc      900

cagagcagct ctttgctgcc tatgaagatg gatttgagca gtgtgacgca ggctggctgg      960

ctgatcagac tgtcagatat cccatccggg ctcccagagt aggctgttat ggagataaga     1020

tgggaaaggc aggagtcagg acttatggat tccgttctcc ccaggaaact tacgatgtgt     1080

attgttatgt ggatcatctg gatggtgatg tgttccacct cactgtcccc agtaaattca     1140

ccttcgagga ggctgcaaaa gagtgtgaaa accaggatgc caggctggca acagtggggg     1200

aactccaggc ggcatggagg aacggctttg accagtgcga ttacgggtgg ctgtcggatg     1260

ccagcgtgcg ccaccctgtg actgtggcca gggcccagtg tggaggtggt ctacttgggg     1320

tgagaaccct gtatcgtttt gagaaccaga caggcttccc tccccctgat agcagatttg     1380

atgcctactg ctttaaacga cctgatcgct gcaaaatgaa cccgtgcctt aacggaggca     1440

cctgttatcc tactgaaact tcctacgtat gcacctgtgt gccaggatac agcggagacc     1500

agtgtgaact tgattttgat gaatgtcact ctaatccctg tcgtaatgga gccacttgtg     1560

ttgatggttt taacacattc aggtgcctct gccttccaag ttatgttggt gcactttgtg     1620

agcaagatac cgagacatgt gactatggct ggcacaaatt ccaagggcag tgctacaaat     1680

actttgccca tcgacgcaca tgggatgcag ctgaacggga atgccgtctg cagggtgccc     1740

atctcacaag catcctgtct cacgaagaac aaatgtttgt taatcgtgtg ggccatgatt     1800

atcagtggat aggcctcaat gacaagatgt ttgagcatga cttccgttgg actgatggca     1860

gcacactgca atacgagaat tggagaccca accagccaga cagcttcttt tctgctggag     1920

aagactgtgt tgtaatcatt tggcatgaga atggccagtg gaatgatgtt ccctgcaatt     1980

accatctcac ctatacgtgc aagaaaggaa cagtcgcttg cggccagccc cctgttgtag     2040

aaaatgccaa gacctttgga aagatgaaac ctcgttatga aatcaactcc ctgattagat     2100

accactgcaa agatggtttc attcaacgtc accttccaac tatccggtgc ttaggaaatg     2160

gaagatgggc tatacctaaa attacctgca tgaacccatc tgcataccaa aggacttatt     2220

ctatgaaata ctttaaaaat tcctcatcag caaaggacaa ttcaataaat acatccaaac     2280

atgatcatcg ttggagccgg aggtggcagg agtcgaggcg ctgatcccta aaatggcgaa     2340

catgtgtttt catcatttca gccaaagtcc taacttcctg tgcctttcct atcacctcga     2400

gaagtaatta tcagttggtt tggatttttg gaccaccgtt cagtcatttt gggttgccgt     2460

gctcccaaaa cattttaaat gaaagtattg gcattcaaaa agacagcaga caaaatgaaa     2520

gaaaatgaga gcagaaagta agcatttcca gcctatctaa tttctttagt tttctatttg     2580

cctccagtgc agtccatttc ctaatgtata ccagcctact gtactattta aaatgctcaa     2640

tttcagcacc gatggccatg taaataagat gatttaatgt tgattttaat cctgtatata     2700

aaataaaaag tcacaatgag tttgggcata tttaatgatg attatggagc cttagaggtc     2760

tttaatcatt ggttcggctg cttttatgta gtttaggctg gaaatggttt cacttgctct     2820

ttgactgtca gcaagactga agatggcttt tcctggacag ctagaaaaca caaaatcttg     2880

taggtcattg cacctatctc agccataggt gcagtttgct tctacatgat gctaaaggct     2940

gcgaatggga tcctgatgga actaaggact ccaatgtcga actcttcttt gctgcattcc     3000

tttttcttca cttacaagaa aggcctgaat ggaggacttt tctgtaacca ggaacatttt     3060

ttaggggtca aagtgctaat aattaactca accaggtcta ctttttaatg gctttcataa     3120

cactaactca taaggttacc gatcaatgca tttcatacgg atatagacct agggctctgg     3180

agggtggggg attgttaaaa cacatgcaaa aaaaaaaaaa aaaaaaaaaa aagaaatttt     3240

gtatatataa ccattttaat cttttataaa gttttgaatg ttcatgtatg aatgctgcag     3300

ctgtgaagca tacataaata aatgaagtaa gccatactga tttaatttat tggatgttat     3360

tttccctaag acctgaaaat gaacatagta tgctagttat ttttcagtgt tagcctttta     3420

ctttcctcac acaatttgga atcatataat ataggtactt tgtccctgat taaataatgt     3480

gacggataga atgcatcaag tgtttattat gaaaagagtg gaaaagtata tagcttttag     3540

caaaaggtgt ttgcccattc taagaaatga gcgaatatat agaaatagtg tgggcatttc     3600

ttcctgttag gtggagtgta tgtgttgaca tttctcccca tctcttccca ctctgttttc     3660

tccccattat ttgaataaag tgactgctga agatgacttt gaatccttat ccacttaatt     3720

taatgtttaa agaaaaacct gtaatggaaa gtaagactcc ttccctaatt tcagtttaga     3780

gcaacttgaa gaagagtaga caaaaaataa aatgcacata gaaaaagaga aaaagggcac     3840

aaagggattg gcccaatatt gattcttttt ttataaaacc tcctttggct tagaaggaat     3900

gactctagct acaataatac acagtatgtt taagcaggtt cccttggttg ttgcattaaa     3960

tgtaatccac ctttaggtat tttagagcac agaacaacac tgtgttgatc tagtaggttt     4020

ctatttttcc tttctcttta caatgcacat aatactttcc tgtatttata tcataacgtg     4080

tatagtgtaa aatgtgaatg actttttttg tgaatgaaaa tctaaaatct ttgtaacttt     4140

ttatatctgc ttttgtttca ccaaagaaac ctaaaatcct tcttttacta cac            4193


<210>  123
<211>  9455
<212>  DNA
<213>  Homo sapiens

<400>  123
cttcttctcg ctgagtctcc tcctcggctc tgacggtaca gtgatataat gatgatgggt       60

gtcacaaccc gcatttgaac ttgcaggcga gctgccccga gcctttctgg ggaagaactc      120

caggcgtgcg gacgcaacag ccgagaacat taggtgttgt ggacaggagc tgggaccaag      180

atcttcggcc agccccgcat cctcccgcat cttccagcac cgtcccgcac cctccgcatc      240

cttccccggg ccaccacgct tcctatgtga cccgcctggg caacgccgaa cccagtcgcg      300

cagcgctgca gtgaattttc cccccaaact gcaataagcc gccttccaag gccaagatgt      360

tcataaatat aaagagcatc ttatggatgt gttcaacctt aatagtaacc catgcgctac      420

ataaagtcaa agtgggaaaa agcccaccgg tgaggggctc cctctctgga aaagtcagcc      480

taccttgtca tttttcaacg atgcctactt tgccacccag ttacaacacc agtgaatttc      540

tccgcatcaa atggtctaag attgaagtgg acaaaaatgg aaaagatttg aaagagacta      600

ctgtccttgt ggcccaaaat ggaaatatca agattggtca ggactacaaa gggagagtgt      660

ctgtgcccac acatcccgag gctgtgggcg atgcctccct cactgtggtc aagctgctgg      720

caagtgatgc gggtctttac cgctgtgacg tcatgtacgg gattgaagac acacaagaca      780

cggtgtcact gactgtggat ggggttgtgt ttcactacag ggcggcaacc agcaggtaca      840

cactgaattt tgaggctgct cagaaggctt gtttggacgt tggggcagtc atagcaactc      900

cagagcagct ctttgctgcc tatgaagatg gatttgagca gtgtgacgca ggctggctgg      960

ctgatcagac tgtcagatat cccatccggg ctcccagagt aggctgttat ggagataaga     1020

tgggaaaggc aggagtcagg acttatggat tccgttctcc ccaggaaact tacgatgtgt     1080

attgttatgt ggatcatctg gatggtgatg tgttccacct cactgtcccc agtaaattca     1140

ccttcgagga ggctgcaaaa gagtgtgaaa accaggatgc caggctggca acagtggggg     1200

aactccaggc ggcatggagg aacggctttg accagtgcga ttacgggtgg ctgtcggatg     1260

ccagcgtgcg ccaccctgtg actgtggcca gggcccagtg tggaggtggt ctacttgggg     1320

tgagaaccct gtatcgtttt gagaaccaga caggcttccc tccccctgat agcagatttg     1380

atgcctactg ctttaaacgt cgaatgagtg atttgagtgt aattggtcat ccaatagatt     1440

cagaatctaa agaagatgaa ccttgtagtg aagaaacaga tccagtgcat gatctaatgg     1500

ctgaaatttt acctgaattc cctgacataa ttgaaataga cctataccac agtgaagaaa     1560

atgaagaaga agaagaagag tgtgcaaatg ctactgatgt gacaaccacc ccatctgtgc     1620

agtacataaa tgggaagcat ctcgttacca ctgtgcccaa ggacccagaa gctgcagaag     1680

ctaggcgtgg ccagtttgaa agtgttgcac cttctcagaa tttctcggac agctctgaaa     1740

gtgatactca tccatttgta atagccaaaa cggaattgtc tactgctgtg caacctaatg     1800

aatctacaga aacaactgag tctcttgaag ttacatggaa gcctgagact taccctgaaa     1860

catcagaaca tttttcaggt ggtgagcctg atgttttccc cacagtccca ttccatgagg     1920

aatttgaaag tggaacagcc aaaaaagggg cagaatcagt cacagagaga gatactgaag     1980

ttggtcatca ggcacatgaa catactgaac ctgtatctct gtttcctgaa gagtcttcag     2040

gagagattgc cattgaccaa gaatctcaga aaatagcctt tgcaagggct acagaagtaa     2100

catttggtga agaggtagaa aaaagtactt ctgtcacata cactcccact atagttccaa     2160

gttctgcatc agcatatgtt tcagaggaag aagcagttac cctaatagga aatccttggc     2220

cagatgacct gttgtctacc aaagaaagct gggtagaagc aactcctaga caagttgtag     2280

agctctcagg gagttcttcg attccaatta cagaaggctc tggagaagca gaagaagatg     2340

aagatacaat gttcaccatg gtaactgatt tatcacagag aaatactact gatacactca     2400

ttactttaga cactagcagg ataatcacag aaagcttttt tgaggttcct gcaaccacca     2460

tttatccagt ttctgaacaa ccttctgcaa aagtggtgcc taccaagttt gtaagtgaaa     2520

cagacacttc tgagtggatt tccagtacca ctgttgagga aaagaaaagg aaggaggagg     2580

agggaactac aggtacggct tctacatttg aggtatattc atctacacag agatcggatc     2640

aattaatttt accctttgaa ttagaaagtc caaatgtagc tacatctagt gattcaggta     2700

ccaggaaaag ttttatgtcc ttgacaacac caacacagtc tgaaagggaa atgacagatt     2760

ctactcctgt ctttacagaa acaaatacat tagaaaattt gggggcacag accactgagc     2820

acagcagtat ccatcaacct ggggttcagg aagggctgac cactctccca cgtagtcctg     2880

cctctgtctt tatggagcag ggctctggag aagctgctgc cgacccagaa accaccactg     2940

tttcttcatt ttcattaaac gtagagtatg caattcaagc cgaaaaggaa gtagctggca     3000

ctttgtctcc gcatgtggaa actacattct ccactgagcc aacaggactg gttttgagta     3060

cagtaatgga cagagtagtt gctgaaaata taacccaaac atccagggaa atagtgattt     3120

cagagcgatt aggagaacca aattatgggg cagaaataag gggcttttcc acaggttttc     3180

ctttggagga agatttcagt ggtgacttta gagaatactc aacagtgtct catcccatag     3240

caaaagaaga aacggtaatg atggaaggct ctggagatgc agcatttagg gacacccaga     3300

cttcaccatc tacagtacct acttcagttc acatcagtca catatctgac tcagaaggac     3360

ccagtagcac catggtcagc acttcagcct tcccctggga agagtttaca tcctcagctg     3420

agggctcagg tgagcaactg gtcacagtca gcagctctgt tgttccagtg cttcccagtg     3480

ctgtgcaaaa gttttctggt acagcttcct ccattatcga cgaaggattg ggagaagtgg     3540

gtactgtcaa tgaaattgat agaagatcca ccattttacc aacagcagaa gtggaaggta     3600

cgaaagctcc agtagagaag gaggaagtaa aggtcagtgg cacagtttca acaaactttc     3660

cccaaactat agagccagcc aaattatggt ctaggcaaga agtcaaccct gtaagacaag     3720

aaattgaaag tgaaacaaca tcagaggaac aaattcaaga agaaaagtca tttgaatccc     3780

ctcaaaactc tcctgcaaca gaacaaacaa tctttgattc acagacattt actgaaactg     3840

aactcaaaac cacagattat tctgtactaa caacaaagaa aacttacagt gatgataaag     3900

aaatgaagga ggaagacact tctttagtta acatgtctac tccagatcca gatgcaaatg     3960

gcttggaatc ttacacaact ctccctgaag ctactgaaaa gtcacatttt ttcttagcta     4020

ctgcattagt aactgaatct ataccagctg aacatgtagt cacagattca ccaatcaaaa     4080

aggaagaaag tacaaaacat tttccgaaag gcatgagacc aacaattcaa gagtcagata     4140

ctgagctctt attctctgga ctgggatcag gagaagaagt tttacctact ctaccaacag     4200

agtcagtgaa ttttactgaa gtggaacaaa tcaataacac attatatccc cacacttctc     4260

aagtggaaag tacctcaagt gacaaaattg aagactttaa cagaatggaa aatgtggcaa     4320

aagaagttgg accactcgta tctcaaacag acatctttga aggtagtggg tcagtaacca     4380

gcacaacatt aatagaaatt ttaagtgaca ctggagcaga aggacccacg gtggcacctc     4440

tccctttctc cacggacatc ggacatcctc aaaatcagac tgtcaggtgg gcagaagaaa     4500

tccagactag tagaccacaa accataactg aacaagactc taacaagaat tcttcaacag     4560

cagaaattaa cgaaacaaca acctcatcta ctgattttct ggctagagct tatggttttg     4620

aaatggccaa agaatttgtt acatcagcac caaaaccatc tgacttgtat tatgaacctt     4680

ctggagaagg atctggagaa gtggatattg ttgattcatt tcacacttct gcaactactc     4740

aggcaaccag acaagaaagc agcaccacat ttgtttctga tgggtccctg gaaaaacatc     4800

ctgaggtgcc aagcgctaaa gctgttactg ctgatggatt cccaacagtt tcagtgatgc     4860

tgcctcttca ttcagagcag aacaaaagct cccctgatcc aactagcaca ctgtcaaata     4920

cagtgtcata tgagaggtcc acagacggta gtttccaaga ccgtttcagg gaattcgagg     4980

attccacctt aaaacctaac agaaaaaaac ccactgaaaa tattatcata gacctggaca     5040

aagaggacaa ggatttaata ttgacaatta cagagagtac catccttgaa attctacctg     5100

agctgacatc ggataaaaat actatcatag atattgatca tactaaacct gtgtatgaag     5160

acattcttgg aatgcaaaca gatatagata cagaggtacc atcagaacca catgacagta     5220

atgatgaaag taatgatgac agcactcaag ttcaagagat ctatgaggca gctgtcaacc     5280

tttctttaac tgaggaaaca tttgagggct ctgctgatgt tctggctagc tacactcagg     5340

caacacatga tgaatcaatg acttatgaag atagaagcca actagatcac atgggctttc     5400

acttcacaac tgggatccct gctcctagca cagaaacaga attagacgtt ttacttccca     5460

cggcaacatc cctgccaatt cctcgtaagt ctgccacagt tattccagag attgaaggaa     5520

taaaagctga agcaaaagcc ctggatgaca tgtttgaatc aagcactttg tctgatggtc     5580

aagctattgc agaccaaagt gaaataatac caacattggg ccaatttgaa aggactcagg     5640

aggagtatga agacaaaaaa catgctggtc cttcttttca gccagaattc tcttcaggag     5700

ctgaggaggc attagtagac catactccct atctaagtat tgctactacc caccttatgg     5760

atcagagtgt aacagaggtg cctgatgtga tggaaggatc caatccccca tattacactg     5820

atacaacatt agcagtttca acatttgcga agttgtcttc tcagacacca tcatctcccc     5880

tcactatcta ctcaggcagt gaagcctctg gacacacaga gatcccccag cccagtgctc     5940

tgccaggaat agacgtcggc tcatctgtaa tgtccccaca ggattctttt aaggaaattc     6000

atgtaaatat tgaagcgact ttcaaaccat caagtgagga ataccttcac ataactgagc     6060

ctccctcttt atctcctgac acaaaattag aaccttcaga agatgatggt aaacctgagt     6120

tattagaaga aatggaagct tctcccacag aacttattgc tgtggaagga actgagattc     6180

tccaagattt ccaaaacaaa accgatggtc aagtttctgg agaagcaatc aagatgtttc     6240

ccaccattaa aacacctgag gctggaactg ttattacaac tgccgatgaa attgaattag     6300

aaggtgctac acagtggcca cactctactt ctgcttctgc cacctatggg gtcgaggcag     6360

gtgtggtgcc ttggctaagt ccacagactt ctgagaggcc cacgctttct tcttctccag     6420

aaataaaccc tgaaactcaa gcagctttaa tcagagggca ggattccacg atagcagcat     6480

cagaacagca agtggcagcg agaattcttg attccaatga tcaggcaaca gtaaaccctg     6540

tggaatttaa tactgaggtt gcaacaccac cattttccct tctggagact tctaatgaaa     6600

cagatttcct gattggcatt aatgaagagt cagtggaagg cacggcaatc tatttaccag     6660

gacctgatcg ctgcaaaatg aacccgtgcc ttaacggagg cacctgttat cctactgaaa     6720

cttcctacgt atgcacctgt gtgccaggat acagcggaga ccagtgtgaa cttgattttg     6780

atgaatgtca ctctaatccc tgtcgtaatg gagccacttg tgttgatggt tttaacacat     6840

tcaggtgcct ctgccttcca agttatgttg gtgcactttg tgagcaagat accgagacat     6900

gtgactatgg ctggcacaaa ttccaagggc agtgctacaa atactttgcc catcgacgca     6960

catgggatgc agctgaacgg gaatgccgtc tgcagggtgc ccatctcaca agcatcctgt     7020

ctcacgaaga acaaatgttt gttaatcgtg tgggccatga ttatcagtgg ataggcctca     7080

atgacaagat gtttgagcat gacttccgtt ggactgatgg cagcacactg caatacgaga     7140

attggagacc caaccagcca gacagcttct tttctgctgg agaagactgt gttgtaatca     7200

tttggcatga gaatggccag tggaatgatg ttccctgcaa ttaccatctc acctatacgt     7260

gcaagaaagg aacagtcgct tgcggccagc cccctgttgt agaaaatgcc aagacctttg     7320

gaaagatgaa acctcgttat gaaatcaact ccctgattag ataccactgc aaagatggtt     7380

tcattcaacg tcaccttcca actatccggt gcttaggaaa tggaagatgg gctataccta     7440

aaattacctg catgaaccca tctgcatacc aaaggactta ttctatgaaa tactttaaaa     7500

attcctcatc agcaaaggac aattcaataa atacatccaa acatgatcat cgttggagcc     7560

ggaggtggca ggagtcgagg cgctgatccc taaaatggcg aacatgtgtt ttcatcattt     7620

cagccaaagt cctaacttcc tgtgcctttc ctatcacctc gagaagtaat tatcagttgg     7680

tttggatttt tggaccaccg ttcagtcatt ttgggttgcc gtgctcccaa aacattttaa     7740

atgaaagtat tggcattcaa aaagacagca gacaaaatga aagaaaatga gagcagaaag     7800

taagcatttc cagcctatct aatttcttta gttttctatt tgcctccagt gcagtccatt     7860

tcctaatgta taccagccta ctgtactatt taaaatgctc aatttcagca ccgatggcca     7920

tgtaaataag atgatttaat gttgatttta atcctgtata taaaataaaa agtcacaatg     7980

agtttgggca tatttaatga tgattatgga gccttagagg tctttaatca ttggttcggc     8040

tgcttttatg tagtttaggc tggaaatggt ttcacttgct ctttgactgt cagcaagact     8100

gaagatggct tttcctggac agctagaaaa cacaaaatct tgtaggtcat tgcacctatc     8160

tcagccatag gtgcagtttg cttctacatg atgctaaagg ctgcgaatgg gatcctgatg     8220

gaactaagga ctccaatgtc gaactcttct ttgctgcatt cctttttctt cacttacaag     8280

aaaggcctga atggaggact tttctgtaac caggaacatt ttttaggggt caaagtgcta     8340

ataattaact caaccaggtc tactttttaa tggctttcat aacactaact cataaggtta     8400

ccgatcaatg catttcatac ggatatagac ctagggctct ggagggtggg ggattgttaa     8460

aacacatgca aaaaaaaaaa aaaaaaaaaa aaaagaaatt ttgtatatat aaccatttta     8520

atcttttata aagttttgaa tgttcatgta tgaatgctgc agctgtgaag catacataaa     8580

taaatgaagt aagccatact gatttaattt attggatgtt attttcccta agacctgaaa     8640

atgaacatag tatgctagtt atttttcagt gttagccttt tactttcctc acacaatttg     8700

gaatcatata atataggtac tttgtccctg attaaataat gtgacggata gaatgcatca     8760

agtgtttatt atgaaaagag tggaaaagta tatagctttt agcaaaaggt gtttgcccat     8820

tctaagaaat gagcgaatat atagaaatag tgtgggcatt tcttcctgtt aggtggagtg     8880

tatgtgttga catttctccc catctcttcc cactctgttt tctccccatt atttgaataa     8940

agtgactgct gaagatgact ttgaatcctt atccacttaa tttaatgttt aaagaaaaac     9000

ctgtaatgga aagtaagact ccttccctaa tttcagttta gagcaacttg aagaagagta     9060

gacaaaaaat aaaatgcaca tagaaaaaga gaaaaagggc acaaagggat tggcccaata     9120

ttgattcttt ttttataaaa cctcctttgg cttagaagga atgactctag ctacaataat     9180

acacagtatg tttaagcagg ttcccttggt tgttgcatta aatgtaatcc acctttaggt     9240

attttagagc acagaacaac actgtgttga tctagtaggt ttctattttt cctttctctt     9300

tacaatgcac ataatacttt cctgtattta tatcataacg tgtatagtgt aaaatgtgaa     9360

tgactttttt tgtgaatgaa aatctaaaat ctttgtaact ttttatatct gcttttgttt     9420

caccaaagaa acctaaaatc cttcttttac tacac                                9455


<210>  124
<211>  7154
<212>  DNA
<213>  Homo sapiens

<400>  124
cttcttctcg ctgagtctcc tcctcggctc tgacggtaca gtgatataat gatgatgggt       60

gtcacaaccc gcatttgaac ttgcaggcga gctgccccga gcctttctgg ggaagaactc      120

caggcgtgcg gacgcaacag ccgagaacat taggtgttgt ggacaggagc tgggaccaag      180

atcttcggcc agccccgcat cctcccgcat cttccagcac cgtcccgcac cctccgcatc      240

cttccccggg ccaccacgct tcctatgtga cccgcctggg caacgccgaa cccagtcgcg      300

cagcgctgca gtgaattttc cccccaaact gcaataagcc gccttccaag gccaagatgt      360

tcataaatat aaagagcatc ttatggatgt gttcaacctt aatagtaacc catgcgctac      420

ataaagtcaa agtgggaaaa agcccaccgg tgaggggctc cctctctgga aaagtcagcc      480

taccttgtca tttttcaacg atgcctactt tgccacccag ttacaacacc agtgaatttc      540

tccgcatcaa atggtctaag attgaagtgg acaaaaatgg aaaagatttg aaagagacta      600

ctgtccttgt ggcccaaaat ggaaatatca agattggtca ggactacaaa gggagagtgt      660

ctgtgcccac acatcccgag gctgtgggcg atgcctccct cactgtggtc aagctgctgg      720

caagtgatgc gggtctttac cgctgtgacg tcatgtacgg gattgaagac acacaagaca      780

cggtgtcact gactgtggat ggggttgtgt ttcactacag ggcggcaacc agcaggtaca      840

cactgaattt tgaggctgct cagaaggctt gtttggacgt tggggcagtc atagcaactc      900

cagagcagct ctttgctgcc tatgaagatg gatttgagca gtgtgacgca ggctggctgg      960

ctgatcagac tgtcagatat cccatccggg ctcccagagt aggctgttat ggagataaga     1020

tgggaaaggc aggagtcagg acttatggat tccgttctcc ccaggaaact tacgatgtgt     1080

attgttatgt ggatcatctg gatggtgatg tgttccacct cactgtcccc agtaaattca     1140

ccttcgagga ggctgcaaaa gagtgtgaaa accaggatgc caggctggca acagtggggg     1200

aactccaggc ggcatggagg aacggctttg accagtgcga ttacgggtgg ctgtcggatg     1260

ccagcgtgcg ccaccctgtg actgtggcca gggcccagtg tggaggtggt ctacttgggg     1320

tgagaaccct gtatcgtttt gagaaccaga caggcttccc tccccctgat agcagatttg     1380

atgcctactg ctttaaacct aaagaggcta caaccatcga tttgagtatc ctcgcagaaa     1440

ctgcatcacc cagtttatcc aaagaaccac aaatggtttc tgatagaact acaccaatca     1500

tccctttagt tgatgaatta cctgtcattc caacagagtt ccctcccgtg ggaaatattg     1560

tcagttttga acagaaagcc acagtccaac ctcaggctat cacagatagt ttagccacca     1620

aattacccac acctactggc agtaccaaga agccctggga tatggatgac tactcacctt     1680

ctgcttcagg acctcttgga aagctagaca tatcagaaat taaggaagaa gtgctccaga     1740

gtacaactgg cgtctctcat tatgctacgg attcatggga tggtgtcgtg gaagataaac     1800

aaacacaaga atcggttaca cagattgaac aaatagaagt gggtcctttg gtaacatcta     1860

tggaaatctt aaagcacatt ccttccaagg aattccctgt aactgaaaca ccattggtaa     1920

ctgcaagaat gatcctggaa tccaaaactg aaaagaaaat ggtaagcact gtttctgaat     1980

tggtaaccac aggtcactat ggattcacct tgggagaaga ggatgatgaa gacagaacac     2040

ttacagttgg atctgatgag agcaccttga tctttgacca aattcctgaa gtcattacgg     2100

tgtcaaagac ttcagaagac accatccaca ctcatttaga agacttggag tcagtctcag     2160

catccacaac tgtttcccct ttaattatgc ctgataataa tggatcatcc atggatgact     2220

gggaagagag acaaactagt ggtaggataa cggaagagtt tcttggcaaa tatctgtcta     2280

ctacaccttt tccatcacag catcgtacag aaatagaatt gtttccttat tctggtgata     2340

aaatattagt agagggaatt tccacagtta tttatccttc tctacaaaca gaaatgacac     2400

atagaagaga aagaacagaa acactaatac cagagatgag aacagatact tatacagatg     2460

aaatacaaga agagatcact aaaagtccat ttatgggaaa aacagaagaa gaagtcttct     2520

ctgggatgaa actctctaca tctctctcag agccaattca tgttacagag tcttctgtgg     2580

aaatgaccaa gtcttttgat ttcccaacat tgataacaaa gttaagtgca gagccaacag     2640

aagtaagaga tatggaggaa gactttacag caactccagg tactacaaaa tatgatgaaa     2700

atattacaac agtgcttttg gcccatggta ctttaagtgt tgaagcagcc actgtatcaa     2760

aatggtcatg ggatgaagat aatacaacat ccaagccttt agagtctaca gaaccttcag     2820

cctcttcaaa attgccccct gccttactca caactgtggg gatgaatgga aaggataaag     2880

acatcccaag tttcactgaa gatggagcag atgaatttac tcttattcca gatagtactc     2940

aaaagcagtt agaggaggtt actgatgaag acatagcagc ccatggaaaa ttcacaatta     3000

gatttcagcc aactacatca actggtattg cagaaaagtc aactttgaga gattctacaa     3060

ctgaagaaaa agttccacct atcacaagca ctgaaggcca agtttatgca accatggaag     3120

gaagtgcttt gggtgaagta gaagatgtgg acctctctaa gccagtatct actgttcccc     3180

aatttgcaca cacttcagag gtggaaggat tagcatttgt tagttatagt agcacccaag     3240

agcctactac ttatgtagac tcttcccata ccattcctct ttctgtaatt cccaagacag     3300

actggggagt gttagtacct tctgttccat cagaagatga agttctaggt gaaccctctc     3360

aagacatact tgtcattgat cagactcgcc ttgaagcgac tatttctcca gaaactatga     3420

gaacaacaaa aatcacagag ggaacaactc aggaagaatt cccttggaaa gaacagactg     3480

cagagaaacc agttcctgct ctcagttcta cagcttggac tcccaaggag gcagtaacac     3540

cactggatga acaagagggc gatggatcag catatacagt ctctgaagat gaattgttga     3600

caggttctga gagggtccca gttttagaaa caactccagt tggaaaaatt gatcacagtg     3660

tgtcttatcc accaggtgct gtaactgagc acaaagtgaa aacagatgaa gtggtaacac     3720

taacaccacg cattgggcca aaagtatctt taagtccagg gcctgaacaa aaatatgaaa     3780

cagaaggtag tagtacaaca ggatttacat catctttgag tccttttagt acccacatta     3840

cccagcttat ggaagaaacc actactgaga aaacatccct agaggatatt gatttaggct     3900

caggattatt tgaaaagccc aaagccacag aactcataga attttcaaca atcaaagtca     3960

cagttccaag tgatattacc actgccttca gttcagtaga cagacttcac acaacttcag     4020

cattcaagcc atcttccgcg atcactaaga aaccacctct catcgacagg gaacctggtg     4080

aagaaacaac cagtgacatg gtaatcattg gagaatcaac atctcatgtt cctcccacta     4140

cccttgaaga tattgtagcc aaggaaacag aaaccgatat tgatagagag tatttcacga     4200

cttcaagtcc tcctgctaca cagccaacaa gaccacccac tgtggaagac aaagaggcct     4260

ttggacctca ggcgctttct acgccacagc ccccagcaag cacaaaattt caccctgaca     4320

ttaatgttta tattattgag gtcagagaaa ataagacagg acctgatcgc tgcaaaatga     4380

acccgtgcct taacggaggc acctgttatc ctactgaaac ttcctacgta tgcacctgtg     4440

tgccaggata cagcggagac cagtgtgaac ttgattttga tgaatgtcac tctaatccct     4500

gtcgtaatgg agccacttgt gttgatggtt ttaacacatt caggtgcctc tgccttccaa     4560

gttatgttgg tgcactttgt gagcaagata ccgagacatg tgactatggc tggcacaaat     4620

tccaagggca gtgctacaaa tactttgccc atcgacgcac atgggatgca gctgaacggg     4680

aatgccgtct gcagggtgcc catctcacaa gcatcctgtc tcacgaagaa caaatgtttg     4740

ttaatcgtgt gggccatgat tatcagtgga taggcctcaa tgacaagatg tttgagcatg     4800

acttccgttg gactgatggc agcacactgc aatacgagaa ttggagaccc aaccagccag     4860

acagcttctt ttctgctgga gaagactgtg ttgtaatcat ttggcatgag aatggccagt     4920

ggaatgatgt tccctgcaat taccatctca cctatacgtg caagaaagga acagtcgctt     4980

gcggccagcc ccctgttgta gaaaatgcca agacctttgg aaagatgaaa cctcgttatg     5040

aaatcaactc cctgattaga taccactgca aagatggttt cattcaacgt caccttccaa     5100

ctatccggtg cttaggaaat ggaagatggg ctatacctaa aattacctgc atgaacccat     5160

ctgcatacca aaggacttat tctatgaaat actttaaaaa ttcctcatca gcaaaggaca     5220

attcaataaa tacatccaaa catgatcatc gttggagccg gaggtggcag gagtcgaggc     5280

gctgatccct aaaatggcga acatgtgttt tcatcatttc agccaaagtc ctaacttcct     5340

gtgcctttcc tatcacctcg agaagtaatt atcagttggt ttggattttt ggaccaccgt     5400

tcagtcattt tgggttgccg tgctcccaaa acattttaaa tgaaagtatt ggcattcaaa     5460

aagacagcag acaaaatgaa agaaaatgag agcagaaagt aagcatttcc agcctatcta     5520

atttctttag ttttctattt gcctccagtg cagtccattt cctaatgtat accagcctac     5580

tgtactattt aaaatgctca atttcagcac cgatggccat gtaaataaga tgatttaatg     5640

ttgattttaa tcctgtatat aaaataaaaa gtcacaatga gtttgggcat atttaatgat     5700

gattatggag ccttagaggt ctttaatcat tggttcggct gcttttatgt agtttaggct     5760

ggaaatggtt tcacttgctc tttgactgtc agcaagactg aagatggctt ttcctggaca     5820

gctagaaaac acaaaatctt gtaggtcatt gcacctatct cagccatagg tgcagtttgc     5880

ttctacatga tgctaaaggc tgcgaatggg atcctgatgg aactaaggac tccaatgtcg     5940

aactcttctt tgctgcattc ctttttcttc acttacaaga aaggcctgaa tggaggactt     6000

ttctgtaacc aggaacattt tttaggggtc aaagtgctaa taattaactc aaccaggtct     6060

actttttaat ggctttcata acactaactc ataaggttac cgatcaatgc atttcatacg     6120

gatatagacc tagggctctg gagggtgggg gattgttaaa acacatgcaa aaaaaaaaaa     6180

aaaaaaaaaa aaagaaattt tgtatatata accattttaa tcttttataa agttttgaat     6240

gttcatgtat gaatgctgca gctgtgaagc atacataaat aaatgaagta agccatactg     6300

atttaattta ttggatgtta ttttccctaa gacctgaaaa tgaacatagt atgctagtta     6360

tttttcagtg ttagcctttt actttcctca cacaatttgg aatcatataa tataggtact     6420

ttgtccctga ttaaataatg tgacggatag aatgcatcaa gtgtttatta tgaaaagagt     6480

ggaaaagtat atagctttta gcaaaaggtg tttgcccatt ctaagaaatg agcgaatata     6540

tagaaatagt gtgggcattt cttcctgtta ggtggagtgt atgtgttgac atttctcccc     6600

atctcttccc actctgtttt ctccccatta tttgaataaa gtgactgctg aagatgactt     6660

tgaatcctta tccacttaat ttaatgttta aagaaaaacc tgtaatggaa agtaagactc     6720

cttccctaat ttcagtttag agcaacttga agaagagtag acaaaaaata aaatgcacat     6780

agaaaaagag aaaaagggca caaagggatt ggcccaatat tgattctttt tttataaaac     6840

ctcctttggc ttagaaggaa tgactctagc tacaataata cacagtatgt ttaagcaggt     6900

tcccttggtt gttgcattaa atgtaatcca cctttaggta ttttagagca cagaacaaca     6960

ctgtgttgat ctagtaggtt tctatttttc ctttctcttt acaatgcaca taatactttc     7020

ctgtatttat atcataacgt gtatagtgta aaatgtgaat gacttttttt gtgaatgaaa     7080

atctaaaatc tttgtaactt tttatatctg cttttgtttc accaaagaaa cctaaaatcc     7140

ttcttttact acac                                                       7154


<210>  125
<211>  12416
<212>  DNA
<213>  Homo sapiens

<400>  125
cttcttctcg ctgagtctcc tcctcggctc tgacggtaca gtgatataat gatgatgggt       60

