                         SEQUENCE LISTING

<110>  Children's Hospital Medical Center
 
<120>  CDH26 BASED THERAPEUTIC AGENTS AND THEIR USE

<130>  47108-526001WO

<150>  62/168,087
<151>  2015-05-29

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAMRSGRHPSLLLLLVLLLWLLQVSII

<400>  1

Met Ala Met Arg Ser Gly Arg His Pro Ser Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Gln Val Ser Ile Ile 
            20                  25          


<210>  2
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC1

<400>  2

Pro Lys Leu Ile Gly Glu Leu Phe Asn Asn Met Ser Tyr Asn Met Ser 
1               5                   10                  15      


Leu Met Tyr Leu Ile Ser Gly Pro Gly Val Asp Glu Tyr Pro Glu Ile 
            20                  25                  30          


Gly Leu Phe Ser Leu Glu Asp His Glu Asn Gly Arg Ile Tyr Val His 
        35                  40                  45              


Arg Pro Val Asp Arg Glu Met Thr Pro Ser Phe Thr Val Tyr Phe Asp 
    50                  55                  60                  


Val Val Glu Arg Ser Thr Gly Lys Ile Val Asp Thr Ser Leu Ile Phe 
65                  70                  75                  80  


Asn Ile Arg Ile Ser Asp Val Asn Asp His Ala Pro 
                85                  90          


<210>  3
<211>  88
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC2

<400>  3

Gln Met Leu Ala Val Asp Leu Asp Glu Glu Asn Thr Pro Asn Ser Gln 
1               5                   10                  15      


Val Leu Tyr Phe Leu Ile Ser Gln Thr Pro Leu Leu Lys Glu Ser Gly 
            20                  25                  30          


Phe Arg Val Asp Arg Leu Ser Gly Glu Ile Arg Leu Ser Gly Cys Leu 
        35                  40                  45              


Asp Tyr Glu Thr Ala Pro Gln Phe Thr Leu Leu Ile Arg Ala Arg Asp 
    50                  55                  60                  


Cys Gly Glu Pro Ser Leu Ser Ser Thr Thr Thr Val His Val Asp Val 
65                  70                  75                  80  


Gln Glu Gly Asn Asn His Arg Pro 
                85              


<210>  4
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC3

<400>  4

Leu Leu Val Gln Asp Arg Asp Ser Pro Phe Thr Ser Ala Trp Arg Ala 
1               5                   10                  15      


Lys Phe Asn Ile Leu His Gly Asn Glu Glu Gly His Phe Asp Ile Ser 
            20                  25                  30          


Thr Asp Pro Glu Thr Asn Glu Gly Ile Leu Asn Val Ile Lys Pro Leu 
        35                  40                  45              


Asp Tyr Glu Thr Arg Pro Ala Gln Ser Leu Ile Ile Val Val Glu Asn 
    50                  55                  60                  


Glu Glu Arg Leu Val Phe Cys Glu Arg Gly Lys Leu Gln Pro Pro Arg 
65                  70                  75                  80  


Lys Ala Ala Ala Ser Ala Thr Val Ser Val Gln Val Thr Asp Ala Asn 
                85                  90                  95      


Asp Pro Pro Ala Phe 
            100     


<210>  5
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC4

<400>  5

Phe Asn Ala Met Asp Pro Asp Ser Gln Ile Arg Tyr Glu Leu Val His 
1               5                   10                  15      


Asp Pro Ala Asn Trp Val Ser Val Asp Lys Asn Ser Gly Val Val Ile 
            20                  25                  30          


Thr Val Glu Pro Ile Asp Arg Glu Ser Pro His Val Asn Asn Ser Phe 
        35                  40                  45              


Tyr Val Ile Ile Ile His Ala Val Asp Asp Gly Phe Pro Pro Gln Thr 
    50                  55                  60                  


Ala Thr Gly Thr Leu Met Leu Phe Leu Ser Asp Ile Asn Asp Asn Val 
65                  70                  75                  80  


Pro 
    


<210>  6
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EC5

<400>  6

Arg Tyr Met Glu Val Cys Glu Ser Ala Val His Glu Pro Leu His Ile 
1               5                   10                  15      


Glu Ala Glu Asp Pro Asp Leu Glu Pro Phe Ser Asp Pro Phe Thr Phe 
            20                  25                  30          


Glu Leu Asp Asn Thr Trp Gly Asn Ala Glu Asp Thr Trp Lys Leu Gly 
        35                  40                  45              


