               SEQUENCE LISTING

<110> UCBL
      INSERM
      INRA
      BERGEN TEKNOLOGIOVERFORING

<120> Novel use of FGF19 

<130> S4 PCT

<150> EP15305990
<151> 2015-06-25

<160> 10

<170> BiSSAP 1.3

<210> 1
<211> 216
<212> PRT
<213> Homo sapiens

<400> 1
Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      
Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          
His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              
Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  
Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  
Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      
Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         
Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             
Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 
Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 
Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     
Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         
Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             
Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     

<210> 2
<211> 220
<212> PRT
<213> Sus scrofa

<400> 2
Ala Met Arg Ser Ala Pro Ser Arg Cys Ala Val Val Arg Ala Leu Val 
1               5                   10                  15      
Leu Ala Gly Leu Trp Leu Ala Ala Ala Gly Arg Pro Leu Ala Phe Ser 
            20                  25                  30          
Asp Ala Gly Pro His Val His Tyr Gly Trp Gly Glu Ser Val Arg Leu 
        35                  40                  45              
Arg His Leu Tyr Thr Ala Ser Pro His Gly Val Ser Ser Cys Phe Leu 
    50                  55                  60                  
Arg Ile His Ser Asp Gly Pro Val Asp Cys Ala Pro Gly Gln Ser Ala 
65                  70                  75                  80  
His Ser Leu Met Glu Ile Arg Ala Val Ala Leu Ser Thr Val Ala Ile 
                85                  90                  95      
Lys Gly Glu Arg Ser Gly Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys 
            100                 105                 110         
Met Gln Gly Gln Thr Gln Tyr Ser Asp Glu Asp Cys Ala Phe Glu Glu 
        115                 120                 125             
Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Trp Ser Lys Lys His His 
    130                 135                 140                 
Leu Pro Val Ser Leu Ser Ser Ala Arg Gln Arg Gln Leu Tyr Lys Gly 
145                 150                 155                 160 
Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Ser Thr Leu 
                165                 170                 175     
Pro Ala Glu Pro Glu Asp Leu Gln Asp Pro Phe Lys Ser Asp Leu Phe 
            180                 185                 190         
Ser Leu Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Arg Ile Ala Ala 
        195                 200                 205             
Lys Leu Gly Ala Val Lys Ser Pro Ser Phe Tyr Lys 
    210                 215                 220 

<210> 3
<211> 218
<212> PRT
<213> bos taurus

<400> 3
Met Arg Ser Ala Pro Ser Arg Cys Ala Val Ala Arg Ala Leu Val Leu 
1               5                   10                  15      
Ala Gly Leu Trp Leu Ala Ala Ala Gly Arg Pro Leu Ala Phe Ser Asp 
            20                  25                  30          
Ala Gly Pro His Val His Tyr Gly Trp Gly Glu Ser Val Arg Leu Arg 
        35                  40                  45              
His Leu Tyr Thr Ala Gly Pro Gln Gly Leu Tyr Ser Cys Phe Leu Arg 
    50                  55                  60                  
Ile His Ser Asp Gly Ala Val Asp Cys Ala Gln Val Gln Ser Ala His 
65                  70                  75                  80  
Ser Leu Met Glu Ile Arg Ala Val Ala Leu Ser Thr Val Ala Ile Lys 
                85                  90                  95      
Gly Glu Arg Ser Val Leu Tyr Leu Cys Met Asp Ala Asp Gly Lys Met 
            100                 105                 110         
Gln Gly Leu Thr Gln Tyr Ser Ala Glu Asp Cys Ala Phe Glu Glu Glu 
        115                 120                 125             
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Trp Ser Arg Lys His His Leu 
    130                 135                 140                 
Pro Val Ser Leu Ser Ser Ser Arg Gln Arg Gln Leu Phe Lys Ser Arg 
145                 150                 155                 160 
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Ser Thr Ile Pro 
                165                 170                 175     
Ala Glu Pro Glu Asp Leu Gln Glu Pro Leu Lys Pro Asp Phe Phe Leu 
            180                 185                 190         
Pro Leu Lys Thr Asp Ser Met Asp Pro Phe Gly Leu Ala Thr Lys Leu 
        195                 200                 205             
Gly Ser Val Lys Ser Pro Ser Phe Tyr Asn 
    210                 215             