gtcacaaccc gcatttgaac ttgcaggcga gctgccccga gcctttctgg ggaagaactc      120

caggcgtgcg gacgcaacag ccgagaacat taggtgttgt ggacaggagc tgggaccaag      180

atcttcggcc agccccgcat cctcccgcat cttccagcac cgtcccgcac cctccgcatc      240

cttccccggg ccaccacgct tcctatgtga cccgcctggg caacgccgaa cccagtcgcg      300

cagcgctgca gtgaattttc cccccaaact gcaataagcc gccttccaag gccaagatgt      360

tcataaatat aaagagcatc ttatggatgt gttcaacctt aatagtaacc catgcgctac      420

ataaagtcaa agtgggaaaa agcccaccgg tgaggggctc cctctctgga aaagtcagcc      480

taccttgtca tttttcaacg atgcctactt tgccacccag ttacaacacc agtgaatttc      540

tccgcatcaa atggtctaag attgaagtgg acaaaaatgg aaaagatttg aaagagacta      600

ctgtccttgt ggcccaaaat ggaaatatca agattggtca ggactacaaa gggagagtgt      660

ctgtgcccac acatcccgag gctgtgggcg atgcctccct cactgtggtc aagctgctgg      720

caagtgatgc gggtctttac cgctgtgacg tcatgtacgg gattgaagac acacaagaca      780

cggtgtcact gactgtggat ggggttgtgt ttcactacag ggcggcaacc agcaggtaca      840

cactgaattt tgaggctgct cagaaggctt gtttggacgt tggggcagtc atagcaactc      900

cagagcagct ctttgctgcc tatgaagatg gatttgagca gtgtgacgca ggctggctgg      960

ctgatcagac tgtcagatat cccatccggg ctcccagagt aggctgttat ggagataaga     1020

tgggaaaggc aggagtcagg acttatggat tccgttctcc ccaggaaact tacgatgtgt     1080

attgttatgt ggatcatctg gatggtgatg tgttccacct cactgtcccc agtaaattca     1140

ccttcgagga ggctgcaaaa gagtgtgaaa accaggatgc caggctggca acagtggggg     1200

aactccaggc ggcatggagg aacggctttg accagtgcga ttacgggtgg ctgtcggatg     1260

ccagcgtgcg ccaccctgtg actgtggcca gggcccagtg tggaggtggt ctacttgggg     1320

tgagaaccct gtatcgtttt gagaaccaga caggcttccc tccccctgat agcagatttg     1380

atgcctactg ctttaaacct aaagaggcta caaccatcga tttgagtatc ctcgcagaaa     1440

ctgcatcacc cagtttatcc aaagaaccac aaatggtttc tgatagaact acaccaatca     1500

tccctttagt tgatgaatta cctgtcattc caacagagtt ccctcccgtg ggaaatattg     1560

tcagttttga acagaaagcc acagtccaac ctcaggctat cacagatagt ttagccacca     1620

aattacccac acctactggc agtaccaaga agccctggga tatggatgac tactcacctt     1680

ctgcttcagg acctcttgga aagctagaca tatcagaaat taaggaagaa gtgctccaga     1740

gtacaactgg cgtctctcat tatgctacgg attcatggga tggtgtcgtg gaagataaac     1800

aaacacaaga atcggttaca cagattgaac aaatagaagt gggtcctttg gtaacatcta     1860

tggaaatctt aaagcacatt ccttccaagg aattccctgt aactgaaaca ccattggtaa     1920

ctgcaagaat gatcctggaa tccaaaactg aaaagaaaat ggtaagcact gtttctgaat     1980

tggtaaccac aggtcactat ggattcacct tgggagaaga ggatgatgaa gacagaacac     2040

ttacagttgg atctgatgag agcaccttga tctttgacca aattcctgaa gtcattacgg     2100

tgtcaaagac ttcagaagac accatccaca ctcatttaga agacttggag tcagtctcag     2160

catccacaac tgtttcccct ttaattatgc ctgataataa tggatcatcc atggatgact     2220

gggaagagag acaaactagt ggtaggataa cggaagagtt tcttggcaaa tatctgtcta     2280

ctacaccttt tccatcacag catcgtacag aaatagaatt gtttccttat tctggtgata     2340

aaatattagt agagggaatt tccacagtta tttatccttc tctacaaaca gaaatgacac     2400

atagaagaga aagaacagaa acactaatac cagagatgag aacagatact tatacagatg     2460

aaatacaaga agagatcact aaaagtccat ttatgggaaa aacagaagaa gaagtcttct     2520

ctgggatgaa actctctaca tctctctcag agccaattca tgttacagag tcttctgtgg     2580

aaatgaccaa gtcttttgat ttcccaacat tgataacaaa gttaagtgca gagccaacag     2640

aagtaagaga tatggaggaa gactttacag caactccagg tactacaaaa tatgatgaaa     2700

atattacaac agtgcttttg gcccatggta ctttaagtgt tgaagcagcc actgtatcaa     2760

aatggtcatg ggatgaagat aatacaacat ccaagccttt agagtctaca gaaccttcag     2820

cctcttcaaa attgccccct gccttactca caactgtggg gatgaatgga aaggataaag     2880

acatcccaag tttcactgaa gatggagcag atgaatttac tcttattcca gatagtactc     2940

aaaagcagtt agaggaggtt actgatgaag acatagcagc ccatggaaaa ttcacaatta     3000

gatttcagcc aactacatca actggtattg cagaaaagtc aactttgaga gattctacaa     3060

ctgaagaaaa agttccacct atcacaagca ctgaaggcca agtttatgca accatggaag     3120

gaagtgcttt gggtgaagta gaagatgtgg acctctctaa gccagtatct actgttcccc     3180

aatttgcaca cacttcagag gtggaaggat tagcatttgt tagttatagt agcacccaag     3240

agcctactac ttatgtagac tcttcccata ccattcctct ttctgtaatt cccaagacag     3300

actggggagt gttagtacct tctgttccat cagaagatga agttctaggt gaaccctctc     3360

aagacatact tgtcattgat cagactcgcc ttgaagcgac tatttctcca gaaactatga     3420

gaacaacaaa aatcacagag ggaacaactc aggaagaatt cccttggaaa gaacagactg     3480

cagagaaacc agttcctgct ctcagttcta cagcttggac tcccaaggag gcagtaacac     3540

cactggatga acaagagggc gatggatcag catatacagt ctctgaagat gaattgttga     3600

caggttctga gagggtccca gttttagaaa caactccagt tggaaaaatt gatcacagtg     3660

tgtcttatcc accaggtgct gtaactgagc acaaagtgaa aacagatgaa gtggtaacac     3720

taacaccacg cattgggcca aaagtatctt taagtccagg gcctgaacaa aaatatgaaa     3780

cagaaggtag tagtacaaca ggatttacat catctttgag tccttttagt acccacatta     3840

cccagcttat ggaagaaacc actactgaga aaacatccct agaggatatt gatttaggct     3900

caggattatt tgaaaagccc aaagccacag aactcataga attttcaaca atcaaagtca     3960

cagttccaag tgatattacc actgccttca gttcagtaga cagacttcac acaacttcag     4020

cattcaagcc atcttccgcg atcactaaga aaccacctct catcgacagg gaacctggtg     4080

aagaaacaac cagtgacatg gtaatcattg gagaatcaac atctcatgtt cctcccacta     4140

cccttgaaga tattgtagcc aaggaaacag aaaccgatat tgatagagag tatttcacga     4200

cttcaagtcc tcctgctaca cagccaacaa gaccacccac tgtggaagac aaagaggcct     4260

ttggacctca ggcgctttct acgccacagc ccccagcaag cacaaaattt caccctgaca     4320

ttaatgttta tattattgag gtcagagaaa ataagacagg tcgaatgagt gatttgagtg     4380

taattggtca tccaatagat tcagaatcta aagaagatga accttgtagt gaagaaacag     4440

atccagtgca tgatctaatg gctgaaattt tacctgaatt ccctgacata attgaaatag     4500

acctatacca cagtgaagaa aatgaagaag aagaagaaga gtgtgcaaat gctactgatg     4560

tgacaaccac cccatctgtg cagtacataa atgggaagca tctcgttacc actgtgccca     4620

aggacccaga agctgcagaa gctaggcgtg gccagtttga aagtgttgca ccttctcaga     4680

atttctcgga cagctctgaa agtgatactc atccatttgt aatagccaaa acggaattgt     4740

ctactgctgt gcaacctaat gaatctacag aaacaactga gtctcttgaa gttacatgga     4800

agcctgagac ttaccctgaa acatcagaac atttttcagg tggtgagcct gatgttttcc     4860

ccacagtccc attccatgag gaatttgaaa gtggaacagc caaaaaaggg gcagaatcag     4920

tcacagagag agatactgaa gttggtcatc aggcacatga acatactgaa cctgtatctc     4980

tgtttcctga agagtcttca ggagagattg ccattgacca agaatctcag aaaatagcct     5040

ttgcaagggc tacagaagta acatttggtg aagaggtaga aaaaagtact tctgtcacat     5100

acactcccac tatagttcca agttctgcat cagcatatgt ttcagaggaa gaagcagtta     5160

ccctaatagg aaatccttgg ccagatgacc tgttgtctac caaagaaagc tgggtagaag     5220

caactcctag acaagttgta gagctctcag ggagttcttc gattccaatt acagaaggct     5280

ctggagaagc agaagaagat gaagatacaa tgttcaccat ggtaactgat ttatcacaga     5340

gaaatactac tgatacactc attactttag acactagcag gataatcaca gaaagctttt     5400

ttgaggttcc tgcaaccacc atttatccag tttctgaaca accttctgca aaagtggtgc     5460

ctaccaagtt tgtaagtgaa acagacactt ctgagtggat ttccagtacc actgttgagg     5520

aaaagaaaag gaaggaggag gagggaacta caggtacggc ttctacattt gaggtatatt     5580

catctacaca gagatcggat caattaattt taccctttga attagaaagt ccaaatgtag     5640

ctacatctag tgattcaggt accaggaaaa gttttatgtc cttgacaaca ccaacacagt     5700

ctgaaaggga aatgacagat tctactcctg tctttacaga aacaaataca ttagaaaatt     5760

tgggggcaca gaccactgag cacagcagta tccatcaacc tggggttcag gaagggctga     5820

ccactctccc acgtagtcct gcctctgtct ttatggagca gggctctgga gaagctgctg     5880

ccgacccaga aaccaccact gtttcttcat tttcattaaa cgtagagtat gcaattcaag     5940

ccgaaaagga agtagctggc actttgtctc cgcatgtgga aactacattc tccactgagc     6000

caacaggact ggttttgagt acagtaatgg acagagtagt tgctgaaaat ataacccaaa     6060

catccaggga aatagtgatt tcagagcgat taggagaacc aaattatggg gcagaaataa     6120

ggggcttttc cacaggtttt cctttggagg aagatttcag tggtgacttt agagaatact     6180

caacagtgtc tcatcccata gcaaaagaag aaacggtaat gatggaaggc tctggagatg     6240

cagcatttag ggacacccag acttcaccat ctacagtacc tacttcagtt cacatcagtc     6300

acatatctga ctcagaagga cccagtagca ccatggtcag cacttcagcc ttcccctggg     6360

aagagtttac atcctcagct gagggctcag gtgagcaact ggtcacagtc agcagctctg     6420

ttgttccagt gcttcccagt gctgtgcaaa agttttctgg tacagcttcc tccattatcg     6480

acgaaggatt gggagaagtg ggtactgtca atgaaattga tagaagatcc accattttac     6540

caacagcaga agtggaaggt acgaaagctc cagtagagaa ggaggaagta aaggtcagtg     6600

gcacagtttc aacaaacttt ccccaaacta tagagccagc caaattatgg tctaggcaag     6660

aagtcaaccc tgtaagacaa gaaattgaaa gtgaaacaac atcagaggaa caaattcaag     6720

aagaaaagtc atttgaatcc cctcaaaact ctcctgcaac agaacaaaca atctttgatt     6780

cacagacatt tactgaaact gaactcaaaa ccacagatta ttctgtacta acaacaaaga     6840

aaacttacag tgatgataaa gaaatgaagg aggaagacac ttctttagtt aacatgtcta     6900

ctccagatcc agatgcaaat ggcttggaat cttacacaac tctccctgaa gctactgaaa     6960

agtcacattt tttcttagct actgcattag taactgaatc tataccagct gaacatgtag     7020

tcacagattc accaatcaaa aaggaagaaa gtacaaaaca ttttccgaaa ggcatgagac     7080

caacaattca agagtcagat actgagctct tattctctgg actgggatca ggagaagaag     7140

ttttacctac tctaccaaca gagtcagtga attttactga agtggaacaa atcaataaca     7200

cattatatcc ccacacttct caagtggaaa gtacctcaag tgacaaaatt gaagacttta     7260

acagaatgga aaatgtggca aaagaagttg gaccactcgt atctcaaaca gacatctttg     7320

aaggtagtgg gtcagtaacc agcacaacat taatagaaat tttaagtgac actggagcag     7380

aaggacccac ggtggcacct ctccctttct ccacggacat cggacatcct caaaatcaga     7440

ctgtcaggtg ggcagaagaa atccagacta gtagaccaca aaccataact gaacaagact     7500

ctaacaagaa ttcttcaaca gcagaaatta acgaaacaac aacctcatct actgattttc     7560

tggctagagc ttatggtttt gaaatggcca aagaatttgt tacatcagca ccaaaaccat     7620

ctgacttgta ttatgaacct tctggagaag gatctggaga agtggatatt gttgattcat     7680

ttcacacttc tgcaactact caggcaacca gacaagaaag cagcaccaca tttgtttctg     7740

atgggtccct ggaaaaacat cctgaggtgc caagcgctaa agctgttact gctgatggat     7800

tcccaacagt ttcagtgatg ctgcctcttc attcagagca gaacaaaagc tcccctgatc     7860

caactagcac actgtcaaat acagtgtcat atgagaggtc cacagacggt agtttccaag     7920

accgtttcag ggaattcgag gattccacct taaaacctaa cagaaaaaaa cccactgaaa     7980

atattatcat agacctggac aaagaggaca aggatttaat attgacaatt acagagagta     8040

ccatccttga aattctacct gagctgacat cggataaaaa tactatcata gatattgatc     8100

atactaaacc tgtgtatgaa gacattcttg gaatgcaaac agatatagat acagaggtac     8160

catcagaacc acatgacagt aatgatgaaa gtaatgatga cagcactcaa gttcaagaga     8220

tctatgaggc agctgtcaac ctttctttaa ctgaggaaac atttgagggc tctgctgatg     8280

ttctggctag ctacactcag gcaacacatg atgaatcaat gacttatgaa gatagaagcc     8340

aactagatca catgggcttt cacttcacaa ctgggatccc tgctcctagc acagaaacag     8400

aattagacgt tttacttccc acggcaacat ccctgccaat tcctcgtaag tctgccacag     8460

ttattccaga gattgaagga ataaaagctg aagcaaaagc cctggatgac atgtttgaat     8520

caagcacttt gtctgatggt caagctattg cagaccaaag tgaaataata ccaacattgg     8580

gccaatttga aaggactcag gaggagtatg aagacaaaaa acatgctggt ccttcttttc     8640

agccagaatt ctcttcagga gctgaggagg cattagtaga ccatactccc tatctaagta     8700

ttgctactac ccaccttatg gatcagagtg taacagaggt gcctgatgtg atggaaggat     8760

ccaatccccc atattacact gatacaacat tagcagtttc aacatttgcg aagttgtctt     8820

ctcagacacc atcatctccc ctcactatct actcaggcag tgaagcctct ggacacacag     8880

agatccccca gcccagtgct ctgccaggaa tagacgtcgg ctcatctgta atgtccccac     8940

aggattcttt taaggaaatt catgtaaata ttgaagcgac tttcaaacca tcaagtgagg     9000

aataccttca cataactgag cctccctctt tatctcctga cacaaaatta gaaccttcag     9060

aagatgatgg taaacctgag ttattagaag aaatggaagc ttctcccaca gaacttattg     9120

ctgtggaagg aactgagatt ctccaagatt tccaaaacaa aaccgatggt caagtttctg     9180

gagaagcaat caagatgttt cccaccatta aaacacctga ggctggaact gttattacaa     9240

ctgccgatga aattgaatta gaaggtgcta cacagtggcc acactctact tctgcttctg     9300

ccacctatgg ggtcgaggca ggtgtggtgc cttggctaag tccacagact tctgagaggc     9360

ccacgctttc ttcttctcca gaaataaacc ctgaaactca agcagcttta atcagagggc     9420

aggattccac gatagcagca tcagaacagc aagtggcagc gagaattctt gattccaatg     9480

atcaggcaac agtaaaccct gtggaattta atactgaggt tgcaacacca ccattttccc     9540

ttctggagac ttctaatgaa acagatttcc tgattggcat taatgaagag tcagtggaag     9600

gcacggcaat ctatttacca ggacctgatc gctgcaaaat gaacccgtgc cttaacggag     9660

gcacctgtta tcctactgaa acttcctacg tatgcacctg tgtgccagga tacagcggag     9720

accagtgtga acttgatttt gatgaatgtc actctaatcc ctgtcgtaat ggagccactt     9780

gtgttgatgg ttttaacaca ttcaggtgcc tctgccttcc aagttatgtt ggtgcacttt     9840

gtgagcaaga taccgagaca tgtgactatg gctggcacaa attccaaggg cagtgctaca     9900

aatactttgc ccatcgacgc acatgggatg cagctgaacg ggaatgccgt ctgcagggtg     9960

cccatctcac aagcatcctg tctcacgaag aacaaatgtt tgttaatcgt gtgggccatg    10020

attatcagtg gataggcctc aatgacaaga tgtttgagca tgacttccgt tggactgatg    10080

gcagcacact gcaatacgag aattggagac ccaaccagcc agacagcttc ttttctgctg    10140

gagaagactg tgttgtaatc atttggcatg agaatggcca gtggaatgat gttccctgca    10200

attaccatct cacctatacg tgcaagaaag gaacagtcgc ttgcggccag ccccctgttg    10260

tagaaaatgc caagaccttt ggaaagatga aacctcgtta tgaaatcaac tccctgatta    10320

gataccactg caaagatggt ttcattcaac gtcaccttcc aactatccgg tgcttaggaa    10380

atggaagatg ggctatacct aaaattacct gcatgaaccc atctgcatac caaaggactt    10440

attctatgaa atactttaaa aattcctcat cagcaaagga caattcaata aatacatcca    10500

aacatgatca tcgttggagc cggaggtggc aggagtcgag gcgctgatcc ctaaaatggc    10560

gaacatgtgt tttcatcatt tcagccaaag tcctaacttc ctgtgccttt cctatcacct    10620

cgagaagtaa ttatcagttg gtttggattt ttggaccacc gttcagtcat tttgggttgc    10680

cgtgctccca aaacatttta aatgaaagta ttggcattca aaaagacagc agacaaaatg    10740

aaagaaaatg agagcagaaa gtaagcattt ccagcctatc taatttcttt agttttctat    10800

ttgcctccag tgcagtccat ttcctaatgt ataccagcct actgtactat ttaaaatgct    10860

caatttcagc accgatggcc atgtaaataa gatgatttaa tgttgatttt aatcctgtat    10920

ataaaataaa aagtcacaat gagtttgggc atatttaatg atgattatgg agccttagag    10980

gtctttaatc attggttcgg ctgcttttat gtagtttagg ctggaaatgg tttcacttgc    11040

tctttgactg tcagcaagac tgaagatggc ttttcctgga cagctagaaa acacaaaatc    11100

ttgtaggtca ttgcacctat ctcagccata ggtgcagttt gcttctacat gatgctaaag    11160

gctgcgaatg ggatcctgat ggaactaagg actccaatgt cgaactcttc tttgctgcat    11220

tcctttttct tcacttacaa gaaaggcctg aatggaggac ttttctgtaa ccaggaacat    11280

tttttagggg tcaaagtgct aataattaac tcaaccaggt ctacttttta atggctttca    11340

taacactaac tcataaggtt accgatcaat gcatttcata cggatataga cctagggctc    11400

tggagggtgg gggattgtta aaacacatgc aaaaaaaaaa aaaaaaaaaa aaaaagaaat    11460

tttgtatata taaccatttt aatcttttat aaagttttga atgttcatgt atgaatgctg    11520

cagctgtgaa gcatacataa ataaatgaag taagccatac tgatttaatt tattggatgt    11580

tattttccct aagacctgaa aatgaacata gtatgctagt tatttttcag tgttagcctt    11640

ttactttcct cacacaattt ggaatcatat aatataggta ctttgtccct gattaaataa    11700

tgtgacggat agaatgcatc aagtgtttat tatgaaaaga gtggaaaagt atatagcttt    11760

tagcaaaagg tgtttgccca ttctaagaaa tgagcgaata tatagaaata gtgtgggcat    11820

ttcttcctgt taggtggagt gtatgtgttg acatttctcc ccatctcttc ccactctgtt    11880

ttctccccat tatttgaata aagtgactgc tgaagatgac tttgaatcct tatccactta    11940

atttaatgtt taaagaaaaa cctgtaatgg aaagtaagac tccttcccta atttcagttt    12000

agagcaactt gaagaagagt agacaaaaaa taaaatgcac atagaaaaag agaaaaaggg    12060

cacaaaggga ttggcccaat attgattctt tttttataaa acctcctttg gcttagaagg    12120

aatgactcta gctacaataa tacacagtat gtttaagcag gttcccttgg ttgttgcatt    12180

aaatgtaatc cacctttagg tattttagag cacagaacaa cactgtgttg atctagtagg    12240

tttctatttt tcctttctct ttacaatgca cataatactt tcctgtattt atatcataac    12300

gtgtatagtg taaaatgtga atgacttttt ttgtgaatga aaatctaaaa tctttgtaac    12360

tttttatatc tgcttttgtt tcaccaaaga aacctaaaat ccttctttta ctacac        12416


<210>  126
<211>  655
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Arg Pro Asp Arg Cys 
            340                 345                 350         


Lys Met Asn Pro Cys Leu Asn Gly Gly Thr Cys Tyr Pro Thr Glu Thr 
        355                 360                 365             


Ser Tyr Val Cys Thr Cys Val Pro Gly Tyr Ser Gly Asp Gln Cys Glu 
    370                 375                 380                 


Leu Asp Phe Asp Glu Cys His Ser Asn Pro Cys Arg Asn Gly Ala Thr 
385                 390                 395                 400 


Cys Val Asp Gly Phe Asn Thr Phe Arg Cys Leu Cys Leu Pro Ser Tyr 
                405                 410                 415     


Val Gly Ala Leu Cys Glu Gln Asp Thr Glu Thr Cys Asp Tyr Gly Trp 
            420                 425                 430         


His Lys Phe Gln Gly Gln Cys Tyr Lys Tyr Phe Ala His Arg Arg Thr 
        435                 440                 445             


Trp Asp Ala Ala Glu Arg Glu Cys Arg Leu Gln Gly Ala His Leu Thr 
    450                 455                 460                 


Ser Ile Leu Ser His Glu Glu Gln Met Phe Val Asn Arg Val Gly His 
465                 470                 475                 480 


Asp Tyr Gln Trp Ile Gly Leu Asn Asp Lys Met Phe Glu His Asp Phe 
                485                 490                 495     


Arg Trp Thr Asp Gly Ser Thr Leu Gln Tyr Glu Asn Trp Arg Pro Asn 
            500                 505                 510         


Gln Pro Asp Ser Phe Phe Ser Ala Gly Glu Asp Cys Val Val Ile Ile 
        515                 520                 525             


Trp His Glu Asn Gly Gln Trp Asn Asp Val Pro Cys Asn Tyr His Leu 
    530                 535                 540                 


Thr Tyr Thr Cys Lys Lys Gly Thr Val Ala Cys Gly Gln Pro Pro Val 
545                 550                 555                 560 


Val Glu Asn Ala Lys Thr Phe Gly Lys Met Lys Pro Arg Tyr Glu Ile 
                565                 570                 575     


Asn Ser Leu Ile Arg Tyr His Cys Lys Asp Gly Phe Ile Gln Arg His 
            580                 585                 590         


Leu Pro Thr Ile Arg Cys Leu Gly Asn Gly Arg Trp Ala Ile Pro Lys 
        595                 600                 605             


Ile Thr Cys Met Asn Pro Ser Ala Tyr Gln Arg Thr Tyr Ser Met Lys 
    610                 615                 620                 


Tyr Phe Lys Asn Ser Ser Ser Ala Lys Asp Asn Ser Ile Asn Thr Ser 
625                 630                 635                 640 


Lys His Asp His Arg Trp Ser Arg Arg Trp Gln Glu Ser Arg Arg 
                645                 650                 655 


<210>  127
<211>  2409
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Arg Arg Met Ser Asp 
            340                 345                 350         


Leu Ser Val Ile Gly His Pro Ile Asp Ser Glu Ser Lys Glu Asp Glu 
        355                 360                 365             


Pro Cys Ser Glu Glu Thr Asp Pro Val His Asp Leu Met Ala Glu Ile 
    370                 375                 380                 


Leu Pro Glu Phe Pro Asp Ile Ile Glu Ile Asp Leu Tyr His Ser Glu 
385                 390                 395                 400 


Glu Asn Glu Glu Glu Glu Glu Glu Cys Ala Asn Ala Thr Asp Val Thr 
                405                 410                 415     


Thr Thr Pro Ser Val Gln Tyr Ile Asn Gly Lys His Leu Val Thr Thr 
            420                 425                 430         


Val Pro Lys Asp Pro Glu Ala Ala Glu Ala Arg Arg Gly Gln Phe Glu 
        435                 440                 445             


Ser Val Ala Pro Ser Gln Asn Phe Ser Asp Ser Ser Glu Ser Asp Thr 
    450                 455                 460                 


His Pro Phe Val Ile Ala Lys Thr Glu Leu Ser Thr Ala Val Gln Pro 
465                 470                 475                 480 


Asn Glu Ser Thr Glu Thr Thr Glu Ser Leu Glu Val Thr Trp Lys Pro 
                485                 490                 495     


Glu Thr Tyr Pro Glu Thr Ser Glu His Phe Ser Gly Gly Glu Pro Asp 
            500                 505                 510         


Val Phe Pro Thr Val Pro Phe His Glu Glu Phe Glu Ser Gly Thr Ala 
        515                 520                 525             


Lys Lys Gly Ala Glu Ser Val Thr Glu Arg Asp Thr Glu Val Gly His 
    530                 535                 540                 


Gln Ala His Glu His Thr Glu Pro Val Ser Leu Phe Pro Glu Glu Ser 
545                 550                 555                 560 


Ser Gly Glu Ile Ala Ile Asp Gln Glu Ser Gln Lys Ile Ala Phe Ala 
                565                 570                 575     


Arg Ala Thr Glu Val Thr Phe Gly Glu Glu Val Glu Lys Ser Thr Ser 
            580                 585                 590         


Val Thr Tyr Thr Pro Thr Ile Val Pro Ser Ser Ala Ser Ala Tyr Val 
        595                 600                 605             


Ser Glu Glu Glu Ala Val Thr Leu Ile Gly Asn Pro Trp Pro Asp Asp 
    610                 615                 620                 


Leu Leu Ser Thr Lys Glu Ser Trp Val Glu Ala Thr Pro Arg Gln Val 
625                 630                 635                 640 


Val Glu Leu Ser Gly Ser Ser Ser Ile Pro Ile Thr Glu Gly Ser Gly 
                645                 650                 655     


Glu Ala Glu Glu Asp Glu Asp Thr Met Phe Thr Met Val Thr Asp Leu 
            660                 665                 670         


Ser Gln Arg Asn Thr Thr Asp Thr Leu Ile Thr Leu Asp Thr Ser Arg 
        675                 680                 685             


Ile Ile Thr Glu Ser Phe Phe Glu Val Pro Ala Thr Thr Ile Tyr Pro 
    690                 695                 700                 


Val Ser Glu Gln Pro Ser Ala Lys Val Val Pro Thr Lys Phe Val Ser 
705                 710                 715                 720 


Glu Thr Asp Thr Ser Glu Trp Ile Ser Ser Thr Thr Val Glu Glu Lys 
                725                 730                 735     


Lys Arg Lys Glu Glu Glu Gly Thr Thr Gly Thr Ala Ser Thr Phe Glu 
            740                 745                 750         


Val Tyr Ser Ser Thr Gln Arg Ser Asp Gln Leu Ile Leu Pro Phe Glu 
        755                 760                 765             


Leu Glu Ser Pro Asn Val Ala Thr Ser Ser Asp Ser Gly Thr Arg Lys 
    770                 775                 780                 


Ser Phe Met Ser Leu Thr Thr Pro Thr Gln Ser Glu Arg Glu Met Thr 
785                 790                 795                 800 


Asp Ser Thr Pro Val Phe Thr Glu Thr Asn Thr Leu Glu Asn Leu Gly 
                805                 810                 815     


Ala Gln Thr Thr Glu His Ser Ser Ile His Gln Pro Gly Val Gln Glu 
            820                 825                 830         


Gly Leu Thr Thr Leu Pro Arg Ser Pro Ala Ser Val Phe Met Glu Gln 
        835                 840                 845             


Gly Ser Gly Glu Ala Ala Ala Asp Pro Glu Thr Thr Thr Val Ser Ser 
    850                 855                 860                 


Phe Ser Leu Asn Val Glu Tyr Ala Ile Gln Ala Glu Lys Glu Val Ala 
865                 870                 875                 880 


Gly Thr Leu Ser Pro His Val Glu Thr Thr Phe Ser Thr Glu Pro Thr 
                885                 890                 895     


Gly Leu Val Leu Ser Thr Val Met Asp Arg Val Val Ala Glu Asn Ile 
            900                 905                 910         


Thr Gln Thr Ser Arg Glu Ile Val Ile Ser Glu Arg Leu Gly Glu Pro 
        915                 920                 925             


Asn Tyr Gly Ala Glu Ile Arg Gly Phe Ser Thr Gly Phe Pro Leu Glu 
    930                 935                 940                 


Glu Asp Phe Ser Gly Asp Phe Arg Glu Tyr Ser Thr Val Ser His Pro 
945                 950                 955                 960 


Ile Ala Lys Glu Glu Thr Val Met Met Glu Gly Ser Gly Asp Ala Ala 
                965                 970                 975     


Phe Arg Asp Thr Gln Thr Ser Pro Ser Thr Val Pro Thr Ser Val His 
            980                 985                 990         


Ile Ser His Ile Ser Asp Ser Glu  Gly Pro Ser Ser Thr  Met Val Ser 
        995                 1000                 1005             


Thr Ser  Ala Phe Pro Trp Glu  Glu Phe Thr Ser Ser  Ala Glu Gly 
    1010                 1015                 1020             


Ser Gly  Glu Gln Leu Val Thr  Val Ser Ser Ser Val  Val Pro Val 
    1025                 1030                 1035             


Leu Pro  Ser Ala Val Gln Lys  Phe Ser Gly Thr Ala  Ser Ser Ile 
    1040                 1045                 1050             


Ile Asp  Glu Gly Leu Gly Glu  Val Gly Thr Val Asn  Glu Ile Asp 
    1055                 1060                 1065             


Arg Arg  Ser Thr Ile Leu Pro  Thr Ala Glu Val Glu  Gly Thr Lys 
    1070                 1075                 1080             


Ala Pro  Val Glu Lys Glu Glu  Val Lys Val Ser Gly  Thr Val Ser 
    1085                 1090                 1095             


Thr Asn  Phe Pro Gln Thr Ile  Glu Pro Ala Lys Leu  Trp Ser Arg 
    1100                 1105                 1110             


Gln Glu  Val Asn Pro Val Arg  Gln Glu Ile Glu Ser  Glu Thr Thr 
    1115                 1120                 1125             


Ser Glu  Glu Gln Ile Gln Glu  Glu Lys Ser Phe Glu  Ser Pro Gln 
    1130                 1135                 1140             


Asn Ser  Pro Ala Thr Glu Gln  Thr Ile Phe Asp Ser  Gln Thr Phe 
    1145                 1150                 1155             


Thr Glu  Thr Glu Leu Lys Thr  Thr Asp Tyr Ser Val  Leu Thr Thr 
    1160                 1165                 1170             


Lys Lys  Thr Tyr Ser Asp Asp  Lys Glu Met Lys Glu  Glu Asp Thr 
    1175                 1180                 1185             


Ser Leu  Val Asn Met Ser Thr  Pro Asp Pro Asp Ala  Asn Gly Leu 
    1190                 1195                 1200             


Glu Ser  Tyr Thr Thr Leu Pro  Glu Ala Thr Glu Lys  Ser His Phe 
    1205                 1210                 1215             


Phe Leu  Ala Thr Ala Leu Val  Thr Glu Ser Ile Pro  Ala Glu His 
    1220                 1225                 1230             


Val Val  Thr Asp Ser Pro Ile  Lys Lys Glu Glu Ser  Thr Lys His 
    1235                 1240                 1245             


Phe Pro  Lys Gly Met Arg Pro  Thr Ile Gln Glu Ser  Asp Thr Glu 
    1250                 1255                 1260             


Leu Leu  Phe Ser Gly Leu Gly  Ser Gly Glu Glu Val  Leu Pro Thr 
    1265                 1270                 1275             


Leu Pro  Thr Glu Ser Val Asn  Phe Thr Glu Val Glu  Gln Ile Asn 
    1280                 1285                 1290             


Asn Thr  Leu Tyr Pro His Thr  Ser Gln Val Glu Ser  Thr Ser Ser 
    1295                 1300                 1305             


Asp Lys  Ile Glu Asp Phe Asn  Arg Met Glu Asn Val  Ala Lys Glu 
    1310                 1315                 1320             


Val Gly  Pro Leu Val Ser Gln  Thr Asp Ile Phe Glu  Gly Ser Gly 
    1325                 1330                 1335             


Ser Val  Thr Ser Thr Thr Leu  Ile Glu Ile Leu Ser  Asp Thr Gly 
    1340                 1345                 1350             


Ala Glu  Gly Pro Thr Val Ala  Pro Leu Pro Phe Ser  Thr Asp Ile 
    1355                 1360                 1365             


Gly His  Pro Gln Asn Gln Thr  Val Arg Trp Ala Glu  Glu Ile Gln 
    1370                 1375                 1380             


Thr Ser  Arg Pro Gln Thr Ile  Thr Glu Gln Asp Ser  Asn Lys Asn 
    1385                 1390                 1395             


Ser Ser  Thr Ala Glu Ile Asn  Glu Thr Thr Thr Ser  Ser Thr Asp 
    1400                 1405                 1410             


Phe Leu  Ala Arg Ala Tyr Gly  Phe Glu Met Ala Lys  Glu Phe Val 
    1415                 1420                 1425             


Thr Ser  Ala Pro Lys Pro Ser  Asp Leu Tyr Tyr Glu  Pro Ser Gly 
    1430                 1435                 1440             


Glu Gly  Ser Gly Glu Val Asp  Ile Val Asp Ser Phe  His Thr Ser 
    1445                 1450                 1455             


Ala Thr  Thr Gln Ala Thr Arg  Gln Glu Ser Ser Thr  Thr Phe Val 
    1460                 1465                 1470             


Ser Asp  Gly Ser Leu Glu Lys  His Pro Glu Val Pro  Ser Ala Lys 
    1475                 1480                 1485             


Ala Val  Thr Ala Asp Gly Phe  Pro Thr Val Ser Val  Met Leu Pro 
    1490                 1495                 1500             


Leu His  Ser Glu Gln Asn Lys  Ser Ser Pro Asp Pro  Thr Ser Thr 
    1505                 1510                 1515             


Leu Ser  Asn Thr Val Ser Tyr  Glu Arg Ser Thr Asp  Gly Ser Phe 
    1520                 1525                 1530             


Gln Asp  Arg Phe Arg Glu Phe  Glu Asp Ser Thr Leu  Lys Pro Asn 
    1535                 1540                 1545             


Arg Lys  Lys Pro Thr Glu Asn  Ile Ile Ile Asp Leu  Asp Lys Glu 
    1550                 1555                 1560             


Asp Lys  Asp Leu Ile Leu Thr  Ile Thr Glu Ser Thr  Ile Leu Glu 
    1565                 1570                 1575             


Ile Leu  Pro Glu Leu Thr Ser  Asp Lys Asn Thr Ile  Ile Asp Ile 
    1580                 1585                 1590             


Asp His  Thr Lys Pro Val Tyr  Glu Asp Ile Leu Gly  Met Gln Thr 
    1595                 1600                 1605             


Asp Ile  Asp Thr Glu Val Pro  Ser Glu Pro His Asp  Ser Asn Asp 
    1610                 1615                 1620             


Glu Ser  Asn Asp Asp Ser Thr  Gln Val Gln Glu Ile  Tyr Glu Ala 
    1625                 1630                 1635             


Ala Val  Asn Leu Ser Leu Thr  Glu Glu Thr Phe Glu  Gly Ser Ala 
    1640                 1645                 1650             


Asp Val  Leu Ala Ser Tyr Thr  Gln Ala Thr His Asp  Glu Ser Met 
    1655                 1660                 1665             


Thr Tyr  Glu Asp Arg Ser Gln  Leu Asp His Met Gly  Phe His Phe 
    1670                 1675                 1680             


Thr Thr  Gly Ile Pro Ala Pro  Ser Thr Glu Thr Glu  Leu Asp Val 
    1685                 1690                 1695             


Leu Leu  Pro Thr Ala Thr Ser  Leu Pro Ile Pro Arg  Lys Ser Ala 
    1700                 1705                 1710             


Thr Val  Ile Pro Glu Ile Glu  Gly Ile Lys Ala Glu  Ala Lys Ala 
    1715                 1720                 1725             


Leu Asp  Asp Met Phe Glu Ser  Ser Thr Leu Ser Asp  Gly Gln Ala 
    1730                 1735                 1740             


Ile Ala  Asp Gln Ser Glu Ile  Ile Pro Thr Leu Gly  Gln Phe Glu 
    1745                 1750                 1755             


Arg Thr  Gln Glu Glu Tyr Glu  Asp Lys Lys His Ala  Gly Pro Ser 
    1760                 1765                 1770             


