                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  AAV-MEDIATED EXPRESSION OF SYTHETIC ANTI-AAV ANTIBODIES AND 
       METHODS OF USE THEREOF

<130>  UPN-15-7484PCT

<150>  62/323,348
<151>  2016-04-15

<150>  62/161,192
<151>  2015-05-13

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  7908
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Plasmid carrying FI6cc HC with germline light chain


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  repeat_region
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  promoter
<222>  (582)..(862)

<220>
<221>  TATA_signal
<222>  (836)..(839)

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1940)..(1987)
<223>  c-myc 5'UTR

<220>
<221>  misc_feature
<222>  (1988)..(1992)
<223>  kozak

<220>
<221>  misc_feature
<222>  (1993)..(2052)
<223>  leader

<220>
<221>  CDS
<222>  (2053)..(2439)
<223>  FI6 variable heavy

<220>
<221>  CDS
<222>  (2440)..(2760)
<223>  FI6 CH1

<220>
<221>  CDS
<222>  (2761)..(3426)
<223>  FI6 CH2-3

<220>
<221>  misc_feature
<222>  (3427)..(3438)
<223>  furin cleavage site

<220>
<221>  misc_feature
<222>  (3439)..(3510)
<223>  F2A

<220>
<221>  misc_feature
<222>  (3511)..(3570)
<223>  leader

<220>
<221>  CDS
<222>  (3511)..(3570)
<223>  leader

<220>
<221>  CDS
<222>  (3571)..(3909)
<223>  kagga germline line

<220>
<221>  CDS
<222>  (3910)..(4230)

<220>
<221>  repeat_region
<222>  (4308)..(4432)
<223>  rabbit globin polyA

<220>
<221>  repeat_region
<222>  (4521)..(4650)
<223>  3' ITR

<220>
<221>  misc_feature
<222>  (4827)..(5265)
<223>  F1 ori on complementary strand

<220>
<221>  misc_feature
<222>  (5294)..(5936)
<223>  origin of replication

<220>
<221>  misc_feature
<222>  (6611)..(7426)
<223>  CDS for Kan resistance located on complementary strand

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttcgctagcg ggcactttgc actggaactt acaacacccg agcaaggacg     1980

cgactctcca ccatgtacag aatgcagctg ctgagctgca tcgccctgag cctggccctg     2040

gtgaccaaca gc cag gtg caa cta gtg gag agc gga gga gga gtg gtg cag     2091
              Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln         
              1               5                   10                      

cca gga cgg agc ctg cgg ctg agc tgc gcc gcc agc gga ttc acc ttc       2139
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe           
    15                  20                  25                            

agc acc tac gcc atg cac tgg gtg cgg cag gcc cca gga aag gga ctg       2187
Ser Thr Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu           
30                  35                  40                  45            

gag tgg gtg gcc gtg atc agc tac gat gcc aac tac aag tac tac gcc       2235
Glu Trp Val Ala Val Ile Ser Tyr Asp Ala Asn Tyr Lys Tyr Tyr Ala           
                50                  55                  60                

gat agc gtg aag gga cgg ttc acc atc agc cgg gat aac agc aag aac       2283
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn           
            65                  70                  75                    

acc ctg tac ctg cag atg aac agc ctg cgg gcc gag gat acc gcc gtg       2331
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val           
        80                  85                  90                        

tac tac tgc gcc aag gat agc cag ctg cgg agc ctg ctg tac ttc gag       2379
Tyr Tyr Cys Ala Lys Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu           
    95                  100                 105                           

tgg ctg agc cag gga tac ttc gat tac tgg gga cag gga acc ctg gtg       2427
Trp Leu Ser Gln Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val           
110                 115                 120                 125           

acc gtg agc agc gcc agc acc aag ggg ccc agc gtg ttc cca ctg gcc       2475
Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala           
                130                 135                 140               

cca agc agc aag agc acc agc gga gga acc gcc gcc ctg gga tgc ctg       2523
Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu           
            145                 150                 155                   

gtg aag gat tac ttc cca gag cca gtg acc gtg agc tgg aac agc gga       2571
Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly           
        160                 165                 170                       

gcc ctg acc agc gga gtg cac acc ttc cca gcc gtg ctg cag agc agc       2619
Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser           
    175                 180                 185                           

gga ctg tat agc ctg agc agc gtg gtg acc gtg cca agc agc agc ctg       2667
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu           
190                 195                 200                 205           

gga acc cag acc tac atc tgc aac gtg aac cac aag cca agc aac acc       2715
Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr           
                210                 215                 220               

aag gtg gat aag aag gtg gag cca aag agc tgc gat aag acc cac acg       2763
Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr           
            225                 230                 235                   

tgc cct cca tgt cca gcc ccc gaa ctg ctg ggc ggg cct agc gtg ttc       2811
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe           
        240                 245                 250                       

ctg ttt ccc cct aag cct aaa gat aca ctg atg att agt aga acc cca       2859
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro           
    255                 260                 265                           

gag gtc aca tgc gtg gtc gtg gac gtg tcc cac gaa gag cct gac gtg       2907
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Glu Pro Asp Val           
270                 275                 280                 285           

aag ttc aac tgg tac gtg gat ggc gtg gag gtg cac aat gct aag act       2955
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr           
                290                 295                 300               

aaa cca cgc gaa gag cag tat aat agt aca tac cga gtc gtg tca gtc       3003
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val           
            305                 310                 315                   

ctg aca gtg ctg cac cag gat tgg ctg aac ggc aag gag tat aag tgc       3051
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys           
        320                 325                 330                       

aag gtg tct aac aag gcc ctg ccc gcc cct atc gag aaa aca att agc       3099
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser           
    335                 340                 345                           

aag gcc aaa ggg cag cca cgg gaa ccc cag gtc tac act ctg cca ccc       3147
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro           
350                 355                 360                 365           

tca aga gat gaa ctg act aag aac cag gtc agc ctg acc tgt ctg gtg       3195
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val           
                370                 375                 380               

aaa ggc ttc tac ccc agc gac atc gcc gtg gag tgg gaa agt aac ggc       3243
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly           
            385                 390                 395                   

cag cct gag aat aac tac aag act acc cct cca gtg ctg gat agc gac       3291
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp           
        400                 405                 410                       

ggg tcc ttc ttc ctg tat agc aag ctg aca gtg gac aaa tcc cgc tgg       3339
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp           
    415                 420                 425                           

cag cag gga aac gtc ttt tcc tgt tct gtg atg cat gag gcc ctg cac       3387
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His           
430                 435                 440                 445           

aat cat tac acc cag aag agt ctg tca ctg agc ccc ggc agaaagcgga        3436
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                       
                450                 455                                   

gagcccccgt gaagcagacc ctgaacttcg acctgctgaa gctggccggc gacgtggaaa     3496

gcaaccctgg ccct atg tac aga atg cag ctg ctg ctg ctg atc gcc ctg       3546
                Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu           
                    460                 465                 470           

agc ctg gcc ctg gtg acc aac agc gat atc gtc atg acc cag agc cca       3594
Ser Leu Ala Leu Val Thr Asn Ser Asp Ile Val Met Thr Gln Ser Pro           
                475                 480                 485               

gat agc ctg gcc gtg agc ctg gga gag cgg gcc acc atc aac tgc aag       3642
Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys           
            490                 495                 500                   

agc agc cag agc gtg ctg tac agc agc aac aac aag aac tac ctg gcc       3690
Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala           
        505                 510                 515                       

tgg tac cag cag aag cca gga cag cca cca aag ctg ctg atc tac tgg       3738
Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp           
    520                 525                 530                           

gcc agc acc cgg gag agc gga gtg cca gat cgg ttc agc gga agc gga       3786
Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly           
535                 540                 545                 550           

agc gga acc gat ttc acc ctg acc atc agc agc ctg cag gcc gag gat       3834
Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp           
                555                 560                 565               

gtg gcc gtg tac tac tgc cag cag tac tac agc acc cca ctg acc ttc       3882
Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Leu Thr Phe           
            570                 575                 580                   

gga cag gga acc aag gtg gag atc aag cgt acg gtg gcc gcc cca agc       3930
Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser           
        585                 590                 595                       

gtg ttc atc ttc cca cca agc gat gag cag ctg aag agc gga acc gcc       3978
Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala           
    600                 605                 610                           

agc gtg gtg tgc ctg ctg aac aac ttc tac cca cgg gag gcc aag gtg       4026
Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val           
615                 620                 625                 630           

cag tgg aag gtg gat aac gcc ctg cag agc gga aac agc cag gag agc       4074
Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser           
                635                 640                 645               

gtg acc gag cag gat agc aag gat agc acc tac agc ctg agc agc acc       4122
Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr           
            650                 655                 660                   

ctg acc ctg agc aag gcc gat tac gag aag cac aag gtg tac gcc tgc       4170
Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys           
        665                 670                 675                       

gag gtg acc cac cag gga ctg agc agc cca gtg acc aag agc ttc aac       4218
Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn           
    680                 685                 690                           

