                         SEQUENCE LISTING

<110>  Regents of the University of Texas System
 
<120>  Methods and compositions for the treatment of symptoms associated
        with intercranial hemorrage

<130>  2105-11101

<140>  62184049
<141>  2015-06-24

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2837
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DERIVED FROM HUMAN SEQUENCES

<400>  1
aattgccgcc accatgaagc tggtgtttct cgtgctgctg tttctgggag ccctgggact       60

ctgtctcgct ggtagacgcc gacggagtgt gcagtggtgt gctgtgtccc agcccgaggc      120

aacaaagtgc ttccagtggc agagaaatat gcggaaagtg cgcggccccc ctgtcagttg      180

cattaagcgc gactcaccta tccagtgtat tcaggccatc gctgaaaacc gagcagacgc      240

cgtgactctg gatggcggct tcatctacga ggcaggtctc gccccttata agctgagacc      300

agtggccgct gaagtctacg gcaccgagcg acagccaagg acacactact atgctgtggc      360

agtggtcaag aaagggggta gtttccagct gaatgagctc cagggcctga agtcatgcca      420

taccgggctg aggagaacag ccggttggaa tgtgcccatt ggcactctcc ggccttttct      480

gaactggacc ggaccaccag aacctatcga ggcagcagtg gcacgcttct tttccgcttc      540

ttgtgtccct ggggccgaca aaggccagtt cccaaatctc tgccggctgt gtgcagggac      600

tggtgaaaac aagtgcgcct ttagctccca ggagccatac ttcagttatt caggcgcctt      660

taaatgtctg agagacggcg ctggagatgt ggcattcatt cgggaatcaa ccgtctttga      720

ggacctgagc gatgaagccg agcgcgacga atacgagctg ctctgcccag ataacacacg      780

aaagcccgtg gacaagttca aagattgtca cctggctcgg gtgccttccc atgctgtggt      840

cgcacgctct gtcaatggga aagaagatgc tatctggaac ctgctcagac aggcacagga      900

gaagtttggc aaggacaaaa gccccaaatt ccagctgttt ggcagccctt ccggacagaa      960

ggacctgctc ttcaaagatt ccgccattgg attttctaga gtgcctccac ggatcgatag     1020

cgggctgtac ctcgggtccg gttatttcac agctattcag aatctgagga agagcgagga     1080

agaggtggct gcacgacgag caagagtggt ctggtgcgct gtcggggaac aggagctccg     1140

gaaatgtaac cagtggtcag ggctgagcga gggttccgtg acttgctcta gtgccagcac     1200

cacagaagac tgtatcgctc tggtgctcaa gggagaggca gacgctatga gcctggatgg     1260

cggatacgtg tataccgcag gcaaatgcgg actcgtgcct gtcctggccg aaaattacaa     1320

gtctcagcag tcaagcgacc ccgatcctaa ctgtgtggat cggccagtcg agggatatct     1380

cgcagtggcc gtggtccgaa ggtctgacac aagtctgact tggaactctg tgaaggggaa     1440

gaaaagttgc cacactgcag tcgaccgcac cgccggatgg aatattccca tggggctgct     1500

cttcaaccag accggatcct gcaagttcga cgagtacttt tctcagagtt gtgctccagg     1560

gtcagatccc aggagcaatc tctgcgcact gtgtatcggc gacgaacagg gagagaacaa     1620

gtgcgtgcct aattctaacg aacgatacta tgggtataca ggtgccttca ggtgtctggc     1680

cgagaatgct ggtgacgtgg cttttgtcaa ggatgtgaca gtcctgcaga acactgatgg     1740

aaacaataac gaggcttggg caaaggacct gaaactcgca gatttcgccc tgctctgcct     1800

ggacggaaag aggaaaccag tgaccgaagc cagatcttgt cacctggcca tggctcccaa     1860

ccatgctgtg gtcagtcgca tggataaggt ggagcgactg aaacaggtcc tgctccacca     1920

gcaggccaag ttcggcagga atggaagcga ctgccctgat aagttctgtc tgtttcagtc     1980

cgaaacaaaa aacctgctct ttaatgacaa cactgagtgt ctcgccagac tgcatggcaa     2040

gactacctac gagaaatatc tgggtcccca gtacgtggct ggcatcacaa acctgaagaa     2100

gtgctctacc tcacctctcc tggaagcctg cgagttcctg cgaaaaggat ccgagcgcaa     2160

atgttgcgtg gagtgccctc cctgtcccgc tcctcccgtg gccggaccct cagtcttcct     2220

cttcccaccc aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt     2280

ggtggtggac gtgagccacg aagaccctga ggtccagttc aactggtacg tggacggcgt     2340

ggaggtgcat aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgttccgtgt     2400