Phe Gln  Pro Glu Phe Ser Ser  Gly Ala Glu Glu Ala  Leu Val Asp 
    1775                 1780                 1785             


His Thr  Pro Tyr Leu Ser Ile  Ala Thr Thr His Leu  Met Asp Gln 
    1790                 1795                 1800             


Ser Val  Thr Glu Val Pro Asp  Val Met Glu Gly Ser  Asn Pro Pro 
    1805                 1810                 1815             


Tyr Tyr  Thr Asp Thr Thr Leu  Ala Val Ser Thr Phe  Ala Lys Leu 
    1820                 1825                 1830             


Ser Ser  Gln Thr Pro Ser Ser  Pro Leu Thr Ile Tyr  Ser Gly Ser 
    1835                 1840                 1845             


Glu Ala  Ser Gly His Thr Glu  Ile Pro Gln Pro Ser  Ala Leu Pro 
    1850                 1855                 1860             


Gly Ile  Asp Val Gly Ser Ser  Val Met Ser Pro Gln  Asp Ser Phe 
    1865                 1870                 1875             


Lys Glu  Ile His Val Asn Ile  Glu Ala Thr Phe Lys  Pro Ser Ser 
    1880                 1885                 1890             


Glu Glu  Tyr Leu His Ile Thr  Glu Pro Pro Ser Leu  Ser Pro Asp 
    1895                 1900                 1905             


Thr Lys  Leu Glu Pro Ser Glu  Asp Asp Gly Lys Pro  Glu Leu Leu 
    1910                 1915                 1920             


Glu Glu  Met Glu Ala Ser Pro  Thr Glu Leu Ile Ala  Val Glu Gly 
    1925                 1930                 1935             


Thr Glu  Ile Leu Gln Asp Phe  Gln Asn Lys Thr Asp  Gly Gln Val 
    1940                 1945                 1950             


Ser Gly  Glu Ala Ile Lys Met  Phe Pro Thr Ile Lys  Thr Pro Glu 
    1955                 1960                 1965             


Ala Gly  Thr Val Ile Thr Thr  Ala Asp Glu Ile Glu  Leu Glu Gly 
    1970                 1975                 1980             


Ala Thr  Gln Trp Pro His Ser  Thr Ser Ala Ser Ala  Thr Tyr Gly 
    1985                 1990                 1995             


Val Glu  Ala Gly Val Val Pro  Trp Leu Ser Pro Gln  Thr Ser Glu 
    2000                 2005                 2010             


Arg Pro  Thr Leu Ser Ser Ser  Pro Glu Ile Asn Pro  Glu Thr Gln 
    2015                 2020                 2025             


Ala Ala  Leu Ile Arg Gly Gln  Asp Ser Thr Ile Ala  Ala Ser Glu 
    2030                 2035                 2040             


Gln Gln  Val Ala Ala Arg Ile  Leu Asp Ser Asn Asp  Gln Ala Thr 
    2045                 2050                 2055             


Val Asn  Pro Val Glu Phe Asn  Thr Glu Val Ala Thr  Pro Pro Phe 
    2060                 2065                 2070             


Ser Leu  Leu Glu Thr Ser Asn  Glu Thr Asp Phe Leu  Ile Gly Ile 
    2075                 2080                 2085             


Asn Glu  Glu Ser Val Glu Gly  Thr Ala Ile Tyr Leu  Pro Gly Pro 
    2090                 2095                 2100             


Asp Arg  Cys Lys Met Asn Pro  Cys Leu Asn Gly Gly  Thr Cys Tyr 
    2105                 2110                 2115             


Pro Thr  Glu Thr Ser Tyr Val  Cys Thr Cys Val Pro  Gly Tyr Ser 
    2120                 2125                 2130             


Gly Asp  Gln Cys Glu Leu Asp  Phe Asp Glu Cys His  Ser Asn Pro 
    2135                 2140                 2145             


Cys Arg  Asn Gly Ala Thr Cys  Val Asp Gly Phe Asn  Thr Phe Arg 
    2150                 2155                 2160             


Cys Leu  Cys Leu Pro Ser Tyr  Val Gly Ala Leu Cys  Glu Gln Asp 
    2165                 2170                 2175             


Thr Glu  Thr Cys Asp Tyr Gly  Trp His Lys Phe Gln  Gly Gln Cys 
    2180                 2185                 2190             


Tyr Lys  Tyr Phe Ala His Arg  Arg Thr Trp Asp Ala  Ala Glu Arg 
    2195                 2200                 2205             


Glu Cys  Arg Leu Gln Gly Ala  His Leu Thr Ser Ile  Leu Ser His 
    2210                 2215                 2220             


Glu Glu  Gln Met Phe Val Asn  Arg Val Gly His Asp  Tyr Gln Trp 
    2225                 2230                 2235             


Ile Gly  Leu Asn Asp Lys Met  Phe Glu His Asp Phe  Arg Trp Thr 
    2240                 2245                 2250             


Asp Gly  Ser Thr Leu Gln Tyr  Glu Asn Trp Arg Pro  Asn Gln Pro 
    2255                 2260                 2265             


Asp Ser  Phe Phe Ser Ala Gly  Glu Asp Cys Val Val  Ile Ile Trp 
    2270                 2275                 2280             


His Glu  Asn Gly Gln Trp Asn  Asp Val Pro Cys Asn  Tyr His Leu 
    2285                 2290                 2295             


Thr Tyr  Thr Cys Lys Lys Gly  Thr Val Ala Cys Gly  Gln Pro Pro 
    2300                 2305                 2310             


Val Val  Glu Asn Ala Lys Thr  Phe Gly Lys Met Lys  Pro Arg Tyr 
    2315                 2320                 2325             


Glu Ile  Asn Ser Leu Ile Arg  Tyr His Cys Lys Asp  Gly Phe Ile 
    2330                 2335                 2340             


Gln Arg  His Leu Pro Thr Ile  Arg Cys Leu Gly Asn  Gly Arg Trp 
    2345                 2350                 2355             


Ala Ile  Pro Lys Ile Thr Cys  Met Asn Pro Ser Ala  Tyr Gln Arg 
    2360                 2365                 2370             


Thr Tyr  Ser Met Lys Tyr Phe  Lys Asn Ser Ser Ser  Ala Lys Asp 
    2375                 2380                 2385             


Asn Ser  Ile Asn Thr Ser Lys  His Asp His Arg Trp  Ser Arg Arg 
    2390                 2395                 2400             


Trp Gln  Glu Ser Arg Arg 
    2405                 


<210>  128
<211>  1642
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr 
            340                 345                 350         


Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser 
        355                 360                 365             


Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu 
    370                 375                 380                 


Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn 
385                 390                 395                 400 


Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr 
                405                 410                 415     


Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys 
            420                 425                 430         


Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly 
        435                 440                 445             


Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr 
    450                 455                 460                 


Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp 
465                 470                 475                 480 


Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly 
                485                 490                 495     


Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu 
            500                 505                 510         


Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu 
        515                 520                 525             


Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr 
    530                 535                 540                 


Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg 
545                 550                 555                 560 


Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile 
                565                 570                 575     


Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr 
            580                 585                 590         


His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro 
        595                 600                 605             


Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu 
    610                 615                 620                 


Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu 
625                 630                 635                 640 


Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe 
                645                 650                 655     


Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile 
            660                 665                 670         


Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu 
        675                 680                 685             


Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln 
    690                 695                 700                 


Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val 
705                 710                 715                 720 


Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val 
                725                 730                 735     


Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu 
            740                 745                 750         


Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu 
        755                 760                 765             


Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr 
    770                 775                 780                 


Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val 
785                 790                 795                 800 


Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu 
                805                 810                 815     


Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr 
            820                 825                 830         


Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu 
        835                 840                 845             


Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln 
    850                 855                 860                 


Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr 
865                 870                 875                 880 


Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr 
                885                 890                 895     


Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr 
            900                 905                 910         


Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val 
        915                 920                 925             


Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala 
    930                 935                 940                 


His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr 
945                 950                 955                 960 


Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser 
                965                 970                 975     


Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser 
            980                 985                 990         


Glu Asp Glu Val Leu Gly Glu Pro  Ser Gln Asp Ile Leu  Val Ile Asp 
        995                 1000                 1005             


Gln Thr  Arg Leu Glu Ala Thr  Ile Ser Pro Glu Thr  Met Arg Thr 
    1010                 1015                 1020             


Thr Lys  Ile Thr Glu Gly Thr  Thr Gln Glu Glu Phe  Pro Trp Lys 
    1025                 1030                 1035             


Glu Gln  Thr Ala Glu Lys Pro  Val Pro Ala Leu Ser  Ser Thr Ala 
    1040                 1045                 1050             


Trp Thr  Pro Lys Glu Ala Val  Thr Pro Leu Asp Glu  Gln Glu Gly 
    1055                 1060                 1065             


Asp Gly  Ser Ala Tyr Thr Val  Ser Glu Asp Glu Leu  Leu Thr Gly 
    1070                 1075                 1080             


Ser Glu  Arg Val Pro Val Leu  Glu Thr Thr Pro Val  Gly Lys Ile 
    1085                 1090                 1095             


Asp His  Ser Val Ser Tyr Pro  Pro Gly Ala Val Thr  Glu His Lys 
    1100                 1105                 1110             


Val Lys  Thr Asp Glu Val Val  Thr Leu Thr Pro Arg  Ile Gly Pro 
    1115                 1120                 1125             


Lys Val  Ser Leu Ser Pro Gly  Pro Glu Gln Lys Tyr  Glu Thr Glu 
    1130                 1135                 1140             


Gly Ser  Ser Thr Thr Gly Phe  Thr Ser Ser Leu Ser  Pro Phe Ser 
    1145                 1150                 1155             


Thr His  Ile Thr Gln Leu Met  Glu Glu Thr Thr Thr  Glu Lys Thr 
    1160                 1165                 1170             


Ser Leu  Glu Asp Ile Asp Leu  Gly Ser Gly Leu Phe  Glu Lys Pro 
    1175                 1180                 1185             


Lys Ala  Thr Glu Leu Ile Glu  Phe Ser Thr Ile Lys  Val Thr Val 
    1190                 1195                 1200             


Pro Ser  Asp Ile Thr Thr Ala  Phe Ser Ser Val Asp  Arg Leu His 
    1205                 1210                 1215             


Thr Thr  Ser Ala Phe Lys Pro  Ser Ser Ala Ile Thr  Lys Lys Pro 
    1220                 1225                 1230             


Pro Leu  Ile Asp Arg Glu Pro  Gly Glu Glu Thr Thr  Ser Asp Met 
    1235                 1240                 1245             


Val Ile  Ile Gly Glu Ser Thr  Ser His Val Pro Pro  Thr Thr Leu 
    1250                 1255                 1260             


Glu Asp  Ile Val Ala Lys Glu  Thr Glu Thr Asp Ile  Asp Arg Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Thr Ser Ser Pro  Pro Ala Thr Gln Pro  Thr Arg Pro 
    1280                 1285                 1290             


Pro Thr  Val Glu Asp Lys Glu  Ala Phe Gly Pro Gln  Ala Leu Ser 
    1295                 1300                 1305             


Thr Pro  Gln Pro Pro Ala Ser  Thr Lys Phe His Pro  Asp Ile Asn 
    1310                 1315                 1320             


Val Tyr  Ile Ile Glu Val Arg  Glu Asn Lys Thr Gly  Pro Asp Arg 
    1325                 1330                 1335             


Cys Lys  Met Asn Pro Cys Leu  Asn Gly Gly Thr Cys  Tyr Pro Thr 
    1340                 1345                 1350             


Glu Thr  Ser Tyr Val Cys Thr  Cys Val Pro Gly Tyr  Ser Gly Asp 
    1355                 1360                 1365             


Gln Cys  Glu Leu Asp Phe Asp  Glu Cys His Ser Asn  Pro Cys Arg 
    1370                 1375                 1380             


Asn Gly  Ala Thr Cys Val Asp  Gly Phe Asn Thr Phe  Arg Cys Leu 
    1385                 1390                 1395             


Cys Leu  Pro Ser Tyr Val Gly  Ala Leu Cys Glu Gln  Asp Thr Glu 
    1400                 1405                 1410             


Thr Cys  Asp Tyr Gly Trp His  Lys Phe Gln Gly Gln  Cys Tyr Lys 
    1415                 1420                 1425             


Tyr Phe  Ala His Arg Arg Thr  Trp Asp Ala Ala Glu  Arg Glu Cys 
    1430                 1435                 1440             


Arg Leu  Gln Gly Ala His Leu  Thr Ser Ile Leu Ser  His Glu Glu 
    1445                 1450                 1455             


Gln Met  Phe Val Asn Arg Val  Gly His Asp Tyr Gln  Trp Ile Gly 
    1460                 1465                 1470             


Leu Asn  Asp Lys Met Phe Glu  His Asp Phe Arg Trp  Thr Asp Gly 
    1475                 1480                 1485             


Ser Thr  Leu Gln Tyr Glu Asn  Trp Arg Pro Asn Gln  Pro Asp Ser 
    1490                 1495                 1500             


Phe Phe  Ser Ala Gly Glu Asp  Cys Val Val Ile Ile  Trp His Glu 
    1505                 1510                 1515             


Asn Gly  Gln Trp Asn Asp Val  Pro Cys Asn Tyr His  Leu Thr Tyr 
    1520                 1525                 1530             


Thr Cys  Lys Lys Gly Thr Val  Ala Cys Gly Gln Pro  Pro Val Val 
    1535                 1540                 1545             


Glu Asn  Ala Lys Thr Phe Gly  Lys Met Lys Pro Arg  Tyr Glu Ile 
    1550                 1555                 1560             


Asn Ser  Leu Ile Arg Tyr His  Cys Lys Asp Gly Phe  Ile Gln Arg 
    1565                 1570                 1575             


His Leu  Pro Thr Ile Arg Cys  Leu Gly Asn Gly Arg  Trp Ala Ile 
    1580                 1585                 1590             


Pro Lys  Ile Thr Cys Met Asn  Pro Ser Ala Tyr Gln  Arg Thr Tyr 
    1595                 1600                 1605             


Ser Met  Lys Tyr Phe Lys Asn  Ser Ser Ser Ala Lys  Asp Asn Ser 
    1610                 1615                 1620             


Ile Asn  Thr Ser Lys His Asp  His Arg Trp Ser Arg  Arg Trp Gln 
    1625                 1630                 1635             


Glu Ser  Arg Arg 
    1640         


<210>  129
<211>  3396
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Phe Ile Asn Ile Lys Ser Ile Leu Trp Met Cys Ser Thr Leu Ile 
1               5                   10                  15      


Val Thr His Ala Leu His Lys Val Lys Val Gly Lys Ser Pro Pro Val 
            20                  25                  30          


Arg Gly Ser Leu Ser Gly Lys Val Ser Leu Pro Cys His Phe Ser Thr 
        35                  40                  45              


Met Pro Thr Leu Pro Pro Ser Tyr Asn Thr Ser Glu Phe Leu Arg Ile 
    50                  55                  60                  


Lys Trp Ser Lys Ile Glu Val Asp Lys Asn Gly Lys Asp Leu Lys Glu 
65                  70                  75                  80  


Thr Thr Val Leu Val Ala Gln Asn Gly Asn Ile Lys Ile Gly Gln Asp 
                85                  90                  95      


Tyr Lys Gly Arg Val Ser Val Pro Thr His Pro Glu Ala Val Gly Asp 
            100                 105                 110         


Ala Ser Leu Thr Val Val Lys Leu Leu Ala Ser Asp Ala Gly Leu Tyr 
        115                 120                 125             


Arg Cys Asp Val Met Tyr Gly Ile Glu Asp Thr Gln Asp Thr Val Ser 
    130                 135                 140                 


Leu Thr Val Asp Gly Val Val Phe His Tyr Arg Ala Ala Thr Ser Arg 
145                 150                 155                 160 


Tyr Thr Leu Asn Phe Glu Ala Ala Gln Lys Ala Cys Leu Asp Val Gly 
                165                 170                 175     


Ala Val Ile Ala Thr Pro Glu Gln Leu Phe Ala Ala Tyr Glu Asp Gly 
            180                 185                 190         


Phe Glu Gln Cys Asp Ala Gly Trp Leu Ala Asp Gln Thr Val Arg Tyr 
        195                 200                 205             


Pro Ile Arg Ala Pro Arg Val Gly Cys Tyr Gly Asp Lys Met Gly Lys 
    210                 215                 220                 


Ala Gly Val Arg Thr Tyr Gly Phe Arg Ser Pro Gln Glu Thr Tyr Asp 
225                 230                 235                 240 


Val Tyr Cys Tyr Val Asp His Leu Asp Gly Asp Val Phe His Leu Thr 
                245                 250                 255     


Val Pro Ser Lys Phe Thr Phe Glu Glu Ala Ala Lys Glu Cys Glu Asn 
            260                 265                 270         


Gln Asp Ala Arg Leu Ala Thr Val Gly Glu Leu Gln Ala Ala Trp Arg 
        275                 280                 285             


Asn Gly Phe Asp Gln Cys Asp Tyr Gly Trp Leu Ser Asp Ala Ser Val 
    290                 295                 300                 


Arg His Pro Val Thr Val Ala Arg Ala Gln Cys Gly Gly Gly Leu Leu 
305                 310                 315                 320 


Gly Val Arg Thr Leu Tyr Arg Phe Glu Asn Gln Thr Gly Phe Pro Pro 
                325                 330                 335     


Pro Asp Ser Arg Phe Asp Ala Tyr Cys Phe Lys Pro Lys Glu Ala Thr 
            340                 345                 350         


Thr Ile Asp Leu Ser Ile Leu Ala Glu Thr Ala Ser Pro Ser Leu Ser 
        355                 360                 365             


Lys Glu Pro Gln Met Val Ser Asp Arg Thr Thr Pro Ile Ile Pro Leu 
    370                 375                 380                 


Val Asp Glu Leu Pro Val Ile Pro Thr Glu Phe Pro Pro Val Gly Asn 
385                 390                 395                 400 


Ile Val Ser Phe Glu Gln Lys Ala Thr Val Gln Pro Gln Ala Ile Thr 
                405                 410                 415     


Asp Ser Leu Ala Thr Lys Leu Pro Thr Pro Thr Gly Ser Thr Lys Lys 
            420                 425                 430         


Pro Trp Asp Met Asp Asp Tyr Ser Pro Ser Ala Ser Gly Pro Leu Gly 
        435                 440                 445             


Lys Leu Asp Ile Ser Glu Ile Lys Glu Glu Val Leu Gln Ser Thr Thr 
    450                 455                 460                 


Gly Val Ser His Tyr Ala Thr Asp Ser Trp Asp Gly Val Val Glu Asp 
465                 470                 475                 480 


Lys Gln Thr Gln Glu Ser Val Thr Gln Ile Glu Gln Ile Glu Val Gly 
                485                 490                 495     


Pro Leu Val Thr Ser Met Glu Ile Leu Lys His Ile Pro Ser Lys Glu 
            500                 505                 510         


Phe Pro Val Thr Glu Thr Pro Leu Val Thr Ala Arg Met Ile Leu Glu 
        515                 520                 525             


Ser Lys Thr Glu Lys Lys Met Val Ser Thr Val Ser Glu Leu Val Thr 
    530                 535                 540                 


Thr Gly His Tyr Gly Phe Thr Leu Gly Glu Glu Asp Asp Glu Asp Arg 
545                 550                 555                 560 


Thr Leu Thr Val Gly Ser Asp Glu Ser Thr Leu Ile Phe Asp Gln Ile 
                565                 570                 575     


Pro Glu Val Ile Thr Val Ser Lys Thr Ser Glu Asp Thr Ile His Thr 
            580                 585                 590         


His Leu Glu Asp Leu Glu Ser Val Ser Ala Ser Thr Thr Val Ser Pro 
        595                 600                 605             


Leu Ile Met Pro Asp Asn Asn Gly Ser Ser Met Asp Asp Trp Glu Glu 
    610                 615                 620                 


Arg Gln Thr Ser Gly Arg Ile Thr Glu Glu Phe Leu Gly Lys Tyr Leu 
625                 630                 635                 640 


Ser Thr Thr Pro Phe Pro Ser Gln His Arg Thr Glu Ile Glu Leu Phe 
                645                 650                 655     


Pro Tyr Ser Gly Asp Lys Ile Leu Val Glu Gly Ile Ser Thr Val Ile 
            660                 665                 670         


Tyr Pro Ser Leu Gln Thr Glu Met Thr His Arg Arg Glu Arg Thr Glu 
        675                 680                 685             


Thr Leu Ile Pro Glu Met Arg Thr Asp Thr Tyr Thr Asp Glu Ile Gln 
    690                 695                 700                 


Glu Glu Ile Thr Lys Ser Pro Phe Met Gly Lys Thr Glu Glu Glu Val 
705                 710                 715                 720 


Phe Ser Gly Met Lys Leu Ser Thr Ser Leu Ser Glu Pro Ile His Val 
                725                 730                 735     


Thr Glu Ser Ser Val Glu Met Thr Lys Ser Phe Asp Phe Pro Thr Leu 
            740                 745                 750         


Ile Thr Lys Leu Ser Ala Glu Pro Thr Glu Val Arg Asp Met Glu Glu 
        755                 760                 765             


Asp Phe Thr Ala Thr Pro Gly Thr Thr Lys Tyr Asp Glu Asn Ile Thr 
    770                 775                 780                 


Thr Val Leu Leu Ala His Gly Thr Leu Ser Val Glu Ala Ala Thr Val 
785                 790                 795                 800 


Ser Lys Trp Ser Trp Asp Glu Asp Asn Thr Thr Ser Lys Pro Leu Glu 
                805                 810                 815     


Ser Thr Glu Pro Ser Ala Ser Ser Lys Leu Pro Pro Ala Leu Leu Thr 
            820                 825                 830         


Thr Val Gly Met Asn Gly Lys Asp Lys Asp Ile Pro Ser Phe Thr Glu 
        835                 840                 845             


Asp Gly Ala Asp Glu Phe Thr Leu Ile Pro Asp Ser Thr Gln Lys Gln 
    850                 855                 860                 


Leu Glu Glu Val Thr Asp Glu Asp Ile Ala Ala His Gly Lys Phe Thr 
865                 870                 875                 880 


Ile Arg Phe Gln Pro Thr Thr Ser Thr Gly Ile Ala Glu Lys Ser Thr 
                885                 890                 895     


Leu Arg Asp Ser Thr Thr Glu Glu Lys Val Pro Pro Ile Thr Ser Thr 
            900                 905                 910         


Glu Gly Gln Val Tyr Ala Thr Met Glu Gly Ser Ala Leu Gly Glu Val 
        915                 920                 925             


Glu Asp Val Asp Leu Ser Lys Pro Val Ser Thr Val Pro Gln Phe Ala 
    930                 935                 940                 


His Thr Ser Glu Val Glu Gly Leu Ala Phe Val Ser Tyr Ser Ser Thr 
945                 950                 955                 960 


Gln Glu Pro Thr Thr Tyr Val Asp Ser Ser His Thr Ile Pro Leu Ser 
                965                 970                 975     


Val Ile Pro Lys Thr Asp Trp Gly Val Leu Val Pro Ser Val Pro Ser 
            980                 985                 990         


Glu Asp Glu Val Leu Gly Glu Pro  Ser Gln Asp Ile Leu  Val Ile Asp 
        995                 1000                 1005             


Gln Thr  Arg Leu Glu Ala Thr  Ile Ser Pro Glu Thr  Met Arg Thr 
    1010                 1015                 1020             


Thr Lys  Ile Thr Glu Gly Thr  Thr Gln Glu Glu Phe  Pro Trp Lys 
    1025                 1030                 1035             


Glu Gln  Thr Ala Glu Lys Pro  Val Pro Ala Leu Ser  Ser Thr Ala 
    1040                 1045                 1050             


Trp Thr  Pro Lys Glu Ala Val  Thr Pro Leu Asp Glu  Gln Glu Gly 
    1055                 1060                 1065             


Asp Gly  Ser Ala Tyr Thr Val  Ser Glu Asp Glu Leu  Leu Thr Gly 
    1070                 1075                 1080             


Ser Glu  Arg Val Pro Val Leu  Glu Thr Thr Pro Val  Gly Lys Ile 
    1085                 1090                 1095             


Asp His  Ser Val Ser Tyr Pro  Pro Gly Ala Val Thr  Glu His Lys 
    1100                 1105                 1110             


Val Lys  Thr Asp Glu Val Val  Thr Leu Thr Pro Arg  Ile Gly Pro 
    1115                 1120                 1125             


Lys Val  Ser Leu Ser Pro Gly  Pro Glu Gln Lys Tyr  Glu Thr Glu 
    1130                 1135                 1140             


Gly Ser  Ser Thr Thr Gly Phe  Thr Ser Ser Leu Ser  Pro Phe Ser 
    1145                 1150                 1155             


Thr His  Ile Thr Gln Leu Met  Glu Glu Thr Thr Thr  Glu Lys Thr 
    1160                 1165                 1170             


Ser Leu  Glu Asp Ile Asp Leu  Gly Ser Gly Leu Phe  Glu Lys Pro 
    1175                 1180                 1185             


Lys Ala  Thr Glu Leu Ile Glu  Phe Ser Thr Ile Lys  Val Thr Val 
    1190                 1195                 1200             


Pro Ser  Asp Ile Thr Thr Ala  Phe Ser Ser Val Asp  Arg Leu His 
    1205                 1210                 1215             


Thr Thr  Ser Ala Phe Lys Pro  Ser Ser Ala Ile Thr  Lys Lys Pro 
    1220                 1225                 1230             


Pro Leu  Ile Asp Arg Glu Pro  Gly Glu Glu Thr Thr  Ser Asp Met 
    1235                 1240                 1245             


Val Ile  Ile Gly Glu Ser Thr  Ser His Val Pro Pro  Thr Thr Leu 
    1250                 1255                 1260             


Glu Asp  Ile Val Ala Lys Glu  Thr Glu Thr Asp Ile  Asp Arg Glu 
    1265                 1270                 1275             


Tyr Phe  Thr Thr Ser Ser Pro  Pro Ala Thr Gln Pro  Thr Arg Pro 
    1280                 1285                 1290             


Pro Thr  Val Glu Asp Lys Glu  Ala Phe Gly Pro Gln  Ala Leu Ser 
    1295                 1300                 1305             


Thr Pro  Gln Pro Pro Ala Ser  Thr Lys Phe His Pro  Asp Ile Asn 
    1310                 1315                 1320             


Val Tyr  Ile Ile Glu Val Arg  Glu Asn Lys Thr Gly  Arg Met Ser 
    1325                 1330                 1335             


Asp Leu  Ser Val Ile Gly His  Pro Ile Asp Ser Glu  Ser Lys Glu 
    1340                 1345                 1350             


Asp Glu  Pro Cys Ser Glu Glu  Thr Asp Pro Val His  Asp Leu Met 
    1355                 1360                 1365             


Ala Glu  Ile Leu Pro Glu Phe  Pro Asp Ile Ile Glu  Ile Asp Leu 
    1370                 1375                 1380             


Tyr His  Ser Glu Glu Asn Glu  Glu Glu Glu Glu Glu  Cys Ala Asn 
    1385                 1390                 1395             


Ala Thr  Asp Val Thr Thr Thr  Pro Ser Val Gln Tyr  Ile Asn Gly 
    1400                 1405                 1410             


Lys His  Leu Val Thr Thr Val  Pro Lys Asp Pro Glu  Ala Ala Glu 
    1415                 1420                 1425             


Ala Arg  Arg Gly Gln Phe Glu  Ser Val Ala Pro Ser  Gln Asn Phe 
    1430                 1435                 1440             


Ser Asp  Ser Ser Glu Ser Asp  Thr His Pro Phe Val  Ile Ala Lys 
    1445                 1450                 1455             


Thr Glu  Leu Ser Thr Ala Val  Gln Pro Asn Glu Ser  Thr Glu Thr 
    1460                 1465                 1470             


Thr Glu  Ser Leu Glu Val Thr  Trp Lys Pro Glu Thr  Tyr Pro Glu 
    1475                 1480                 1485             


Thr Ser  Glu His Phe Ser Gly  Gly Glu Pro Asp Val  Phe Pro Thr 
    1490                 1495                 1500             


Val Pro  Phe His Glu Glu Phe  Glu Ser Gly Thr Ala  Lys Lys Gly 
    1505                 1510                 1515             


Ala Glu  Ser Val Thr Glu Arg  Asp Thr Glu Val Gly  His Gln Ala 
    1520                 1525                 1530             


His Glu  His Thr Glu Pro Val  Ser Leu Phe Pro Glu  Glu Ser Ser 
    1535                 1540                 1545             


Gly Glu  Ile Ala Ile Asp Gln  Glu Ser Gln Lys Ile  Ala Phe Ala 
    1550                 1555                 1560             


Arg Ala  Thr Glu Val Thr Phe  Gly Glu Glu Val Glu  Lys Ser Thr 
    1565                 1570                 1575             


Ser Val  Thr Tyr Thr Pro Thr  Ile Val Pro Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Tyr Val  Ser Glu Glu Glu Ala  Val Thr Leu Ile Gly  Asn Pro Trp 
    1595                 1600                 1605             


Pro Asp  Asp Leu Leu Ser Thr  Lys Glu Ser Trp Val  Glu Ala Thr 
    1610                 1615                 1620             


Pro Arg  Gln Val Val Glu Leu  Ser Gly Ser Ser Ser  Ile Pro Ile 
    1625                 1630                 1635             


Thr Glu  Gly Ser Gly Glu Ala  Glu Glu Asp Glu Asp  Thr Met Phe 
    1640                 1645                 1650             


Thr Met  Val Thr Asp Leu Ser  Gln Arg Asn Thr Thr  Asp Thr Leu 
    1655                 1660                 1665             


Ile Thr  Leu Asp Thr Ser Arg  Ile Ile Thr Glu Ser  Phe Phe Glu 
    1670                 1675                 1680             


Val Pro  Ala Thr Thr Ile Tyr  Pro Val Ser Glu Gln  Pro Ser Ala 
    1685                 1690                 1695             


Lys Val  Val Pro Thr Lys Phe  Val Ser Glu Thr Asp  Thr Ser Glu 
    1700                 1705                 1710             


Trp Ile  Ser Ser Thr Thr Val  Glu Glu Lys Lys Arg  Lys Glu Glu 
    1715                 1720                 1725             


Glu Gly  Thr Thr Gly Thr Ala  Ser Thr Phe Glu Val  Tyr Ser Ser 
    1730                 1735                 1740             


Thr Gln  Arg Ser Asp Gln Leu  Ile Leu Pro Phe Glu  Leu Glu Ser 
    1745                 1750                 1755             


Pro Asn  Val Ala Thr Ser Ser  Asp Ser Gly Thr Arg  Lys Ser Phe 
    1760                 1765                 1770             


Met Ser  Leu Thr Thr Pro Thr  Gln Ser Glu Arg Glu  Met Thr Asp 
    1775                 1780                 1785             


Ser Thr  Pro Val Phe Thr Glu  Thr Asn Thr Leu Glu  Asn Leu Gly 
    1790                 1795                 1800             


Ala Gln  Thr Thr Glu His Ser  Ser Ile His Gln Pro  Gly Val Gln 
    1805                 1810                 1815             


Glu Gly  Leu Thr Thr Leu Pro  Arg Ser Pro Ala Ser  Val Phe Met 
    1820                 1825                 1830             


Glu Gln  Gly Ser Gly Glu Ala  Ala Ala Asp Pro Glu  Thr Thr Thr 
    1835                 1840                 1845             


Val Ser  Ser Phe Ser Leu Asn  Val Glu Tyr Ala Ile  Gln Ala Glu 
    1850                 1855                 1860             


Lys Glu  Val Ala Gly Thr Leu  Ser Pro His Val Glu  Thr Thr Phe 
    1865                 1870                 1875             


Ser Thr  Glu Pro Thr Gly Leu  Val Leu Ser Thr Val  Met Asp Arg 
    1880                 1885                 1890             


Val Val  Ala Glu Asn Ile Thr  Gln Thr Ser Arg Glu  Ile Val Ile 
    1895                 1900                 1905             


Ser Glu  Arg Leu Gly Glu Pro  Asn Tyr Gly Ala Glu  Ile Arg Gly 
    1910                 1915                 1920             


Phe Ser  Thr Gly Phe Pro Leu  Glu Glu Asp Phe Ser  Gly Asp Phe 
    1925                 1930                 1935             


Arg Glu  Tyr Ser Thr Val Ser  His Pro Ile Ala Lys  Glu Glu Thr 
    1940                 1945                 1950             


Val Met  Met Glu Gly Ser Gly  Asp Ala Ala Phe Arg  Asp Thr Gln 
    1955                 1960                 1965             


Thr Ser  Pro Ser Thr Val Pro  Thr Ser Val His Ile  Ser His Ile 
    1970                 1975                 1980             


Ser Asp  Ser Glu Gly Pro Ser  Ser Thr Met Val Ser  Thr Ser Ala 
    1985                 1990                 1995             


Phe Pro  Trp Glu Glu Phe Thr  Ser Ser Ala Glu Gly  Ser Gly Glu 
    2000                 2005                 2010             


Gln Leu  Val Thr Val Ser Ser  Ser Val Val Pro Val  Leu Pro Ser 
    2015                 2020                 2025             


Ala Val  Gln Lys Phe Ser Gly  Thr Ala Ser Ser Ile  Ile Asp Glu 
    2030                 2035                 2040             


Gly Leu  Gly Glu Val Gly Thr  Val Asn Glu Ile Asp  Arg Arg Ser 
    2045                 2050                 2055             


Thr Ile  Leu Pro Thr Ala Glu  Val Glu Gly Thr Lys  Ala Pro Val 
    2060                 2065                 2070             


Glu Lys  Glu Glu Val Lys Val  Ser Gly Thr Val Ser  Thr Asn Phe 
    2075                 2080                 2085             


Pro Gln  Thr Ile Glu Pro Ala  Lys Leu Trp Ser Arg  Gln Glu Val 
    2090                 2095                 2100             


Asn Pro  Val Arg Gln Glu Ile  Glu Ser Glu Thr Thr  Ser Glu Glu 
    2105                 2110                 2115             


Gln Ile  Gln Glu Glu Lys Ser  Phe Glu Ser Pro Gln  Asn Ser Pro 
    2120                 2125                 2130             


Ala Thr  Glu Gln Thr Ile Phe  Asp Ser Gln Thr Phe  Thr Glu Thr 
    2135                 2140                 2145             


Glu Leu  Lys Thr Thr Asp Tyr  Ser Val Leu Thr Thr  Lys Lys Thr 
    2150                 2155                 2160             


Tyr Ser  Asp Asp Lys Glu Met  Lys Glu Glu Asp Thr  Ser Leu Val 
    2165                 2170                 2175             


Asn Met  Ser Thr Pro Asp Pro  Asp Ala Asn Gly Leu  Glu Ser Tyr 
    2180                 2185                 2190             


Thr Thr  Leu Pro Glu Ala Thr  Glu Lys Ser His Phe  Phe Leu Ala 
    2195                 2200                 2205             


Thr Ala  Leu Val Thr Glu Ser  Ile Pro Ala Glu His  Val Val Thr 
    2210                 2215                 2220             


Asp Ser  Pro Ile Lys Lys Glu  Glu Ser Thr Lys His  Phe Pro Lys 
    2225                 2230                 2235             


Gly Met  Arg Pro Thr Ile Gln  Glu Ser Asp Thr Glu  Leu Leu Phe 
    2240                 2245                 2250             


Ser Gly  Leu Gly Ser Gly Glu  Glu Val Leu Pro Thr  Leu Pro Thr 
    2255                 2260                 2265             


Glu Ser  Val Asn Phe Thr Glu  Val Glu Gln Ile Asn  Asn Thr Leu 
    2270                 2275                 2280             


Tyr Pro  His Thr Ser Gln Val  Glu Ser Thr Ser Ser  Asp Lys Ile 
    2285                 2290                 2295             


Glu Asp  Phe Asn Arg Met Glu  Asn Val Ala Lys Glu  Val Gly Pro 
    2300                 2305                 2310             


Leu Val  Ser Gln Thr Asp Ile  Phe Glu Gly Ser Gly  Ser Val Thr 
    2315                 2320                 2325             


Ser Thr  Thr Leu Ile Glu Ile  Leu Ser Asp Thr Gly  Ala Glu Gly 
    2330                 2335                 2340             


Pro Thr  Val Ala Pro Leu Pro  Phe Ser Thr Asp Ile  Gly His Pro 
    2345                 2350                 2355             


Gln Asn  Gln Thr Val Arg Trp  Ala Glu Glu Ile Gln  Thr Ser Arg 
    2360                 2365                 2370             


Pro Gln  Thr Ile Thr Glu Gln  Asp Ser Asn Lys Asn  Ser Ser Thr 
    2375                 2380                 2385             


Ala Glu  Ile Asn Glu Thr Thr  Thr Ser Ser Thr Asp  Phe Leu Ala 
    2390                 2395                 2400             