Arg Asn Trp Gly Gln Ser Val Glu Leu Leu Thr Leu Arg Ser Leu Pro 
    50                  55                  60                  


Arg Gly Asn Tyr Leu Val Pro Leu Phe Ile Gly Asp Lys Gln Gly Leu 
65                  70                  75                  80  


Ser Gln Lys Gln Val His Val Arg Ile Cys 
                85                  90  


<210>  7
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fc

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  8
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Met Arg Ser Gly Arg His Pro Ser Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Gln Val Ser Ile Ile Asp Ser Val Gln Gln 
            20                  25                  30          


Glu Thr Asp Asp Leu Thr Lys Gln Thr Lys Glu Lys Ile Tyr Gln Pro 
        35                  40                  45              


Leu Arg Arg Ser Lys Arg Arg Trp Val Ile Thr Thr Leu Glu Leu Glu 
    50                  55                  60                  


Glu Glu Asp Pro Gly Pro Phe Pro Lys Leu Ile Gly Glu Leu Phe Asn 
65                  70                  75                  80  


Asn Met Ser Tyr Asn Met Ser Leu Met Tyr Leu Ile Ser Gly Pro Gly 
                85                  90                  95      


Val Asp Glu Tyr Pro Glu Ile Gly Leu Phe Ser Leu Glu Asp His Glu 
            100                 105                 110         


Asn Gly Arg Ile Tyr Val His Arg Pro Val Asp Arg Glu Met Thr Pro 
        115                 120                 125             


Ser Phe Thr Val Tyr Phe Asp Val Val Glu Arg Ser Thr Gly Lys Ile 
    130                 135                 140                 


Val Asp Thr Ser Leu Ile Phe Asn Ile Arg Ile Ser Asp Val Asn Asp 
145                 150                 155                 160 


His Ala Pro Gln Phe Pro Glu Lys Glu Phe Asn Ile Thr Val Gln Glu 
                165                 170                 175     


Asn Gln Ser Ala Gly Gln Pro Ile Phe Gln Met Leu Ala Val Asp Leu 
            180                 185                 190         


Asp Glu Glu Asn Thr Pro Asn Ser Gln Val Leu Tyr Phe Leu Ile Ser 
        195                 200                 205             


Gln Thr Pro Leu Leu Lys Glu Ser Gly Phe Arg Val Asp Arg Leu Ser 
    210                 215                 220                 


Gly Glu Ile Arg Leu Ser Gly Cys Leu Asp Tyr Glu Thr Ala Pro Gln 
225                 230                 235                 240 


Phe Thr Leu Leu Ile Arg Ala Arg Asp Cys Gly Glu Pro Ser Leu Ser 
                245                 250                 255     


Ser Thr Thr Thr Val His Val Asp Val Gln Glu Gly Asn Asn His Arg 
            260                 265                 270         


Pro Ala Phe Thr Gln Glu Asn Tyr Lys Val Gln Ile Pro Glu Gly Arg 
        275                 280                 285             


Ala Ser Gln Gly Val Leu Arg Leu Leu Val Gln Asp Arg Asp Ser Pro 
    290                 295                 300                 


Phe Thr Ser Ala Trp Arg Ala Lys Phe Asn Ile Leu His Gly Asn Glu 
305                 310                 315                 320 


Glu Gly His Phe Asp Ile Ser Thr Asp Pro Glu Thr Asn Glu Gly Ile 
                325                 330                 335     


Leu Asn Val Ile Lys Pro Leu Asp Tyr Glu Thr Arg Pro Ala Gln Ser 
            340                 345                 350         


Leu Ile Ile Val Val Glu Asn Glu Glu Arg Leu Val Phe Cys Glu Arg 
        355                 360                 365             


Gly Lys Leu Gln Pro Pro Arg Lys Ala Ala Ala Ser Ala Thr Val Ser 
    370                 375                 380                 


Val Gln Val Thr Asp Ala Asn Asp Pro Pro Ala Phe His Pro Gln Ser 
385                 390                 395                 400 


Phe Ile Val Asn Lys Glu Glu Gly Ala Arg Pro Gly Thr Leu Leu Gly 
                405                 410                 415     


Thr Phe Asn Ala Met Asp Pro Asp Ser Gln Ile Arg Tyr Glu Leu Val 
            420                 425                 430         


His Asp Pro Ala Asn Trp Val Ser Val Asp Lys Asn Ser Gly Val Val 
        435                 440                 445             


Ile Thr Val Glu Pro Ile Asp Arg Glu Ser Pro His Val Asn Asn Ser 
    450                 455                 460                 