cgc gga gag tgc tgataaagcg gccgcggtac ctctagagtc gacccgggcg           4270
Arg Gly Glu Cys                                                           
695                                                                       

gcctcgagga cggggtgaac tacgcctgag gatccgatct ttttccctct gccaaaaatt     4330

atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg aaatttattt     4390

tcattgcaat agtgtgttgg aattttttgt gtctctcact cggaagcaat tcgttgatct     4450

gaatttcgac cacccataat acccattacc ctggtagata agtagcatgg cgggttaatc     4510

attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4570

ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca     4630

gtgagcgagc gagcgcgcag ccttaattaa cctaattcac tggccgtcgt tttacaacgt     4690

cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca tccccctttc     4750

gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc     4810

ctgaatggcg aatgggacgc gccctgtagc ggcgcattaa gcgcggcggg tgtggtggtt     4870

acgcgcagcg tgaccgctac acttgccagc gccctagcgc ccgctccttt cgctttcttc     4930

ccttcctttc tcgccacgtt cgccggcttt ccccgtcaag ctctaaatcg ggggctccct     4990

ttagggttcc gatttagtgc tttacggcac ctcgacccca aaaaacttga ttagggtgat     5050

ggttcacgta gtgggccatc gccctgatag acggtttttc gccctttgac gttggagtcc     5110

acgttcttta atagtggact cttgttccaa actggaacaa cactcaaccc tatctcggtc     5170

tattcttttg atttataagg gattttgccg atttcggcct attggttaaa aaatgagctg     5230

atttaacaaa aatttaacgc gaattttaac aaaatcatgt gagcaaaagg ccagcaaaag     5290

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     5350

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     5410

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     5470

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     5530

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     5590

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     5650

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     5710

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     5770

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     5830

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     5890

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     5950

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     6010

acctagatcc ttttgatcct ccggcgttca gcctgtgcca cagccgacag gatggtgacc     6070

accatttgcc ccatatcacc gtcggtactg atcccgtcgt caataaaccg aaccgctaca     6130

ccctgagcat caaactcttt tatcagttgg atcatgtcgg cggtgtcgcg gccaagacgg     6190

tcgagcttct tcaccagaat gacatcacct tcctccacct tcatcctcag caaatccagc     6250

ccttcccgat ctgttgaact gccggatgcc ttgtcggtaa agatgcggtt agcttttacc     6310

cctgcatctt tgagcgctga ggtctgcctc gtgaagaagg tgttgctgac tcataccagg     6370

cctgaatcgc cccatcatcc agccagaaag tgagggagcc acggttgatg agagctttgt     6430

tgtaggtgga ccagttggtg attttgaact tttgctttgc cacggaacgg tctgcgttgt     6490

cgggaagatg cgtgatctga tccttcaact cagcaaaagt tcgatttatt caacaaagcc     6550

gccgtcccgt caagtcagcg taatgctctg ccagtgttac aaccaattaa ccaattctga     6610

ttagaaaaac tcatcgagca tcaaatgaaa ctgcaattta ttcatatcag gattatcaat     6670

accatatttt tgaaaaagcc gtttctgtaa tgaaggagaa aactcaccga ggcagttcca     6730

taggatggca agatcctggt atcggtctgc gattccgact cgtccaacat caatacaacc     6790

tattaatttc ccctcgtcaa aaataaggtt atcaagtgag aaatcaccat gagtgacgac     6850

tgaatccggt gagaatggca aaagcttatg catttctttc cagacttgtt caacaggcca     6910

gccattacgc tcgtcatcaa aatcactcgc atcaaccaaa ccgttattca ttcgtgattg     6970

cgcctgagcg agacgaaata cgcgatcgct gttaaaagga caattacaaa caggaatcga     7030

atgcaaccgg cgcaggaaca ctgccagcgc atcaacaata ttttcacctg aatcaggata     7090

ttcttctaat acctggaatg ctgttttccc ggggatcgca gtggtgagta accatgcatc     7150

atcaggagta cggataaaat gcttgatggt cggaagaggc ataaattccg tcagccagtt     7210

tagtctgacc atctcatctg taacatcatt ggcaacgcta cctttgccat gtttcagaaa     7270

caactctggc gcatcgggct tcccatacaa tcgatagatt gtcgcacctg attgcccgac     7330

attatcgcga gcccatttat acccatataa atcagcatcc atgttggaat ttaatcgcgg     7390

cctcgagcaa gacgtttccc gttgaatatg gctcataaca ccccttgtat tactgtttat     7450

gtaagcagac agttttattg ttcatgatga tatattttta tcttgtgcaa tgtaacatca     7510

gagattttga gacaccatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat     7570

taccgccttt gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc     7630

agtgagcgag gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc     7690

gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa     7750

cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc     7810

ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga     7870

ccatgattac gccagattta attaaggcct taattagg                             7908


<210>  2
<211>  129
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Ala Asn Tyr Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Ser Gln Leu Arg Ser Leu Leu Tyr Phe Glu Trp Leu Ser 
            100                 105                 110         


Gln Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  3
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  3

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
            100                 105         


<210>  4
<211>  222
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Glu Pro Asp 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         


<210>  5
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  6
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  7

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  8
<211>  7899
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CIs plasmid containing CR8033 heavy chain and light chain from 
       kappa germline


<220>
<221>  misc_feature
<222>  (264)..(287)
<223>  CMV promoter end

<220>
<221>  promoter
<222>  (285)..(565)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (288)..(318)
<223>  begin promoter

<220>
<221>  TATA_signal
<222>  (539)..(542)

<220>
<221>  Intron
<222>  (659)..(1631)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1517)..(1533)
<223>  end of intron

<220>
<221>  misc_feature
<222>  (1643)..(1690)
<223>  c-myc 5' UTR

<220>
<221>  misc_feature
<222>  (1691)..(1698)
<223>  kozak

<220>
<221>  CDS
<222>  (1753)..(2133)
<223>  CR8033cc variable heavy

<220>
<221>  CDS
<222>  (2134)..(2454)
<223>  CH1

<220>
<221>  CDS
<222>  (2455)..(3120)
<223>  CH2-3

<220>
<221>  misc_feature
<222>  (3121)..(3132)
<223>  furin cleavage site

<220>
<221>  misc_feature
<222>  (3133)..(3204)
<223>  F2A linker

<220>
<221>  CDS
<222>  (3265)..(3603)
<223>  Kappa germline light

<220>
<221>  CDS
<222>  (3604)..(3924)
<223>  constant light

<220>
<221>  polyA_signal
<222>  (4000)..(4126)

<220>
<221>  repeat_region
<222>  (4215)..(4344)
<223>  3' ITR (on complement)

<220>
<221>  misc_feature
<222>  (4521)..(4959)
<223>  F1 ori on complementary strand

<220>
<221>  misc_feature
<222>  (4988)..(5630)
<223>  pUC origin of replication

<220>
<221>  misc_feature
<222>  (7363)..(7548)
<223>  Lac promoter

<220>
<221>  repeat_region
<222>  (7603)..(7732)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (7806)..(7835)
<223>  promoter start

<400>  8
aaatggcccg cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta       60

tgttcccata gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg      120

gtaaactgcc cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga      180

cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt      240

tcctacttgg cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc      300

cacgttctgc ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt      360

tattttttaa ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg      420

cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa      480

tcagagcggc gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta      540

taaaaagcga agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg      600

ctccgccgcc gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt      660

gagcgggcgg gacggccctt ctcctccggg ctgtaattag cgcttggttt aatgacggct      720

tgtttctttt ctgtggctgc gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg      780

ggggagcggc tcggggggtg cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc      840

cgcgctgccc ggcggctgtg agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag      900

tgtgcgcgag gggagcgcgg ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg      960

gaacaaaggc tgcgtgcggg gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc     1020

ggtcgggctg caaccccccc tgcacccccc tccccgagtt gctgagcacg gcccggcttc     1080

gggtgcgggg ctccgtacgg ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg     1140

gcaggtgggg gtgccgggcg gggcggggcc gcctcgggcc ggggagggct cgggggaggg     1200

gcgcggcggc ccccggagcg ccggcggctg tcgaggcgcg gcgagccgca gccattgcct     1260

tttatggtaa tcgtgcgaga gggcgcaggg acttcctttg tcccaaatct gtgcggagcc     1320

gaaatctggg aggcgccgcc gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc     1380

cggcaggaag gaaatgggcg gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct     1440

ccctctccag cctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag     1500

ggcggggttc ggcttctggc gtgtgaccgg cggctctaga gcctctgcta accatgttca     1560

tgccttcttc tttttcctac agctcctggg caacgtgctg gttattgtgc tgtctcatca     1620

ttttggcaaa gaattcgcta gcgggcactt tgcactggaa cttacaacac ccgagcaagg     1680

acgcgactct ccaccatgcg catgcagctg ctgctgctga tcgccctgag cctggccctg     1740

gtgaccaaca gc gag gtg cag ctg gtg gag acc gga gga gga ctg gtg cag     1791
              Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln         
              1               5                   10                      