Arg Ala  Tyr Gly Phe Glu Met  Ala Lys Glu Phe Val  Thr Ser Ala 
    2405                 2410                 2415             


Pro Lys  Pro Ser Asp Leu Tyr  Tyr Glu Pro Ser Gly  Glu Gly Ser 
    2420                 2425                 2430             


Gly Glu  Val Asp Ile Val Asp  Ser Phe His Thr Ser  Ala Thr Thr 
    2435                 2440                 2445             


Gln Ala  Thr Arg Gln Glu Ser  Ser Thr Thr Phe Val  Ser Asp Gly 
    2450                 2455                 2460             


Ser Leu  Glu Lys His Pro Glu  Val Pro Ser Ala Lys  Ala Val Thr 
    2465                 2470                 2475             


Ala Asp  Gly Phe Pro Thr Val  Ser Val Met Leu Pro  Leu His Ser 
    2480                 2485                 2490             


Glu Gln  Asn Lys Ser Ser Pro  Asp Pro Thr Ser Thr  Leu Ser Asn 
    2495                 2500                 2505             


Thr Val  Ser Tyr Glu Arg Ser  Thr Asp Gly Ser Phe  Gln Asp Arg 
    2510                 2515                 2520             


Phe Arg  Glu Phe Glu Asp Ser  Thr Leu Lys Pro Asn  Arg Lys Lys 
    2525                 2530                 2535             


Pro Thr  Glu Asn Ile Ile Ile  Asp Leu Asp Lys Glu  Asp Lys Asp 
    2540                 2545                 2550             


Leu Ile  Leu Thr Ile Thr Glu  Ser Thr Ile Leu Glu  Ile Leu Pro 
    2555                 2560                 2565             


Glu Leu  Thr Ser Asp Lys Asn  Thr Ile Ile Asp Ile  Asp His Thr 
    2570                 2575                 2580             


Lys Pro  Val Tyr Glu Asp Ile  Leu Gly Met Gln Thr  Asp Ile Asp 
    2585                 2590                 2595             


Thr Glu  Val Pro Ser Glu Pro  His Asp Ser Asn Asp  Glu Ser Asn 
    2600                 2605                 2610             


Asp Asp  Ser Thr Gln Val Gln  Glu Ile Tyr Glu Ala  Ala Val Asn 
    2615                 2620                 2625             


Leu Ser  Leu Thr Glu Glu Thr  Phe Glu Gly Ser Ala  Asp Val Leu 
    2630                 2635                 2640             


Ala Ser  Tyr Thr Gln Ala Thr  His Asp Glu Ser Met  Thr Tyr Glu 
    2645                 2650                 2655             


Asp Arg  Ser Gln Leu Asp His  Met Gly Phe His Phe  Thr Thr Gly 
    2660                 2665                 2670             


Ile Pro  Ala Pro Ser Thr Glu  Thr Glu Leu Asp Val  Leu Leu Pro 
    2675                 2680                 2685             


Thr Ala  Thr Ser Leu Pro Ile  Pro Arg Lys Ser Ala  Thr Val Ile 
    2690                 2695                 2700             


Pro Glu  Ile Glu Gly Ile Lys  Ala Glu Ala Lys Ala  Leu Asp Asp 
    2705                 2710                 2715             


Met Phe  Glu Ser Ser Thr Leu  Ser Asp Gly Gln Ala  Ile Ala Asp 
    2720                 2725                 2730             


Gln Ser  Glu Ile Ile Pro Thr  Leu Gly Gln Phe Glu  Arg Thr Gln 
    2735                 2740                 2745             


Glu Glu  Tyr Glu Asp Lys Lys  His Ala Gly Pro Ser  Phe Gln Pro 
    2750                 2755                 2760             


Glu Phe  Ser Ser Gly Ala Glu  Glu Ala Leu Val Asp  His Thr Pro 
    2765                 2770                 2775             


Tyr Leu  Ser Ile Ala Thr Thr  His Leu Met Asp Gln  Ser Val Thr 
    2780                 2785                 2790             


Glu Val  Pro Asp Val Met Glu  Gly Ser Asn Pro Pro  Tyr Tyr Thr 
    2795                 2800                 2805             


Asp Thr  Thr Leu Ala Val Ser  Thr Phe Ala Lys Leu  Ser Ser Gln 
    2810                 2815                 2820             


Thr Pro  Ser Ser Pro Leu Thr  Ile Tyr Ser Gly Ser  Glu Ala Ser 
    2825                 2830                 2835             


Gly His  Thr Glu Ile Pro Gln  Pro Ser Ala Leu Pro  Gly Ile Asp 
    2840                 2845                 2850             


Val Gly  Ser Ser Val Met Ser  Pro Gln Asp Ser Phe  Lys Glu Ile 
    2855                 2860                 2865             


His Val  Asn Ile Glu Ala Thr  Phe Lys Pro Ser Ser  Glu Glu Tyr 
    2870                 2875                 2880             


Leu His  Ile Thr Glu Pro Pro  Ser Leu Ser Pro Asp  Thr Lys Leu 
    2885                 2890                 2895             


Glu Pro  Ser Glu Asp Asp Gly  Lys Pro Glu Leu Leu  Glu Glu Met 
    2900                 2905                 2910             


Glu Ala  Ser Pro Thr Glu Leu  Ile Ala Val Glu Gly  Thr Glu Ile 
    2915                 2920                 2925             


Leu Gln  Asp Phe Gln Asn Lys  Thr Asp Gly Gln Val  Ser Gly Glu 
    2930                 2935                 2940             


Ala Ile  Lys Met Phe Pro Thr  Ile Lys Thr Pro Glu  Ala Gly Thr 
    2945                 2950                 2955             


Val Ile  Thr Thr Ala Asp Glu  Ile Glu Leu Glu Gly  Ala Thr Gln 
    2960                 2965                 2970             


Trp Pro  His Ser Thr Ser Ala  Ser Ala Thr Tyr Gly  Val Glu Ala 
    2975                 2980                 2985             


Gly Val  Val Pro Trp Leu Ser  Pro Gln Thr Ser Glu  Arg Pro Thr 
    2990                 2995                 3000             


Leu Ser  Ser Ser Pro Glu Ile  Asn Pro Glu Thr Gln  Ala Ala Leu 
    3005                 3010                 3015             


Ile Arg  Gly Gln Asp Ser Thr  Ile Ala Ala Ser Glu  Gln Gln Val 
    3020                 3025                 3030             


Ala Ala  Arg Ile Leu Asp Ser  Asn Asp Gln Ala Thr  Val Asn Pro 
    3035                 3040                 3045             


Val Glu  Phe Asn Thr Glu Val  Ala Thr Pro Pro Phe  Ser Leu Leu 
    3050                 3055                 3060             


Glu Thr  Ser Asn Glu Thr Asp  Phe Leu Ile Gly Ile  Asn Glu Glu 
    3065                 3070                 3075             


Ser Val  Glu Gly Thr Ala Ile  Tyr Leu Pro Gly Pro  Asp Arg Cys 
    3080                 3085                 3090             


Lys Met  Asn Pro Cys Leu Asn  Gly Gly Thr Cys Tyr  Pro Thr Glu 
    3095                 3100                 3105             


Thr Ser  Tyr Val Cys Thr Cys  Val Pro Gly Tyr Ser  Gly Asp Gln 
    3110                 3115                 3120             


Cys Glu  Leu Asp Phe Asp Glu  Cys His Ser Asn Pro  Cys Arg Asn 
    3125                 3130                 3135             


Gly Ala  Thr Cys Val Asp Gly  Phe Asn Thr Phe Arg  Cys Leu Cys 
    3140                 3145                 3150             


Leu Pro  Ser Tyr Val Gly Ala  Leu Cys Glu Gln Asp  Thr Glu Thr 
    3155                 3160                 3165             


Cys Asp  Tyr Gly Trp His Lys  Phe Gln Gly Gln Cys  Tyr Lys Tyr 
    3170                 3175                 3180             


Phe Ala  His Arg Arg Thr Trp  Asp Ala Ala Glu Arg  Glu Cys Arg 
    3185                 3190                 3195             


Leu Gln  Gly Ala His Leu Thr  Ser Ile Leu Ser His  Glu Glu Gln 
    3200                 3205                 3210             


Met Phe  Val Asn Arg Val Gly  His Asp Tyr Gln Trp  Ile Gly Leu 
    3215                 3220                 3225             


Asn Asp  Lys Met Phe Glu His  Asp Phe Arg Trp Thr  Asp Gly Ser 
    3230                 3235                 3240             


Thr Leu  Gln Tyr Glu Asn Trp  Arg Pro Asn Gln Pro  Asp Ser Phe 
    3245                 3250                 3255             


Phe Ser  Ala Gly Glu Asp Cys  Val Val Ile Ile Trp  His Glu Asn 
    3260                 3265                 3270             


Gly Gln  Trp Asn Asp Val Pro  Cys Asn Tyr His Leu  Thr Tyr Thr 
    3275                 3280                 3285             


Cys Lys  Lys Gly Thr Val Ala  Cys Gly Gln Pro Pro  Val Val Glu 
    3290                 3295                 3300             


Asn Ala  Lys Thr Phe Gly Lys  Met Lys Pro Arg Tyr  Glu Ile Asn 
    3305                 3310                 3315             


Ser Leu  Ile Arg Tyr His Cys  Lys Asp Gly Phe Ile  Gln Arg His 
    3320                 3325                 3330             


Leu Pro  Thr Ile Arg Cys Leu  Gly Asn Gly Arg Trp  Ala Ile Pro 
    3335                 3340                 3345             


Lys Ile  Thr Cys Met Asn Pro  Ser Ala Tyr Gln Arg  Thr Tyr Ser 
    3350                 3355                 3360             


Met Lys  Tyr Phe Lys Asn Ser  Ser Ser Ala Lys Asp  Asn Ser Ile 
    3365                 3370                 3375             


Asn Thr  Ser Lys His Asp His  Arg Trp Ser Arg Arg  Trp Gln Glu 
    3380                 3385                 3390             


Ser Arg  Arg 
    3395     


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VCAN_forward primer

<400>  130
tcctgtctca cgaagaacaa                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VCAN_reverse primer

<400>  131
atcagtccaa cggaagtcat                                                   20


<210>  132
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VCAN probe

<400>  132
tcgtgtgggc catgattatc agtgga                                            26


<210>  133
<211>  2465
<212>  DNA
<213>  Homo sapiens

<400>  133
cctttcctcc ctccccgccc tctccccgct gtcccctccc cgtcggcccg cctgcccagc       60

ctttagcctc ccgcccgccg cctctgtctc cctctctcca caaactgccc aggagtgagt      120

agctgctttc ggtccgccgg acacaccgga cagatagacg tgcggacggc ccaccacccc      180

agcccgccaa ctagtcagcc tgcgcctggc gcctcccctc tccaggtcca tccgccatgt      240

ggcccctgtg gcgcctcgtg tctctgctgg ccctgagcca ggccctgccc tttgagcaga      300

gaggcttctg ggacttcacc ctggacgatg ggccattcat gatgaacgat gaggaagctt      360

cgggcgctga cacctcgggc gtcctggacc cggactctgt cacacccacc tacagcgcca      420

tgtgtccttt cggctgccac tgccacctgc gggtggttca gtgctccgac ctgggtctga      480

agtctgtgcc caaagagatc tcccctgaca ccacgctgct ggacctgcag aacaacgaca      540

tctccgagct ccgcaaggat gacttcaagg gtctccagca cctctacgcc ctcgtcctgg      600

tgaacaacaa gatctccaag atccatgaga aggccttcag cccactgcgg aagctgcaga      660

agctctacat ctccaagaac cacctggtgg agatcccgcc caacctaccc agctccctgg      720

tggagctccg catccacgac aaccgcatcc gcaaggtgcc caagggagtg ttcagcgggc      780

tccggaacat gaactgcatc gagatgggcg ggaacccact ggagaacagt ggctttgaac      840

ctggagcctt cgatggcctg aagctcaact acctgcgcat ctcagaggcc aagctgactg      900

gcatccccaa agacctccct gagaccctga atgaactcca cctagaccac aacaaaatcc      960

aggccatcga actggaggac ctgcttcgct actccaagct gtacaggctg ggcctaggcc     1020

acaaccagat caggatgatc gagaacggga gcctgagctt cctgcccacc ctccgggagc     1080

tccacttgga caacaacaag ttggccaggg tgccctcagg gctcccagac ctcaagctcc     1140

tccaggtggt ctatctgcac tccaacaaca tcaccaaagt gggtgtcaac gacttctgtc     1200

ccatgggctt cggggtgaag cgggcctact acaacggcat cagcctcttc aacaaccccg     1260

tgccctactg ggaggtgcag ccggccactt tccgctgcgt cactgaccgc ctggccatcc     1320

agtttggcaa ctacaaaaag tagaggcagc tgcagccacc gcggggcctc agtgggggtc     1380

tctggggaac acagccagac atcctgatgg ggaggcagag ccaggaagct aagccagggc     1440

ccagctgcgt ccaacccagc cccccacctc gggtccctga ccccagctcg atgccccatc     1500

accgcctctc cctggctccc aagggtgcag gtgggcgcaa ggcccggccc ccatcacatg     1560

ttcccttggc ctcagagctg cccctgctct cccaccacag ccacccagag gcaccccatg     1620

aagctttttt ctcgttcact cccaaaccca agtgtccaag gctccagtcc taggagaaca     1680

gtccctgggt cagcagccag gaggcggtcc ataagaatgg ggacagtggg ctctgccagg     1740

gctgccgcac ctgtccagac acacatgttc tgttcctcct cctcatgcat ttccagcctt     1800

tcaaccctcc ccgactctgc ggctcccctc agcccccttg caagttcatg gcctgtccct     1860

cccagacccc tgctccactg gcccttcgac cagtcctccc ttctgttctc tctttccccg     1920

tccttcctct ctctctctct ctctctctct ctctctttct gtgtgtgtgt gtgtgtgtgt     1980

gtgtgtgtgt gtgtgtgtgt gtgtcttgtg cttcctcaga cctttctcgc ttctgagctt     2040

ggtggcctgt tccctccatc tctccgaacc tggcttcgcc tgtccctttc actccacacc     2100

ctctggcctt ctgccttgag ctgggactgc tttctgtctg tccggcctgc acccagcccc     2160

tgcccacaaa accccaggga cagcagtctc cccagcctgc cctgctcagg ccttgccccc     2220

aaacctgtac tgtcccggag gaggttggga ggtggaggcc cagcatcccg cgcagatgac     2280

accatcaacc gccagagtcc cagacaccgg ttttcctaga agcccctcac ccccactggc     2340

ccactggtgg ctaggtctcc ccttatcctt ctggtccagc gcaaggaggg gctgcttctg     2400

aggtcggtgg ctgtctttcc attaaagaaa caccgtgcaa cgtgaaaaaa aaaaaaaaaa     2460

aaaaa                                                                 2465


<210>  134
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Trp Pro Leu Trp Arg Leu Val Ser Leu Leu Ala Leu Ser Gln Ala 
1               5                   10                  15      


Leu Pro Phe Glu Gln Arg Gly Phe Trp Asp Phe Thr Leu Asp Asp Gly 
            20                  25                  30          


Pro Phe Met Met Asn Asp Glu Glu Ala Ser Gly Ala Asp Thr Ser Gly 
        35                  40                  45              


Val Leu Asp Pro Asp Ser Val Thr Pro Thr Tyr Ser Ala Met Cys Pro 
    50                  55                  60                  


Phe Gly Cys His Cys His Leu Arg Val Val Gln Cys Ser Asp Leu Gly 
65                  70                  75                  80  


Leu Lys Ser Val Pro Lys Glu Ile Ser Pro Asp Thr Thr Leu Leu Asp 
                85                  90                  95      


Leu Gln Asn Asn Asp Ile Ser Glu Leu Arg Lys Asp Asp Phe Lys Gly 
            100                 105                 110         


Leu Gln His Leu Tyr Ala Leu Val Leu Val Asn Asn Lys Ile Ser Lys 
        115                 120                 125             


Ile His Glu Lys Ala Phe Ser Pro Leu Arg Lys Leu Gln Lys Leu Tyr 
    130                 135                 140                 


Ile Ser Lys Asn His Leu Val Glu Ile Pro Pro Asn Leu Pro Ser Ser 
145                 150                 155                 160 


Leu Val Glu Leu Arg Ile His Asp Asn Arg Ile Arg Lys Val Pro Lys 
                165                 170                 175     


Gly Val Phe Ser Gly Leu Arg Asn Met Asn Cys Ile Glu Met Gly Gly 
            180                 185                 190         


Asn Pro Leu Glu Asn Ser Gly Phe Glu Pro Gly Ala Phe Asp Gly Leu 
        195                 200                 205             


Lys Leu Asn Tyr Leu Arg Ile Ser Glu Ala Lys Leu Thr Gly Ile Pro 
    210                 215                 220                 


Lys Asp Leu Pro Glu Thr Leu Asn Glu Leu His Leu Asp His Asn Lys 
225                 230                 235                 240 


Ile Gln Ala Ile Glu Leu Glu Asp Leu Leu Arg Tyr Ser Lys Leu Tyr 
                245                 250                 255     


Arg Leu Gly Leu Gly His Asn Gln Ile Arg Met Ile Glu Asn Gly Ser 
            260                 265                 270         


Leu Ser Phe Leu Pro Thr Leu Arg Glu Leu His Leu Asp Asn Asn Lys 
        275                 280                 285             


Leu Ala Arg Val Pro Ser Gly Leu Pro Asp Leu Lys Leu Leu Gln Val 
    290                 295                 300                 


Val Tyr Leu His Ser Asn Asn Ile Thr Lys Val Gly Val Asn Asp Phe 
305                 310                 315                 320 


Cys Pro Met Gly Phe Gly Val Lys Arg Ala Tyr Tyr Asn Gly Ile Ser 
                325                 330                 335     


Leu Phe Asn Asn Pro Val Pro Tyr Trp Glu Val Gln Pro Ala Thr Phe 
            340                 345                 350         


Arg Cys Val Thr Asp Arg Leu Ala Ile Gln Phe Gly Asn Tyr Lys Lys 
        355                 360                 365             


<210>  135
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGN_forward primer

<400>  135
tgcccaaggg agtgttc                                                      17


<210>  136
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGN_reverse primer

<400>  136
tagttgagct tcaggccatc                                                   20


<210>  137
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BGN probe

<400>  137
atgggcggga acccactgga                                                   20


<210>  138
<211>  2537
<212>  DNA
<213>  Homo sapiens

<400>  138
cccagaaggc cgcggggggt ggaccgccta agagggcgtg cgctcccgac atgccccgcg       60

gcgcgccatt aaccgccaga tttgaatcgc gggacccgtt ggcagaggtg gcggcggcgg      120

catgggtgcc ccgacgttgc cccctgcctg gcagcccttt ctcaaggacc accgcatctc      180

tacattcaag aactggccct tcttggaggg ctgcgcctgc accccggagc ggatggccga      240

ggctggcttc atccactgcc ccactgagaa cgagccagac ttggcccagt gtttcttctg      300

cttcaaggag ctggaaggct gggagccaga tgacgacccc atgcaaagga aaccaacaat      360

aagaagaaag aatttgagga aactgcggag aaagtgcgcc gtgccatcga gcagctggct      420

gccatggatt gaggcctctg gccggagctg cctggtccca gagtggctgc accacttcca      480

gggtttattc cctggtgcca ccagccttcc tgtgggcccc ttagcaatgt cttaggaaag      540

gagatcaaca ttttcaaatt agatgtttca actgtgctct tgttttgtct tgaaagtggc      600

accagaggtg cttctgcctg tgcagcgggt gctgctggta acagtggctg cttctctctc      660

tctctctctt ttttgggggc tcatttttgc tgttttgatt cccgggctta ccaggtgaga      720

agtgagggag gaagaaggca gtgtcccttt tgctagagct gacagctttg ttcgcgtggg      780

cagagccttc cacagtgaat gtgtctggac ctcatgttgt tgaggctgtc acagtcctga      840

gtgtggactt ggcaggtgcc tgttgaatct gagctgcagg ttccttatct gtcacacctg      900

tgcctcctca gaggacagtt tttttgttgt tgtgtttttt tgtttttttt tttttggtag      960

atgcatgact tgtgtgtgat gagagaatgg agacagagtc cctggctcct ctactgttta     1020

acaacatggc tttcttattt tgtttgaatt gttaattcac agaatagcac aaactacaat     1080

taaaactaag cacaaagcca ttctaagtca ttggggaaac ggggtgaact tcaggtggat     1140

gaggagacag aatagagtga taggaagcgt ctggcagata ctccttttgc cactgctgtg     1200

tgattagaca ggcccagtga gccgcggggc acatgctggc cgctcctccc tcagaaaaag     1260

gcagtggcct aaatcctttt taaatgactt ggctcgatgc tgtgggggac tggctgggct     1320

gctgcaggcc gtgtgtctgt cagcccaacc ttcacatctg tcacgttctc cacacggggg     1380

agagacgcag tccgcccagg tccccgcttt ctttggaggc agcagctccc gcagggctga     1440

agtctggcgt aagatgatgg atttgattcg ccctcctccc tgtcatagag ctgcagggtg     1500

gattgttaca gcttcgctgg aaacctctgg aggtcatctc ggctgttcct gagaaataaa     1560

aagcctgtca tttcaaacac tgctgtggac cctactgggt ttttaaaata ttgtcagttt     1620

ttcatcgtcg tccctagcct gccaacagcc atctgcccag acagccgcag tgaggatgag     1680

cgtcctggca gagacgcagt tgtctctggg cgcttgccag agccacgaac cccagacctg     1740

tttgtatcat ccgggctcct tccgggcaga aacaactgaa aatgcacttc agacccactt     1800

atttctgcca catctgagtc ggcctgagat agacttttcc ctctaaactg ggagaatatc     1860

acagtggttt ttgttagcag aaaatgcact ccagcctctg tactcatcta agctgcttat     1920

ttttgatatt tgtgtcagtc tgtaaatgga tacttcactt taataactgt tgcttagtaa     1980

ttggctttgt agagaagctg gaaaaaaatg gttttgtctt caactccttt gcatgccagg     2040

cggtgatgtg gatctcggct tctgtgagcc tgtgctgtgg gcagggctga gctggagccg     2100

cccctctcag cccgcctgcc acggcctttc cttaaaggcc atccttaaaa ccagaccctc     2160

atggctacca gcacctgaaa gcttcctcga catctgttaa taaagccgta ggcccttgtc     2220

taagtgcaac cgcctagact ttctttcaga tacatgtcca catgtccatt tttcaggttc     2280

tctaagttgg agtggagtct gggaagggtt gtgaatgagg cttctgggct atgggtgagg     2340

ttccaatggc aggttagagc ccctcgggcc aactgccatc ctggaaagta gagacagcag     2400

tgcccgctgc ccagaagaga ccagcaagcc aaactggagc ccccattgca ggctgtcgcc     2460

atgtggaaag agtaactcac aattgccaat aaagtctcat gtggttttat ctaaaaaaaa     2520

aaaaaaaaaa aaaaaaa                                                    2537


<210>  139
<211>  2724
<212>  DNA
<213>  Homo sapiens

<400>  139
cccagaaggc cgcggggggt ggaccgccta agagggcgtg cgctcccgac atgccccgcg       60

gcgcgccatt aaccgccaga tttgaatcgc gggacccgtt ggcagaggtg gcggcggcgg      120

catgggtgcc ccgacgttgc cccctgcctg gcagcccttt ctcaaggacc accgcatctc      180

tacattcaag aactggccct tcttggaggg ctgcgcctgc accccggagc ggatggccga      240

ggctggcttc atccactgcc ccactgagaa cgagccagac ttggcccagt gtttcttctg      300

cttcaaggag ctggaaggct gggagccaga tgacgacccc attgggccgg gcacggtggc      360

ttacgcctgt aataccagca ctttgggagg ccgaggcggg cggatcacga gagaggaaca      420

taaaaagcat tcgtccggtt gcgctttcct ttctgtcaag aagcagtttg aagaattaac      480

ccttggtgaa tttttgaaac tggacagaga aagagccaag aacaaaattg caaaggaaac      540

caacaataag aagaaagaat ttgaggaaac tgcggagaaa gtgcgccgtg ccatcgagca      600

gctggctgcc atggattgag gcctctggcc ggagctgcct ggtcccagag tggctgcacc      660

acttccaggg tttattccct ggtgccacca gccttcctgt gggcccctta gcaatgtctt      720

aggaaaggag atcaacattt tcaaattaga tgtttcaact gtgctcttgt tttgtcttga      780

aagtggcacc agaggtgctt ctgcctgtgc agcgggtgct gctggtaaca gtggctgctt      840

ctctctctct ctctcttttt tgggggctca tttttgctgt tttgattccc gggcttacca      900

ggtgagaagt gagggaggaa gaaggcagtg tcccttttgc tagagctgac agctttgttc      960

gcgtgggcag agccttccac agtgaatgtg tctggacctc atgttgttga ggctgtcaca     1020

gtcctgagtg tggacttggc aggtgcctgt tgaatctgag ctgcaggttc cttatctgtc     1080

acacctgtgc ctcctcagag gacagttttt ttgttgttgt gtttttttgt tttttttttt     1140

ttggtagatg catgacttgt gtgtgatgag agaatggaga cagagtccct ggctcctcta     1200

ctgtttaaca acatggcttt cttattttgt ttgaattgtt aattcacaga atagcacaaa     1260

ctacaattaa aactaagcac aaagccattc taagtcattg gggaaacggg gtgaacttca     1320

ggtggatgag gagacagaat agagtgatag gaagcgtctg gcagatactc cttttgccac     1380

tgctgtgtga ttagacaggc ccagtgagcc gcggggcaca tgctggccgc tcctccctca     1440

gaaaaaggca gtggcctaaa tcctttttaa atgacttggc tcgatgctgt gggggactgg     1500

ctgggctgct gcaggccgtg tgtctgtcag cccaaccttc acatctgtca cgttctccac     1560

acgggggaga gacgcagtcc gcccaggtcc ccgctttctt tggaggcagc agctcccgca     1620

gggctgaagt ctggcgtaag atgatggatt tgattcgccc tcctccctgt catagagctg     1680

cagggtggat tgttacagct tcgctggaaa cctctggagg tcatctcggc tgttcctgag     1740

aaataaaaag cctgtcattt caaacactgc tgtggaccct actgggtttt taaaatattg     1800

tcagtttttc atcgtcgtcc ctagcctgcc aacagccatc tgcccagaca gccgcagtga     1860

ggatgagcgt cctggcagag acgcagttgt ctctgggcgc ttgccagagc cacgaacccc     1920

agacctgttt gtatcatccg ggctccttcc gggcagaaac aactgaaaat gcacttcaga     1980

cccacttatt tctgccacat ctgagtcggc ctgagataga cttttccctc taaactggga     2040

gaatatcaca gtggtttttg ttagcagaaa atgcactcca gcctctgtac tcatctaagc     2100

tgcttatttt tgatatttgt gtcagtctgt aaatggatac ttcactttaa taactgttgc     2160

ttagtaattg gctttgtaga gaagctggaa aaaaatggtt ttgtcttcaa ctcctttgca     2220

tgccaggcgg tgatgtggat ctcggcttct gtgagcctgt gctgtgggca gggctgagct     2280

ggagccgccc ctctcagccc gcctgccacg gcctttcctt aaaggccatc cttaaaacca     2340

gaccctcatg gctaccagca cctgaaagct tcctcgacat ctgttaataa agccgtaggc     2400

ccttgtctaa gtgcaaccgc ctagactttc tttcagatac atgtccacat gtccattttt     2460

caggttctct aagttggagt ggagtctggg aagggttgtg aatgaggctt ctgggctatg     2520

ggtgaggttc caatggcagg ttagagcccc tcgggccaac tgccatcctg gaaagtagag     2580

acagcagtgc ccgctgccca gaagagacca gcaagccaaa ctggagcccc cattgcaggc     2640

tgtcgccatg tggaaagagt aactcacaat tgccaataaa gtctcatgtg gttttatcta     2700

aaaaaaaaaa aaaaaaaaaa aaaa                                            2724


<210>  140
<211>  2655
<212>  DNA
<213>  Homo sapiens

<400>  140
cccagaaggc cgcggggggt ggaccgccta agagggcgtg cgctcccgac atgccccgcg       60

gcgcgccatt aaccgccaga tttgaatcgc gggacccgtt ggcagaggtg gcggcggcgg      120

catgggtgcc ccgacgttgc cccctgcctg gcagcccttt ctcaaggacc accgcatctc      180

tacattcaag aactggccct tcttggaggg ctgcgcctgc accccggagc ggatggccga      240

ggctggcttc atccactgcc ccactgagaa cgagccagac ttggcccagt gtttcttctg      300

cttcaaggag ctggaaggct gggagccaga tgacgacccc atagaggaac ataaaaagca      360

ttcgtccggt tgcgctttcc tttctgtcaa gaagcagttt gaagaattaa cccttggtga      420

atttttgaaa ctggacagag aaagagccaa gaacaaaatt gcaaaggaaa ccaacaataa      480

gaagaaagaa tttgaggaaa ctgcggagaa agtgcgccgt gccatcgagc agctggctgc      540

catggattga ggcctctggc cggagctgcc tggtcccaga gtggctgcac cacttccagg      600

gtttattccc tggtgccacc agccttcctg tgggcccctt agcaatgtct taggaaagga      660

gatcaacatt ttcaaattag atgtttcaac tgtgctcttg ttttgtcttg aaagtggcac      720

cagaggtgct tctgcctgtg cagcgggtgc tgctggtaac agtggctgct tctctctctc      780

tctctctttt ttgggggctc atttttgctg ttttgattcc cgggcttacc aggtgagaag      840

tgagggagga agaaggcagt gtcccttttg ctagagctga cagctttgtt cgcgtgggca      900

gagccttcca cagtgaatgt gtctggacct catgttgttg aggctgtcac agtcctgagt      960

gtggacttgg caggtgcctg ttgaatctga gctgcaggtt ccttatctgt cacacctgtg     1020

cctcctcaga ggacagtttt tttgttgttg tgtttttttg tttttttttt tttggtagat     1080

gcatgacttg tgtgtgatga gagaatggag acagagtccc tggctcctct actgtttaac     1140

aacatggctt tcttattttg tttgaattgt taattcacag aatagcacaa actacaatta     1200

aaactaagca caaagccatt ctaagtcatt ggggaaacgg ggtgaacttc aggtggatga     1260

ggagacagaa tagagtgata ggaagcgtct ggcagatact ccttttgcca ctgctgtgtg     1320

attagacagg cccagtgagc cgcggggcac atgctggccg ctcctccctc agaaaaaggc     1380

agtggcctaa atccttttta aatgacttgg ctcgatgctg tgggggactg gctgggctgc     1440

tgcaggccgt gtgtctgtca gcccaacctt cacatctgtc acgttctcca cacgggggag     1500

agacgcagtc cgcccaggtc cccgctttct ttggaggcag cagctcccgc agggctgaag     1560

tctggcgtaa gatgatggat ttgattcgcc ctcctccctg tcatagagct gcagggtgga     1620

ttgttacagc ttcgctggaa acctctggag gtcatctcgg ctgttcctga gaaataaaaa     1680

gcctgtcatt tcaaacactg ctgtggaccc tactgggttt ttaaaatatt gtcagttttt     1740

catcgtcgtc cctagcctgc caacagccat ctgcccagac agccgcagtg aggatgagcg     1800

tcctggcaga gacgcagttg tctctgggcg cttgccagag ccacgaaccc cagacctgtt     1860

tgtatcatcc gggctccttc cgggcagaaa caactgaaaa tgcacttcag acccacttat     1920

ttctgccaca tctgagtcgg cctgagatag acttttccct ctaaactggg agaatatcac     1980

agtggttttt gttagcagaa aatgcactcc agcctctgta ctcatctaag ctgcttattt     2040

ttgatatttg tgtcagtctg taaatggata cttcacttta ataactgttg cttagtaatt     2100

ggctttgtag agaagctgga aaaaaatggt tttgtcttca actcctttgc atgccaggcg     2160

gtgatgtgga tctcggcttc tgtgagcctg tgctgtgggc agggctgagc tggagccgcc     2220

cctctcagcc cgcctgccac ggcctttcct taaaggccat ccttaaaacc agaccctcat     2280

ggctaccagc acctgaaagc ttcctcgaca tctgttaata aagccgtagg cccttgtcta     2340

agtgcaaccg cctagacttt ctttcagata catgtccaca tgtccatttt tcaggttctc     2400

taagttggag tggagtctgg gaagggttgt gaatgaggct tctgggctat gggtgaggtt     2460

ccaatggcag gttagagccc ctcgggccaa ctgccatcct ggaaagtaga gacagcagtg     2520

cccgctgccc agaagagacc agcaagccaa actggagccc ccattgcagg ctgtcgccat     2580

gtggaaagag taactcacaa ttgccaataa agtctcatgt ggttttatct aaaaaaaaaa     2640

aaaaaaaaaa aaaaa                                                      2655


<210>  141
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Met Gln Arg Lys Pro Thr Ile 
65                  70                  75                  80  


Arg Arg Lys Asn Leu Arg Lys Leu Arg Arg Lys Cys Ala Val Pro Ser 
                85                  90                  95      


Ser Ser Trp Leu Pro Trp Ile Glu Ala Ser Gly Arg Ser Cys Leu Val 
            100                 105                 110         


Pro Glu Trp Leu His His Phe Gln Gly Leu Phe Pro Gly Ala Thr Ser 
        115                 120                 125             


Leu Pro Val Gly Pro Leu Ala Met Ser 
    130                 135         


<210>  142
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Gly Pro Gly Thr Val Ala 
65                  70                  75                  80  


Tyr Ala Cys Asn Thr Ser Thr Leu Gly Gly Arg Gly Gly Arg Ile Thr 
                85                  90                  95      


Arg Glu Glu His Lys Lys His Ser Ser Gly Cys Ala Phe Leu Ser Val 
            100                 105                 110         


Lys Lys Gln Phe Glu Glu Leu Thr Leu Gly Glu Phe Leu Lys Leu Asp 
        115                 120                 125             


Arg Glu Arg Ala Lys Asn Lys Ile Ala Lys Glu Thr Asn Asn Lys Lys 
    130                 135                 140                 


Lys Glu Phe Glu Glu Thr Ala Glu Lys Val Arg Arg Ala Ile Glu Gln 
145                 150                 155                 160 


Leu Ala Ala Met Asp 
                165 


<210>  143
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  144
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BIRC5_forward primer

<400>  144
cttggcccag tgtttctt                                                     18


<210>  145
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BIRC5_reverse primer

<400>  145
gttcctctat ggggtcgtca t                                                 21


<210>  146
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BIRC5 probe

<400>  146
agctggaagg ctgggagcca                                                   20