Phe Tyr Val Ile Ile Ile His Ala Val Asp Asp Gly Phe Pro Pro Gln 
465                 470                 475                 480 


Thr Ala Thr Gly Thr Leu Met Leu Phe Leu Ser Asp Ile Asn Asp Asn 
                485                 490                 495     


Val Pro Thr Leu Arg Pro Arg Ser Arg Tyr Met Glu Val Cys Glu Ser 
            500                 505                 510         


Ala Val His Glu Pro Leu His Ile Glu Ala Glu Asp Pro Asp Leu Glu 
        515                 520                 525             


Pro Phe Ser Asp Pro Phe Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn 
    530                 535                 540                 


Ala Glu Asp Thr Trp Lys Leu Gly Arg Asn Trp Gly Gln Ser Val Glu 
545                 550                 555                 560 


Leu Leu Thr Leu Arg Ser Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu 
                565                 570                 575     


Phe Ile Gly Asp Lys Gln Gly Leu Ser Gln Lys Gln Thr Val His Val 
            580                 585                 590         


Arg Ile Cys Pro Cys Ala Ser Gly Leu Thr Cys Val Glu Leu Ala Asp 
        595                 600                 605             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    610                 615                 620                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
625                 630                 635                 640 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                645                 650                 655     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            660                 665                 670         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        675                 680                 685             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    690                 695                 700                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
705                 710                 715                 720 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                725                 730                 735     


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
            740                 745                 750         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        755                 760                 765             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    770                 775                 780                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
785                 790                 795                 800 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                805                 810                 815     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            820                 825                 830         


Pro Gly Lys 
        835 


<210>  9
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  9
atggccatga gatccgggag gcacccctcg ctgctgctgc ttctagtgct gctgctgtgg       60