cca gga cgg agc ctg cgg ctg agc tgc gcc gcc agc gga ttc agc ttc       1839
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe           
    15                  20                  25                            

gat gag tac acc atg cac tgg gtg cgg cag gcc cca gga aag gga ctg       1887
Asp Glu Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu           
30                  35                  40                  45            

gag tgg gtg gcc gga atc aac tgg aag gga aac ttc atg gga tac gcc       1935
Glu Trp Val Ala Gly Ile Asn Trp Lys Gly Asn Phe Met Gly Tyr Ala           
                50                  55                  60                

gat agc gtg cag gga cgg ttc acc atc agc cgg gat aac gga aag aac       1983
Asp Ser Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn           
            65                  70                  75                    

agc ctg tac ctg cag atg aac agc ctg cgg gcc gag gat acc gcc ctg       2031
Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu           
        80                  85                  90                        

tac tac tgc gcc aag gat cgg ctg gag agc agc gcc atg gat atc ctg       2079
Tyr Tyr Cys Ala Lys Asp Arg Leu Glu Ser Ser Ala Met Asp Ile Leu           
    95                  100                 105                           

gag gga gga acc ttc gat atc tgg gga cag gga acc atg gtg acc gtg       2127
Glu Gly Gly Thr Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val           
110                 115                 120                 125           

agc agc gcg tcg acc aag gga cct tcg gtc ttc ccc ctg gca ccc tcc       2175
Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser           
                130                 135                 140               

tcc aag agc acc tct ggg ggc aca gcg gcc ctg ggc tgc ctg gtc aag       2223
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys           
            145                 150                 155                   

gac tac ttc ccc gaa ccg gtg acg gtg tcg tgg aac tca ggc gcc ctg       2271
Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu           
        160                 165                 170                       

acc agc ggc gtg cac acc ttc ccg gct gtc cta cag tcc tca gga ctc       2319
Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu           
    175                 180                 185                           

tac tcc ctc agc agc gtg gtg acc gtg ccc tcc agc agc ttg ggc acc       2367
Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr           
190                 195                 200                 205           

cag acc tac atc tgc aac gtg aat cac aag ccc agc aac acc aag gtg       2415
Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val           
                210                 215                 220               

gac aag aaa gtt gaa cca aag agc tgc gac aag acc cac acg tgt ccc       2463
Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro           
            225                 230                 235                   

ccc tgc cct gcc cct gaa ctg ctg gga ggc ccc agc gtg ttc ctg ttc       2511
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe           
        240                 245                 250                       

ccc cca aag ccc aag gac acc ctg atg atc agc cgg acc ccc gaa gtg       2559
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val           
    255                 260                 265                           

acc tgc gtg gtg gtg gac gtg tcc cac gag gac cct gaa gtg aag ttt       2607
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe           
270                 275                 280                 285           

aat tgg tac gtg gac ggc gtg gaa gtg cac aac gcc aag acc aag ccc       2655
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro           
                290                 295                 300               

aga gag gaa cag tac aac agc acc tac cgg gtg gtg tcc gtg ctg acc       2703
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr           
            305                 310                 315                   

gtg ctg cac cag gac tgg ctg aac ggc aaa gag tac aag tgc aag gtg       2751
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val           
        320                 325                 330                       

tcc aac aag gcc ctg cct gcc ccc atc gag aaa acc atc agc aag gcc       2799
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala           
    335                 340                 345                           

aag ggc cag ccc cgc gag cct cag gtc tac aca ctg ccc ccc agc cgg       2847
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg           
350                 355                 360                 365           

gaa gag atg acc aag aac cag gtg tcc ctg acc tgc ctg gtc aag ggc       2895
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly           
                370                 375                 380               

ttc tac ccc agc gac atc gcc gtg gaa tgg gag agc aac ggc cag ccc       2943
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro           
            385                 390                 395                   

gag aac aac tac aag acc acc ccc cct gtg ctg gac agc gac ggc tca       2991
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser           
        400                 405                 410                       

ttc ttc ctg tat agc aag ctg acc gtg gac aag agc cgg tgg cag cag       3039
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln           
    415                 420                 425                           

ggc aac gtg ttc agc tgc agc gtg atg cac gag gcc ctg cac aac cac       3087
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His           
430                 435                 440                 445           

tac acc cag aag tcc ctg agc ctg agc ccc ggc agaaagcgga gagcccccgt     3140
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly                               
                450                 455                                   

gaagcagacc ctgaacttcg acctgctgaa gctggccggc gacgtggaaa gcaaccctgg     3200

ccctatgtac agaatgcagc tgctgctgct gatcgccctg agcctggccc tggtgaccaa     3260

cagc gat atc gtc atg acc cag agc cca gat agc ctg gcc gtg agc ctg      3309
     Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu          
                 460                 465                 470              

gga gag cgg gcc acc atc aac tgc aag agc agc cag agc gtg ctg tac       3357
Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr           
            475                 480                 485                   

agc agc aac aac aag aac tac ctg gcc tgg tac cag cag aag cca gga       3405
Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly           
        490                 495                 500                       

cag cca cca aag ctg ctg atc tac tgg gcc agc acc cgg gag agc gga       3453
Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly           
    505                 510                 515                           

gtg cca gat cgg ttc agc gga agc gga agc gga acc gat ttc acc ctg       3501
Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu           
520                 525                 530                 535           

acc atc agc agc ctg cag gcc gag gat gtg gcc gtg tac tac tgc cag       3549
Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln           
                540                 545                 550               

cag tac tac agc acc cca ctg acc ttc gga cag gga acc aag gtg gag       3597
Gln Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu           
            555                 560                 565                   

atc aag cgt acg gtg gcc gcc cca agc gtg ttc atc ttc cca cca agc       3645
Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser           
        570                 575                 580                       

gat gag cag ctg aag agc gga acc gcc agc gtg gtg tgc ctg ctg aac       3693
Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn           
    585                 590                 595                           

aac ttc tac cca cgg gag gcc aag gtg cag tgg aag gtg gat aac gcc       3741
Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala           
600                 605                 610                 615           

ctg cag agc gga aac agc cag gag agc gtg acc gag cag gat agc aag       3789
Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys           
                620                 625                 630               

gat agc acc tac agc ctg agc agc acc ctg acc ctg agc aag gcc gat       3837
Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp           
            635                 640                 645                   

tac gag aag cac aag gtg tac gcc tgc gag gtg acc cac cag gga ctg       3885
Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu           
        650                 655                 660                       

agc agc cca gtg acc aag agc ttc aac cgc gga gag tgc tgataaagcg        3934
Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                       
    665                 670                 675                           

gccgcggtac ctctagagtc gacccgggcg gcctcgagga cggggtgaac tacgcctgag     3994

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4054

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4114

gtctctcact cggaagcaat tcgttgatct gaatttcgac cacccataat acccattacc     4174

ctggtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     4234

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     4294

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ccttaattaa     4354

cctaattcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg cgttacccaa     4414

cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga agaggcccgc     4474

accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgggacgc gccctgtagc     4534