<210>  147
<211>  6010
<212>  DNA
<213>  Homo sapiens

<400>  147
cgcgggggcg cgcgcgcgcg ggcccgggag aggctcccga gccaggcggt cttcggtcct       60

cgcagcgctt ccagctcccc gcgcccctat gtgagggaga cggggaggcc cgcggcgcgc      120

aggggagggc gaggcatgtg cacgggccgg agggtgctgc agccgcccga ggaagaggag      180

gacggcggcg aggaggagag cggggggctc gcggcggcgg gccccggccg aggggatgca      240

gtggactgtg tgtgtctggc tgtagcagac gcgaggcggc gacgaggcgc cggggacccg      300

cgcgaggggc ggccgggagg cggcggcggc ggccgccaga agtagcagca ggaccggcgg      360

cggcgacggc agccctgaaa tgcattttcc tctccagcgg ccatgttaac caggaaacct      420

tcggccgccg ctcccgccgc ctacccgacc gattggcggc agtaagcaca caatgaatga      480

tcacctgcat gtcggcagcc acgctcacgg acagatccag gttcaacagt tgtttgagga      540

taacagtaac aagcggacag tgctcacgac acaaccaaat gggcttacaa cagtgggcaa      600

aacgggcttg ccagtggtgc cagagcggca gctggacagc attcatagac ggcaggggag      660

ctccacctct ctaaagtcca tggaaggcat ggggaaggtg aaagccaccc ccatgacacc      720

tgaacaagca atgaagcaat acatgcaaaa actcacagcc ttcgaacacc atgagatttt      780

cagctaccct gaaatatatt tcttgggtct aaatgctaag aagcgccagg gcatgacagg      840

tgggcccaac aatggtggct atgatgatga ccagggatca tatgtgcagg tgccccacga      900

tcacgtggct tacaggtatg aggtcctcaa ggtcattggg aaggggagct ttgggcaggt      960

ggtcaaggcc tacgatcaca aagtccacca gcacgtggcc ctaaagatgg tgcggaatga     1020

gaagcgcttc caccggcaag cagcggagga gatccgaatc ctggaacacc tgcggaagca     1080

ggacaaggat aacacaatga atgtcatcca tatgctggag aatttcacct tccgcaacca     1140

catctgcatg acgtttgagc tgctgagcat gaacctctat gagctcatca agaagaataa     1200

attccagggc ttcagtctgc ctttggttcg caagtttgcc cactcgattc tgcagtgctt     1260

ggatgctttg cacaaaaaca gaataattca ctgtgacctt aagcccgaga acattttgtt     1320

aaagcagcag ggtagaagcg gtattaaagt aattgatttt ggctccagtt gttacgagca     1380

tcagcgtgtc tacacgtaca tccagtcgcg tttttaccgg gctccagaag tgatccttgg     1440

ggccaggtat ggcatgccca ttgatatgtg gagcctgggc tgcattttag cagagctcct     1500

gacgggttac cccctcttgc ctggggaaga tgaaggggac cagctggcct gtatgattga     1560

actgttgggc atgccctcac agaaactgct ggatgcatcc aaacgagcca aaaattttgt     1620

gagctccaag ggttatcccc gttactgcac tgtcacgact ctctcagatg gctctgtggt     1680

cctaaacgga ggccgttccc ggagggggaa actgaggggc ccaccggaga gcagagagtg     1740

ggggaacgcg ctgaaggggt gtgatgatcc ccttttcctt gacttcttaa aacagtgttt     1800

agagtgggat cctgcagtgc gcatgacccc aggccaggct ttgcggcacc cctggctgag     1860

gaggcggttg ccaaagcctc ccaccgggga gaaaacgtca gtgaaaagga taactgagag     1920

caccggtgct atcacatcta tatccaagtt acctccacct tctagctcag cttccaaact     1980

gaggactaat ttggcgcaga tgacagatgc caatgggaat attcagcaga ggacagtgtt     2040

gccaaaactt gttagctgag ctcacgtccc ctgatgctgg taacctgaaa gatacgacat     2100

tgctgagcct tactgggttg aaaaggagta gctcagacct gtttttattt gctcaataac     2160

tctactcatt tgtatctttt cagcacttaa ttttaatgta agaaagttgt tcattttgtt     2220

tttataaaat acatgaggac aatgctttaa gtttttatac tttcagaaac tttttgtgtt     2280

ctaaaagtac aatgagcctt actgtattta gtgtggcaga ataataacat cagtggcagg     2340

ccactgatta cttcatgact gccacgcatt tacagattgg tgtcaaagac attcactatg     2400

tttttatggt tcatgttata tcctccccag ggtgacagcc ccttaaggcc ctccttttcc     2460

ctccatgctc caggtccatg cacaggtgta gcatgtcctg cttccgtttt tcataaatta     2520

atctgggtgt tgggggtagt gggaggagaa cggtcagaat caaagtgaca ttctaagaaa     2580

aactgtacct tagagatttt cctctagtgc tcaaacaaat acaaaataag atccccaagg     2640

tttaaactgc ccagttagca ttctgacatt ctaaaagccg gcaaagcagc ttttagtgga     2700

taaatgggaa tggaaacgtg tgtgttcctc caaattttct agtatgatcg gtgagctgtt     2760

ttgtaaagaa gcctcatatt acagagttgc ttttgcacct aaatttagaa ttgtattcca     2820

tgaactgttc ctcccttttc tctgcttttc tcctctctgt tcctctttta ataccacacg     2880

tctgttgctt gcatttagtt tgtcttcttc cttcagctgt gtatcccaga ctgttaatac     2940

agaaaagaga catttcagct gtgattatga ccattgtttc atattccaat taaaaaaaga     3000

acagcagcct agctacttaa ggtggggatt tccatagttc caaagaagat ttagcagatt     3060

agagtgagtt cacacttttc aggtgccact gtaaggttct ctcagcctgg gaaactatca     3120

actctttctt taaaaagaaa gagggttgaa aatcctctgg acgaacagaa gtcactttgg     3180

ctgttcagta aggccaatgt taacaacacg tttagaggag gaaaagttca acctcaagtt     3240

aaatggtttg acttattctt cgtatcatta gaagaacccc agagatagca ttcctctatt     3300

ttattttact ttcttttgga ttgcactgat tgtttttgtg ggaatgacac tttatctggc     3360

aaagtaactg agagtttggt aaaagaatat tttcttctct gaataataat tattttcaca     3420

gtgaaaattt cagtatttta tcactaatgt atgagcaatg atctatatca atttcaaggc     3480

acgtgaaaaa aattttttag tatgtgcaat ttaatataga aagatttctg cctgtttgga     3540

caataggttt tgggtagtac agattaggat aagtaagctt atatatgcac agagattatt     3600

gtattacctg taaattgatt tacaagtact taaaagcgtg gtccccagtg aggccaagaa     3660

agtttccggt taagttcttt aataataatc ctacagttta tcttaagaaa aaaaaaaagg     3720

tttgaaaaaa acactttaat ttaggcttcg ttggttgatg gtggaaaaaa atgctcagga     3780

aatatttcag atatttgcca aaaaaccagt aataaggtta ccttattaaa atagtgatat     3840

ttgctttact atttaaggtg tcactgataa attaatttgt acttctgtgt ttagaaatta     3900

tagcttcttt tcccttagtc aaatttttta gcatattata cacatttctg tgtaatctgt     3960

ggaagtgcaa taatatgtta gtaagttaca ttttaaataa tgctcatgtg acaatactcc     4020

caatcaatgg cttatagaat ttaaagatct gtatattaga ttttggctta aaggcatgag     4080

aagtataaga cttggtttgg tggctttgta agaccaccag cctcttaatg atggttagct     4140

tctttaggtc attaaatcaa taaaaacata taatgctgtt ttgctcttct aatgctcctc     4200

ttccatttcc agttatcttc acatttacat ttaaatatac aaacctgagc ctgccattat     4260

taatttccct ataaaatgac gatacatgtg aacatttata aatggactaa tactgcttgt     4320

ctttccccca ccgcacaaaa ctggttctta agatgccagc aatgaatttg agactatctt     4380

tatttataaa tggaaaccgg aaacttttat accaaactat aataatgtgc agcactgtag     4440

ggcttttttt tttttccctc caaatacagt gaaatttttt tattcacaag agctgccaca     4500

tctcagcatt tagtaataga gctgctttaa taaaattcta gtttgattgt catgtcaaaa     4560

aaagaaaaat gttgcatctt tgtgatttta aaacataaat taatgaaggc tctgataggc     4620

tattaggagt tggcttggaa acagtttttg gtctcacagg ttaccattgt ttggggatgt     4680

ctgagctgtt ttcagatcta ggaatagcac agtgttgtct tgtctttggc agtctcattt     4740

ggctctgttt cttgcaccac cagcgtgttc attaccactt aaatatattg ctacagcagt     4800

ggaacaacag agtggtgcaa gacactgtag attaacggta gaggagaaat tgtgccctta     4860

gtgttaacaa tgtgcctttt gttctgaatg ccatgttgta gggcatgcat tttttggcct     4920

ctttaactct tcgaattcta gtcagtaaga atggaaccca tctctgcaaa gatacatctg     4980

tcttaaatat ctagttacag gccttaatag aaaccataag gcatgactca tcttcaggca     5040

ctgaaaaaag ataaccatca ggtagtgtta cacaaggact tcctatattt aaggggttaa     5100

agatggtctt tgttgtatct taacatcaga ctgattttta catttttttt ttgttatgct     5160

aacactagac aaaaatcaac tgtatttgta aaaatttacc tcaaaccatt taattttata     5220

gtgtgattaa tcccagggca tttggtatga accaaagtgc attcctttta tatgtgcctg     5280

gctctagtaa ggatggccag ggatttttac aatttgggtg caaggcactt aagccacttt     5340

taaacttaat gggtggtttg gggtcgtgtt aaatgactcc atcagaatgt tagaaaacac     5400

tttaggcatc agtagcattg ggccatattg gaatcctaaa gtgtgaatta ttttaaggag     5460

agcattcatt tttgtaattt ttttcatcaa aaatatttct ggtaagcaga agacttttta     5520

aaaaaactga tctggtctcg gtaaaggttt taatattgcc caacataatg ctgtaatagc     5580

attaaaaaaa gtatttgtga actctgtttc ttaggggctt gtacatctct ctgctatgga     5640

catacataaa attaattgta attatactca gctcaactgc tacagttctg tctaggcagt     5700

ggcttgggtt tttatcgagc aacaacttag acacgtgact gtaatatgct gcaactgtgt     5760

gtactgaaaa tatgtgaaaa tggttgaatg tggactgtgt atatatgtat gtaaaaattt     5820

ctgtgagatg ctgctgtcgc cacttaacat taaatatgtt ctagtggatt ttaatcctag     5880

tggccagttc tatgatactg tatgtattat acagctgatg acaggagtaa gactgtttag     5940

tgaatatctg ttaaatttta ttgttgtggc cagagataat ttcagaataa aattttaatg     6000

tcctacctta                                                            6010


<210>  148
<211>  6159
<212>  DNA
<213>  Homo sapiens

<400>  148
cgcgggggcg cgcgcgcgcg ggcccgggag aggctcccga gccaggcggt cttcggtcct       60

cgcagcgctt ccagctcccc gcgcccctat gtgagggaga cggggaggcc cgcggcgcgc      120

aggggagggc gaggcatgtg cacgggccgg agggtgctgc agccgcccga ggaagaggag      180

gacggcggcg aggaggagag cggggggctc gcggcggcgg gccccggccg aggggatgca      240

gtggactgtg tgtgtctggc tgtagcagac gcgaggcggc gacgaggcgc cggggacccg      300

cgcgaggggc ggccgggagg cggcggcggc ggccgccaga agtagcagca ggaccggcgg      360

cggcgacggc agccctgaaa tgcattttcc tctccagcgg ccatgttaac caggaaacct      420

tcggccgccg ctcccgccgc ctacccgacc ggccgaggtg gggacagcgc cgttcgtcag      480

cttcaggctt ccccggggct cggtgcaggg gccacccgga gcggagtggg gactggcccg      540

ccctccccca tcgccctgcc gcctctccgg gccagcaacg ctgccgccgc agcccacacg      600

attggcggca gtaagcacac aatgaatgat cacctgcatg tcggcagcca cgctcacgga      660

cagatccagg ttcaacagtt gtttgaggat aacagtaaca agcggacagt gctcacgaca      720

caaccaaatg ggcttacaac agtgggcaaa acgggcttgc cagtggtgcc agagcggcag      780

ctggacagca ttcatagacg gcaggggagc tccacctctc taaagtccat ggaaggcatg      840

gggaaggtga aagccacccc catgacacct gaacaagcaa tgaagcaata catgcaaaaa      900

ctcacagcct tcgaacacca tgagattttc agctaccctg aaatatattt cttgggtcta      960

aatgctaaga agcgccaggg catgacaggt gggcccaaca atggtggcta tgatgatgac     1020

cagggatcat atgtgcaggt gccccacgat cacgtggctt acaggtatga ggtcctcaag     1080

gtcattggga aggggagctt tgggcaggtg gtcaaggcct acgatcacaa agtccaccag     1140

cacgtggccc taaagatggt gcggaatgag aagcgcttcc accggcaagc agcggaggag     1200

atccgaatcc tggaacacct gcggaagcag gacaaggata acacaatgaa tgtcatccat     1260

atgctggaga atttcacctt ccgcaaccac atctgcatga cgtttgagct gctgagcatg     1320

aacctctatg agctcatcaa gaagaataaa ttccagggct tcagtctgcc tttggttcgc     1380

aagtttgccc actcgattct gcagtgcttg gatgctttgc acaaaaacag aataattcac     1440

tgtgacctta agcccgagaa cattttgtta aagcagcagg gtagaagcgg tattaaagta     1500

attgattttg gctccagttg ttacgagcat cagcgtgtct acacgtacat ccagtcgcgt     1560

ttttaccggg ctccagaagt gatccttggg gccaggtatg gcatgcccat tgatatgtgg     1620

agcctgggct gcattttagc agagctcctg acgggttacc ccctcttgcc tggggaagat     1680

gaaggggacc agctggcctg tatgattgaa ctgttgggca tgccctcaca gaaactgctg     1740

gatgcatcca aacgagccaa aaattttgtg agctccaagg gttatccccg ttactgcact     1800

gtcacgactc tctcagatgg ctctgtggtc ctaaacggag gccgttcccg gagggggaaa     1860

ctgaggggcc caccggagag cagagagtgg gggaacgcgc tgaaggggtg tgatgatccc     1920

cttttccttg acttcttaaa acagtgttta gagtgggatc ctgcagtgcg catgacccca     1980

ggccaggctt tgcggcaccc ctggctgagg aggcggttgc caaagcctcc caccggggag     2040

aaaacgtcag tgaaaaggat aactgagagc accggtgcta tcacatctat atccaagtta     2100

cctccacctt ctagctcagc ttccaaactg aggactaatt tggcgcagat gacagatgcc     2160

aatgggaata ttcagcagag gacagtgttg ccaaaacttg ttagctgagc tcacgtcccc     2220

tgatgctggt aacctgaaag atacgacatt gctgagcctt actgggttga aaaggagtag     2280

ctcagacctg tttttatttg ctcaataact ctactcattt gtatcttttc agcacttaat     2340

tttaatgtaa gaaagttgtt cattttgttt ttataaaata catgaggaca atgctttaag     2400

tttttatact ttcagaaact ttttgtgttc taaaagtaca atgagcctta ctgtatttag     2460

tgtggcagaa taataacatc agtggcaggc cactgattac ttcatgactg ccacgcattt     2520

acagattggt gtcaaagaca ttcactatgt ttttatggtt catgttatat cctccccagg     2580

gtgacagccc cttaaggccc tccttttccc tccatgctcc aggtccatgc acaggtgtag     2640

catgtcctgc ttccgttttt cataaattaa tctgggtgtt gggggtagtg ggaggagaac     2700

ggtcagaatc aaagtgacat tctaagaaaa actgtacctt agagattttc ctctagtgct     2760

caaacaaata caaaataaga tccccaaggt ttaaactgcc cagttagcat tctgacattc     2820

taaaagccgg caaagcagct tttagtggat aaatgggaat ggaaacgtgt gtgttcctcc     2880

aaattttcta gtatgatcgg tgagctgttt tgtaaagaag cctcatatta cagagttgct     2940

tttgcaccta aatttagaat tgtattccat gaactgttcc tcccttttct ctgcttttct     3000

cctctctgtt cctcttttaa taccacacgt ctgttgcttg catttagttt gtcttcttcc     3060

ttcagctgtg tatcccagac tgttaataca gaaaagagac atttcagctg tgattatgac     3120

cattgtttca tattccaatt aaaaaaagaa cagcagccta gctacttaag gtggggattt     3180

ccatagttcc aaagaagatt tagcagatta gagtgagttc acacttttca ggtgccactg     3240

taaggttctc tcagcctggg aaactatcaa ctctttcttt aaaaagaaag agggttgaaa     3300

atcctctgga cgaacagaag tcactttggc tgttcagtaa ggccaatgtt aacaacacgt     3360

ttagaggagg aaaagttcaa cctcaagtta aatggtttga cttattcttc gtatcattag     3420

aagaacccca gagatagcat tcctctattt tattttactt tcttttggat tgcactgatt     3480

gtttttgtgg gaatgacact ttatctggca aagtaactga gagtttggta aaagaatatt     3540

ttcttctctg aataataatt attttcacag tgaaaatttc agtattttat cactaatgta     3600

tgagcaatga tctatatcaa tttcaaggca cgtgaaaaaa attttttagt atgtgcaatt     3660

taatatagaa agatttctgc ctgtttggac aataggtttt gggtagtaca gattaggata     3720

agtaagctta tatatgcaca gagattattg tattacctgt aaattgattt acaagtactt     3780

aaaagcgtgg tccccagtga ggccaagaaa gtttccggtt aagttcttta ataataatcc     3840

tacagtttat cttaagaaaa aaaaaaaggt ttgaaaaaaa cactttaatt taggcttcgt     3900

tggttgatgg tggaaaaaaa tgctcaggaa atatttcaga tatttgccaa aaaaccagta     3960

ataaggttac cttattaaaa tagtgatatt tgctttacta tttaaggtgt cactgataaa     4020

ttaatttgta cttctgtgtt tagaaattat agcttctttt cccttagtca aattttttag     4080

catattatac acatttctgt gtaatctgtg gaagtgcaat aatatgttag taagttacat     4140

tttaaataat gctcatgtga caatactccc aatcaatggc ttatagaatt taaagatctg     4200

tatattagat tttggcttaa aggcatgaga agtataagac ttggtttggt ggctttgtaa     4260

gaccaccagc ctcttaatga tggttagctt ctttaggtca ttaaatcaat aaaaacatat     4320

aatgctgttt tgctcttcta atgctcctct tccatttcca gttatcttca catttacatt     4380

taaatataca aacctgagcc tgccattatt aatttcccta taaaatgacg atacatgtga     4440

acatttataa atggactaat actgcttgtc tttcccccac cgcacaaaac tggttcttaa     4500

gatgccagca atgaatttga gactatcttt atttataaat ggaaaccgga aacttttata     4560

ccaaactata ataatgtgca gcactgtagg gctttttttt ttttccctcc aaatacagtg     4620

aaattttttt attcacaaga gctgccacat ctcagcattt agtaatagag ctgctttaat     4680

aaaattctag tttgattgtc atgtcaaaaa aagaaaaatg ttgcatcttt gtgattttaa     4740

aacataaatt aatgaaggct ctgataggct attaggagtt ggcttggaaa cagtttttgg     4800

tctcacaggt taccattgtt tggggatgtc tgagctgttt tcagatctag gaatagcaca     4860

gtgttgtctt gtctttggca gtctcatttg gctctgtttc ttgcaccacc agcgtgttca     4920

ttaccactta aatatattgc tacagcagtg gaacaacaga gtggtgcaag acactgtaga     4980

ttaacggtag aggagaaatt gtgcccttag tgttaacaat gtgccttttg ttctgaatgc     5040

catgttgtag ggcatgcatt ttttggcctc tttaactctt cgaattctag tcagtaagaa     5100

tggaacccat ctctgcaaag atacatctgt cttaaatatc tagttacagg ccttaataga     5160

aaccataagg catgactcat cttcaggcac tgaaaaaaga taaccatcag gtagtgttac     5220

acaaggactt cctatattta aggggttaaa gatggtcttt gttgtatctt aacatcagac     5280

tgatttttac attttttttt tgttatgcta acactagaca aaaatcaact gtatttgtaa     5340

aaatttacct caaaccattt aattttatag tgtgattaat cccagggcat ttggtatgaa     5400

ccaaagtgca ttccttttat atgtgcctgg ctctagtaag gatggccagg gatttttaca     5460

atttgggtgc aaggcactta agccactttt aaacttaatg ggtggtttgg ggtcgtgtta     5520

aatgactcca tcagaatgtt agaaaacact ttaggcatca gtagcattgg gccatattgg     5580

aatcctaaag tgtgaattat tttaaggaga gcattcattt ttgtaatttt tttcatcaaa     5640

aatatttctg gtaagcagaa gactttttaa aaaaactgat ctggtctcgg taaaggtttt     5700

aatattgccc aacataatgc tgtaatagca ttaaaaaaag tatttgtgaa ctctgtttct     5760

taggggcttg tacatctctc tgctatggac atacataaaa ttaattgtaa ttatactcag     5820

ctcaactgct acagttctgt ctaggcagtg gcttgggttt ttatcgagca acaacttaga     5880

cacgtgactg taatatgctg caactgtgtg tactgaaaat atgtgaaaat ggttgaatgt     5940

ggactgtgta tatatgtatg taaaaatttc tgtgagatgc tgctgtcgcc acttaacatt     6000

aaatatgttc tagtggattt taatcctagt ggccagttct atgatactgt atgtattata     6060

cagctgatga caggagtaag actgtttagt gaatatctgt taaattttat tgttgtggcc     6120

agagataatt tcagaataaa attttaatgt cctacctta                            6159


<210>  149
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Asn Asp His Leu His Val Gly Ser His Ala His Gly Gln Ile Gln 
1               5                   10                  15      


Val Gln Gln Leu Phe Glu Asp Asn Ser Asn Lys Arg Thr Val Leu Thr 
            20                  25                  30          


Thr Gln Pro Asn Gly Leu Thr Thr Val Gly Lys Thr Gly Leu Pro Val 
        35                  40                  45              


Val Pro Glu Arg Gln Leu Asp Ser Ile His Arg Arg Gln Gly Ser Ser 
    50                  55                  60                  


Thr Ser Leu Lys Ser Met Glu Gly Met Gly Lys Val Lys Ala Thr Pro 
65                  70                  75                  80  


Met Thr Pro Glu Gln Ala Met Lys Gln Tyr Met Gln Lys Leu Thr Ala 
                85                  90                  95      


Phe Glu His His Glu Ile Phe Ser Tyr Pro Glu Ile Tyr Phe Leu Gly 
            100                 105                 110         


Leu Asn Ala Lys Lys Arg Gln Gly Met Thr Gly Gly Pro Asn Asn Gly 
        115                 120                 125             


Gly Tyr Asp Asp Asp Gln Gly Ser Tyr Val Gln Val Pro His Asp His 
    130                 135                 140                 


Val Ala Tyr Arg Tyr Glu Val Leu Lys Val Ile Gly Lys Gly Ser Phe 
145                 150                 155                 160 


Gly Gln Val Val Lys Ala Tyr Asp His Lys Val His Gln His Val Ala 
                165                 170                 175     


Leu Lys Met Val Arg Asn Glu Lys Arg Phe His Arg Gln Ala Ala Glu 
            180                 185                 190         


Glu Ile Arg Ile Leu Glu His Leu Arg Lys Gln Asp Lys Asp Asn Thr 
        195                 200                 205             


Met Asn Val Ile His Met Leu Glu Asn Phe Thr Phe Arg Asn His Ile 
    210                 215                 220                 


Cys Met Thr Phe Glu Leu Leu Ser Met Asn Leu Tyr Glu Leu Ile Lys 
225                 230                 235                 240 


Lys Asn Lys Phe Gln Gly Phe Ser Leu Pro Leu Val Arg Lys Phe Ala 
                245                 250                 255     


His Ser Ile Leu Gln Cys Leu Asp Ala Leu His Lys Asn Arg Ile Ile 
            260                 265                 270         


His Cys Asp Leu Lys Pro Glu Asn Ile Leu Leu Lys Gln Gln Gly Arg 
        275                 280                 285             


Ser Gly Ile Lys Val Ile Asp Phe Gly Ser Ser Cys Tyr Glu His Gln 
    290                 295                 300                 


Arg Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr Arg Ala Pro Glu Val 
305                 310                 315                 320 


Ile Leu Gly Ala Arg Tyr Gly Met Pro Ile Asp Met Trp Ser Leu Gly 
                325                 330                 335     


Cys Ile Leu Ala Glu Leu Leu Thr Gly Tyr Pro Leu Leu Pro Gly Glu 
            340                 345                 350         


Asp Glu Gly Asp Gln Leu Ala Cys Met Ile Glu Leu Leu Gly Met Pro 
        355                 360                 365             


Ser Gln Lys Leu Leu Asp Ala Ser Lys Arg Ala Lys Asn Phe Val Ser 
    370                 375                 380                 


Ser Lys Gly Tyr Pro Arg Tyr Cys Thr Val Thr Thr Leu Ser Asp Gly 
385                 390                 395                 400 


Ser Val Val Leu Asn Gly Gly Arg Ser Arg Arg Gly Lys Leu Arg Gly 
                405                 410                 415     


Pro Pro Glu Ser Arg Glu Trp Gly Asn Ala Leu Lys Gly Cys Asp Asp 
            420                 425                 430         


Pro Leu Phe Leu Asp Phe Leu Lys Gln Cys Leu Glu Trp Asp Pro Ala 
        435                 440                 445             


Val Arg Met Thr Pro Gly Gln Ala Leu Arg His Pro Trp Leu Arg Arg 
    450                 455                 460                 


Arg Leu Pro Lys Pro Pro Thr Gly Glu Lys Thr Ser Val Lys Arg Ile 
465                 470                 475                 480 


Thr Glu Ser Thr Gly Ala Ile Thr Ser Ile Ser Lys Leu Pro Pro Pro 
                485                 490                 495     


Ser Ser Ser Ala Ser Lys Leu Arg Thr Asn Leu Ala Gln Met Thr Asp 
            500                 505                 510         


Ala Asn Gly Asn Ile Gln Gln Arg Thr Val Leu Pro Lys Leu Val Ser 
        515                 520                 525             


<210>  150
<211>  601
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Leu Thr Arg Lys Pro Ser Ala Ala Ala Pro Ala Ala Tyr Pro Thr 
1               5                   10                  15      


Gly Arg Gly Gly Asp Ser Ala Val Arg Gln Leu Gln Ala Ser Pro Gly 
            20                  25                  30          


Leu Gly Ala Gly Ala Thr Arg Ser Gly Val Gly Thr Gly Pro Pro Ser 
        35                  40                  45              


Pro Ile Ala Leu Pro Pro Leu Arg Ala Ser Asn Ala Ala Ala Ala Ala 
    50                  55                  60                  


His Thr Ile Gly Gly Ser Lys His Thr Met Asn Asp His Leu His Val 
65                  70                  75                  80  


Gly Ser His Ala His Gly Gln Ile Gln Val Gln Gln Leu Phe Glu Asp 
                85                  90                  95      


Asn Ser Asn Lys Arg Thr Val Leu Thr Thr Gln Pro Asn Gly Leu Thr 
            100                 105                 110         


Thr Val Gly Lys Thr Gly Leu Pro Val Val Pro Glu Arg Gln Leu Asp 
        115                 120                 125             


Ser Ile His Arg Arg Gln Gly Ser Ser Thr Ser Leu Lys Ser Met Glu 
    130                 135                 140                 


Gly Met Gly Lys Val Lys Ala Thr Pro Met Thr Pro Glu Gln Ala Met 
145                 150                 155                 160 


Lys Gln Tyr Met Gln Lys Leu Thr Ala Phe Glu His His Glu Ile Phe 
                165                 170                 175     


Ser Tyr Pro Glu Ile Tyr Phe Leu Gly Leu Asn Ala Lys Lys Arg Gln 
            180                 185                 190         


Gly Met Thr Gly Gly Pro Asn Asn Gly Gly Tyr Asp Asp Asp Gln Gly 
        195                 200                 205             


Ser Tyr Val Gln Val Pro His Asp His Val Ala Tyr Arg Tyr Glu Val 
    210                 215                 220                 


Leu Lys Val Ile Gly Lys Gly Ser Phe Gly Gln Val Val Lys Ala Tyr 
225                 230                 235                 240 


Asp His Lys Val His Gln His Val Ala Leu Lys Met Val Arg Asn Glu 
                245                 250                 255     


Lys Arg Phe His Arg Gln Ala Ala Glu Glu Ile Arg Ile Leu Glu His 
            260                 265                 270         


Leu Arg Lys Gln Asp Lys Asp Asn Thr Met Asn Val Ile His Met Leu 
        275                 280                 285             


Glu Asn Phe Thr Phe Arg Asn His Ile Cys Met Thr Phe Glu Leu Leu 
    290                 295                 300                 


Ser Met Asn Leu Tyr Glu Leu Ile Lys Lys Asn Lys Phe Gln Gly Phe 
305                 310                 315                 320 


Ser Leu Pro Leu Val Arg Lys Phe Ala His Ser Ile Leu Gln Cys Leu 
                325                 330                 335     


Asp Ala Leu His Lys Asn Arg Ile Ile His Cys Asp Leu Lys Pro Glu 
            340                 345                 350         


Asn Ile Leu Leu Lys Gln Gln Gly Arg Ser Gly Ile Lys Val Ile Asp 
        355                 360                 365             


Phe Gly Ser Ser Cys Tyr Glu His Gln Arg Val Tyr Thr Tyr Ile Gln 
    370                 375                 380                 


Ser Arg Phe Tyr Arg Ala Pro Glu Val Ile Leu Gly Ala Arg Tyr Gly 
385                 390                 395                 400 


Met Pro Ile Asp Met Trp Ser Leu Gly Cys Ile Leu Ala Glu Leu Leu 
                405                 410                 415     


Thr Gly Tyr Pro Leu Leu Pro Gly Glu Asp Glu Gly Asp Gln Leu Ala 
            420                 425                 430         


Cys Met Ile Glu Leu Leu Gly Met Pro Ser Gln Lys Leu Leu Asp Ala 
        435                 440                 445             


Ser Lys Arg Ala Lys Asn Phe Val Ser Ser Lys Gly Tyr Pro Arg Tyr 
    450                 455                 460                 


Cys Thr Val Thr Thr Leu Ser Asp Gly Ser Val Val Leu Asn Gly Gly 
465                 470                 475                 480 


Arg Ser Arg Arg Gly Lys Leu Arg Gly Pro Pro Glu Ser Arg Glu Trp 
                485                 490                 495     


Gly Asn Ala Leu Lys Gly Cys Asp Asp Pro Leu Phe Leu Asp Phe Leu 
            500                 505                 510         


Lys Gln Cys Leu Glu Trp Asp Pro Ala Val Arg Met Thr Pro Gly Gln 
        515                 520                 525             


Ala Leu Arg His Pro Trp Leu Arg Arg Arg Leu Pro Lys Pro Pro Thr 
    530                 535                 540                 


Gly Glu Lys Thr Ser Val Lys Arg Ile Thr Glu Ser Thr Gly Ala Ile 
545                 550                 555                 560 


Thr Ser Ile Ser Lys Leu Pro Pro Pro Ser Ser Ser Ala Ser Lys Leu 
                565                 570                 575     


Arg Thr Asn Leu Ala Gln Met Thr Asp Ala Asn Gly Asn Ile Gln Gln 
            580                 585                 590         


Arg Thr Val Leu Pro Lys Leu Val Ser 
        595                 600     


<210>  151
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DYRK2_forward primer

<400>  151
cggccatgtt aaccaggaaa c                                                 21


<210>  152
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DYRK2_reverse primer

<400>  152
cgacatgcag gtgatcattc                                                   20


<210>  153
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DYRK2 probe

<400>  153
cgattggcgg cagtaagcac acaa                                              24


<210>  154
<211>  1921
<212>  DNA
<213>  Homo sapiens

<400>  154
ggcggaagtg acattatcaa cgcgcgccag gggttcagtg aggtcgggca ggttcgctgt       60

ggcgggcgcc tgggccgccg gctgtttaac ttcgcttccg ctggcccata gtgatctttg      120

cagtgaccca gcatcactgt ttcttggcgt gtgaagataa cccaaggaat tgaggaagtt      180

gctgagaaga gtgtgctgga gatgctctag gaaaaaattg aatagtgaga cgagttccag      240

cgcaagggtt tctggtttgc caagaagaaa gtgaacatca tggatcagaa caacagcctg      300

ccaccttacg ctcagggctt ggcctcccct cagggtgcca tgactcccgg aatccctatc      360

tttagtccaa tgatgcctta tggcactgga ctgaccccac agcctattca gaacaccaat      420

agtctgtcta ttttggaaga gcaacaaagg cagcagcagc aacaacaaca gcagcagcag      480

cagcagcagc agcaacagca acagcagcag cagcagcagc agcagcagca gcagcagcag      540

cagcagcagc agcagcagca acaggcagtg gcagctgcag ccgttcagca gtcaacgtcc      600

cagcaggcaa cacagggaac ctcaggccag gcaccacagc tcttccactc acagactctc      660

acaactgcac ccttgccggg caccactcca ctgtatccct cccccatgac tcccatgacc      720

cccatcactc ctgccacgcc agcttcggag agttctggga ttgtaccgca gctgcaaaat      780

attgtatcca cagtgaatct tggttgtaaa cttgacctaa agaccattgc acttcgtgcc      840

cgaaacgccg aatataatcc caagcggttt gctgcggtaa tcatgaggat aagagagcca      900

cgaaccacgg cactgatttt cagttctggg aaaatggtgt gcacaggagc caagagtgaa      960

gaacagtcca gactggcagc aagaaaatat gctagagttg tacagaagtt gggttttcca     1020

gctaagttct tggacttcaa gattcagaat atggtgggga gctgtgatgt gaagtttcct     1080

ataaggttag aaggccttgt gctcacccac caacaattta gtagttatga gccagagtta     1140

tttcctggtt taatctacag aatgatcaaa cccagaattg ttctccttat ttttgtttct     1200

ggaaaagttg tattaacagg tgctaaagtc agagcagaaa tttatgaagc atttgaaaac     1260

atctacccta ttctaaaggg attcaggaag acgacgtaat ggctctcatg tacccttgcc     1320

tcccccaccc ccttcttttt ttttttttaa acaaatcagt ttgttttggt acctttaaat     1380

ggtggtgttg tgagaagatg gatgttgagt tgcagggtgt ggcaccaggt gatgcccttc     1440

tgtaagtgcc caccgcggga tgccgggaag gggcattatt tgtgcactga gaacaccgcg     1500

cagcgtgact gtgagttgct cataccgtgc tgctatctgg gcagcgctgc ccatttattt     1560

atatgtagat tttaaacact gctgttgaca agttggtttg agggagaaaa ctttaagtgt     1620

taaagccacc tctataattg attggacttt ttaattttaa tgtttttccc catgaaccac     1680

agtttttata tttctaccag aaaagtaaaa atctttttta aaagtgttgt ttttctaatt     1740

tataactcct aggggttatt tctgtgccag acacattcca cctctccagt attgcaggac     1800

agaatatatg tgttaatgaa aatgaatggc tgtacatatt tttttctttc ttcagagtac     1860

tctgtacaat aaatgcagtt tataaaagtg ttagattgtt gttaaaaaaa aaaaaaaaaa     1920

a                                                                     1921


<210>  155
<211>  1435
<212>  DNA
<213>  Homo sapiens

<400>  155
ggcggggcct gcttctcctc agcttcaggc ggctgcgacg agccctcagg cgaacctctc       60

ggctttcccg cgcggcgccg cctcttgctg cgcctccgcc tcctcctctg ctccgccacc      120

ggcttcctcc tcctgagcag tcagcccgcg cgccggccgg ctccgttatg gcgacccgca      180

gccctggcgt cgtgattagt gatgatgaac caggttatga ccttgattta ttttgcatac      240

ctaatcatta tgctgaggat ttggaaaggg tgtttattcc tcatggacta attatggaca      300

ggactgaacg tcttgctcga gatgtgatga aggagatggg aggccatcac attgtagccc      360

tctgtgtgct caaggggggc tataaattct ttgctgacct gctggattac atcaaagcac      420

tgaatagaaa tagtgataga tccattccta tgactgtaga ttttatcaga ctgaagagct      480

attgtaatga ccagtcaaca ggggacataa aagtaattgg tggagatgat ctctcaactt      540

taactggaaa gaatgtcttg attgtggaag atataattga cactggcaaa acaatgcaga      600

ctttgctttc cttggtcagg cagtataatc caaagatggt caaggtcgca agcttgctgg      660

tgaaaaggac cccacgaagt gttggatata agccagactt tgttggattt gaaattccag      720

acaagtttgt tgtaggatat gcccttgact ataatgaata cttcagggat ttgaatcatg      780

tttgtgtcat tagtgaaact ggaaaagcaa aatacaaagc ctaagatgag agttcaagtt      840

gagtttggaa acatctggag tcctattgac atcgccagta aaattatcaa tgttctagtt      900

ctgtggccat ctgcttagta gagctttttg catgtatctt ctaagaattt tatctgtttt      960

gtactttaga aatgtcagtt gctgcattcc taaactgttt atttgcacta tgagcctata     1020

gactatcagt tccctttggg cggattgttg tttaacttgt aaatgaaaaa attctcttaa     1080

accacagcac tattgagtga aacattgaac tcatatctgt aagaaataaa gagaagatat     1140

attagttttt taattggtat tttaattttt atatatgcag gaaagaatag aagtgattga     1200

atattgttaa ttataccacc gtgtgttaga aaagtaagaa gcagtcaatt ttcacatcaa     1260

agacagcatc taagaagttt tgttctgtcc tggaattatt ttagtagtgt ttcagtaatg     1320

ttgactgtat tttccaactt gttcaaatta ttaccagtga atctttgtca gcagttccct     1380

tttaaatgca aatcaataaa ttcccaaaaa tttaaaaaaa aaaaaaaaaa aaaaa          1435


<210>  156
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  156
accgccgaga ccgcgtccgc cccgcgagca cagagcctcg cctttgccga tccgccgccc       60

gtccacaccc gccgccagct caccatggat gatgatatcg ccgcgctcgt cgtcgacaac      120

ggctccggca tgtgcaaggc cggcttcgcg ggcgacgatg ccccccgggc cgtcttcccc      180

tccatcgtgg ggcgccccag gcaccagggc gtgatggtgg gcatgggtca gaaggattcc      240

tatgtgggcg acgaggccca gagcaagaga ggcatcctca ccctgaagta ccccatcgag      300

cacggcatcg tcaccaactg ggacgacatg gagaaaatct ggcaccacac cttctacaat      360

gagctgcgtg tggctcccga ggagcacccc gtgctgctga ccgaggcccc cctgaacccc      420

aaggccaacc gcgagaagat gacccagatc atgtttgaga ccttcaacac cccagccatg      480

tacgttgcta tccaggctgt gctatccctg tacgcctctg gccgtaccac tggcatcgtg      540

atggactccg gtgacggggt cacccacact gtgcccatct acgaggggta tgccctcccc      600

catgccatcc tgcgtctgga cctggctggc cgggacctga ctgactacct catgaagatc      660

ctcaccgagc gcggctacag cttcaccacc acggccgagc gggaaatcgt gcgtgacatt      720

aaggagaagc tgtgctacgt cgccctggac ttcgagcaag agatggccac ggctgcttcc      780

agctcctccc tggagaagag ctacgagctg cctgacggcc aggtcatcac cattggcaat      840

gagcggttcc gctgccctga ggcactcttc cagccttcct tcctgggcat ggagtcctgt      900

ggcatccacg aaactacctt caactccatc atgaagtgtg acgtggacat ccgcaaagac      960

ctgtacgcca acacagtgct gtctggcggc accaccatgt accctggcat tgccgacagg     1020

atgcagaagg agatcactgc cctggcaccc agcacaatga agatcaagat cattgctcct     1080

cctgagcgca agtactccgt gtggatcggc ggctccatcc tggcctcgct gtccaccttc     1140

cagcagatgt ggatcagcaa gcaggagtat gacgagtccg gcccctccat cgtccaccgc     1200

aaatgcttct aggcggacta tgacttagtt gcgttacacc ctttcttgac aaaacctaac     1260

ttgcgcagaa aacaagatga gattggcatg gctttatttg ttttttttgt tttgttttgg     1320

tttttttttt ttttttggct tgactcagga tttaaaaact ggaacggtga aggtgacagc     1380

agtcggttgg agcgagcatc ccccaaagtt cacaatgtgg ccgaggactt tgattgcaca     1440

ttgttgtttt tttaatagtc attccaaata tgagatgcgt tgttacagga agtcccttgc     1500

catcctaaaa gccaccccac ttctctctaa ggagaatggc ccagtcctct cccaagtcca     1560

cacaggggag gtgatagcat tgctttcgtg taaattatgt aatgcaaaat ttttttaatc     1620

ttcgccttaa tactttttta ttttgtttta ttttgaatga tgagccttcg tgccccccct     1680

tccccctttt ttgtccccca acttgagatg tatgaaggct tttggtctcc ctgggagtgg     1740

gtggaggcag ccagggctta cctgtacact gacttgagac cagttgaata aaagtgcaca     1800

ccttaaaaat gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa             1852