ctgctgcagg tcagtatcat tgacagtgtt caacaggaaa cagatgatct tactaagcaa      120

acaaaggaaa agatctacca gcctctacgg cgatccaaga gaagatgggt tatcaccacc      180

ttggagctgg aggaggaaga cccgggaccc tttcccaaac tcattggtga gctgttcaat      240

aatatgtctt ataacatgtc actaatgtat ctaatcagtg gacctggtgt ggatgaatat      300

ccagagattg gtttgttttc tctagaagat catgagaacg gaaggatata tgttcaccgc      360

cctgtcgatc gagaaatgac accatctttc acggtttatt ttgatgttgt ggagcgctca      420

acaggaaaaa ttgtggatac atccttgatt ttcaacatta ggatcagtga tgtgaatgat      480

catgcacccc agtttccaga gaaggaattt aacatcactg tgcaagaaaa ccaatctgca      540

gggcaaccta tttttcagat gttagcagtc gatttggatg aagaaaacac tccaaattct      600

caagtccttt acttcctcat ttctcaaaca ccattactga aagaaagtgg tttccgggtt      660

gatcgcctta gtggagaaat acgactctct ggctgcttag attatgagac cgctcctcag      720

tttacactgc taatcagagc cagggactgt ggagaaccgt cactgtcatc cacgaccacc      780

gttcacgtgg atgtgcaaga aggcaacaac cacaggcctg catttaccca ggagaactat      840

aaggttcaga ttcctgaagg ccgagccagc cagggcgtgt tgcgtctcct ggttcaagat      900

cgagattctc catttacatc agcttggaga gcaaaattca acatattgca tggcaatgaa      960

gaggggcatt ttgacatttc gactgaccct gagaccaacg aagggatatt aaatgttatc     1020

aagcctttgg attatgagac tcgcccagcg caaagcctca tcattgtcgt ggagaatgag     1080

gagaggctcg tcttctgtga gagaggaaag cttcagccgc caaggaaggc agcagccagc     1140

gccactgtga gtgtgcaggt gacagacgcc aacgacccac cagcctttca cccccagagc     1200

ttcattgtca ataaagagga gggcgccagg cctgggaccc tgttgggaac ttttaatgcc     1260

atggatccag acagccagat aagatatgaa ctggttcatg acccagcaaa ttgggtcagc     1320

gtcgacaaaa actccggagt ggtcatcacc gtggagccaa ttgaccgaga atcccctcat     1380

gtaaataaca gtttttatgt aatcatcatt cacgctgttg atgatggctt cccaccgcag     1440

actgctacag ggaccctaat gctcttcctg tctgacatca atgacaacgt cccgactctc     1500

cggccacgtt cccgctacat ggaggtctgt gagtctgctg tgcatgagcc cctccacatc     1560

gaggcagagg atccggacct ggagccgttc tctgacccat ttacatttga attggacaat     1620

acctggggaa atgcggagga cacatggaag ttggggagaa attggggtca atcagttgaa     1680

cttttaacct tgagaagcct gccacgtggt aattacttgg tgccactctt cattggagac     1740

aaacagggac tttcccagaa gcaaactgtc catgtaagga tctgcccctg tgccagtggg     1800

ctcacatgtg tggagcttgc agatgacaaa actcacacat gcccaccgtg cccagcacct     1860

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg     1920

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag     1980

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg     2040

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     2100

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     2160

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     2220

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     2280

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     2340

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     2400

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca cgaggctctg     2460

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaatga                  2508


<210>  10
<211>  545
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  segment 1 comprises or consists of the CDH26 extracellular region
       defined by amino acids asparagine 55 (Asp55) to serine 599 
       (Ser599)

<400>  10

Arg Trp Val Ile Thr Thr Leu Glu Leu Glu Glu Glu Asp Pro Gly Pro 
1               5                   10                  15      


Phe Pro Lys Leu Ile Gly Glu Leu Phe Asn Asn Met Ser Tyr Asn Met 
            20                  25                  30          


Ser Leu Met Tyr Leu Ile Ser Gly Pro Gly Val Asp Glu Tyr Pro Glu 
        35                  40                  45              


Ile Gly Leu Phe Ser Leu Glu Asp His Glu Asn Gly Arg Ile Tyr Val 
    50                  55                  60                  


His Arg Pro Val Asp Arg Glu Met Thr Pro Ser Phe Thr Val Tyr Phe 
65                  70                  75                  80  


Asp Val Val Glu Arg Ser Thr Gly Lys Ile Val Asp Thr Ser Leu Ile 
                85                  90                  95      


Phe Asn Ile Arg Ile Ser Asp Val Asn Asp His Ala Pro Gln Phe Pro 
            100                 105                 110         


Glu Lys Glu Phe Asn Ile Thr Val Gln Glu Asn Gln Ser Ala Gly Gln 
        115                 120                 125             


Pro Ile Phe Gln Met Leu Ala Val Asp Leu Asp Glu Glu Asn Thr Pro 
    130                 135                 140                 


Asn Ser Gln Val Leu Tyr Phe Leu Ile Ser Gln Thr Pro Leu Leu Lys 
145                 150                 155                 160 


Glu Ser Gly Phe Arg Val Asp Arg Leu Ser Gly Glu Ile Arg Leu Ser 
                165                 170                 175     


Gly Cys Leu Asp Tyr Glu Thr Ala Pro Gln Phe Thr Leu Leu Ile Arg 
            180                 185                 190         


Ala Arg Asp Cys Gly Glu Pro Ser Leu Ser Ser Thr Thr Thr Val His 
        195                 200                 205             


Val Asp Val Gln Glu Gly Asn Asn His Arg Pro Ala Phe Thr Gln Glu 
    210                 215                 220                 


Asn Tyr Lys Val Gln Ile Pro Glu Gly Arg Ala Ser Gln Gly Val Leu 
225                 230                 235                 240 


Arg Leu Leu Val Gln Asp Arg Asp Ser Pro Phe Thr Ser Ala Trp Arg 
                245                 250                 255     


Ala Lys Phe Asn Ile Leu His Gly Asn Glu Glu Gly His Phe Asp Ile 
            260                 265                 270         


Ser Thr Asp Pro Glu Thr Asn Glu Gly Ile Leu Asn Val Ile Lys Pro 
        275                 280                 285             


Leu Asp Tyr Glu Thr Arg Pro Ala Gln Ser Leu Ile Ile Val Val Glu 
    290                 295                 300                 


Asn Glu Glu Arg Leu Val Phe Cys Glu Arg Gly Lys Leu Gln Pro Pro 
305                 310                 315                 320 


Arg Lys Ala Ala Ala Ser Ala Thr Val Ser Val Gln Val Thr Asp Ala 
                325                 330                 335     


Asn Asp Pro Pro Ala Phe His Pro Gln Ser Phe Ile Val Asn Lys Glu 
            340                 345                 350         


Glu Gly Ala Arg Pro Gly Thr Leu Leu Gly Thr Phe Asn Ala Met Asp 
        355                 360                 365             


Pro Asp Ser Gln Ile Arg Tyr Glu Leu Val His Asp Pro Ala Asn Trp 
    370                 375                 380                 