ggcgcattaa gcgcggcggg tgtggtggtt acgcgcagcg tgaccgctac acttgccagc     4594

gccctagcgc ccgctccttt cgctttcttc ccttcctttc tcgccacgtt cgccggcttt     4654

ccccgtcaag ctctaaatcg ggggctccct ttagggttcc gatttagtgc tttacggcac     4714

ctcgacccca aaaaacttga ttagggtgat ggttcacgta gtgggccatc gccctgatag     4774

acggtttttc gccctttgac gttggagtcc acgttcttta atagtggact cttgttccaa     4834

actggaacaa cactcaaccc tatctcggtc tattcttttg atttataagg gattttgccg     4894

atttcggcct attggttaaa aaatgagctg atttaacaaa aatttaacgc gaattttaac     4954

aaaatcatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg     5014

gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg ctcaagtcag     5074

aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg aagctccctc     5134

gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt tctcccttcg     5194

ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt     5254

cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc     5314

ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact ggcagcagcc     5374

actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg     5434

tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct gctgaagcca     5494

gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac cgctggtagc     5554

ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat     5614

cctttgatct tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt     5674

ttggtcatga gattatcaaa aaggatcttc acctagatcc ttttgatcct ccggcgttca     5734

gcctgtgcca cagccgacag gatggtgacc accatttgcc ccatatcacc gtcggtactg     5794

atcccgtcgt caataaaccg aaccgctaca ccctgagcat caaactcttt tatcagttgg     5854

atcatgtcgg cggtgtcgcg gccaagacgg tcgagcttct tcaccagaat gacatcacct     5914

tcctccacct tcatcctcag caaatccagc ccttcccgat ctgttgaact gccggatgcc     5974

ttgtcggtaa agatgcggtt agcttttacc cctgcatctt tgagcgctga ggtctgcctc     6034

gtgaagaagg tgttgctgac tcataccagg cctgaatcgc cccatcatcc agccagaaag     6094

tgagggagcc acggttgatg agagctttgt tgtaggtgga ccagttggtg attttgaact     6154

tttgctttgc cacggaacgg tctgcgttgt cgggaagatg cgtgatctga tccttcaact     6214

cagcaaaagt tcgatttatt caacaaagcc gccgtcccgt caagtcagcg taatgctctg     6274

ccagtgttac aaccaattaa ccaattctga ttagaaaaac tcatcgagca tcaaatgaaa     6334

ctgcaattta ttcatatcag gattatcaat accatatttt tgaaaaagcc gtttctgtaa     6394

tgaaggagaa aactcaccga ggcagttcca taggatggca agatcctggt atcggtctgc     6454

gattccgact cgtccaacat caatacaacc tattaatttc ccctcgtcaa aaataaggtt     6514

atcaagtgag aaatcaccat gagtgacgac tgaatccggt gagaatggca aaagcttatg     6574

catttctttc cagacttgtt caacaggcca gccattacgc tcgtcatcaa aatcactcgc     6634

atcaaccaaa ccgttattca ttcgtgattg cgcctgagcg agacgaaata cgcgatcgct     6694

gttaaaagga caattacaaa caggaatcga atgcaaccgg cgcaggaaca ctgccagcgc     6754

atcaacaata ttttcacctg aatcaggata ttcttctaat acctggaatg ctgttttccc     6814

ggggatcgca gtggtgagta accatgcatc atcaggagta cggataaaat gcttgatggt     6874

cggaagaggc ataaattccg tcagccagtt tagtctgacc atctcatctg taacatcatt     6934

ggcaacgcta cctttgccat gtttcagaaa caactctggc gcatcgggct tcccatacaa     6994

tcgatagatt gtcgcacctg attgcccgac attatcgcga gcccatttat acccatataa     7054

atcagcatcc atgttggaat ttaatcgcgg cctcgagcaa gacgtttccc gttgaatatg     7114

gctcataaca ccccttgtat tactgtttat gtaagcagac agttttattg ttcatgatga     7174

tatattttta tcttgtgcaa tgtaacatca gagattttga gacaccatgt tctttcctgc     7234

gttatcccct gattctgtgg ataaccgtat taccgccttt gagtgagctg ataccgctcg     7294

ccgcagccga acgaccgagc gcagcgagtc agtgagcgag gaagcggaag agcgcccaat     7354

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     7414

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     7474

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     7534

ataacaattt cacacaggaa acagctatga ccatgattac gccagattta attaaggcct     7594

taattaggct gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg     7654

cgacctttgg tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact     7714

ccatcactag gggttccttg tagttaatga ttaacccgcc atgctactta tctaccaggg     7774

taatggggat cctctagaac tatagctagt cgacattgat tattgactag ttattaatag     7834

taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt     7894

acggt                                                                 7899


<210>  9
<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  9

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asp Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Asn Trp Lys Gly Asn Phe Met Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Gly Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Leu Glu Ser Ser Ala Met Asp Ile Leu Glu Gly Gly 
            100                 105                 110         


Thr Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  10
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  10

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
            100                 105         


<210>  11
<211>  222
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  11

Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         


<210>  12
<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  13
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  13

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  14
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  include leader-entire heavy chain-furin-F2A linker-leader-entire 
       light chain

<400>  14
atgtatagaa tgcagttgtt gtcgtgcatc gcactctctc tcgcgcttgt cacaaactcc       60

caggttcaac tggtggagtc aggggggggg gtggtgcagc cggggcggag tctgaggctg      120

agctgcgccg cgagtggatt cacgttttcg acatacgcga tgcactgggt ccgccaggcc      180

cccggaaagg gtctggaatg ggtggccgtg attagttacg atgcgaatta caagtattac      240

gccgactcag tgaagggccg gttcacgata tcacgggaca actctaaaaa caccctgtac      300

cttcaaatga actcactgcg ggcggaggat accgctgtct actattgtgc aaaggactct      360

cagctgcgat ccttgctgta tttcgagtgg ctgagccagg gttactttga ctactgggga      420

cagggcaccc tcgtgaccgt gtcctctgcc tcaacgaagg ggccgtccgt ttttccactg      480

gctccgtcaa gcaaatcaac tagcggcggg actgcagcat tggggtgcct agtgaaggac      540

tatttccccg agcctgtgac ggtgtcgtgg aactcgggag cactgacgtc cggggtgcac      600

acattccccg cggtgctgca gagctccggg ctgtattcgt tgagcagtgt cgtgactgtg      660

cccagctcga gtctggggac tcagacatac atctgcaacg tgaaccataa gccatctaat      720

acgaaggtgg acaagaaggt cgagccaaag tcgtgcgaca agacccatac atgcccacca      780

tgtcccgcgc cggagctgtt gggcgggccc tcagtgttcc tgttcccgcc taagccaaag      840

gacacgctga tgattagccg gacccctgaa gtgacatgcg tggtggtgga tgtatcccac      900

gaggaacccg acgtgaagtt caattggtac gtggacgggg tggaggtgca caatgctaaa      960

accaaacccc gggaggagca gtacaactct acgtaccggg tggtgtccgt actgaccgtg     1020

ctacaccagg actggctgaa cgggaaggag tacaagtgta aagtgtcgaa caaggctctg     1080

ccagccccca ttgagaaaac catatcaaag gctaagggcc agcccaggga gcctcaagtg     1140

tacacgctgc cgccgagccg cgacgagctg acaaagaacc aggtttcgct gacgtgcctt     1200

gtcaagggat tctacccaag cgacatcgca gtggagtggg agtctaacgg acagccagag     1260

aacaactaca aaaccacgcc gcccgtgctg gattcggacg gctccttctt tctgtactct     1320

aagctgacgg tggacaagtc cagatggcag caggggaacg tattcagctg cagtgtgatg     1380

cacgaggcct tgcacaatca ctatacgcag aagagtctgt ccttgtcacc gggaaggaag     1440

cgcagggccc ctgtgaagca gacactgaac ttcgacttac tgaagttggc cggcgacgtg     1500

gagtcgaacc ctgggccgat gtaccggatg cagctcctgc tcctgatcgc gctgtcgctg     1560

gctttggtta ccaactccga cattgtgatg acgcaaagcc ctgactccct ggcggtgtct     1620

ctgggggaga gggccactat caactgcaaa tccagccaga gcgtgctgta ctcgtcaaac     1680

aacaagaatt acttagcctg gtaccagcag aagccaggac agccgccaaa gttgctgatc     1740

tattgggcct ctacgcggga gtcgggagtg ccagataggt tcagcgggag tgggagcggt     1800

acagacttca ccctgaccat aagcagcttg caggcggagg atgtggcagt gtactactgc     1860

cagcagtact actcgacacc cttgacattc ggccagggga ccaaagtgga gatcaagcgt     1920

accgtagccg ccccgagcgt gttcatcttt ccaccgtccg acgaacagct gaagtcgggg     1980

accgccagcg tcgtgtgttt gctgaacaac ttctaccccc gggaagcaaa ggtccagtgg     2040

aaggtcgaca acgcattgca gtcggggaac tcccaggaaa gcgtgactga gcaggattcc     2100

aaggacagta catactcact gtcgtcaact ctcacactgt ccaaggcgga ctacgagaag     2160

cacaaggtgt acgcctgcga ggttacgcac caggggctgt cctctcccgt gacgaaaagc     2220

ttcaataggg gggagtgc                                                   2238


<210>  15
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  lF16 11 eader-entire heavy chain-furin-F2A linker-leader-entire 
       light chain

<400>  15
atgtatagaa tgcaactgct ctcctgtatc gcattgtctc tggctctcgt gacgaattcc       60