<210>  157
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  157
gtctgacggg cgatggcgca gccaatagac aggagcgcta tccgcggttt ctgattggct       60

actttgttcg cattataaaa ggcacgcgcg ggcgcgaggc ccttctctcg ccaggcgtcc      120

tcgtggaagt gacatcgtct ttaaaccctg cgtggcaatc cctgacgcac cgccgtgatg      180

cccagggaag acagggcgac ctggaagtcc aactacttcc ttaagatcat ccaactattg      240

gatgattatc cgaaatgttt cattgtggga gcagacaatg tgggctccaa gcagatgcag      300

cagatccgca tgtcccttcg cgggaaggct gtggtgctga tgggcaagaa caccatgatg      360

cgcaaggcca tccgagggca cctggaaaac aacccagctc tggagaaact gctgcctcat      420

atccggggga atgtgggctt tgtgttcacc aaggaggacc tcactgagat cagggacatg      480

ttgctggcca ataaggtgcc agctgctgcc cgtgctggtg ccattgcccc atgtgaagtc      540

actgtgccag cccagaacac tggtctcggg cccgagaaga cctccttttt ccaggcttta      600

ggtatcacca ctaaaatctc caggggcacc attgaaatcc tgagtgatgt gcagctgatc      660

aagactggag acaaagtggg agccagcgaa gccacgctgc tgaacatgct caacatctcc      720

cccttctcct ttgggctggt catccagcag gtgttcgaca atggcagcat ctacaaccct      780

gaagtgcttg atatcacaga ggaaactctg cattctcgct tcctggaggg tgtccgcaat      840

gttgccagtg tctgtctgca gattggctac ccaactgttg catcagtacc ccattctatc      900

atcaacgggt acaaacgagt cctggccttg tctgtggaga cggattacac cttcccactt      960

gctgaaaagg tcaaggcctt cttggctgat ccatctgcct ttgtggctgc tgcccctgtg     1020

gctgctgcca ccacagctgc tcctgctgct gctgcagccc cagctaaggt tgaagccaag     1080

gaagagtcgg aggagtcgga cgaggatatg ggatttggtc tctttgacta atcaccaaaa     1140

agcaaccaac ttagccagtt ttatttgcaa aacaaggaaa taaaggctta cttctttaaa     1200

aagtaaaaaa aaaaaaaaaa aaaaaaaaa                                       1229


<210>  158
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  158
gtctgacggg cgatggcgca gccaatagac aggagcgcta tccgcggttt ctgattggct       60

actttgttcg cattataaaa ggcacgcgcg ggcgcgaggc ccttctctcg ccaggcgtcc      120

tcgtggaagt gacatcgtct ttaaaccctg cgtggcaatc cctgacgcac cgccgtgatg      180

cccagggaag acagggcgac ctggaagtcc aactacttcc ttaagatcat ccaactattg      240

gatgattatc cgaaatgttt cattgtggga gcagacaatg tgggctccaa gcagatgcag      300

cagatccgca tgtcccttcg cgggaaggct gtggtgctga tgggcaagaa caccatgatg      360

cgcaaggcca tccgagggca cctggaaaac aacccagctc tggagaaact gctgcctcat      420

atccggggga atgtgggctt tgtgttcacc aaggaggacc tcactgagat cagggacatg      480

ttgctggcca ataaggtgcc agctgctgcc cgtgctggtg ccattgcccc atgtgaagtc      540

actgtgccag cccagaacac tggtctcggg cccgagaaga cctccttttt ccaggcttta      600

ggtatcacca ctaaaatctc caggggcacc attgaaatcc tgagtgatgt gcagctgatc      660

aagactggag acaaagtggg agccagcgaa gccacgctgc tgaacatgct caacatctcc      720

cccttctcct ttgggctggt catccagcag gtgttcgaca atggcagcat ctacaaccct      780

gaagtgcttg atatcacaga ggaaactctg cattctcgct tcctggaggg tgtccgcaat      840

gttgccagtg tctgtctgca gattggctac ccaactgttg catcagtacc ccattctatc      900

atcaacgggt acaaacgagt cctggccttg tctgtggaga cggattacac cttcccactt      960

gctgaaaagg tcaaggcctt cttggctgat ccatctgcct ttgtggctgc tgcccctgtg     1020

gctgctgcca ccacagctgc tcctgctgct gctgcagccc cagctaaggt tgaagccaag     1080

gaagagtcgg aggagtcgga cgaggatatg ggatttggtc tctttgacta atcaccaaaa     1140

agcaaccaac ttagccagtt ttatttgcaa aacaaggaaa taaaggctta cttctttaaa     1200

aagtaaaaaa aaaaaaaaaa aaaaaaaaa                                       1229


<210>  159
<211>  6738
<212>  DNA
<213>  Homo sapiens

<400>  159
gagagcgcgg ccgggacggt tggagaagaa ggcggctccc ggaaggggga gagacaaact       60

gccgtaacct ctgccgttca ggaacccggt tacttattta ttcgttaccc tttttcttct      120

tcctccccca aaaacctttt ccttttccct tctttttttt tcctttttgg gagctgaaaa      180

atttccggta agggaaagaa gggctccttt cgctccttat ttccccgcct ccttccctcc      240

cccaccttcc cctcctccgg ctttttcctc ccaactcggg gaggtccttc ccggtggccg      300

ccctgacgag gtctgagcac ctaggcggag gcggcgcagg ctttttgtag tgaggtttgc      360

gcctgcgcag cgcgcctgcc tccgccatgc acgggggtgg ccccccctcg ggggacagcg      420

catgcccgct gcgcaccatc aagagagtcc agttcggagt cctgagtccg gatgaactga      480

agcgaatgtc tgtgacggag ggtggcatca aatacccaga gacgactgag ggaggccgcc      540

ccaagcttgg ggggctgatg gacccgaggc agggggtgat tgagcggact ggccgctgcc      600

aaacatgtgc aggaaacatg acagagtgtc ctggccactt tggccacatt gaactggcca      660

agcctgtgtt tcacgtgggc ttcctggtga agacaatgaa agttttgcgc tgtgtctgct      720

tcttctgctc caaactgctt gtggactcta acaacccaaa gatcaaggat atcctggcta      780

agtccaaggg acagcccaag aagcggctca cacatgtcta cgacctttgc aagggcaaaa      840

acatatgcga gggtggggag gagatggaca acaagttcgg tgtggaacaa cctgagggtg      900

acgaggatct gaccaaagaa aagggccatg gtggctgtgg gcggtaccag cccaggatcc      960

ggcgttctgg cctagagctg tatgcggaat ggaagcacgt taatgaggac tctcaggaga     1020

agaagatcct gctgagtcca gagcgagtgc atgagatctt caaacgcatc tcagatgagg     1080

agtgttttgt gctgggcatg gagccccgct atgcacggcc agagtggatg attgtcacag     1140

tgctgcctgt gcccccgctc tccgtgcggc ctgctgttgt gatgcagggc tctgcccgta     1200

accaggatga cctgactcac aaactggctg acatcgtgaa gatcaacaat cagctgcggc     1260

gcaatgagca gaacggcgca gcggcccatg tcattgcaga ggatgtgaag ctcctccagt     1320

tccatgtggc caccatggtg gacaatgagc tgcctggctt gccccgtgcc atgcagaagt     1380

ctgggcgtcc cctcaagtcc ctgaagcagc ggttgaaggg caaggaaggc cgggtgcgag     1440

ggaacctgat gggcaaaaga gtggacttct cggcccgtac tgtcatcacc cccgacccca     1500

acctctccat tgaccaggtt ggcgtgcccc gctccattgc tgccaacatg acctttgcgg     1560

agattgtcac ccccttcaac attgacagac ttcaagaact agtgcgcagg gggaacagcc     1620

agtacccagg cgccaagtac atcatccgag acaatggtga tcgcattgac ttgcgtttcc     1680

accccaagcc cagtgacctt cacctgcaga ccggctataa ggtggaacgg cacatgtgtg     1740

atggggacat tgttatcttc aaccggcagc caactctgca caaaatgtcc atgatggggc     1800

atcgggtccg cattctccca tggtctacct ttcgcttgaa tcttagtgtg acaactccgt     1860

acaatgcaga ctttgacggg gatgagatga acttgcacct gccacagtct ctggagacgc     1920

gagcagagat ccaggagctg gccatggttc ctcgcatgat tgtcaccccc cagagcaatc     1980

ggcctgtcat gggtattgtg caggacacac tcacagcagt gcgcaaattc accaagagag     2040

acgtcttcct ggagcggggt gaagtgatga acctcctgat gttcctgtcg acgtgggatg     2100

ggaaggtccc acagccggcc atcctaaagc cccggcccct gtggacaggc aagcaaatct     2160

tctccctcat catacctggt cacatcaatt gtatccgtac ccacagcacc catcccgatg     2220

atgaagacag tggcccttac aagcacatct ctcctgggga caccaaggtg gtggtggaga     2280

atggggagct gatcatgggc atcctgtgta agaagtctct gggcacgtca gctggctccc     2340

tggtccacat ctcctaccta gagatgggtc atgacatcac tcgcctcttc tactccaaca     2400

ttcagactgt cattaacaac tggctcctca tcgagggtca tactattggc attggggact     2460

ccattgctga ttctaagact taccaggaca ttcagaacac tattaagaag gccaagcagg     2520

acgtaataga ggtcatcgag aaggcacaca acaatgagct ggagcccacc ccagggaaca     2580

ctctgcggca gacgtttgag aatcaggtga accgcattct taacgatgcc cgagacaaga     2640

ctggctcctc tgctcagaaa tccctgtctg aatacaacaa cttcaagtct atggtcgtgt     2700

ccggagctaa aggttccaag attaacatct cccaggtcat tgctgtcgtt ggacagcaga     2760

acgtcgaggg caagcggatt ccatttggct tcaagcaccg gactctgcct cacttcatca     2820

aggatgacta cgggcctgag agccgtggct ttgtggagaa ctcctaccta gccggcctca     2880

cacccactga gttctttttc cacgccatgg ggggtcgtga ggggctcatt gacacggctg     2940

tcaagactgc tgagactgga tacatccagc ggcggctgat caagtccatg gagtcagtga     3000

tggtgaagta cgacgcgact gtgcggaact ccatcaacca ggtggtgcag ctgcgctacg     3060

gcgaagacgg cctggcaggc gagagcgttg agttccagaa cctggctacg cttaagcctt     3120

ccaacaaggc ttttgagaag aagttccgct ttgattatac caatgagagg gccctgcggc     3180

gcactctgca ggaggacctg gtgaaggacg tgctgagcaa cgcacacatc cagaacgagt     3240

tggagcggga atttgagcgg atgcgggagg atcgggaggt gctcagggtc atcttcccaa     3300

ctggagacag caaggtcgtc ctcccctgta acctgctgcg gatgatctgg aatgctcaga     3360

aaatcttcca catcaaccca cgccttccct ccgacctgca ccccatcaaa gtggtggagg     3420

gagtcaagga attgagcaag aagctggtga ttgtgaatgg ggatgaccca ctaagtcgac     3480

aggcccagga aaatgccacg ctgctcttca acatccacct gcggtccacg ttgtgttccc     3540

gccgcatggc agaggagttt cggctcagtg gggaggcctt cgactggctg cttggggaga     3600

ttgagtccaa gttcaaccaa gccattgcgc atcccgggga aatggtgggg gctctggctg     3660

cgcagtccct tggagaacct gccacccaga tgaccttgaa taccttccac tatgctggtg     3720

tgtctgccaa gaatgtgacg ctgggtgtgc cccgacttaa ggagctcatc aacatttcca     3780

agaagccaaa gactccttcg cttactgtct tcctgttggg ccagtccgct cgagatgctg     3840

agagagccaa ggatattctg tgccgtctgg agcatacaac gttgaggaag gtgactgcca     3900

acacagccat ctactatgac cccaaccccc agagcacggt ggtggcagag gatcaggaat     3960

gggtgaatgt ctactatgaa atgcctgact ttgatgtggc ccgaatctcc ccctggctgt     4020

tgcgggtgga gctggatcgg aagcacatga ctgaccggaa gctcaccatg gagcagattg     4080

ctgaaaagat caatgctggt tttggtgacg acttgaactg catctttaat gatgacaatg     4140

cagagaagct ggtgctccgt attcgcatca tgaacagcga tgagaacaag atgcaagagg     4200

aggaagaggt ggtggacaag atggatgatg atgtcttcct gcgctgcatc gagtccaaca     4260

tgctgacaga tatgaccctg cagggcatcg agcagatcag caaggtgtac atgcacttgc     4320

cacagacaga caacaagaag aagatcatca tcacggagga tggggaattc aaggccctgc     4380

aggagtggat cctggagacg gacggcgtga gcttgatgcg ggtgctgagt gagaaggacg     4440

tggaccccgt acgcaccacg tccaatgaca ttgtggagat cttcacggtg ctgggcattg     4500

aagccgtgcg gaaggccctg gagcgggagc tgtaccacgt catctccttt gatggctcct     4560

atgtcaatta ccgacacttg gctctcttgt gtgataccat gacctgtcgt ggccacttga     4620

tggccatcac ccgacacgga gtcaaccgcc aggacacagg accactcatg aagtgttcct     4680

ttgaggaaac ggtggacgtg cttatggaag cagccgcaca cggtgagagt gaccccatga     4740

agggggtctc tgagaatatc atgctgggcc agctggctcc ggccggcact ggctgctttg     4800

acctcctgct tgatgcagag aagtgcaagt atggcatgga gatccccacc aatatccccg     4860

gcctgggggc tgctggaccc accggcatgt tctttggttc agcacccagt cccatgggtg     4920

gaatctctcc tgccatgaca ccttggaacc agggtgcaac ccctgcctat ggcgcctggt     4980

cccccagtgt tgggagtgga atgaccccag gggcagccgg cttctctccc agtgctgcgt     5040

cagatgccag cggcttcagc ccaggttact cccctgcctg gtctcccaca ccgggctccc     5100

cggggtcccc aggtccctca agcccctaca tcccttcacc aggtggtgcc atgtctccca     5160

gctactcgcc aacgtcacct gcctacgagc cccgctctcc tgggggctac acaccccaga     5220

gtccctctta ttcccccact tcaccctcct actcccctac ctctccatcc tattctccaa     5280

ccagtcccaa ctatagtccc acatcaccca gctattcgcc aacgtcaccc agctactcac     5340

cgacctctcc cagctactca cccacctctc ccagctactc gcccacctct cccagctact     5400

cgcccacctc tcccagctac tcacccactt cccctagcta ctcgcccact tcccctagct     5460

actcgccaac gtctcccagc tactcgccga catctcccag ctactcgcca acttcaccca     5520

gctattctcc cacttctccc agctactcac ctacctctcc aagctattca cccacctccc     5580

ccagctactc acccacttcc ccaagttact cacccaccag cccgaactat tctccaacca     5640

gtcccaatta caccccaaca tcacccagct acagcccgac atcacccagc tattcaccta     5700

ctagtcccaa ctacacacct accagcccta actacagccc aacctctcca agctactctc     5760

caacatcacc cagctattcc ccgacctcac caagttactc cccttccagc ccacgataca     5820

caccacagtc tccaacctat accccaagct cacccagcta cagccccagc tcgcccagct     5880

acagcccaac ctcacccaag tacaccccaa ccagtccttc ttacagtccc agctccccag     5940

agtatacccc aacctctccc aagtactcac ctaccagtcc caaatattca cccacctctc     6000

ccaagtactc gcctaccagt cccacctatt cacccaccac cccaaaatac tccccaacat     6060

ctcctactta ttccccaacc tctccagtct acaccccaac ctctcccaag tactcaccta     6120

ctagccccac ttactcgccc acttccccca agtactcgcc caccagcccc acctactcgc     6180

ccacctcccc caaaggctca acctactctc ccacttcccc tggttactcg cccaccagcc     6240

ccacctacag tctcacaagc ccggctatca gcccggatga cagtgacgag gagaactgag     6300

ggcacgtggg gtgcggcagc gggctagggc ccagggcagc ttgcccgtgc tgctgtgcag     6360

ttcttgcctc cctcacgggg cgtcaccccc agcccagctc cgttgtacat aaatgccttg     6420

tggcagagct cccggtgaac ttctggatcc cgtttctgat gcagactctt gtcttgttct     6480

ccacttgtgc tgttagaact cactggccca gtggtgttct cactcctacc ccacccaccc     6540

cctgcctgtc cccaaattga agatccttcc ttgcctgtgg cttgatgcgg ggcgggtaaa     6600

gggtatttta acttaggggt agttcctgct gtgagtggtt acagctgatc ctcgggaaga     6660

acaaagctaa agctgccttt tgtctgttat tttatttttt tgaagtttaa ataaagttta     6720

ctaattttga ccaaaagt                                                   6738


<210>  160
<211>  987
<212>  DNA
<213>  Homo sapiens

<400>  160
aatataagtg gaggcgtcgc gctggcgggc attcctgaag ctgacagcat tcgggccgag       60

atgtctcgct ccgtggcctt agctgtgctc gcgctactct ctctttctgg cctggaggct      120

atccagcgta ctccaaagat tcaggtttac tcacgtcatc cagcagagaa tggaaagtca      180

aatttcctga attgctatgt gtctgggttt catccatccg acattgaagt tgacttactg      240

aagaatggag agagaattga aaaagtggag cattcagact tgtctttcag caaggactgg      300

tctttctatc tcttgtacta cactgaattc acccccactg aaaaagatga gtatgcctgc      360

cgtgtgaacc atgtgacttt gtcacagccc aagatagtta agtgggatcg agacatgtaa      420

gcagcatcat ggaggtttga agatgccgca tttggattgg atgaattcca aattctgctt      480

gcttgctttt taatattgat atgcttatac acttacactt tatgcacaaa atgtagggtt      540

ataataatgt taacatggac atgatcttct ttataattct actttgagtg ctgtctccat      600

gtttgatgta tctgagcagg ttgctccaca ggtagctcta ggagggctgg caacttagag      660

gtggggagca gagaattctc ttatccaaca tcaacatctt ggtcagattt gaactcttca      720

atctcttgca ctcaaagctt gttaagatag ttaagcgtgc ataagttaac ttccaattta      780

catactctgc ttagaatttg ggggaaaatt tagaaatata attgacagga ttattggaaa      840

tttgttataa tgaatgaaac attttgtcat ataagattca tatttacttc ttatacattt      900

gataaagtaa ggcatggttg tggttaatct ggtttatttt tgttccacaa gttaaataaa      960

tcataaaact tgatgtgtta tctctta                                          987


<210>  161
<211>  5416
<212>  DNA
<213>  Homo sapiens

<400>  161
agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc agagagagaa       60

gatcgggggg ctgaaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg      120

ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga      180

aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag      240

ggtcgcaagc gcagccacaa ccagctgcaa atcaggctct tgcagctggg actcactcca      300

gccctgtccc aggatctata ggagttgcag gccgttccca ggacgacgct atggtggact      360

acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtgga ggaggcggct      420

ataataatag caaacatcga tggcctactg gggataacat tcatgcagaa catcaggtgc      480

gttccatgga tgaactgaat catgattttc aagcacttgc tctggaggga agagcgatgg      540

gagagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac      600

caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt      660

cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg      720

aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg      780

agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa      840

gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt acgtttgatg      900

gagataagct aggagatttg aaggaggagg gtgatgtgat ggacaagacc aatggtttac      960

cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc     1020

agaactctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag     1080

cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc     1140

agagtgtccc cttggacccc atggaacatg tgggcatgga gcctcttcag tttgattatt     1200

caggcacgca ggtacctgtg gactcagcag cagcaactgt gggacttttt gactacaatt     1260

ctcaacaaca gctgttccaa agacctaatg cgcttgctgt ccagcagttg acagctgctc     1320

agcagcagca gtatgcactg gcagctgctc atcagccgca catcggttta gctcccgctg     1380

cgtttgtccc caatccatac atcatcagcg ctgctccccc agggacggac ccctacacag     1440

ctggattggc tgcagcagcg acactaggcc cagctgtggt ccctcaccag tattatggag     1500

ttactccctg gggagtctac cctgccagtc ttttccagca gcaagctgcc gctgccgctg     1560

cagcaactaa ttcagctaat caacagacca ccccacaggc tcagcaagga cagcagcagg     1620

ttctccgtgg aggagccagc caacgtcctt tgaccccaaa ccagaaccag cagggacagc     1680

aaacggatcc ccttgtggca gctgcagcag tgaattctgc ccttgcattt ggacaaggtc     1740

tggcagcagg catgccaggt tatccggtgt tggctcctgc tgcttactat gaccaaactg     1800

gtgcccttgt agtgaatgca ggcgcgagaa atggtcttgg agctcctgtt cgacttgtag     1860

ctcctgcccc agtcatcatt agttcctcag ctgcacaagc agctgttgca gcagccgcag     1920

cttcagcaaa tggagcagct ggtggtcttg ctggaacaac aaatggacca tttcgccctt     1980

taggaacaca gcagcctcag ccccagcccc agcagcagcc caataacaac ctggcatcca     2040

gttctttcta cggcaacaac tctctgaaca gcaattcaca gagcagctcc ctcttctccc     2100

agggctctgc ccagcctgcc aacacatcct tgggattcgg aagtagcagt tctctcggcg     2160

ccaccctggg atccgccctt ggagggtttg gaacagcagt tgcaaactcc aacactggca     2220

gtggctcccg ccgtgactcc ctgactggca gcagtgacct ttataagagg acatcgagca     2280

gcttgacccc cattggacac agtttttata acggccttag cttttcctcc tctcctggac     2340

ccgtgggcat gcctctccct agtcagggac caggacattc acagacacca cctccttccc     2400

tctcttcaca tggatcctct tcaagcttaa acctgggagg actcacgaat ggcagtggaa     2460

gatacatctc tgctgctcca ggcgctgaag ccaagtaccg cagtgcaagc agcgcctcca     2520

gcctcttcag cccgagcagc actcttttct cttcctctcg tttgcgatat ggaatgtctg     2580

atgtcatgcc ttctggcagg agcaggcttt tggaagattt tcgaaacaac cggtacccca     2640

atttacaact gcgggagatt gctggacata taatggaatt ttcccaagac cagcatgggt     2700

ccagattcat tcagctgaaa ctggagcgtg ccacaccagc tgagcgccag cttgtcttca     2760

atgaaatcct ccaggctgcc taccaactca tggtggatgt gtttggtaat tacgtcattc     2820

agaagttctt tgaatttggc agtcttgaac agaagctggc tttggcagaa cggattcgag     2880

gccacgtcct gtcattggca ctacagatgt atggctgccg tgttatccag aaagctcttg     2940

agtttattcc ttcagaccag caggtaatta atgagatggt tcgggaacta gatggccatg     3000

tcttgaagtg tgtgaaagat cagaatggca atcacgtggt tcagaaatgc attgaatgtg     3060

tacagcccca gtctttgcaa tttatcatcg atgcgtttaa gggacaggta tttgccttat     3120

ccacacatcc ttatggctgc cgagtgattc agagaatcct ggagcactgt ctccctgacc     3180

agacactccc tattttagag gagcttcacc agcacacaga gcagcttgta caggatcaat     3240

atggaaatta tgtaatccaa catgtactgg agcacggtcg tcctgaggat aaaagcaaaa     3300

ttgtagcaga aatccgaggc aatgtacttg tattgagtca gcacaaattt gcaagcaatg     3360

ttgtggagaa gtgtgttact cacgcctcac gtacggagcg cgctgtgctc atcgatgagg     3420

tgtgcaccat gaacgacggt ccccacagtg ccttatacac catgatgaag gaccagtatg     3480

ccaactacgt ggtccagaag atgattgacg tggcggagcc aggccagcgg aagatcgtca     3540

tgcataagat ccggccccac atcgcaactc ttcgtaagta cacctatggc aagcacattc     3600

tggccaagct ggagaagtac tacatgaaga acggtgttga cttagggccc atctgtggcc     3660

cccctaatgg tatcatctga ggcagtgtca cccgctgttc cctcattccc gctgacctca     3720

ctggcccact ggcaaatcca accagcaacc agaaatgttc tagtgtagag tctgagacgg     3780

gcaagtggtt gctccaggat tactccctcc tccaaaaaag gaatcaaatc cacgagtgga     3840

aaagcctttg taaatttaat tttattacac ataacatgta ctattttttt taattgacta     3900

attgccctgc tgttttactg gtgtatagga tacttgtaca taggtaacca atgtacatgg     3960

gaggccacat attttgttca ctgttgtatc tatatttcac atgtggaaac tttcagggtg     4020

gttggtttaa caaaaaaaaa aagctttaaa aaaaaaagaa aaaaaggaaa aggtttttag     4080

ctcatttgcc tggccggcaa gttttgcaaa tagctcttcc ccacctcctc attttagtaa     4140

aaaacaaaca aaaacaaaaa aacctgagaa gtttgaattg tagttaaatg accccaaact     4200

ggcatttaac actgtttata aaaaatatat atatatatat atatatatat aatgaaaaag     4260

gtttcagagt tgctaaagct tcagtttgtg acattaagtt tatgaaattc taaaaaatgc     4320

cttttttgga gactatatta tgctgaagaa ggctgttcgt gaggaggaga tgcgagcacc     4380

cagaacgtct tttgaggctg ggcgggtgtg attgtttact gcctactgga tttttttcta     4440

ttaacattga aaggtaaaat ctgattattt agcatgagaa aaaaaaatcc aactctgctt     4500

ttggtcttgc ttctataaat atatagtgta tacttggtgt agactttgca tatatacaaa     4560

tttgtagtat tttcttgttt tgatgtctaa tctgtatcta taatgtaccc tagtagtcga     4620

acatactttt gattgtacaa ttgtacattt gtatacctgt aatgtaaatg tggagaagtt     4680

tgaatcaaca taaacacgtt ttttggtaag aaaagagaat tagccagccc tgtgcattca     4740

gtgtatattc tcacctttta tggtcgtagc atatagtgtt gtatattgta aattgtaatt     4800

tcaaccagaa gtaaattttt ttcttttgaa ggaataaatg ttctttatac agcctagtta     4860

atgtttaaaa agaaaaaaat agcttggttt tatttgtcat ctagtctcaa gtatagcgag     4920

attctttcta aatgttattc aagattgagt tctcactagt gtttttttaa tcctaaaaaa     4980

gtaatgtttt gattttgtga cagtcaaaag gacgtgcaaa agtctagcct tgcccgagct     5040

ttccttacaa tcagagcccc tctcaccttg taaagtgtga atcgcccttc ccttttgtac     5100

agaagatgaa ctgtattttg cattttgtct acttgtaagt gaatgtaaca tactgtcaat     5160

tttccttgtt tgaatataga attgtaacac tacacggtgt acatttccag agccttgtgt     5220

atatttccaa tgaacttttt tgcaagcaca cttgtaacca tatgtgtata attaacaaac     5280

ctgtgtatgc ttatgcctgg gcaactattt tttgtaactc ttgtgtagat tgtctctaaa     5340

caatgtgtga tctttatttt gaaaaataca gaactttgga atctgaaaaa aaaaaaaaaa     5400

aaaaaaaaaa aaaaaa                                                     5416


<210>  162
<211>  5410
<212>  DNA
<213>  Homo sapiens

<400>  162
agtgggccgc catgttgtcg gagtgaaagg taagggggag cgagagcgcc agagagagaa       60

gatcgggggg ctgaaatcca tcttcatcct accgctccgc ccgtgttggt ggaatgagcg      120

ttgcatgtgt cttgaagaga aaagcagtgc tttggcagga ctctttcagc ccccacctga      180

aacatcaccc tcaagaacca gctaatccca acatgcctgt tgttttgaca tctggaacag      240

ggtcgcaagc gcagccacaa ccagctgcaa atcaggctct tgcagctggg actcactcca      300

gccctgtccc aggatctata ggagttgcag gccgttccca ggacgacgct atggtggact      360

acttctttca gaggcagcat ggtgagcagc ttgggggagg aggaagtgga ggaggcggct      420

ataataatag caaacatcga tggcctactg gggataacat tcatgcagaa catcaggtgc      480

gttccatgga tgaactgaat catgattttc aagcacttgc tctggaggga agagcgatgg      540

gagagcagct cttgccaggt aaaaagtttt gggaaacaga tgaatccagc aaagatggac      600

caaaaggaat attcctgggt gatcaatggc gagacagtgc ctggggaaca tcagatcatt      660

cagtttccca gccaatcatg gtgcagagaa gacctggtca gagtttccat gtgaacagtg      720

aggtcaattc tgtactgtcc ccacgatcgg agagtggggg actaggcgtt agcatggtgg      780

agtatgtgtt gagctcatcc ccgggcgatt cctgtctaag aaaaggagga tttggcccaa      840

gggatgcaga cagtgatgaa aacgacaaag gtgaaaagaa gaacaagggt acgtttgatg      900

gagataagct aggagatttg aaggaggagg gtgatgtgat ggacaagacc aatggtttac      960

cagtgcagaa tgggattgat gcagacgtca aagattttag ccgtacccct ggtaattgcc     1020

agaactctgc taatgaagtg gatcttctgg gtccaaacca gaatggttct gagggcttag     1080

cccagctgac cagcaccaat ggtgccaagc ctgtggagga tttctccaac atggagtccc     1140

agagtgtccc cttggacccc atggaacatg tgggcatgga gcctcttcag tttgattatt     1200

caggcacgca ggtacctgtg gactcagcag cagcaactgt gggacttttt gactacaatt     1260

ctcaacaaca gctgttccaa agacctaatg cgcttgctgt ccagcagttg acagctgctc     1320

agcagcagca gtatgcactg gcagctgctc atcagccgca catcggttta gctcccgctg     1380

cgtttgtccc caatccatac atcatcagcg ctgctccccc agggacggac ccctacacag     1440

ctggattggc tgcagcagcg acactaggcc cagctgtggt ccctcaccag tattatggag     1500

ttactccctg gggagtctac cctgccagtc ttttccagca gcaagctgcc gctgccgctg     1560

cagcaactaa ttcagctaat caacagacca ccccacaggc tcagcaagga cagcagcagg     1620

ttctccgtgg aggagccagc caacgtcctt tgaccccaaa ccagaaccag cagggacagc     1680

aaacggatcc ccttgtggca gctgcagcag tgaattctgc ccttgcattt ggacaaggtc     1740

tggcagcagg catgccaggt tatccggtgt tggctcctgc tgcttactat gaccaaactg     1800

gtgcccttgt agtgaatgca ggcgcgagaa atggtcttgg agctcctgtt cgacttgtag     1860

ctcctgcccc agtcatcatt agttcctcag ctgcacaagc agctgttgca gcagccgcag     1920

cttcagcaaa tggagcagct ggtggtcttg ctggaacaac aaatggacca tttcgccctt     1980

taggaacaca gcagcctcag ccccagcccc agcagcagcc caataacaac ctggcatcca     2040

gttctttcta cggcaacaac tctctgaaca gcaattcaca gagcagctcc ctcttctccc     2100

agggctctgc ccagcctgcc aacacatcct tgggattcgg aagtagcagt tctctcggcg     2160

ccaccctggg atccgccctt ggagggtttg gaacagcagt tgcaaactcc aacactggca     2220

gtggctcccg ccgtgactcc ctgactggca gcagtgacct ttataagagg acatcgagca     2280

gcttgacccc cattggacac agtttttata acggccttag cttttcctcc tctcctggac     2340

ccgtgggcat gcctctccct agtcagggac caggacattc acagacacca cctccttccc     2400

tctcttcaca tggatcctct tcaagcttaa acctgggagg actcacgaat ggcagtggaa     2460

gatacatctc tgctgctcca ggcgctgaag ccaagtaccg cagtgcaagc agcgcctcca     2520

gcctcttcag cccgagcagc actcttttct cttcctctcg tttgcgatat ggaatgtctg     2580

atgtcatgcc ttctggcagg agcaggcttt tggaagattt tcgaaacaac cggtacccca     2640

atttacaact gcgggagatt gctggacata taatggaatt ttcccaagac cagcatgggt     2700

ccagattcat tcagctgaaa ctggagcgtg ccacaccagc tgagcgccag cttgtcttca     2760

atgaaatcct ccaggctgcc taccaactca tggtggatgt gtttggtaat tacgtcattc     2820

agaagttctt tgaatttggc agtcttgaac agaagctggc tttggcagaa cggattcgag     2880

gccacgtcct gtcattggca ctacagatgt atggctgccg tgttatccag aaagctcttg     2940

agtttattcc ttcagaccag cagaatgaga tggttcggga actagatggc catgtcttga     3000

agtgtgtgaa agatcagaat ggcaatcacg tggttcagaa atgcattgaa tgtgtacagc     3060

cccagtcttt gcaatttatc atcgatgcgt ttaagggaca ggtatttgcc ttatccacac     3120

atccttatgg ctgccgagtg attcagagaa tcctggagca ctgtctccct gaccagacac     3180

tccctatttt agaggagctt caccagcaca cagagcagct tgtacaggat caatatggaa     3240

attatgtaat ccaacatgta ctggagcacg gtcgtcctga ggataaaagc aaaattgtag     3300

cagaaatccg aggcaatgta cttgtattga gtcagcacaa atttgcaagc aatgttgtgg     3360

agaagtgtgt tactcacgcc tcacgtacgg agcgcgctgt gctcatcgat gaggtgtgca     3420

ccatgaacga cggtccccac agtgccttat acaccatgat gaaggaccag tatgccaact     3480

acgtggtcca gaagatgatt gacgtggcgg agccaggcca gcggaagatc gtcatgcata     3540

agatccggcc ccacatcgca actcttcgta agtacaccta tggcaagcac attctggcca     3600

agctggagaa gtactacatg aagaacggtg ttgacttagg gcccatctgt ggccccccta     3660

atggtatcat ctgaggcagt gtcacccgct gttccctcat tcccgctgac ctcactggcc     3720

cactggcaaa tccaaccagc aaccagaaat gttctagtgt agagtctgag acgggcaagt     3780

ggttgctcca ggattactcc ctcctccaaa aaaggaatca aatccacgag tggaaaagcc     3840

tttgtaaatt taattttatt acacataaca tgtactattt tttttaattg actaattgcc     3900

ctgctgtttt actggtgtat aggatacttg tacataggta accaatgtac atgggaggcc     3960

acatattttg ttcactgttg tatctatatt tcacatgtgg aaactttcag ggtggttggt     4020

ttaacaaaaa aaaaaagctt taaaaaaaaa agaaaaaaag gaaaaggttt ttagctcatt     4080

tgcctggccg gcaagttttg caaatagctc ttccccacct cctcatttta gtaaaaaaca     4140

aacaaaaaca aaaaaacctg agaagtttga attgtagtta aatgacccca aactggcatt     4200

taacactgtt tataaaaaat atatatatat atatatatat atataatgaa aaaggtttca     4260

gagttgctaa agcttcagtt tgtgacatta agtttatgaa attctaaaaa atgccttttt     4320

tggagactat attatgctga agaaggctgt tcgtgaggag gagatgcgag cacccagaac     4380

gtcttttgag gctgggcggg tgtgattgtt tactgcctac tggatttttt tctattaaca     4440

ttgaaaggta aaatctgatt atttagcatg agaaaaaaaa atccaactct gcttttggtc     4500

ttgcttctat aaatatatag tgtatacttg gtgtagactt tgcatatata caaatttgta     4560

gtattttctt gttttgatgt ctaatctgta tctataatgt accctagtag tcgaacatac     4620

ttttgattgt acaattgtac atttgtatac ctgtaatgta aatgtggaga agtttgaatc     4680

aacataaaca cgttttttgg taagaaaaga gaattagcca gccctgtgca ttcagtgtat     4740

attctcacct tttatggtcg tagcatatag tgttgtatat tgtaaattgt aatttcaacc     4800

agaagtaaat ttttttcttt tgaaggaata aatgttcttt atacagccta gttaatgttt     4860

aaaaagaaaa aaatagcttg gttttatttg tcatctagtc tcaagtatag cgagattctt     4920

tctaaatgtt attcaagatt gagttctcac tagtgttttt ttaatcctaa aaaagtaatg     4980

ttttgatttt gtgacagtca aaaggacgtg caaaagtcta gccttgcccg agctttcctt     5040

acaatcagag cccctctcac cttgtaaagt gtgaatcgcc cttccctttt gtacagaaga     5100

tgaactgtat tttgcatttt gtctacttgt aagtgaatgt aacatactgt caattttcct     5160

tgtttgaata tagaattgta acactacacg gtgtacattt ccagagcctt gtgtatattt     5220

ccaatgaact tttttgcaag cacacttgta accatatgtg tataattaac aaacctgtgt     5280

atgcttatgc ctgggcaact attttttgta actcttgtgt agattgtctc taaacaatgt     5340

gtgatcttta ttttgaaaaa tacagaactt tggaatctga aaaaaaaaaa aaaaaaaaaa     5400

aaaaaaaaaa                                                            5410


<210>  163
<211>  1771
<212>  DNA
<213>  Homo sapiens

<400>  163
ggcggccagg ccgggcgcgg agtgggcgcg cggggccgga ggaggggcca gcgaccgcgg       60