Val Ser Val Asp Lys Asn Ser Gly Val Val Ile Thr Val Glu Pro Ile 
385                 390                 395                 400 


Asp Arg Glu Ser Pro His Val Asn Asn Ser Phe Tyr Val Ile Ile Ile 
                405                 410                 415     


His Ala Val Asp Asp Gly Phe Pro Pro Gln Thr Ala Thr Gly Thr Leu 
            420                 425                 430         


Met Leu Phe Leu Ser Asp Ile Asn Asp Asn Val Pro Thr Leu Arg Pro 
        435                 440                 445             


Arg Ser Arg Tyr Met Glu Val Cys Glu Ser Ala Val His Glu Pro Leu 
    450                 455                 460                 


His Ile Glu Ala Glu Asp Pro Asp Leu Glu Pro Phe Ser Asp Pro Phe 
465                 470                 475                 480 


Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn Ala Glu Asp Thr Trp Lys 
                485                 490                 495     


Leu Gly Arg Asn Trp Gly Gln Ser Val Glu Leu Leu Thr Leu Arg Ser 
            500                 505                 510         


Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu Phe Ile Gly Asp Lys Gln 
        515                 520                 525             


Gly Leu Ser Gln Lys Gln Thr Val His Val Arg Ile Cys Pro Cys Ala 
    530                 535                 540                 


Ser 
545 


<210>  11
<211>  832
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Met Arg Ser Gly Arg His Pro Ser Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Leu Leu Leu Trp Leu Leu Gln Val Ser Ile Ile Asp Ser Val Gln Gln 
            20                  25                  30          


Glu Thr Asp Asp Leu Thr Lys Gln Thr Lys Glu Lys Ile Tyr Gln Pro 
        35                  40                  45              


Leu Arg Arg Ser Lys Arg Arg Trp Val Ile Thr Thr Leu Glu Leu Glu 
    50                  55                  60                  


Glu Glu Asp Pro Gly Pro Phe Pro Lys Leu Ile Gly Glu Leu Phe Asn 
65                  70                  75                  80  


Asn Met Ser Tyr Asn Met Ser Leu Met Tyr Leu Ile Ser Gly Pro Gly 
                85                  90                  95      


Val Asp Glu Tyr Pro Glu Ile Gly Leu Phe Ser Leu Glu Asp His Glu 
            100                 105                 110         


Asn Gly Arg Ile Tyr Val His Arg Pro Val Asp Arg Glu Met Thr Pro 
        115                 120                 125             


Ser Phe Thr Val Tyr Phe Asp Val Val Glu Arg Ser Thr Gly Lys Ile 
    130                 135                 140                 


Val Asp Thr Ser Leu Ile Phe Asn Ile Arg Ile Ser Asp Val Asn Asp 
145                 150                 155                 160 


His Ala Pro Gln Phe Pro Glu Lys Glu Phe Asn Ile Thr Val Gln Glu 
                165                 170                 175     


Asn Gln Ser Ala Gly Gln Pro Ile Phe Gln Met Leu Ala Val Asp Leu 
            180                 185                 190         


Asp Glu Glu Asn Thr Pro Asn Ser Gln Val Leu Tyr Phe Leu Ile Ser 
        195                 200                 205             


Gln Thr Pro Leu Leu Lys Glu Ser Gly Phe Arg Val Asp Arg Leu Ser 
    210                 215                 220                 


Gly Glu Ile Arg Leu Ser Gly Cys Leu Asp Tyr Glu Thr Ala Pro Gln 
225                 230                 235                 240 


Phe Thr Leu Leu Ile Arg Ala Arg Asp Cys Gly Glu Pro Ser Leu Ser 
                245                 250                 255     


Ser Thr Thr Thr Val His Val Asp Val Gln Glu Gly Asn Asn His Arg 
            260                 265                 270         


Pro Ala Phe Thr Gln Glu Asn Tyr Lys Val Gln Ile Pro Glu Gly Arg 
        275                 280                 285             


Ala Ser Gln Gly Val Leu Arg Leu Leu Val Gln Asp Arg Asp Ser Pro 
    290                 295                 300                 


Phe Thr Ser Ala Trp Arg Ala Lys Phe Asn Ile Leu His Gly Asn Glu 
305                 310                 315                 320 


Glu Gly His Phe Asp Ile Ser Thr Asp Pro Glu Thr Asn Glu Gly Ile 
                325                 330                 335     