caagtgcaat tggtggagtc tgggggcggc gttgtgcagc ccgggcggag cctcaggttg      120

tcgtgtgctg ccagcggctt tacgttttca acctatgcca tgcattgggt tcgacaggca      180

cccggcaaag gcctggaatg ggtcgccgtg attagctatg acgctaacta caagtattat      240

gctgattccg tgaagggccg ctttacaatc agtcgcgata attccaagaa caccctgtat      300

ctgcaaatga acagcctgag ggctgaggac acagccgtgt attactgtgc aaaggacagc      360

cagttgcgga gcctcctgta tttcgagtgg ctgagccagg gctattttga ttattggggc      420

cagggcactc tggtcaccgt tagctctgct agtaccaaag gcccaagcgt ctttccactc      480

gctccatcgt ccaagtctac ctctggggga accgctgctc tgggctgcct agtgaaagac      540

tatttccccg aaccggttac agtctcctgg aattctggcg cgctgacgag cggtgtacat      600

acttttccgg cggtgctcca gtcctccggc ctgtatagtc tgagttccgt agtcaccgta      660

ccatcatcta gtctgggaac ccaaacatat atttgcaacg tgaaccataa gccttccaac      720

actaaggtcg ataagaaggt tgaacccaaa agctgtgaca agacccacac atgtcctcct      780

tgtcccgcac cggagttgtt gggcggccct tccgtgtttc tgtttccgcc caagcctaag      840

gatacactga tgattagcag aaccccagaa gtcacttgcg tggtggtgga tgtgtcccat      900

gaggaaccag acgtgaagtt taattggtat gtagacgggg tggaggtaca caacgcaaag      960

accaagccga gggaggagca gtacaacagc acctatcgcg tggtgtcagt gttaacggta     1020

ctgcaccaag actggctgaa tgggaaggag tataagtgta aagtgtcaaa caaggctctg     1080

ccagctccaa tagaaaagac tattagcaag gctaagggcc agccgaggga accccaggtc     1140

tacaccctgc cgccgagccg cgacgaactg accaaaaacc aggtttccct gacatgtctg     1200

gtcaagggtt tctacccttc cgacatcgct gtagaatggg agtccaatgg tcaaccggaa     1260

aacaactata agactacgcc ccctgtactg gacagcgacg gcagtttctt cttgtattca     1320

aagcttacag ttgacaagtc aagatggcag cagggcaatg tctttagctg ttccgtgatg     1380

catgaggctt tacataacca ctacactcaa aagagtctgt cgttgtctcc tggccggaag     1440

agaagggcac cagttaagca gaccctgaac tttgaccttc tcaagttggc tggcgatgtg     1500

gaaagcaacc ccggcccaat gtaccggatg cagctgctgc ttctgattgc cctgtcactg     1560

gctctagtta ccaactccga tatagtgatg actcagtctc ccgattccct ggctgtatct     1620

ttgggagagc gagccacgat caattgcaaa tccagccaaa gcgtgctgta tagctctaac     1680

aacaagaatt atctggcttg gtaccagcaa aaacctggcc aacccccaaa gctgttgatc     1740

tattgggctt ccacccgtga atccggcgtg cccgaccggt ttagcggttc cggctctgga     1800

accgatttta ctctgacaat ttccagcctg caagctgaag atgtggccgt ctactattgt     1860

caacagtatt actctacacc actaacattt gggcagggca cgaaagtaga gattaagagg     1920

actgtggctg ccccatccgt gtttatcttt cctccctccg acgagcagct gaagagtggc     1980

acggctagtg ttgtttgtct gttgaacaat ttctatcccc gggaggccaa ggttcagtgg     2040

aaagtagaca acgcattgca gtccgggaat agccaggaga gtgtgacaga acaggactct     2100

aaggacagca cttattccct gtcgagcacc ctgaccttga gcaaggccga ctacgaaaag     2160

cataaggtct acgcctgcga agtgacacat cagggcctga gttcacccgt gacaaagagc     2220

tttaacaggg gcgaatgt                                                   2238


<210>  16
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 26

<400>  16
atgtaccgca tgcagctctt atcgtgtatt gccctgagtc ttgccctcgt gacaaatagc       60

caggtccagc tcgtggaatc tggcggtggc gtggtgcagc ccggaagaag cttaaggctg      120

tcatgcgccg ccagcggctt tacgtttagt acttatgcaa tgcactgggt ccgacaggct      180

cccgggaagg gcttggaatg ggtggccgtg attagctacg acgctaacta caagtattac      240

gccgactctg tcaagggaag attcacgatc tctcgtgaca attcaaagaa taccttgtac      300

cttcaaatga acagcctgcg ggctgaagat accgccgtat actactgcgc taaggactca      360

cagctgcgct ctcttctcta cttcgaatgg ctaagccagg gttactttga ctactgggga      420

caggggaccc ttgttaccgt gtctagtgcc agcaccaagg gtcccagcgt gttccccctg      480

gctccaagct ctaaatcaac ctcgggtggt actgcagcac taggctgcct tgtgaaggac      540

tacttccccg agccagtaac cgtgtcctgg aattctggtg ctctaacctc cggagtgcat      600

accttccctg ctgtgttgca gtcaagcggg ctgtacagtc tgtcaagtgt cgtgaccgtg      660

ccttcatctt ccctcggaac tcagacctac atatgtaacg tgaatcacaa gccgtccaat      720

accaaagtgg acaaaaaggt cgaacccaag tcgtgcgaca agacccatac gtgcccacca      780

tgccccgctc ccgagctatt gggtggacct tcagtgttct tattccctcc aaaacccaag      840

gataccttga tgatttcacg gacccctgaa gtgacctgtg tggtggttga cgtgtcacat      900

gaggaacccg atgtgaagtt taattggtat gtggacggcg tggaggttca taacgctaaa      960

accaagccca gggaagaaca gtacaacagt acttaccgcg tggtgtctgt gcttaccgtg     1020

ctgcatcagg actggctgaa tggaaaggag tacaagtgca aggtgtccaa taaggctttg     1080

cccgcgccta tcgaaaagac catatctaag gccaagggcc agccccgaga gcctcaggtc     1140

tacacactcc ctccatcccg cgacgagctg acaaagaatc aagtgtctct cacctgtctt     1200

gtgaagggtt tctatccctc tgacatcgcc gtggagtggg agtcgaacgg ccagcccgaa     1260

aacaactaca agaccacccc tcccgtgctg gactcagacg gttcgttctt tctgtattcc     1320

aagctgaccg tcgacaaaag cagatggcag caggggaacg tcttttcatg ctccgtgatg     1380

cacgaagcac tgcacaatca ctatacccag aaatcactgt ctctgtctcc tggtcggaaa     1440

cgcagggcgc ctgtgaagca gactctcaat ttcgaccttc ttaagctcgc tggagatgtg     1500

gagagcaacc ccgggccaat gtacaggatg cagcttctac tgctgatcgc actgtctctc     1560

gcactcgtga cgaattccga catagtgatg acccagtccc ctgactcact cgctgtgtcc     1620

ctcggtgaac gcgccaccat caactgcaag agttcacagt cagtgttata cagttctaac     1680

aataagaatt acctggcctg gtaccaacag aagcccggtc aaccgcccaa gttacttatc     1740

tattgggcct ccacccgtga aagcggagtg cccgacaggt ttagcggtag tggtagtggt     1800

accgacttta ccctgactat cagtagccta caggcagagg atgtggcggt gtactactgc     1860

cagcagtact actcaactcc attgacattc ggccagggta ccaaagtcga gatcaagcgc     1920

actgtggccg ccccgagcgt gtttattttt ccaccgtctg atgagcagct taagtcaggc     1980

accgctagtg tagtgtgcct gctgaacaac ttttatcctc gggaggccaa agtgcagtgg     2040

aaggtcgaca acgcacttca gagtggcaat agtcaggaat ccgtgacaga acaggattca     2100

aaggactcaa cctactcttt gagttcaacc cttaccctgt cgaaggcaga ctacgagaag     2160

cacaaggttt acgcctgcga agtgacccat cagggcctca gcagccccgt aaccaagtcc     2220

tttaatcggg gggaatgc                                                   2238


<210>  17
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 28

<400>  17
atgtaccgaa tgcagcttct ttcatgtatc gcactttccc ttgcccttgt tacaaatagt       60

