                         SEQUENCE LISTING

<110>  Bowles, Robert
       Setton, Lori
       Guilak, Farshid
       Gersbach, Charles
       Brunger, Jonathan
       Farhang, Niloofar
       Stover, Joshua
 
<120>  RNA-Guided Transcritptional Regulation and Methods of Using the 
       Same for the Treatment of Back Pain

<130>  21101.0331P1

<150>  62/230,931
<151>  2015-06-18

<160>  90    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  1
cagtgttgca acagcgggac                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  2
agactcgggc atagagatca                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  3
gaatggcagg cacccagtca                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  4
ataagcgtcc gacacatgat                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  5
gcaaggggct tattgcccct                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  6
ggagtcgcca actcaattcg                                                   20


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  7
tggggtcctt gggcgactgc                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  8
agaggcattt cccggactcg                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  9
agcacaaagt tggctgcgcc                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  10
gggaggtgac acccagttta                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  11
aaagtagcct gacgtatccg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  12
tttttaatac aaggtaatct                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  13
gaaggctgga tgcgtgttta                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  14
tcaagtgatc ttcccgcctc                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  15
gtgagggtga ggcactaatt                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  16
cgggctttcg ctttcagtcg                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  17
aggtatcggc ccagcgatgc                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  18
catgtcctaa aatcacgaac                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  19
aattgtgata ctagcggtta                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  20
aggataaaac tagggcccat                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  21
caaggtttta cgctcccatt                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  22
gggaggtgac acccagttta                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  23
taaacacctg acacacggtc                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  24
cggaagactc accaccgtaa                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  25
agggcgtatc agccaccagt                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  26
cggctttcgt aaccgcaccc                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  27
agagccgggc tcctgcggat                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  28
aggctcgttt acgtaagtct                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  29
ggaataacgg ggtcatgaac                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  30
cagtggccgc ctgtcgacga                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  31
cgcacgaacc ccttggcgcc                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  32
tcaacaggat cacgacctta                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  33
atcgtggttc atcgccaaac                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  34
gctgcatctc tatgcggaca                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  35
ttagcgtctc agaaaacgcg                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  36
aaactgtgca tagaatagcg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  37
aagatcaacg tagggcgtcg                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  38
ccttgctccg ggtgcgaccg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  39
gcgcccgggc ggagcacgat                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  40
aattagctgg gcgcaatggc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  41
gagtaggggt tggcgtcgag                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  42
gacgctagtt ttgacgtcgc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  43
gagtcgctgt ggacgccctt                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  44
tgaaggcggt tgctactcga                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide RNA

<400>  45
aaggcagctg cttgcatcgc                                                   20


<210>  46
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46
gaaggcugga ugcguguuua                                                   20


<210>  47
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47
ucaagugauc uucccgccuc                                                   20


<210>  48
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synethic construct

<400>  48
gugaggguga ggcacuaauu                                                   20


<210>  49
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  49
cgggcuuucg cuuucagucg                                                   20


<210>  50
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  50
agguaucggc ccagcgaugc                                                   20


<210>  51
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  51
cauguccuaa aaucacgaac                                                   20


<210>  52
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  52
aauugugaua cuagcgguua                                                   20


<210>  53
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  53
aggauaaaac uagggcccau                                                   20


<210>  54
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54
caagguuuua cgcucccauu                                                   20


<210>  55
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55
gggaggugac acccaguuua                                                   20


<210>  56
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56
uaaacaccug acacacgguc                                                   20


<210>  57
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57
cggaagacuc accaccguaa                                                   20


<210>  58
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58
agggcguauc agccaccagu                                                   20


<210>  59
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59
cggcuuucgu aaccgcaccc                                                   20


<210>  60
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60
agagccgggc uccugcggau                                                   20


<210>  61
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61
aggcucguuu acguaagucu                                                   20


<210>  62
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62
ggaauaacgg ggucaugaac                                                   20


<210>  63
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  63
caguggccgc cugucgacga                                                   20


<210>  64
<211>  20
<212>  RNA
<213>  Synthetic construct

<400>  64
cgcacgaacc ccuuggcgcc                                                   20


<210>  65
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65
ucaacaggau cacgaccuua                                                   20


<210>  66
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66
aucgugguuc aucgccaaac                                                   20


<210>  67
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67
gcugcaucuc uaugcggaca                                                   20


<210>  68
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68
uuagcgucuc agaaaacgcg                                                   20


<210>  69
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  69
aaacugugca uagaauagcg                                                   20


<210>  70
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  70
aagaucaacg uagggcgucg                                                   20


<210>  71
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71
ccuugcuccg ggugcgaccg                                                   20


<210>  72
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  72
gcgcccgggc ggagcacgau                                                   20


<210>  73
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  73
aauuagcugg gcgcaauggc                                                   20


<210>  74
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  74
gaguaggggu uggcgucgag                                                   20


<210>  75
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  75
gacgcuaguu uugacgucgc                                                   20


<210>  76
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  76
gagucgcugu ggacgcccuu                                                   20


<210>  77
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  77
ugaaggcggu ugcuacucga                                                   20


<210>  78
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  78
aaggcagcug cuugcaucgc                                                   20


<210>  79
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  79
caguguugca acagcgggac                                                   20


<210>  80
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  80
agacucgggc auagagauca                                                   20


<210>  81
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  81
gaauggcagg cacccaguca                                                   20


<210>  82
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  82
auaagcgucc gacacaugau                                                   20


<210>  83
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  83
gcaaggggcu uauugccccu                                                   20


<210>  84
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  84
ggagucgcca acucaauucg                                                   20


<210>  85
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  85
ugggguccuu gggcgacugc                                                   20


<210>  86
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  86
agaggcauuu cccggacucg                                                   20


<210>  87
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  87
agcacaaagu uggcugcgcc                                                   20


<210>  88
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  88
gggaggugac acccaguuua                                                   20


<210>  89
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  89
aaaguagccu gacguauccg                                                   20


<210>  90
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  90
uuuuuaauac aagguaaucu                                                   20