ggtcagcgtc ctcaccgtcg tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa     2460

ggtctccaac aaaggcctcc cagctcccat cgagaaaacc atctccaaaa ccaaagggca     2520

gcctcgagaa ccacaggtgt acaccctgcc tccctctcgg gaggagatga ccaagaacca     2580

ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga     2640

gagcaatggg cagccggaga acaactacaa gaccacgcct cccatgctgg actccgacgg     2700

ctccttcttc ctctatagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt     2760

cttctcatgc tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc     2820

cctgtctccg ggtaaat                                                    2837


<210>  2
<211>  941
<212>  PRT
<213>  Artificial sequence

<220>
<223>  DERIVED FROM HUMAN SEQUENCES

<400>  2

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala Gly Arg Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser 
            20                  25                  30          


Gln Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys 
        35                  40                  45              


Val Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln 
    50                  55                  60                  


Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp 
65                  70                  75                  80  


Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro 
                85                  90                  95      


Val Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr 
            100                 105                 110         


Tyr Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu 
        115                 120                 125             


Leu Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly 
    130                 135                 140                 


Trp Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly 
145                 150                 155                 160 


Pro Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser 
                165                 170                 175     


Cys Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu 
            180                 185                 190         


Cys Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro 
        195                 200                 205             


Tyr Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly 
    210                 215                 220                 


Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp 
225                 230                 235                 240 


Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg 
                245                 250                 255     


Lys Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser 
            260                 265                 270         


His Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp 
        275                 280                 285             


Asn Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro 
    290                 295                 300                 


Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe 
305                 310                 315                 320 


Lys Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser 
                325                 330                 335     


Gly Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg 
            340                 345                 350         


Lys Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys 
        355                 360                 365             


Ala Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu 
    370                 375                 380                 


Ser Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys 
385                 390                 395                 400 


Ile Ala Leu Val Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly 
                405                 410                 415     


Gly Tyr Val Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala 
            420                 425                 430         


Glu Asn Tyr Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val 
        435                 440                 445             


Asp Arg Pro Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser 
    450                 455                 460                 


Asp Thr Ser Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His 
465                 470                 475                 480 


Thr Ala Val Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu 
                485                 490                 495     


Phe Asn Gln Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser 
            500                 505                 510         


Cys Ala Pro Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile 
        515                 520                 525             


Gly Asp Glu Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg 
    530                 535                 540                 


Tyr Tyr Gly Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly 
545                 550                 555                 560 


Asp Val Ala Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly 
                565                 570                 575     


Asn Asn Asn Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala 
            580                 585                 590         


Leu Leu Cys Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser 
        595                 600                 605             


Cys His Leu Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp 
    610                 615                 620                 


Lys Val Glu Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe 
625                 630                 635                 640 


Gly Arg Asn Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser 
                645                 650                 655     


Glu Thr Lys Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg 
            660                 665                 670         


Leu His Gly Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val 
        675                 680                 685             


Ala Gly Ile Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu 
    690                 695                 700                 


Ala Cys Glu Phe Leu Arg Lys Gly Ser Glu Arg Lys Cys Cys Val Glu 
705                 710                 715                 720 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
                725                 730                 735     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            740                 745                 750         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        755                 760                 765             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    770                 775                 780                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
785                 790                 795                 800 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                805                 810                 815     


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            820                 825                 830         


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        835                 840                 845             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    850                 855                 860                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
865                 870                 875                 880 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                885                 890                 895     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            900                 905                 910         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        915                 920                 925             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    930                 935                 940     


<210>  3
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Core hinge sequence derived from Human IgG1

<400>  3

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  4
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Core hinge sequence derived from Human IgG2

<400>  4

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  5
<211>  61
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Core hinge sequence derived from Human IgG3

<400>  5

Glu Leu Lys Thr Pro Leu Asp Thr Thr His Thr Cys Pro Arg Cys Pro 
1               5                   10                  15      


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
            20                  25                  30          


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro 
        35                  40                  45              


Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60      


<210>  6
<211>  12
<212>  PRT
<213>  Artifical sequence

<220>
<223>  Core hinge sequence derived from Human IgG4

<400>  6

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