caagtgcagt tggtggagag cggcggcggc gtagtgcagc ccggccgatc tctccgacta      120

tcctgtgccg cgagcggctt taccttctca acctatgcta tgcattgggt cagacaggcc      180

cctggaaagg gtcttgaatg ggtggccgtg atttcctatg acgctaacta caagtattac      240

gcagactctg tgaagggccg tttcacaatt agcagggaca attccaagaa tactctttat      300

ctgcaaatga atagcttaag agccgaggac accgctgtgt actattgtgc aaaggatagt      360

cagctgagga gcctactcta cttcgagtgg ttgagccagg gctattttga ttattggggc      420

cagggcaccc ttgtgaccgt gtcaagtgcc agtaccaagg gcccttccgt gttccctctc      480

gcaccctcat ctaagtcaac tagtggcggc acggctgccc ttggttgtct cgtgaaggac      540

tatttccctg agcctgtcac tgtgtcctgg aattctggcg cacttacctc tggcgtgcat      600

accttccccg cggtgcttca gagtagtggt ctttattctc tgagtagcgt ggtcaccgtg      660

cctagttcta gtttgggtac tcagacttat atttgtaacg tgaaccacaa gcccagcaac      720

acaaaagtgg acaagaaggt cgaacctaaa tcttgcgata agacccacac atgccctcct      780

tgccctgcac ctgagctact gggcggtcct agcgtgttcc tttttccacc caagccaaag      840

gacaccctga tgatatcccg gacgccagaa gttacatgcg tggtggtgga cgtatctcat      900

gaggagcctg atgtgaagtt caattggtac gtggacggcg tggaggtgca caatgctaag      960

acaaagccta gagaggagca gtacaatagc acctatagag tggtttcagt gcttactgtg     1020

ctgcaccagg actggcttaa tgggaaggag tataagtgca aagtctccaa taaggctctg     1080

cccgcaccca tcgaaaagac aattagcaaa gccaagggcc agcctcgaga gcctcaggtc     1140

tatacactgc cacctagccg ggacgagctg actaagaatc aggtttcgct cacgtgtcta     1200

gtgaagggct tttacccttc cgacattgct gtggagtggg agtctaatgg ccagcccgag     1260

aacaattaca agaccacgcc accggtgttg gactctgacg ggagcttctt cctatactct     1320

aagcttactg tggacaagtc gagatggcag cagggaaacg tgttctcctg ttctgtgatg     1380

catgaggccc tgcacaacca ttatacccag aagtcgctct ccctgagccc tggcagaaaa     1440

agacgcgcgc ctgtgaagca gacacttaac tttgatcttc tgaagctcgc cggcgacgtc     1500

gagagtaatc ctggcccaat gtataggatg cagctgttac ttctgatcgc cttatctctt     1560

gctcttgtga cgaactcaga catagtgatg actcagtccc ccgattctct tgccgtgtct     1620

ctcggggagc gggccacgat caattgcaaa tcaagtcaat cagtgctgta ctctagtaac     1680

aataagaact acctagcctg gtatcagcaa aagcctggcc agcctcctaa gctccttatc     1740

tattgggcgt ctaccagaga gtccggagtg cccgatagat tcagcggatc agggtctggg     1800

accgatttta ccctcacaat tagtagcctt caggcggagg acgtggccgt gtattactgc     1860

cagcagtact actccacgcc tctgacattt gggcagggca ccaaggtcga gatcaaaaga     1920

acagtagcag ccccgtcagt gttcattttt cctccatctg acgaacagct caaaagcggg     1980

actgcgtccg tagtgtgctt gctcaacaac ttttacccac gagaggccaa ggtccagtgg     2040

aaagtggata atgcacttca gagcggcaac agtcaggagt ccgtgacgga gcaggattct     2100

aaggactcca catatagtct cagtagtact ttaacgttgt cgaaggccga ttacgagaag     2160

cataaagtgt acgcttgtga agtgacccac cagggcttat caagccctgt gacaaagtcc     2220

ttcaatcgcg gggagtgt                                                   2238


<210>  18
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 30 cDNA

<400>  18
atgtatagaa tgcaactcct gtcatgtatc gcactgtctc tcgcactcgt cacaaacagc       60

caggtccagc tagtggagtc cggggggggt gtagtgcaac ctgggagatc attaaggctg      120

agctgtgccg cttctgggtt cacattttca acatacgcta tgcactgggt ccgtcaggca      180

cctggaaaag gattggaatg ggtggctgtg atctcctatg acgctaacta taagtattat      240

gccgatagcg tgaaggggcg gtttactatc tcgagagata actccaagaa cacgctttat      300

cttcaaatga attccctccg cgccgaggat actgccgtgt actattgtgc taaggatagt      360

cagctgcgaa gccttctata ctttgagtgg ttgagccagg ggtattttga ctactgggga      420

caggggacct tagtgaccgt tagcagcgct agtacaaagg gaccttctgt tttccctctt      480

gccccctcct ctaaatccac tagcggcggg acagctgctc taggatgcct tgtcaaggat      540

tactttcccg agcctgttac agtctcctgg aactccggcg ctcttacatc cggggtgcac      600

acttttcctg cggtcctcca aagctccggg ctttatagtt tgagtagcgt cgtgacagtg      660

ccttcgagtt ctctggggac acaaacatac atctgtaatg tcaaccacaa gcccagtaac      720

acaaaggttg acaagaaagt ggagccaaaa agttgtgaca agacacacac atgtcctccc      780

tgccctgccc ctgaattgct cggagggcca tccgtgtttc tttttccccc aaaacccaag      840

gatactctca tgatttcccg aacccctgag gtcacatgcg tggtcgtcga tgtcagccat      900

gaggaaccag acgtgaagtt caattggtac gtagatgggg tagaggtgca caatgccaaa      960

accaagcctc gggaggaaca gtataacagc acatacagag ttgtgtcagt gctcaccgtg     1020

ctgcaccagg attggctgaa tggcaaagag tataagtgca aagtctccaa caaggccctt     1080

cctgctccta tcgaaaagac aatatcaaag gccaagggcc agccacgaga gcctcaagtc     1140

tacactcttc ccccatcgag agatgaactt acgaaaaacc aggtttcact cacatgcctc     1200

gtgaaaggct tttacccttc tgatattgct gtggaatggg agtcaaatgg ccagcctgaa     1260

aacaactata agacaacgcc cccagtcctt gatagcgacg ggtccttttt cctgtattcg     1320

aagctgaccg tggataagtc aagatggcag cagggcaacg tgttctcatg ttccgtcatg     1380

cacgaggcgc ttcataatca ttatacacag aaaagcctga gtcttagccc tgggcgaaaa     1440

cgaagggctc ccgtgaaaca gacactgaat tttgatcttc ttaagcttgc cggggatgtc     1500

gaatcaaacc ctgggcctat gtatcggatg cagctacttc tacttattgc actttccctg     1560

gcattagtaa caaattcaga tatcgtgatg acacagtcgc ctgatagtct cgctgtgtct     1620

cttggggaga gggccaccat taactgcaag agctcacaga gtgtgctgta ctcaagcaac     1680

aacaagaact atcttgcttg gtatcagcag aagcctgggc agcctcccaa gctcctcata     1740

tactgggctt caacaagaga atccggtgta cctgatcgat tttctggctc ggggtcgggg     1800

acagatttca ccttaactat ctctagcctg caagctgagg acgtggctgt ctattactgt     1860

cagcagtact actccactcc gctcacgttt ggccagggga caaaagtgga aatcaagaga     1920

actgttgctg ctccatccgt ctttatattt ccgccttctg acgaacagct caagagtggt     1980

acagcatccg tggtttgcct gctgaacaac ttctacccac gcgaagctaa agtgcagtgg     2040

aaggttgata atgctctgca atcggggaat agccaggaaa gcgttacaga acaggattct     2100

aaggattcga catactccct ttcatctaca cttacattga gcaaggctga ctatgagaaa     2160

cacaaggtct acgcttgcga agtcacacat caggggcttt ctagccctgt cacaaagagc     2220

tttaacagag gagaatgt                                                   2238


<210>  19
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 35 cDNA

<400>  19
atgtatcgga tgcaactttt gtcctgcatt gccctatctc tcgccctggt taccaacagt       60