Leu Asn Val Ile Lys Pro Leu Asp Tyr Glu Thr Arg Pro Ala Gln Ser 
            340                 345                 350         


Leu Ile Ile Val Val Glu Asn Glu Glu Arg Leu Val Phe Cys Glu Arg 
        355                 360                 365             


Gly Lys Leu Gln Pro Pro Arg Lys Ala Ala Ala Ser Ala Thr Val Ser 
    370                 375                 380                 


Val Gln Val Thr Asp Ala Asn Asp Pro Pro Ala Phe His Pro Gln Ser 
385                 390                 395                 400 


Phe Ile Val Asn Lys Glu Glu Gly Ala Arg Pro Gly Thr Leu Leu Gly 
                405                 410                 415     


Thr Phe Asn Ala Met Asp Pro Asp Ser Gln Ile Arg Tyr Glu Leu Val 
            420                 425                 430         


His Asp Pro Ala Asn Trp Val Ser Val Asp Lys Asn Ser Gly Val Val 
        435                 440                 445             


Ile Thr Val Glu Pro Ile Asp Arg Glu Ser Pro His Val Asn Asn Ser 
    450                 455                 460                 


Phe Tyr Val Ile Ile Ile His Ala Val Asp Asp Gly Phe Pro Pro Gln 
465                 470                 475                 480 


Thr Ala Thr Gly Thr Leu Met Leu Phe Leu Ser Asp Ile Asn Asp Asn 
                485                 490                 495     


Val Pro Thr Leu Arg Pro Arg Ser Arg Tyr Met Glu Val Cys Glu Ser 
            500                 505                 510         


Ala Val His Glu Pro Leu His Ile Glu Ala Glu Asp Pro Asp Leu Glu 
        515                 520                 525             


Pro Phe Ser Asp Pro Phe Thr Phe Glu Leu Asp Asn Thr Trp Gly Asn 
    530                 535                 540                 


Ala Glu Asp Thr Trp Lys Leu Gly Arg Asn Trp Gly Gln Ser Val Glu 
545                 550                 555                 560 


Leu Leu Thr Leu Arg Ser Leu Pro Arg Gly Asn Tyr Leu Val Pro Leu 
                565                 570                 575     


Phe Ile Gly Asp Lys Gln Gly Leu Ser Gln Lys Gln Thr Val His Val 
            580                 585                 590         


Arg Ile Cys Pro Cys Ala Ser Gly Leu Thr Cys Val Glu Leu Ala Asp 
        595                 600                 605             


Ala Glu Val Gly Leu His Val Gly Ala Leu Phe Pro Val Cys Ala Ala 
    610                 615                 620                 


Phe Val Ala Leu Ala Val Ala Leu Leu Phe Leu Leu Arg Cys Tyr Phe 
625                 630                 635                 640 


Val Leu Glu Pro Lys Arg His Gly Cys Ser Val Ser Asn Asp Glu Gly 
                645                 650                 655     


His Gln Thr Leu Val Met Tyr Asn Ala Glu Ser Lys Gly Thr Ser Ala 
            660                 665                 670         


Gln Thr Trp Ser Asp Val Glu Gly Gln Arg Pro Ala Leu Leu Ile Cys 
        675                 680                 685             


Thr Ala Ala Ala Gly Pro Thr Gln Gly Val Lys Asp Leu Glu Glu Val 
    690                 695                 700                 


Pro Pro Ser Ala Ala Ser Gln Ser Ala Gln Ala Arg Cys Ala Leu Gly 
705                 710                 715                 720 


Ser Trp Gly Tyr Gly Lys Pro Phe Glu Pro Arg Ser Val Lys Asn Ile 
                725                 730                 735     


His Ser Thr Pro Ala Tyr Pro Asp Ala Thr Met His Arg Gln Leu Leu 
            740                 745                 750         


Ala Pro Val Glu Gly Arg Met Ala Glu Thr Leu Asn Gln Lys Leu His 
        755                 760                 765             


Val Ala Asn Val Leu Glu Asp Asp Pro Gly Tyr Leu Pro His Val Tyr 
    770                 775                 780                 


Ser Glu Glu Gly Glu Cys Gly Gly Ala Pro Ser Leu Ser Ser Leu Ala 
785                 790                 795                 800 


Ser Leu Glu Gln Glu Leu Gln Pro Asp Leu Leu Asp Ser Leu Gly Ser 
                805                 810                 815     


Lys Ala Thr Pro Phe Glu Glu Ile Tyr Ser Glu Ser Gly Val Pro Ser 
            820                 825                 830         