caccgcctgt gcccgcccgc ccctccgcag ccgctactta agaggctcca gcgccggccc      120

cgccctagtg cgttacttac ctcgactctt agcttgtcgg ggacggtaac cgggacccgg      180

tgtctgctcc tgtcgccttc gcctcctaat ccctagccac tatgcgtgag tgcatctcca      240

tccacgttgg ccaggctggt gtccagattg gcaatgcctg ctgggagctc tactgcctgg      300

aacacggcat ccagcccgat ggccagatgc caagtgacaa gaccattggg ggaggagatg      360

actccttcaa caccttcttc agtgagacgg gcgctggcaa gcacgtgccc cgggctgtgt      420

ttgtagactt ggaacccaca gtcattgatg aagttcgcac tggcacctac cgccagctct      480

tccaccctga gcagctcatc acaggcaagg aagatgctgc caataactat gcccgagggc      540

actacaccat tggcaaggag atcattgacc ttgtgttgga ccgaattcgc aagctggctg      600

accagtgcac cggtcttcag ggcttcttgg ttttccacag ctttggtggg ggaactggtt      660

ctgggttcac ctccctgctc atggaacgtc tctcagttga ttatggcaag aagtccaagc      720

tggagttctc catttaccca gcaccccagg tttccacagc tgtagttgag ccctacaact      780

ccatcctcac cacccacacc accctggagc actctgattg tgccttcatg gtagacaatg      840

aggccatcta tgacatctgt cgtagaaacc tcgatatcga gcgcccaacc tacactaacc      900

ttaaccgcct tattagccag attgtgtcct ccatcactgc ttccctgaga tttgatggag      960

ccctgaatgt tgacctgaca gaattccaga ccaacctggt gccctacccc cgcatccact     1020

tccctctggc cacatatgcc cctgtcatct ctgctgagaa agcctaccat gaacagcttt     1080

ctgtagcaga gatcaccaat gcttgctttg agccagccaa ccagatggtg aaatgtgacc     1140

ctcgccatgg taaatacatg gcttgctgcc tgttgtaccg tggtgacgtg gttcccaaag     1200

atgtcaatgc tgccattgcc accatcaaaa ccaagcgcag catccagttt gtggattggt     1260

gccccactgg cttcaaggtt ggcatcaact accagcctcc cactgtggtg cctggtggag     1320

acctggccaa ggtacagaga gctgtgtgca tgctgagcaa caccacagcc attgctgagg     1380

cctgggctcg cctggaccac aagtttgacc tgatgtatgc caagcgtgcc tttgttcact     1440

ggtacgtggg tgaggggatg gaggaaggcg agttttcaga ggcccgtgaa gatatggctg     1500

cccttgagaa ggattatgag gaggttggtg tggattctgt tgaaggagag ggtgaggaag     1560

aaggagagga atactaatta tccattcctt ttggccctgc agcatgtcat gctcccagaa     1620

tttcagcttc agcttaactg acagacgtta aagctttctg gttagattgt tttcacttgg     1680

tgatcatgtc ttttccatgt gtacctgtaa tatttttcca tcatatctca aagtaaagtc     1740

attaacatca aaaaaaaaaa aaaaaaaaaa a                                    1771


<210>  164
<211>  2458
<212>  DNA
<213>  Homo sapiens

<400>  164
cagaagaagg cagcgcccaa ggcgcatgcg cagcggtcac tcccgctgta tattaaggcg       60

ccggcgatcg cggcctgagg ctgctcccgg acaagggcaa cgagcgtttc gtttggactt      120

ctcgacttga gtgcccgcct ccttcgccgc cgcctctgca gtcctcagcg cagttatgcc      180

cagttcttcc cgctgtgggg acacgaccac ggaggaatcc ttgcttcagg gactcgggac      240

cctgctggac cccttcctcg ggtttagggg atgtggggac caggagaaag tcaggatccc      300

taagagtctt ccctgcctgg atggatgagt ggcttcttct ccacctagat tctttccaca      360

ggagccagca tacttcctga acatggagag tgttgttcgc cgctgcccat tcttatcccg      420

agtcccccag gcctttctgc agaaagcagg caaatctctg ttgttctatg cccaaaactg      480

ccccaagatg atggaagttg gggccaagcc agcccctcgg gcattgtcca ctgcagcagt      540

acactaccaa cagatcaaag aaacccctcc ggccagtgag aaagacaaaa ctgctaaggc      600

caaggtccaa cagactcctg atggatccca gcagagtcca gatggcacac agcttccgtc      660

tggacacccc ttgcctgcca caagccaggg cactgcaagc aaatgccctt tcctggcagc      720

acagatgaat cagagaggca gcagtgtctt ctgcaaagcc agtcttgagc ttcaggagga      780

tgtgcaggaa atgaatgccg tgaggaaaga ggttgctgaa acctcagcag gccccagtgt      840

ggttagtgtg aaaaccgatg gaggggatcc cagtggactg ctgaagaact tccaggacat      900

catgcaaaag caaagaccag aaagagtgtc tcatcttctt caagataact tgccaaaatc      960

tgtttccact tttcagtatg atcgtttctt tgagaaaaaa attgatgaga aaaagaatga     1020

ccacacctat cgagttttta aaactgtgaa ccggcgagca cacatcttcc ccatggcaga     1080

tgactattca gactccctca tcaccaaaaa gcaagtgtca gtctggtgca gtaatgacta     1140

cctaggaatg agtcgccacc cacgggtgtg tggggcagtt atggacactt tgaaacaaca     1200

tggtgctggg gcaggtggta ctagaaatat ttctggaact agtaaattcc atgtggactt     1260

agagcgggag ctggcagacc tccatgggaa agatgccgca ctcttgtttt cctcgtgctt     1320

tgtggccaat gactcaaccc tcttcaccct ggctaagatg atgccaggct gtgagattta     1380

ctctgattct gggaaccatg cctccatgat ccaagggatt cgaaacagcc gagtgccaaa     1440

gtacatcttc cgccacaatg atgtcagcca cctcagagaa ctgctgcaaa gatctgaccc     1500

ctcagtcccc aagattgtgg catttgaaac tgtccattca atggatgggg cggtgtgccc     1560

actggaagag ctgtgtgatg tggcccatga gtttggagca atcaccttcg tggatgaggt     1620

ccacgcagtg gggctttatg gggctcgagg cggagggatt ggggatcggg atggagtcat     1680

gccaaaaatg gacatcattt ctggaacact tggcaaagcc tttggttgtg ttggagggta     1740

catcgccagc acgagttctc tgattgacac cgtacggtcc tatgctgctg gcttcatctt     1800

caccacctct ctgccaccca tgctgctggc tggagccctg gagtctgtgc ggatcctgaa     1860

gagcgctgag ggacgggtgc ttcgccgcca gcaccagcgc aacgtcaaac tcatgagaca     1920

gatgctaatg gatgccggcc tccctgttgt ccactgcccc agccacatca tccctgtgcg     1980

ggttgcagat gctgctaaaa acacagaagt ctgtgatgaa ctaatgagca gacataacat     2040

ctacgtgcaa gcaatcaatt accctacggt gccccgggga gaagagctcc tacggattgc     2100

ccccacccct caccacacac cccagatgat gaactacttc cttgagaatc tgctagtcac     2160

atggaagcaa gtggggctgg aactgaagcc tcattcctca gctgagtgca acttctgcag     2220

gaggccactg cattttgaag tgatgagtga aagagagaag tcctatttct caggcttgag     2280

caagttggta tctgctcagg cctgagcatg acctcaatta tttcacttaa ccccaggcca     2340

ttatcatatc cagatggtct tcagagttgt ctttatatgt gaattaagtt atattaaatt     2400

ttaatctata gtaaaaacat agtcctggaa ataaattctt gcttaaatgg tgaaaaaa       2458


<210>  165
<211>  2281
<212>  DNA
<213>  Homo sapiens

<400>  165
cagaagaagg cagcgcccaa ggcgcatgcg cagcggtcac tcccgctgta tattaaggcg       60

ccggcgatcg cggcctgagg ctgctcccgg acaagggcaa cgagcgtttc gtttggactt      120

ctcgacttga gtgcccgcct ccttcgccgc cgcctctgca gtcctcagcg cagtctttcc      180

acaggagcca gcatacttcc tgaacatgga gagtgttgtt cgccgctgcc cattcttatc      240

ccgagtcccc caggcctttc tgcagaaagc aggcaaatct ctgttgttct atgcccaaaa      300

ctgccccaag atgatggaag ttggggccaa gccagcccct cgggcattgt ccactgcagc      360

agtacactac caacagatca aagaaacccc tccggccagt gagaaagaca aaactgctaa      420

ggccaaggtc caacagactc ctgatggatc ccagcagagt ccagatggca cacagcttcc      480

gtctggacac cccttgcctg ccacaagcca gggcactgca agcaaatgcc ctttcctggc      540

agcacagatg aatcagagag gcagcagtgt cttctgcaaa gccagtcttg agcttcagga      600

ggatgtgcag gaaatgaatg ccgtgaggaa agaggttgct gaaacctcag caggccccag      660

tgtggttagt gtgaaaaccg atggagggga tcccagtgga ctgctgaaga acttccagga      720

catcatgcaa aagcaaagac cagaaagagt gtctcatctt cttcaagata acttgccaaa      780

atctgtttcc acttttcagt atgatcgttt ctttgagaaa aaaattgatg agaaaaagaa      840

tgaccacacc tatcgagttt ttaaaactgt gaaccggcga gcacacatct tccccatggc      900

agatgactat tcagactccc tcatcaccaa aaagcaagtg tcagtctggt gcagtaatga      960

ctacctagga atgagtcgcc acccacgggt gtgtggggca gttatggaca ctttgaaaca     1020

acatggtgct ggggcaggtg gtactagaaa tatttctgga actagtaaat tccatgtgga     1080

cttagagcgg gagctggcag acctccatgg gaaagatgcc gcactcttgt tttcctcgtg     1140

ctttgtggcc aatgactcaa ccctcttcac cctggctaag atgatgccag gctgtgagat     1200

ttactctgat tctgggaacc atgcctccat gatccaaggg attcgaaaca gccgagtgcc     1260

aaagtacatc ttccgccaca atgatgtcag ccacctcaga gaactgctgc aaagatctga     1320

cccctcagtc cccaagattg tggcatttga aactgtccat tcaatggatg gggcggtgtg     1380

cccactggaa gagctgtgtg atgtggccca tgagtttgga gcaatcacct tcgtggatga     1440

ggtccacgca gtggggcttt atggggctcg aggcggaggg attggggatc gggatggagt     1500

catgccaaaa atggacatca tttctggaac acttggcaaa gcctttggtt gtgttggagg     1560

gtacatcgcc agcacgagtt ctctgattga caccgtacgg tcctatgctg ctggcttcat     1620

cttcaccacc tctctgccac ccatgctgct ggctggagcc ctggagtctg tgcggatcct     1680

gaagagcgct gagggacggg tgcttcgccg ccagcaccag cgcaacgtca aactcatgag     1740

acagatgcta atggatgccg gcctccctgt tgtccactgc cccagccaca tcatccctgt     1800

gcgggttgca gatgctgcta aaaacacaga agtctgtgat gaactaatga gcagacataa     1860

catctacgtg caagcaatca attaccctac ggtgccccgg ggagaagagc tcctacggat     1920

tgcccccacc cctcaccaca caccccagat gatgaactac ttccttgaga atctgctagt     1980

cacatggaag caagtggggc tggaactgaa gcctcattcc tcagctgagt gcaacttctg     2040

caggaggcca ctgcattttg aagtgatgag tgaaagagag aagtcctatt tctcaggctt     2100

gagcaagttg gtatctgctc aggcctgagc atgacctcaa ttatttcact taaccccagg     2160

ccattatcat atccagatgg tcttcagagt tgtctttata tgtgaattaa gttatattaa     2220

attttaatct atagtaaaaa catagtcctg gaaataaatt cttgcttaaa tggtgaaaaa     2280

a                                                                     2281


<210>  166
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Asp Gln Asn Asn Ser Leu Pro Pro Tyr Ala Gln Gly Leu Ala Ser 
1               5                   10                  15      


Pro Gln Gly Ala Met Thr Pro Gly Ile Pro Ile Phe Ser Pro Met Met 
            20                  25                  30          


Pro Tyr Gly Thr Gly Leu Thr Pro Gln Pro Ile Gln Asn Thr Asn Ser 
        35                  40                  45              


Leu Ser Ile Leu Glu Glu Gln Gln Arg Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala 
                85                  90                  95      


Val Ala Ala Ala Ala Val Gln Gln Ser Thr Ser Gln Gln Ala Thr Gln 
            100                 105                 110         


Gly Thr Ser Gly Gln Ala Pro Gln Leu Phe His Ser Gln Thr Leu Thr 
        115                 120                 125             


Thr Ala Pro Leu Pro Gly Thr Thr Pro Leu Tyr Pro Ser Pro Met Thr 
    130                 135                 140                 


Pro Met Thr Pro Ile Thr Pro Ala Thr Pro Ala Ser Glu Ser Ser Gly 
145                 150                 155                 160 


Ile Val Pro Gln Leu Gln Asn Ile Val Ser Thr Val Asn Leu Gly Cys 
                165                 170                 175     


Lys Leu Asp Leu Lys Thr Ile Ala Leu Arg Ala Arg Asn Ala Glu Tyr 
            180                 185                 190         


Asn Pro Lys Arg Phe Ala Ala Val Ile Met Arg Ile Arg Glu Pro Arg 
        195                 200                 205             


Thr Thr Ala Leu Ile Phe Ser Ser Gly Lys Met Val Cys Thr Gly Ala 
    210                 215                 220                 


Lys Ser Glu Glu Gln Ser Arg Leu Ala Ala Arg Lys Tyr Ala Arg Val 
225                 230                 235                 240 


Val Gln Lys Leu Gly Phe Pro Ala Lys Phe Leu Asp Phe Lys Ile Gln 
                245                 250                 255     


Asn Met Val Gly Ser Cys Asp Val Lys Phe Pro Ile Arg Leu Glu Gly 
            260                 265                 270         


Leu Val Leu Thr His Gln Gln Phe Ser Ser Tyr Glu Pro Glu Leu Phe 
        275                 280                 285             


Pro Gly Leu Ile Tyr Arg Met Ile Lys Pro Arg Ile Val Leu Leu Ile 
    290                 295                 300                 


Phe Val Ser Gly Lys Val Val Leu Thr Gly Ala Lys Val Arg Ala Glu 
305                 310                 315                 320 


Ile Tyr Glu Ala Phe Glu Asn Ile Tyr Pro Ile Leu Lys Gly Phe Arg 
                325                 330                 335     


Lys Thr Thr 
            


<210>  167
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Ala Thr Arg Ser Pro Gly Val Val Ile Ser Asp Asp Glu Pro Gly 
1               5                   10                  15      


Tyr Asp Leu Asp Leu Phe Cys Ile Pro Asn His Tyr Ala Glu Asp Leu 
            20                  25                  30          


Glu Arg Val Phe Ile Pro His Gly Leu Ile Met Asp Arg Thr Glu Arg 
        35                  40                  45              


Leu Ala Arg Asp Val Met Lys Glu Met Gly Gly His His Ile Val Ala 
    50                  55                  60                  


Leu Cys Val Leu Lys Gly Gly Tyr Lys Phe Phe Ala Asp Leu Leu Asp 
65                  70                  75                  80  


Tyr Ile Lys Ala Leu Asn Arg Asn Ser Asp Arg Ser Ile Pro Met Thr 
                85                  90                  95      


Val Asp Phe Ile Arg Leu Lys Ser Tyr Cys Asn Asp Gln Ser Thr Gly 
            100                 105                 110         


Asp Ile Lys Val Ile Gly Gly Asp Asp Leu Ser Thr Leu Thr Gly Lys 
        115                 120                 125             


Asn Val Leu Ile Val Glu Asp Ile Ile Asp Thr Gly Lys Thr Met Gln 
    130                 135                 140                 


Thr Leu Leu Ser Leu Val Arg Gln Tyr Asn Pro Lys Met Val Lys Val 
145                 150                 155                 160 


Ala Ser Leu Leu Val Lys Arg Thr Pro Arg Ser Val Gly Tyr Lys Pro 
                165                 170                 175     


Asp Phe Val Gly Phe Glu Ile Pro Asp Lys Phe Val Val Gly Tyr Ala 
            180                 185                 190         


Leu Asp Tyr Asn Glu Tyr Phe Arg Asp Leu Asn His Val Cys Val Ile 
        195                 200                 205             


Ser Glu Thr Gly Lys Ala Lys Tyr Lys Ala 
    210                 215             


<210>  168
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  169
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
1               5                   10                  15      


Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
            20                  25                  30          


Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
        35                  40                  45              


Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
    50                  55                  60                  


Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
65                  70                  75                  80  


His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                85                  90                  95      


Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
            100                 105                 110         


Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
        115                 120                 125             


Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
    130                 135                 140                 


Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
145                 150                 155                 160 


Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                165                 170                 175     


Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
            180                 185                 190         


Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
        195                 200                 205             


Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
    210                 215                 220                 


Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
225                 230                 235                 240 


Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                245                 250                 255     


Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
            260                 265                 270         


Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
    290                 295                 300                 


Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
305                 310                 315         


<210>  170
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Pro Arg Glu Asp Arg Ala Thr Trp Lys Ser Asn Tyr Phe Leu Lys 
1               5                   10                  15      


Ile Ile Gln Leu Leu Asp Asp Tyr Pro Lys Cys Phe Ile Val Gly Ala 
            20                  25                  30          


Asp Asn Val Gly Ser Lys Gln Met Gln Gln Ile Arg Met Ser Leu Arg 
        35                  40                  45              


Gly Lys Ala Val Val Leu Met Gly Lys Asn Thr Met Met Arg Lys Ala 
    50                  55                  60                  


Ile Arg Gly His Leu Glu Asn Asn Pro Ala Leu Glu Lys Leu Leu Pro 
65                  70                  75                  80  


His Ile Arg Gly Asn Val Gly Phe Val Phe Thr Lys Glu Asp Leu Thr 
                85                  90                  95      


Glu Ile Arg Asp Met Leu Leu Ala Asn Lys Val Pro Ala Ala Ala Arg 
            100                 105                 110         


Ala Gly Ala Ile Ala Pro Cys Glu Val Thr Val Pro Ala Gln Asn Thr 
        115                 120                 125             


Gly Leu Gly Pro Glu Lys Thr Ser Phe Phe Gln Ala Leu Gly Ile Thr 
    130                 135                 140                 


Thr Lys Ile Ser Arg Gly Thr Ile Glu Ile Leu Ser Asp Val Gln Leu 
145                 150                 155                 160 


Ile Lys Thr Gly Asp Lys Val Gly Ala Ser Glu Ala Thr Leu Leu Asn 
                165                 170                 175     


Met Leu Asn Ile Ser Pro Phe Ser Phe Gly Leu Val Ile Gln Gln Val 
            180                 185                 190         


Phe Asp Asn Gly Ser Ile Tyr Asn Pro Glu Val Leu Asp Ile Thr Glu 
        195                 200                 205             


Glu Thr Leu His Ser Arg Phe Leu Glu Gly Val Arg Asn Val Ala Ser 
    210                 215                 220                 


Val Cys Leu Gln Ile Gly Tyr Pro Thr Val Ala Ser Val Pro His Ser 
225                 230                 235                 240 


Ile Ile Asn Gly Tyr Lys Arg Val Leu Ala Leu Ser Val Glu Thr Asp 
                245                 250                 255     


Tyr Thr Phe Pro Leu Ala Glu Lys Val Lys Ala Phe Leu Ala Asp Pro 
            260                 265                 270         


Ser Ala Phe Val Ala Ala Ala Pro Val Ala Ala Ala Thr Thr Ala Ala 
        275                 280                 285             


Pro Ala Ala Ala Ala Ala Pro Ala Lys Val Glu Ala Lys Glu Glu Ser 
    290                 295                 300                 


Glu Glu Ser Asp Glu Asp Met Gly Phe Gly Leu Phe Asp 
305                 310                 315         


<210>  171
<211>  1970
<212>  PRT
<213>  Homo sapiens

<400>  171

Met His Gly Gly Gly Pro Pro Ser Gly Asp Ser Ala Cys Pro Leu Arg 
1               5                   10                  15      


Thr Ile Lys Arg Val Gln Phe Gly Val Leu Ser Pro Asp Glu Leu Lys 
            20                  25                  30          


Arg Met Ser Val Thr Glu Gly Gly Ile Lys Tyr Pro Glu Thr Thr Glu 
        35                  40                  45              


Gly Gly Arg Pro Lys Leu Gly Gly Leu Met Asp Pro Arg Gln Gly Val 
    50                  55                  60                  


Ile Glu Arg Thr Gly Arg Cys Gln Thr Cys Ala Gly Asn Met Thr Glu 
65                  70                  75                  80  


Cys Pro Gly His Phe Gly His Ile Glu Leu Ala Lys Pro Val Phe His 
                85                  90                  95      


Val Gly Phe Leu Val Lys Thr Met Lys Val Leu Arg Cys Val Cys Phe 
            100                 105                 110         


Phe Cys Ser Lys Leu Leu Val Asp Ser Asn Asn Pro Lys Ile Lys Asp 
        115                 120                 125             


Ile Leu Ala Lys Ser Lys Gly Gln Pro Lys Lys Arg Leu Thr His Val 
    130                 135                 140                 


Tyr Asp Leu Cys Lys Gly Lys Asn Ile Cys Glu Gly Gly Glu Glu Met 
145                 150                 155                 160 


Asp Asn Lys Phe Gly Val Glu Gln Pro Glu Gly Asp Glu Asp Leu Thr 
                165                 170                 175     


Lys Glu Lys Gly His Gly Gly Cys Gly Arg Tyr Gln Pro Arg Ile Arg 
            180                 185                 190         


Arg Ser Gly Leu Glu Leu Tyr Ala Glu Trp Lys His Val Asn Glu Asp 
        195                 200                 205             


Ser Gln Glu Lys Lys Ile Leu Leu Ser Pro Glu Arg Val His Glu Ile 
    210                 215                 220                 


Phe Lys Arg Ile Ser Asp Glu Glu Cys Phe Val Leu Gly Met Glu Pro 
225                 230                 235                 240 


Arg Tyr Ala Arg Pro Glu Trp Met Ile Val Thr Val Leu Pro Val Pro 
                245                 250                 255     


Pro Leu Ser Val Arg Pro Ala Val Val Met Gln Gly Ser Ala Arg Asn 
            260                 265                 270         


Gln Asp Asp Leu Thr His Lys Leu Ala Asp Ile Val Lys Ile Asn Asn 
        275                 280                 285             


Gln Leu Arg Arg Asn Glu Gln Asn Gly Ala Ala Ala His Val Ile Ala 
    290                 295                 300                 


Glu Asp Val Lys Leu Leu Gln Phe His Val Ala Thr Met Val Asp Asn 
305                 310                 315                 320 


Glu Leu Pro Gly Leu Pro Arg Ala Met Gln Lys Ser Gly Arg Pro Leu 
                325                 330                 335     


Lys Ser Leu Lys Gln Arg Leu Lys Gly Lys Glu Gly Arg Val Arg Gly 
            340                 345                 350         


Asn Leu Met Gly Lys Arg Val Asp Phe Ser Ala Arg Thr Val Ile Thr 
        355                 360                 365             


Pro Asp Pro Asn Leu Ser Ile Asp Gln Val Gly Val Pro Arg Ser Ile 
    370                 375                 380                 


Ala Ala Asn Met Thr Phe Ala Glu Ile Val Thr Pro Phe Asn Ile Asp 
385                 390                 395                 400 


Arg Leu Gln Glu Leu Val Arg Arg Gly Asn Ser Gln Tyr Pro Gly Ala 
                405                 410                 415     


Lys Tyr Ile Ile Arg Asp Asn Gly Asp Arg Ile Asp Leu Arg Phe His 
            420                 425                 430         


Pro Lys Pro Ser Asp Leu His Leu Gln Thr Gly Tyr Lys Val Glu Arg 
        435                 440                 445             


His Met Cys Asp Gly Asp Ile Val Ile Phe Asn Arg Gln Pro Thr Leu 
    450                 455                 460                 


His Lys Met Ser Met Met Gly His Arg Val Arg Ile Leu Pro Trp Ser 
465                 470                 475                 480 


Thr Phe Arg Leu Asn Leu Ser Val Thr Thr Pro Tyr Asn Ala Asp Phe 
                485                 490                 495     


Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Ser Leu Glu Thr Arg 
            500                 505                 510         


Ala Glu Ile Gln Glu Leu Ala Met Val Pro Arg Met Ile Val Thr Pro 
        515                 520                 525             


Gln Ser Asn Arg Pro Val Met Gly Ile Val Gln Asp Thr Leu Thr Ala 
    530                 535                 540                 


Val Arg Lys Phe Thr Lys Arg Asp Val Phe Leu Glu Arg Gly Glu Val 
545                 550                 555                 560 


Met Asn Leu Leu Met Phe Leu Ser Thr Trp Asp Gly Lys Val Pro Gln 
                565                 570                 575     


Pro Ala Ile Leu Lys Pro Arg Pro Leu Trp Thr Gly Lys Gln Ile Phe 
            580                 585                 590         


Ser Leu Ile Ile Pro Gly His Ile Asn Cys Ile Arg Thr His Ser Thr 
        595                 600                 605             


His Pro Asp Asp Glu Asp Ser Gly Pro Tyr Lys His Ile Ser Pro Gly 
    610                 615                 620                 


Asp Thr Lys Val Val Val Glu Asn Gly Glu Leu Ile Met Gly Ile Leu 
625                 630                 635                 640 


Cys Lys Lys Ser Leu Gly Thr Ser Ala Gly Ser Leu Val His Ile Ser 
                645                 650                 655     


Tyr Leu Glu Met Gly His Asp Ile Thr Arg Leu Phe Tyr Ser Asn Ile 
            660                 665                 670         


Gln Thr Val Ile Asn Asn Trp Leu Leu Ile Glu Gly His Thr Ile Gly 
        675                 680                 685             


Ile Gly Asp Ser Ile Ala Asp Ser Lys Thr Tyr Gln Asp Ile Gln Asn 
    690                 695                 700                 


Thr Ile Lys Lys Ala Lys Gln Asp Val Ile Glu Val Ile Glu Lys Ala 
705                 710                 715                 720 


His Asn Asn Glu Leu Glu Pro Thr Pro Gly Asn Thr Leu Arg Gln Thr 
                725                 730                 735     


Phe Glu Asn Gln Val Asn Arg Ile Leu Asn Asp Ala Arg Asp Lys Thr 
            740                 745                 750         


Gly Ser Ser Ala Gln Lys Ser Leu Ser Glu Tyr Asn Asn Phe Lys Ser 
        755                 760                 765             


Met Val Val Ser Gly Ala Lys Gly Ser Lys Ile Asn Ile Ser Gln Val 
    770                 775                 780                 


Ile Ala Val Val Gly Gln Gln Asn Val Glu Gly Lys Arg Ile Pro Phe 
785                 790                 795                 800 


Gly Phe Lys His Arg Thr Leu Pro His Phe Ile Lys Asp Asp Tyr Gly 
                805                 810                 815     


Pro Glu Ser Arg Gly Phe Val Glu Asn Ser Tyr Leu Ala Gly Leu Thr 
            820                 825                 830         


Pro Thr Glu Phe Phe Phe His Ala Met Gly Gly Arg Glu Gly Leu Ile 
        835                 840                 845             


Asp Thr Ala Val Lys Thr Ala Glu Thr Gly Tyr Ile Gln Arg Arg Leu 
    850                 855                 860                 


Ile Lys Ser Met Glu Ser Val Met Val Lys Tyr Asp Ala Thr Val Arg 
865                 870                 875                 880 


Asn Ser Ile Asn Gln Val Val Gln Leu Arg Tyr Gly Glu Asp Gly Leu 
                885                 890                 895     


Ala Gly Glu Ser Val Glu Phe Gln Asn Leu Ala Thr Leu Lys Pro Ser 
            900                 905                 910         


Asn Lys Ala Phe Glu Lys Lys Phe Arg Phe Asp Tyr Thr Asn Glu Arg 
        915                 920                 925             


Ala Leu Arg Arg Thr Leu Gln Glu Asp Leu Val Lys Asp Val Leu Ser 
    930                 935                 940                 


Asn Ala His Ile Gln Asn Glu Leu Glu Arg Glu Phe Glu Arg Met Arg 
945                 950                 955                 960 


Glu Asp Arg Glu Val Leu Arg Val Ile Phe Pro Thr Gly Asp Ser Lys 
                965                 970                 975     


Val Val Leu Pro Cys Asn Leu Leu Arg Met Ile Trp Asn Ala Gln Lys 
            980                 985                 990         


Ile Phe His Ile Asn Pro Arg Leu  Pro Ser Asp Leu His  Pro Ile Lys 
        995                 1000                 1005             


Val Val  Glu Gly Val Lys Glu  Leu Ser Lys Lys Leu  Val Ile Val 
    1010                 1015                 1020             


Asn Gly  Asp Asp Pro Leu Ser  Arg Gln Ala Gln Glu  Asn Ala Thr 
    1025                 1030                 1035             


Leu Leu  Phe Asn Ile His Leu  Arg Ser Thr Leu Cys  Ser Arg Arg 
    1040                 1045                 1050             


Met Ala  Glu Glu Phe Arg Leu  Ser Gly Glu Ala Phe  Asp Trp Leu 
    1055                 1060                 1065             


Leu Gly  Glu Ile Glu Ser Lys  Phe Asn Gln Ala Ile  Ala His Pro 
    1070                 1075                 1080             


Gly Glu  Met Val Gly Ala Leu  Ala Ala Gln Ser Leu  Gly Glu Pro 
    1085                 1090                 1095             


Ala Thr  Gln Met Thr Leu Asn  Thr Phe His Tyr Ala  Gly Val Ser 
    1100                 1105                 1110             


Ala Lys  Asn Val Thr Leu Gly  Val Pro Arg Leu Lys  Glu Leu Ile 
    1115                 1120                 1125             


Asn Ile  Ser Lys Lys Pro Lys  Thr Pro Ser Leu Thr  Val Phe Leu 
    1130                 1135                 1140             


Leu Gly  Gln Ser Ala Arg Asp  Ala Glu Arg Ala Lys  Asp Ile Leu 
    1145                 1150                 1155             


Cys Arg  Leu Glu His Thr Thr  Leu Arg Lys Val Thr  Ala Asn Thr 
    1160                 1165                 1170             


Ala Ile  Tyr Tyr Asp Pro Asn  Pro Gln Ser Thr Val  Val Ala Glu 
    1175                 1180                 1185             


Asp Gln  Glu Trp Val Asn Val  Tyr Tyr Glu Met Pro  Asp Phe Asp 
    1190                 1195                 1200             


Val Ala  Arg Ile Ser Pro Trp  Leu Leu Arg Val Glu  Leu Asp Arg 
    1205                 1210                 1215             


Lys His  Met Thr Asp Arg Lys  Leu Thr Met Glu Gln  Ile Ala Glu 
    1220                 1225                 1230             


Lys Ile  Asn Ala Gly Phe Gly  Asp Asp Leu Asn Cys  Ile Phe Asn 
    1235                 1240                 1245             


Asp Asp  Asn Ala Glu Lys Leu  Val Leu Arg Ile Arg  Ile Met Asn 
    1250                 1255                 1260             


Ser Asp  Glu Asn Lys Met Gln  Glu Glu Glu Glu Val  Val Asp Lys 
    1265                 1270                 1275             


Met Asp  Asp Asp Val Phe Leu  Arg Cys Ile Glu Ser  Asn Met Leu 
    1280                 1285                 1290             


Thr Asp  Met Thr Leu Gln Gly  Ile Glu Gln Ile Ser  Lys Val Tyr 
    1295                 1300                 1305             


Met His  Leu Pro Gln Thr Asp  Asn Lys Lys Lys Ile  Ile Ile Thr 
    1310                 1315                 1320             


Glu Asp  Gly Glu Phe Lys Ala  Leu Gln Glu Trp Ile  Leu Glu Thr 
    1325                 1330                 1335             


Asp Gly  Val Ser Leu Met Arg  Val Leu Ser Glu Lys  Asp Val Asp 
    1340                 1345                 1350             


Pro Val  Arg Thr Thr Ser Asn  Asp Ile Val Glu Ile  Phe Thr Val 
    1355                 1360                 1365             


Leu Gly  Ile Glu Ala Val Arg  Lys Ala Leu Glu Arg  Glu Leu Tyr 
    1370                 1375                 1380             


His Val  Ile Ser Phe Asp Gly  Ser Tyr Val Asn Tyr  Arg His Leu 
    1385                 1390                 1395             


Ala Leu  Leu Cys Asp Thr Met  Thr Cys Arg Gly His  Leu Met Ala 
    1400                 1405                 1410             


Ile Thr  Arg His Gly Val Asn  Arg Gln Asp Thr Gly  Pro Leu Met 
    1415                 1420                 1425             


Lys Cys  Ser Phe Glu Glu Thr  Val Asp Val Leu Met  Glu Ala Ala 
    1430                 1435                 1440             


Ala His  Gly Glu Ser Asp Pro  Met Lys Gly Val Ser  Glu Asn Ile 
    1445                 1450                 1455             


Met Leu  Gly Gln Leu Ala Pro  Ala Gly Thr Gly Cys  Phe Asp Leu 
    1460                 1465                 1470             


Leu Leu  Asp Ala Glu Lys Cys  Lys Tyr Gly Met Glu  Ile Pro Thr 
    1475                 1480                 1485             


Asn Ile  Pro Gly Leu Gly Ala  Ala Gly Pro Thr Gly  Met Phe Phe 
    1490                 1495                 1500             


Gly Ser  Ala Pro Ser Pro Met  Gly Gly Ile Ser Pro  Ala Met Thr 
    1505                 1510                 1515             


Pro Trp  Asn Gln Gly Ala Thr  Pro Ala Tyr Gly Ala  Trp Ser Pro 
    1520                 1525                 1530             


Ser Val  Gly Ser Gly Met Thr  Pro Gly Ala Ala Gly  Phe Ser Pro 
    1535                 1540                 1545             


Ser Ala  Ala Ser Asp Ala Ser  Gly Phe Ser Pro Gly  Tyr Ser Pro 
    1550                 1555                 1560             


Ala Trp  Ser Pro Thr Pro Gly  Ser Pro Gly Ser Pro  Gly Pro Ser 
    1565                 1570                 1575             