caggttcagc ttgttgaaag cggcggtggc gtcgtccaac ctggtcgctc attgcggctg      120

agctgcgccg cttccggctt tactttctca acttacgcca tgcattgggt tagacaagcc      180

cctggcaaag gcttggaatg ggttgccgtt attagctatg acgcgaacta caagtactat      240

gctgattccg taaaggggcg cttcactatt tcacgagaca actccaaaaa caccctatac      300

cttcaaatga actcattacg ggctgaggac accgcagttt actattgcgc aaaggactcg      360

cagctccgga gcctcctcta ttttgaatgg ctgtcccaag gatatttcga ctactggggc      420

cagggtacac tggttaccgt gtcatccgca agcaccaaag ggccctctgt atttcctctc      480

gctccgtcgt ccaagtcaac ctcaggcggc accgctgcac tgggctgcct ggtcaaggac      540

tatttccccg aacccgtgac cgtttcctgg aacagtggtg ctctgacatc tggggtccat      600

acctttcccg ccgtgctcca atcaagtgga ctgtatagcc tctcgagtgt tgtaaccgtg      660

ccttcttcat cgctcggtac ccaaacctac atttgtaacg tcaatcacaa gcccagcaac      720

accaaagtcg ataagaaggt tgaacctaag tcctgtgata agacgcacac gtgcccaccc      780

tgtcccgctc ccgaactgtt aggcggcccc tctgtgtttc tgtttccccc taaaccaaag      840

gacaccttga tgattagcag gacacccgag gttacctgtg tcgttgttga cgtgtcgcat      900

gaggaacccg acgtaaagtt caattggtat gtagacgggg ttgaagtgca caacgccaag      960

accaaacccc gggaggaaca gtacaacagt acctatcggg ttgttagcgt tttgacggtc     1020

ctgcatcaag actggctgaa cggaaaggag tacaaatgca aagtgtcgaa caaggccctg     1080

cccgcaccta tcgaaaagac catcagcaag gctaagggac agcctagaga gccccaagtt     1140

tataccttgc ccccgtcccg ggatgaacta accaagaatc aagtttcgct gacctgtcta     1200

gtcaaaggct tttacccctc cgacattgct gtggagtggg aaagcaatgg gcaacccgag     1260

aacaactata agactactcc acccgttctg gactctgacg gatccttttt cctgtactcg     1320

aaattgacag ttgacaagag ccggtggcag cagggcaacg tgttctcgtg ttccgttatg     1380

catgaggcac tacacaacca ctacacccag aagtcactgt cgcttagccc cggaaggaag     1440

aggagggccc ctgtgaagca aaccctgaac ttcgacctct tgaaattagc cggcgatgta     1500

gaatccaatc ccgggcccat gtataggatg caactgctgt tgctgattgc actgtcactg     1560

gcattagtta ctaattctga cattgttatg acccagtcgc cggactctct cgctgtctcg     1620

ctgggcgaaa gagccaccat taactgtaaa agctcgcagt cagtgctgta ctcctctaac     1680

aacaagaact atcttgcttg gtatcagcaa aaacccggcc agcccccaaa gctgctgata     1740

tactgggcca gcaccaggga aagcggcgtt cccgaccgtt ttagtggctc cggcagtggt     1800

accgacttta ccctgaccat ctcgtcactc caagccgaag atgtcgctgt gtactattgc     1860

cagcagtact attccacccc actgacgttt ggacaaggga ccaaagtgga gatcaagcgc     1920

acagtagccg cgccctcggt ctttatcttt cccccctcgg acgaacaact caagtctggc     1980

accgcttccg ttgtttgtct gttgaacaac ttctatcccc gggaagctaa ggttcagtgg     2040

aaggttgaca acgcgctgca aagcgggaac agtcaggaat cagtcaccga acaggactct     2100

aaggacagca cctatagcct gagcagcact ttgaccctgt cgaaggcgga ttacgaaaag     2160

cataaagtct atgcatgcga agtgacccac caagggctgt cctcccccgt gaccaaaagc     2220

ttcaataggg gcgaatgt                                                   2238


<210>  20
<211>  2238
<212>  DNA
<213>  Artifical sequence

<400>  20
atgtatcgaa tgcagctctt gtcatgtatc gctctctcac tcgctctcgt cacgaacagt       60

caggttcagt tagtggagag tggaggggga gtagtgcagc caggaagaag cttgagacta      120

tcttgcgccg cttccggttt cacattttcc acatatgcta tgcattgggt ccgccaggcc      180

cccggcaaag gccttgagtg ggtggcggtc ataagctatg acgccaacta caagtactat      240

gccgactcag ttaaaggccg gtttacaatt tctcgagata actcgaaaaa cacgctgtat      300

ttgcaaatga attcactcag ggccgaggat accgctgttt actattgcgc taaagattct      360

cagctaagaa gtctgctgta ttttgaatgg ctgtcacaag gatatttcga ttactgggga      420

cagggcacgc tggtcaccgt gtcatcagcc tcaacgaaag ggccatctgt tttccccctc      480

gctccctcat caaaatcaac ctcaggaggg accgccgccc ttggttgcct cgttaaggat      540

tactttcccg aacctgtcac ggtgtcatgg aacagtggtg cactgacgtc aggggtgcat      600

actttcccgg ctgtgctaca gtccagtggg ctgtactctc tgagctcagt cgtgacggtg      660

cccagctcat ccctgggcac acagacctat atctgcaacg tcaaccacaa accatcaaat      720

accaaggttg ataagaaggt tgagcccaaa tcgtgcgaca aaacacacac ctgtccccct      780

tgcccggccc ccgagctcct cggaggtcct tctgtgttct tatttccccc taaacccaag      840

gatactctga tgatatcacg cacacccgag gtcacatgcg ttgtagtgga tgtcagccat      900

gaggagcccg atgtgaaatt caattggtac gtcgacgggg tggaggttca taacgcaaag      960

accaaaccca gagaggagca gtataactca acatatcgag tcgtatcagt cttgactgtg     1020

cttcatcaag actggctgaa tggaaaggag tataagtgta aagtgtcaaa caaagctttg     1080

cctgctccca tcgagaaaac gatatcgaag gctaaagggc agccccgaga gccccaggtt     1140

tacaccctgc ctccctcccg tgacgagctg acaaagaatc aggtttcact gacgtgccta     1200

gtcaagggat tctatccatc cgacattgct gtagaatggg agagtaacgg ccagccggag     1260

aacaattaca aaaccacgcc acccgtgctg gactcagacg gttcattctt cctctactca     1320

aaactgacag tggacaaatc acggtggcag cagggcaatg tattctcctg ctccgttatg     1380

catgaggcac tccacaacca ctatacgcag aaatctctct cgctgtcacc cggccgtaaa     1440

agacgggctc ccgtgaaaca gactctgaat tttgaccttc ttaagctggc tggagatgtc     1500

gagtccaatc ccggacctat gtataggatg cagctcctct tattgattgc actgagtctg     1560

gctcttgtaa cgaatagcga tattgtcatg actcagagtc ccgattcact cgctgtatca     1620

cttggggaga gggccaccat caattgcaaa tcatcacagt cagtgttgta cagctctaac     1680

aacaaaaact acctggcttg gtaccagcag aaacccggac agccccctaa actcctcatc     1740

tactgggctt ctacccgcga atctggggtg cccgatagat tcagcggctc tgggagtggc     1800

accgatttca ccctgacgat aagcagtctc caggccgagg acgttgctgt gtactattgc     1860

cagcagtatt acagtacgcc cctgacattc ggacagggta ccaaagttga gatcaaacgg     1920

actgtggctg caccctctgt tttcattttt cctccctccg acgagcagct gaaaagtggt     1980

accgcatccg ttgtgtgcct tctcaacaac ttttatcccc gggaagcgaa agtacagtgg     2040

aaagttgata acgccctcca gtctgggaac tcgcaggaga gcgtaaccga acaggactca     2100

aaagattcaa catatagttt gtcatctacg cttaccctgt ctaaggctga ttacgagaaa     2160

cataaggtct atgcttgcga ggttacgcat caaggattgt caagccccgt gactaagagc     2220

ttcaataggg gagagtgt                                                   2238


<210>  21
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 cDNA

<400>  21
atgtaccgaa tgcagctcct gtcttgtatt gctttaagct tagcccttgt cactaattca       60

caagtgcagt tggtagagtc cggtggcggc gtggtacagc cggggcgctc ccttcgtctg      120

agctgtgctg catccggctt tacattttcc acttatgcca tgcattgggt cagacaggcc      180

cctgggaaag gtcttgaatg ggttgccgtg atatcttacg atgccaatta caagtactac      240

gccgactccg tcaaaggacg ctttacaatc agccgggaca acagcaagaa cacactgtat      300

ctgcaaatga attccctgcg cgcggaggac acagccgtct actattgcgc taaggattcc      360

cagttgagaa gtctgctata ctttgagtgg ctaagccagg ggtactttga ctactggggc      420

caggggacac tagtgacagt ctctagcgcg tccacgaagg gaccctctgt gtttcctctg      480

gccccaagct ccaagtcaac atccgggggg actgcagcct taggatgtct ggttaaagac      540

tacttccctg aacctgtgac cgtgtcctgg aacagcgggg cactgacaag cggcgtgcac      600

acatttccgg cggtgttaca gtctagcgga ctgtacagcc tctcgagcgt agttacagtg      660

cccagcagtt cccttgggac acaaacttac atttgcaatg tcaatcataa gccaagcaac      720

accaaagtcg ataagaaggt tgagcctaag agctgcgata agacccatac ttgtccgccc      780

tgccctgccc ctgagttgct gggggggccc agtgtttttc ttttccctcc aaaacccaag      840

gatacgctca tgatatcccg tactcctgaa gttacatgcg tagtagtgga cgtgtcccat      900

gaggaacccg acgtgaaatt caattggtac gtggacggag tcgaggttca caatgctaag      960

acaaaacctc gagaggagca gtacaatagc acataccgtg tggtatccgt gctgacagtg     1020

ctacaccagg attggctgaa cgggaaggag tataagtgta aagtctccaa taaggccctg     1080

ccagctccca ttgagaaaac catatccaag gccaagggcc agccccgaga gccccaggtc     1140

tatacactgc ccccatcccg ggacgagctg acaaagaatc aagtgtccct tacatgtctt     1200

gtaaaaggat tctatccctc ggatatagcc gtagagtggg aaagcaacgg ccagcccgag     1260

aacaattaca aaacaacacc ccctgtgctg gatagcgacg gcagcttttt tctgtactcc     1320

aaattgacag ttgacaaaag cagatggcag caggggaatg tgttcagttg ctccgtgatg     1380

catgaggcct tgcataatca ttacacacag aagtcactgt ccctgtcccc cgggcgcaaa     1440

agaagggccc ccgtaaaaca gaccttgaat tttgatttgc tcaaattagc cggcgatgtg     1500

gagagcaacc caggaccgat gtacaggatg cagctattgt tactcatcgc cctttctctg     1560

gcactcgtta ctaattccga catagtgatg actcagagcc ccgacagcct ggccgtatcc     1620

ctgggggaaa gggccaccat caattgcaaa tctagtcaga gcgtattgta ctcctccaac     1680

aacaagaact acctcgcatg gtatcagcag aagcctgggc agccccccaa actgctgata     1740

tactgggctt ccacaagaga gtccggggtt ccagaccgtt ttagcgggag tgggagcggg     1800

acagatttta cgctcaccat cagcagccta caggctgagg acgtggccgt gtactactgt     1860

cagcagtact actcgactcc actaacattt gggcagggca caaaagttga gataaaacgc     1920

acagtggctg cgccgagcgt gttcattttt ccaccctctg acgaacagct aaagagcggg     1980

accgcctccg tcgtgtgttt actcaacaat ttctaccccc gggaggctaa agtgcagtgg     2040

aaagtagaca acgcacttca gtctgggaac agtcaggaga gcgtgacaga gcaggactca     2100

aaggacagca catatagcct cagcagcacg ctgacactgt ccaaagccga ctacgagaaa     2160

cacaaagtgt acgcctgcga ggtcacacat cagggcttgt cctcccccgt tacaaaaagc     2220

tttaatcgtg gagagtgt                                                   2238


<210>  22
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 42 cDNA

<400>  22
atgtatagaa tgcagctcct ttcttgcatt gccctatcac tagcattagt cacgaattca       60