<210> 4
<211> 94
<212> PRT
<213> Equus caballus

<400> 4
Ala Ala Gly Arg Pro Leu Ala Leu Ser Asp Ala Gly Pro His Val His 
1               5                   10                  15      
Tyr Gly Trp Gly Glu Pro Ile Arg Leu Arg His Leu Tyr Thr Ala Gly 
            20                  25                  30          
Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Ala 
        35                  40                  45              
Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Val Glu Ile Arg 
    50                  55                  60                  
Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His Ser Val Arg 
65                  70                  75                  80  
Tyr Leu Cys Met Gly Ala Asp Gly Arg Met Gln Gly Leu Val 
                85                  90                  

<210> 5
<211> 137
<212> PRT
<213> Ovis aries

<400> 5
Leu Met Glu Ile Arg Ala Val Ala Leu Ser Thr Val Ala Ile Lys Gly 
1               5                   10                  15      
Glu Arg Ser Val Leu Phe Leu Cys Met Asp Ala Asp Gly Lys Met Gln 
            20                  25                  30          
Gly Leu Thr Gln Tyr Ser Ala Glu Asp Cys Ala Phe Glu Glu Glu Ile 
        35                  40                  45              
Arg Pro Asp Gly Tyr Asn Val Tyr Trp Ser Arg Lys His His Leu Pro 
    50                  55                  60                  
Val Ser Leu Ser Ser Ser Arg Gln Arg Gln Leu Phe Lys Ser Arg Gly 
65                  70                  75                  80  
Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Ser Thr Ile Pro Ala 
                85                  90                  95      
Glu Pro Glu Asp Leu Gln Glu Pro Leu Lys Pro Asp Phe Phe Leu Pro 
            100                 105                 110         
Leu Lys Thr Asp Ser Met Asp Pro Phe Gly Leu Ala Thr Lys Leu Gly 
        115                 120                 125             
Ser Val Lys Ser Pro Ser Phe Tyr Thr 
    130                 135         

<210> 6
<211> 193
<212> PRT
<213> canis familiairis

<400> 6
Pro Leu Ala Phe Ser Asp Ala Gly Pro His Val His Ser Phe Trp Gly 
1               5                   10                  15      
Glu Pro Ile Arg Leu Arg His Leu Tyr Thr Ala Gly Pro His Gly Leu 
            20                  25                  30          
Ser Ser Cys Phe Leu Arg Ile Arg Ala Asp Gly Gly Val Asp Cys Ala 
        35                  40                  45              
Arg Gly Gln Ser Ala His Ser Leu Met Glu Met Arg Ala Val Ala Leu 
    50                  55                  60                  
Arg Thr Val Ala Ile Lys Gly Val His Ser Gly Arg Tyr Leu Cys Met 
65                  70                  75                  80  
Gly Ala Asp Gly Arg Met Gln Gly Leu Pro Gln Tyr Ser Ala Gly Asp 
                85                  90                  95      
Cys Thr Phe Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Trp 
            100                 105                 110         
Ser Lys Lys His His Leu Pro Ile Ser Leu Ser Ser Ala Lys Gln Arg 
        115                 120                 125             
Gln Leu Tyr Lys Gly Arg Gly Phe Leu Pro Leu Ser His Phe Leu Pro 
    130                 135                 140                 
Ile Leu Pro Gly Ser Pro Thr Glu Pro Arg Asp Leu Glu Asp His Val 
145                 150                 155                 160 
Glu Ser Asp Gly Phe Ser Ala Ser Leu Glu Thr Asp Ser Met Asp Pro 
                165                 170                 175     
Phe Gly Ile Ala Thr Lys Ile Gly Leu Val Lys Ser Pro Ser Phe Gln 
            180                 185                 190         
Lys 
    