Ser Pro  Tyr Ile Pro Ser Pro  Gly Gly Ala Met Ser  Pro Ser Tyr 
    1580                 1585                 1590             


Ser Pro  Thr Ser Pro Ala Tyr  Glu Pro Arg Ser Pro  Gly Gly Tyr 
    1595                 1600                 1605             


Thr Pro  Gln Ser Pro Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser 
    1610                 1615                 1620             


Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser Pro Asn  Tyr Ser Pro 
    1625                 1630                 1635             


Thr Ser  Pro Ser Tyr Ser Pro  Thr Ser Pro Ser Tyr  Ser Pro Thr 
    1640                 1645                 1650             


Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser 
    1655                 1660                 1665             


Pro Ser  Tyr Ser Pro Thr Ser  Pro Ser Tyr Ser Pro  Thr Ser Pro 
    1670                 1675                 1680             


Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser 
    1685                 1690                 1695             


Tyr Ser  Pro Thr Ser Pro Ser  Tyr Ser Pro Thr Ser  Pro Ser Tyr 
    1700                 1705                 1710             


Ser Pro  Thr Ser Pro Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser 
    1715                 1720                 1725             


Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser Pro Ser  Tyr Ser Pro 
    1730                 1735                 1740             


Thr Ser  Pro Asn Tyr Ser Pro  Thr Ser Pro Asn Tyr  Thr Pro Thr 
    1745                 1750                 1755             


Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser Tyr Ser  Pro Thr Ser 
    1760                 1765                 1770             


Pro Asn  Tyr Thr Pro Thr Ser  Pro Asn Tyr Ser Pro  Thr Ser Pro 
    1775                 1780                 1785             


Ser Tyr  Ser Pro Thr Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser 
    1790                 1795                 1800             


Tyr Ser  Pro Ser Ser Pro Arg  Tyr Thr Pro Gln Ser  Pro Thr Tyr 
    1805                 1810                 1815             


Thr Pro  Ser Ser Pro Ser Tyr  Ser Pro Ser Ser Pro  Ser Tyr Ser 
    1820                 1825                 1830             


Pro Thr  Ser Pro Lys Tyr Thr  Pro Thr Ser Pro Ser  Tyr Ser Pro 
    1835                 1840                 1845             


Ser Ser  Pro Glu Tyr Thr Pro  Thr Ser Pro Lys Tyr  Ser Pro Thr 
    1850                 1855                 1860             


Ser Pro  Lys Tyr Ser Pro Thr  Ser Pro Lys Tyr Ser  Pro Thr Ser 
    1865                 1870                 1875             


Pro Thr  Tyr Ser Pro Thr Thr  Pro Lys Tyr Ser Pro  Thr Ser Pro 
    1880                 1885                 1890             


Thr Tyr  Ser Pro Thr Ser Pro  Val Tyr Thr Pro Thr  Ser Pro Lys 
    1895                 1900                 1905             


Tyr Ser  Pro Thr Ser Pro Thr  Tyr Ser Pro Thr Ser  Pro Lys Tyr 
    1910                 1915                 1920             


Ser Pro  Thr Ser Pro Thr Tyr  Ser Pro Thr Ser Pro  Lys Gly Ser 
    1925                 1930                 1935             


Thr Tyr  Ser Pro Thr Ser Pro  Gly Tyr Ser Pro Thr  Ser Pro Thr 
    1940                 1945                 1950             


Tyr Ser  Leu Thr Ser Pro Ala  Ile Ser Pro Asp Asp  Ser Asp Glu 
    1955                 1960                 1965             


Glu Asn  
    1970 


<210>  172
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  173
<211>  1188
<212>  PRT
<213>  Homo sapiens

<400>  173

Met Ser Val Ala Cys Val Leu Lys Arg Lys Ala Val Leu Trp Gln Asp 
1               5                   10                  15      


Ser Phe Ser Pro His Leu Lys His His Pro Gln Glu Pro Ala Asn Pro 
            20                  25                  30          


Asn Met Pro Val Val Leu Thr Ser Gly Thr Gly Ser Gln Ala Gln Pro 
        35                  40                  45              


Gln Pro Ala Ala Asn Gln Ala Leu Ala Ala Gly Thr His Ser Ser Pro 
    50                  55                  60                  


Val Pro Gly Ser Ile Gly Val Ala Gly Arg Ser Gln Asp Asp Ala Met 
65                  70                  75                  80  


Val Asp Tyr Phe Phe Gln Arg Gln His Gly Glu Gln Leu Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Tyr Asn Asn Ser Lys His Arg Trp Pro Thr 
            100                 105                 110         


Gly Asp Asn Ile His Ala Glu His Gln Val Arg Ser Met Asp Glu Leu 
        115                 120                 125             


Asn His Asp Phe Gln Ala Leu Ala Leu Glu Gly Arg Ala Met Gly Glu 
    130                 135                 140                 


Gln Leu Leu Pro Gly Lys Lys Phe Trp Glu Thr Asp Glu Ser Ser Lys 
145                 150                 155                 160 


Asp Gly Pro Lys Gly Ile Phe Leu Gly Asp Gln Trp Arg Asp Ser Ala 
                165                 170                 175     


Trp Gly Thr Ser Asp His Ser Val Ser Gln Pro Ile Met Val Gln Arg 
            180                 185                 190         


Arg Pro Gly Gln Ser Phe His Val Asn Ser Glu Val Asn Ser Val Leu 
        195                 200                 205             


Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu Tyr 
    210                 215                 220                 


Val Leu Ser Ser Ser Pro Gly Asp Ser Cys Leu Arg Lys Gly Gly Phe 
225                 230                 235                 240 


Gly Pro Arg Asp Ala Asp Ser Asp Glu Asn Asp Lys Gly Glu Lys Lys 
                245                 250                 255     


Asn Lys Gly Thr Phe Asp Gly Asp Lys Leu Gly Asp Leu Lys Glu Glu 
            260                 265                 270         


Gly Asp Val Met Asp Lys Thr Asn Gly Leu Pro Val Gln Asn Gly Ile 
        275                 280                 285             


Asp Ala Asp Val Lys Asp Phe Ser Arg Thr Pro Gly Asn Cys Gln Asn 
    290                 295                 300                 


Ser Ala Asn Glu Val Asp Leu Leu Gly Pro Asn Gln Asn Gly Ser Glu 
305                 310                 315                 320 


Gly Leu Ala Gln Leu Thr Ser Thr Asn Gly Ala Lys Pro Val Glu Asp 
                325                 330                 335     


Phe Ser Asn Met Glu Ser Gln Ser Val Pro Leu Asp Pro Met Glu His 
            340                 345                 350         


Val Gly Met Glu Pro Leu Gln Phe Asp Tyr Ser Gly Thr Gln Val Pro 
        355                 360                 365             


Val Asp Ser Ala Ala Ala Thr Val Gly Leu Phe Asp Tyr Asn Ser Gln 
    370                 375                 380                 


Gln Gln Leu Phe Gln Arg Pro Asn Ala Leu Ala Val Gln Gln Leu Thr 
385                 390                 395                 400 


Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala Ala His Gln Pro His 
                405                 410                 415     


Ile Gly Leu Ala Pro Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser 
            420                 425                 430         


Ala Ala Pro Pro Gly Thr Asp Pro Tyr Thr Ala Gly Leu Ala Ala Ala 
        435                 440                 445             


Ala Thr Leu Gly Pro Ala Val Val Pro His Gln Tyr Tyr Gly Val Thr 
    450                 455                 460                 


Pro Trp Gly Val Tyr Pro Ala Ser Leu Phe Gln Gln Gln Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Asn Ser Ala Asn Gln Gln Thr Thr Pro Gln Ala 
                485                 490                 495     


Gln Gln Gly Gln Gln Gln Val Leu Arg Gly Gly Ala Ser Gln Arg Pro 
            500                 505                 510         


Leu Thr Pro Asn Gln Asn Gln Gln Gly Gln Gln Thr Asp Pro Leu Val 
        515                 520                 525             


Ala Ala Ala Ala Val Asn Ser Ala Leu Ala Phe Gly Gln Gly Leu Ala 
    530                 535                 540                 


Ala Gly Met Pro Gly Tyr Pro Val Leu Ala Pro Ala Ala Tyr Tyr Asp 
545                 550                 555                 560 


Gln Thr Gly Ala Leu Val Val Asn Ala Gly Ala Arg Asn Gly Leu Gly 
                565                 570                 575     


Ala Pro Val Arg Leu Val Ala Pro Ala Pro Val Ile Ile Ser Ser Ser 
            580                 585                 590         


Ala Ala Gln Ala Ala Val Ala Ala Ala Ala Ala Ser Ala Asn Gly Ala 
        595                 600                 605             


Ala Gly Gly Leu Ala Gly Thr Thr Asn Gly Pro Phe Arg Pro Leu Gly 
    610                 615                 620                 


Thr Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln Pro Asn Asn Asn Leu 
625                 630                 635                 640 


Ala Ser Ser Ser Phe Tyr Gly Asn Asn Ser Leu Asn Ser Asn Ser Gln 
                645                 650                 655     


Ser Ser Ser Leu Phe Ser Gln Gly Ser Ala Gln Pro Ala Asn Thr Ser 
            660                 665                 670         


Leu Gly Phe Gly Ser Ser Ser Ser Leu Gly Ala Thr Leu Gly Ser Ala 
        675                 680                 685             


Leu Gly Gly Phe Gly Thr Ala Val Ala Asn Ser Asn Thr Gly Ser Gly 
    690                 695                 700                 


Ser Arg Arg Asp Ser Leu Thr Gly Ser Ser Asp Leu Tyr Lys Arg Thr 
705                 710                 715                 720 


Ser Ser Ser Leu Thr Pro Ile Gly His Ser Phe Tyr Asn Gly Leu Ser 
                725                 730                 735     


Phe Ser Ser Ser Pro Gly Pro Val Gly Met Pro Leu Pro Ser Gln Gly 
            740                 745                 750         


Pro Gly His Ser Gln Thr Pro Pro Pro Ser Leu Ser Ser His Gly Ser 
        755                 760                 765             


Ser Ser Ser Leu Asn Leu Gly Gly Leu Thr Asn Gly Ser Gly Arg Tyr 
    770                 775                 780                 


Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys Tyr Arg Ser Ala Ser Ser 
785                 790                 795                 800 


Ala Ser Ser Leu Phe Ser Pro Ser Ser Thr Leu Phe Ser Ser Ser Arg 
                805                 810                 815     


Leu Arg Tyr Gly Met Ser Asp Val Met Pro Ser Gly Arg Ser Arg Leu 
            820                 825                 830         


Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu 
        835                 840                 845             


Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
    850                 855                 860                 


Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
865                 870                 875                 880 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                885                 890                 895     


Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            900                 905                 910         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        915                 920                 925             


Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe 
    930                 935                 940                 


Ile Pro Ser Asp Gln Gln Val Ile Asn Glu Met Val Arg Glu Leu Asp 
945                 950                 955                 960 


Gly His Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val 
                965                 970                 975     


Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile 
            980                 985                 990         


Asp Ala Phe Lys Gly Gln Val Phe  Ala Leu Ser Thr His  Pro Tyr Gly 
        995                 1000                 1005             


Cys Arg  Val Ile Gln Arg Ile  Leu Glu His Cys Leu  Pro Asp Gln 
    1010                 1015                 1020             


Thr Leu  Pro Ile Leu Glu Glu  Leu His Gln His Thr  Glu Gln Leu 
    1025                 1030                 1035             


Val Gln  Asp Gln Tyr Gly Asn  Tyr Val Ile Gln His  Val Leu Glu 
    1040                 1045                 1050             


His Gly  Arg Pro Glu Asp Lys  Ser Lys Ile Val Ala  Glu Ile Arg 
    1055                 1060                 1065             


Gly Asn  Val Leu Val Leu Ser  Gln His Lys Phe Ala  Ser Asn Val 
    1070                 1075                 1080             


Val Glu  Lys Cys Val Thr His  Ala Ser Arg Thr Glu  Arg Ala Val 
    1085                 1090                 1095             


Leu Ile  Asp Glu Val Cys Thr  Met Asn Asp Gly Pro  His Ser Ala 
    1100                 1105                 1110             


Leu Tyr  Thr Met Met Lys Asp  Gln Tyr Ala Asn Tyr  Val Val Gln 
    1115                 1120                 1125             


Lys Met  Ile Asp Val Ala Glu  Pro Gly Gln Arg Lys  Ile Val Met 
    1130                 1135                 1140             


His Lys  Ile Arg Pro His Ile  Ala Thr Leu Arg Lys  Tyr Thr Tyr 
    1145                 1150                 1155             


Gly Lys  His Ile Leu Ala Lys  Leu Glu Lys Tyr Tyr  Met Lys Asn 
    1160                 1165                 1170             


Gly Val  Asp Leu Gly Pro Ile  Cys Gly Pro Pro Asn  Gly Ile Ile 
    1175                 1180                 1185             


<210>  174
<211>  1186
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Ser Val Ala Cys Val Leu Lys Arg Lys Ala Val Leu Trp Gln Asp 
1               5                   10                  15      


Ser Phe Ser Pro His Leu Lys His His Pro Gln Glu Pro Ala Asn Pro 
            20                  25                  30          


Asn Met Pro Val Val Leu Thr Ser Gly Thr Gly Ser Gln Ala Gln Pro 
        35                  40                  45              


Gln Pro Ala Ala Asn Gln Ala Leu Ala Ala Gly Thr His Ser Ser Pro 
    50                  55                  60                  


Val Pro Gly Ser Ile Gly Val Ala Gly Arg Ser Gln Asp Asp Ala Met 
65                  70                  75                  80  


Val Asp Tyr Phe Phe Gln Arg Gln His Gly Glu Gln Leu Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly Gly Gly Tyr Asn Asn Ser Lys His Arg Trp Pro Thr 
            100                 105                 110         


Gly Asp Asn Ile His Ala Glu His Gln Val Arg Ser Met Asp Glu Leu 
        115                 120                 125             


Asn His Asp Phe Gln Ala Leu Ala Leu Glu Gly Arg Ala Met Gly Glu 
    130                 135                 140                 


Gln Leu Leu Pro Gly Lys Lys Phe Trp Glu Thr Asp Glu Ser Ser Lys 
145                 150                 155                 160 


Asp Gly Pro Lys Gly Ile Phe Leu Gly Asp Gln Trp Arg Asp Ser Ala 
                165                 170                 175     


Trp Gly Thr Ser Asp His Ser Val Ser Gln Pro Ile Met Val Gln Arg 
            180                 185                 190         


Arg Pro Gly Gln Ser Phe His Val Asn Ser Glu Val Asn Ser Val Leu 
        195                 200                 205             


Ser Pro Arg Ser Glu Ser Gly Gly Leu Gly Val Ser Met Val Glu Tyr 
    210                 215                 220                 


Val Leu Ser Ser Ser Pro Gly Asp Ser Cys Leu Arg Lys Gly Gly Phe 
225                 230                 235                 240 


Gly Pro Arg Asp Ala Asp Ser Asp Glu Asn Asp Lys Gly Glu Lys Lys 
                245                 250                 255     


Asn Lys Gly Thr Phe Asp Gly Asp Lys Leu Gly Asp Leu Lys Glu Glu 
            260                 265                 270         


Gly Asp Val Met Asp Lys Thr Asn Gly Leu Pro Val Gln Asn Gly Ile 
        275                 280                 285             


Asp Ala Asp Val Lys Asp Phe Ser Arg Thr Pro Gly Asn Cys Gln Asn 
    290                 295                 300                 


Ser Ala Asn Glu Val Asp Leu Leu Gly Pro Asn Gln Asn Gly Ser Glu 
305                 310                 315                 320 


Gly Leu Ala Gln Leu Thr Ser Thr Asn Gly Ala Lys Pro Val Glu Asp 
                325                 330                 335     


Phe Ser Asn Met Glu Ser Gln Ser Val Pro Leu Asp Pro Met Glu His 
            340                 345                 350         


Val Gly Met Glu Pro Leu Gln Phe Asp Tyr Ser Gly Thr Gln Val Pro 
        355                 360                 365             


Val Asp Ser Ala Ala Ala Thr Val Gly Leu Phe Asp Tyr Asn Ser Gln 
    370                 375                 380                 


Gln Gln Leu Phe Gln Arg Pro Asn Ala Leu Ala Val Gln Gln Leu Thr 
385                 390                 395                 400 


Ala Ala Gln Gln Gln Gln Tyr Ala Leu Ala Ala Ala His Gln Pro His 
                405                 410                 415     


Ile Gly Leu Ala Pro Ala Ala Phe Val Pro Asn Pro Tyr Ile Ile Ser 
            420                 425                 430         


Ala Ala Pro Pro Gly Thr Asp Pro Tyr Thr Ala Gly Leu Ala Ala Ala 
        435                 440                 445             


Ala Thr Leu Gly Pro Ala Val Val Pro His Gln Tyr Tyr Gly Val Thr 
    450                 455                 460                 


Pro Trp Gly Val Tyr Pro Ala Ser Leu Phe Gln Gln Gln Ala Ala Ala 
465                 470                 475                 480 


Ala Ala Ala Ala Thr Asn Ser Ala Asn Gln Gln Thr Thr Pro Gln Ala 
                485                 490                 495     


Gln Gln Gly Gln Gln Gln Val Leu Arg Gly Gly Ala Ser Gln Arg Pro 
            500                 505                 510         


Leu Thr Pro Asn Gln Asn Gln Gln Gly Gln Gln Thr Asp Pro Leu Val 
        515                 520                 525             


Ala Ala Ala Ala Val Asn Ser Ala Leu Ala Phe Gly Gln Gly Leu Ala 
    530                 535                 540                 


Ala Gly Met Pro Gly Tyr Pro Val Leu Ala Pro Ala Ala Tyr Tyr Asp 
545                 550                 555                 560 


Gln Thr Gly Ala Leu Val Val Asn Ala Gly Ala Arg Asn Gly Leu Gly 
                565                 570                 575     


Ala Pro Val Arg Leu Val Ala Pro Ala Pro Val Ile Ile Ser Ser Ser 
            580                 585                 590         


Ala Ala Gln Ala Ala Val Ala Ala Ala Ala Ala Ser Ala Asn Gly Ala 
        595                 600                 605             


Ala Gly Gly Leu Ala Gly Thr Thr Asn Gly Pro Phe Arg Pro Leu Gly 
    610                 615                 620                 


Thr Gln Gln Pro Gln Pro Gln Pro Gln Gln Gln Pro Asn Asn Asn Leu 
625                 630                 635                 640 


Ala Ser Ser Ser Phe Tyr Gly Asn Asn Ser Leu Asn Ser Asn Ser Gln 
                645                 650                 655     


Ser Ser Ser Leu Phe Ser Gln Gly Ser Ala Gln Pro Ala Asn Thr Ser 
            660                 665                 670         


Leu Gly Phe Gly Ser Ser Ser Ser Leu Gly Ala Thr Leu Gly Ser Ala 
        675                 680                 685             


Leu Gly Gly Phe Gly Thr Ala Val Ala Asn Ser Asn Thr Gly Ser Gly 
    690                 695                 700                 


Ser Arg Arg Asp Ser Leu Thr Gly Ser Ser Asp Leu Tyr Lys Arg Thr 
705                 710                 715                 720 


Ser Ser Ser Leu Thr Pro Ile Gly His Ser Phe Tyr Asn Gly Leu Ser 
                725                 730                 735     


Phe Ser Ser Ser Pro Gly Pro Val Gly Met Pro Leu Pro Ser Gln Gly 
            740                 745                 750         


Pro Gly His Ser Gln Thr Pro Pro Pro Ser Leu Ser Ser His Gly Ser 
        755                 760                 765             


Ser Ser Ser Leu Asn Leu Gly Gly Leu Thr Asn Gly Ser Gly Arg Tyr 
    770                 775                 780                 


Ile Ser Ala Ala Pro Gly Ala Glu Ala Lys Tyr Arg Ser Ala Ser Ser 
785                 790                 795                 800 


Ala Ser Ser Leu Phe Ser Pro Ser Ser Thr Leu Phe Ser Ser Ser Arg 
                805                 810                 815     


Leu Arg Tyr Gly Met Ser Asp Val Met Pro Ser Gly Arg Ser Arg Leu 
            820                 825                 830         


Leu Glu Asp Phe Arg Asn Asn Arg Tyr Pro Asn Leu Gln Leu Arg Glu 
        835                 840                 845             


Ile Ala Gly His Ile Met Glu Phe Ser Gln Asp Gln His Gly Ser Arg 
    850                 855                 860                 


Phe Ile Gln Leu Lys Leu Glu Arg Ala Thr Pro Ala Glu Arg Gln Leu 
865                 870                 875                 880 


Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln Leu Met Val Asp Val 
                885                 890                 895     


Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu Phe Gly Ser Leu Glu 
            900                 905                 910         


Gln Lys Leu Ala Leu Ala Glu Arg Ile Arg Gly His Val Leu Ser Leu 
        915                 920                 925             


Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln Lys Ala Leu Glu Phe 
    930                 935                 940                 


Ile Pro Ser Asp Gln Gln Asn Glu Met Val Arg Glu Leu Asp Gly His 
945                 950                 955                 960 


Val Leu Lys Cys Val Lys Asp Gln Asn Gly Asn His Val Val Gln Lys 
                965                 970                 975     


Cys Ile Glu Cys Val Gln Pro Gln Ser Leu Gln Phe Ile Ile Asp Ala 
            980                 985                 990         


Phe Lys Gly Gln Val Phe Ala Leu  Ser Thr His Pro Tyr  Gly Cys Arg 
        995                 1000                 1005             


Val Ile  Gln Arg Ile Leu Glu  His Cys Leu Pro Asp  Gln Thr Leu 
    1010                 1015                 1020             


Pro Ile  Leu Glu Glu Leu His  Gln His Thr Glu Gln  Leu Val Gln 
    1025                 1030                 1035             


Asp Gln  Tyr Gly Asn Tyr Val  Ile Gln His Val Leu  Glu His Gly 
    1040                 1045                 1050             


Arg Pro  Glu Asp Lys Ser Lys  Ile Val Ala Glu Ile  Arg Gly Asn 
    1055                 1060                 1065             


Val Leu  Val Leu Ser Gln His  Lys Phe Ala Ser Asn  Val Val Glu 
    1070                 1075                 1080             


Lys Cys  Val Thr His Ala Ser  Arg Thr Glu Arg Ala  Val Leu Ile 
    1085                 1090                 1095             


Asp Glu  Val Cys Thr Met Asn  Asp Gly Pro His Ser  Ala Leu Tyr 
    1100                 1105                 1110             


Thr Met  Met Lys Asp Gln Tyr  Ala Asn Tyr Val Val  Gln Lys Met 
    1115                 1120                 1125             


Ile Asp  Val Ala Glu Pro Gly  Gln Arg Lys Ile Val  Met His Lys 
    1130                 1135                 1140             


Ile Arg  Pro His Ile Ala Thr  Leu Arg Lys Tyr Thr  Tyr Gly Lys 
    1145                 1150                 1155             


His Ile  Leu Ala Lys Leu Glu  Lys Tyr Tyr Met Lys  Asn Gly Val 
    1160                 1165                 1170             


Asp Leu  Gly Pro Ile Cys Gly  Pro Pro Asn Gly Ile  Ile 
    1175                 1180                 1185     


<210>  175
<211>  451
<212>  PRT
<213>  Homo sapiens

<400>  175

Met Arg Glu Cys Ile Ser Ile His Val Gly Gln Ala Gly Val Gln Ile 
1               5                   10                  15      


Gly Asn Ala Cys Trp Glu Leu Tyr Cys Leu Glu His Gly Ile Gln Pro 
            20                  25                  30          


Asp Gly Gln Met Pro Ser Asp Lys Thr Ile Gly Gly Gly Asp Asp Ser 
        35                  40                  45              


Phe Asn Thr Phe Phe Ser Glu Thr Gly Ala Gly Lys His Val Pro Arg 
    50                  55                  60                  


Ala Val Phe Val Asp Leu Glu Pro Thr Val Ile Asp Glu Val Arg Thr 
65                  70                  75                  80  


Gly Thr Tyr Arg Gln Leu Phe His Pro Glu Gln Leu Ile Thr Gly Lys 
                85                  90                  95      


Glu Asp Ala Ala Asn Asn Tyr Ala Arg Gly His Tyr Thr Ile Gly Lys 
            100                 105                 110         


Glu Ile Ile Asp Leu Val Leu Asp Arg Ile Arg Lys Leu Ala Asp Gln 
        115                 120                 125             


Cys Thr Gly Leu Gln Gly Phe Leu Val Phe His Ser Phe Gly Gly Gly 
    130                 135                 140                 


Thr Gly Ser Gly Phe Thr Ser Leu Leu Met Glu Arg Leu Ser Val Asp 
145                 150                 155                 160 


Tyr Gly Lys Lys Ser Lys Leu Glu Phe Ser Ile Tyr Pro Ala Pro Gln 
                165                 170                 175     


Val Ser Thr Ala Val Val Glu Pro Tyr Asn Ser Ile Leu Thr Thr His 
            180                 185                 190         


Thr Thr Leu Glu His Ser Asp Cys Ala Phe Met Val Asp Asn Glu Ala 
        195                 200                 205             


Ile Tyr Asp Ile Cys Arg Arg Asn Leu Asp Ile Glu Arg Pro Thr Tyr 
    210                 215                 220                 


Thr Asn Leu Asn Arg Leu Ile Ser Gln Ile Val Ser Ser Ile Thr Ala 
225                 230                 235                 240 


Ser Leu Arg Phe Asp Gly Ala Leu Asn Val Asp Leu Thr Glu Phe Gln 
                245                 250                 255     


Thr Asn Leu Val Pro Tyr Pro Arg Ile His Phe Pro Leu Ala Thr Tyr 
            260                 265                 270         


Ala Pro Val Ile Ser Ala Glu Lys Ala Tyr His Glu Gln Leu Ser Val 
        275                 280                 285             


Ala Glu Ile Thr Asn Ala Cys Phe Glu Pro Ala Asn Gln Met Val Lys 
    290                 295                 300                 


Cys Asp Pro Arg His Gly Lys Tyr Met Ala Cys Cys Leu Leu Tyr Arg 
305                 310                 315                 320 


Gly Asp Val Val Pro Lys Asp Val Asn Ala Ala Ile Ala Thr Ile Lys 
                325                 330                 335     


Thr Lys Arg Ser Ile Gln Phe Val Asp Trp Cys Pro Thr Gly Phe Lys 
            340                 345                 350         


Val Gly Ile Asn Tyr Gln Pro Pro Thr Val Val Pro Gly Gly Asp Leu 
        355                 360                 365             


Ala Lys Val Gln Arg Ala Val Cys Met Leu Ser Asn Thr Thr Ala Ile 
    370                 375                 380                 


Ala Glu Ala Trp Ala Arg Leu Asp His Lys Phe Asp Leu Met Tyr Ala 
385                 390                 395                 400 


Lys Arg Ala Phe Val His Trp Tyr Val Gly Glu Gly Met Glu Glu Gly 
                405                 410                 415     


Glu Phe Ser Glu Ala Arg Glu Asp Met Ala Ala Leu Glu Lys Asp Tyr 
            420                 425                 430         


Glu Glu Val Gly Val Asp Ser Val Glu Gly Glu Gly Glu Glu Glu Gly 
        435                 440                 445             


Glu Glu Tyr 
    450     


<210>  176
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
1               5                   10                  15      


Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
            20                  25                  30          


Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
        35                  40                  45              


Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
    50                  55                  60                  


Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
65                  70                  75                  80  


Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                85                  90                  95      


Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
            100                 105                 110         


Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
        115                 120                 125             


Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
    130                 135                 140                 


Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
145                 150                 155                 160 


Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                165                 170                 175     


Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
            180                 185                 190         


Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
        195                 200                 205             


Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
    210                 215                 220                 


Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
225                 230                 235                 240 


Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                245                 250                 255     


Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
            260                 265                 270         


His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
        275                 280                 285             


Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
    290                 295                 300                 


Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
305                 310                 315                 320 


Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                325                 330                 335     


Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
            340                 345                 350         


Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
        355                 360                 365             


Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
    370                 375                 380                 


His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
385                 390                 395                 400 


Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                405                 410                 415     


Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
            420                 425                 430         


Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
        435                 440                 445             


Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
    450                 455                 460                 


Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
465                 470                 475                 480 


Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                485                 490                 495     


Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
            500                 505                 510         


Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
        515                 520                 525             


Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
    530                 535                 540                 


Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
545                 550                 555                 560 


Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                565                 570                 575     


His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
            580                 585                 590         


Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
        595                 600                 605             


Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
    610                 615                 620                 


Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
625                 630                 635                 640 


<210>  177
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  177

Met Glu Ser Val Val Arg Arg Cys Pro Phe Leu Ser Arg Val Pro Gln 
1               5                   10                  15      


Ala Phe Leu Gln Lys Ala Gly Lys Ser Leu Leu Phe Tyr Ala Gln Asn 
            20                  25                  30          


Cys Pro Lys Met Met Glu Val Gly Ala Lys Pro Ala Pro Arg Ala Leu 
        35                  40                  45              


Ser Thr Ala Ala Val His Tyr Gln Gln Ile Lys Glu Thr Pro Pro Ala 
    50                  55                  60                  


Ser Glu Lys Asp Lys Thr Ala Lys Ala Lys Val Gln Gln Thr Pro Asp 
65                  70                  75                  80  


Gly Ser Gln Gln Ser Pro Asp Gly Thr Gln Leu Pro Ser Gly His Pro 
                85                  90                  95      


Leu Pro Ala Thr Ser Gln Gly Thr Ala Ser Lys Cys Pro Phe Leu Ala 
            100                 105                 110         


Ala Gln Met Asn Gln Arg Gly Ser Ser Val Phe Cys Lys Ala Ser Leu 
        115                 120                 125             


Glu Leu Gln Glu Asp Val Gln Glu Met Asn Ala Val Arg Lys Glu Val 
    130                 135                 140                 


Ala Glu Thr Ser Ala Gly Pro Ser Val Val Ser Val Lys Thr Asp Gly 
145                 150                 155                 160 


Gly Asp Pro Ser Gly Leu Leu Lys Asn Phe Gln Asp Ile Met Gln Lys 
                165                 170                 175     


Gln Arg Pro Glu Arg Val Ser His Leu Leu Gln Asp Asn Leu Pro Lys 
            180                 185                 190         


Ser Val Ser Thr Phe Gln Tyr Asp Arg Phe Phe Glu Lys Lys Ile Asp 
        195                 200                 205             


Glu Lys Lys Asn Asp His Thr Tyr Arg Val Phe Lys Thr Val Asn Arg 
    210                 215                 220                 


Arg Ala His Ile Phe Pro Met Ala Asp Asp Tyr Ser Asp Ser Leu Ile 
225                 230                 235                 240 


Thr Lys Lys Gln Val Ser Val Trp Cys Ser Asn Asp Tyr Leu Gly Met 
                245                 250                 255     


Ser Arg His Pro Arg Val Cys Gly Ala Val Met Asp Thr Leu Lys Gln 
            260                 265                 270         


His Gly Ala Gly Ala Gly Gly Thr Arg Asn Ile Ser Gly Thr Ser Lys 
        275                 280                 285             


Phe His Val Asp Leu Glu Arg Glu Leu Ala Asp Leu His Gly Lys Asp 
    290                 295                 300                 


Ala Ala Leu Leu Phe Ser Ser Cys Phe Val Ala Asn Asp Ser Thr Leu 
305                 310                 315                 320 


Phe Thr Leu Ala Lys Met Met Pro Gly Cys Glu Ile Tyr Ser Asp Ser 
                325                 330                 335     


Gly Asn His Ala Ser Met Ile Gln Gly Ile Arg Asn Ser Arg Val Pro 
            340                 345                 350         


Lys Tyr Ile Phe Arg His Asn Asp Val Ser His Leu Arg Glu Leu Leu 
        355                 360                 365             


Gln Arg Ser Asp Pro Ser Val Pro Lys Ile Val Ala Phe Glu Thr Val 
    370                 375                 380                 


His Ser Met Asp Gly Ala Val Cys Pro Leu Glu Glu Leu Cys Asp Val 
385                 390                 395                 400 


Ala His Glu Phe Gly Ala Ile Thr Phe Val Asp Glu Val His Ala Val 
                405                 410                 415     


Gly Leu Tyr Gly Ala Arg Gly Gly Gly Ile Gly Asp Arg Asp Gly Val 
            420                 425                 430         


Met Pro Lys Met Asp Ile Ile Ser Gly Thr Leu Gly Lys Ala Phe Gly 
        435                 440                 445             


Cys Val Gly Gly Tyr Ile Ala Ser Thr Ser Ser Leu Ile Asp Thr Val 
    450                 455                 460                 


Arg Ser Tyr Ala Ala Gly Phe Ile Phe Thr Thr Ser Leu Pro Pro Met 
465                 470                 475                 480 


Leu Leu Ala Gly Ala Leu Glu Ser Val Arg Ile Leu Lys Ser Ala Glu 
                485                 490                 495     


Gly Arg Val Leu Arg Arg Gln His Gln Arg Asn Val Lys Leu Met Arg 
            500                 505                 510         


Gln Met Leu Met Asp Ala Gly Leu Pro Val Val His Cys Pro Ser His 
        515                 520                 525             


Ile Ile Pro Val Arg Val Ala Asp Ala Ala Lys Asn Thr Glu Val Cys 
    530                 535                 540                 


Asp Glu Leu Met Ser Arg His Asn Ile Tyr Val Gln Ala Ile Asn Tyr 
545                 550                 555                 560 


Pro Thr Val Pro Arg Gly Glu Glu Leu Leu Arg Ile Ala Pro Thr Pro 
                565                 570                 575     


His His Thr Pro Gln Met Met Asn Tyr Phe Leu Glu Asn Leu Leu Val 
            580                 585                 590         


Thr Trp Lys Gln Val Gly Leu Glu Leu Lys Pro His Ser Ser Ala Glu 
        595                 600                 605             


Cys Asn Phe Cys Arg Arg Pro Leu His Phe Glu Val Met Ser Glu Arg 
    610                 615                 620                 


Glu Lys Ser Tyr Phe Ser Gly Leu Ser Lys Leu Val Ser Ala Gln Ala 
625                 630                 635                 640 


<210>  178
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP_forward primer

<400>  178
gccaagaaga aagtgaacat cat                                               23


<210>  179
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP_reverse primer

<400>  179
atagggattc cgggagtcat                                                   20


<210>  180
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP probe

<400>  180
tcagaacaac agcctgccac ctta                                              24


<210>  181
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT1_forward primer

<400>  181
gaggatttgg aaagggtgtt tatt                                              24


<210>  182
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT1_reverse primer

<400>  182
acagagggct acaatgtgat g                                                 21


<210>  183
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT1 probe

<400>  183
acgtcttgct cgagatgtga tgaagg                                            26


<210>  184
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB_forward primer

<400>  184
ccaaccgcga gaagatga                                                     18


<210>  185
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB_reverse primer

<400>  185
ccagaggcgt acagggatag                                                   20


<210>  186
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ACTB probe

<400>  186
ccatgtacgt tgctatccag gct                                               23


<210>  187
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPLP0_forward primer

<400>  187
taaaccctgc gtggcaat                                                     18


<210>  188
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPLP0_reverse primer

<400>  188
acatttcgga taatcatcca atagttg                                           27


<210>  189
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RPLP0 probe

<400>  189
aagtagttgg acttccaggt cgcc                                              24


<210>  190
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  POLR2A_forward primer

<400>  190
agtcctgagt ccggatgaa                                                    19


<210>  191
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  POLR2A_reverse primer

<400>  191
cctccctcag tcgtctct                                                     18


<210>  192
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  POLR2A probe

<400>  192
tgacggaggg tggcatcaaa tacc                                              24


<210>  193
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M_forward primer

<400>  193
ccgtggcctt agctgtg                                                      17


<210>  194
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M_reverse primer

<400>  194
ctgctggatg acgtgagtaa a                                                 21


<210>  195
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B2M probe

<400>  195
tctctctttc tggcctggag gcta                                              24


<210>  196
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PUM1_forward primer

<400>  196
gccagcttgt cttcaatgaa at                                                22


<210>  197
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PUM1_reverse primer

<400>  197
caaagccagc ttctgttcaa g                                                 21


<210>  198
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PUM1 probe

<400>  198
atccaccatg agttggtagg cagc                                              24


<210>  199
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K-ALPHA-1_forward primer

<400>  199
tgactccttc aacaccttct tc                                                22


<210>  200
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K-ALPHA-1_reverse primer

<400>  200
tgccagtgcg aacttcat                                                     18


<210>  201
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K-ALPHA-1 probe

<400>  201
ccgggctgtg tttgtagact tgga                                              24


<210>  202
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALAS-1_forward primer

<400>  202
agccacatca tccctgt                                                      17


<210>  203
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALAS-1_reverse primer

<400>  203
cgtagatgtt atgtctgctc at                                                22


<210>  204
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ALAS-1 probe

<400>  204
tttagcagca tctgcaaccc gc                                                22