caagtgcagc ttgttgaatc aggaggcggc gttgtgcagc ctggccgttc acttcgcctg      120

agttgcgctg caagcggttt cacattttca acttacgcaa tgcattgggt cagacaggct      180

ccaggaaaag gtctagaatg ggtggctgtg atctcatacg acgctaacta taagtactac      240

gccgattcag tgaaaggcag attcacaatt tctcgtgata actcaaagaa taccctgtac      300

ctacagatga actcactgag ggcagaggat accgcagttt actactgtgc aaaagacagc      360

cagttacggt cgttgctgta cttcgagtgg ctgtcacaag gctacttcga ttattgggga      420

cagggcaccc tagttaccgt gtccagtgca agcaccaaag ggcccagcgt tttccctctc      480

gccccctcat caaaatcaac ctcagggggc actgcagcat tgggttgcct ggtcaaagat      540

tactttcctg agcctgtcac cgtttcctgg aattctggcg cactaactag tggcgtgcac      600

acatttccag cggtcttaca aagttcaggc ctctattcat tgtcatccgt cgttaccgtc      660

ccttcatcat ctctgggcac ccagacgtac atctgtaatg ttaaccacaa accttcgaac      720

acaaaagttg acaaaaaggt tgaacccaaa tcatgcgata agacacatac gtgtcccccg      780

tgccctgcac cggagctgct cggtggccca tcagtgtttc ttttcccacc caaaccaaaa      840

gatactctga tgatctcacg gacaccagaa gtgacctgtg ttgtggttga tgtcagccac      900

gaggaacccg atgttaagtt caattggtac gttgatggcg ttgaggttca caacgccaaa      960

acgaaaccca gagaggagca gtacaacagt acttaccgtg ttgtatcagt tttgactgta     1020

ctgcaccagg actggctgaa tggcaaagag tacaaatgca aagtttctaa taaggctctc     1080

cccgcgccca tcgaaaagac catctcaaaa gcaaaagggc agccccgcga acctcaagtt     1140

tacaccttgc ccccatcccg tgatgaactg acgaaaaatc aagtgtctct cacatgtttg     1200

gttaagggct tctacccgtc tgatatagcc gtcgaatggg aatccaacgg ccagcccgag     1260

aacaactata agacgacgcc acccgtactg gatagtgacg gcagcttttt cttatactca     1320

aaactgacag ttgacaaatc aagatggcag cagggcaacg tattttcttg ctctgtgatg     1380

cacgaggcac tccacaatca ctacactcag aaatcactat ctctgagccc tgggcgaaaa     1440

cgccgcgccc ccgtaaaaca gaccttgaac ttcgatctac tgaagctggc tggagatgta     1500

gagagtaatc ccggcccaat gtaccggatg cagttgttat tactgatagc actttccctg     1560

gcactggtta ccaacagcga tattgttatg actcagtccc ccgactctct ggctgtgtca     1620

ttaggggaaa gggcaaccat caattgtaaa agtagtcagt cagtgttgta ctcatcaaac     1680

aacaagaact acctcgcgtg gtaccaacag aaacctggcc agccccctaa actgcttatc     1740

tactgggcat cgacgcgaga gtcaggcgtt cccgatcgat tcagtggcag cggcagtggc     1800

acagatttta cacttacgat ttcatccctg caagccgagg acgtcgctgt ctattactgt     1860

cagcagtatt acagcacacc tctgacattc ggccagggca ctaaggttga aatcaaaagg     1920

accgtcgctg caccctcggt attcattttt ccaccctctg atgaacagct gaagtctggg     1980

accgcctcag ttgtctgtct gctcaacaat ttctacccgc gtgaagcaaa agttcagtgg     2040

aaagtggaca acgcacttca gtccgggaac tcacaggaat cggttacaga gcaggatagc     2100

aaagattcaa cctattcact ctcatctaca ctgaccctgt ctaaagcaga ttacgagaag     2160

cacaaggttt acgcatgcga agtgacacac cagggcctgt cctcccccgt tactaagagc     2220

ttcaaccgcg gcgaatgt                                                   2238


<210>  23
<211>  2238
<212>  DNA
<213>  Artificial sequence

<220>
<223>  F16 B42

<400>  23
atgtaccgga tgcagctttt atcttgtatt gcactttctc tcgctcttgt tacgaatagt       60

caggtccagc tcgtggagag tggagggggc gtcgtgcagc ccggaagatc tctacggcta      120

tcctgcgccg ctagtggttt cacgttttct acgtatgcga tgcactgggt cagacaggct      180

ccgggcaaag gtcttgaatg ggttgctgtc atctcttatg acgctaatta caagtactac      240

gccgattctg tgaaaggtcg ctttaccata tctagggaca acagcaagaa taccctttac      300

cttcaaatga attccttacg cgctgaagat actgccgtct actactgcgc taaggatagc      360

cagctgcgtt ctttactgta ctttgaatgg ctgagtcagg gttactttga ctactgggga      420

caggggaccc tagtgacagt gtctagcgcc tctacaaagg gtcccagtgt ctttcccctt      480

gctccctctt caaaatctac ctccggcggt accgctgctc ttggatgcct cgtgaaggac      540

tatttcccgg aacctgtgac tgtgtcttgg aatagtggcg cactcacatc gggggtacac      600

acatttccgg ctgtccttca atcatctggg ctgtatagcc tgagttccgt ggtcactgtg      660

cccagtagct cccttggaac ccagacatac atttgcaacg tcaatcataa gccttctaac      720

acgaaagtag ataagaaagt tgaaccaaag tcttgcgata agacccatac gtgtccccca      780

tgtccggccc ctgaacttct tggcggcccc tctgtctttc ttttcccacc aaagccaaaa      840

gatacgctca tgattagtcg caccccggaa gttacctgtg tggtggtcga cgtgtcacat      900

gaggagccag atgttaagtt taattggtat gtcgacggcg tggaagtcca taatgctaaa      960

accaagcccc gcgaggaaca gtataatagc acatacaggg tagtgtctgt gctcaccgtg     1020

ctgcatcagg actggctgaa tggaaaagaa tacaagtgta aagtgtcaaa taaggcactt     1080

ccggctccga tagagaaaac aattagcaag gccaagggtc aaccgcgaga accacaagtt     1140

tacacactgc ccccgtcacg cgacgaactc acgaagaatc aggtttcctt gacttgcctg     1200

gtcaagggat tttacccgag tgacatcgcg gtagaatggg agagtaatgg acagcctgag     1260

aacaattaca agaccactcc gcccgttctg gactccgacg gctcattttt cttgtactcc     1320

aaactgacgg tcgacaaaag tcggtggcag caggggaatg tgttttcctg ctctgtgatg     1380

catgaagcac ttcacaatca ctatacccag aaaagtctta gccttagtcc cgggaggaag     1440

cgcagagctc ccgtaaagca gacccttaac tttgatcttc taaaacttgc tggcgatgtg     1500

gagtccaatc ctggtccgat gtaccgcatg caacttctcc tcctgatcgc cctgagtcta     1560

gctctcgtca caaattctga catcgtgatg actcagtctc cggactctct tgctgtctca     1620

ctcggagaga gggctactat caattgcaag agcagtcaga gtgtgctgta ttcatctaac     1680

aataagaact atcttgcttg gtaccagcag aagcctgggc aacccccaaa gttactgatc     1740

tactgggcca gcacacgcga atcgggcgtc ccggaccggt ttagtggtag tggatctggc     1800

acagatttta ccctgaccat aagttccctg caagccgaag atgtggctgt ttactattgc     1860

cagcagtact acagtacccc attgacgttc ggccagggga ctaaggtcga aatcaagcgc     1920

acggtggcag ctccttctgt gtttatcttc ccaccgagtg acgagcagct caagagcggt     1980

actgctagtg tcgtgtgctt gcttaacaat ttttatcccc gcgaggctaa ggtccagtgg     2040

aaagttgaca acgcccttca gtccggcaat agtcaggaat ctgtgaccga acaggactct     2100

aaggacagca cttattctct ttcctcaaca ctcacactca gcaaggccga ctatgaaaaa     2160

cataaggttt acgcatgcga agtgacacat cagggtcttt cttctcccgt cacaaagagc     2220

ttcaaccgcg gcgaatgt                                                   2238


<210>  24
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  25
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutated IL2

<400>  25

Met Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu Val 
1               5                   10                  15      


Thr Asn Ser 
            