<210> 7
<211> 219
<212> PRT
<213> Felis catus

<400> 7
Met Arg Ser Ala Pro Ser Gln Cys Ala Val Thr Arg Ala Leu Val Leu 
1               5                   10                  15      
Ala Gly Leu Trp Leu Ala Ala Ala Gly Arg Pro Leu Ala Phe Ser Asp 
            20                  25                  30          
Ala Gly Pro His Val His Tyr Gly Trp Gly Glu Pro Ile Arg Leu Arg 
        35                  40                  45              
His Leu Tyr Thr Ala Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg 
    50                  55                  60                  
Ile Arg Ala Asp Gly Gly Val Asp Cys Ala Arg Ser Gln Ser Ala His 
65                  70                  75                  80  
Ser Leu Val Glu Ile Arg Ala Val Ala Leu Arg Thr Val Ala Ile Lys 
                85                  90                  95      
Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Arg Met 
            100                 105                 110         
Gln Gly Leu Leu Gln Tyr Ser Ala Gly Asp Cys Ala Phe Gln Glu Glu 
        115                 120                 125             
Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu 
    130                 135                 140                 
Pro Val Ser Leu Ser Ser Ala Ile Gln Arg Gln Leu Tyr Lys Gly Arg 
145                 150                 155                 160 
Gly Phe Leu Pro Leu Ser His Phe Leu Pro Met Leu Pro Gly Ser Pro 
                165                 170                 175     
Ala Glu Pro Arg Asp Leu Gln Asp His Val Glu Ser Glu Arg Phe Ser 
            180                 185                 190         
Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Ile Ala Thr Lys 
        195                 200                 205             
Met Gly Leu Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215                 

<210> 8
<211> 218
<212> PRT
<213> Oryctolagus cuniculus

<400> 8
Met Arg Arg Ala Pro Ser Gly Gly Ala Ala Ala Arg Ala Leu Val Leu 
1               5                   10                  15      
Ala Gly Leu Trp Leu Ala Ala Ala Ala Arg Pro Leu Ala Leu Ser Asp 
            20                  25                  30          
Ala Gly Pro His Leu His Tyr Gly Trp Gly Glu Pro Val Arg Leu Arg 
        35                  40                  45              
His Leu Tyr Ala Thr Ser Ala His Gly Val Ser His Cys Phe Leu Arg 
    50                  55                  60                  
Ile Arg Ala Asp Gly Ala Val Asp Cys Glu Arg Ser Gln Ser Ala His 
65                  70                  75                  80  
Ser Leu Leu Glu Ile Arg Ala Val Ala Leu Arg Thr Val Ala Phe Lys 
                85                  90                  95      
Gly Val His Ser Ser Arg Tyr Leu Cys Met Gly Ala Asp Gly Arg Met 
            100                 105                 110         
Arg Gly Gln Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Gln Glu Glu 
        115                 120                 125             
Ile Ser Ser Gly Tyr Asn Val Tyr Arg Ser Thr Thr His His Leu Pro 
    130                 135                 140                 
Val Ser Leu Ser Ser Ala Lys Gln Arg His Leu Tyr Lys Thr Arg Gly 
145                 150                 155                 160 
Phe Leu Pro Leu Ser His Phe Leu Pro Val Leu Pro Leu Ala Ser Glu 
                165                 170                 175     
Glu Thr Ala Ala Leu Gly Asp His Pro Glu Ala Asp Leu Phe Ser Pro 
            180                 185                 190         
Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Met Ala Thr Lys Leu 
        195                 200                 205             
Gly Pro Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215             

<210> 9
<211> 218
<212> PRT
<213> Rattus norvegicus

<400> 9
Met Ala Arg Lys Trp Ser Gly Arg Ile Val Ala Arg Ala Leu Val Leu 
1               5                   10                  15      
Ala Thr Leu Trp Leu Ala Val Ser Gly Arg Pro Leu Val Gln Gln Ser 
            20                  25                  30          
Gln Ser Val Ser Asp Glu Gly Pro Leu Phe Leu Tyr Gly Trp Gly Lys 
        35                  40                  45              
Ile Thr Arg Leu Gln Tyr Leu Tyr Ser Ala Gly Pro Tyr Val Ser Asn 
    50                  55                  60                  
Cys Phe Leu Arg Ile Arg Ser Asp Gly Ser Val Asp Cys Glu Glu Asp 
65                  70                  75                  80  
Gln Asn Glu Arg Asn Leu Leu Glu Phe Arg Ala Val Ala Leu Lys Thr 
                85                  90                  95      
Ile Ala Ile Lys Asp Val Ser Ser Val Arg Tyr Leu Cys Met Ser Ala 
            100                 105                 110         
Asp Gly Lys Ile Tyr Gly Leu Ile Arg Tyr Ser Glu Glu Asp Cys Thr 
        115                 120                 125             
Phe Arg Glu Glu Met Asp Cys Leu Gly Tyr Asn Gln Tyr Arg Ser Met 
    130                 135                 140                 
Lys His His Leu His Ile Ile Phe Ile Lys Ala Lys Pro Arg Glu Gln 
145                 150                 155                 160 
Leu Gln Gly Gln Lys Pro Ser Asn Phe Ile Pro Ile Phe His Arg Ser 
                165                 170                 175     
Phe Phe Glu Ser Thr Asp Gln Leu Arg Ser Lys Met Phe Ser Leu Pro 
            180                 185                 190         
Leu Glu Ser Asp Ser Met Asp Pro Phe Arg Met Val Glu Asp Val Asp 
        195                 200                 205             
His Leu Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215             

<210> 10
<211> 218
<212> PRT
<213> Mus musculus

<400> 10
Met Ala Arg Lys Trp Asn Gly Arg Ala Val Ala Arg Ala Leu Val Leu 
1               5                   10                  15      
Ala Thr Leu Trp Leu Ala Val Ser Gly Arg Pro Leu Ala Gln Gln Ser 
            20                  25                  30          
Gln Ser Val Ser Asp Glu Asp Pro Leu Phe Leu Tyr Gly Trp Gly Lys 
        35                  40                  45              
Ile Thr Arg Leu Gln Tyr Leu Tyr Ser Ala Gly Pro Tyr Val Ser Asn 
    50                  55                  60                  
Cys Phe Leu Arg Ile Arg Ser Asp Gly Ser Val Asp Cys Glu Glu Asp 
65                  70                  75                  80  
Gln Asn Glu Arg Asn Leu Leu Glu Phe Arg Ala Val Ala Leu Lys Thr 
                85                  90                  95      
Ile Ala Ile Lys Asp Val Ser Ser Val Arg Tyr Leu Cys Met Ser Ala 
            100                 105                 110         
Asp Gly Lys Ile Tyr Gly Leu Ile Arg Tyr Ser Glu Glu Asp Cys Thr 
        115                 120                 125             
Phe Arg Glu Glu Met Asp Cys Leu Gly Tyr Asn Gln Tyr Arg Ser Met 
    130                 135                 140                 
Lys His His Leu His Ile Ile Phe Ile Gln Ala Lys Pro Arg Glu Gln 
145                 150                 155                 160 
Leu Gln Asp Gln Lys Pro Ser Asn Phe Ile Pro Val Phe His Arg Ser 
                165                 170                 175     
Phe Phe Glu Thr Gly Asp Gln Leu Arg Ser Lys Met Phe Ser Leu Pro 
            180                 185                 190         
Leu Glu Ser Asp Ser Met Asp Pro Phe Arg Met Val Glu Asp Val Asp 
        195                 200                 205             
His Leu Val Lys Ser Pro Ser Phe Gln Lys 
    210                 215             

